Julie Sneddon, PhD

Title(s)Associate Professor, Cell and Tissue Biology
SchoolSchool of Dentistry
Phone415-502-3380
PronounsShe/Her/Hers
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    Collapse Biography 
    Collapse education and training
    Harvard University, Cambridge, MAA.B.Biochemical Sciences
    Stanford University, Stanford, CAPh.D.Genomics & Biochemistry
    Harvard University, Cambridge, MAPostdoctoral FellowshipDiabetes & Stem Cells
    Collapse awards and honors
    Program for Breakthrough Biomedical Research2017New Frontier Research Award
    Zentrum Munchen2019Helmholtz Young Investigator in Diabetes Award
    American Pancreatic Association2019Young Investigator Travel Award
    Program for Breakthrough Biomedical Research2021New Frontier Research Award

    Collapse Overview 
    Collapse overview
    The primary focus of Dr. Sneddon’s research is the niche in pancreatic development and Type I Diabetes. Her research group employs the tools of stem cell biology, developmental biology, genomics, and tissue engineering. Dr. Sneddon’s laboratory studies the underlying biology of the cellular microenvironment, including the cellular diversity and lineage relationships of the non-epithelial compartment of the pancreas in the context of organogenesis, adult organ function, and disease. The hope is that a deeper understanding of the identity and biology of non-epithelial “niche” cell types within the pancreas will enable a more directed and efficient attempt at replacing lost cell and organ function via regenerative medicine.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Replenishable prevascularized cell encapsulation devices increase graft survival and function in the subcutaneous space. Bioeng Transl Med. 2023 Jul; 8(4):e10520. Chendke GS, Kharbikar BN, Ashe S, Faleo G, Sneddon JB, Tang Q, Hebrok M, Desai TA. PMID: 37476069; PMCID: PMC10354771.
      View in: PubMed   Mentions: 4  
    2. Single-cell chromatin accessibility of developing murine pancreas identifies cell state-specific gene regulatory programs. Mol Metab. 2023 07; 73:101735. de la O S, Yao X, Chang S, Liu Z, Sneddon JB. PMID: 37178817; PMCID: PMC10230264.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    3. Rab11 is essential to pancreas morphogenesis, lumen formation and endocrine mass. Dev Biol. 2023 07; 499:59-74. Barlow HR, Ahuja N, Bierschenk T, Htike Y, Fassetta L, Azizoglu DB, Flores J, Gao N, De la O S, Sneddon JB, Marciano DK, Cleaver O. PMID: 37172642.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    4. Loss of Fgf9 in mice leads to pancreatic hypoplasia and asplenia. iScience. 2023 Apr 21; 26(4):106500. Patzek S, Liu Z, de la O S, Chang S, Byrnes LE, Zhang X, Ornitz DM, Sneddon JB. PMID: 37096042; PMCID: PMC10121468.
      View in: PubMed   Mentions: 3  
    5. Doxycycline Significantly Enhances Induction of Induced Pluripotent Stem Cells to Endoderm by Enhancing Survival Through Protein Kinase B Phosphorylation. Hepatology. 2021 10; 74(4):2102-2117. Peaslee C, Esteva-Font C, Su T, Munoz-Howell A, Duwaerts CC, Liu Z, Rao S, Liu K, Medina M, Sneddon JB, Maher JJ, Mattis AN. PMID: 33982322; PMCID: PMC8544023.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    6. Human pluripotent stem cell-derived insulin-producing cells: A regenerative medicine perspective. Cell Metab. 2021 04 06; 33(4):721-731. Migliorini A, Nostro MC, Sneddon JB. PMID: 33826915; PMCID: PMC8117263.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    7. Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla. Nat Commun. 2021 02 17; 12(1):1096. Bautista JL, Cramer NT, Miller CN, Chavez J, Berrios DI, Byrnes LE, Germino J, Ntranos V, Sneddon JB, Burt TD, Gardner JM, Ye CJ, Anderson MS, Parent AV. PMID: 33597545; PMCID: PMC7889611.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    8. A Hierarchy of Proliferative and Migratory Keratinocytes Maintains the Tympanic Membrane. Cell Stem Cell. 2021 02 04; 28(2):315-330.e5. Frumm SM, Yu SK, Chang J, Artichoker JA, Scaria SM, Lee KP, Byrnes LE, Sneddon JB, Tward AD. PMID: 33181078; PMCID: PMC8962966.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    9. A single-cell atlas and lineage analysis of the adult Drosophila ovary. Nat Commun. 2020 11 06; 11(1):5628. Rust K, Byrnes LE, Yu KS, Park JS, Sneddon JB, Tward AD, Nystul TG. PMID: 33159074; PMCID: PMC7648648.
      View in: PubMed   Mentions: 58     Fields:    Translation:Animals
    10. Beta Living through Alpha Cells. Cell Stem Cell. 2019 04 04; 24(4):503-505. Patzek S, Sneddon JB. PMID: 30951656.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    11. Pancreatic development: one cell at a (pseudo)time. EMBO J. 2019 Apr 15; 38(8). Liu Z, Sneddon JB. PMID: 30914428; PMCID: PMC6463208.
      View in: PubMed   Mentions:    Fields:    
    12. Lineage dynamics of murine pancreatic development at single-cell resolution. Nat Commun. 2018 09 25; 9(1):3922. Byrnes LE, Wong DM, Subramaniam M, Meyer NP, Gilchrist CL, Knox SM, Tward AD, Ye CJ, Sneddon JB. PMID: 30254276; PMCID: PMC6156586.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
    13. Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype. J Clin Invest. 2018 10 01; 128(10):4343-4358. Wang C, de Mochel NSR, Christenson SA, Cassandras M, Moon R, Brumwell AN, Byrnes LE, Li A, Yokosaki Y, Shan P, Sneddon JB, Jablons D, Lee PJ, Matthay MA, Chapman HA, Peng T. PMID: 29999500; PMCID: PMC6159975.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    14. Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges. Cell Stem Cell. 2018 Jun 01; 22(6):810-823. Sneddon JB, Tang Q, Stock P, Bluestone JA, Roy S, Desai T, Hebrok M. PMID: 29859172; PMCID: PMC6007036.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansAnimalsCells
    15. Defining epithelial cell dynamics and lineage relationships in the developing lacrimal gland. Development. 2017 07 01; 144(13):2517-2528. Farmer DT, Nathan S, Finley JK, Shengyang Yu K, Emmerson E, Byrnes LE, Sneddon JB, McManus MT, Tward AD, Knox SM. PMID: 28576768; PMCID: PMC5536870.
      View in: PubMed   Mentions: 30     Fields:    
    16. Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes. Cell. 2017 02 23; 168(5):775-788.e12. Cheng CW, Villani V, Buono R, Wei M, Kumar S, Yilmaz OH, Cohen P, Sneddon JB, Perin L, Longo VD. PMID: 28235195; PMCID: PMC5357144.
      View in: PubMed   Mentions: 165     Fields:    Translation:HumansAnimalsCells
    17. Brief report: VGLL4 is a novel regulator of survival in human embryonic stem cells. Stem Cells. 2013 Dec; 31(12):2833-41. Tajonar A, Maehr R, Hu G, Sneddon JB, Rivera-Feliciano J, Cohen DE, Elledge SJ, Melton DA. PMID: 23765749; PMCID: PMC4617635.
      View in: PubMed   Mentions: 12     Fields:    
    18. Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme. Nature. 2012 Nov 29; 491(7426):765-8. Sneddon JB, Borowiak M, Melton DA. PMID: 23041930; PMCID: PMC6005657.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    19. The contribution of niche-derived factors to the regulation of cancer cells. Methods Mol Biol. 2009; 568:217-32. Sneddon JB. PMID: 19582430.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    20. Location, location, location: the cancer stem cell niche. Cell Stem Cell. 2007 Dec 13; 1(6):607-11. Sneddon JB, Werb Z. PMID: 18371402; PMCID: PMC2571117.
      View in: PubMed   Mentions: 64     Fields:    
    21. The macrophage-stimulating protein pathway promotes metastasis in a mouse model for breast cancer and predicts poor prognosis in humans. Proc Natl Acad Sci U S A. 2007 May 01; 104(18):7570-5. Welm AL, Sneddon JB, Taylor C, Nuyten DS, van de Vijver MJ, Hasegawa BH, Bishop JM. PMID: 17456594; PMCID: PMC1855278.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    22. When should one subtract background fluorescence in 2-color microarrays? Biostatistics. 2007 Oct; 8(4):695-707. Scharpf RB, Iacobuzio-Donahue CA, Sneddon JB, Parmigiani G. PMID: 17164465.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    23. Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation. Proc Natl Acad Sci U S A. 2006 Oct 03; 103(40):14842-7. Sneddon JB, Zhen HH, Montgomery K, van de Rijn M, Tward AD, West R, Gladstone H, Chang HY, Morganroth GS, Oro AE, Brown PO. PMID: 17003113; PMCID: PMC1578503.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansCells
    24. Predicting a local recurrence after breast-conserving therapy by gene expression profiling. Breast Cancer Res. 2006; 8(5):R62. Nuyten DS, Kreike B, Hart AA, Chi JT, Sneddon JB, Wessels LF, Peterse HJ, Bartelink H, Brown PO, Chang HY, van de Vijver MJ. PMID: 17069664; PMCID: PMC1779489.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    25. Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival. Proc Natl Acad Sci U S A. 2005 Mar 08; 102(10):3738-43. Chang HY, Nuyten DS, Sneddon JB, Hastie T, Tibshirani R, Sørlie T, Dai H, He YD, van't Veer LJ, Bartelink H, van de Rijn M, Brown PO, van de Vijver MJ. PMID: 15701700; PMCID: PMC548329.
      View in: PubMed   Mentions: 304     Fields:    Translation:Humans
    26. Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds. PLoS Biol. 2004 Feb; 2(2):E7. Chang HY, Sneddon JB, Alizadeh AA, Sood R, West RB, Montgomery K, Chi JT, van de Rijn M, Botstein D, Brown PO. PMID: 14737219; PMCID: PMC314300.
      View in: PubMed   Mentions: 368     Fields:    Translation:HumansCells
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