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Julie Sneddon, PhD

Title(s)Assistant Professor, Cell and Tissue Biology
SchoolSchool of Dentistry
Address35 Medical Center Way
San Francisco CA 94143
Phone415-502-3380
ORCID ORCID Icon0000-0002-7404-8598 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Harvard University, Cambridge, MAA.B.Biochemical Sciences
    Stanford University, Stanford, CAPh.D.Genomics & Biochemistry
    Harvard University, Cambridge, MAPostdoctoral FellowshipDiabetes & Stem Cells

    Collapse Overview 
    Collapse Overview
    The primary focus of Dr. Sneddon’s research is the niche in pancreatic development and Type I Diabetes. Her research group employs the tools of stem cell biology, developmental biology, genomics, and tissue engineering. Dr. Sneddon’s laboratory studies the underlying biology of the cellular microenvironment, including the cellular diversity and lineage relationships of the non-epithelial compartment of the pancreas in the context of organogenesis, adult organ function, and disease. The hope is that a deeper understanding of the identity and biology of non-epithelial “niche” cell types within the pancreas will enable a more directed and efficient attempt at replacing lost cell and organ function via regenerative medicine.

    Collapse Research 
    Collapse Research Activities and Funding
    A novel progenitor population in pancreatic endocrine cell development
    NIH/NIDDK R01DK118421Apr 1, 2019 - Mar 31, 2024
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Beta Living through Alpha Cells. Cell Stem Cell. 2019 04 04; 24(4):503-505. Patzek S, Sneddon JB. PMID: 30951656.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Pancreatic development: one cell at a (pseudo)time. EMBO J. 2019 Apr 15; 38(8). Liu Z, Sneddon JB. PMID: 30914428.
      View in: PubMed   Mentions:    Fields:    
    3. Lineage dynamics of murine pancreatic development at single-cell resolution. Nat Commun. 2018 09 25; 9(1):3922. Byrnes LE, Wong DM, Subramaniam M, Meyer NP, Gilchrist CL, Knox SM, Tward AD, Ye CJ, Sneddon JB. PMID: 30254276.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    4. Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype. J Clin Invest. 2018 10 01; 128(10):4343-4358. Wang C, de Mochel NSR, Christenson SA, Cassandras M, Moon R, Brumwell AN, Byrnes LE, Li A, Yokosaki Y, Shan P, Sneddon JB, Jablons D, Lee PJ, Matthay MA, Chapman HA, Peng T. PMID: 29999500.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    5. Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges. Cell Stem Cell. 2018 Jun 01; 22(6):810-823. Sneddon JB, Tang Q, Stock P, Bluestone JA, Roy S, Desai T, Hebrok M. PMID: 29859172.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    6. Defining epithelial cell dynamics and lineage relationships in the developing lacrimal gland. Development. 2017 07 01; 144(13):2517-2528. Farmer DT, Nathan S, Finley JK, Shengyang Yu K, Emmerson E, Byrnes LE, Sneddon JB, McManus MT, Tward AD, Knox SM. PMID: 28576768.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    7. Fasting-Mimicking Diet Promotes Ngn3-Driven ß-Cell Regeneration to Reverse Diabetes. Cell. 2017 02 23; 168(5):775-788.e12. Cheng CW, Villani V, Buono R, Wei M, Kumar S, Yilmaz OH, Cohen P, Sneddon JB, Perin L, Longo VD. PMID: 28235195.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    8. Brief report: VGLL4 is a novel regulator of survival in human embryonic stem cells. Stem Cells. 2013 Dec; 31(12):2833-41. Tajonar A, Maehr R, Hu G, Sneddon JB, Rivera-Feliciano J, Cohen DE, Elledge SJ, Melton DA. PMID: 23765749.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    9. Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme. Nature. 2012 Nov 29; 491(7426):765-8. Sneddon JB, Borowiak M, Melton DA. PMID: 23041930.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    10. The contribution of niche-derived factors to the regulation of cancer cells. Methods Mol Biol. 2009; 568:217-32. Sneddon JB. PMID: 19582430.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    11. Location, location, location: the cancer stem cell niche. Cell Stem Cell. 2007 Dec 13; 1(6):607-11. Sneddon JB, Werb Z. PMID: 18371402.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    12. The macrophage-stimulating protein pathway promotes metastasis in a mouse model for breast cancer and predicts poor prognosis in humans. Proc Natl Acad Sci U S A. 2007 May 01; 104(18):7570-5. Welm AL, Sneddon JB, Taylor C, Nuyten DS, van de Vijver MJ, Hasegawa BH, Bishop JM. PMID: 17456594.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    13. When should one subtract background fluorescence in 2-color microarrays? Biostatistics. 2007 Oct; 8(4):695-707. Scharpf RB, Iacobuzio-Donahue CA, Sneddon JB, Parmigiani G. PMID: 17164465.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    14. Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation. Proc Natl Acad Sci U S A. 2006 Oct 03; 103(40):14842-7. Sneddon JB, Zhen HH, Montgomery K, van de Rijn M, Tward AD, West R, Gladstone H, Chang HY, Morganroth GS, Oro AE, Brown PO. PMID: 17003113.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
    15. Predicting a local recurrence after breast-conserving therapy by gene expression profiling. Breast Cancer Res. 2006; 8(5):R62. Nuyten DS, Kreike B, Hart AA, Chi JT, Sneddon JB, Wessels LF, Peterse HJ, Bartelink H, Brown PO, Chang HY, van de Vijver MJ. PMID: 17069664.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    16. Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival. Proc Natl Acad Sci U S A. 2005 Mar 08; 102(10):3738-43. Chang HY, Nuyten DS, Sneddon JB, Hastie T, Tibshirani R, Sørlie T, Dai H, He YD, van't Veer LJ, Bartelink H, van de Rijn M, Brown PO, van de Vijver MJ. PMID: 15701700.
      View in: PubMed   Mentions: 332     Fields:    Translation:Humans
    17. Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds. PLoS Biol. 2004 Feb; 2(2):E7. Chang HY, Sneddon JB, Alizadeh AA, Sood R, West RB, Montgomery K, Chi JT, van de Rijn M, Botstein D, Brown PO. PMID: 14737219.
      View in: PubMed   Mentions: 346     Fields:    Translation:HumansCells
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