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Anthony Shum, MD

TitleAssociate Professor
SchoolUCSF School of Medicine
DepartmentMedicine
Address513 Parnassus Ave
San Francisco CA 94143
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    Collapse Biography 
    Collapse Education and Training
    University of ChicagoM.D.2000Pritzker School of Medicine
    Collapse Awards and Honors
    Arthritis Foundation2015Lee Howley Sr. Prize for Arthritis Scientific Research
    Rheumatology Research Foundation2015Innovative Research Grant
    UCSF2015Robert L. Kroc Chair in Rheumatic and Connective Tissue Diseases II
    American Society for Clinical Investigation2014Young Physician-Scientist Award
    American Thoracic Society2007American Thoracic Society Career Development Award
    Will Rogers Institute2005Will Rogers Institute Fellowship

    Collapse Overview 
    Collapse Overview
    I run a laboratory-based basic-translational research program that lies at the intersection of autoimmunity and pulmonary disease. My work is focused on the study of clinical disorders such as rheumatoid arthritis that have important disease manifestations in the lung. The goal of my research program to understand the basic mechanisms that control how the lung functions both as an important immune target in autoimmune disorders and as a critical factor in precipitating or propagating autoimmune inflammation.

    My lab enrolls patients into our research program to perform next generation sequencing studies that are designed to uncover novel insights into the molecular pathogenesis of disease. We have developed a whole exome sequencing (WES) analysis pipeline to identify rare genetic variants that cosegregate with disease in Mendelian disorders of autoimmunity. Much of our work involves the study of immune mechanisms in animal models or cellular and molecular investigations that are designed to functionally validate candidate mutations discovered in our sequencing pipeline.


    Collapse Research 
    Collapse Research Activities and Funding
    Translational studies of autoimmune-mediated lung disease
    NIH/NHLBI R01HL122533Dec 1, 2014 - Nov 30, 2019
    Role: Principal Investigator
    Mechanisms and Antigen Identification in a Novel Model of Autoimmune Lung Disease
    NIH/NHLBI K08HL095659Jul 1, 2009 - Jun 30, 2014
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Chung SA, Shum A. Rare variants, autoimmune disease, and arthritis. Curr Opin Rheumatol. 2016 Jul; 28(4):346-51. PMID: 27224741.
      View in: PubMed
    2. Shum A. T cell types that take your breath away. Sci Transl Med. 2015 Aug 19; 7(301):301fs33. PMID: 26290409.
      View in: PubMed
    3. Assayag D, Kim EJ, Elicker BM, Jones KD, Golden JA, King TE, Koth LL, Shum A, Wolters PJ, Collard HR, Lee JS. Survival in interstitial pneumonia with features of autoimmune disease: A comparison of proposed criteria. Respir Med. 2015 Oct; 109(10):1326-31. PMID: 26303338.
      View in: PubMed
    4. Assayag D, Vittinghoff E, Ryerson CJ, Cocconcelli E, Tonelli R, Hu X, Elicker BM, Golden JA, Jones KD, King TE, Koth LL, Lee JS, Ley B, Shum A, Wolters PJ, Ryu JH, Collard HR. The effect of bronchodilators on forced vital capacity measurement in patients with idiopathic pulmonary fibrosis. Respir Med. 2015 Aug; 109(8):1058-62. PMID: 26140806; PMCID: PMC4522344 [Available on 08/01/16].
    5. Landegren N, Sharon D, Shum A, Khan IS, Fasano KJ, Hallgren Å, Kampf C, Freyhult E, Ardesjö-Lundgren B, Alimohammadi M, Rathsman S, Ludvigsson JF, Lundh D, Motrich R, Rivero V, Fong L, Giwercman A, Gustafsson J, Perheentupa J, Husebye ES, Anderson MS, Snyder M, Kämpe O. Transglutaminase 4 as a prostate autoantigen in male subfertility. Sci Transl Med. 2015 Jun 17; 7(292):292ra101. PMID: 26084804.
      View in: PubMed
    6. Watkin LB, Jessen B, Wiszniewski W, Vece TJ, Jan M, Sha Y, Thamsen M, Santos-Cortez RL, Lee K, Gambin T, Forbes LR, Law CS, Stray-Pedersen A, Cheng MH, Mace EM, Anderson MS, Liu D, Tang LF, Nicholas SK, Nahmod K, Makedonas G, Canter DL, Kwok PY, Hicks J, Jones KD, Penney S, Jhangiani SN, Rosenblum MD, Dell SD, Waterfield MR, Papa FR, Muzny DM, Zaitlen N, Leal SM, Gonzaga-Jauregui C, Boerwinkle E, Eissa NT, Gibbs RA, Lupski JR, Orange JS, Shum A. COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis. Nat Genet. 2015 Jun; 47(6):654-60. PMID: 25894502; PMCID: PMC4513663 [Available on 12/01/15].
    7. Price JV, Haddon DJ, Kemmer D, Delepine G, Mandelbaum G, Jarrell JA, Gupta R, Balboni I, Chakravarty EF, Sokolove J, Shum A, Anderson MS, Cheng MH, Robinson WH, Browne SK, Holland SM, Baechler EC, Utz PJ. Protein microarray analysis reveals BAFF-binding autoantibodies in systemic lupus erythematosus. J Clin Invest. 2013 Dec; 123(12):5135-45. PMID: 24270423; PMCID: PMC3859403.
    8. Shum A, Alimohammadi M, Tan CL, Cheng MH, Metzger TC, Law CS, Lwin W, Perheentupa J, Bour-Jordan H, Carel JC, Husebye ES, De Luca F, Janson C, Sargur R, Dubois N, Kajosaari M, Wolters PJ, Chapman HA, Kämpe O, Anderson MS. BPIFB1 is a lung-specific autoantigen associated with interstitial lung disease. Sci Transl Med. 2013 Oct 9; 5(206):206ra139. PMID: 24107778; PMCID: PMC3882146.
    9. Lee JS, Kim EJ, Lynch KL, Elicker B, Ryerson CJ, Katsumoto TR, Shum A, Wolters PJ, Cerri S, Richeldi L, Jones KD, King TE, Collard HR. Prevalence and clinical significance of circulating autoantibodies in idiopathic pulmonary fibrosis. Respir Med. 2013 Feb; 107(2):249-55. PMID: 23186614; PMCID: PMC3543473.
    10. Su MA, Davini D, Cheng P, Giang K, Fan U, DeVoss JJ, Johannes KP, Taylor L, Shum A, Valenzise M, Meloni A, Bour-Jordan H, Anderson MS. Defective autoimmune regulator-dependent central tolerance to myelin protein zero is linked to autoimmune peripheral neuropathy. J Immunol. 2012 May 15; 188(10):4906-12. PMID: 22490868; PMCID: PMC3579634.
    11. Shum A, DeVoss J, Tan CL, Hou Y, Johannes K, O'Gorman CS, Jones KD, Sochett EB, Fong L, Anderson MS. Identification of an autoantigen demonstrates a link between interstitial lung disease and a defect in central tolerance. Sci Transl Med. 2009 Dec 2; 1(9):9ra20. PMID: 20368189; PMCID: PMC2856693.
    12. Devoss JJ, Shum A, Johannes KP, Lu W, Krawisz AK, Wang P, Yang T, Leclair NP, Austin C, Strauss EC, Anderson MS. Effector mechanisms of the autoimmune syndrome in the murine model of autoimmune polyglandular syndrome type 1. J Immunol. 2008 Sep 15; 181(6):4072-9. PMID: 18768863; PMCID: PMC2556863.
    13. Zhang L, Barker JM, Babu S, Su M, Stenerson M, Cheng M, Shum A, Zamir E, Badolato R, Law A, Eisenbarth GS, Anderson MS. A robust immunoassay for anti-interferon autoantibodies that is highly specific for patients with autoimmune polyglandular syndrome type 1. Clin Immunol. 2007 Nov; 125(2):131-7. PMID: 17825626; PMCID: PMC2080870.
    14. Cheng MH, Shum A, Anderson MS. What's new in the Aire? Trends Immunol. 2007 Jul; 28(7):321-7. PMID: 17556019.
      View in: PubMed
    15. Davis JL, Shum A, Huang L. A 36-year-old man with AIDS and relapsing, nonproductive cough. Chest. 2007 Jun; 131(6):1929-31. PMID: 17565026.
      View in: PubMed
    16. Sperling AI, Decker DC, DiPaolo RJ, Stern DA, Shum A, Bluestone JA. Selective expansion of Vgamma2-Vdelta7 TCR gammadelta cells in C57BL/6 mice is postnatal and extrathymic. J Immunol. 1997 Jul 1; 159(1):86-91. PMID: 9200442.
      View in: PubMed
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