Anthony Shum, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address555 Mission Bay Blvd South, #252H
San Francisco CA 94158
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    Collapse Biography 
    Collapse Education and Training
    University of ChicagoM.D.Pritzker School of Medicine
    University of California, San Francisco, CA2018Diversity, Equity, and Inclusion Champion Training
    Collapse Awards and Honors
    American Society for Clinical Investigation2022Elected Member
    Arthritis Foundation2015Lee Howley Sr. Prize for Arthritis Scientific Research
    Rheumatology Research Foundation2015Innovative Research Grant
    UCSF2015Robert L. Kroc Chair in Rheumatic and Connective Tissue Diseases II
    American Society for Clinical Investigation2014Young Physician-Scientist Award
    American Thoracic Society2007American Thoracic Society Career Development Award
    Will Rogers Institute2005Will Rogers Institute Fellowship

    Collapse Overview 
    Collapse Overview
    I run a laboratory-based basic-translational research program that lies at the intersection of autoimmunity and pulmonary disease. My work is focused on the study of clinical disorders such as rheumatoid arthritis that have important disease manifestations in the lung. The goal of my research program to understand the basic mechanisms that control how the lung functions both as an important immune target in autoimmune disorders and as a critical factor in precipitating or propagating autoimmune inflammation.

    My lab enrolls patients into our research program to perform next generation sequencing studies that are designed to uncover novel insights into the molecular pathogenesis of disease. We have developed a whole exome sequencing (WES) analysis pipeline to identify rare genetic variants that cosegregate with disease in Mendelian disorders of autoimmunity. Much of our work involves the study of immune mechanisms in animal models or cellular and molecular investigations that are designed to functionally validate candidate mutations discovered in our sequencing pipeline.

    Do you have a patient you think might have the COPA syndrome? We are enrolling COPA syndrome patients and other families with autoimmune/lung disease for our studies. Please contact: anthony.shum@ucsf.edu

    Collapse Research 
    Collapse Research Activities and Funding
    Unraveling the molecular mechanisms of impaired central tolerance in COPA syndrome
    NIH 1R01AI168299Mar 1, 2022 - Feb 28, 2027
    Role: Principal Investigator
    Defining the molecular mechanisms of COPA syndrome through computational modeling and functional studies
    NIH R21AI160107Apr 8, 2021 - Mar 31, 2023
    Role: Principal Investigator
    Defining the Role of Thymic Tolerance in the Pathogenesis of the COPA syndrome
    NIH R01AI137249Jan 16, 2018 - Dec 31, 2022
    Role: Principal Investigator
    Translational studies of autoimmune-mediated lung disease
    NIH R01HL122533Dec 1, 2014 - Nov 30, 2019
    Role: Principal Investigator
    Mechanisms and Antigen Identification in a Novel Model of Autoimmune Lung Disease
    NIH K08HL095659Jul 1, 2009 - Jun 30, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Twenty-year-old patient with polyarthritis since childhood showing cysts and ground glass attenuation on HRCT. Thorax. 2024 Mar 15; 79(4):384-385. Fagundes MDC, Bianco T, Nunes DP, Ostroski TKD, Bridi GDP, Kawassaki AM, Barbas CSV, Mendonça LO, Barros SF, Kalil J, Shum AK, Escuissato DL. PMID: 38195643.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Activated STING in the thymus alters T cell development and selection leading to autoimmunity. bioRxiv. 2024 Feb 19. Deng Z, Law CS, Kurra S, Simchoni N, Shum AK. PMID: 38464209; PMCID: PMC10925148.
      View in: PubMed   Mentions:
    3. Pathogenic COPA mutations decrease binding of dilysine motifs through allosteric effects. Biophysical Journal. 2024 Feb 1; 123(3):65a. Pavlova PA, Mandal MS, Simchoni SN, Law LC, Acharya AA, Shum SA, Gumbart GJ. .
      View in: Publisher Site   Mentions:
    4. COPA Syndrome from Diagnosis to Treatment: A Clinician's Guide. Rheum Dis Clin North Am. 2023 11; 49(4):789-804. Simchoni N, Vogel TP, Shum AK. PMID: 37821196; PMCID: PMC10866555.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. Antigenic responses are hallmarks of fibrotic interstitial lung diseases independent of underlying etiologies. medRxiv. 2023 May 11. Yoon YM, Velez TE, Upadhyay V, Vazquez SE, Lee CT, Selvan KC, Law CS, Blaine KM, Hollinger MK, Decker DC, Clark MR, Strek ME, Guzy RD, Adegunsoye A, Noth I, Wolters PJ, Anderson M, DeRisi JL, Shum AK, Sperling AI. PMID: 37214861; PMCID: PMC10197719.
      View in: PubMed   Mentions:
    6. PhIP-Seq uncovers novel autoantibodies and unique endotypes in interstitial lung disease. bioRxiv. 2023 Apr 24. Upadhyay V, Yoon YM, Vazquez SE, Velez TE, Jones KD, Lee CT, Law CS, Wolters PJ, Lee S, Yang MM, Farrand E, Noth I, Strek ME, Anderson M, DeRisi J, Sperling AI, Shum AK. PMID: 37163026; PMCID: PMC10168232.
      View in: PubMed   Mentions:
    7. Interstitial lung disease patients exhibit augmented germinal center responses in lung lymph nodes and increased serum reactivities to novel autoantigens. The Journal of Immunology. 2022 May 1; 208(1_Supplement):48.01-48.01. Yoon YY, Velez VT, Upadhyay UV, Vazquez VS, Lee LC, Blaine BK, Decker DD, Guzy GR, Adegunsoye AA, Strek SM, Noth NI, Anderson AM, DeRisi DJ, Shum SA, Sperling SA. .
      View in: Publisher Site   Mentions:
    8. COPA Syndrome (Ala239Pro) Presenting with Isolated Follicular Bronchiolitis in Early Childhood: Case Report. J Clin Immunol. 2021 10; 41(7):1660-1663. Psarianos P, Kwan JYY, Dell S, Wee WB, Rey-McIntyre K, Chen H, Dissanayake D, Laxer RM, Shum A, Liu FF, Yip KW. PMID: 34115278.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    9. Homeostatic regulation of STING by retrograde membrane traffic to the ER. The FASEB Journal. 2021 May 14; 35(S1). Mukai MK, Shum SA, Taguchi TT. .
      View in: Publisher Site   Mentions:
    10. Homeostatic regulation of STING by retrograde membrane traffic to the ER. Nat Commun. 2021 01 04; 12(1):61. Mukai K, Ogawa E, Uematsu R, Kuchitsu Y, Kiku F, Uemura T, Waguri S, Suzuki T, Dohmae N, Arai H, Shum AK, Taguchi T. PMID: 33397928; PMCID: PMC7782846.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    11. A defect in COPI-mediated transport of STING causes immune dysregulation in COPA syndrome. J Exp Med. 2020 11 02; 217(11). Deng Z, Chong Z, Law CS, Mukai K, Ho FO, Martinu T, Backes BJ, Eckalbar WL, Taguchi T, Shum AK. PMID: 32725126; PMCID: PMC7596814.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    12. A Defect in Thymic Tolerance Causes T Cell-Mediated Autoimmunity in a Murine Model of COPA Syndrome. J Immunol. 2020 05 01; 204(9):2360-2373. Deng Z, Law CS, Ho FO, Wang KM, Jones KD, Shin JS, Shum AK. PMID: 32198142; PMCID: PMC7324259.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    13. Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease. Nature. 2020 01; 577(7788):103-108. Lalaoui N, Boyden SE, Oda H, Wood GM, Stone DL, Chau D, Liu L, Stoffels M, Kratina T, Lawlor KE, Zaal KJM, Hoffmann PM, Etemadi N, Shield-Artin K, Biben C, Tsai WL, Blake MD, Kuehn HS, Yang D, Anderton H, Silke N, Wachsmuth L, Zheng L, Moura NS, Beck DB, Gutierrez-Cruz G, Ombrello AK, Pinto-Patarroyo GP, Kueh AJ, Herold MJ, Hall C, Wang H, Chae JJ, Dmitrieva NI, McKenzie M, Light A, Barham BK, Jones A, Romeo TM, Zhou Q, Aksentijevich I, Mullikin JC, Gross AJ, Shum AK, Hawkins ED, Masters SL, Lenardo MJ, Boehm M, Rosenzweig SD, Pasparakis M, Voss AK, Gadina M, Kastner DL, Silke J. PMID: 31827281; PMCID: PMC6930849.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansAnimals
    14. Analysis of pulmonary features and treatment approaches in the COPA syndrome. ERJ Open Res. 2018 Apr; 4(2). Tsui JL, Estrada OA, Deng Z, Wang KM, Law CS, Elicker BM, Jones KD, Dell SD, Gudmundsson G, Hansdottir S, Helfgott SM, Volpi S, Gattorno M, Waterfield MR, Chan AY, Chung SA, Ley B, Shum AK. PMID: 29977900; PMCID: PMC6019741.
      View in: PubMed   Mentions: 27  
    15. Type I interferon pathway activation in COPA syndrome. Clin Immunol. 2018 02; 187:33-36. Volpi S, Tsui J, Mariani M, Pastorino C, Caorsi R, Sacco O, Ravelli A, Shum AK, Gattorno M, Picco P. PMID: 29030294.
      View in: PubMed   Mentions: 44     Fields:    Translation:Humans
    16. Rare variants, autoimmune disease, and arthritis. Curr Opin Rheumatol. 2016 Jul; 28(4):346-51. Chung SA, Shum AK. PMID: 27224741; PMCID: PMC4910637.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    17. T cell types that take your breath away. Sci Transl Med. 2015 Aug 19; 7(301):301fs33. Shum AK. PMID: 26290409.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    18. Survival in interstitial pneumonia with features of autoimmune disease: a comparison of proposed criteria. Respir Med. 2015 Oct; 109(10):1326-31. Assayag D, Kim EJ, Elicker BM, Jones KD, Golden JA, King TE, Koth LL, Shum AK, Wolters PJ, Collard HR, Lee JS. PMID: 26303338.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    19. The effect of bronchodilators on forced vital capacity measurement in patients with idiopathic pulmonary fibrosis. Respir Med. 2015 Aug; 109(8):1058-62. Assayag D, Vittinghoff E, Ryerson CJ, Cocconcelli E, Tonelli R, Hu X, Elicker BM, Golden JA, Jones KD, King TE, Koth LL, Lee JS, Ley B, Shum AK, Wolters PJ, Ryu JH, Collard HR. PMID: 26140806; PMCID: PMC4522344.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    20. Transglutaminase 4 as a prostate autoantigen in male subfertility. Sci Transl Med. 2015 Jun 17; 7(292):292ra101. Landegren N, Sharon D, Shum AK, Khan IS, Fasano KJ, Hallgren Å, Kampf C, Freyhult E, Ardesjö-Lundgren B, Alimohammadi M, Rathsman S, Ludvigsson JF, Lundh D, Motrich R, Rivero V, Fong L, Giwercman A, Gustafsson J, Perheentupa J, Husebye ES, Anderson MS, Snyder M, Kämpe O. PMID: 26084804.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    21. COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis. Nat Genet. 2015 Jun; 47(6):654-60. Watkin LB, Jessen B, Wiszniewski W, Vece TJ, Jan M, Sha Y, Thamsen M, Santos-Cortez RL, Lee K, Gambin T, Forbes LR, Law CS, Stray-Pedersen A, Cheng MH, Mace EM, Anderson MS, Liu D, Tang LF, Nicholas SK, Nahmod K, Makedonas G, Canter DL, Kwok PY, Hicks J, Jones KD, Penney S, Jhangiani SN, Rosenblum MD, Dell SD, Waterfield MR, Papa FR, Muzny DM, Zaitlen N, Leal SM, Gonzaga-Jauregui C, Baylor-Hopkins Center for Mendelian Genomics, Boerwinkle E, Eissa NT, Gibbs RA, Lupski JR, Orange JS, Shum AK. PMID: 25894502; PMCID: PMC4513663.
      View in: PubMed   Mentions: 148     Fields:    Translation:HumansCells
    22. Protein microarray analysis reveals BAFF-binding autoantibodies in systemic lupus erythematosus. J Clin Invest. 2013 Dec; 123(12):5135-45. Price JV, Haddon DJ, Kemmer D, Delepine G, Mandelbaum G, Jarrell JA, Gupta R, Balboni I, Chakravarty EF, Sokolove J, Shum AK, Anderson MS, Cheng MH, Robinson WH, Browne SK, Holland SM, Baechler EC, Utz PJ. PMID: 24270423; PMCID: PMC3859403.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimals
    23. BPIFB1 is a lung-specific autoantigen associated with interstitial lung disease. Sci Transl Med. 2013 Oct 09; 5(206):206ra139. Shum AK, Alimohammadi M, Tan CL, Cheng MH, Metzger TC, Law CS, Lwin W, Perheentupa J, Bour-Jordan H, Carel JC, Husebye ES, De Luca F, Janson C, Sargur R, Dubois N, Kajosaari M, Wolters PJ, Chapman HA, Kämpe O, Anderson MS. PMID: 24107778; PMCID: PMC3882146.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    24. Prevalence and clinical significance of circulating autoantibodies in idiopathic pulmonary fibrosis. Respir Med. 2013 Feb; 107(2):249-55. Lee JS, Kim EJ, Lynch KL, Elicker B, Ryerson CJ, Katsumoto TR, Shum AK, Wolters PJ, Cerri S, Richeldi L, Jones KD, King TE, Collard HR. PMID: 23186614; PMCID: PMC3543473.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    25. Protein microarray analysis of serum factor-reactive autoantibodies reveals BAFF-binding autoantibodies in systemic lupus erythematosus (58.22). The Journal of Immunology. 2012 May 1; 188(1_Supplement):58.22-58.22. Price PJ, Kemmer KD, Balboni BI, Haddon HD, Mandelbaum MG, Delepine DG, Sokolove SJ, Shum SA, Browne BS, Utz UP. .
      View in: Publisher Site   Mentions:
    26. Defective autoimmune regulator-dependent central tolerance to myelin protein zero is linked to autoimmune peripheral neuropathy. J Immunol. 2012 May 15; 188(10):4906-12. Su MA, Davini D, Cheng P, Giang K, Fan U, DeVoss JJ, Johannes KP, Taylor L, Shum AK, Valenzise M, Meloni A, Bour-Jordan H, Anderson MS. PMID: 22490868; PMCID: PMC3579634.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    27. IgM Antibodies to the Rescue!. Science Translational Medicine. 2012 Feb 22; 4(122). Shum SA. .
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    28. Smoking Out a New Therapy for Lung Disease. Science Translational Medicine. 2012 Jan 25; 4(118). Shum SA. .
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    29. A New Twist in a Fibrous Condition. Science Translational Medicine. 2011 Dec 21; 3(114). Shum SA. .
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    30. A Joint Venture Between Complement and Chondrocytes. Science Translational Medicine. 2011 Nov 23; 3(110). Shum SA. .
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    31. Refreshing Your Memory. Science Translational Medicine. 2011 Oct 26; 3(106). Shum SA. .
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    32. Digesting the Unexpected Side Effects of Chronic Antibiotic Use. Science Translational Medicine. 2011 Sep 28; 3(102). Shum SA. .
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    33. A Gut Check for Asthma. Science Translational Medicine. 2011 Aug 31; 3(98). Shum SA. .
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    34. The "Eyes" Have It. Science Translational Medicine. 2011 Aug 3; 3(94). Shum SA. .
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    35. A Mimic for Lupus Treatment. Science Translational Medicine. 2011 Jul 6; 3(90). Shum SA. .
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    36. Pearls of Wisdom for Pulmonary Fibrosis. Science Translational Medicine. 2011 Jun 8; 3(86). Shum SA. .
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    37. OutFOXing Tolerance in Multiple Sclerosis. Science Translational Medicine. 2011 May 11; 3(82). Shum SA. .
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    38. A Little Tolerance Can Prevent a Broken Heart. Science Translational Medicine. 2011 Apr 13; 3(78). Shum SA. .
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    39. Identification of an autoantigen demonstrates a link between interstitial lung disease and a defect in central tolerance. Sci Transl Med. 2009 Dec 02; 1(9):9ra20. Shum AK, DeVoss J, Tan CL, Hou Y, Johannes K, O'Gorman CS, Jones KD, Sochett EB, Fong L, Anderson MS. PMID: 20368189; PMCID: PMC2856693.
      View in: PubMed   Mentions: 36     Fields:    Translation:Animals
    40. Effector mechanisms of the autoimmune syndrome in the murine model of autoimmune polyglandular syndrome type 1. J Immunol. 2008 Sep 15; 181(6):4072-9. Devoss JJ, Shum AK, Johannes KP, Lu W, Krawisz AK, Wang P, Yang T, Leclair NP, Austin C, Strauss EC, Anderson MS. PMID: 18768863; PMCID: PMC2556863.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    41. A robust immunoassay for anti-interferon autoantibodies that is highly specific for patients with autoimmune polyglandular syndrome type 1. Clin Immunol. 2007 Nov; 125(2):131-7. Zhang L, Barker JM, Babu S, Su M, Stenerson M, Cheng M, Shum A, Zamir E, Badolato R, Law A, Eisenbarth GS, Anderson MS. PMID: 17825626; PMCID: PMC2080870.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    42. What's new in the Aire? Trends Immunol. 2007 Jul; 28(7):321-7. Cheng MH, Shum AK, Anderson MS. PMID: 17556019.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    43. A 36-year-old man with AIDS and relapsing, nonproductive cough. Chest. 2007 Jun; 131(6):1929-31. Davis JL, Shum AK, Huang L. PMID: 17565026.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    44. Aire Deficient Mice—A Model for Autoimmune Lung Disease. Clinical Immunology. 2007 Jan 1; 123:s178. Shum SA, DeVoss DJ, Anderson AM. .
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    45. A surgical method for selecting appropriate size of graft in aortic root remodeling. Ann Thorac Surg. 1999 Feb; 67(2):599-600. Choo SJ, Duran CM. PMID: 10197719.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    46. Selective expansion of Vgamma2-Vdelta7 TCR gammadelta cells in C57BL/6 mice is postnatal and extrathymic. J Immunol. 1997 Jul 01; 159(1):86-91. Sperling AI, Decker DC, DiPaolo RJ, Stern DA, Shum A, Bluestone JA. PMID: 9200442.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
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