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Xiangning Jiang, PhD

Title(s)Associate Professor, Neurology
SchoolSchool of Medicine
Phone415-502-7278
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral StudiesGraduate Division

    Collapse Research 
    Collapse Research Activities and Funding
    Phospho-regulation of NMDA receptors in neonatal brain hypoxia-ischemia
    NIH/NINDS R01NS084057Mar 15, 2014 - Feb 28, 2019
    Role: Principal Investigator
    Src Family Kinases - Mediated Ischemic Neonatal Brain Injury
    NIH/NINDS R21NS059613Jun 1, 2009 - May 31, 2012
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Minnella AM, Zhao JX, Jiang X, Jakobsen E, Lu F, Wu L, El-Benna J, Gray JA, Swanson RA. Excitotoxic superoxide production and neuronal death require both ionotropic and non-ionotropic NMDA receptor signaling. Sci Rep. 2018 Nov 30; 8(1):17522. PMID: 30504838.
      View in: PubMed
    2. Lu F, Zhu J, Guo S, Wong BJ, Chehab FF, Ferriero DM, Jiang X. Upregulation of cholesterol 24-hydroxylase following hypoxia-ischemia in neonatal mouse brain. Pediatr Res. 2018 06; 83(6):1218-1227. PMID: 29718007.
      View in: PubMed
    3. Lu F, Shao G, Wang Y, Guan S, Burlingame AL, Liu X, Liang X, Knox R, Ferriero DM, Jiang X. Hypoxia-ischemia modifies postsynaptic GluN2B-containing NMDA receptor complexes in the neonatal mouse brain. Exp Neurol. 2018 01; 299(Pt A):65-74. PMID: 28993251.
      View in: PubMed
    4. Jiang X, Nardelli J. Cellular and molecular introduction to brain development. Neurobiol Dis. 2016 08; 92(Pt A):3-17. PMID: 26184894.
      View in: PubMed
    5. Knox R, Brennan-Minnella AM, Lu F, Yang D, Nakazawa T, Yamamoto T, Swanson RA, Ferriero DM, Jiang X. NR2B phosphorylation at tyrosine 1472 contributes to brain injury in a rodent model of neonatal hypoxia-ischemia. Stroke. 2014 Oct; 45(10):3040-7. PMID: 25158771; PMCID: PMC4175024.
    6. Sheldon RA, Lee CL, Jiang X, Knox RN, Ferriero DM. Hypoxic preconditioning protection is eliminated in HIF-1a knockout mice subjected to neonatal hypoxia-ischemia. Pediatr Res. 2014 Jul; 76(1):46-53. PMID: 24713818.
      View in: PubMed
    7. Zhu J, Jiang X, Chehab FF. FoxO4 interacts with the sterol regulatory factor SREBP2 and the hypoxia inducible factor HIF2a at the CYP51 promoter. J Lipid Res. 2014 Mar; 55(3):431-42. PMID: 24353279; PMCID: PMC3934728.
    8. Pathipati P, Müller S, Jiang X, Ferriero D. Phenotype and secretory responses to oxidative stress in microglia. Dev Neurosci. 2013; 35(2-3):241-54. PMID: 23548608.
      View in: PubMed
    9. Knox R, Zhao C, Miguel-Perez D, Wang S, Yuan J, Ferriero D, Jiang X. Enhanced NMDA receptor tyrosine phosphorylation and increased brain injury following neonatal hypoxia-ischemia in mice with neuronal Fyn overexpression. Neurobiol Dis. 2013 Mar; 51:113-9. PMID: 23127881.
      View in: PubMed
    10. Jiang X, Knox R, Pathipati P, Ferriero D. Developmental localization of NMDA receptors, Src and MAP kinases in mouse brain. Neurosci Lett. 2011 Oct 10; 503(3):215-9. PMID: 21896318; PMCID: PMC3193348.
    11. Davis B, Tang J, Zhang L, Mu D, Jiang X, Biran V, Vexler Z, Ferriero DM. Role of vasodilator stimulated phosphoprotein in VEGF induced blood-brain barrier permeability in endothelial cell monolayers. Int J Dev Neurosci. 2010 Oct; 28(6):423-8. PMID: 20599605; PMCID: PMC2918884.
    12. Sheldon RA, Osredkar D, Lee CL, Jiang X, Mu D, Ferriero DM. HIF-1 alpha-deficient mice have increased brain injury after neonatal hypoxia-ischemia. Dev Neurosci. 2009; 31(5):452-8. PMID: 19672073.
      View in: PubMed
    13. Chang S, Jiang X, Zhao C, Lee C, Ferriero DM. Exogenous low dose hydrogen peroxide increases hypoxia-inducible factor-1alpha protein expression and induces preconditioning protection against ischemia in primary cortical neurons. Neurosci Lett. 2008 Aug 15; 441(1):134-8. PMID: 18597936.
      View in: PubMed
    14. Jiang X, Mu D, Biran V, Faustino J, Chang S, Rincón CM, Sheldon RA, Ferriero DM. Activated Src kinases interact with the N-methyl-D-aspartate receptor after neonatal brain ischemia. Ann Neurol. 2008 May; 63(5):632-41. PMID: 18384166.
      View in: PubMed
    15. Hamrick SE, McQuillen PS, Jiang X, Mu D, Madan A, Ferriero DM. A role for hypoxia-inducible factor-1alpha in desferoxamine neuroprotection. Neurosci Lett. 2005 May 06; 379(2):96-100. PMID: 15823423.
      View in: PubMed
    16. Jiang X, Mu D, Manabat C, Koshy AA, Christen S, Täuber MG, Vexler ZS, Ferriero DM. Differential vulnerability of immature murine neurons to oxygen-glucose deprivation. Exp Neurol. 2004 Nov; 190(1):224-32. PMID: 15473995.
      View in: PubMed
    17. Sheldon RA, Jiang X, Francisco C, Christen S, Vexler ZS, Täuber MG, Ferriero DM. Manipulation of antioxidant pathways in neonatal murine brain. Pediatr Res. 2004 Oct; 56(4):656-62. PMID: 15295091.
      View in: PubMed
    18. Mu D, Jiang X, Sheldon RA, Fox CK, Hamrick SE, Vexler ZS, Ferriero DM. Regulation of hypoxia-inducible factor 1alpha and induction of vascular endothelial growth factor in a rat neonatal stroke model. Neurobiol Dis. 2003 Dec; 14(3):524-34. PMID: 14678768.
      View in: PubMed
    19. Jiang X, Mu D, Sheldon RA, Glidden DV, Ferriero DM. Neonatal hypoxia-ischemia differentially upregulates MAGUKs and associated proteins in PSD-93-deficient mouse brain. Stroke. 2003 Dec; 34(12):2958-63. PMID: 14605317.
      View in: PubMed