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Patrick McQuillen, MD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentPediatrics
Address1550 Fourth St
San Francisco CA 94158
Phone415-502-4798
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoClinical Fellowship

    Collapse Research 
    Collapse Research Activities and Funding
    Collaborative Research to Validate Biomarkers of Pediatric ARDS
    NIH/NICHD UG1HD083166Dec 24, 2014 - Nov 30, 2019
    Role: Principal Investigator
    Regulation of Cellular Pathwaysin Human Brain Development
    NIH/NINDS P01NS083513Jul 1, 2014 - Jun 30, 2019
    Role: Co-Investigator
    Repair after Neonatal Brain Injury
    NIH/NINDS P01NS082330Jan 1, 2014 - Dec 31, 2018
    Role: Principal Investigator
    White Matter Injury in Critical Ill Newborns With Congenital Heart Disease
    NIH/NINDS R01NS063876Sep 30, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Critical Period Plasticity Following Neonatal Brain Injury
    NIH/NINDS R01NS060896Dec 1, 2007 - May 31, 2018
    Role: Principal Investigator
    Selective subplate vulnerability and cortical plasticity
    NIH/NINDS K02NS047098Sep 20, 2004 - Jun 30, 2009
    Role: Principal Investigator
    SUBPLATE NEURONS AND EARLY HYPOXIC ISCHEMIC BRAIN INJURY
    NIH/NICHD K08HD001396Aug 4, 2000 - Jun 30, 2004
    Role: Principal Investigator
    PEDIATRIC CLINICAL RESEARCH CENTER
    NIH/NCRR M01RR001271Dec 1, 1981 - Mar 31, 2007
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Peyvandi S, Latal B, Miller SP, McQuillen P. The neonatal brain in critical congenital heart disease: Insights and future directions. Neuroimage. 2018 May 19. PMID: 29787864.
      View in: PubMed
    2. Peyvandi S, Chau V, Guo T, Xu D, Glass HC, Synnes A, Poskitt K, Barkovich AJ, Miller SP, McQuillen P. Neonatal Brain Injury and Timing of Neurodevelopmental Assessment in Patients With Congenital Heart Disease. J Am Coll Cardiol. 2018 May 08; 71(18):1986-1996. PMID: 29724352.
      View in: PubMed
    3. Reeder RW, Girling A, Wolfe H, Holubkov R, Berg RA, Naim MY, Meert KL, Tilford B, Carcillo JA, Hamilton M, Bochkoris M, Hall M, Maa T, Yates AR, Sapru A, Kelly R, Federman M, Michael Dean J, McQuillen P, Franzon D, Pollack MM, Siems A, Diddle J, Wessel DL, Mourani PM, Zebuhr C, Bishop R, Friess S, Burns C, Viteri S, Hehir DA, Whitney Coleman R, Jenkins TL, Notterman DA, Tamburro RF, Sutton RM. Improving outcomes after pediatric cardiac arrest - the ICU-Resuscitation Project: study protocol for a randomized controlled trial. Trials. 2018 Apr 03; 19(1):213. PMID: 29615134.
      View in: PubMed
    4. Sheikh A, Meng X, Liu J, Mikhailova A, Kao JPY, McQuillen P, Kanold PO. Neonatal Hypoxia-Ischemia Causes Functional Circuit Changes in Subplate Neurons. Cereb Cortex. 2018 Jan 20. PMID: 29365081.
      View in: PubMed
    5. Berg RA, Sutton RM, Reeder RW, Berger JT, Newth CJ, Carcillo JA, McQuillen P, Meert KL, Yates AR, Harrison RE, Moler FW, Pollack MM, Carpenter TC, Wessel DL, Jenkins TL, Notterman DA, Holubkov R, Tamburro RF, Dean JM, Nadkarni VM. Association Between Diastolic Blood Pressure During Pediatric In-Hospital Cardiopulmonary Resuscitation and Survival. Circulation. 2017 Dec 26. PMID: 29279413.
      View in: PubMed
    6. Zinter MS, Holubkov R, Steurer MA, Dvorak CC, Duncan CN, Sapru A, Tamburro RF, McQuillen P, Pollack MM. Pediatric Hematopoietic Cell Transplant Patients Who Survive Critical Illness Frequently Have Significant but Recoverable Decline in Functional Status. Biol Blood Marrow Transplant. 2018 Feb; 24(2):330-336. PMID: 29128553.
      View in: PubMed
    7. Peyvandi S, Kim H, Lau J, Barkovich AJ, Campbell A, Miller S, Xu D, McQuillen P. The association between cardiac physiology, acquired brain injury, and postnatal brain growth in critical congenital heart disease. J Thorac Cardiovasc Surg. 2018 Jan; 155(1):291-300.e3. PMID: 28918207.
      View in: PubMed
    8. Mikhailova A, Sunkara N, McQuillen P. Unbiased Quantification of Subplate Neuron Loss following Neonatal Hypoxia-Ischemia in a Rat Model. Dev Neurosci. 2017; 39(1-4):171-181. PMID: 28434006.
      View in: PubMed
    9. Moler FW, Silverstein FS, Holubkov R, Slomine BS, Christensen JR, Nadkarni VM, Meert KL, Browning B, Pemberton VL, Page K, Gildea MR, Scholefield BR, Shankaran S, Hutchison JS, Berger JT, Ofori-Amanfo G, Newth CJ, Topjian A, Bennett KS, Koch JD, Pham N, Chanani NK, Pineda JA, Harrison R, Dalton HJ, Alten J, Schleien CL, Goodman DM, Zimmerman JJ, Bhalala US, Schwarz AJ, Porter MB, Shah S, Fink EL, McQuillen P, Wu T, Skellett S, Thomas NJ, Nowak JE, Baines PB, Pappachan J, Mathur M, Lloyd E, van der Jagt EW, Dobyns EL, Meyer MT, Sanders RC, Clark AE, Dean JM. Therapeutic Hypothermia after In-Hospital Cardiac Arrest in Children. N Engl J Med. 2017 01 26; 376(4):318-329. PMID: 28118559.
      View in: PubMed
    10. Agus MS, Wypij D, Hirshberg EL, Srinivasan V, Faustino EV, Luckett PM, Alexander JL, Asaro LA, Curley MA, Steil GM, Nadkarni VM. Tight Glycemic Control in Critically Ill Children. N Engl J Med. 2017 02 23; 376(8):729-741. PMID: 28118549.
      View in: PubMed
    11. Meert KL, Telford R, Holubkov R, Slomine BS, Christensen JR, Dean JM, Moler FW. Pediatric Out-of-Hospital Cardiac Arrest Characteristics and Their Association With Survival and Neurobehavioral Outcome. Pediatr Crit Care Med. 2016 Dec; 17(12):e543-e550. PMID: 27679965.
      View in: PubMed
    12. Silverstein FS, Slomine BS, Christensen J, Holubkov R, Page K, Dean JM, Moler FW. Functional Outcome Trajectories After Out-of-Hospital Pediatric Cardiac Arrest. Crit Care Med. 2016 Dec; 44(12):e1165-e1174. PMID: 27509385.
      View in: PubMed
    13. Paredes MF, James D, Gil-Perotin S, Kim H, Cotter JA, Ng C, Sandoval K, Rowitch DH, Xu D, McQuillen P, Garcia-Verdugo JM, Huang EJ, Alvarez-Buylla A. Extensive migration of young neurons into the infant human frontal lobe. Science. 2016 Oct 07; 354(6308). PMID: 27846470.
      View in: PubMed
    14. Impact of Operative and Postoperative Factors on Neurodevelopmental Outcomes After Cardiac Operations. Ann Thorac Surg. 2016 Sep; 102(3):843-849. PMID: 27496628.
      View in: PubMed
    15. Moler FW, Hutchison JS, Nadkarni VM, Silverstein FS, Meert KL, Holubkov R, Page K, Slomine BS, Christensen JR, Dean JM. Targeted Temperature Management After Pediatric Cardiac Arrest Due To Drowning: Outcomes and Complications. Pediatr Crit Care Med. 2016 Aug; 17(8):712-20. PMID: 27362855.
      View in: PubMed
    16. Peyvandi S, De Santiago V, Chakkarapani E, Chau V, Campbell A, Poskitt KJ, Xu D, Barkovich AJ, Miller S, McQuillen P. Association of Prenatal Diagnosis of Critical Congenital Heart Disease With Postnatal Brain Development and the Risk of Brain Injury. JAMA Pediatr. 2016 Apr; 170(4):e154450. PMID: 26902528.
      View in: PubMed
    17. Ranasinghe S, Or G, Wang EY, Ievins A, McLean MA, Niell CM, Chau V, Wong PK, Glass HC, Sullivan J, McQuillen P. Reduced Cortical Activity Impairs Development and Plasticity after Neonatal Hypoxia Ischemia. J Neurosci. 2015 Aug 26; 35(34):11946-59. PMID: 26311776; PMCID: PMC4549405.
    18. Gaynor JW, Stopp C, Wypij D, Andropoulos DB, Atallah J, Atz AM, Beca J, Donofrio MT, Duncan K, Ghanayem NS, Goldberg CS, Hövels-Gürich H, Ichida F, Jacobs JP, Justo R, Latal B, Li JS, Mahle WT, McQuillen P, Menon SC, Pemberton VL, Pike NA, Pizarro C, Shekerdemian LS, Synnes A, Williams I, Bellinger DC, Newburger JW. Neurodevelopmental outcomes after cardiac surgery in infancy. Pediatrics. 2015 May; 135(5):816-25. PMID: 25917996; PMCID: PMC4533222.
    19. Moler FW, Silverstein FS, Holubkov R, Slomine BS, Christensen JR, Nadkarni VM, Meert KL, Clark AE, Browning B, Pemberton VL, Page K, Shankaran S, Hutchison JS, Newth CJ, Bennett KS, Berger JT, Topjian A, Pineda JA, Koch JD, Schleien CL, Dalton HJ, Ofori-Amanfo G, Goodman DM, Fink EL, McQuillen P, Zimmerman JJ, Thomas NJ, van der Jagt EW, Porter MB, Meyer MT, Harrison R, Pham N, Schwarz AJ, Nowak JE, Alten J, Wheeler DS, Bhalala US, Lidsky K, Lloyd E, Mathur M, Shah S, Wu T, Theodorou AA, Sanders RC, Dean JM. Therapeutic hypothermia after out-of-hospital cardiac arrest in children. N Engl J Med. 2015 May 14; 372(20):1898-908. PMID: 25913022; PMCID: PMC4470472.
    20. Algra SO, Haas F, Poskitt KJ, Groenendaal F, Schouten AN, Jansen NJ, Azakie A, Gandhi S, Campbell A, Miller SP, McQuillen P, de Vries LS. Minimizing the risk of preoperative brain injury in neonates with aortic arch obstruction. J Pediatr. 2014 Dec; 165(6):1116-1122.e3. PMID: 25306190; PMCID: PMC4624274.
    21. Oishi PE, Klein OD, Keller RL. Developing physician-scientists in the fields of neonatology and pediatric critical care medicine: an effort to formulate a departmental policy. J Pediatr. 2013 Sep; 163(3):616-7.e1. PMID: 23973233.
      View in: PubMed
    22. Dimitropoulos A, McQuillen P, Sethi V, Moosa A, Chau V, Xu D, Brant R, Azakie A, Campbell A, Barkovich AJ, Poskitt KJ, Miller SP. Brain injury and development in newborns with critical congenital heart disease. Neurology. 2013 Jul 16; 81(3):241-8. PMID: 23771484; PMCID: PMC3770166.
    23. Sethi V, Tabbutt S, Dimitropoulos A, Harris KC, Chau V, Poskitt K, Campbell A, Azakie A, Xu D, Barkovich AJ, Miller SP, McQuillen P. Single-ventricle anatomy predicts delayed microstructural brain development. Pediatr Res. 2013 May; 73(5):661-7. PMID: 23407116; PMCID: PMC3631295.
    24. Gonzalez FF, Larpthaveesarp A, McQuillen P, Derugin N, Wendland M, Spadafora R, Ferriero DM. Erythropoietin increases neurogenesis and oligodendrogliosis of subventricular zone precursor cells after neonatal stroke. Stroke. 2013 Mar; 44(3):753-8. PMID: 23391775; PMCID: PMC3689426.
    25. Tymofiyeva O, Hess CP, Ziv E, Tian N, Bonifacio SL, McQuillen P, Ferriero DM, Barkovich AJ, Xu D. Towards the "baby connectome": mapping the structural connectivity of the newborn brain. PLoS One. 2012; 7(2):e31029. PMID: 22347423; PMCID: PMC3274551.
    26. Costello JM, McQuillen P, Claud EC, Steinhorn RH. Prematurity and congenital heart disease. World J Pediatr Congenit Heart Surg. 2011 Jul 01; 2(3):457-67. PMID: 23803997.
      View in: PubMed
    27. Glass HC, Bowman C, Chau V, Moosa A, Hersh AL, Campbell A, Poskitt K, Azakie A, Barkovich AJ, Miller SP, McQuillen P. Infection and white matter injury in infants with congenital cardiac disease. Cardiol Young. 2011 Oct; 21(5):562-71. PMID: 21554828; PMCID: PMC3171591.
    28. Cramer SC, Sur M, Dobkin BH, O'Brien C, Sanger TD, Trojanowski JQ, Rumsey JM, Hicks R, Cameron J, Chen D, Chen WG, Cohen LG, deCharms C, Duffy CJ, Eden GF, Fetz EE, Filart R, Freund M, Grant SJ, Haber S, Kalivas PW, Kolb B, Kramer AF, Lynch M, Mayberg HS, McQuillen P, Nitkin R, Pascual-Leone A, Reuter-Lorenz P, Schiff N, Sharma A, Shekim L, Stryker M, Sullivan EV, Vinogradov S. Harnessing neuroplasticity for clinical applications. Brain. 2011 Jun; 134(Pt 6):1591-609. PMID: 21482550; PMCID: PMC3102236.
    29. Azakie A, Johnson NC, Anagnostopoulos PV, Akram SM, McQuillen P, Sapru A. Stage II palliation of hypoplastic left heart syndrome without cardiopulmonary bypass. J Thorac Cardiovasc Surg. 2011 Feb; 141(2):400-6. PMID: 21241860.
      View in: PubMed
    30. Corbett-Detig J, Habas PA, Scott JA, Kim K, Rajagopalan V, McQuillen P, Barkovich AJ, Glenn OA, Studholme C. 3D global and regional patterns of human fetal subplate growth determined in utero. Brain Struct Funct. 2011 Jan; 215(3-4):255-63. PMID: 21046152; PMCID: PMC3041913.
    31. Block AJ, McQuillen P, Chau V, Glass H, Poskitt KJ, Barkovich AJ, Esch M, Soulikias W, Azakie A, Campbell A, Miller SP. Clinically silent preoperative brain injuries do not worsen with surgery in neonates with congenital heart disease. J Thorac Cardiovasc Surg. 2010 Sep; 140(3):550-7. PMID: 20434174; PMCID: PMC2917479.
    32. McQuillen P, Goff DA, Licht DJ. Effects of congenital heart disease on brain development. Prog Pediatr Cardiol. 2010 Aug 01; 29(2):79-85. PMID: 20802830.
      View in: PubMed
    33. Zuluaga MT, Esch ME, Cvijanovich NZ, Gupta N, McQuillen P. Diagnosis influences response of cerebral near infrared spectroscopy to intracranial hypertension in children. Pediatr Crit Care Med. 2010 Jul; 11(4):514-22. PMID: 19935441; PMCID: PMC3675803.
    34. Kaltman JR, Andropoulos DB, Checchia PA, Gaynor JW, Hoffman TM, Laussen PC, Ohye RG, Pearson GD, Pigula F, Tweddell J, Wernovsky G, Del Nido P. Report of the pediatric heart network and national heart, lung, and blood institute working group on the perioperative management of congenital heart disease. Circulation. 2010 Jun 29; 121(25):2766-72. PMID: 20585021.
      View in: PubMed
    35. Spadafora R, Gonzalez FF, Derugin N, Wendland M, Ferriero D, McQuillen P. Altered fate of subventricular zone progenitor cells and reduced neurogenesis following neonatal stroke. Dev Neurosci. 2010 Jul; 32(2):101-13. PMID: 20453463.
      View in: PubMed
    36. Arnold TD, McQuillen P. From death to recovery following hypoxia ischemia: if TGFbeta is a central regulator, is integrin beta8 the switch? Neurotox Res. 2010 May; 17(4):418-20. PMID: 20039156; PMCID: PMC2835727.
    37. Berman JI, Hamrick SE, McQuillen P, Studholme C, Xu D, Henry RG, Hornberger LK, Glenn OA. Diffusion-weighted imaging in fetuses with severe congenital heart defects. AJNR Am J Neuroradiol. 2011 Feb; 32(2):E21-2. PMID: 20075085.
      View in: PubMed
    38. Failor S, Nguyen V, Darcy DP, Cang J, Wendland MF, Stryker MP, McQuillen P. Neonatal cerebral hypoxia-ischemia impairs plasticity in rat visual cortex. J Neurosci. 2010 Jan 06; 30(1):81-92. PMID: 20053890; PMCID: PMC2822440.
    39. McQuillen P, Miller SP. Congenital heart disease and brain development. Ann N Y Acad Sci. 2010 Jan; 1184:68-86. PMID: 20146691.
      View in: PubMed
    40. Nguyen V, McQuillen P. AMPA and metabotropic excitoxicity explain subplate neuron vulnerability. Neurobiol Dis. 2010 Jan; 37(1):195-207. PMID: 19822212; PMCID: PMC2789448.
    41. McQuillen P. Magnetic resonance imaging in congenital heart disease: what to do with what we see and don't see? Circulation. 2009 Feb 10; 119(5):660-2. PMID: 19204316.
      View in: PubMed
    42. Sherlock RL, McQuillen P, Miller SP. Preventing brain injury in newborns with congenital heart disease: brain imaging and innovative trial designs. Stroke. 2009 Jan; 40(1):327-32. PMID: 18988911.
      View in: PubMed
    43. Miller SP, McQuillen P, Hamrick S, Xu D, Glidden DV, Charlton N, Karl T, Azakie A, Ferriero DM, Barkovich AJ, Vigneron DB. Abnormal brain development in newborns with congenital heart disease. N Engl J Med. 2007 Nov 08; 357(19):1928-38. PMID: 17989385.
      View in: PubMed
    44. Miller SP, McQuillen P. Neurology of congenital heart disease: insight from brain imaging. Arch Dis Child Fetal Neonatal Ed. 2007 Nov; 92(6):F435-7. PMID: 17848505; PMCID: PMC2675385.
    45. McQuillen P, Nishimoto MS, Bottrell CL, Fineman LD, Hamrick SE, Glidden DV, Azakie A, Adatia I, Miller SP. Regional and central venous oxygen saturation monitoring following pediatric cardiac surgery: concordance and association with clinical variables. Pediatr Crit Care Med. 2007 Mar; 8(2):154-60. PMID: 17273125.
      View in: PubMed
    46. McQuillen P, Barkovich AJ, Hamrick SE, Perez M, Ward P, Glidden DV, Azakie A, Karl T, Miller SP. Temporal and anatomic risk profile of brain injury with neonatal repair of congenital heart defects. Stroke. 2007 Feb; 38(2 Suppl):736-41. PMID: 17261728.
      View in: PubMed
    47. Gonzalez FF, McQuillen P, Mu D, Chang Y, Wendland M, Vexler Z, Ferriero DM. Erythropoietin enhances long-term neuroprotection and neurogenesis in neonatal stroke. Dev Neurosci. 2007; 29(4-5):321-30. PMID: 17762200.
      View in: PubMed
    48. Partridge SC, Vigneron DB, Charlton NN, Berman JI, Henry RG, Mukherjee P, McQuillen P, Karl TR, Barkovich AJ, Miller SP. Pyramidal tract maturation after brain injury in newborns with heart disease. Ann Neurol. 2006 Apr; 59(4):640-51. PMID: 16450369.
      View in: PubMed
    49. McQuillen P, Hamrick SE, Perez MJ, Barkovich AJ, Glidden DV, Karl TR, Teitel D, Miller SP. Balloon atrial septostomy is associated with preoperative stroke in neonates with transposition of the great arteries. Circulation. 2006 Jan 17; 113(2):280-5. PMID: 16401771.
      View in: PubMed
    50. Azakie A, Muse J, Gardner M, Skidmore KL, Miller SP, Karl TR, McQuillen P. Cerebral oxygen balance is impaired during repair of aortic coarctation in infants and children. J Thorac Cardiovasc Surg. 2005 Sep; 130(3):830-6. PMID: 16153936.
      View in: PubMed
    51. McQuillen P, Ferriero DM. Perinatal subplate neuron injury: implications for cortical development and plasticity. Brain Pathol. 2005 Jul; 15(3):250-60. PMID: 16196392.
      View in: PubMed
    52. Zhao C, Avilés C, Abel RA, Almli CR, McQuillen P, Pleasure SJ. Hippocampal and visuospatial learning defects in mice with a deletion of frizzled 9, a gene in the Williams syndrome deletion interval. Development. 2005 Jun; 132(12):2917-27. PMID: 15930120.
      View in: PubMed
    53. Hamrick SE, McQuillen P, Jiang X, Mu D, Madan A, Ferriero DM. A role for hypoxia-inducible factor-1alpha in desferoxamine neuroprotection. Neurosci Lett. 2005 May 06; 379(2):96-100. PMID: 15823423.
      View in: PubMed
    54. Chang YS, Mu D, Wendland M, Sheldon RA, Vexler ZS, McQuillen P, Ferriero DM. Erythropoietin improves functional and histological outcome in neonatal stroke. Pediatr Res. 2005 Jul; 58(1):106-11. PMID: 15879287.
      View in: PubMed
    55. Miller SP, McQuillen P, Vigneron DB, Glidden DV, Barkovich AJ, Ferriero DM, Hamrick SE, Azakie A, Karl TR. Preoperative brain injury in newborns with transposition of the great arteries. Ann Thorac Surg. 2004 May; 77(5):1698-706. PMID: 15111170.
      View in: PubMed
    56. McQuillen P, Ferriero DM. Selective vulnerability in the developing central nervous system. Pediatr Neurol. 2004 Apr; 30(4):227-35. PMID: 15087099.
      View in: PubMed
    57. McQuillen P, Sheldon RA, Shatz CJ, Ferriero DM. Selective vulnerability of subplate neurons after early neonatal hypoxia-ischemia. J Neurosci. 2003 Apr 15; 23(8):3308-15. PMID: 12716938.
      View in: PubMed
    58. McQuillen P, DeFreitas MF, Zada G, Shatz CJ. A novel role for p75NTR in subplate growth cone complexity and visual thalamocortical innervation. J Neurosci. 2002 May 01; 22(9):3580-93. PMID: 11978834.
      View in: PubMed
    59. DeFreitas MF, McQuillen P, Shatz CJ. A novel p75NTR signaling pathway promotes survival, not death, of immunopurified neocortical subplate neurons. J Neurosci. 2001 Jul 15; 21(14):5121-9. PMID: 11438587.
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    60. Lein ES, Finney EM, McQuillen P, Shatz CJ. Subplate neuron ablation alters neurotrophin expression and ocular dominance column formation. Proc Natl Acad Sci U S A. 1999 Nov 09; 96(23):13491-5. PMID: 10557348; PMCID: PMC23975.