 Akiko Hata, PhD
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| Title | Professor in Residence |
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| School | UCSF School of Medicine |
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| Department | Cardiovascular Research Institute |
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| Address | 555 Mission Bay Blvd South
San Francisco CA 94158
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| Phone | 415-476-9758 |
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 Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Blahna MT, Hata A. Regulation of miRNA biogenesis as an integrated component of growth factor signaling. Curr Opin Cell Biol. 2013 Apr; 25(2):233-40.
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Iijima S, Shinoki K, Ibata T, Nakashita C, Doi S, Hidaka K, Hata A, Matsuoka M, Waguchi H, Mito S, Komuro R. [Local Communalization of Clinical Records between the Municipal Community Hospital and Local Medical Institutes by Using Information Technology]. Gan To Kagaku Ryoho. 2012 Dec; 39(12):12-4.
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Waguchi H, Hidaka K, Shinoki K, Matsuoka M, Mito S, Doi S, Hata A, Ibata T, Komuro R, Iijima S. [The Trend of Nutritional Management in a Survey of Nutrient Intake, via Gastrostomy, in Patients Following an Acute Hospital Stay]. Gan To Kagaku Ryoho. 2012 Dec; 39(12):95-7.
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Hidaka K, Waguchi H, Shinoki K, Matsuoka M, Mito S, Doi S, Hata A, Ibata T, Komuro R, Iijima S. [A survey on nutritional management planning for patients attending an another institute after discharge]. Gan To Kagaku Ryoho. 2012 Dec; 39(12):86-8.
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Doi S, Mito S, Iida Y, Shinomiya S, Ibata T, Shinoki K, Nakashita C, Matsuoka M, Hata A, Komuro R, Iijima S. [Home-based infusion therapy by broviac catheter after total parenteral nutrition therapy in a patient with a severe skin condition]. Gan To Kagaku Ryoho. 2012 Dec; 39(12):55-7.
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Ibata T, Hidaka K, Shinoki K, Matsuoka M, Hata A, Nakashita C, Mito S, Doi S, Komuro R, Iijima S. [A regional alliance in nutritional management-ten years of collaboration with an nutrition support team network]. Gan To Kagaku Ryoho. 2012 Dec; 39(12):18-20.
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Hata A. Functions of MicroRNAs in Cardiovascular Biology and Disease. Annu Rev Physiol. 2013 Feb 10; 75:69-93.
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Akhurst RJ, Hata A. Targeting the TGFß signalling pathway in disease. Nat Rev Drug Discov. 2012 Oct; 11(10):790-811.
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Kang H, Louie J, Weisman A, Sheu-Gruttadauria J, Davis-Dusenbery BN, Lagna G, Hata A. Inhibition of MicroRNA-302 (miR-302) by Bone Morphogenetic Protein 4 (BMP4) Facilitates the BMP Signaling Pathway. J Biol Chem. 2012 Nov 9; 287(46):38656-64.
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Wang D, Prakash J, Nguyen P, Davis-Dusenbery BN, Hill NS, Layne MD, Hata A, Lagna G. Bone morphogenetic protein signaling in vascular disease: anti-inflammatory action through myocardin-related transcription factor A. J Biol Chem. 2012 Aug 10; 287(33):28067-77.
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Kang H, Hata A. MicroRNA regulation of smooth muscle gene expression and phenotype. Curr Opin Hematol. 2012 May; 19(3):224-31.
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Hata A, Brivanlou AH. A taste of TGFß in Tuscany. Development. 2012 Feb; 139(3):449-53.
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Blahna MT, Hata A. Smad-mediated regulation of microRNA biosynthesis. FEBS Lett. 2012 Jul 4; 586(14):1906-12.
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Kang H, Davis-Dusenbery BN, Nguyen PH, Lal A, Lieberman J, Van Aelst L, Lagna G, Hata A. Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins. J Biol Chem. 2012 Feb 3; 287(6):3976-86.
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McDonald RA, Hata A, MacLean MR, Morrell NW, Baker AH. MicroRNA and vascular remodelling in acute vascular injury and pulmonary vascular remodelling. Cardiovasc Res. 2012 Mar 15; 93(4):594-604.
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Davis-Dusenbery BN, Wu C, Hata A. Micromanaging vascular smooth muscle cell differentiation and phenotypic modulation. Arterioscler Thromb Vasc Biol. 2011 Nov; 31(11):2370-7.
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Wu C, So J, Davis-Dusenbery BN, Qi HH, Bloch DB, Shi Y, Lagna G, Hata A. Hypoxia potentiates microRNA-mediated gene silencing through posttranslational modification of Argonaute2. Mol Cell Biol. 2011 Dec; 31(23):4760-74.
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Davis-Dusenbery BN, Chan MC, Reno KE, Weisman AS, Layne MD, Lagna G, Hata A. down-regulation of Kruppel-like factor-4 (KLF4) by microRNA-143/145 is critical for modulation of vascular smooth muscle cell phenotype by transforming growth factor-beta and bone morphogenetic protein 4. J Biol Chem. 2011 Aug 12; 286(32):28097-110.
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Hata A, Davis BN. Regulation of pri-miRNA Processing Through Smads. Adv Exp Med Biol. 2011; 700:15-27.
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Davis-Dusenbery BN, Hata A. Smad-mediated miRNA processing: a critical role for a conserved RNA sequence. RNA Biol. 2011 Jan-Feb; 8(1):71-6.
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Chan MC, Weisman AS, Kang H, Nguyen PH, Hickman T, Mecker SV, Hill NS, Lagna G, Hata A. The amiloride derivative phenamil attenuates pulmonary vascular remodeling by activating NFAT and the bone morphogenetic protein signaling pathway. Mol Cell Biol. 2011 Feb; 31(3):517-30.
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Hata A, Ibata T, Shinoki K, Ando Y, Hirata T, Kojima A, Nishijima R, Doi S, Komuro R, Iijima S. [The use of total enteral formula with enriched nutrient in home Low Calorie Diet(LCD)therapy based on regular meal]. Gan To Kagaku Ryoho. 2010 Dec; 37 Suppl 2:278-80.
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Shinoki K, Hata A, Satou M, Nakashita C, Doi S, Mito S, Ibata T, Komuro R, Iijima S. [The follow-up study of patients with NST discharge summary for a continuous nutritional management]. Gan To Kagaku Ryoho. 2010 Dec; 37 Suppl 2:281-3.
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Ibata T, Hinokiyama H, Nakashita C, Mito S, Doi S, Shiki S, Hata A, Sato M, Komuro R, Iijima H. [Two elderly case reports of renal excretion type drug poisoning caused by dehydration that was due to poor eating in home care]. Gan To Kagaku Ryoho. 2010 Dec; 37 Suppl 2:224-6.
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Doi S, Iwai A, Mito S, Utsumi T, Shinoki K, Nakashita C, Hata A, Ibata T, Komuro R, Iijima A. [The importance of Dysphagia management during the peri-operative period to home elderly care]. Gan To Kagaku Ryoho. 2010 Dec; 37 Suppl 2:221-3.
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Nakashita C, Hinokiyama H, Shinoki K, Mito S, Doi S, Hata A, Hidaka K, Yamakura H, Ibata T, Komuro R, Iijima S. [The management for safety on Home Parenteral Nutrition(HPN)]. Gan To Kagaku Ryoho. 2010 Dec; 37 Suppl 2:287-9.
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Ibata T, Hata A, Shinoki K, Nishijima R, Mito S, Doi S, Nakashita C, Komuro R, Iijima S. [A case of severe obese patient complicated with type-2 diabetes--transition from Very Low Calorie Diet(VLCD) therapy to Low Calorie Diet(LCD)therapy]. Gan To Kagaku Ryoho. 2010 Dec; 37 Suppl 2:272-4.
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Davis-Dusenbery BN, Hata A. MicroRNA in Cancer: The Involvement of Aberrant MicroRNA Biogenesis Regulatory Pathways. Genes Cancer. 2010 Nov; 1(11):1100-14.
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Li Q, Hata A, Kosugi C, Kataoka N, Funaki M. The density of extracellular matrix proteins regulates inflammation and insulin signaling in adipocytes. FEBS Lett. 2010 Oct 8; 584(19):4145-50.
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Davis-Dusenbery BN, Hata A. Mechanisms of control of microRNA biogenesis. J Biochem. 2010 Oct; 148(4):381-92.
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Davis BN, Hilyard AC, Nguyen PH, Lagna G, Hata A. Smad proteins bind a conserved RNA sequence to promote microRNA maturation by Drosha. Mol Cell. 2010 Aug 13; 39(3):373-84.
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Hata A, Davis BN. Regulation of pri-miRNA processing through Smads. Adv Exp Med Biol. 2010; 700:15-27.
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Chan MC, Hilyard AC, Wu C, Davis BN, Hill NS, Lal A, Lieberman J, Lagna G, Hata A. Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression. EMBO J. 2010 Feb 3; 29(3):559-73.
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Hata A, Davis BN. Control of microRNA biogenesis by TGFbeta signaling pathway-A novel role of Smads in the nucleus. Cytokine Growth Factor Rev. 2009 Oct-Dec; 20(5-6):517-21.
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Davis BN, Hata A. Regulation of MicroRNA Biogenesis: A miRiad of mechanisms. Cell Commun Signal. 2009; 7:18.
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Huang S, Laoukili J, Epping MT, Koster J, Hölzel M, Westerman BA, Nijkamp W, Hata A, Asgharzadeh S, Seeger RC, Versteeg R, Beijersbergen RL, Bernards R. ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome. Cancer Cell. 2009 Apr 7; 15(4):328-40.
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Neuman NA, Ma S, Schnitzler GR, Zhu Y, Lagna G, Hata A. The four-and-a-half LIM domain protein 2 regulates vascular smooth muscle phenotype and vascular tone. J Biol Chem. 2009 May 8; 284(19):13202-12.
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Davis BN, Hilyard AC, Nguyen PH, Lagna G, Hata A. Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype. J Biol Chem. 2009 Feb 6; 284(6):3728-38.
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Yamazaki K, Takahashi A, Takazoe M, Kubo M, Onouchi Y, Fujino A, Kamatani N, Nakamura Y, Hata A. Positive association of genetic variants in the upstream region of NKX2-3 with Crohn's disease in Japanese patients. Gut. 2009 Feb; 58(2):228-32.
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Davis BN, Hilyard AC, Lagna G, Hata A. SMAD proteins control DROSHA-mediated microRNA maturation. Nature. 2008 Jul 3; 454(7200):56-61.
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Lagna G, Ku MM, Nguyen PH, Neuman NA, Davis BN, Hata A. Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors. J Biol Chem. 2007 Dec 21; 282(51):37244-55.
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Nakaya Y, Mawatari K, Takahashi A, Harada N, Hata A, Yasui S. The phytoestrogen ginsensoside Re activates potassium channels of vascular smooth muscle cells through PI3K/Akt and nitric oxide pathways. J Med Invest. 2007 Aug; 54(3-4):381-4.
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Chan MC, Nguyen PH, Davis BN, Ohoka N, Hayashi H, Du K, Lagna G, Hata A. A novel regulatory mechanism of the bone morphogenetic protein (BMP) signaling pathway involving the carboxyl-terminal tail domain of BMP type II receptor. Mol Cell Biol. 2007 Aug; 27(16):5776-89.
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Lagna G, Nguyen PH, Ni W, Hata A. BMP-dependent activation of caspase-9 and caspase-8 mediates apoptosis in pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2006 Nov; 291(5):L1059-67.
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Inoue M, Hata A, Suzuki A, Nohara M, Shikazono N, Yim WW, Hantoro WS, Donghuai S, Kawahata H. Distribution and temporal changes of lead in the surface seawater in the western Pacific and adjacent seas derived from coral skeletons. Environ Pollut. 2006 Dec; 144(3):1045-52.
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Ku M, Howard S, Ni W, Lagna G, Hata A. OAZ regulates bone morphogenetic protein signaling through Smad6 activation. J Biol Chem. 2006 Feb 24; 281(8):5277-87.
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Ku M, Sokol SY, Wu J, Tussie-Luna MI, Roy AL, Hata A. Positive and negative regulation of the transforming growth factor beta/activin target gene goosecoid by the TFII-I family of transcription factors. Mol Cell Biol. 2005 Aug; 25(16):7144-57.
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Ohmori H, Ando Y, Makita Y, Onouchi Y, Nakajima T, Saraiva MJ, Terazaki H, Suhr O, Sobue G, Nakamura M, Yamaizumi M, Munar-Ques M, Inoue I, Uchino M, Hata A. Common origin of the Val30Met mutation responsible for the amyloidogenic transthyretin type of familial amyloidotic polyneuropathy. J Med Genet. 2004 Apr; 41(4):e51.
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Seki K, Hata A. Indian hedgehog gene is a target of the bone morphogenetic protein signaling pathway. J Biol Chem. 2004 Apr 30; 279(18):18544-9.
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Ku MC, Stewart S, Hata A. Poly(ADP-ribose) polymerase 1 interacts with OAZ and regulates BMP-target genes. Biochem Biophys Res Commun. 2003 Nov 21; 311(3):702-7.
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Bond HM, Mesuraca M, Carbone E, Bonelli P, Agosti V, Amodio N, De Rosa G, Di Nicola M, Gianni AM, Moore MA, Hata A, Grieco M, Morrone G, Venuta S. Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells. Blood. 2004 Mar 15; 103(6):2062-70.
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Seki K, Fujimori T, Savagner P, Hata A, Aikawa T, Ogata N, Nabeshima Y, Kaechoong L. Mouse Snail family transcription repressors regulate chondrocyte, extracellular matrix, type II collagen, and aggrecan. J Biol Chem. 2003 Oct 24; 278(43):41862-70.
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Hata A. TGFbeta signaling and cancer. Exp Cell Res. 2001 Mar 10; 264(1):111-6.
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Iwashima Y, Eto M, Hata A, Kaku K, Horiuchi S, Ushikubi F, Sano H. Advanced glycation end products-induced gene expression of scavenger receptors in cultured human monocyte-derived macrophages. Biochem Biophys Res Commun. 2000 Oct 22; 277(2):368-80.
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Hata A, Seoane J, Lagna G, Montalvo E, Hemmati-Brivanlou A, Massagué J. OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways. Cell. 2000 Jan 21; 100(2):229-40.
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Oike Y, Takakura N, Hata A, Kaname T, Akizuki M, Yamaguchi Y, Yasue H, Araki K, Yamamura K, Suda T. Mice homozygous for a truncated form of CREB-binding protein exhibit defects in hematopoiesis and vasculo-angiogenesis. Blood. 1999 May 1; 93(9):2771-9.
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Oike Y, Hata A, Mamiya T, Kaname T, Noda Y, Suzuki M, Yasue H, Nabeshima T, Araki K, Yamamura K. Truncated CBP protein leads to classical Rubinstein-Taybi syndrome phenotypes in mice: implications for a dominant-negative mechanism. Hum Mol Genet. 1999 Mar; 8(3):387-96.
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Chen YG, Hata A, Lo RS, Wotton D, Shi Y, Pavletich N, Massagué J. Determinants of specificity in TGF-beta signal transduction. Genes Dev. 1998 Jul 15; 12(14):2144-52.
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Hata A, Shi Y, Massagué J. TGF-beta signaling and cancer: structural and functional consequences of mutations in Smads. Mol Med Today. 1998 Jun; 4(6):257-62.
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Hata A, Lagna G, Massagué J, Hemmati-Brivanlou A. Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. Genes Dev. 1998 Jan 15; 12(2):186-97.
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Shi Y, Hata A, Lo RS, Massagué J, Pavletich NP. A structural basis for mutational inactivation of the tumour suppressor Smad4. Nature. 1997 Jul 3; 388(6637):87-93.
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Hata A, Lo RS, Wotton D, Lagna G, Massagué J. Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4. Nature. 1997 Jul 3; 388(6637):82-7.
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Massaous J, Hata A. TGF-beta signalling through the Smad pathway. Trends Cell Biol. 1997 May; 7(5):187-92.
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Kretzschmar M, Liu F, Hata A, Doody J, Massagué J. The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase. Genes Dev. 1997 Apr 15; 11(8):984-95.
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Lagna G, Hata A, Hemmati-Brivanlou A, Massagué J. Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways. Nature. 1996 Oct 31; 383(6603):832-6.
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Liu F, Hata A, Baker JC, Doody J, Cárcamo J, Harland RM, Massagué J. A human Mad protein acting as a BMP-regulated transcriptional activator. Nature. 1996 Jun 13; 381(6583):620-3.
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Hata A, Sabe H, Kurosaki T, Takata M, Hanafusa H. Functional analysis of Csk in signal transduction through the B-cell antigen receptor. Mol Cell Biol. 1994 Nov; 14(11):7306-13.
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Takata M, Sabe H, Hata A, Inazu T, Homma Y, Nukada T, Yamamura H, Kurosaki T. Tyrosine kinases Lyn and Syk regulate B cell receptor-coupled Ca2+ mobilization through distinct pathways. EMBO J. 1994 Mar 15; 13(6):1341-9.
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Hata A, Akita Y, Suzuki K, Ohno S. Functional divergence of protein kinase C (PKC) family members. PKC gamma differs from PKC alpha and -beta II and nPKC epsilon in its competence to mediate-12-O-tetradecanoyl phorbol 13-acetate (TPA)-responsive transcriptional activation through a TPA-response element. J Biol Chem. 1993 Apr 25; 268(12):9122-9.
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Hata A, Ohno S, Suzuki K. Transcriptional activation of the gene for the large subunit of human m-calpain by 12-o-tetradecanoyl-phorbol-13-acetate. FEBS Lett. 1992 Jun 15; 304(2-3):241-4.
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Hata A, Akita Y, Konno Y, Suzuki K, Ohno S. Direct evidence that the kinase activity of protein kinase C is involved in transcriptional activation through a TPA-responsive element. FEBS Lett. 1989 Jul 31; 252(1-2):144-6.
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Hata A, Ohno S, Akita Y, Suzuki K. Tandemly reiterated negative enhancer-like elements regulate transcription of a human gene for the large subunit of calcium-dependent protease. J Biol Chem. 1989 Apr 15; 264(11):6404-11.
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Nakamura Y, Kawaguchi M, Hata A, Watanabe H, Ueki Y, Oribe T, Koba F, Takamuku K. [Combination chemo-endocrine therapy of metastatic and stage IV breast cancer with cyclophosphamide, adriamycin, prednisolone and tamoxifen (CAPT)--with special reference to management of brain and liver metastasis]. Gan To Kagaku Ryoho. 1989 Feb; 16(2):243-50.
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Hata A, Tsuzuki T, Shimada K, Takiguchi M, Mori M, Matsuda I. Structure of the human ornithine transcarbamylase gene. J Biochem. 1988 Feb; 103(2):302-8.
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Hata A, Tsuzuki T, Shimada K, Takiguchi M, Mori M, Matsuda I. Isolation and characterization of the human ornithine transcarbamylase gene: structure of the 5'-end region. J Biochem. 1986 Sep; 100(3):717-25.
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Huang IY, Kimura M, Hata A, Tsunoo H, Yoshida A. Complete amino acid sequence of mouse liver metallothionein-II. J Biochem. 1981 Jun; 89(6):1839-45.
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