Akiko Hata, PhD

SchoolUCSF School of Medicine
DepartmentCardiovascular Research Inst
Address555 Mission Bay Blvd South
San Francisco CA 94158
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    Collapse Biography 
    Collapse Education and Training
    The Rockefeller UniversityPhD1995
    Memorial Sloan-Kettering Cancer CenterPost-doc2000

    Collapse Research 
    Collapse Research Activities and Funding
    Identification of a novel modulator of Pulmonary Artery Hypertension
    NIH/NHLBI R01HL132058Jun 1, 2016 - Mar 31, 2020
    Role: Principal Investigator
    FASEB SRC on TGF-beta Superfamily: Signaling in Development and Disease
    NIH/NCI R13CA196044May 20, 2015 - Apr 30, 2016
    Role: Principal Investigator
    Role of the PDGF signaling pathway in pulmonary artery hypertension
    NIH/NHLBI R01HL116191Aug 15, 2013 - May 31, 2017
    Role: Principal Investigator
    Role of miRNAs in Vascular Physiology
    NIH/NHLBI R01HL093154Jun 1, 2009 - Apr 30, 2014
    Role: Principal Investigator
    Role of BMPRII Mutants in the Pathogenesis of Pulmonary Hypertension
    NIH/NHLBI R01HL082854Jul 1, 2006 - Jun 30, 2011
    Role: Principal Investigator
    Mechanisms of TGFB Signal Transduction
    NIH/NICHD R01HD042149Jul 7, 2003 - May 31, 2010
    Role: Principal Investigator
    Mechanisms of TGFB Signal Transduction
    NIH/NHLBI R01HL108317Apr 1, 2002 - Mar 31, 2015
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Celona B, von Dollen J, Vatsavayai SC, Kashima R, Johnson JR, Tang AA, Hata A, Miller BL, Huang EJ, Krogan NJ, Seeley WW, Black BL. Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106. Elife. 2017 Jan 10; 6. PMID: 28072389.
      View in: PubMed
    2. Hata A, Chen YG. TGF-ß Signaling from Receptors to Smads. Cold Spring Harb Perspect Biol. 2016; 8(9). PMID: 27449815.
      View in: PubMed
    3. Kashima R, Roy S, Ascano M, Martinez-Cerdeno V, Ariza-Torres J, Kim S, Louie J, Lu Y, Leyton P, Bloch KD, Kornberg TB, Hagerman PJ, Hagerman R, Lagna G, Hata A, et al. Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome. Sci Signal. 2016; 9(431):ra58. PMID: 27273096.
      View in: PubMed
    4. Kang H, Hata A. Quantitative Real-Time PCR Analysis of MicroRNAs and Their Precursors Regulated by TGF-ß Signaling. Methods Mol Biol. 2016; 1344:313-23. PMID: 26520134.
      View in: PubMed
    5. Hata A, Kashima R. Dysregulation of microRNA biogenesis machinery in cancer. Crit Rev Biochem Mol Biol. 2016 May-Jun; 51(3):121-34. PMID: 26628006.
      View in: PubMed
    6. Morrell NW, Bloch DB, Ten Dijke P, Goumans MJ, Hata A, Smith J, Yu PB, Bloch KD. Targeting BMP signalling in cardiovascular disease and anaemia. Nat Rev Cardiol. 2016 Feb; 13(2):106-20. PMID: 26461965.
      View in: PubMed
    7. Nazer B, Ghahghaie F, Kashima R, Khokhlova T, Perez C, Crum L, Matula T, Hata A. Therapeutic Ultrasound Promotes Reperfusion and Angiogenesis in a Rat Model of Peripheral Arterial Disease. Circ J. 2015; 79(9):2043-9. PMID: 26062950.
      View in: PubMed
    8. Kang H, Hata A. The role of microRNAs in cell fate determination of mesenchymal stem cells: balancing adipogenesis and osteogenesis. BMB Rep. 2015 Jun; 48(6):319-23. PMID: 25341923; PMCID: PMC4578617.
    9. Cushing L, Costinean S, Xu W, Jiang Z, Madden L, Kuang P, Huang J, Weisman A, Hata A, Croce CM, Lü J. Disruption of miR-29 Leads to Aberrant Differentiation of Smooth Muscle Cells Selectively Associated with Distal Lung Vasculature. PLoS Genet. 2015 May; 11(5):e1005238. PMID: 26020233; PMCID: PMC4447351.
    10. Hata A, Lieberman J. Dysregulation of microRNA biogenesis and gene silencing in cancer. Sci Signal. 2015 Mar 17; 8(368):re3. PMID: 25783160.
      View in: PubMed
    11. Hata A, Kang H. Functions of the bone morphogenetic protein signaling pathway through microRNAs (review). Int J Mol Med. 2015 Mar; 35(3):563-8. PMID: 25571950.
      View in: PubMed
    12. Kim S, Hata A, Kang H. Down-regulation of miR-96 by bone morphogenetic protein signaling is critical for vascular smooth muscle cell phenotype modulation. J Cell Biochem. 2014 May; 115(5):889-95. PMID: 24375867.
      View in: PubMed
    13. Nazer B, Gerstenfeld EP, Hata A, Crum LA, Matula TJ. Cardiovascular applications of therapeutic ultrasound. J Interv Card Electrophysiol. 2014 Apr; 39(3):287-94. PMID: 24297498.
      View in: PubMed
    14. Chang J, Davis-Dusenbery BN, Kashima R, Jiang X, Marathe N, Sessa R, Louie J, Gu W, Lagna G, Hata A. Acetylation of p53 stimulates miRNA processing and determines cell survival following genotoxic stress. EMBO J. 2013 Dec 11; 32(24):3192-205. PMID: 24219989; PMCID: PMC3981142.
    15. Arora P, Wu C, Khan AM, Bloch DB, Davis-Dusenbery BN, Ghorbani A, Spagnolli E, Martinez A, Ryan A, Tainsh LT, Kim S, Rong J, Huan T, Freedman JE, Levy D, Miller KK, Hata A, Del Monte F, Vandenwijngaert S, Swinnen M, Janssens S, Holmes TM, Buys ES, Bloch KD, Newton-Cheh C, Wang TJ. Atrial natriuretic peptide is negatively regulated by microRNA-425. J Clin Invest. 2013 Aug; 123(8):3378-82. PMID: 23867623; PMCID: PMC3726159.
    16. Sessa R, Hata A. Role of microRNAs in lung development and pulmonary diseases. Pulm Circ. 2013 Apr; 3(2):315-28. PMID: 24015331; PMCID: PMC3757825.
    17. Blahna MT, Hata A. Regulation of miRNA biogenesis as an integrated component of growth factor signaling. Curr Opin Cell Biol. 2013 Apr; 25(2):233-40. PMID: 23312066; PMCID: PMC4429755.
    18. Hata A. Functions of microRNAs in cardiovascular biology and disease. Annu Rev Physiol. 2013; 75:69-93. PMID: 23157557.
      View in: PubMed
    19. Akhurst RJ, Hata A. Targeting the TGFß signalling pathway in disease. Nat Rev Drug Discov. 2012 Oct; 11(10):790-811. PMID: 23000686; PMCID: PMC3520610.
    20. Kang H, Louie J, Weisman A, Sheu-Gruttadauria J, Davis-Dusenbery BN, Lagna G, Hata A. Inhibition of microRNA-302 (miR-302) by bone morphogenetic protein 4 (BMP4) facilitates the BMP signaling pathway. J Biol Chem. 2012 Nov 9; 287(46):38656-64. PMID: 22988237; PMCID: PMC3493910.
    21. Wang D, Prakash J, Nguyen P, Davis-Dusenbery BN, Hill NS, Layne MD, Hata A, Lagna G. Bone morphogenetic protein signaling in vascular disease: anti-inflammatory action through myocardin-related transcription factor A. J Biol Chem. 2012 Aug 10; 287(33):28067-77. PMID: 22718766; PMCID: PMC3431673.
    22. Kang H, Hata A. MicroRNA regulation of smooth muscle gene expression and phenotype. Curr Opin Hematol. 2012 May; 19(3):224-31. PMID: 22406821.
      View in: PubMed
    23. Hata A, Brivanlou AH. A taste of TGFß in Tuscany. Development. 2012 Feb; 139(3):449-53. PMID: 22223676.
      View in: PubMed
    24. Blahna MT, Hata A. Smad-mediated regulation of microRNA biosynthesis. FEBS Lett. 2012 Jul 4; 586(14):1906-12. PMID: 22306316; PMCID: PMC4429768.
    25. Kang H, Davis-Dusenbery BN, Nguyen PH, Lal A, Lieberman J, Van Aelst L, Lagna G, Hata A. Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins. J Biol Chem. 2012 Feb 3; 287(6):3976-86. PMID: 22158624; PMCID: PMC3281737.
    26. McDonald RA, Hata A, MacLean MR, Morrell NW, Baker AH. MicroRNA and vascular remodelling in acute vascular injury and pulmonary vascular remodelling. Cardiovasc Res. 2012 Mar 15; 93(4):594-604. PMID: 22065733; PMCID: PMC3410429.
    27. Davis-Dusenbery BN, Wu C, Hata A. Micromanaging vascular smooth muscle cell differentiation and phenotypic modulation. Arterioscler Thromb Vasc Biol. 2011 Nov; 31(11):2370-7. PMID: 22011749; PMCID: PMC4429757.
    28. Wu C, So J, Davis-Dusenbery BN, Qi HH, Bloch DB, Shi Y, Lagna G, Hata A. Hypoxia potentiates microRNA-mediated gene silencing through posttranslational modification of Argonaute2. Mol Cell Biol. 2011 Dec; 31(23):4760-74. PMID: 21969601; PMCID: PMC3232924.
    29. Davis-Dusenbery BN, Chan MC, Reno KE, Weisman AS, Layne MD, Lagna G, Hata A. down-regulation of Kruppel-like factor-4 (KLF4) by microRNA-143/145 is critical for modulation of vascular smooth muscle cell phenotype by transforming growth factor-beta and bone morphogenetic protein 4. J Biol Chem. 2011 Aug 12; 286(32):28097-110. PMID: 21673106; PMCID: PMC3151055.
    30. Hata A, Davis BN. Regulation of pri-miRNA Processing Through Smads. Adv Exp Med Biol. 2011; 700:15-27. PMID: 21755469.
      View in: PubMed
    31. Davis-Dusenbery BN, Hata A. Smad-mediated miRNA processing: a critical role for a conserved RNA sequence. RNA Biol. 2011 Jan-Feb; 8(1):71-6. PMID: 21289485; PMCID: PMC3230544.
    32. Chan MC, Weisman AS, Kang H, Nguyen PH, Hickman T, Mecker SV, Hill NS, Lagna G, Hata A. The amiloride derivative phenamil attenuates pulmonary vascular remodeling by activating NFAT and the bone morphogenetic protein signaling pathway. Mol Cell Biol. 2011 Feb; 31(3):517-30. PMID: 21135135; PMCID: PMC3028626.
    33. Davis-Dusenbery BN, Hata A. MicroRNA in Cancer: The Involvement of Aberrant MicroRNA Biogenesis Regulatory Pathways. Genes Cancer. 2010 Nov; 1(11):1100-14. PMID: 21533017; PMCID: PMC3083114.
    34. Davis-Dusenbery BN, Hata A. Mechanisms of control of microRNA biogenesis. J Biochem. 2010 Oct; 148(4):381-92. PMID: 20833630; PMCID: PMC2981492.
    35. Davis BN, Hilyard AC, Nguyen PH, Lagna G, Hata A. Smad proteins bind a conserved RNA sequence to promote microRNA maturation by Drosha. Mol Cell. 2010 Aug 13; 39(3):373-84. PMID: 20705240; PMCID: PMC2921543.
    36. Hata A, Davis BN. Regulation of pri-miRNA processing through Smads. Adv Exp Med Biol. 2010; 700:15-27. PMID: 21627026.
      View in: PubMed
    37. Chan MC, Hilyard AC, Wu C, Davis BN, Hill NS, Lal A, Lieberman J, Lagna G, Hata A. Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression. EMBO J. 2010 Feb 3; 29(3):559-73. PMID: 20019669; PMCID: PMC2830697.
    38. Hata A, Davis BN. Control of microRNA biogenesis by TGFbeta signaling pathway-A novel role of Smads in the nucleus. Cytokine Growth Factor Rev. 2009 Oct-Dec; 20(5-6):517-21. PMID: 19892582; PMCID: PMC2787811.
    39. Davis BN, Hata A. Regulation of MicroRNA Biogenesis: A miRiad of mechanisms. Cell Commun Signal. 2009; 7:18. PMID: 19664273; PMCID: PMC3224893.
    40. Huang S, Laoukili J, Epping MT, Koster J, Hölzel M, Westerman BA, Nijkamp W, Hata A, Asgharzadeh S, Seeger RC, Versteeg R, Beijersbergen RL, Bernards R. ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome. Cancer Cell. 2009 Apr 7; 15(4):328-40. PMID: 19345331; PMCID: PMC2693316.
    41. Neuman NA, Ma S, Schnitzler GR, Zhu Y, Lagna G, Hata A. The four-and-a-half LIM domain protein 2 regulates vascular smooth muscle phenotype and vascular tone. J Biol Chem. 2009 May 8; 284(19):13202-12. PMID: 19265191; PMCID: PMC2676052.
    42. Davis BN, Hilyard AC, Nguyen PH, Lagna G, Hata A. Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype. J Biol Chem. 2009 Feb 6; 284(6):3728-38. PMID: 19088079; PMCID: PMC2635044.
    43. Davis BN, Hilyard AC, Lagna G, Hata A. SMAD proteins control DROSHA-mediated microRNA maturation. Nature. 2008 Jul 3; 454(7200):56-61. PMID: 18548003; PMCID: PMC2653422.
    44. Lagna G, Ku MM, Nguyen PH, Neuman NA, Davis BN, Hata A. Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors. J Biol Chem. 2007 Dec 21; 282(51):37244-55. PMID: 17947237; PMCID: PMC3405982.
    45. Chan MC, Nguyen PH, Davis BN, Ohoka N, Hayashi H, Du K, Lagna G, Hata A. A novel regulatory mechanism of the bone morphogenetic protein (BMP) signaling pathway involving the carboxyl-terminal tail domain of BMP type II receptor. Mol Cell Biol. 2007 Aug; 27(16):5776-89. PMID: 17576816; PMCID: PMC1952124.
    46. Lagna G, Nguyen PH, Ni W, Hata A. BMP-dependent activation of caspase-9 and caspase-8 mediates apoptosis in pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2006 Nov; 291(5):L1059-67. PMID: 17030903.
      View in: PubMed
    47. Ku M, Howard S, Ni W, Lagna G, Hata A. OAZ regulates bone morphogenetic protein signaling through Smad6 activation. J Biol Chem. 2006 Feb 24; 281(8):5277-87. PMID: 16373339.
      View in: PubMed
    48. Ku M, Sokol SY, Wu J, Tussie-Luna MI, Roy AL, Hata A. Positive and negative regulation of the transforming growth factor beta/activin target gene goosecoid by the TFII-I family of transcription factors. Mol Cell Biol. 2005 Aug; 25(16):7144-57. PMID: 16055724; PMCID: PMC1190264.
    49. Seki K, Hata A. Indian hedgehog gene is a target of the bone morphogenetic protein signaling pathway. J Biol Chem. 2004 Apr 30; 279(18):18544-9. PMID: 14981086.
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    50. Ku MC, Stewart S, Hata A. Poly(ADP-ribose) polymerase 1 interacts with OAZ and regulates BMP-target genes. Biochem Biophys Res Commun. 2003 Nov 21; 311(3):702-7. PMID: 14623329.
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    51. Bond HM, Mesuraca M, Carbone E, Bonelli P, Agosti V, Amodio N, De Rosa G, Di Nicola M, Gianni AM, Moore MA, Hata A, Grieco M, Morrone G, Venuta S. Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells. Blood. 2004 Mar 15; 103(6):2062-70. PMID: 14630787.
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    52. Seki K, Fujimori T, Savagner P, Hata A, Aikawa T, Ogata N, Nabeshima Y, Kaechoong L. Mouse Snail family transcription repressors regulate chondrocyte, extracellular matrix, type II collagen, and aggrecan. J Biol Chem. 2003 Oct 24; 278(43):41862-70. PMID: 12917416; PMCID: PMC2253659.
    53. Arima T, Drewell RA, Arney KL, Inoue J, Makita Y, Hata A, Oshimura M, Wake N, Surani MA. A conserved imprinting control region at the HYMAI/ZAC domain is implicated in transient neonatal diabetes mellitus. Hum Mol Genet. 2001 Jul 1; 10(14):1475-83. PMID: 11448939.
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    54. Hata A. TGFbeta signaling and cancer. Exp Cell Res. 2001 Mar 10; 264(1):111-6. PMID: 11237527.
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    55. Hata A, Seoane J, Lagna G, Montalvo E, Hemmati-Brivanlou A, Massagué J. OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways. Cell. 2000 Jan 21; 100(2):229-40. PMID: 10660046.
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    56. Oike Y, Hata A, Mamiya T, Kaname T, Noda Y, Suzuki M, Yasue H, Nabeshima T, Araki K, Yamamura K. Truncated CBP protein leads to classical Rubinstein-Taybi syndrome phenotypes in mice: implications for a dominant-negative mechanism. Hum Mol Genet. 1999 Mar; 8(3):387-96. PMID: 9949198.
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    57. Chen YG, Hata A, Lo RS, Wotton D, Shi Y, Pavletich N, Massagué J. Determinants of specificity in TGF-beta signal transduction. Genes Dev. 1998 Jul 15; 12(14):2144-52. PMID: 9679059; PMCID: PMC317013.
    58. Hata A, Shi Y, Massagué J. TGF-beta signaling and cancer: structural and functional consequences of mutations in Smads. Mol Med Today. 1998 Jun; 4(6):257-62. PMID: 9679244.
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    59. Hata A, Lagna G, Massagué J, Hemmati-Brivanlou A. Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. Genes Dev. 1998 Jan 15; 12(2):186-97. PMID: 9436979; PMCID: PMC316444.
    60. Shi Y, Hata A, Lo RS, Massagué J, Pavletich NP. A structural basis for mutational inactivation of the tumour suppressor Smad4. Nature. 1997 Jul 3; 388(6637):87-93. PMID: 9214508.
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    61. Hata A, Lo RS, Wotton D, Lagna G, Massagué J. Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4. Nature. 1997 Jul 3; 388(6637):82-7. PMID: 9214507.
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    62. Kretzschmar M, Liu F, Hata A, Doody J, Massagué J. The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase. Genes Dev. 1997 Apr 15; 11(8):984-95. PMID: 9136927.
      View in: PubMed
    63. Lagna G, Hata A, Hemmati-Brivanlou A, Massagué J. Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways. Nature. 1996 Oct 31; 383(6603):832-6. PMID: 8893010.
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    64. Liu F, Hata A, Baker JC, Doody J, Cárcamo J, Harland RM, Massagué J. A human Mad protein acting as a BMP-regulated transcriptional activator. Nature. 1996 Jun 13; 381(6583):620-3. PMID: 8637600.
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    65. Hata A, Sabe H, Kurosaki T, Takata M, Hanafusa H. Functional analysis of Csk in signal transduction through the B-cell antigen receptor. Mol Cell Biol. 1994 Nov; 14(11):7306-13. PMID: 7935444; PMCID: PMC359265.
    66. Takata M, Sabe H, Hata A, Inazu T, Homma Y, Nukada T, Yamamura H, Kurosaki T. Tyrosine kinases Lyn and Syk regulate B cell receptor-coupled Ca2+ mobilization through distinct pathways. EMBO J. 1994 Mar 15; 13(6):1341-9. PMID: 8137818; PMCID: PMC394950.
    67. Hata A, Akita Y, Suzuki K, Ohno S. Functional divergence of protein kinase C (PKC) family members. PKC gamma differs from PKC alpha and -beta II and nPKC epsilon in its competence to mediate-12-O-tetradecanoyl phorbol 13-acetate (TPA)-responsive transcriptional activation through a TPA-response element. J Biol Chem. 1993 Apr 25; 268(12):9122-9. PMID: 8473351.
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    68. Hata A, Akita Y, Konno Y, Suzuki K, Ohno S. Direct evidence that the kinase activity of protein kinase C is involved in transcriptional activation through a TPA-responsive element. FEBS Lett. 1989 Jul 31; 252(1-2):144-6. PMID: 2759229.
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    69. Hata A, Ohno S, Akita Y, Suzuki K. Tandemly reiterated negative enhancer-like elements regulate transcription of a human gene for the large subunit of calcium-dependent protease. J Biol Chem. 1989 Apr 15; 264(11):6404-11. PMID: 2539381.
      View in: PubMed
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