Alice Chan, MD, PhD

Title(s)Associate Professor, Pediatrics
SchoolSchool of Medicine
ORCID ORCID Icon0000-0003-1466-7044 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Texas Southwestern Medical SchoolMD, PhD2008
    University of California, San FranciscoResidency 2011Pediatrics
    University of California, San FranciscoFellowship2016Allergy/Immunology
    University of California, San FranciscoFellowship2016Pediatric Rheumatology
    University of California, San Francisco, CA2019Diversity, Equity, and Inclusion Champion Training

    Collapse Overview 
    Collapse Overview
    I'm a pediatric immunologist and rheumatologist dedicated to improving our understanding of immune regulation to advance care for patients with immune system disorders. My clinical practice is focused on diagnosing and managing patients with complex or unknown immune system disorders. My research area is focused on studying genes that regulate the immune system. We utilize CRISPR/Cas9 to generate mouse models harboring human mutations to help elucidate the molecular mechanism driving disease.

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance. J Exp Med. 2021 08 02; 218(8). Warshauer JT, Belk JA, Chan AY, Wang J, Gupta AR, Shi Q, Skartsis N, Peng Y, Phipps JD, Acenas D, Smith JA, Tamaki SJ, Tang Q, Gardner JM, Satpathy AT, Anderson MS. PMID: 34115115; PMCID: PMC8203485.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    2. The autoimmune targets in IPEX are dominated by gut epithelial proteins. J Allergy Clin Immunol. 2019 07; 144(1):327-330.e8. Eriksson D, Bacchetta R, Gunnarsson HI, Chan A, Barzaghi F, Ehl S, Hallgren Å, van Gool F, Sardh F, Lundqvist C, Laakso SM, Rönnblom A, Ekwall O, Mäkitie O, Bensing S, Husebye ES, Anderson M, Kämpe O, Landegren N. PMID: 31027649.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    3. A large CRISPR-induced bystander mutation causes immune dysregulation. Commun Biol. 2019; 2:70. Simeonov DR, Brandt AJ, Chan AY, Cortez JT, Li Z, Woo JM, Lee Y, Carvalho CMB, Indart AC, Roth TL, Zou J, May AP, Lupski JR, Anderson MS, Buaas FW, Rokhsar DS, Marson A. PMID: 30793048; PMCID: PMC6379443.
      View in: PubMed   Mentions: 11  Translation:AnimalsCells
    4. Author Correction: Discovery of stimulation-responsive immune enhancers with CRISPR activation. Nature. 2018 07; 559(7715):E13. Simeonov DR, Gowen BG, Boontanrart M, Roth TL, Gagnon JD, Mumbach MR, Satpathy AT, Lee Y, Bray NL, Chan AY, Lituiev DS, Nguyen ML, Gate RE, Subramaniam M, Li Z, Woo JM, Mitros T, Ray GJ, Curie GL, Naddaf N, Chu JS, Ma H, Boyer E, Van Gool F, Huang H, Liu R, Tobin VR, Schumann K, Daly MJ, Farh KK, Ansel KM, Ye CJ, Greenleaf WJ, Anderson MS, Bluestone JA, Chang HY, Corn JE, Marson A. PMID: 29899441.
      View in: PubMed   Mentions:    Fields:    
    5. Analysis of pulmonary features and treatment approaches in the COPA syndrome. ERJ Open Res. 2018 Apr; 4(2). Tsui JL, Estrada OA, Deng Z, Wang KM, Law CS, Elicker BM, Jones KD, Dell SD, Gudmundsson G, Hansdottir S, Helfgott SM, Volpi S, Gattorno M, Waterfield MR, Chan AY, Chung SA, Ley B, Shum AK. PMID: 29977900; PMCID: PMC6019741.
      View in: PubMed   Mentions: 27  
    6. Discovery of stimulation-responsive immune enhancers with CRISPR activation. Nature. 2017 09 07; 549(7670):111-115. Simeonov DR, Gowen BG, Boontanrart M, Roth TL, Gagnon JD, Mumbach MR, Satpathy AT, Lee Y, Bray NL, Chan AY, Lituiev DS, Nguyen ML, Gate RE, Subramaniam M, Li Z, Woo JM, Mitros T, Ray GJ, Curie GL, Naddaf N, Chu JS, Ma H, Boyer E, Van Gool F, Huang H, Liu R, Tobin VR, Schumann K, Daly MJ, Farh KK, Ansel KM, Ye CJ, Greenleaf WJ, Anderson MS, Bluestone JA, Chang HY, Corn JE, Marson A. PMID: 28854172; PMCID: PMC5675716.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansAnimalsCells
    7. Exome Sequencing Reveals Mutations in AIRE as a Cause of Isolated Hypoparathyroidism. J Clin Endocrinol Metab. 2017 05 01; 102(5):1726-1733. Li D, Streeten EA, Chan A, Lwin W, Tian L, Pellegrino da Silva R, Kim CE, Anderson MS, Hakonarson H, Levine MA. PMID: 28323927; PMCID: PMC5443324.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    8. Primary immunodeficiency diseases: Genomic approaches delineate heterogeneous Mendelian disorders. J Allergy Clin Immunol. 2017 01; 139(1):232-245. Stray-Pedersen A, Sorte HS, Samarakoon P, Gambin T, Chinn IK, Coban Akdemir ZH, Erichsen HC, Forbes LR, Gu S, Yuan B, Jhangiani SN, Muzny DM, Rødningen OK, Sheng Y, Nicholas SK, Noroski LM, Seeborg FO, Davis CM, Canter DL, Mace EM, Vece TJ, Allen CE, Abhyankar HA, Boone PM, Beck CR, Wiszniewski W, Fevang B, Aukrust P, Tjønnfjord GE, Gedde-Dahl T, Hjorth-Hansen H, Dybedal I, Nordøy I, Jørgensen SF, Abrahamsen TG, Øverland T, Bechensteen AG, Skogen V, Osnes LTN, Kulseth MA, Prescott TE, Rustad CF, Heimdal KR, Belmont JW, Rider NL, Chinen J, Cao TN, Smith EA, Caldirola MS, Bezrodnik L, Lugo Reyes SO, Espinosa Rosales FJ, Guerrero-Cursaru ND, Pedroza LA, Poli CM, Franco JL, Trujillo Vargas CM, Aldave Becerra JC, Wright N, Issekutz TB, Issekutz AC, Abbott J, Caldwell JW, Bayer DK, Chan AY, Aiuti A, Cancrini C, Holmberg E, West C, Burstedt M, Karaca E, Yesil G, Artac H, Bayram Y, Atik MM, Eldomery MK, Ehlayel MS, Jolles S, Flatø B, Bertuch AA, Hanson IC, Zhang VW, Wong LJ, Hu J, Walkiewicz M, Yang Y, Eng CM, Boerwinkle E, Gibbs RA, Shearer WT, Lyle R, Orange JS, Lupski JR. PMID: 27577878; PMCID: PMC5222743.
      View in: PubMed   Mentions: 120     Fields:    Translation:Humans
    9. A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70. J Exp Med. 2016 Feb 08; 213(2):155-65. Chan AY, Punwani D, Kadlecek TA, Cowan MJ, Olson JL, Mathes EF, Sunderam U, Fu SM, Srinivasan R, Kuriyan J, Brenner SE, Weiss A, Puck JM. PMID: 26783323; PMCID: PMC4749924.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    10. Central tolerance to self revealed by the autoimmune regulator. Ann N Y Acad Sci. 2015 Nov; 1356:80-9. Chan AY, Anderson MS. PMID: 26579596; PMCID: PMC4654700.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    11. B cell-intrinsic CD84 and Ly108 maintain germinal center B cell tolerance. J Immunol. 2015 May 01; 194(9):4130-43. Wong EB, Soni C, Chan AY, Domeier PP, Abraham T, Limaye N, Khan TN, Elias MJ, Chodisetti SB, Wakeland EK, Rahman ZS. PMID: 25801429; PMCID: PMC4402266.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    12. Combined immunodeficiency due to MALT1 mutations, treated by hematopoietic cell transplantation. J Clin Immunol. 2015 Feb; 35(2):135-46. Punwani D, Wang H, Chan AY, Cowan MJ, Mallott J, Sunderam U, Mollenauer M, Srinivasan R, Brenner SE, Mulder A, Claas FH, Weiss A, Puck JM. PMID: 25627829; PMCID: PMC4352191.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    13. Treatment of juvenile idiopathic arthritis. Pediatr Ann. 2012 Nov; 41(11). Chan AY, Milojevic D. PMID: 23814934.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Early vs. delayed diagnosis of severe combined immunodeficiency: a family perspective survey. Clin Immunol. 2011 Jan; 138(1):3-8. Chan A, Scalchunes C, Boyle M, Puck JM. PMID: 21035402; PMCID: PMC3022101.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansPHPublic Health
    15. Antigen-specific responses and ANA production in B6.Sle1b mice: a role for SAP. J Autoimmun. 2008 Dec; 31(4):345-53. Jennings P, Chan A, Schwartzberg P, Wakeland EK, Yuan D. PMID: 18845419; PMCID: PMC2877280.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    16. The role of SAP and the SLAM family in autoimmunity. Curr Opin Immunol. 2006 Dec; 18(6):656-64. Chan AY, Westcott JM, Mooney JM, Wakeland EK, Schatzle JD. PMID: 17011767.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    17. Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus. Immunity. 2004 Dec; 21(6):769-80. Wandstrat AE, Nguyen C, Limaye N, Chan AY, Subramanian S, Tian XH, Yim YS, Pertsemlidis A, Garner HR, Morel L, Wakeland EK. PMID: 15589166.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansAnimalsCells
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