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Qizhi Tang, PhD

Address513 Parnassus Ave
San Francisco CA 94143
Phone415-476-1739
EmailQizhi.Tang@ucsf.edu
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral Studies2002Graduate Division
    Univeristy of ChicagoPostdoctoral Studies2000Immunology
    University of Illinios, ChicagoPhD1996Microbiology and Immunology
    University of South AlabamaGraduate School1991Microbiology and Immunology
    Perkin Union Medical CollegeMedical School1989Medcine

    Collapse Overview 
    Collapse Overview
    The Tang lab focuses on translating knowledge on mechanisms of immune tolerance into novel therapeutics for treating autoimmune diabetes and preventing transplant rejection. Currently, two major areas of work are on therapeutic application of regulatory T cell therapy in type 1 diabetes and transplantation and immune modulation to enable immune suppression-free transplant of stem-cell-derived beta cells for treatment of type 1 diabetes.

    Regulatory T cells are a small population of white blood cells that are essential for preventing tissue damages caused by over activation of the immune system. The Tang lab has shown that infusion of regulatory T cells in animal models can reverse type 1 diabetes, a disease caused by immune destruction of insulin-producing cells in the pancreatic islets. Similarly, regulatory T cell therapy can prevent rejection of transplanted organs in animal models. A joint team of researchers from the Tang and Bluestone labs is currently conducting 6 clinical trials evaluating the safety and efficacy of regulatory T cell therapy in patients. In the mean time, we are developing next generation regulatory T cell therapies in preclinical models to improve the safety and efficacy of the therapy.

    In patients with chronic type 1 diabetes, transplanting of stem-cell-derived beta cells can potentially cure the disease, but patients have to commit to life-long immunosuppression to prevent rejection of the transplanted cells from rejection by the immune system. The Tang lab is currently investigating approaches to shield the transplanted cells from the immune systems using novel biomaterials developed in the Desai and Roy labs at UCSF. We are also applying genome-editing technologies to immunoengineer stem cells to evade immune rejection.


    Collapse Research 
    Collapse Research Activities and Funding
    Multiplex in situ gene expression and phenotypical profiling of inflamed tissues
    NIH/NIAID U24AI118675Jun 26, 2015 - May 31, 2020
    Role: Co-Principal Investigator
    Donor-Alloantigen-Reactive Regulatory T Cell Therapy in Liver Transplantation
    NIH/NIAID U01AI110658Jun 1, 2014 - May 31, 2019
    Role: Co-Principal Investigator
    "Donor-Specific Regulatory T Cell Therapy in Liver Transplantation"
    NIH/NIAID R34AI095135Apr 1, 2012 - Mar 31, 2014
    Role: Co-Principal Investigator
    "Regulatory 'T'Cell Control of Autoimmune Diabetes".
    NIH/NIDDK R01DK085231Mar 15, 2010 - Feb 28, 2015
    Role: Principal Investigator
    BD FACS ARIA II CELL SORTER
    NIH/NCRR S10RR027088Feb 1, 2010 - Jan 31, 2011
    Role: Principal Investigator
    Visualizing regulatory T cell control of autoimmunity
    NIH/NIAID R21AI066097Jul 1, 2005 - Jun 30, 2008
    Role: Principal Investigator
    Diabetes Research Center
    NIH/NIDDK P30DK063720Sep 1, 2002 - Mar 31, 2020
    Role: Co-Investigator
    T CELL ACTIVATION AND ANERGY INDUCTION BY ANTI-CD3
    NIH/NIAID F32AI010360Feb 1, 2000
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Clinical Trials
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Faleo G, Russ HA, Wisel S, Parent AV, Nguyen V, Nair GG, Freise JE, Villanueva KE, Szot GL, Hebrok M, Tang Q. Mitigating Ischemic Injury of Stem Cell-Derived Insulin-Producing Cells after Transplant. Stem Cell Reports. 2017 Sep 12; 9(3):807-819. PMID: 28803916.
      View in: PubMed
    2. Chang R, Faleo G, Russ HA, Parent AV, Elledge SK, Bernards DA, Allen JL, Villanueva K, Hebrok M, Tang Q, Desai TA. Nanoporous Immunoprotective Device for Stem-Cell-Derived ß-Cell Replacement Therapy. ACS Nano. 2017 Aug 22; 11(8):7747-7757. PMID: 28763191.
      View in: PubMed
    3. Chandran S, Tang Q, Sarwal M, Laszik ZG, Putnam AL, Lee K, Leung J, Nguyen V, Sigdel T, Tavares EC, Yang JYC, Hellerstein M, Fitch M, Bluestone JA, Vincenti F. Polyclonal Regulatory T Cell Therapy for Control of Inflammation in Kidney Transplants. Am J Transplant. 2017 Jul 04. PMID: 28675676.
      View in: PubMed
    4. Tang Q, Vincenti F. Transplant trials with Tregs: perils and promises. J Clin Invest. 2017 Jun 30; 127(7):2505-2512. PMID: 28665300.
      View in: PubMed
    5. Klementowicz JE, Mahne AE, Spence A, Nguyen V, Satpathy AT, Murphy KM, Tang Q. Cutting Edge: Origins, Recruitment, and Regulation of CD11c+ Cells in Inflamed Islets of Autoimmune Diabetes Mice. J Immunol. 2017 Jul 01; 199(1):27-32. PMID: 28550204.
      View in: PubMed
    6. Ferreira LM, Tang Q. Generating Antigen-Specific Regulatory T Cells in the Fast Lane. Am J Transplant. 2017 Apr; 17(4):851-853. PMID: 28102024.
      View in: PubMed
    7. Michels AW, Landry LG, McDaniel KA, Yu L, Campbell-Thompson M, Kwok WW, Jones KL, Gottlieb PA, Kappler JW, Tang Q, Roep BO, Atkinson MA, Mathews CE, Nakayama M. Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes. Diabetes. 2017 Mar; 66(3):722-734. PMID: 27920090.
      View in: PubMed
    8. Furukawa A, Wisel SA, Tang Q. Impact of Immune-Modulatory Drugs on Regulatory T Cell. Transplantation. 2016 Nov; 100(11):2288-2300. PMID: 27490409.
      View in: PubMed
    9. Spence A, Tang Q. Restoring Regulatory T Cells in Type 1 Diabetes. Curr Diab Rep. 2016 Nov; 16(11):110. PMID: 27664043.
      View in: PubMed
    10. Greenland JR, Wong CM, Ahuja R, Wang AS, Uchida C, Golden JA, Hays SR, Leard LE, Rajalingam R, Singer JP, Kukreja J, Wolters PJ, Caughey GH, Tang Q. Donor-Reactive Regulatory T Cell Frequency Increases During Acute Cellular Rejection of Lung Allografts. Transplantation. 2016 Oct; 100(10):2090-8. PMID: 27077597.
      View in: PubMed
    11. Higdon LE, Lee K, Tang Q, Maltzman JS. Virtual Global Transplant Laboratory Standard Operating Procedures for Blood Collection, PBMC Isolation, and Storage. Transplant Direct. 2016 Sep; 2(9):e101. PMID: 27795993.
      View in: PubMed
    12. Faleo G, Lee K, Nguyen V, Tang Q. Assessment of Immune Isolation of Allogeneic Mouse Pancreatic Progenitor Cells by a Macroencapsulation Device. Transplantation. 2016 Jun; 100(6):1211-8. PMID: 26982952; PMCID: PMC4874841 [Available on 06/01/17].
    13. Frascoli M, Jeanty C, Fleck S, Moradi PW, Keating S, Mattis AN, Tang Q, MacKenzie TC. Heightened Immune Activation in Fetuses with Gastroschisis May Be Blocked by Targeting IL-5. J Immunol. 2016 Jun 15; 196(12):4957-66. PMID: 27183609; PMCID: PMC4977025 [Available on 06/15/17].
    14. Song S, Faleo G, Yeung R, Kant R, Posselt AM, Desai TA, Tang Q, Roy S. Silicon nanopore membrane (SNM) for islet encapsulation and immunoisolation under convective transport. Sci Rep. 2016 Mar 24; 6:23679. PMID: 27009429; PMCID: PMC4806308.
    15. Tang Q, Desai TA. Approaching a cure for type 1 diabetes. Nat Med. 2016 Mar; 22(3):236-7. PMID: 26937617.
      View in: PubMed
    16. Bluestone JA, Buckner JH, Fitch M, Gitelman SE, Gupta S, Hellerstein MK, Herold KC, Lares A, Lee MR, Li K, Liu W, Long SA, Masiello LM, Nguyen V, Putnam AL, Rieck M, Sayre PH, Tang Q. Type 1 diabetes immunotherapy using polyclonal regulatory T cells. Sci Transl Med. 2015 Nov 25; 7(315):315ra189. PMID: 26606968; PMCID: PMC4729454 [Available on 11/25/16].
    17. Zhang M, Tang Q. Manipulating IL-2 and IL-2R in autoimmune diseases and transplantation. Immunotherapy. 2015; 7(12):1231-4. PMID: 26601714.
      View in: PubMed
    18. Spence A, Klementowicz JE, Bluestone JA, Tang Q. Targeting Treg signaling for the treatment of autoimmune diseases. Curr Opin Immunol. 2015 Dec; 37:11-20. PMID: 26432763.
      View in: PubMed
    19. Tang Q. Therapeutic window of interleukin-2 for autoimmune diseases. Diabetes. 2015 Jun; 64(6):1912-3. PMID: 25999537; PMCID: PMC4439560.
    20. Nyitray CE, Chang R, Faleo G, Lance KD, Bernards DA, Tang Q, Desai TA. Polycaprolactone Thin-Film Micro- and Nanoporous Cell-Encapsulation Devices. ACS Nano. 2015 Jun 23; 9(6):5675-82. PMID: 25950860; PMCID: PMC4628825.
    21. Bluestone JA, Tang Q. Immunotherapy: making the case for precision medicine. Sci Transl Med. 2015 Mar 25; 7(280):280ed3. PMID: 25810308.
      View in: PubMed
    22. Wegorzewska M, Le T, Tang Q, MacKenzie TC. Increased maternal T cell microchimerism in the allogeneic fetus during LPS-induced preterm labor in mice. Chimerism. 2014; 5(3-4):68-74. PMID: 25779065.
      View in: PubMed
    23. Mahne AE, Klementowicz JE, Chou A, Nguyen V, Tang Q. Therapeutic regulatory T cells subvert effector T cell function in inflamed islets to halt autoimmune diabetes. J Immunol. 2015 Apr 01; 194(7):3147-55. PMID: 25732730; PMCID: PMC4369402.
    24. Lindsay RS, Corbin K, Mahne A, Levitt BE, Gebert MJ, Wigton EJ, Bradley BJ, Haskins K, Jacobelli J, Tang Q, Krummel MF, Friedman RS. Antigen recognition in the islets changes with progression of autoimmune islet infiltration. J Immunol. 2015 Jan 15; 194(2):522-30. PMID: 25505281; PMCID: PMC4282963.
    25. Tang Q, Kang SM. Interpretation of transplant biopsies and immune responses following Treg cell therapy. Curr Opin Organ Transplant. 2014 Dec; 19(6):616-20. PMID: 25313874; PMCID: PMC4825683.
    26. Tang Q. Pharmacokinetics of therapeutic Tregs. Am J Transplant. 2014 Dec; 14(12):2679-80. PMID: 25358900.
      View in: PubMed
    27. Lee RH, Roll G, Nguyen V, Willenbring H, Tang Q, Kang SM, Stock PG. Failure to achieve normal metabolic response in non-obese diabetic mice and streptozotocin-induced diabetic mice after transplantation of primary murine hepatocytes electroporated with the human proinsulin gene (p3MTChins). Transplant Proc. 2014 Jul-Aug; 46(6):2002-6. PMID: 25131094.
      View in: PubMed
    28. Wegorzewska M, Nijagal A, Wong CM, Le T, Lescano N, Tang Q, MacKenzie TC. Fetal intervention increases maternal T cell awareness of the foreign conceptus and can lead to immune-mediated fetal demise. J Immunol. 2014 Feb 15; 192(4):1938-45. PMID: 24415782; PMCID: PMC4268439.
    29. Lee K, Nguyen V, Lee KM, Kang SM, Tang Q. Attenuation of donor-reactive T cells allows effective control of allograft rejection using regulatory T cell therapy. Am J Transplant. 2014 Jan; 14(1):27-38. PMID: 24354870.
      View in: PubMed
    30. Tang Q, Bluestone JA. Regulatory T-cell therapy in transplantation: moving to the clinic. Cold Spring Harb Perspect Med. 2013 Nov 01; 3(11). PMID: 24186492; PMCID: PMC3808774.
    31. Putnam AL, Safinia N, Medvec A, Laszkowska M, Wray M, Mintz MA, Trotta E, Szot GL, Liu W, Lares A, Lee K, Laing A, Lechler RI, Riley JL, Bluestone JA, Lombardi G, Tang Q. Clinical grade manufacturing of human alloantigen-reactive regulatory T cells for use in transplantation. Am J Transplant. 2013 Nov; 13(11):3010-20. PMID: 24102808; PMCID: PMC4161737.
    32. Nijagal A, Derderian C, Le T, Jarvis E, Nguyen L, Tang Q, Mackenzie TC. Direct and indirect antigen presentation lead to deletion of donor-specific T cells after in utero hematopoietic cell transplantation in mice. Blood. 2013 May 30; 121(22):4595-602. PMID: 23610372; PMCID: PMC3668492.
    33. Tang Q, Leung J, Melli K, Lay K, Chuu EL, Liu W, Bluestone JA, Kang SM, Peddi VR, Vincenti F. Altered balance between effector T cells and FOXP3+ HELIOS+ regulatory T cells after thymoglobulin induction in kidney transplant recipients. Transpl Int. 2012 Dec; 25(12):1257-67. PMID: 22994802.
      View in: PubMed
    34. Lerner AG, Upton JP, Praveen PV, Ghosh R, Nakagawa Y, Igbaria A, Shen S, Nguyen V, Backes BJ, Heiman M, Heintz N, Greengard P, Hui S, Tang Q, Trusina A, Oakes SA, Papa FR. IRE1a induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metab. 2012 Aug 08; 16(2):250-64. PMID: 22883233; PMCID: PMC4014071.
    35. Tang Q, Lee K. Regulatory T-cell therapy for transplantation: how many cells do we need? Curr Opin Organ Transplant. 2012 Aug; 17(4):349-54. PMID: 22790069.
      View in: PubMed
    36. Nijagal A, Fleck S, Hills NK, Feng S, Tang Q, Kang SM, Rosenthal P, MacKenzie TC. Decreased risk of graft failure with maternal liver transplantation in patients with biliary atresia. Am J Transplant. 2012 Feb; 12(2):409-19. PMID: 22221561.
      View in: PubMed
    37. Tang Q, Bluestone JA, Kang SM. CD4(+)Foxp3(+) regulatory T cell therapy in transplantation. J Mol Cell Biol. 2012 Feb; 4(1):11-21. PMID: 22170955; PMCID: PMC3695644.
    38. Scapini P, Lamagna C, Hu Y, Lee K, Tang Q, DeFranco AL, Lowell CA. B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):E823-32. PMID: 21911371; PMCID: PMC3193193.
    39. Penaranda C, Tang Q, Bluestone JA. Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells. J Immunol. 2011 Aug 15; 187(4):2015-22. PMID: 21742976; PMCID: PMC3150219.
    40. Brennan TV, Tang Q, Liu FC, Hoang V, Bi M, Bluestone JA, Kang SM. Requirements for prolongation of allograft survival with regulatory T cell infusion in lymphosufficient hosts. J Surg Res. 2011 Jul; 169(1):e69-75. PMID: 21571317; PMCID: PMC3114634.
    41. Nijagal A, Wegorzewska M, Le T, Tang Q, Mackenzie TC. The maternal immune response inhibits the success of in utero hematopoietic cell transplantation. Chimerism. 2011 Apr; 2(2):55-7. PMID: 21912720.
      View in: PubMed
    42. Nijagal A, Wegorzewska M, Jarvis E, Le T, Tang Q, MacKenzie TC. Maternal T cells limit engraftment after in utero hematopoietic cell transplantation in mice. J Clin Invest. 2011 Feb; 121(2):582-92. PMID: 21245575; PMCID: PMC3026737.
    43. Grinberg-Bleyer Y, Baeyens A, You S, Elhage R, Fourcade G, Gregoire S, Cagnard N, Carpentier W, Tang Q, Bluestone J, Chatenoud L, Klatzmann D, Salomon BL, Piaggio E. IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells. J Exp Med. 2010 Aug 30; 207(9):1871-8. PMID: 20679400; PMCID: PMC2931175.
    44. Penaranda C, Tang Q, Ruddle NH, Bluestone JA. Prevention of diabetes by FTY720-mediated stabilization of peri-islet tertiary lymphoid organs. Diabetes. 2010 Jun; 59(6):1461-8. PMID: 20299465; PMCID: PMC2874707.
    45. Fife BT, Pauken KE, Eagar TN, Obu T, Wu J, Tang Q, Azuma M, Krummel MF, Bluestone JA. Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal. Nat Immunol. 2009 Nov; 10(11):1185-92. PMID: 19783989; PMCID: PMC2778301.
    46. Brennan TV, Jaigirdar A, Hoang V, Hayden T, Liu FC, Zaid H, Chang CK, Bucy RP, Tang Q, Kang SM. Preferential priming of alloreactive T cells with indirect reactivity. Am J Transplant. 2009 Apr; 9(4):709-18. PMID: 19344462.
      View in: PubMed
    47. Melli K, Friedman RS, Martin AE, Finger EB, Miao G, Szot GL, Krummel MF, Tang Q. Amplification of autoimmune response through induction of dendritic cell maturation in inflamed tissues. J Immunol. 2009 Mar 01; 182(5):2590-600. PMID: 19234153; PMCID: PMC3057894.
    48. Bluestone JA, Tang Q, Sedwick CE. T regulatory cells in autoimmune diabetes: past challenges, future prospects. J Clin Immunol. 2008 Nov; 28(6):677-84. PMID: 18716861.
      View in: PubMed
    49. Meagher C, Tang Q, Fife BT, Bour-Jordan H, Wu J, Pardoux C, Bi M, Melli K, Bluestone JA. Spontaneous development of a pancreatic exocrine disease in CD28-deficient NOD mice. J Immunol. 2008 Jun 15; 180(12):7793-803. PMID: 18523243; PMCID: PMC2429990.
    50. Tang Q, Adams JY, Penaranda C, Melli K, Piaggio E, Sgouroudis E, Piccirillo CA, Salomon BL, Bluestone JA. Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity. 2008 May; 28(5):687-97. PMID: 18468463; PMCID: PMC2394854.
    51. Tang Q, Bluestone JA. The Foxp3+ regulatory T cell: a jack of all trades, master of regulation. Nat Immunol. 2008 Mar; 9(3):239-44. PMID: 18285775; PMCID: PMC3075612.
    52. Travis MA, Reizis B, Melton AC, Masteller E, Tang Q, Proctor JM, Wang Y, Bernstein X, Huang X, Reichardt LF, Bluestone JA, Sheppard D. Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice. Nature. 2007 Sep 20; 449(7160):361-5. PMID: 17694047; PMCID: PMC2670239.
    53. Sherry NA, Chen W, Kushner JA, Glandt M, Tang Q, Tsai S, Santamaria P, Bluestone JA, Brillantes AM, Herold KC. Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monoclonal antibody by enhancing recovery of beta-cells. Endocrinology. 2007 Nov; 148(11):5136-44. PMID: 17673522.
      View in: PubMed
    54. Guleria I, Gubbels Bupp M, Dada S, Fife B, Tang Q, Ansari MJ, Trikudanathan S, Vadivel N, Fiorina P, Yagita H, Azuma M, Atkinson M, Bluestone JA, Sayegh MH. Mechanisms of PDL1-mediated regulation of autoimmune diabetes. Clin Immunol. 2007 Oct; 125(1):16-25. PMID: 17627890.
      View in: PubMed
    55. Kang SM, Tang Q, Bluestone JA. CD4+CD25+ regulatory T cells in transplantation: progress, challenges and prospects. Am J Transplant. 2007 Jun; 7(6):1457-63. PMID: 17511675.
      View in: PubMed
    56. Fife BT, Guleria I, Gubbels Bupp M, Eagar TN, Tang Q, Bour-Jordan H, Yagita H, Azuma M, Sayegh MH, Bluestone JA. Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway. J Exp Med. 2006 Nov 27; 203(12):2737-47. PMID: 17116737; PMCID: PMC2118162.
    57. Tang Q, Bluestone JA. Regulatory T-cell physiology and application to treat autoimmunity. Immunol Rev. 2006 Aug; 212:217-37. PMID: 16903917.
      View in: PubMed
    58. Scalapino KJ, Tang Q, Bluestone JA, Bonyhadi ML, Daikh DI. Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells. J Immunol. 2006 Aug 01; 177(3):1451-9. PMID: 16849451.
      View in: PubMed
    59. Tang Q, Krummel MF. Imaging the function of regulatory T cells in vivo. Curr Opin Immunol. 2006 Aug; 18(4):496-502. PMID: 16765579.
      View in: PubMed
    60. Tang Q, Bluestone JA. Plasmacytoid DCs and T(reg) cells: casual acquaintance or monogamous relationship? Nat Immunol. 2006 Jun; 7(6):551-3. PMID: 16715063.
      View in: PubMed
    61. Masteller EL, Tang Q, Bluestone JA. Antigen-specific regulatory T cells--ex vivo expansion and therapeutic potential. Semin Immunol. 2006 Apr; 18(2):103-10. PMID: 16458533.
      View in: PubMed
    62. Trenado A, Sudres M, Tang Q, Maury S, Charlotte F, Grégoire S, Bonyhadi M, Klatzmann D, Salomon BL, Cohen JL. Ex vivo-expanded CD4+CD25+ immunoregulatory T cells prevent graft-versus-host-disease by inhibiting activation/differentiation of pathogenic T cells. J Immunol. 2006 Jan 15; 176(2):1266-73. PMID: 16394018.
      View in: PubMed
    63. Tang Q, Adams JY, Tooley AJ, Bi M, Fife BT, Serra P, Santamaria P, Locksley RM, Krummel MF, Bluestone JA. Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat Immunol. 2006 Jan; 7(1):83-92. PMID: 16311599; PMCID: PMC3057888.
    64. Bluestone JA, Tang Q. How do CD4+CD25+ regulatory T cells control autoimmunity? Curr Opin Immunol. 2005 Dec; 17(6):638-42. PMID: 16209918.
      View in: PubMed
    65. Masteller EL, Warner MR, Tang Q, Tarbell KV, McDevitt H, Bluestone JA. Expansion of functional endogenous antigen-specific CD4+CD25+ regulatory T cells from nonobese diabetic mice. J Immunol. 2005 Sep 01; 175(5):3053-9. PMID: 16116193.
      View in: PubMed
    66. Earle KE, Tang Q, Zhou X, Liu W, Zhu S, Bonyhadi ML, Bluestone JA. In vitro expanded human CD4+CD25+ regulatory T cells suppress effector T cell proliferation. Clin Immunol. 2005 Apr; 115(1):3-9. PMID: 15870014.
      View in: PubMed
    67. Tang Q, Boden EK, Henriksen KJ, Bour-Jordan H, Bi M, Bluestone JA. Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function. Eur J Immunol. 2004 Nov; 34(11):2996-3005. PMID: 15468055.
      View in: PubMed
    68. Bluestone JA, Tang Q. Therapeutic vaccination using CD4+CD25+ antigen-specific regulatory T cells. Proc Natl Acad Sci U S A. 2004 Oct 05; 101 Suppl 2:14622-6. PMID: 15322272; PMCID: PMC521996.
    69. Tang Q, Henriksen KJ, Bi M, Finger EB, Szot G, Ye J, Masteller EL, McDevitt H, Bonyhadi M, Bluestone JA. In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J Exp Med. 2004 Jun 07; 199(11):1455-65. PMID: 15184499; PMCID: PMC2211775.
    70. Eagar TN, Tang Q, Wolfe M, He Y, Pear WS, Bluestone JA. Notch 1 signaling regulates peripheral T cell activation. Immunity. 2004 Apr; 20(4):407-15. PMID: 15084270.
      View in: PubMed
    71. Tang Q, Henriksen KJ, Boden EK, Tooley AJ, Ye J, Subudhi SK, Zheng XX, Strom TB, Bluestone JA. Cutting edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory T cells. J Immunol. 2003 Oct 01; 171(7):3348-52. PMID: 14500627.
      View in: PubMed
    72. Tang Q, Smith JA, Szot GL, Zhou P, Alegre ML, Henriksen KJ, Thompson CB, Bluestone JA. CD28/B7 regulation of anti-CD3-mediated immunosuppression in vivo. J Immunol. 2003 Feb 01; 170(3):1510-6. PMID: 12538715.
      View in: PubMed
    73. Bour-Jordan H, Grogan JL, Tang Q, Auger JA, Locksley RM, Bluestone JA. CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment. Nat Immunol. 2003 Feb; 4(2):182-8. PMID: 12524538.
      View in: PubMed
    74. Boden E, Tang Q, Bour-Jordan H, Bluestone JA. The role of CD28 and CTLA4 in the function and homeostasis of CD4+CD25+ regulatory T cells. Novartis Found Symp. 2003; 252:55-63; discussion 63-6, 106-14. PMID: 14609212.
      View in: PubMed
    75. Tang Q, Subudhi SK, Henriksen KJ, Long CG, Vives F, Bluestone JA. The Src family kinase Fyn mediates signals induced by TCR antagonists. J Immunol. 2002 May 01; 168(9):4480-7. PMID: 11970992.
      View in: PubMed
    76. Allenspach EJ, Cullinan P, Tong J, Tang Q, Tesciuba AG, Cannon JL, Takahashi SM, Morgan R, Burkhardt JK, Sperling AI. ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse. Immunity. 2001 Nov; 15(5):739-50. PMID: 11728336.
      View in: PubMed
    77. O'Herrin SM, Slansky JE, Tang Q, Markiewicz MA, Gajewski TF, Pardoll DM, Schneck JP, Bluestone JA. Antigen-specific blockade of T cells in vivo using dimeric MHC peptide. J Immunol. 2001 Sep 01; 167(5):2555-60. PMID: 11509595.
      View in: PubMed
    78. Griffin MD, Holman PO, Tang Q, Ashourian N, Korthäuer U, Kranz DM, Bluestone JA. Development and applications of surface-linked single chain antibodies against T-cell antigens. J Immunol Methods. 2001 Feb 01; 248(1-2):77-90. PMID: 11223070.
      View in: PubMed
    79. Smith JA, Tang Q, Bluestone JA. Partial TCR signals delivered by FcR-nonbinding anti-CD3 monoclonal antibodies differentially regulate individual Th subsets. J Immunol. 1998 May 15; 160(10):4841-9. PMID: 9590231.
      View in: PubMed
    80. Sciammas R, Kodukula P, Tang Q, Hendricks RL, Bluestone JA. T cell receptor-gamma/delta cells protect mice from herpes simplex virus type 1-induced lethal encephalitis. J Exp Med. 1997 Jun 02; 185(11):1969-75. PMID: 9166426; PMCID: PMC2196341.
    81. Tang Q, Chen W, Hendricks RL. Proinflammatory functions of IL-2 in herpes simplex virus corneal infection. J Immunol. 1997 Feb 01; 158(3):1275-83. PMID: 9013970.
      View in: PubMed
    82. Tang Q, Hendricks RL. Interferon gamma regulates platelet endothelial cell adhesion molecule 1 expression and neutrophil infiltration into herpes simplex virus-infected mouse corneas. J Exp Med. 1996 Oct 01; 184(4):1435-47. PMID: 8879215; PMCID: PMC2192815.
    83. Chen W, Tang Q, Hendricks RL. Ex vivo model of leukocyte migration into herpes simplex virus-infected mouse corneas. J Leukoc Biol. 1996 Aug; 60(2):167-73. PMID: 8773577.
      View in: PubMed
    84. Liu T, Tang Q, Hendricks RL. Inflammatory infiltration of the trigeminal ganglion after herpes simplex virus type 1 corneal infection. J Virol. 1996 Jan; 70(1):264-71. PMID: 8523535; PMCID: PMC189813.
    85. Dennis RF, Siemasko KF, Tang Q, Hendricks RL, Finnegan A. Involvement of LFA-1 and ICAM-1 in the herpetic disease resulting from HSV-1 corneal infection. Curr Eye Res. 1995 Jan; 14(1):55-62. PMID: 7720405.
      View in: PubMed
    86. Dingwell KS, Brunetti CR, Hendricks RL, Tang Q, Tang Q, Rainbow AJ, Johnson DC. Herpes simplex virus glycoproteins E and I facilitate cell-to-cell spread in vivo and across junctions of cultured cells. J Virol. 1994 Feb; 68(2):834-45. PMID: 8289387; PMCID: PMC236520.
    87. Cubitt CL, Tang Q, Monteiro CA, Lausch RN, Oakes JE. IL-8 gene expression in cultures of human corneal epithelial cells and keratocytes. Invest Ophthalmol Vis Sci. 1993 Oct; 34(11):3199-206. PMID: 7691777.
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