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Qizhi Tang, PhD

Title(s)Professor, Surgery
SchoolSchool of Medicine
Address513 Parnassus Ave, HSE
San Francisco CA 94143
Phone415-476-1739
ORCID ORCID Icon0000-0001-7313-3574 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral Studies2002Graduate Division
    Univeristy of ChicagoPostdoctoral Studies2000Immunology
    University of Illinios, ChicagoPhD1996Microbiology and Immunology
    University of South AlabamaGraduate School1991Microbiology and Immunology
    Peking Union Medical CollegeMedical School1989Medcine

    Collapse Overview 
    Collapse Overview
    The Tang lab focuses on translating knowledge on mechanisms of immune tolerance into novel therapeutics for treating autoimmune diabetes and preventing transplant rejection. Currently, two major areas of work are on therapeutic application of regulatory T cell therapy in type 1 diabetes and transplantation and immune modulation to enable immune suppression-free transplant of stem-cell-derived beta cells for treatment of type 1 diabetes.

    Regulatory T cells are a small population of white blood cells that are essential for preventing tissue damages caused by over activation of the immune system. The Tang lab has shown that infusion of regulatory T cells in animal models can reverse type 1 diabetes, a disease caused by immune destruction of insulin-producing cells in the pancreatic islets. Similarly, regulatory T cell therapy can prevent rejection of transplanted organs in animal models. A joint team of researchers from the Tang and Bluestone labs is currently conducting 6 clinical trials evaluating the safety and efficacy of regulatory T cell therapy in patients. In the mean time, we are developing next generation regulatory T cell therapies in preclinical models to improve the safety and efficacy of the therapy.

    In patients with chronic type 1 diabetes, transplanting of stem-cell-derived beta cells can potentially cure the disease, but patients have to commit to life-long immunosuppression to prevent rejection of the transplanted cells from rejection by the immune system. The Tang lab is currently investigating approaches to shield the transplanted cells from the immune systems using novel biomaterials developed in the Desai and Roy labs at UCSF. We are also applying genome-editing technologies to immunoengineer stem cells to evade immune rejection.

    Collapse Research 
    Collapse Research Activities and Funding
    Islet transplant operational tolerance through minimization of ischemic injury and local immune regulation
    JDRF SRA-2019-776-S-BSep 1, 2019 - Aug 31, 2021
    Role: PI
    Pancreatic Islets and Parathyroid Gland Co-transplantation for Treatment of Diabetes in the Intra-Muscular Site: PARADIGM
    CIRM CLIN2-11437Jul 1, 2019 - Jun 30, 2023
    Role: Co-investigator
    Role Description: scientific rationale of the trial was based on research findings in the Tang Lab, which will design and implement mechanistic study associated with this trial.
    Promoting extrahepatic engraftment of human islets by parathyroid gland co-transplantation
    JDRF INO-2018-635-A-NJun 1, 2018 - May 31, 2019
    Role: PI
    Engineering Treg cells to treat type 1 diabetes
    Helmsley Charitable Trust 2018PG-T1D042Nov 1, 2017 - Oct 31, 2020
    Role: PI
    Multiplex in situ gene expression and phenotypical profiling of inflamed tissues
    NIH/NIAID U24AI118675Jun 26, 2015 - May 31, 2020
    Role: Co-Principal Investigator
    Novel Therapies to Modulate the Inflammatory Alloresponse in Renal Grafts
    NIAID 1 U01 AI113362-01Jul 1, 2014 - Jun 30, 2021
    Role: Co-investigator
    Role Description: Drug Master File holder, supervision of Treg manufacturing and mechanistic studies
    Donor-Alloantigen-Reactive Regulatory T Cell Therapy in Liver Transplantation
    NIH/NIAID U01AI110658Jun 1, 2014 - May 31, 2019
    Role: Co-Principal Investigator
    Role Description: Drug Master File holder, supervision of Treg manufacturing and mechanistic studies
    "Donor-Specific Regulatory T Cell Therapy in Liver Transplantation"
    NIH/NIAID R34AI095135Apr 1, 2012 - Mar 31, 2014
    Role: Co-Principal Investigator
    "Regulatory 'T'Cell Control of Autoimmune Diabetes".
    NIH/NIDDK R01DK085231Mar 15, 2010 - Feb 28, 2015
    Role: Principal Investigator
    BD FACS ARIA II CELL SORTER
    NIH/NCRR S10RR027088Feb 1, 2010 - Jan 31, 2011
    Role: Principal Investigator
    Visualizing regulatory T cell control of autoimmunity
    NIH/NIAID R21AI066097Jul 1, 2005 - Jun 30, 2008
    Role: Principal Investigator
    Diabetes Research Center
    NIH/NIDDK P30DK063720May 1, 2003 - Mar 31, 2020
    Role: Co-Investigator
    T CELL ACTIVATION AND ANERGY INDUCTION BY ANTI-CD3
    NIH/NIAID F32AI010360Feb 1, 2000
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Novel In Situ Hybridization and Multiplex Immunofluorescence Technology Combined With Whole-slide Digital Image Analysis in Kidney Transplantation. J Histochem Cytochem. 2020 Jul; 68(7):445-459. Junger H, Dobi D, Chen A, Lee L, Vasquez JJ, Tang Q, Laszik ZG. PMID: 32609561.
      View in: PubMed   Mentions:    Fields:    
    2. Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials. Lancet. 2020 05 23; 395(10237):1627-1639. Sawitzki B, Harden PN, Reinke P, Moreau A, Hutchinson JA, Game DS, Tang Q, Guinan EC, Battaglia M, Burlingham WJ, Roberts ISD, Streitz M, Josien R, Böger CA, Scottà C, Markmann JF, Hester JL, Juerchott K, Braudeau C, James B, Contreras-Ruiz L, van der Net JB, Bergler T, Caldara R, Petchey W, Edinger M, Dupas N, Kapinsky M, Mutzbauer I, Otto NM, Öllinger R, Hernandez-Fuentes MP, Issa F, Ahrens N, Meyenberg C, Karitzky S, Kunzendorf U, Knechtle SJ, Grinyó J, Morris PJ, Brent L, Bushell A, Turka LA, Bluestone JA, Lechler RI, Schlitt HJ, Cuturi MC, Schlickeiser S, Friend PJ, Miloud T, Scheffold A, Secchi A, Crisalli K, Kang SM, Hilton R, Banas B, Blancho G, Volk HD, Lombardi G, Wood KJ, Geissler EK. PMID: 32446407.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Next-generation regulatory T cell therapy. Nat Rev Drug Discov. 2019 10; 18(10):749-769. Ferreira LMR, Muller YD, Bluestone JA, Tang Q. PMID: 31541224.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    4. Supporting Survival of Transplanted Stem-Cell-Derived Insulin-Producing Cells in an Encapsulation Device Augmented with Controlled Release of Amino Acids. Adv Biosyst. 2019 Sep; 3(9). Chendke GS, Faleo G, Juang C, Parent AV, Bernards DA, Hebrok M, Tang Q, Desai TA. PMID: 31633004.
      View in: PubMed   Mentions:
    5. NextGen cell-based immunotherapies in cancer and other immune disorders. Curr Opin Immunol. 2019 08; 59:79-87. Azimi CS, Tang Q, Roybal KT, Bluestone JA. PMID: 31071513.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    6. NKG2C Natural Killer Cells in Bronchoalveolar Lavage Are Associated With Cytomegalovirus Viremia and Poor Outcomes in Lung Allograft Recipients. Transplantation. 2019 03; 103(3):493-501. Calabrese DR, Chong T, Wang A, Singer JP, Gottschall M, Hays SR, Golden JA, Kukreja J, Lanier LL, Tang Q, Greenland JR. PMID: 30211828.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    7. Adoptive Treg Cell Therapy in a Patient With Systemic Lupus Erythematosus. Arthritis Rheumatol. 2019 03; 71(3):431-440. Dall'Era M, Pauli ML, Remedios K, Taravati K, Sandova PM, Putnam AL, Lares A, Haemel A, Tang Q, Hellerstein M, Fitch M, McNamara J, Welch B, Bluestone JA, Wofsy D, Rosenblum MD. PMID: 30277008.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    8. Early expansion of donor-specific Tregs in tolerant kidney transplant recipients. JCI Insight. 2018 11 15; 3(22). Savage TM, Shonts BA, Obradovic A, Dewolf S, Lau S, Zuber J, Simpson MT, Berglund E, Fu J, Yang S, Ho SH, Tang Q, Turka LA, Shen Y, Sykes M. PMID: 30429370.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    9. Islet encapsulation therapy - racing towards the finish line? Nat Rev Endocrinol. 2018 11; 14(11):630-632. Desai TA, Tang Q. PMID: 30275463.
      View in: PubMed   Mentions:    Fields:    
    10. Regulatory T-cell therapy for autoimmune and autoinflammatory diseases: The next frontier. J Allergy Clin Immunol. 2018 12; 142(6):1710-1718. Esensten JH, Muller YD, Bluestone JA, Tang Q. PMID: 30367909.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    11. Treg cells-the next frontier of cell therapy. Science. 2018 10 12; 362(6411):154-155. Bluestone JA, Tang Q. PMID: 30309932.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    12. Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells. Transplantation. 2018 08; 102(8):1223-1229. Odorico J, Markmann J, Melton D, Greenstein J, Hwa A, Nostro C, Rezania A, Oberholzer J, Pipeleers D, Yang L, Cowan C, Huangfu D, Egli D, Ben-David U, Vallier L, Grey ST, Tang Q, Roep B, Ricordi C, Naji A, Orlando G, Anderson DG, Poznansky M, Ludwig B, Tomei A, Greiner DL, Graham M, Carpenter M, Migliaccio G, D'Amour K, Hering B, Piemonti L, Berney T, Rickels M, Kay T, Adams A. PMID: 29781950.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    13. Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges. Cell Stem Cell. 2018 Jun 01; 22(6):810-823. Sneddon JB, Tang Q, Stock P, Bluestone JA, Roy S, Desai T, Hebrok M. PMID: 29859172.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    14. Suppressed calcineurin-dependent gene expression identifies lung allograft recipients at increased risk of infection. Am J Transplant. 2018 08; 18(8):2043-2049. Greenland JR, Chong T, Wang AS, Martinez E, Shrestha P, Kukreja J, Hays SR, Golden JA, Singer JP, Tang Q. PMID: 29673076.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Revealing the specificity of regulatory T cells in murine autoimmune diabetes. Proc Natl Acad Sci U S A. 2018 05 15; 115(20):5265-5270. Spence A, Purtha W, Tam J, Dong S, Kim Y, Ju CH, Sterling T, Nakayama M, Robinson WH, Bluestone JA, Anderson MS, Tang Q. PMID: 29712852.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    16. Alloreactive fetal T cells promote uterine contractility in preterm labor via IFN-? and TNF-a. Sci Transl Med. 2018 04 25; 10(438). Frascoli M, Coniglio L, Witt R, Jeanty C, Fleck-Derderian S, Myers DE, Lee TH, Keating S, Busch MP, Norris PJ, Tang Q, Cruz G, Barcellos LF, Gomez-Lopez N, Romero R, MacKenzie TC. PMID: 29695455.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    17. Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization. Front Immunol. 2017; 8:1844. Fuchs A, Gliwinski M, Grageda N, Spiering R, Abbas AK, Appel S, Bacchetta R, Battaglia M, Berglund D, Blazar B, Bluestone JA, Bornhäuser M, Ten Brinke A, Brusko TM, Cools N, Cuturi MC, Geissler E, Giannoukakis N, Golab K, Hafler DA, van Ham SM, Hester J, Hippen K, Di Ianni M, Ilic N, Isaacs J, Issa F, Iwaszkiewicz-Grzes D, Jaeckel E, Joosten I, Klatzmann D, Koenen H, van Kooten C, Korsgren O, Kretschmer K, Levings M, Marek-Trzonkowska NM, Martinez-Llordella M, Miljkovic D, Mills KHG, Miranda JP, Piccirillo CA, Putnam AL, Ritter T, Roncarolo MG, Sakaguchi S, Sánchez-Ramón S, Sawitzki B, Sofronic-Milosavljevic L, Sykes M, Tang Q, Vives-Pi M, Waldmann H, Witkowski P, Wood KJ, Gregori S, Hilkens CMU, Lombardi G, Lord P, Martinez-Caceres EM, Trzonkowski P. PMID: 29379498.
      View in: PubMed   Mentions: 3     Fields:    
    18. Mitigating Ischemic Injury of Stem Cell-Derived Insulin-Producing Cells after Transplant. Stem Cell Reports. 2017 09 12; 9(3):807-819. Faleo G, Russ HA, Wisel S, Parent AV, Nguyen V, Nair GG, Freise JE, Villanueva KE, Szot GL, Hebrok M, Tang Q. PMID: 28803916.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    19. Nanoporous Immunoprotective Device for Stem-Cell-Derived ß-Cell Replacement Therapy. ACS Nano. 2017 08 22; 11(8):7747-7757. Chang R, Faleo G, Russ HA, Parent AV, Elledge SK, Bernards DA, Allen JL, Villanueva K, Hebrok M, Tang Q, Desai TA. PMID: 28763191.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    20. Transplant trials with Tregs: perils and promises. J Clin Invest. 2017 Jun 30; 127(7):2505-2512. Tang Q, Vincenti F. PMID: 28665300.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    21. Cutting Edge: Origins, Recruitment, and Regulation of CD11c+ Cells in Inflamed Islets of Autoimmune Diabetes Mice. J Immunol. 2017 07 01; 199(1):27-32. Klementowicz JE, Mahne AE, Spence A, Nguyen V, Satpathy AT, Murphy KM, Tang Q. PMID: 28550204.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    22. Glucose-Stimulated Insulin Response of Silicon Nanopore-Immunoprotected Islets under Convective Transport. ACS Biomater Sci Eng. 2017 Jun 12; 3(6):1051-1061. Song S, Yeung R, Park J, Posselt AM, Desai TA, Tang Q, Roy S. PMID: 29250596.
      View in: PubMed   Mentions:
    23. Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes. Diabetes. 2017 03; 66(3):722-734. Michels AW, Landry LG, McDaniel KA, Yu L, Campbell-Thompson M, Kwok WW, Jones KL, Gottlieb PA, Kappler JW, Tang Q, Roep BO, Atkinson MA, Mathews CE, Nakayama M. PMID: 27920090.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    24. Restoring Regulatory T Cells in Type 1 Diabetes. Curr Diab Rep. 2016 11; 16(11):110. Spence A, Tang Q. PMID: 27664043.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    25. Impact of Immune-Modulatory Drugs on Regulatory T Cell. Transplantation. 2016 Nov; 100(11):2288-2300. Furukawa A, Wisel SA, Tang Q. PMID: 27490409.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    26. Donor-Reactive Regulatory T Cell Frequency Increases During Acute Cellular Rejection of Lung Allografts. Transplantation. 2016 10; 100(10):2090-8. Greenland JR, Wong CM, Ahuja R, Wang AS, Uchida C, Golden JA, Hays SR, Leard LE, Rajalingam R, Singer JP, Kukreja J, Wolters PJ, Caughey GH, Tang Q. PMID: 27077597.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    27. Virtual Global Transplant Laboratory Standard Operating Procedures for Blood Collection, PBMC Isolation, and Storage. Transplant Direct. 2016 Sep; 2(9):e101. Higdon LE, Lee K, Tang Q, Maltzman JS. PMID: 27795993.
      View in: PubMed   Mentions:
    28. Assessment of Immune Isolation of Allogeneic Mouse Pancreatic Progenitor Cells by a Macroencapsulation Device. Transplantation. 2016 06; 100(6):1211-8. Faleo G, Lee K, Nguyen V, Tang Q. PMID: 26982952.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    29. Heightened Immune Activation in Fetuses with Gastroschisis May Be Blocked by Targeting IL-5. J Immunol. 2016 06 15; 196(12):4957-66. Frascoli M, Jeanty C, Fleck S, Moradi PW, Keating S, Mattis AN, Tang Q, MacKenzie TC. PMID: 27183609.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    30. Silicon nanopore membrane (SNM) for islet encapsulation and immunoisolation under convective transport. Sci Rep. 2016 Mar 24; 6:23679. Song S, Faleo G, Yeung R, Kant R, Posselt AM, Desai TA, Tang Q, Roy S. PMID: 27009429.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    31. Approaching a cure for type 1 diabetes. Nat Med. 2016 Mar; 22(3):236-7. Tang Q, Desai TA. PMID: 26937617.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    32. Type 1 diabetes immunotherapy using polyclonal regulatory T cells. Sci Transl Med. 2015 Nov 25; 7(315):315ra189. Bluestone JA, Buckner JH, Fitch M, Gitelman SE, Gupta S, Hellerstein MK, Herold KC, Lares A, Lee MR, Li K, Liu W, Long SA, Masiello LM, Nguyen V, Putnam AL, Rieck M, Sayre PH, Tang Q. PMID: 26606968.
      View in: PubMed   Mentions: 178     Fields:    Translation:HumansCellsCTClinical Trials
    33. Manipulating IL-2 and IL-2R in autoimmune diseases and transplantation. Immunotherapy. 2015; 7(12):1231-4. Zhang M, Tang Q. PMID: 26601714.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    34. Targeting Treg signaling for the treatment of autoimmune diseases. Curr Opin Immunol. 2015 Dec; 37:11-20. Spence A, Klementowicz JE, Bluestone JA, Tang Q. PMID: 26432763.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    35. Therapeutic window of interleukin-2 for autoimmune diseases. Diabetes. 2015 Jun; 64(6):1912-3. Tang Q. PMID: 25999537.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    36. Polycaprolactone Thin-Film Micro- and Nanoporous Cell-Encapsulation Devices. ACS Nano. 2015 Jun 23; 9(6):5675-82. Nyitray CE, Chang R, Faleo G, Lance KD, Bernards DA, Tang Q, Desai TA. PMID: 25950860.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    37. Immunotherapy: making the case for precision medicine. Sci Transl Med. 2015 Mar 25; 7(280):280ed3. Bluestone JA, Tang Q. PMID: 25810308.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    38. Increased maternal T cell microchimerism in the allogeneic fetus during LPS-induced preterm labor in mice. Chimerism. 2014; 5(3-4):68-74. Wegorzewska M, Le T, Tang Q, MacKenzie TC. PMID: 25779065.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    39. Therapeutic regulatory T cells subvert effector T cell function in inflamed islets to halt autoimmune diabetes. J Immunol. 2015 Apr 01; 194(7):3147-55. Mahne AE, Klementowicz JE, Chou A, Nguyen V, Tang Q. PMID: 25732730.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    40. Antigen recognition in the islets changes with progression of autoimmune islet infiltration. J Immunol. 2015 Jan 15; 194(2):522-30. Lindsay RS, Corbin K, Mahne A, Levitt BE, Gebert MJ, Wigton EJ, Bradley BJ, Haskins K, Jacobelli J, Tang Q, Krummel MF, Friedman RS. PMID: 25505281.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    41. Interpretation of transplant biopsies and immune responses following Treg cell therapy. Curr Opin Organ Transplant. 2014 Dec; 19(6):616-20. Tang Q, Kang SM. PMID: 25313874.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    42. Fetal intervention increases maternal T cell awareness of the foreign conceptus and can lead to immune-mediated fetal demise. J Immunol. 2014 Feb 15; 192(4):1938-45. Wegorzewska M, Nijagal A, Wong CM, Le T, Lescano N, Tang Q, MacKenzie TC. PMID: 24415782.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    43. Regulatory T-cell therapy in transplantation: moving to the clinic. Cold Spring Harb Perspect Med. 2013 Nov 01; 3(11). Tang Q, Bluestone JA. PMID: 24186492.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    44. Direct and indirect antigen presentation lead to deletion of donor-specific T cells after in utero hematopoietic cell transplantation in mice. Blood. 2013 May 30; 121(22):4595-602. Nijagal A, Derderian C, Le T, Jarvis E, Nguyen L, Tang Q, Mackenzie TC. PMID: 23610372.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    45. Altered balance between effector T cells and FOXP3+ HELIOS+ regulatory T cells after thymoglobulin induction in kidney transplant recipients. Transpl Int. 2012 Dec; 25(12):1257-67. Tang Q, Leung J, Melli K, Lay K, Chuu EL, Liu W, Bluestone JA, Kang SM, Peddi VR, Vincenti F. PMID: 22994802.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCellsCTClinical Trials
    46. IRE1a induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metab. 2012 Aug 08; 16(2):250-64. Lerner AG, Upton JP, Praveen PV, Ghosh R, Nakagawa Y, Igbaria A, Shen S, Nguyen V, Backes BJ, Heiman M, Heintz N, Greengard P, Hui S, Tang Q, Trusina A, Oakes SA, Papa FR. PMID: 22883233.
      View in: PubMed   Mentions: 205     Fields:    Translation:HumansAnimalsCells
    47. Regulatory T-cell therapy for transplantation: how many cells do we need? Curr Opin Organ Transplant. 2012 Aug; 17(4):349-54. Tang Q, Lee K. PMID: 22790069.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    48. CD4(+)Foxp3(+) regulatory T cell therapy in transplantation. J Mol Cell Biol. 2012 Feb; 4(1):11-21. Tang Q, Bluestone JA, Kang SM. PMID: 22170955.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    49. B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):E823-32. Scapini P, Lamagna C, Hu Y, Lee K, Tang Q, DeFranco AL, Lowell CA. PMID: 21911371.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    50. Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells. J Immunol. 2011 Aug 15; 187(4):2015-22. Penaranda C, Tang Q, Bluestone JA. PMID: 21742976.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    51. Requirements for prolongation of allograft survival with regulatory T cell infusion in lymphosufficient hosts. J Surg Res. 2011 Jul; 169(1):e69-75. Brennan TV, Tang Q, Liu FC, Hoang V, Bi M, Bluestone JA, Kang SM. PMID: 21571317.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    52. The maternal immune response inhibits the success of in utero hematopoietic cell transplantation. Chimerism. 2011 Apr; 2(2):55-7. Nijagal A, Wegorzewska M, Le T, Tang Q, Mackenzie TC. PMID: 21912720.
      View in: PubMed   Mentions: 5     Fields:    
    53. Maternal T cells limit engraftment after in utero hematopoietic cell transplantation in mice. J Clin Invest. 2011 Feb; 121(2):582-92. Nijagal A, Wegorzewska M, Jarvis E, Le T, Tang Q, MacKenzie TC. PMID: 21245575.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    54. IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells. J Exp Med. 2010 Aug 30; 207(9):1871-8. Grinberg-Bleyer Y, Baeyens A, You S, Elhage R, Fourcade G, Gregoire S, Cagnard N, Carpentier W, Tang Q, Bluestone J, Chatenoud L, Klatzmann D, Salomon BL, Piaggio E. PMID: 20679400.
      View in: PubMed   Mentions: 145     Fields:    Translation:AnimalsCells
    55. Prevention of diabetes by FTY720-mediated stabilization of peri-islet tertiary lymphoid organs. Diabetes. 2010 Jun; 59(6):1461-8. Penaranda C, Tang Q, Ruddle NH, Bluestone JA. PMID: 20299465.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    56. Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal. Nat Immunol. 2009 Nov; 10(11):1185-92. Fife BT, Pauken KE, Eagar TN, Obu T, Wu J, Tang Q, Azuma M, Krummel MF, Bluestone JA. PMID: 19783989.
      View in: PubMed   Mentions: 229     Fields:    Translation:AnimalsCells
    57. Amplification of autoimmune response through induction of dendritic cell maturation in inflamed tissues. J Immunol. 2009 Mar 01; 182(5):2590-600. Melli K, Friedman RS, Martin AE, Finger EB, Miao G, Szot GL, Krummel MF, Tang Q. PMID: 19234153.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    58. T regulatory cells in autoimmune diabetes: past challenges, future prospects. J Clin Immunol. 2008 Nov; 28(6):677-84. Bluestone JA, Tang Q, Sedwick CE. PMID: 18716861.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    59. Spontaneous development of a pancreatic exocrine disease in CD28-deficient NOD mice. J Immunol. 2008 Jun 15; 180(12):7793-803. Meagher C, Tang Q, Fife BT, Bour-Jordan H, Wu J, Pardoux C, Bi M, Melli K, Bluestone JA. PMID: 18523243.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    60. Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity. 2008 May; 28(5):687-97. Tang Q, Adams JY, Penaranda C, Melli K, Piaggio E, Sgouroudis E, Piccirillo CA, Salomon BL, Bluestone JA. PMID: 18468463.
      View in: PubMed   Mentions: 304     Fields:    Translation:AnimalsCells
    61. The Foxp3+ regulatory T cell: a jack of all trades, master of regulation. Nat Immunol. 2008 Mar; 9(3):239-44. Tang Q, Bluestone JA. PMID: 18285775.
      View in: PubMed   Mentions: 355     Fields:    Translation:HumansAnimalsCells
    62. Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice. Nature. 2007 Sep 20; 449(7160):361-5. Travis MA, Reizis B, Melton AC, Masteller E, Tang Q, Proctor JM, Wang Y, Bernstein X, Huang X, Reichardt LF, Bluestone JA, Sheppard D. PMID: 17694047.
      View in: PubMed   Mentions: 218     Fields:    Translation:AnimalsCells
    63. Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monoclonal antibody by enhancing recovery of beta-cells. Endocrinology. 2007 Nov; 148(11):5136-44. Sherry NA, Chen W, Kushner JA, Glandt M, Tang Q, Tsai S, Santamaria P, Bluestone JA, Brillantes AM, Herold KC. PMID: 17673522.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    64. Mechanisms of PDL1-mediated regulation of autoimmune diabetes. Clin Immunol. 2007 Oct; 125(1):16-25. Guleria I, Gubbels Bupp M, Dada S, Fife B, Tang Q, Ansari MJ, Trikudanathan S, Vadivel N, Fiorina P, Yagita H, Azuma M, Atkinson M, Bluestone JA, Sayegh MH. PMID: 17627890.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    65. Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway. J Exp Med. 2006 Nov 27; 203(12):2737-47. Fife BT, Guleria I, Gubbels Bupp M, Eagar TN, Tang Q, Bour-Jordan H, Yagita H, Azuma M, Sayegh MH, Bluestone JA. PMID: 17116737.
      View in: PubMed   Mentions: 128     Fields:    Translation:AnimalsCells
    66. Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells. J Immunol. 2006 Aug 01; 177(3):1451-9. Scalapino KJ, Tang Q, Bluestone JA, Bonyhadi ML, Daikh DI. PMID: 16849451.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    67. Regulatory T-cell physiology and application to treat autoimmunity. Immunol Rev. 2006 Aug; 212:217-37. Tang Q, Bluestone JA. PMID: 16903917.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    68. Imaging the function of regulatory T cells in vivo. Curr Opin Immunol. 2006 Aug; 18(4):496-502. Tang Q, Krummel MF. PMID: 16765579.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    69. Plasmacytoid DCs and T(reg) cells: casual acquaintance or monogamous relationship? Nat Immunol. 2006 Jun; 7(6):551-3. Tang Q, Bluestone JA. PMID: 16715063.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    70. Antigen-specific regulatory T cells--ex vivo expansion and therapeutic potential. Semin Immunol. 2006 Apr; 18(2):103-10. Masteller EL, Tang Q, Bluestone JA. PMID: 16458533.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    71. Ex vivo-expanded CD4+CD25+ immunoregulatory T cells prevent graft-versus-host-disease by inhibiting activation/differentiation of pathogenic T cells. J Immunol. 2006 Jan 15; 176(2):1266-73. Trenado A, Sudres M, Tang Q, Maury S, Charlotte F, Grégoire S, Bonyhadi M, Klatzmann D, Salomon BL, Cohen JL. PMID: 16394018.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    72. Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat Immunol. 2006 Jan; 7(1):83-92. Tang Q, Adams JY, Tooley AJ, Bi M, Fife BT, Serra P, Santamaria P, Locksley RM, Krummel MF, Bluestone JA. PMID: 16311599.
      View in: PubMed   Mentions: 295     Fields:    Translation:AnimalsCells
    73. How do CD4+CD25+ regulatory T cells control autoimmunity? Curr Opin Immunol. 2005 Dec; 17(6):638-42. Bluestone JA, Tang Q. PMID: 16209918.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    74. Expansion of functional endogenous antigen-specific CD4+CD25+ regulatory T cells from nonobese diabetic mice. J Immunol. 2005 Sep 01; 175(5):3053-9. Masteller EL, Warner MR, Tang Q, Tarbell KV, McDevitt H, Bluestone JA. PMID: 16116193.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    75. Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function. Eur J Immunol. 2004 Nov; 34(11):2996-3005. Tang Q, Boden EK, Henriksen KJ, Bour-Jordan H, Bi M, Bluestone JA. PMID: 15468055.
      View in: PubMed   Mentions: 123     Fields:    Translation:AnimalsCells
    76. Therapeutic vaccination using CD4+CD25+ antigen-specific regulatory T cells. Proc Natl Acad Sci U S A. 2004 Oct 05; 101 Suppl 2:14622-6. Bluestone JA, Tang Q. PMID: 15322272.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    77. In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J Exp Med. 2004 Jun 07; 199(11):1455-65. Tang Q, Henriksen KJ, Bi M, Finger EB, Szot G, Ye J, Masteller EL, McDevitt H, Bonyhadi M, Bluestone JA. PMID: 15184499.
      View in: PubMed   Mentions: 360     Fields:    Translation:AnimalsCells
    78. Notch 1 signaling regulates peripheral T cell activation. Immunity. 2004 Apr; 20(4):407-15. Eagar TN, Tang Q, Wolfe M, He Y, Pear WS, Bluestone JA. PMID: 15084270.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    79. Cutting edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory T cells. J Immunol. 2003 Oct 01; 171(7):3348-52. Tang Q, Henriksen KJ, Boden EK, Tooley AJ, Ye J, Subudhi SK, Zheng XX, Strom TB, Bluestone JA. PMID: 14500627.
      View in: PubMed   Mentions: 204     Fields:    Translation:AnimalsCells
    80. CD28/B7 regulation of anti-CD3-mediated immunosuppression in vivo. J Immunol. 2003 Feb 01; 170(3):1510-6. Tang Q, Smith JA, Szot GL, Zhou P, Alegre ML, Henriksen KJ, Thompson CB, Bluestone JA. PMID: 12538715.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    81. CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment. Nat Immunol. 2003 Feb; 4(2):182-8. Bour-Jordan H, Grogan JL, Tang Q, Auger JA, Locksley RM, Bluestone JA. PMID: 12524538.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    82. The role of CD28 and CTLA4 in the function and homeostasis of CD4+CD25+ regulatory T cells. Novartis Found Symp. 2003; 252:55-63; discussion 63-6, 106-14. Boden E, Tang Q, Bour-Jordan H, Bluestone JA. PMID: 14609212.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    83. The Src family kinase Fyn mediates signals induced by TCR antagonists. J Immunol. 2002 May 01; 168(9):4480-7. Tang Q, Subudhi SK, Henriksen KJ, Long CG, Vives F, Bluestone JA. PMID: 11970992.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    84. ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse. Immunity. 2001 Nov; 15(5):739-50. Allenspach EJ, Cullinan P, Tong J, Tang Q, Tesciuba AG, Cannon JL, Takahashi SM, Morgan R, Burkhardt JK, Sperling AI. PMID: 11728336.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    85. Antigen-specific blockade of T cells in vivo using dimeric MHC peptide. J Immunol. 2001 Sep 01; 167(5):2555-60. O'Herrin SM, Slansky JE, Tang Q, Markiewicz MA, Gajewski TF, Pardoll DM, Schneck JP, Bluestone JA. PMID: 11509595.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    86. Development and applications of surface-linked single chain antibodies against T-cell antigens. J Immunol Methods. 2001 Feb 01; 248(1-2):77-90. Griffin MD, Holman PO, Tang Q, Ashourian N, Korthäuer U, Kranz DM, Bluestone JA. PMID: 11223070.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    87. Partial TCR signals delivered by FcR-nonbinding anti-CD3 monoclonal antibodies differentially regulate individual Th subsets. J Immunol. 1998 May 15; 160(10):4841-9. Smith JA, Tang Q, Bluestone JA. PMID: 9590231.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    88. T cell receptor-gamma/delta cells protect mice from herpes simplex virus type 1-induced lethal encephalitis. J Exp Med. 1997 Jun 02; 185(11):1969-75. Sciammas R, Kodukula P, Tang Q, Hendricks RL, Bluestone JA. PMID: 9166426.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    89. Proinflammatory functions of IL-2 in herpes simplex virus corneal infection. J Immunol. 1997 Feb 01; 158(3):1275-83. Tang Q, Chen W, Hendricks RL. PMID: 9013970.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    90. Interferon gamma regulates platelet endothelial cell adhesion molecule 1 expression and neutrophil infiltration into herpes simplex virus-infected mouse corneas. J Exp Med. 1996 Oct 01; 184(4):1435-47. Tang Q, Hendricks RL. PMID: 8879215.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    91. Ex vivo model of leukocyte migration into herpes simplex virus-infected mouse corneas. J Leukoc Biol. 1996 Aug; 60(2):167-73. Chen W, Tang Q, Hendricks RL. PMID: 8773577.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    92. Inflammatory infiltration of the trigeminal ganglion after herpes simplex virus type 1 corneal infection. J Virol. 1996 Jan; 70(1):264-71. Liu T, Tang Q, Hendricks RL. PMID: 8523535.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    93. Involvement of LFA-1 and ICAM-1 in the herpetic disease resulting from HSV-1 corneal infection. Curr Eye Res. 1995 Jan; 14(1):55-62. Dennis RF, Siemasko KF, Tang Q, Hendricks RL, Finnegan A. PMID: 7720405.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    94. Herpes simplex virus glycoproteins E and I facilitate cell-to-cell spread in vivo and across junctions of cultured cells. J Virol. 1994 Feb; 68(2):834-45. Dingwell KS, Brunetti CR, Hendricks RL, Tang Q, Tang M, Rainbow AJ, Johnson DC. PMID: 8289387.
      View in: PubMed   Mentions: 149     Fields:    Translation:HumansAnimalsCells
    95. IL-8 gene expression in cultures of human corneal epithelial cells and keratocytes. Invest Ophthalmol Vis Sci. 1993 Oct; 34(11):3199-206. Cubitt CL, Tang Q, Monteiro CA, Lausch RN, Oakes JE. PMID: 7691777.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
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