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Bradley Backes, PhD

TitleAssociate Professor
SchoolUCSF School of Medicine
DepartmentMedicine
Address1700 4th Street
San Francisco CA 94158
Phone415-502-2185
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    Collapse Research 
    Collapse Research Activities and Funding
    IRE1 alpha inhibitors for Retinal Degenerative Diseases
    NIH R41EY026370Sep 30, 2015 - Sep 29, 2016
    Role: Principal Investigator
    IRE1 alpha inhibitors for type 2 diabetes
    NIH R41DK108377Sep 21, 2015 - Aug 31, 2016
    Role: Principal Investigator
    Inflammasome Inhibitors for Type 2 Diabetes
    NIH R43DK094627Sep 18, 2012 - Aug 31, 2013
    Role: Principal Investigator
    Targeting epithelial cells to treat pulmonary fibrosis
    NIH/NHLBI P01HL108794Aug 9, 2012 - Jul 31, 2017
    Role: Co-Investigator
    Developing UPR Modulators as Novel Therapeutics for Neurodegeneration
    NIH R41NS070401Feb 1, 2011 - Jul 31, 2012
    Role: Principal Investigator
    Cytoprotective Effects of UPR Modulators in ER Stress-Challenged beta-Cells
    NIH R41DK083093Sep 10, 2009 - Dec 31, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Morita S, Villalta SA, Feldman HC, Register AC, Rosenthal W, Hoffmann-Petersen IT, Mehdizadeh M, Ghosh R, Wang L, Colon-Negron K, Meza-Acevedo R, Backes BJ, Maly DJ, Bluestone JA, Papa FR. Targeting ABL-IRE1a Signaling Spares ER-Stressed Pancreatic ß Cells to Reverse Autoimmune Diabetes. Cell Metab. 2017 Apr 04; 25(4):883-897.e8. PMID: 28380378.
      View in: PubMed
    2. Feldman HC, Tong M, Wang L, Meza-Acevedo R, Gobillot TA, Lebedev I, Gliedt MJ, Hari SB, Mitra AK, Backes BJ, Papa FR, Seeliger MA, Maly DJ. Structural and Functional Analysis of the Allosteric Inhibition of IRE1a with ATP-Competitive Ligands. ACS Chem Biol. 2016 Aug 19; 11(8):2195-205. PMID: 27227314.
      View in: PubMed
    3. Ghosh R, Wang L, Wang ES, Perera BG, Igbaria A, Morita S, Prado K, Thamsen M, Caswell D, Macias H, Weiberth KF, Gliedt MJ, Alavi MV, Hari SB, Mitra AK, Bhhatarai B, Schürer SC, Snapp EL, Gould DB, German MS, Backes BJ, Maly DJ, Oakes SA, Papa FR. Allosteric inhibition of the IRE1a RNase preserves cell viability and function during endoplasmic reticulum stress. Cell. 2014 Jul 31; 158(3):534-48. PMID: 25018104; PMCID: PMC4244221.
    4. Wang L, Perera BG, Hari SB, Bhhatarai B, Backes BJ, Seeliger MA, Schürer SC, Oakes SA, Papa FR, Maly DJ. Divergent allosteric control of the IRE1a endoribonuclease using kinase inhibitors. Nat Chem Biol. 2012 Dec; 8(12):982-9. PMID: 23086298; PMCID: PMC3508346.
    5. Lerner AG, Upton JP, Praveen PV, Ghosh R, Nakagawa Y, Igbaria A, Shen S, Nguyen V, Backes BJ, Heiman M, Heintz N, Greengard P, Hui S, Tang Q, Trusina A, Oakes SA, Papa FR. IRE1a induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metab. 2012 Aug 8; 16(2):250-64. PMID: 22883233; PMCID: PMC4014071.
    6. Han D, Lerner AG, Vande Walle L, Upton JP, Xu W, Hagen A, Backes BJ, Oakes SA, Papa FR. IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. Cell. 2009 Aug 7; 138(3):562-75. PMID: 19665977; PMCID: PMC2762408.
    7. Fryer RM, Segreti J, Banfor PN, Widomski DL, Backes BJ, Lin CW, Ballaron SJ, Cox BF, Trevillyan JM, Reinhart GA, von Geldern TW. Effect of bradykinin metabolism inhibitors on evoked hypotension in rats: rank efficacy of enzymes associated with bradykinin-mediated angioedema. Br J Pharmacol. 2008 Mar; 153(5):947-55. PMID: 18084312; PMCID: PMC2267285.
    8. Hamilton GL, Backes BJ. Synthesis of C-11 modified mifepristone analog libraries. Mol Divers. 2007 May; 11(2):107-11. PMID: 17549597.
      View in: PubMed
    9. Pei Z, Li X, von Geldern TW, Longenecker K, Pireh D, Stewart KD, Backes BJ, Lai C, Lubben TH, Ballaron SJ, Beno DW, Kempf-Grote AJ, Sham HL, Trevillyan JM. Discovery and structure-activity relationships of piperidinone- and piperidine-constrained phenethylamines as novel, potent, and selective dipeptidyl peptidase IV inhibitors. J Med Chem. 2007 Apr 19; 50(8):1983-7. PMID: 17367123.
      View in: PubMed
    10. Backes BJ, Longenecker K, Hamilton GL, Stewart K, Lai C, Kopecka H, von Geldern TW, Madar DJ, Pei Z, Lubben TH, Zinker BA, Tian Z, Ballaron SJ, Stashko MA, Mika AK, Beno DW, Kempf-Grote AJ, Black-Schaefer C, Sham HL, Trevillyan JM. Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit. Bioorg Med Chem Lett. 2007 Apr 1; 17(7):2005-12. PMID: 17276063.
      View in: PubMed
    11. Pei Z, Li X, von Geldern TW, Madar DJ, Longenecker K, Yong H, Lubben TH, Stewart KD, Zinker BA, Backes BJ, Judd AS, Mulhern M, Ballaron SJ, Stashko MA, Mika AK, Beno DW, Reinhart GA, Fryer RM, Preusser LC, Kempf-Grote AJ, Sham HL, Trevillyan JM. Discovery of ((4R,5S)-5-amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a highly potent, selective, orally efficacious, and safe dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J Med Chem. 2006 Nov 2; 49(22):6439-42. PMID: 17064063.
      View in: PubMed
    12. Backes BJ, Hamilton GL, Nguyen P, Wilcox D, Fung S, Wang J, Grynfarb M, Goos-Nilsson A, Jacobson PB, von Geldern TW. Parallel strategies for the preparation and selection of liver-targeted glucocorticoid receptor antagonists. Bioorg Med Chem Lett. 2007 Jan 1; 17(1):40-4. PMID: 17070047.
      View in: PubMed
    13. Petrassi HM, Williams JA, Li J, Tumanut C, Ek J, Nakai T, Masick B, Backes BJ, Harris JL. A strategy to profile prime and non-prime proteolytic substrate specificity. Bioorg Med Chem Lett. 2005 Jun 15; 15(12):3162-6. PMID: 15878267.
      View in: PubMed
    14. Isbell JJ, Zhou Y, Guintu C, Rynd M, Jiang S, Petrov D, Micklash K, Mainquist J, Ek J, Chang J, Weselak M, Backes BJ, Brailsford A, Shave D. Purifying the masses: integrating prepurification quality control, high-throughput LC/MS purification, and compound plating to feed high-throughput screening. J Comb Chem. 2005 Mar-Apr; 7(2):210-7. PMID: 15762748.
      View in: PubMed
    15. Shipway A, Danahay H, Williams JA, Tully DC, Backes BJ, Harris JL. Biochemical characterization of prostasin, a channel activating protease. Biochem Biophys Res Commun. 2004 Nov 12; 324(2):953-63. PMID: 15474520.
      View in: PubMed
    16. Harris J, Mason DE, Li J, Burdick KW, Backes BJ, Chen T, Shipway A, Van Heeke G, Gough L, Ghaemmaghami A, Shakib F, Debaene F, Winssinger N. Activity profile of dust mite allergen extract using substrate libraries and functional proteomic microarrays. Chem Biol. 2004 Oct; 11(10):1361-72. PMID: 15489163.
      View in: PubMed
    17. Wang CC, Bozdech Z, Liu CL, Shipway A, Backes BJ, Harris JL, Bogyo M. Biochemical analysis of the 20 S proteasome of Trypanosoma brucei. J Biol Chem. 2003 May 2; 278(18):15800-8. PMID: 12600991.
      View in: PubMed
    18. Maly DJ, Leonetti F, Backes BJ, Dauber DS, Harris JL, Craik CS, Ellman JA. Expedient solid-phase synthesis of fluorogenic protease substrates using the 7-amino-4-carbamoylmethylcoumarin (ACC) fluorophore. J Org Chem. 2002 Feb 8; 67(3):910-5. PMID: 11856036.
      View in: PubMed
    19. Harris JL, Alper PB, Li J, Rechsteiner M, Backes BJ. Substrate specificity of the human proteasome. Chem Biol. 2001 Dec; 8(12):1131-41. PMID: 11755392.
      View in: PubMed
    20. Harris JL, Niles A, Burdick K, Maffitt M, Backes BJ, Ellman JA, Kuntz I, Haak-Frendscho M, Craik CS. Definition of the extended substrate specificity determinants for beta-tryptases I and II. J Biol Chem. 2001 Sep 14; 276(37):34941-7. PMID: 11438529.
      View in: PubMed
    21. Harris JL, Backes BJ, Leonetti F, Mahrus S, Ellman JA, Craik CS. Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries. Proc Natl Acad Sci U S A. 2000 Jul 5; 97(14):7754-9. PMID: 10869434; PMCID: PMC16617.
    22. Backes BJ, Harris JL, Leonetti F, Craik CS, Ellman JA. Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin. Nat Biotechnol. 2000 Feb; 18(2):187-93. PMID: 10657126.
      View in: PubMed
    23. Backes BJ, Ellman JA. Solid support linker strategies. Curr Opin Chem Biol. 1997 Jun; 1(1):86-93. PMID: 9667836.
      View in: PubMed
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