Bradley Backes, PhD

Title(s)Associate Professor, Medicine
SchoolSchool of Medicine
Address1700 4th St, #203B
San Francisco CA 94158
Phone415-502-2185
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    Collapse Research 
    Collapse Research Activities and Funding
    IRE1 alpha inhibitors for Retinal Degenerative Diseases
    NIH R41EY026370Sep 30, 2015 - Sep 29, 2017
    Role: Principal Investigator
    IRE1 alpha inhibitors for type 2 diabetes
    NIH R41DK108377Sep 21, 2015 - Aug 31, 2017
    Role: Principal Investigator
    Developing UPR inhibitory KIRAs into oral antidiabetic beta cell-sparing drugs
    NIH R01DK100623Jan 1, 2014 - Jun 30, 2023
    Role: Co-Principal Investigator
    Inflammasome Inhibitors for Type 2 Diabetes
    NIH R43DK094627Sep 18, 2012 - Aug 31, 2014
    Role: Principal Investigator
    Targeting epithelial cells to treat pulmonary fibrosis
    NIH P01HL108794Aug 9, 2012 - Jul 31, 2018
    Role: Co-Investigator
    Developing UPR Modulators as Novel Therapeutics for Neurodegeneration
    NIH R41NS070401Feb 1, 2011 - Jul 31, 2012
    Role: Principal Investigator
    Cytoprotective Effects of UPR Modulators in ER Stress-Challenged beta-Cells
    NIH R41DK083093Sep 10, 2009 - Dec 31, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2022 04 01; 322(4):L564-L580. Auyeung VC, Downey MS, Thamsen M, Wenger TA, Backes BJ, Sheppard D, Papa FR. PMID: 35170357; PMCID: PMC8957349.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    2. ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR. Nat Chem Biol. 2021 11; 17(11):1148-1156. Feldman HC, Ghosh R, Auyeung VC, Mueller JL, Kim JH, Potter ZE, Vidadala VN, Perera BGK, Olivier A, Backes BJ, Zikherman J, Papa FR, Maly DJ. PMID: 34556859; PMCID: PMC8551014.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    3. A defect in COPI-mediated transport of STING causes immune dysregulation in COPA syndrome. J Exp Med. 2020 11 02; 217(11). Deng Z, Chong Z, Law CS, Mukai K, Ho FO, Martinu T, Backes BJ, Eckalbar WL, Taguchi T, Shum AK. PMID: 32725126; PMCID: PMC7596814.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    4. Targeting Adaptive IRE1α Signaling and PLK2 in Multiple Myeloma: Possible Anti-Tumor Mechanisms of KIRA8 and Nilotinib. Int J Mol Sci. 2020 Aug 31; 21(17). Yamashita Y, Morita S, Hosoi H, Kobata H, Kishimoto S, Ishibashi T, Mishima H, Kinoshita A, Backes BJ, Yoshiura KI, Papa FR, Sonoki T, Tamura S. PMID: 32878237; PMCID: PMC7504392.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    5. Parallel Signaling through IRE1α and PERK Regulates Pancreatic Neuroendocrine Tumor Growth and Survival. Cancer Res. 2019 12 15; 79(24):6190-6203. Moore PC, Qi JY, Thamsen M, Ghosh R, Peng J, Gliedt MJ, Meza-Acevedo R, Warren RE, Hiniker A, Kim GE, Maly DJ, Backes BJ, Papa FR, Oakes SA. PMID: 31672843; PMCID: PMC6911642.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    6. Development of a Chemical Toolset for Studying the Paralog-Specific Function of IRE1. ACS Chem Biol. 2019 12 20; 14(12):2595-2605. Feldman HC, Vidadala VN, Potter ZE, Papa FR, Backes BJ, Maly DJ. PMID: 31609569; PMCID: PMC6925334.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    7. Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung. PLoS One. 2019; 14(1):e0209824. Thamsen M, Ghosh R, Auyeung VC, Brumwell A, Chapman HA, Backes BJ, Perara G, Maly DJ, Sheppard D, Papa FR. PMID: 30625178; PMCID: PMC6326459.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    8. Fibroblast-specific inhibition of TGF-β1 signaling attenuates lung and tumor fibrosis. J Clin Invest. 2017 Oct 02; 127(10):3675-3688. Wei Y, Kim TJ, Peng DH, Duan D, Gibbons DL, Yamauchi M, Jackson JR, Le Saux CJ, Calhoun C, Peters J, Derynck R, Backes BJ, Chapman HA. PMID: 28872461; PMCID: PMC5617667.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    9. Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes. Cell Metab. 2017 05 02; 25(5):1207. Morita S, Villalta SA, Feldman HC, Register AC, Rosenthal W, Hoffmann-Petersen IT, Mehdizadeh M, Ghosh R, Wang L, Colon-Negron K, Meza-Acevedo R, Backes BJ, Maly DJ, Bluestone JA, Papa FR. PMID: 28467938.
      View in: PubMed   Mentions: 17     Fields:    
    10. Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes. Cell Metab. 2017 Apr 04; 25(4):883-897.e8. Morita S, Villalta SA, Feldman HC, Register AC, Rosenthal W, Hoffmann-Petersen IT, Mehdizadeh M, Ghosh R, Wang L, Colon-Negron K, Meza-Acevedo R, Backes BJ, Maly DJ, Bluestone JA, Papa FR. PMID: 28380378; PMCID: PMC5497784.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    11. Structural and Functional Analysis of the Allosteric Inhibition of IRE1α with ATP-Competitive Ligands. ACS Chem Biol. 2016 08 19; 11(8):2195-205. Feldman HC, Tong M, Wang L, Meza-Acevedo R, Gobillot TA, Lebedev I, Gliedt MJ, Hari SB, Mitra AK, Backes BJ, Papa FR, Seeliger MA, Maly DJ. PMID: 27227314; PMCID: PMC4992410.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    12. Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress. Cell. 2014 Jul 31; 158(3):534-48. Ghosh R, Wang L, Wang ES, Perera BG, Igbaria A, Morita S, Prado K, Thamsen M, Caswell D, Macias H, Weiberth KF, Gliedt MJ, Alavi MV, Hari SB, Mitra AK, Bhhatarai B, Schürer SC, Snapp EL, Gould DB, German MS, Backes BJ, Maly DJ, Oakes SA, Papa FR. PMID: 25018104; PMCID: PMC4244221.
      View in: PubMed   Mentions: 240     Fields:    Translation:HumansAnimalsCells
    13. Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors. Nat Chem Biol. 2012 Dec; 8(12):982-9. Wang L, Perera BG, Hari SB, Bhhatarai B, Backes BJ, Seeliger MA, Schürer SC, Oakes SA, Papa FR, Maly DJ. PMID: 23086298; PMCID: PMC3508346.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
    14. IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metab. 2012 Aug 08; 16(2):250-64. Lerner AG, Upton JP, Praveen PV, Ghosh R, Nakagawa Y, Igbaria A, Shen S, Nguyen V, Backes BJ, Heiman M, Heintz N, Greengard P, Hui S, Tang Q, Trusina A, Oakes SA, Papa FR. PMID: 22883233; PMCID: PMC4014071.
      View in: PubMed   Mentions: 408     Fields:    Translation:HumansAnimalsCells
    15. IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. Cell. 2009 Aug 07; 138(3):562-75. Han D, Lerner AG, Vande Walle L, Upton JP, Xu W, Hagen A, Backes BJ, Oakes SA, Papa FR. PMID: 19665977; PMCID: PMC2762408.
      View in: PubMed   Mentions: 445     Fields:    Translation:AnimalsCells
    16. Effect of bradykinin metabolism inhibitors on evoked hypotension in rats: rank efficacy of enzymes associated with bradykinin-mediated angioedema. Br J Pharmacol. 2008 Mar; 153(5):947-55. Fryer RM, Segreti J, Banfor PN, Widomski DL, Backes BJ, Lin CW, Ballaron SJ, Cox BF, Trevillyan JM, Reinhart GA, von Geldern TW. PMID: 18084312; PMCID: PMC2267285.
      View in: PubMed   Mentions: 43     Fields:    Translation:Animals
    17. Synthesis of C-11 modified mifepristone analog libraries. Mol Divers. 2007 May; 11(2):107-11. Hamilton GL, Backes BJ. PMID: 17549597.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    18. Discovery and structure-activity relationships of piperidinone- and piperidine-constrained phenethylamines as novel, potent, and selective dipeptidyl peptidase IV inhibitors. J Med Chem. 2007 Apr 19; 50(8):1983-7. Pei Z, Li X, von Geldern TW, Longenecker K, Pireh D, Stewart KD, Backes BJ, Lai C, Lubben TH, Ballaron SJ, Beno DW, Kempf-Grote AJ, Sham HL, Trevillyan JM. PMID: 17367123.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    19. Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit. Bioorg Med Chem Lett. 2007 Apr 01; 17(7):2005-12. Backes BJ, Longenecker K, Hamilton GL, Stewart K, Lai C, Kopecka H, von Geldern TW, Madar DJ, Pei Z, Lubben TH, Zinker BA, Tian Z, Ballaron SJ, Stashko MA, Mika AK, Beno DW, Kempf-Grote AJ, Black-Schaefer C, Sham HL, Trevillyan JM. PMID: 17276063.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    20. Discovery of ((4R,5S)-5-amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a highly potent, selective, orally efficacious, and safe dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J Med Chem. 2006 Nov 02; 49(22):6439-42. Pei Z, Li X, von Geldern TW, Madar DJ, Longenecker K, Yong H, Lubben TH, Stewart KD, Zinker BA, Backes BJ, Judd AS, Mulhern M, Ballaron SJ, Stashko MA, Mika AK, Beno DW, Reinhart GA, Fryer RM, Preusser LC, Kempf-Grote AJ, Sham HL, Trevillyan JM. PMID: 17064063.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    21. Parallel strategies for the preparation and selection of liver-targeted glucocorticoid receptor antagonists. Bioorg Med Chem Lett. 2007 Jan 01; 17(1):40-4. Backes BJ, Hamilton GL, Nguyen P, Wilcox D, Fung S, Wang J, Grynfarb M, Goos-Nilsson A, Jacobson PB, von Geldern TW. PMID: 17070047.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    22. A strategy to profile prime and non-prime proteolytic substrate specificity. Bioorg Med Chem Lett. 2005 Jun 15; 15(12):3162-6. Petrassi HM, Williams JA, Li J, Tumanut C, Ek J, Nakai T, Masick B, Backes BJ, Harris JL. PMID: 15878267.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    23. Purifying the masses: integrating prepurification quality control, high-throughput LC/MS purification, and compound plating to feed high-throughput screening. J Comb Chem. 2005 Mar-Apr; 7(2):210-7. Isbell JJ, Zhou Y, Guintu C, Rynd M, Jiang S, Petrov D, Micklash K, Mainquist J, Ek J, Chang J, Weselak M, Backes BJ, Brailsford A, Shave D. PMID: 15762748.
      View in: PubMed   Mentions: 1     Fields:    
    24. Biochemical characterization of prostasin, a channel activating protease. Biochem Biophys Res Commun. 2004 Nov 12; 324(2):953-63. Shipway A, Danahay H, Williams JA, Tully DC, Backes BJ, Harris JL. PMID: 15474520.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    25. Activity profile of dust mite allergen extract using substrate libraries and functional proteomic microarrays. Chem Biol. 2004 Oct; 11(10):1361-72. Harris J, Mason DE, Li J, Burdick KW, Backes BJ, Chen T, Shipway A, Van Heeke G, Gough L, Ghaemmaghami A, Shakib F, Debaene F, Winssinger N. PMID: 15489163.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    26. Biochemical analysis of the 20 S proteasome of Trypanosoma brucei. J Biol Chem. 2003 May 02; 278(18):15800-8. Wang CC, Bozdech Z, Liu CL, Shipway A, Backes BJ, Harris JL, Bogyo M. PMID: 12600991.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    27. Expedient solid-phase synthesis of fluorogenic protease substrates using the 7-amino-4-carbamoylmethylcoumarin (ACC) fluorophore. J Org Chem. 2002 Feb 08; 67(3):910-5. Maly DJ, Leonetti F, Backes BJ, Dauber DS, Harris JL, Craik CS, Ellman JA. PMID: 11856036.
      View in: PubMed   Mentions: 46     Fields:    
    28. Substrate specificity of the human proteasome. Chem Biol. 2001 Dec; 8(12):1131-41. Harris JL, Alper PB, Li J, Rechsteiner M, Backes BJ. PMID: 11755392.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    29. From Split-Pool Libraries to Spatially Addressable Microarrays and Its Application to Functional Proteomic Profiling. Angew Chem Int Ed Engl. 2001 Sep 03; 40(17):3152-3155. Winssinger N, Harris JL, Backes BJ, Schultz PG. PMID: 29712061.
      View in: PubMed   Mentions: 4     Fields:    
    30. Definition of the extended substrate specificity determinants for beta-tryptases I and II. J Biol Chem. 2001 Sep 14; 276(37):34941-7. Harris JL, Niles A, Burdick K, Maffitt M, Backes BJ, Ellman JA, Kuntz I, Haak-Frendscho M, Craik CS. PMID: 11438529.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    31. Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries. Proc Natl Acad Sci U S A. 2000 Jul 05; 97(14):7754-9. Harris JL, Backes BJ, Leonetti F, Mahrus S, Ellman JA, Craik CS. PMID: 10869434; PMCID: PMC16617.
      View in: PubMed   Mentions: 165     Fields:    
    32. Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin. Nat Biotechnol. 2000 Feb; 18(2):187-93. Backes BJ, Harris JL, Leonetti F, Craik CS, Ellman JA. PMID: 10657126.
      View in: PubMed   Mentions: 70     Fields:    Translation:Cells
    33. Solid support linker strategies. Curr Opin Chem Biol. 1997 Jun; 1(1):86-93. Backes BJ, Ellman JA. PMID: 9667836.
      View in: PubMed   Mentions: 4     Fields:    
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