Rachel Nosheny, PhD

TitleAssistant Professor
SchoolUCSF School of Medicine
Address4150 Clement St
San Francisco CA 94121
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    Collapse Biography 
    Collapse Education and Training
    University of Pennsylvania, Philadelphia, PABA05/1997Psychology
    Georgetown University, Washington, DCPhD03/2006Neuroscience
    Stanford University, Stanford, CAPostdoctoral Fellowship07/2011Neuroscience

    Collapse Research 
    Collapse Research Activities and Funding
    Implementation and validation of an online Caregiver and Study Partner Portal for assessment of cognitive function in older adults
    NIH/NIA K01AG055692Aug 1, 2017 - Apr 30, 2022
    Role: Principal Investigator
    Gp120-Mediated Cell Death in the Basal Ganglia
    NIH/NINDS F31NS046234Apr 1, 2003 - Mar 31, 2006
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Insel PS, Palmqvist S, Mackin RS, Nosheny R, Hansson O, Weiner MW, Mattsson N. Assessing risk for preclinical ß-amyloid pathology with APOE, cognitive, and demographic information. Alzheimers Dement (Amst). 2016; 4:76-84. PMID: 27722193.
      View in: PubMed
    2. Insel PS, Mattsson N, Mackin RS, Schöll M, Nosheny R, Tosun D, Donohue MC, Aisen PS, Jagust WJ, Weiner MW. Accelerating rates of cognitive decline and imaging markers associated with ß-amyloid pathology. Neurology. 2016 May 17; 86(20):1887-96. PMID: 27164667; PMCID: PMC4873684 [Available on 05/17/17].
    3. Jack CR, Barnes J, Bernstein MA, Borowski BJ, Brewer J, Clegg S, Dale AM, Carmichael O, Ching C, DeCarli C, Desikan RS, Fennema-Notestine C, Fjell AM, Fletcher E, Fox NC, Gunter J, Gutman BA, Holland D, Hua X, Insel P, Kantarci K, Killiany RJ, Krueger G, Leung KK, Mackin S, Maillard P, Malone IB, Mattsson N, McEvoy L, Modat M, Mueller S, Nosheny R, Ourselin S, Schuff N, Senjem ML, Simonson A, Thompson PM, Rettmann D, Vemuri P, Walhovd K, Zhao Y, Zuk S, Weiner M. Magnetic resonance imaging in Alzheimer's Disease Neuroimaging Initiative 2. Alzheimers Dement. 2015 Jul; 11(7):740-56. PMID: 26194310; PMCID: PMC4523217.
    4. Insel PS, Mattsson N, Mackin RS, Kornak J, Nosheny R, Tosun-Turgut D, Donohue MC, Aisen PS, Weiner MW. Biomarkers and cognitive endpoints to optimize trials in Alzheimer's disease. Ann Clin Transl Neurol. 2015 May; 2(5):534-47. PMID: 26000325; PMCID: PMC4435707.
    5. Nosheny R, Belichenko PV, Busse BL, Weissmiller AM, Dang V, Das D, Fahimi A, Salehi A, Smith SJ, Mobley WC. Increased cortical synaptic activation of TrkB and downstream signaling markers in a mouse model of Down Syndrome. Neurobiol Dis. 2015 May; 77:173-90. PMID: 25753471.
      View in: PubMed
    6. Nosheny R, Insel PS, Truran D, Schuff N, Jack CR, Aisen PS, Shaw LM, Trojanowski JQ, Weiner MW. Variables associated with hippocampal atrophy rate in normal aging and mild cognitive impairment. Neurobiol Aging. 2015 Jan; 36(1):273-82. PMID: 25175807.
      View in: PubMed
    7. Mattsson N, Insel PS, Nosheny R, Tosun D, Trojanowski JQ, Shaw LM, Jack CR, Donohue MC, Weiner MW. Emerging ß-amyloid pathology and accelerated cortical atrophy. JAMA Neurol. 2014 Jun; 71(6):725-34. PMID: 24781145; PMCID: PMC4410966.
    8. Mattsson N, Insel P, Nosheny R, Trojanowski JQ, Shaw LM, Jack CR, Tosun D, Weiner M. Effects of cerebrospinal fluid proteins on brain atrophy rates in cognitively healthy older adults. Neurobiol Aging. 2014 Mar; 35(3):614-22. PMID: 24094581; PMCID: PMC3864623.
    9. Mattsson N, Insel P, Nosheny R, Zetterberg H, Trojanowski JQ, Shaw LM, Tosun D, Weiner M. CSF protein biomarkers predicting longitudinal reduction of CSF ß-amyloid42 in cognitively healthy elders. Transl Psychiatry. 2013 Aug 20; 3:e293. PMID: 23962923; PMCID: PMC3756294.
    10. Dang V, Medina B, Das D, Moghadam S, Martin KJ, Lin B, Naik P, Patel D, Nosheny R, Wesson Ashford J, Salehi A. Formoterol, a long-acting ß2 adrenergic agonist, improves cognitive function and promotes dendritic complexity in a mouse model of Down syndrome. Biol Psychiatry. 2014 Feb 1; 75(3):179-88. PMID: 23827853.
      View in: PubMed
    11. Kleschevnikov AM, Belichenko PV, Gall J, George L, Nosheny R, Maloney MT, Salehi A, Mobley WC. Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome. Neurobiol Dis. 2012 Feb; 45(2):683-91. PMID: 22062771; PMCID: PMC3259223.
    12. Bachis A, Cruz MI, Nosheny R, Mocchetti I. Chronic unpredictable stress promotes neuronal apoptosis in the cerebral cortex. Neurosci Lett. 2008 Sep 12; 442(2):104-8. PMID: 18621098; PMCID: PMC2543936.
    13. Mocchetti I, Nosheny R, Tanda G, Ren K, Meyer EM. Brain-derived neurotrophic factor prevents human immunodeficiency virus type 1 protein gp120 neurotoxicity in the rat nigrostriatal system. Ann N Y Acad Sci. 2007 Dec; 1122:144-54. PMID: 18077570.
      View in: PubMed
    14. Mocchetti I, Bachis A, Nosheny R, Tanda G. Brain-derived neurotrophic factor expression in the substantia nigra does not change after lesions of dopaminergic neurons. Neurotox Res. 2007 Sep; 12(2):135-43. PMID: 17967737.
      View in: PubMed
    15. Nosheny R, Ahmed F, Yakovlev A, Meyer EM, Ren K, Tessarollo L, Mocchetti I. Brain-derived neurotrophic factor prevents the nigrostriatal degeneration induced by human immunodeficiency virus-1 glycoprotein 120 in vivo. Eur J Neurosci. 2007 Apr; 25(8):2275-84. PMID: 17445226.
      View in: PubMed
    16. Nosheny R, Bachis A, Aden SA, De Bernardi MA, Mocchetti I. Intrastriatal administration of human immunodeficiency virus-1 glycoprotein 120 reduces glial cell-line derived neurotrophic factor levels and causes apoptosis in the substantia nigra. J Neurobiol. 2006 Oct; 66(12):1311-21. PMID: 16967504.
      View in: PubMed
    17. Bachis A, Aden SA, Nosheny R, Andrews PM, Mocchetti I. Axonal transport of human immunodeficiency virus type 1 envelope protein glycoprotein 120 is found in association with neuronal apoptosis. J Neurosci. 2006 Jun 21; 26(25):6771-80. PMID: 16793884.
      View in: PubMed
    18. Nosheny R, Mocchetti I, Bachis A. Brain-derived neurotrophic factor as a prototype neuroprotective factor against HIV-1-associated neuronal degeneration. Neurotox Res. 2005 Oct; 8(1-2):187-98. PMID: 16260395.
      View in: PubMed
    19. Nosheny R, Bachis A, Acquas E, Mocchetti I. Human immunodeficiency virus type 1 glycoprotein gp120 reduces the levels of brain-derived neurotrophic factor in vivo: potential implication for neuronal cell death. Eur J Neurosci. 2004 Dec; 20(11):2857-64. PMID: 15579139.
      View in: PubMed
    20. Acquas E, Bachis A, Nosheny R, Cernak I, Mocchetti I. Human immunodeficiency virus type 1 protein gp120 causes neuronal cell death in the rat brain by activating caspases. Neurotox Res. 2004; 5(8):605-15. PMID: 15111237.
      View in: PubMed
    21. Belles C, Kuhl A, Nosheny R, Carding SR. Plasma membrane expression of heat shock protein 60 in vivo in response to infection. Infect Immun. 1999 Aug; 67(8):4191-200. PMID: 10417191; PMCID: PMC96724.
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