 Sam Hawgood
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| Title | Dean |
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| School | UCSF School of Medicine |
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| Department | School of Medicine Dean's Office |
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| Address | 513 Parnassus Ave, Med Sci
San Francisco CA 94143
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| Phone | 415-476-2342 |
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| Title | Vice Chancellor Medical Affairs, UCSF |
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| Title | Professor, School of Medicine |
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 Biography | Institute of Medicine | 2010 | | Member | | UCSF Medical Center | 2009 | | Exceptional Physician Award | | Oxford University, England | 2008 | | Sir Peter Tizzard Memorial Lecture | | Society for Pediatric Research | 2005 | | Distinguished Service Award |
Overview Sam Hawgood, MBBS, was appointed dean of the UCSF School of Medicine and vice chancellor for medical affairs in September of 2009, after having served as interim dean since December of 2007. In addition to his distinguished career at UCSF, where he was chair of the Department of Pediatrics and associate director of the Cardiovascular Research Institute, he has an international reputation in neonatology research.
Hawgood, a native of Australia, graduated medical school with First Class Honors from the University of Queensland in Brisbane. He trained in pediatrics as a resident, followed by specialization in neonatology as a fellow.
As a clinician, he witnessed the tragic deaths of infants from respiratory distress syndrome (RDS), a developmental deficiency of pulmonary surfactant and a major cause of neonatal death. Hawgood’s quest to prevent RDS led him to UCSF, where he worked as a research fellow with the distinguished scientists John Clements and William Tooley, pioneers in the discovery and therapeutic uses of pulmonary surfactant in premature babies.
He started his own laboratory in 1984, which is focused on the proteins associated with pulmonary surfactant. A multi-disciplinary Program Project Grant from the National Heart, Lung and Blood Institute has supported his work continuously since then. His scientific contributions over the last decades have been recognized by numerous awards, publications and invitations to present in national and international forums. He is a member of the American Academy of Pediatrics, and was elected in 2010 to the Institute of Medicine (IOM), part of the National Academy of Sciences.
Hawgood has maintained an active presence in clinical medicine since serving first as division chief of Neonatology, then as chair of Pediatrics and physician-in-chief of the UCSF Benioff Children’s Hospital. He is the president of the UCSF Medical Group, the faculty plan that represents more than 1,000 physicians at UCSF.
As dean of the School of Medicine, he is responsible for an organization with nearly 15,000 employees, around 3,500 medical and graduate students, residents, fellows and postdoctoral scholars, and an operating budget of over $1.5 billion. He leads the school’s mission to advance human health through education, research, patient care and public service.
Bibliographic
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O'Brien T, Yamamoto K, Hawgood S. Commentary: team science. Acad Med. 2013 Feb; 88(2):156-7.
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Montalbano AP, Hawgood S, Mendelson CR. Mice Deficient in Surfactant Protein A (SP-A) and SP-D or in TLR2 Manifest Delayed Parturition and Decreased Expression of Inflammatory and Contractile Genes. Endocrinology. 2013 Jan; 154(1):483-98.
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Stidsen JV, Khorooshi R, Rahbek MK, Kirketerp-Møller KL, Hansen PB, Bie P, Kejling K, Mandrup S, Hawgood S, Nielsen O, Nielsen CH, Owens T, Holmskov U, Sørensen GL. Surfactant protein d deficiency in mice is associated with hyperphagia, altered fat deposition, insulin resistance, and increased basal endotoxemia. PLoS One. 2012; 7(4):e35066.
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Keller RL, Tacy TA, Hendricks-Munoz K, Xu J, Moon-Grady AJ, Neuhaus J, Moore P, Nobuhara KK, Hawgood S, Fineman JR. Congenital diaphragmatic hernia: endothelin-1, pulmonary hypertension, and disease severity. Am J Respir Crit Care Med. 2010 Aug 15; 182(4):555-61.
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Madan T, Reid KB, Clark H, Singh M, Nayak A, Sarma PU, Hawgood S, Kishore U. Susceptibility of mice genetically deficient in SP-A or SP-D gene to invasive pulmonary aspergillosis. Mol Immunol. 2010 Jun; 47(10):1923-30.
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Mun JJ, Tam C, Kowbel D, Hawgood S, Barnett MJ, Evans DJ, Fleiszig SM. Clearance of Pseudomonas aeruginosa from a healthy ocular surface involves surfactant protein D and is compromised by bacterial elastase in a murine null-infection model. Infect Immun. 2009 Jun; 77(6):2392-8.
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Knudsen L, Wucherpfennig K, Mackay RM, Townsend P, Mühlfeld C, Richter J, Hawgood S, Reid K, Clark H, Ochs M. A recombinant fragment of human surfactant protein D lacking the short collagen-like stalk fails to correct morphological alterations in lungs of SP-D deficient mice. Anat Rec (Hoboken). 2009 Feb; 292(2):183-9.
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Gram K, Yang S, Steiner M, Somani A, Hawgood S, Blazar BR, Panoskaltsis-Mortari A, Haddad IY. Simultaneous absence of surfactant proteins A and D increases lung inflammation and injury after allogeneic HSCT in mice. Am J Physiol Lung Cell Mol Physiol. 2009 Feb; 296(2):L167-75.
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Ni M, Tam C, Verma A, Ramphal R, Hawgood S, Evans DJ, Fleiszig SM. Expression of surfactant protein D in human corneal epithelial cells is upregulated by Pseudomonas aeruginosa. FEMS Immunol Med Microbiol. 2008 Nov; 54(2):177-84.
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Wagner AJ, Stumbaugh A, Tigue Z, Edmondson J, Paquet AC, Farmer DL, Hawgood S. Genetic analysis of congenital cystic adenomatoid malformation reveals a novel pulmonary gene: fatty acid binding protein-7 (brain type). Pediatr Res. 2008 Jul; 64(1):11-6.
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Jancelewicz T, Nobuhara K, Hawgood S. Laser microdissection allows detection of abnormal gene expression in cystic adenomatoid malformation of the lung. J Pediatr Surg. 2008 Jun; 43(6):1044-51.
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Knudsen L, Ochs M, Mackay R, Townsend P, Deb R, Mühlfeld C, Richter J, Gilbert F, Hawgood S, Reid K, Clark H. Truncated recombinant human SP-D attenuates emphysema and type II cell changes in SP-D deficient mice. Respir Res. 2007; 8:70.
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Koth LL, Alex B, Hawgood S, Nead MA, Sheppard D, Erle DJ, Morris DG. Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1. Am J Respir Cell Mol Biol. 2007 Dec; 37(6):651-9.
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Vigerust DJ, Ulett KB, Boyd KL, Madsen J, Hawgood S, McCullers JA. N-linked glycosylation attenuates H3N2 influenza viruses. J Virol. 2007 Aug; 81(16):8593-600.
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Khamri W, Worku ML, Anderson AE, Walker MM, Hawgood S, Reid KB, Clark HW, Thursz MR. Helicobacter infection in the surfactant protein D-deficient mouse. Helicobacter. 2007 Apr; 12(2):112-23.
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Haque R, Umstead TM, Ponnuru P, Guo X, Hawgood S, Phelps DS, Floros J. Role of surfactant protein-A (SP-A) in lung injury in response to acute ozone exposure of SP-A deficient mice. Toxicol Appl Pharmacol. 2007 Apr 1; 220(1):72-82.
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Sorensen GL, Hjelmborg JV, Leth-Larsen R, Schmidt V, Fenger M, Poulain F, Hawgood S, Sørensen TI, Kyvik KO, Holmskov U. Surfactant protein D of the innate immune defence is inversely associated with human obesity and SP-D deficiency infers increased body weight in mice. Scand J Immunol. 2006 Dec; 64(6):633-8.
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Keller RL, Moore P, Teitel D, Hawgood S, McQuitty J, Fineman JR. Abnormal vascular tone in infants and children with lung hypoplasia: Findings from cardiac catheterization and the response to chronic therapy. Pediatr Crit Care Med. 2006 Nov; 7(6):589-94.
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Baldán A, Tarr P, Vales CS, Frank J, Shimotake TK, Hawgood S, Edwards PA. Deletion of the transmembrane transporter ABCG1 results in progressive pulmonary lipidosis. J Biol Chem. 2006 Sep 29; 281(39):29401-10.
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Haczku A, Cao Y, Vass G, Kierstein S, Nath P, Atochina-Vasserman EN, Scanlon ST, Li L, Griswold DE, Chung KF, Poulain FR, Hawgood S, Beers MF, Crouch EC. IL-4 and IL-13 form a negative feedback circuit with surfactant protein-D in the allergic airway response. J Immunol. 2006 Mar 15; 176(6):3557-65.
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Jegatheesan P, Keller RL, Hawgood S. Early variable-flow nasal continuous positive airway pressure in infants < or =1000 grams at birth. J Perinatol. 2006 Mar; 26(3):189-96.
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Giannoni E, Sawa T, Allen L, Wiener-Kronish J, Hawgood S. Surfactant proteins A and D enhance pulmonary clearance of Pseudomonas aeruginosa. Am J Respir Cell Mol Biol. 2006 Jun; 34(6):704-10.
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Sorensen GL, Madsen J, Kejling K, Tornoe I, Nielsen O, Townsend P, Poulain F, Nielsen CH, Reid KB, Hawgood S, Falk E, Holmskov U. Surfactant protein D is proatherogenic in mice. Am J Physiol Heart Circ Physiol. 2006 Jun; 290(6):H2286-94.
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Jounblat R, Clark H, Eggleton P, Hawgood S, Andrew PW, Kadioglu A. The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia. Respir Res. 2005; 6:126.
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Xu X, Zhang D, Lyubynska N, Wolters PJ, Killeen NP, Baluk P, McDonald DM, Hawgood S, Caughey GH. Mast cells protect mice from Mycoplasma pneumonia. Am J Respir Crit Care Med. 2006 Jan 15; 173(2):219-25.
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Jung A, Allen L, Nyengaard JR, Gundersen HJ, Richter J, Hawgood S, Ochs M. Design-based stereological analysis of the lung parenchymal architecture and alveolar type II cells in surfactant protein A and D double deficient mice. Anat Rec A Discov Mol Cell Evol Biol. 2005 Oct; 286(2):885-90.
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Casey J, Kaplan J, Atochina-Vasserman EN, Gow AJ, Kadire H, Tomer Y, Fisher JH, Hawgood S, Savani RC, Beers MF. Alveolar surfactant protein D content modulates bleomycin-induced lung injury. Am J Respir Crit Care Med. 2005 Oct 1; 172(7):869-77.
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Palaniyar N, Clark H, Nadesalingam J, Shih MJ, Hawgood S, Reid KB. Innate immune collectin surfactant protein D enhances the clearance of DNA by macrophages and minimizes anti-DNA antibody generation. J Immunol. 2005 Jun 1; 174(11):7352-8.
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Ni M, Evans DJ, Hawgood S, Anders EM, Sack RA, Fleiszig SM. Surfactant protein D is present in human tear fluid and the cornea and inhibits epithelial cell invasion by Pseudomonas aeruginosa. Infect Immun. 2005 Apr; 73(4):2147-56.
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Schaub B, Westlake RM, He H, Arestides R, Haley KJ, Campo M, Velasco G, Bellou A, Hawgood S, Poulain FR, Perkins DL, Finn PW. Surfactant protein D deficiency influences allergic immune responses. Clin Exp Allergy. 2004 Dec; 34(12):1819-26.
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Atochina EN, Beck JM, Preston AM, Haczku A, Tomer Y, Scanlon ST, Fusaro T, Casey J, Hawgood S, Gow AJ, Beers MF. Enhanced lung injury and delayed clearance of Pneumocystis carinii in surfactant protein A-deficient mice: attenuation of cytokine responses and reactive oxygen-nitrogen species. Infect Immun. 2004 Oct; 72(10):6002-11.
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Brasch F, Birzele J, Ochs M, Guttentag SH, Schoch OD, Boehler A, Beers MF, Müller KM, Hawgood S, Johnen G. Surfactant proteins in pulmonary alveolar proteinosis in adults. Eur Respir J. 2004 Sep; 24(3):426-35.
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Keller RL, Hawgood S, Neuhaus JM, Farmer DL, Lee H, Albanese CT, Harrison MR, Kitterman JA. Infant pulmonary function in a randomized trial of fetal tracheal occlusion for severe congenital diaphragmatic hernia. Pediatr Res. 2004 Nov; 56(5):818-25.
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Ochs M, Knudsen L, Allen L, Stumbaugh A, Levitt S, Nyengaard JR, Hawgood S. GM-CSF mediates alveolar epithelial type II cell changes, but not emphysema-like pathology, in SP-D-deficient mice. Am J Physiol Lung Cell Mol Physiol. 2004 Dec; 287(6):L1333-41.
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Hawgood S, Brown C, Edmondson J, Stumbaugh A, Allen L, Goerke J, Clark H, Poulain F. Pulmonary collectins modulate strain-specific influenza a virus infection and host responses. J Virol. 2004 Aug; 78(16):8565-72.
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Hawgood S. Surfactant protein B: structure and function. Biol Neonate. 2004; 85(4):285-9.
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Atochina EN, Gow AJ, Beck JM, Haczku A, Inch A, Kadire H, Tomer Y, Davis C, Preston AM, Poulain F, Hawgood S, Beers MF. Delayed clearance of pneumocystis carinii infection, increased inflammation, and altered nitric oxide metabolism in lungs of surfactant protein-D knockout mice. J Infect Dis. 2004 Apr 15; 189(8):1528-39.
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Keller RL, Hamrick SE, Kitterman JA, Fineman JR, Hawgood S. Treatment of rebound and chronic pulmonary hypertension with oral sildenafil in an infant with congenital diaphragmatic hernia. Pediatr Crit Care Med. 2004 Mar; 5(2):184-7.
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Clark H, Palaniyar N, Hawgood S, Reid KB. A recombinant fragment of human surfactant protein D reduces alveolar macrophage apoptosis and pro-inflammatory cytokines in mice developing pulmonary emphysema. Ann N Y Acad Sci. 2003 Dec; 1010:113-6.
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Palaniyar N, Clark H, Nadesalingam J, Hawgood S, Reid KB. Surfactant protein D binds genomic DNA and apoptotic cells, and enhances their clearance, in vivo. Ann N Y Acad Sci. 2003 Dec; 1010:471-5.
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Harrison MR, Keller RL, Hawgood SB, Kitterman JA, Sandberg PL, Farmer DL, Lee H, Filly RA, Farrell JA, Albanese CT. A randomized trial of fetal endoscopic tracheal occlusion for severe fetal congenital diaphragmatic hernia. N Engl J Med. 2003 Nov 13; 349(20):1916-24.
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Brasch F, Ochs M, Kahne T, Guttentag S, Schauer-Vukasinovic V, Derrick M, Johnen G, Kapp N, Muller KM, Richter J, Giller T, Hawgood S, Buhling F. Involvement of napsin A in the C- and N-terminal processing of surfactant protein B in type-II pneumocytes of the human lung. J Biol Chem. 2003 Dec 5; 278(49):49006-14.
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Brasch F, Johnen G, Winn-Brasch A, Guttentag SH, Schmiedl A, Kapp N, Suzuki Y, Müller KM, Richter J, Hawgood S, Ochs M. Surfactant protein B in type II pneumocytes and intra-alveolar surfactant forms of human lungs. Am J Respir Cell Mol Biol. 2004 Apr; 30(4):449-58.
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Atochina EN, Beers MF, Hawgood S, Poulain F, Davis C, Fusaro T, Gow AJ. Surfactant protein-D, a mediator of innate lung immunity, alters the products of nitric oxide metabolism. Am J Respir Cell Mol Biol. 2004 Mar; 30(3):271-9.
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Hamrick SE, Gremmels DB, Keet CA, Leonard CH, Connell JK, Hawgood S, Piecuch RE. Neurodevelopmental outcome of infants supported with extracorporeal membrane oxygenation after cardiac surgery. Pediatrics. 2003 Jun; 111(6 Pt 1):e671-5.
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Haddad IY, Milla C, Yang S, Panoskaltsis-Mortari A, Hawgood S, Lacey DL, Blazar BR. Surfactant protein A is a required mediator of keratinocyte growth factor after experimental marrow transplantation. Am J Physiol Lung Cell Mol Physiol. 2003 Sep; 285(3):L602-10.
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Tsao K, Hawgood S, Vu L, Hirose S, Sydorak R, Albanese CT, Farmer DL, Harrison MR, Lee H. Resolution of hydrops fetalis in congenital cystic adenomatoid malformation after prenatal steroid therapy. J Pediatr Surg. 2003 Mar; 38(3):508-10.
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Keller RL, Aaroz PA, Hawgood S, Higgins CB. MR imaging of hepatic pulmonary fusion in neonates. AJR Am J Roentgenol. 2003 Feb; 180(2):438-40.
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Jain D, Dodia C, Bates SR, Hawgood S, Poulain FR, Fisher AB. SP-A is necessary for increased clearance of alveolar DPPC with hyperventilation or secretagogues. Am J Physiol Lung Cell Mol Physiol. 2003 May; 284(5):L759-65.
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Hawgood S, Ochs M, Jung A, Akiyama J, Allen L, Brown C, Edmondson J, Levitt S, Carlson E, Gillespie AM, Villar A, Epstein CJ, Poulain FR. Sequential targeted deficiency of SP-A and -D leads to progressive alveolar lipoproteinosis and emphysema. Am J Physiol Lung Cell Mol Physiol. 2002 Nov; 283(5):L1002-10.
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Clark H, Palaniyar N, Strong P, Edmondson J, Hawgood S, Reid KB. Surfactant protein D reduces alveolar macrophage apoptosis in vivo. J Immunol. 2002 Sep 15; 169(6):2892-9.
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Yang S, Milla C, Panoskaltsis-Mortari A, Hawgood S, Blazar BR, Haddad IY. Surfactant protein A decreases lung injury and mortality after murine marrow transplantation. Am J Respir Cell Mol Biol. 2002 Sep; 27(3):297-305.
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Akiyama J, Hoffman A, Brown C, Allen L, Edmondson J, Poulain F, Hawgood S. Tissue distribution of surfactant proteins A and D in the mouse. J Histochem Cytochem. 2002 Jul; 50(7):993-6.
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Li G, Siddiqui J, Hendry M, Akiyama J, Edmondson J, Brown C, Allen L, Levitt S, Poulain F, Hawgood S. Surfactant protein-A--deficient mice display an exaggerated early inflammatory response to a beta-resistant strain of influenza A virus. Am J Respir Cell Mol Biol. 2002 Mar; 26(3):277-82.
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Ochs M, Johnen G, Müller KM, Wahlers T, Hawgood S, Richter J, Brasch F. Intracellular and intraalveolar localization of surfactant protein A (SP-A) in the parenchymal region of the human lung. Am J Respir Cell Mol Biol. 2002 Jan; 26(1):91-8.
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Harrison MR, Albanese CT, Hawgood SB, Farmer DL, Farrell JA, Sandberg PL, Filly RA. Fetoscopic temporary tracheal occlusion by means of detachable balloon for congenital diaphragmatic hernia. Am J Obstet Gynecol. 2001 Sep; 185(3):730-3.
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Hawgood S, Akiyama J, Brown C, Allen L, Li G, Poulain FR. GM-CSF mediates alveolar macrophage proliferation and type II cell hypertrophy in SP-D gene-targeted mice. Am J Physiol Lung Cell Mol Physiol. 2001 Jun; 280(6):L1148-56.
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Tworetzky W, Bristow J, Moore P, Brook MM, Segal MR, Brasch RC, Hawgood S, Fineman JR. Inhaled nitric oxide in neonates with persistent pulmonary hypertension. Lancet. 2001 Jan 13; 357(9250):118-20.
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Hawgood S, Poulain FR. The pulmonary collectins and surfactant metabolism. Annu Rev Physiol. 2001; 63:495-519.
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Akiyama J, Volik SV, Plajzer-Frick I, Prince A, Sago H, Weier HU, Vanderbilt JN, Hawgood S, Poulain FR. Characterization of the mouse collectin gene locus. Am J Respir Cell Mol Biol. 1999 Aug; 21(2):193-9.
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Poulain FR, Akiyama J, Allen L, Brown C, Chang R, Goerke J, Dobbs L, Hawgood S. Ultrastructure of phospholipid mixtures reconstituted with surfactant proteins B and D. Am J Respir Cell Mol Biol. 1999 May; 20(5):1049-58.
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Clark H, Allen L, Collins E, Barr F, Dobbs L, Putz G, Goerke J, Hawgood S. Localization of a candidate surfactant convertase to type II cells, macrophages, and surfactant subfractions. Am J Physiol. 1999 Mar; 276(3 Pt 1):L452-8.
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Hawgood S, Derrick M, Poulain F. Structure and properties of surfactant protein B. Biochim Biophys Acta. 1998 Nov 19; 1408(2-3):150-60.
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Botas C, Poulain F, Akiyama J, Brown C, Allen L, Goerke J, Clements J, Carlson E, Gillespie AM, Epstein C, Hawgood S. Altered surfactant homeostasis and alveolar type II cell morphology in mice lacking surfactant protein D. Proc Natl Acad Sci U S A. 1998 Sep 29; 95(20):11869-74.
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Harrison MR, Mychaliska GB, Albanese CT, Jennings RW, Farrell JA, Hawgood S, Sandberg P, Levine AH, Lobo E, Filly RA. Correction of congenital diaphragmatic hernia in utero IX: fetuses with poor prognosis (liver herniation and low lung-to-head ratio) can be saved by fetoscopic temporary tracheal occlusion. J Pediatr Surg. 1998 Jul; 33(7):1017-22; discussion 1022-3.
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Chi X, Garnier G, Hawgood S, Colten HR. Identification of a novel alternatively spliced mRNA of murine pulmonary surfactant protein B. Am J Respir Cell Mol Biol. 1998 Jul; 19(1):107-13.
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Barr F, Clark H, Hawgood S. Identification of a putative surfactant convertase in rat lung as a secreted serine carboxylesterase. Am J Physiol. 1998 Mar; 274(3 Pt 1):L404-10.
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Hawgood S. Surfactant protein genes and human disease: the plot thickens. J Pediatr. 1998 Feb; 132(2):198-200.
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Bullard KM, Sonne J, Hawgood S, Harrison MR, Adzick NS. Tracheal ligation increases cell proliferation but decreases surfactant protein in fetal murine lungs in vitro. J Pediatr Surg. 1997 Feb; 32(2):207-11; discussion 211-3.
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Joe P, Wallen LD, Chapin CJ, Lee CH, Allen L, Han VK, Dobbs LG, Hawgood S, Kitterman JA. Effects of mechanical factors on growth and maturation of the lung in fetal sheep. Am J Physiol. 1997 Jan; 272(1 Pt 1):L95-105.
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Hawgood S, Ogawa A, Yukitake K, Schlueter M, Brown C, White T, Buckley D, Lesikar D, Benson B. Lung function in premature rabbits treated with recombinant human surfactant protein-C. Am J Respir Crit Care Med. 1996 Aug; 154(2 Pt 1):484-90.
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Wong CJ, Akiyama J, Allen L, Hawgood S. Localization and developmental expression of surfactant proteins D and A in the respiratory tract of the mouse. Pediatr Res. 1996 Jun; 39(6):930-7.
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Poulain FR, Nir S, Hawgood S. Kinetics of phospholipid membrane fusion induced by surfactant apoproteins A and B. Biochim Biophys Acta. 1996 Jan 31; 1278(2):169-75.
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Pinto RA, Hawgood S, Clements JA, Benson BJ, Naidu A, Hamilton RL, Wright JR. Association of surfactant protein C with isolated alveolar type II cells. Biochim Biophys Acta. 1995 Mar 2; 1255(1):16-22.
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Hawgood S, Poulain FR. Functions of the surfactant proteins: a perspective. Pediatr Pulmonol. 1995 Feb; 19(2):99-104.
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Yukitake K, Brown CL, Schlueter MA, Clements JA, Hawgood S. Surfactant apoprotein A modifies the inhibitory effect of plasma proteins on surfactant activity in vivo. Pediatr Res. 1995 Jan; 37(1):21-5.
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Ogawa A, Brown CL, Schlueter MA, Benson BJ, Clements JA, Hawgood S. Lung function, surfactant apoprotein content, and level of PEEP in prematurely delivered rabbits. J Appl Physiol. 1994 Oct; 77(4):1840-9.
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Sullivan KM, Hawgood S, Flake AW, Harrison MR, Adzick NS. Amniotic fluid phospholipid analysis in the fetus with congenital diaphragmatic hernia. J Pediatr Surg. 1994 Aug; 29(8):1020-3; discussion 1023-4.
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Hawgood S, Latham D, Borchelt J, Damm D, White T, Benson B, Wright JR. Cell-specific posttranslational processing of the surfactant-associated protein SP-B. Am J Physiol. 1993 Mar; 264(3 Pt 1):L290-9.
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Shiffer K, Hawgood S, Haagsman HP, Benson B, Clements JA, Goerke J. Lung surfactant proteins, SP-B and SP-C, alter the thermodynamic properties of phospholipid membranes: a differential calorimetry study. Biochemistry. 1993 Jan 19; 32(2):590-7.
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Pison U, Obertacke U, Seeger W, Hawgood S. Surfactant protein A (SP-A) is decreased in acute parenchymal lung injury associated with polytrauma. Eur J Clin Invest. 1992 Nov; 22(11):712-8.
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Poulain FR, Allen L, Williams MC, Hamilton RL, Hawgood S. Effects of surfactant apolipoproteins on liposome structure: implications for tubular myelin formation. Am J Physiol. 1992 Jun; 262(6 Pt 1):L730-9.
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Pison U, Wright JR, Hawgood S. Specific binding of surfactant apoprotein SP-A to rat alveolar macrophages. Am J Physiol. 1992 Apr; 262(4 Pt 1):L412-7.
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Williams MC, Hawgood S, Hamilton RL. Changes in lipid structure produced by surfactant proteins SP-A, SP-B, and SP-C. Am J Respir Cell Mol Biol. 1991 Jul; 5(1):41-50.
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Hawgood S, Shiffer K. Structures and properties of the surfactant-associated proteins. Annu Rev Physiol. 1991; 53:375-94.
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Haagsman HP, Sargeant T, Hauschka PV, Benson BJ, Hawgood S. Binding of calcium to SP-A, a surfactant-associated protein. Biochemistry. 1990 Sep 25; 29(38):8894-900.
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Hawgood S, Clements JA. Pulmonary surfactant and its apoproteins. J Clin Invest. 1990 Jul; 86(1):1-6.
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Haagsman HP, White RT, Schilling J, Lau K, Benson BJ, Golden J, Hawgood S, Clements JA. Studies of the structure of lung surfactant protein SP-A. Am J Physiol. 1989 Dec; 257(6 Pt 1):L421-9.
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Pison U, Tam EK, Caughey GH, Hawgood S. Proteolytic inactivation of dog lung surfactant-associated proteins by neutrophil elastase. Biochim Biophys Acta. 1989 Sep 15; 992(3):251-7.
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Hawgood S. Pulmonary surfactant apoproteins: a review of protein and genomic structure. Am J Physiol. 1989 Aug; 257(2 Pt 1):L13-22.
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Wright JR, Borchelt JD, Hawgood S. Lung surfactant apoprotein SP-A (26-36 kDa) binds with high affinity to isolated alveolar type II cells. Proc Natl Acad Sci U S A. 1989 Jul; 86(14):5410-4.
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Liley HG, White RT, Warr RG, Benson BJ, Hawgood S, Ballard PL. Regulation of messenger RNAs for the hydrophobic surfactant proteins in human lung. J Clin Invest. 1989 Apr; 83(4):1191-7.
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Wright JR, Hawgood S. Pulmonary surfactant metabolism. Clin Chest Med. 1989 Mar; 10(1):83-93.
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Liley HG, Ertsey R, Gonzales LW, Odom MW, Hawgood S, Dobbs LG, Ballard PL. Synthesis of surfactant components by cultured type II cells from human lung. Biochim Biophys Acta. 1988 Jul 1; 961(1):86-95.
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Shiffer K, Hawgood S, Düzgünes N, Goerke J. Interactions of the low molecular weight group of surfactant-associated proteins (SP 5-18) with pulmonary surfactant lipids. Biochemistry. 1988 Apr 19; 27(8):2689-95.
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Williams MC, Hawgood S, Schenk DB, Lewicki J, Phelps MN, Benson B. Monoclonal antibodies to surfactant proteins SP28-36 label canine type II and nonciliated bronchiolar cells by immunofluorescence. Am Rev Respir Dis. 1988 Feb; 137(2):399-405.
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Efrati H, Hawgood S, Williams MC, Hong K, Benson BJ. Divalent cation and hydrogen ion effects on the structure and surface activity of pulmonary surfactant. Biochemistry. 1987 Dec 1; 26(24):7986-93.
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Warr RG, Hawgood S, Buckley DI, Crisp TM, Schilling J, Benson BJ, Ballard PL, Clements JA, White RT. Low molecular weight human pulmonary surfactant protein (SP5): isolation, characterization, and cDNA and amino acid sequences. Proc Natl Acad Sci U S A. 1987 Nov; 84(22):7915-9.
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Haagsman HP, Hawgood S, Sargeant T, Buckley D, White RT, Drickamer K, Benson BJ. The major lung surfactant protein, SP 28-36, is a calcium-dependent, carbohydrate-binding protein. J Biol Chem. 1987 Oct 15; 262(29):13877-80.
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Liley HG, Hawgood S, Wellenstein GA, Benson B, White RT, Ballard PL. Surfactant protein of molecular weight 28,000-36,000 in cultured human fetal lung: cellular localization and effect of dexamethasone. Mol Endocrinol. 1987 Mar; 1(3):205-15.
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Wright JR, Wager RE, Hawgood S, Dobbs L, Clements JA. Surfactant apoprotein Mr = 26,000-36,000 enhances uptake of liposomes by type II cells. J Biol Chem. 1987 Feb 25; 262(6):2888-94.
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Efrati H, Hawgood S. Sialic acid of lung surfactant apoprotein, SP 28-36, is not required for the Ca2+-mediated interactions between surfactant lipids and SP 28-36. Biochim Biophys Acta. 1987 Feb 23; 917(3):425-7.
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Dobbs LG, Wright JR, Hawgood S, Gonzalez R, Venstrom K, Nellenbogen J. Pulmonary surfactant and its components inhibit secretion of phosphatidylcholine from cultured rat alveolar type II cells. Proc Natl Acad Sci U S A. 1987 Feb; 84(4):1010-4.
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Hawgood S, Benson BJ, Schilling J, Damm D, Clements JA, White RT. Nucleotide and amino acid sequences of pulmonary surfactant protein SP 18 and evidence for cooperation between SP 18 and SP 28-36 in surfactant lipid adsorption. Proc Natl Acad Sci U S A. 1987 Jan; 84(1):66-70.
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Ballard PL, Hawgood S, Liley H, Wellenstein G, Gonzales LW, Benson B, Cordell B, White RT. Regulation of pulmonary surfactant apoprotein SP 28-36 gene in fetal human lung. Proc Natl Acad Sci U S A. 1986 Dec; 83(24):9527-31.
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Dobbs LG, Gonzalez RF, Marinari LA, Mescher EJ, Hawgood S. The role of calcium in the secretion of surfactant by rat alveolar type II cells. Biochim Biophys Acta. 1986 Jun 27; 877(2):305-13.
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Hawgood S, Efrati H, Schilling J, Benson BJ. Chemical characterization of lung surfactant apoproteins: amino acid composition, N-terminal sequence and enzymic digestion. Biochem Soc Trans. 1985 Dec; 13(6):1092-6.
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Benson B, Hawgood S, Schilling J, Clements J, Damm D, Cordell B, White RT. Structure of canine pulmonary surfactant apoprotein: cDNA and complete amino acid sequence. Proc Natl Acad Sci U S A. 1985 Oct; 82(19):6379-83.
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White RT, Damm D, Miller J, Spratt K, Schilling J, Hawgood S, Benson B, Cordell B. Isolation and characterization of the human pulmonary surfactant apoprotein gene. Nature. 1985 Sep 26-Oct 2; 317(6035):361-3.
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Benson BJ, Hawgood S. Structural and functional aspects of protein: phospholipid interactions in surfactant. Eur J Respir Dis Suppl. 1985; 142:29-36.
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Hawgood S, Benson BJ, Hamilton RL. Effects of a surfactant-associated protein and calcium ions on the structure and surface activity of lung surfactant lipids. Biochemistry. 1985 Jan 1; 24(1):184-90.
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Phelps DS, Taeusch HW, Benson B, Hawgood S. An electrophoretic and immunochemical characterization of human surfactant-associated proteins. Biochim Biophys Acta. 1984 Dec 7; 791(2):226-38.
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Hawgood S, Spong J, Yu VY. Intraventricular hemorrhage. Incidence and outcome in a population of very-low-birth-weight infants. Am J Dis Child. 1984 Feb; 138(2):136-9.
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Benson BJ, Hawgood S, Williams MC. Role of apoprotein and calcium ions in surfactant function. Exp Lung Res. 1984; 6(3-4):223-36.
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Wilson FE, Yu VY, Hawgood S, Adamson TM, Wilkinson MH. Computerised nutritional data management in neonatal intensive care. Arch Dis Child. 1983 Sep; 58(9):732-6.
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Hawgood S, Adamson TM, Yu VY. Hospital referrals of home births in the intrapartum and postpartum periods. Med J Aust. 1981 Sep 19; 2(6):272-3.
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Ward LC, Miller M, Hawgood S. Simple and rapid high-performance liquid chromatographic method for the quantification of 3-methylhistidine. J Chromatogr. 1981 May 8; 223(2):417-20.
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Rendle-Short J, Tiernan JR, Hawgood S. Vegan mothers with vitamin B12 deficiency. Med J Aust. 1979 Nov 3; 2(9):483.
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Pearn J, Hawgood S. Bee-sting anaphylaxis in childhood. Med J Aust. 1979 Sep 8; 2(5):228-30.
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