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    Sophia Vinogradov, MD

    TitleProfessor in Residence
    SchoolUCSF School of Medicine
    DepartmentPsychiatry
    AddressVAMC
    Phone415-221-4810x3106

       Overview 
       Overview
      Sophia Vinogradov, M.D. is a Professor of Psychiatry in Residence; Interim Associate Chief of Staff for Mental Health, Associate Chief for Education and Research, Mental Health Service, at the San Francisco VA Medical Center; and Research Co-Director of the Prodrome Assessment, Research, and Treatment program at Langley Porter Psychiatric Institute, University of California, San Francisco. She received her M.D. from Wayne State University School of Medicine, obtained her psychiatry residency training at Stanford University School of Medicine, where she served as Chief Resident, and completed a Psychiatric Neurosciences Research Fellowship at the Palo Alto VA Medical Center and Stanford University.

      Clinical Expertise:
      psychopharmacologic treatment of serious mental disorders Psychopharmacologic treatment of serious mental disordersDiagnosis and treatment of psychotic disorders, Application of principles of cognitive and neuroscience to understanding of clinical disorders
      Educational Expertise:
      Brain, Mind, and Behavior—integrated neuroscience/neurology/psychiatry course for medical students; fundamentals of cognitive neuroscience as applied to human psychopathology and clinical psychopharmacology
      Research Areas:
      Dr. Vinogradov directs a translational clinical neuroscience laboratory that focuses on cognitive dysfunction in schizophrenia. In collaboration with basic neuroscientist, Michael Merzenich, Ph.D., she studies neuroscience-guided computerized cognitive training exercises for patients with schizophrenia that aim to drive enduring plastic changes in cortical processing. Dr. Vinogradov uses MEG and fMRI methods to probe the brain changes in both early sensory processing and higher-order cognitive operations in subjects who undergo this cognitive training. She is also examining changes in serum biomarkers (BDNF, D-serine) as a response to training. More recently, Dr. Vinogradov has begun to apply these methods to the study of adolescents who are prodromal for schizophrenia and young adults in early psychosis, with the goal of delaying or preventing the onset of a deteriorating psychiatric illness.


       Bibliographic 
       Publications
      Publications by year:
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      1. Vinogradov S, Fisher M, Nagarajan S. Cognitive training in schizophrenia: golden age or wild west? Biol Psychiatry. 2013 May 15; 73(10):935-7.
        View in: PubMed
      2. Fulford D, Niendam TA, Floyd EG, Carter CS, Mathalon DH, Vinogradov S, Stuart BK, Loewy RL. Symptom dimensions and functional impairment in early psychosis: More to the story than just negative symptoms. Schizophr Res. 2013 Jun; 147(1):125-31.
        View in: PubMed
      3. Herman AB, Houde JF, Vinogradov S, Nagarajan SS. Parsing the phonological loop: activation timing in the dorsal speech stream determines accuracy in speech reproduction. J Neurosci. 2013 Mar 27; 33(13):5439-53.
        View in: PubMed
      4. Fisher M, Loewy R, Hardy K, Schlosser D, Vinogradov S. Cognitive interventions targeting brain plasticity in the prodromal and early phases of schizophrenia. Annu Rev Clin Psychol. 2013 Mar 28; 9:435-63.
        View in: PubMed
      5. Subramaniam K, Vinogradov S. Cognitive training for psychiatric disorders. Neuropsychopharmacology. 2013 Jan; 38(1):242-3.
        View in: PubMed
      6. Leutwyler H, Hubbard EM, Jeste DV, Vinogradov S. "We're Not Just Sitting on the Periphery": A Staff Perspective of Physical Activity in Older Adults With Schizophrenia. Gerontologist. 2012 Aug 30.
        View in: PubMed
      7. Panizzutti R, Hamilton SP, Vinogradov S. Genetic correlate of cognitive training response in schizophrenia. Neuropharmacology. 2013 Jan; 64:264-7.
        View in: PubMed
      8. Hooker CI, Bruce L, Fisher M, Verosky SC, Miyakawa A, Vinogradov S. Neural activity during emotion recognition after combined cognitive plus social cognitive training in schizophrenia. Schizophr Res. 2012 Aug; 139(1-3):53-9.
        View in: PubMed
      9. Ellman LM, Vinogradov S, Kremen WS, Poole JH, Kern DM, Deicken RF, Brown AS. Low maternal hemoglobin during pregnancy and diminished neuromotor and neurocognitive performance in offspring with schizophrenia. Schizophr Res. 2012 Jun; 138(1):81-7.
        View in: PubMed
      10. Keefe RS, Vinogradov S, Medalia A, Buckley PF, Caroff SN, D'Souza DC, Harvey PD, Graham KA, Hamer RM, Marder SM, Miller del D, Olson SJ, Patel JK, Velligan D, Walker TM, Haim AJ, Stroup TS. Feasibility and pilot efficacy results from the multisite Cognitive Remediation in the Schizophrenia Trials Network (CRSTN) randomized controlled trial. J Clin Psychiatry. 2012 Jul; 73(7):1016-22.
        View in: PubMed
      11. Freedman D, Bao Y, Kremen WS, Vinogradov S, McKeague IW, Brown AS. Birth weight and neurocognition in schizophrenia spectrum disorders. Schizophr Bull. 2013 May; 39(3):592-600.
        View in: PubMed
      12. Subramaniam K, Luks TL, Fisher M, Simpson GV, Nagarajan S, Vinogradov S. Computerized cognitive training restores neural activity within the reality monitoring network in schizophrenia. Neuron. 2012 Feb 23; 73(4):842-53.
        View in: PubMed
      13. Perez VB, Ford JM, Roach BJ, Woods SW, McGlashan TH, Srihari VH, Loewy RL, Vinogradov S, Mathalon DH. Error monitoring dysfunction across the illness course of schizophrenia. J Abnorm Psychol. 2012 May; 121(2):372-87.
        View in: PubMed
      14. Vinogradov S, Fisher M, de Villers-Sidani E. Cognitive training for impaired neural systems in neuropsychiatric illness. Neuropsychopharmacology. 2012 Jan; 37(1):43-76.
        View in: PubMed
      15. Perez VB, Ford JM, Roach BJ, Loewy RL, Stuart BK, Vinogradov S, Mathalon DH. Auditory cortex responsiveness during talking and listening: early illness schizophrenia and patients at clinical high-risk for psychosis. Schizophr Bull. 2012 Nov; 38(6):1216-24.
        View in: PubMed
      16. Melhem N, Middleton F, McFadden K, Klei L, Faraone SV, Vinogradov S, Tiobech J, Yano V, Kuartei S, Roeder K, Byerley W, Devlin B, Myles-Worsley M. Copy number variants for schizophrenia and related psychotic disorders in Oceanic Palau: risk and transmission in extended pedigrees. Biol Psychiatry. 2011 Dec 15; 70(12):1115-21.
        View in: PubMed
      17. Hooker CI, Bruce L, Lincoln SH, Fisher M, Vinogradov S. Theory of mind skills are related to gray matter volume in the ventromedial prefrontal cortex in schizophrenia. Biol Psychiatry. 2011 Dec 15; 70(12):1169-78.
        View in: PubMed
      18. Hinkley LB, Vinogradov S, Guggisberg AG, Fisher M, Findlay AM, Nagarajan SS. Clinical symptoms and alpha band resting-state functional connectivity imaging in patients with schizophrenia: implications for novel approaches to treatment. Biol Psychiatry. 2011 Dec 15; 70(12):1134-42.
        View in: PubMed
      19. Brown AS, Vinogradov S, Kremen WS, Poole JH, Bao Y, Kern D, McKeague IW. Association of maternal genital and reproductive infections with verbal memory and motor deficits in adult schizophrenia. Psychiatry Res. 2011 Jul 30; 188(2):179-86.
        View in: PubMed
      20. Freedman D, Deicken R, Kegeles LS, Vinogradov S, Bao Y, Brown AS. Maternal-fetal blood incompatibility and neuromorphologic anomalies in schizophrenia: Preliminary findings. Prog Neuropsychopharmacol Biol Psychiatry. 2011 Aug 1; 35(6):1525-9.
        View in: PubMed
      21. Loewy RL, Pearson R, Vinogradov S, Bearden CE, Cannon TD. Psychosis risk screening with the Prodromal Questionnaire--brief version (PQ-B). Schizophr Res. 2011 Jun; 129(1):42-6.
        View in: PubMed
      22. Hooker CI, Tully LM, Verosky SC, Fisher M, Holland C, Vinogradov S. Can I trust you? Negative affective priming influences social judgments in schizophrenia. J Abnorm Psychol. 2011 Feb; 120(1):98-107.
        View in: PubMed
      23. Gard DE, Cooper S, Fisher M, Genevsky A, Mikels JA, Vinogradov S. Evidence for an emotion maintenance deficit in schizophrenia. Psychiatry Res. 2011 May 15; 187(1-2):24-9.
        View in: PubMed
      24. Hinkley LB, Owen JP, Fisher M, Findlay AM, Vinogradov S, Nagarajan SS. Cognitive Impairments in Schizophrenia as Assessed Through Activation and Connectivity Measures of Magnetoencephalography (MEG) Data. Front Hum Neurosci. 2010; 3:73.
        View in: PubMed
      25. Ellman LM, Deicken RF, Vinogradov S, Kremen WS, Poole JH, Kern DM, Tsai WY, Schaefer CA, Brown AS. Structural brain alterations in schizophrenia following fetal exposure to the inflammatory cytokine interleukin-8. Schizophr Res. 2010 Aug; 121(1-3):46-54.
        View in: PubMed
      26. Keefe RS, Vinogradov S, Medalia A, Silverstein SM, Bell MD, Dickinson D, Ventura J, Marder SR, Stroup TS. Report from the working group conference on multisite trial design for cognitive remediation in schizophrenia. Schizophr Bull. 2011 Sep; 37(5):1057-65.
        View in: PubMed
      27. Schlosser DA, Zinberg JL, Loewy RL, Casey-Cannon S, O'Brien MP, Bearden CE, Vinogradov S, Cannon TD. Predicting the longitudinal effects of the family environment on prodromal symptoms and functioning in patients at-risk for psychosis. Schizophr Res. 2010 May; 118(1-3):69-75.
        View in: PubMed
      28. Kremen WS, Vinogradov S, Poole JH, Schaefer CA, Deicken RF, Factor-Litvak P, Brown AS. Cognitive decline in schizophrenia from childhood to midlife: a 33-year longitudinal birth cohort study. Schizophr Res. 2010 May; 118(1-3):1-5.
        View in: PubMed
      29. Genevsky A, Garrett CT, Alexander PP, Vinogradov S. Cognitive training in schizophrenia: a neuroscience-based approach. Dialogues Clin Neurosci. 2010; 12(3):416-21.
        View in: PubMed
      30. Dale CL, Findlay AM, Adcock RA, Vertinski M, Fisher M, Genevsky A, Aldebot S, Subramaniam K, Luks TL, Simpson GV, Nagarajan SS, Vinogradov S. Timing is everything: neural response dynamics during syllable processing and its relation to higher-order cognition in schizophrenia and healthy comparison subjects. Int J Psychophysiol. 2010 Feb; 75(2):183-93.
        View in: PubMed
      31. Gard DE, Fisher M, Garrett C, Genevsky A, Vinogradov S. Motivation and its relationship to neurocognition, social cognition, and functional outcome in schizophrenia. Schizophr Res. 2009 Nov; 115(1):74-81.
        View in: PubMed
      32. Adcock RA, Dale C, Fisher M, Aldebot S, Genevsky A, Simpson GV, Nagarajan S, Vinogradov S. When top-down meets bottom-up: auditory training enhances verbal memory in schizophrenia. Schizophr Bull. 2009 Nov; 35(6):1132-41.
        View in: PubMed
      33. Vinogradov S, Fisher M, Warm H, Holland C, Kirshner MA, Pollock BG. The cognitive cost of anticholinergic burden: decreased response to cognitive training in schizophrenia. Am J Psychiatry. 2009 Sep; 166(9):1055-62.
        View in: PubMed
      34. Fisher M, Holland C, Merzenich MM, Vinogradov S. Using neuroplasticity-based auditory training to improve verbal memory in schizophrenia. Am J Psychiatry. 2009 Jul; 166(7):805-11.
        View in: PubMed
      35. Brown AS, Vinogradov S, Kremen WS, Poole JH, Deicken RF, Penner JD, McKeague IW, Kochetkova A, Kern D, Schaefer CA. Prenatal exposure to maternal infection and executive dysfunction in adult schizophrenia. Am J Psychiatry. 2009 Jun; 166(6):683-90.
        View in: PubMed
      36. Vinogradov S, Fisher M, Holland C, Shelly W, Wolkowitz O, Mellon SH. Is serum brain-derived neurotrophic factor a biomarker for cognitive enhancement in schizophrenia? Biol Psychiatry. 2009 Sep 15; 66(6):549-53.
        View in: PubMed
      37. Fisher M, Holland C, Subramaniam K, Vinogradov S. Neuroplasticity-based cognitive training in schizophrenia: an interim report on the effects 6 months later. Schizophr Bull. 2010 Jul; 36(4):869-79.
        View in: PubMed
      38. Brown AS, Deicken RF, Vinogradov S, Kremen WS, Poole JH, Penner JD, Kochetkova A, Kern D, Schaefer CA. Prenatal infection and cavum septum pellucidum in adult schizophrenia. Schizophr Res. 2009 Mar; 108(1-3):285-7.
        View in: PubMed
      39. Fisher M, McCoy K, Poole JH, Vinogradov S. Self and other in schizophrenia: a cognitive neuroscience perspective. Am J Psychiatry. 2008 Nov; 165(11):1465-72.
        View in: PubMed
      40. Browne A, Jakary A, Vinogradov S, Fu Y, Deicken RF. Automatic relevance determination for identifying thalamic regions implicated in schizophrenia. IEEE Trans Neural Netw. 2008 Jun; 19(6):1101-7.
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      41. Vinogradov S, Luks TL, Schulman BJ, Simpson GV. Deficit in a neural correlate of reality monitoring in schizophrenia patients. Cereb Cortex. 2008 Nov; 18(11):2532-9.
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      42. Sanders AR, Duan J, Levinson DF, Shi J, He D, Hou C, Burrell GJ, Rice JP, Nertney DA, Olincy A, Rozic P, Vinogradov S, Buccola NG, Mowry BJ, Freedman R, Amin F, Black DW, Silverman JM, Byerley WF, Crowe RR, Cloninger CR, Martinez M, Gejman PV. No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics. Am J Psychiatry. 2008 Apr; 165(4):497-506.
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      43. Minzenberg MJ, Poole JH, Vinogradov S. A neurocognitive model of borderline personality disorder: effects of childhood sexual abuse and relationship to adult social attachment disturbance. Dev Psychopathol. 2008; 20(1):341-68.
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      44. Kumra S, Oberstar JV, Sikich L, Findling RL, McClellan JM, Vinogradov S, Charles Schulz S. Efficacy and tolerability of second-generation antipsychotics in children and adolescents with schizophrenia. Schizophr Bull. 2008 Jan; 34(1):60-71.
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      45. Minzenberg MJ, Poole JH, Vinogradov S. Social-emotion recognition in borderline personality disorder. Compr Psychiatry. 2006 Nov-Dec; 47(6):468-74.
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      46. Minzenberg MJ, Poole JH, Vinogradov S. Adult social attachment disturbance is related to childhood maltreatment and current symptoms in borderline personality disorder. J Nerv Ment Dis. 2006 May; 194(5):341-8.
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      47. Vinogradov S, Luks TL, Simpson GV, Schulman BJ, Glenn S, Wong AE. Brain activation patterns during memory of cognitive agency. Neuroimage. 2006 Jun; 31(2):896-905.
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      48. Minzenberg MJ, Fisher-Irving M, Poole JH, Vinogradov S. Reduced Self-Referential Source Memory Performance is Associated with Interpersonal Dysfunction in Borderline Personality Disorder. J Pers Disord. 2006 Feb; 20(1):42-54.
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      49. Jakary A, Vinogradov S, Feiwell R, Deicken RF. N-acetylaspartate reductions in the mediodorsal and anterior thalamus in men with schizophrenia verified by tissue volume corrected proton MRSI. Schizophr Res. 2005 Jul 15; 76(2-3):173-85.
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      50. Minzenberg MJ, Poole JH, Benton C, Vinogradov S. Association of anticholinergic load with impairment of complex attention and memory in schizophrenia. Am J Psychiatry. 2004 Jan; 161(1):116-24.
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      51. Minzenberg MJ, Poole JH, Vinogradov S, Shenaut GK, Ober BA. Slowed lexical access is uniquely associated with positive and disorganised symptoms in schizophrenia. Cogn Neuropsychiatry. 2003 May; 8(2):107-27.
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      52. Pegues MP, Rogers LJ, Amend D, Vinogradov S, Deicken RF. Anterior hippocampal volume reduction in male patients with schizophrenia. Schizophr Res. 2003 Apr 1; 60(2-3):105-15.
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      53. Vinogradov S, Kirkland J, Poole JH, Drexler M, Ober BA, Shenaut GK. Both processing speed and semantic memory organization predict verbal fluency in schizophrenia. Schizophr Res. 2003 Feb 1; 59(2-3):269-75.
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      54. Escamilla MA, Batki S, Reus VI, Spesny M, Molina J, Service S, Vinogradov S, Neylan T, Mathews C, Meza L, Gallegos A, Montero AP, Cruz ML, Neuhaus J, Roche E, Smith L, Leon P, Freimer NB. Comorbidity of bipolar disorder and substance abuse in Costa Rica: pedigree- and population-based studies. J Affect Disord. 2002 Sep; 71(1-3):71-83.
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      55. Minzenberg MJ, Ober BA, Vinogradov S. Semantic priming in schizophrenia: a review and synthesis. J Int Neuropsychol Soc. 2002 Jul; 8(5):699-720.
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      56. Marco EJ, Wolkowitz OM, Vinogradov S, Poole JH, Lichtmacher J, Reus VI. Double-blind antiglucocorticoid treatment in schizophrenia and schizoaffective disorder: a pilot study. World J Biol Psychiatry. 2002 Jul; 3(3):156-61.
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      57. Escamilla MA, McInnes LA, Service SK, Spesny M, Reus VI, Molina J, Gallegos A, Fournier E, Batki S, Neylan T, Matthews C, Vinogradov S, Roche E, Tyler DJ, Shimayoshi N, Mendez R, Ramirez R, Ramirez M, Araya C, Araya X, Leon PE, Sandkuijl LA, Freimer NB. Genome screening for linkage disequilibrium in a Costa Rican sample of patients with bipolar-I disorder: a follow-up study on chromosome 18. Am J Med Genet. 2001 Mar 8; 105(2):207-13.
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      58. Poole JH, Tobias FC, Vinogradov S. The functional relevance of affect recognition errors in schizophrenia. J Int Neuropsychol Soc. 2000 Sep; 6(6):649-58.
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      59. Escamilla MA, McInnes LA, Spesny M, Reus VI, Service SK, Shimayoshi N, Tyler DJ, Silva S, Molina J, Gallegos A, Meza L, Cruz ML, Batki S, Vinogradov S, Neylan T, Nguyen JB, Fournier E, Araya C, Barondes SH, Leon P, Sandkuijl LA, Freimer NB. Assessing the feasibility of linkage disequilibrium methods for mapping complex traits: an initial screen for bipolar disorder loci on chromosome 18. Am J Hum Genet. 1999 Jun; 64(6):1670-8.
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      60. Poole JH, Ober BA, Shenaut GK, Vinogradov S. Independent frontal-system deficits in schizophrenia: cognitive, clinical, and adaptive implications. Psychiatry Res. 1999 Feb 22; 85(2):161-76.
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      61. Vinogradov S, Poole JH, Willis-Shore J, Ober BA, Shenaut GK. Slower and more variable reaction times in schizophrenia: what do they signify? Schizophr Res. 1998 Aug 17; 32(3):183-90.
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      62. Vinogradov S, Willis-Shore J, Poole JH, Marten E, Ober BA, Shenaut GK. Clinical and neurocognitive aspects of source monitoring errors in schizophrenia. Am J Psychiatry. 1997 Nov; 154(11):1530-7.
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      63. Deicken RF, Zhou L, Corwin F, Vinogradov S, Weiner MW. Decreased left frontal lobe N-acetylaspartate in schizophrenia. Am J Psychiatry. 1997 May; 154(5):688-90.
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      64. McInnes LA, Escamilla MA, Service SK, Reus VI, Leon P, Silva S, Rojas E, Spesny M, Baharloo S, Blankenship K, Peterson A, Tyler D, Shimayoshi N, Tobey C, Batki S, Vinogradov S, Meza L, Gallegos A, Fournier E, Smith LB, Barondes SH, Sandkuijl LA, Freimer NB. A complete genome screen for genes predisposing to severe bipolar disorder in two Costa Rican pedigrees. Proc Natl Acad Sci U S A. 1996 Nov 12; 93(23):13060-5.
        View in: PubMed
      65. Freimer NB, Reus VI, Escamilla M, Spesny M, Smith L, Service S, Gallegos A, Meza L, Batki S, Vinogradov S, Leon P, Sandkuijl LA. An approach to investigating linkage for bipolar disorder using large Costa Rican pedigrees. Am J Med Genet. 1996 May 31; 67(3):254-63.
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      66. Vinogradov S, Solomon S, Ober BA, Biggins CA, Shenaut GK, Fein G. Do semantic priming effects correlate with sensory gating in schizophrenia? Biol Psychiatry. 1996 May 1; 39(9):821-4.
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      67. Freimer NB, Reus VI, Escamilla MA, McInnes LA, Spesny M, Leon P, Service SK, Smith LB, Silva S, Rojas E, Gallegos A, Meza L, Fournier E, Baharloo S, Blankenship K, Tyler DJ, Batki S, Vinogradov S, Weissenbach J, Barondes SH, Sandkuijl LA. Genetic mapping using haplotype, association and linkage methods suggests a locus for severe bipolar disorder (BPI) at 18q22-q23. Nat Genet. 1996 Apr; 12(4):436-41.
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      68. Deicken RF, Calabrese G, Merrin EL, Vinogradov S, Fein G, Weiner MW. Asymmetry of temporal lobe phosphorous metabolism in schizophrenia: a 31phosphorous magnetic resonance spectroscopic imaging study. Biol Psychiatry. 1995 Sep 1; 38(5):279-86.
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      69. Vinogradov S, Ober BA, Shenaut GK. Semantic priming of word pronunciation and lexical decision in schizophrenia. Schizophr Res. 1992 Dec; 8(2):171-81.
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      70. Vinogradov S, King RJ, Huberman BA. An associationist model of the paranoid process: application of phase transitions in spreading activation networks. Psychiatry. 1992 Feb; 55(1):79-94.
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      71. Vinogradov S, Gottesman II, Moises HW, Nicol S. Negative association between schizophrenia and rheumatoid arthritis. Schizophr Bull. 1991; 17(4):669-78.
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      72. Vinogradov S, Csernansky JG. Postpartum psychosis with abnormal movements: dopamine supersensitivity unmasked by withdrawal of endogenous estrogens? J Clin Psychiatry. 1990 Sep; 51(9):365-6.
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