Synthia Mellon, PhD

Title(s)Professor, Ob/Gyn, Reproductive Sciences
SchoolSchool of Medicine
Address513 Parnassus Ave, HSW
San Francisco CA 94143
Phone415-502-4844
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    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Cell Aging in Major Depression
    NIH R01MH083784Jul 1, 2008 - Feb 28, 2021
    Role: Co-Principal Investigator
    Origins and Biological Consequences of Human Infertility
    NIH U54HD055764May 3, 2007 - Mar 31, 2017
    Role: Co-Investigator
    Center for Research, Innovation and Training in Reproduction and Infertility
    NIH P50HD055764Apr 1, 2007 - Mar 31, 2023
    Role: Co-Investigator
    Neurosteroids in health and disease
    NIH U01NS049462Jun 15, 2005 - May 31, 2012
    Role: Principal Investigator
    Regulation of Reproduction
    NIH R01HD027970Aug 1, 1991 - Jun 30, 2006
    Role: Principal Investigator
    HORMONAL REGULATION OF STEROIDOGENESIS
    NIH R29HD022013Aug 1, 1986 - Jul 31, 1991
    Role: Principal Investigator
    HORMONAL REGULATION OF STEROIDOGENESIS
    NIH R23HD022013Aug 1, 1986 - Jul 31, 1989
    Role: Principal Investigator
    Integrated Training in Reproductive Sciences
    NIH T32HD007263Jul 1, 1983 - Apr 30, 2024
    Role: Principal Investigator
    General Clinical Research Center
    NIH M01RR000079Dec 1, 1974 - Mar 31, 2009
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Utilization of machine learning for identifying symptom severity military-related PTSD subtypes and their biological correlates. Transl Psychiatry. 2021 04 20; 11(1):227. Siegel CE, Laska EM, Lin Z, Xu M, Abu-Amara D, Jeffers MK, Qian M, Milton N, Flory JD, Hammamieh R, Daigle BJ, Gautam A, Dean KR, Reus VI, Wolkowitz OM, Mellon SH, Ressler KJ, Yehuda R, Wang K, Hood L, Doyle FJ, Jett M, Marmar CR. PMID: 33879773.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. "GrimAge," an epigenetic predictor of mortality, is accelerated in major depressive disorder. Transl Psychiatry. 2021 04 06; 11(1):193. Protsenko E, Yang R, Nier B, Reus V, Hammamieh R, Rampersaud R, Wu GWY, Hough CM, Epel E, Prather AA, Jett M, Gautam A, Mellon SH, Wolkowitz OM. PMID: 33820909.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Epigenetic biotypes of post-traumatic stress disorder in war-zone exposed veteran and active duty males. Mol Psychiatry. 2020 Dec 18. Yang R, Gautam A, Getnet D, Daigle BJ, Miller S, Misganaw B, Dean KR, Kumar R, Muhie S, Wang K, Lee I, Abu-Amara D, Flory JD, PTSD Systems Biology Consortium , Hood L, Wolkowitz OM, Mellon SH, Doyle FJ, Yehuda R, Marmar CR, Ressler KJ, Hammamieh R, Jett M. PMID: 33339956.
      View in: PubMed   Mentions: 1     Fields:    
    4. Correction: A DNA methylation clock associated with age-related illnesses and mortality is accelerated in men with combat PTSD. Mol Psychiatry. 2020 Jul 10. Yang R, Wu GWY, Verhoeven JE, Gautam A, Reus VI, Kang JI, Flory JD, Abu-Amara D, PTSD Systems Biology Consortium , Hood L, Doyle FJ, Yehuda R, Marmar CR, Jett M, Hammamieh R, Mellon SH, Wolkowitz OM. PMID: 32651479.
      View in: PubMed   Mentions:    Fields:    
    5. Pre-deployment risk factors for PTSD in active-duty personnel deployed to Afghanistan: a machine-learning approach for analyzing multivariate predictors. Mol Psychiatry. 2020 Jun 02. Schultebraucks K, Qian M, Abu-Amara D, Dean K, Laska E, Siegel C, Gautam A, Guffanti G, Hammamieh R, Misganaw B, Mellon SH, Wolkowitz OM, Blessing EM, Etkin A, Ressler KJ, Doyle FJ, Jett M, Marmar CR. PMID: 32488126.
      View in: PubMed   Mentions: 6     Fields:    
    6. Pre-treatment allostatic load and metabolic dysregulation predict SSRI response in major depressive disorder: a preliminary report. Psychol Med. 2020 May 22; 1-9. Hough CM, Bersani FS, Mellon SH, Morford AE, Lindqvist D, Reus VI, Epel ES, Wolkowitz OM. PMID: 32438932.
      View in: PubMed   Mentions:    Fields:    
    7. A DNA methylation clock associated with age-related illnesses and mortality is accelerated in men with combat PTSD. Mol Psychiatry. 2020 May 07. Yang R, Wu GWY, Verhoeven JE, Gautam A, Reus VI, Kang JI, Flory JD, Abu-Amara D, PTSD Systems Biology Consortium , Hood L, Doyle FJ, Yehuda R, Marmar CR, Jett M, Hammamieh R, Mellon SH, Wolkowitz OM. PMID: 32382136.
      View in: PubMed   Mentions: 3     Fields:    
    8. Role of enhanced glucocorticoid receptor sensitivity in inflammation in PTSD: insights from computational model for circadian-neuroendocrine-immune interactions. Am J Physiol Endocrinol Metab. 2020 07 01; 319(1):E48-E66. Somvanshi PR, Mellon SH, Yehuda R, Flory JD, Makotkine I, Bierer L, Marmar C, Jett M, Doyle FJ. PMID: 32315214.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    9. Effect of Combat Exposure and Posttraumatic Stress Disorder on Telomere Length and Amygdala Volume. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 07; 5(7):678-687. Kang JI, Mueller SG, Wu GWY, Lin J, Ng P, Yehuda R, Flory JD, Abu-Amara D, Reus VI, Gautam A, PTSD Systems Biology Consortium , Hammamieh R, Doyle FJ, Jett M, Marmar CR, Mellon SH, Wolkowitz OM. PMID: 32439402.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    10. Vitamin D and inflammation in major depressive disorder. J Affect Disord. 2020 04 15; 267:33-41. Grudet C, Wolkowitz OM, Mellon SH, Malm J, Reus VI, Brundin L, Nier BM, Dhabhar FS, Hough CM, Westrin Å, Lindqvist D. PMID: 32063570.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    11. Novel Pharmacological Targets for Combat PTSD-Metabolism, Inflammation, The Gut Microbiome, and Mitochondrial Dysfunction. Mil Med. 2020 01 07; 185(Suppl 1):311-318. Bersani FS, Mellon SH, Lindqvist D, Kang JI, Rampersaud R, Somvanshi PR, Doyle FJ, Hammamieh R, Jett M, Yehuda R, Marmar CR, Wolkowitz OM. PMID: 32074311.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    12. Multi-omic biomarker identification and validation for diagnosing warzone-related post-traumatic stress disorder. Mol Psychiatry. 2020 12; 25(12):3337-3349. Dean KR, Hammamieh R, Mellon SH, Abu-Amara D, Flory JD, Guffanti G, Wang K, Daigle BJ, Gautam A, Lee I, Yang R, Almli LM, Bersani FS, Chakraborty N, Donohue D, Kerley K, Kim TK, Laska E, Young Lee M, Lindqvist D, Lori A, Lu L, Misganaw B, Muhie S, Newman J, Price ND, Qin S, Reus VI, Siegel C, Somvanshi PR, Thakur GS, Zhou Y, PTSD Systems Biology Consortium , Hood L, Ressler KJ, Wolkowitz OM, Yehuda R, Jett M, Doyle FJ, Marmar C. PMID: 31501510.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    13. Accelerated aging in serious mental disorders. Curr Opin Psychiatry. 2019 09; 32(5):381-387. Bersani FS, Mellon SH, Reus VI, Wolkowitz OM. PMID: 31145144.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    14. Cortisol, moderated by age, is associated with antidepressant treatment outcome and memory improvement in Major Depressive Disorder: A retrospective analysis. Psychoneuroendocrinology. 2019 11; 109:104386. Jain FA, Connolly CG, Reus VI, Meyerhoff DJ, Yang TT, Mellon SH, Mackin S, Hough CM, Morford A, Wolkowitz OM. PMID: 31382170.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    15. Mechanistic inferences on metabolic dysfunction in posttraumatic stress disorder from an integrated model and multiomic analysis: role of glucocorticoid receptor sensitivity. Am J Physiol Endocrinol Metab. 2019 11 01; 317(5):E879-E898. Somvanshi PR, Mellon SH, Flory JD, Abu-Amara D, PTSD Systems Biology Consortium; , Wolkowitz OM, Yehuda R, Jett M, Hood L, Marmar C, Doyle FJ. PMID: 31322414.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    16. Accelerating research on biological aging and mental health: Current challenges and future directions. Psychoneuroendocrinology. 2019 08; 106:293-311. Han LKM, Verhoeven JE, Tyrka AR, Penninx BWJH, Wolkowitz OM, Månsson KNT, Lindqvist D, Boks MP, Révész D, Mellon SH, Picard M. PMID: 31154264.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    17. Metabolomic analysis of male combat veterans with post traumatic stress disorder. PLoS One. 2019; 14(3):e0213839. Mellon SH, Bersani FS, Lindqvist D, Hammamieh R, Donohue D, Dean K, Jett M, Yehuda R, Flory J, Reus VI, Bierer LM, Makotkine I, Abu Amara D, Henn Haase C, Coy M, Doyle FJ, Marmar C, Wolkowitz OM. PMID: 30883584.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    18. Low serum brain-derived neurotrophic factor is associated with suicidal ideation in major depressive disorder. Psychiatry Res. 2019 03; 273:108-113. Khan MS, Wu GWY, Reus VI, Hough CM, Lindqvist D, Westrin Å, Nier BM, Wolkowitz OM, Mellon SH. PMID: 30640051.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    19. Epigenetic Age in Male Combat-Exposed War Veterans: Associations with Posttraumatic Stress Disorder Status. Mol Neuropsychiatry. 2018 Oct; 4(2):90-99. Verhoeven JE, Yang R, Wolkowitz OM, Bersani FS, Lindqvist D, Mellon SH, Yehuda R, Flory JD, Lin J, Abu-Amara D, Makotkine I, Marmar C, Jett M, Hammamieh R. PMID: 30397597.
      View in: PubMed   Mentions:
    20. Posttraumatic stress disorder, symptoms, and white matter abnormalities among combat-exposed veterans. Brain Imaging Behav. 2018 Aug; 12(4):989-999. Aschbacher K, Mellon SH, Wolkowitz OM, Henn-Haase C, Yehuda R, Flory JD, Bierer LM, Abu-Amara D, Marmar CR, Mueller SG. PMID: 28823023.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    21. Metabolism, Metabolomics, and Inflammation in Posttraumatic Stress Disorder. Biol Psychiatry. 2018 05 15; 83(10):866-875. Mellon SH, Gautam A, Hammamieh R, Jett M, Wolkowitz OM. PMID: 29628193.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    22. Circulating cell-free mitochondrial DNA, but not leukocyte mitochondrial DNA copy number, is elevated in major depressive disorder. Neuropsychopharmacology. 2018 06; 43(7):1557-1564. Lindqvist D, Wolkowitz OM, Picard M, Ohlsson L, Bersani FS, Fernström J, Westrin Å, Hough CM, Lin J, Reus VI, Epel ES, Mellon SH. PMID: 29453441.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCellsCTClinical Trials
    23. Increased circulating blood cell counts in combat-related PTSD: Associations with inflammation and PTSD severity. Psychiatry Res. 2017 12; 258:330-336. Lindqvist D, Mellon SH, Dhabhar FS, Yehuda R, Grenon SM, Flory JD, Bierer LM, Abu-Amara D, Coy M, Makotkine I, Reus VI, Aschbacher K, Bersani FS, Marmar CR, Wolkowitz OM. PMID: 28942957.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    24. Telomere length is inversely correlated with urinary stress hormone levels in healthy controls but not in un-medicated depressed individuals-preliminary findings. J Psychosom Res. 2017 08; 99:177-180. Fair B, Mellon SH, Epel ES, Lin J, Révész D, Verhoeven JE, Penninx BW, Reus VI, Rosser R, Hough CM, Mahan L, Burke HM, Blackburn EH, Wolkowitz OM. PMID: 28712425.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    25. Severity of anxiety- but not depression- is associated with oxidative stress in Major Depressive Disorder. J Affect Disord. 2017 09; 219:193-200. Steenkamp LR, Hough CM, Reus VI, Jain FA, Epel ES, James SJ, Morford AE, Mellon SH, Wolkowitz OM, Lindqvist D. PMID: 28564628.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    26. Biological predictors of insulin resistance associated with posttraumatic stress disorder in young military veterans. Psychoneuroendocrinology. 2017 Aug; 82:91-97. Blessing EM, Reus V, Mellon SH, Wolkowitz OM, Flory JD, Bierer L, Lindqvist D, Dhabhar F, Li M, Qian M, Abu-Amara D, Galatzer-Levy I, Yehuda R, Marmar CR. PMID: 28521179.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    27. Higher serum DHEA concentrations before and after SSRI treatment are associated with remission of major depression. Psychoneuroendocrinology. 2017 03; 77:122-130. Hough CM, Lindqvist D, Epel ES, Denis MS, Reus VI, Bersani FS, Rosser R, Mahan L, Burke HM, Wolkowitz OM, Mellon SH. PMID: 28038403.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    28. Oxidative stress, inflammation and treatment response in major depression. Psychoneuroendocrinology. 2017 02; 76:197-205. Lindqvist D, Dhabhar FS, James SJ, Hough CM, Jain FA, Bersani FS, Reus VI, Verhoeven JE, Epel ES, Mahan L, Rosser R, Wolkowitz OM, Mellon SH. PMID: 27960139.
      View in: PubMed   Mentions: 56     Fields:    Translation:Humans
    29. Increased pro-inflammatory milieu in combat related PTSD - A new cohort replication study. Brain Behav Immun. 2017 Jan; 59:260-264. Lindqvist D, Dhabhar FS, Mellon SH, Yehuda R, Grenon SM, Flory JD, Bierer LM, Abu-Amara D, Coy M, Makotkine I, Reus VI, Bersani FS, Marmar CR, Wolkowitz OM. PMID: 27638184.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    30. Cortisol/DHEA ratio and hippocampal volume: A pilot study in major depression and healthy controls. Psychoneuroendocrinology. 2016 10; 72:139-46. Jin RO, Mason S, Mellon SH, Epel ES, Reus VI, Mahan L, Rosser RL, Hough CM, Burke HM, Mueller SG, Wolkowitz OM. PMID: 27428086.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    31. Leukocyte telomere length predicts SSRI response in major depressive disorder: A preliminary report. Mol Neuropsychiatry. 2016 Jul; 2(2):88-96. Hough CM, Bersani FS, Mellon SH, Epel ES, Reus VI, Lindqvist D, Lin J, Mahan L, Rosser R, Burke H, Coetzee J, Nelson JC, Blackburn EH, Wolkowitz OM. PMID: 27429957.
      View in: PubMed   Mentions:
    32. A population of atypical CD56(-)CD16(+) natural killer cells is expanded in PTSD and is associated with symptom severity. Brain Behav Immun. 2016 Aug; 56:264-70. Bersani FS, Wolkowitz OM, Milush JM, Sinclair E, Eppling L, Aschbacher K, Lindqvist D, Yehuda R, Flory J, Bierer LM, Matokine I, Abu-Amara D, Reus VI, Coy M, Hough CM, Marmar CR, Mellon SH. PMID: 27025668.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    33. Neuroscience-informed Auditory Training in Schizophrenia: A Final Report of the Effects on Cognition and Serum Brain-Derived Neurotrophic Factor. Schizophr Res Cogn. 2016 Mar 01; 3:1-7. Fisher M, Mellon SH, Wolkowitz O, Vinogradov S. PMID: 26705516.
      View in: PubMed   Mentions:
    34. Association of dimensional psychological health measures with telomere length in male war veterans. J Affect Disord. 2016 Jan 15; 190:537-542. Bersani FS, Lindqvist D, Mellon SH, Epel ES, Yehuda R, Flory J, Henn-Hasse C, Bierer LM, Makotkine I, Abu-Amara D, Coy M, Reus VI, Lin J, Blackburn EH, Marmar C, Wolkowitz OM. PMID: 26571103.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    35. Global arginine bioavailability, a marker of nitric oxide synthetic capacity, is decreased in PTSD and correlated with symptom severity and markers of inflammation. Brain Behav Immun. 2016 Feb; 52:153-160. Bersani FS, Wolkowitz OM, Lindqvist D, Yehuda R, Flory J, Bierer LM, Makotine I, Abu-Amara D, Coy M, Reus VI, Epel ES, Marmar C, Mellon SH. PMID: 26515034.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    36. Evidence for disrupted gray matter structural connectivity in posttraumatic stress disorder. Psychiatry Res. 2015 Nov 30; 234(2):194-201. Mueller SG, Ng P, Neylan T, Mackin S, Wolkowitz O, Mellon S, Yan X, Flory J, Yehuda R, Marmar CR, Weiner MW. PMID: 26419357.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    37. Telomerase activation as a possible mechanism of action for psychopharmacological interventions. Drug Discov Today. 2015 Nov; 20(11):1305-9. Bersani FS, Lindqvist D, Mellon SH, Penninx BW, Verhoeven JE, Révész D, Reus VI, Wolkowitz OM. PMID: 26166813.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    38. Mitochondrial DNA copy number is reduced in male combat veterans with PTSD. Prog Neuropsychopharmacol Biol Psychiatry. 2016 Jan 04; 64:10-7. Bersani FS, Morley C, Lindqvist D, Epel ES, Picard M, Yehuda R, Flory J, Bierer LM, Makotkine I, Abu-Amara D, Coy M, Reus VI, Lin J, Blackburn EH, Marmar C, Wolkowitz OM, Mellon SH. PMID: 26120081.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    39. Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging. Neurosci Biobehav Rev. 2015 Aug; 55:333-64. Lindqvist D, Epel ES, Mellon SH, Penninx BW, Révész D, Verhoeven JE, Reus VI, Lin J, Mahan L, Hough CM, Rosser R, Bersani FS, Blackburn EH, Wolkowitz OM. PMID: 25999120.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansCells
    40. PBMC telomerase activity, but not leukocyte telomere length, correlates with hippocampal volume in major depression. Psychiatry Res. 2015 Apr 30; 232(1):58-64. Wolkowitz OM, Mellon SH, Lindqvist D, Epel ES, Blackburn EH, Lin J, Reus VI, Burke H, Rosser R, Mahan L, Mackin S, Yang T, Weiner M, Mueller S. PMID: 25773002.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    41. Peripheral antioxidant markers are associated with total hippocampal and CA3/dentate gyrus volume in MDD and healthy controls-preliminary findings. Psychiatry Res. 2014 Dec 30; 224(3):168-74. Lindqvist D, Mueller S, Mellon SH, Su Y, Epel ES, Reus VI, Rosser R, Mahan L, Mackin RS, Yang TT, Wolkowitz OM. PMID: 25266915.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    42. Adverse childhood experiences and leukocyte telomere maintenance in depressed and healthy adults. J Affect Disord. 2014 Dec; 169:86-90. Chen SH, Epel ES, Mellon SH, Lin J, Reus VI, Rosser R, Kupferman E, Burke H, Mahan L, Blackburn EH, Wolkowitz OM. PMID: 25173430.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    43. Proinflammatory milieu in combat-related PTSD is independent of depression and early life stress. Brain Behav Immun. 2014 Nov; 42:81-8. Lindqvist D, Wolkowitz OM, Mellon S, Yehuda R, Flory JD, Henn-Haase C, Bierer LM, Abu-Amara D, Coy M, Neylan TC, Makotkine I, Reus VI, Yan X, Taylor NM, Marmar CR, Dhabhar FS. PMID: 24929195.
      View in: PubMed   Mentions: 56     Fields:    Translation:Humans
    44. A culture system to study oligodendrocyte myelination processes using engineered nanofibers. Nat Methods. 2012 Sep; 9(9):917-22. Lee S, Leach MK, Redmond SA, Chong SY, Mellon SH, Tuck SJ, Feng ZQ, Corey JM, Chan JR. PMID: 22796663.
      View in: PubMed   Mentions: 139     Fields:    Translation:AnimalsCells
    45. Expression of P450c17 in the human fetal nervous system. Endocrinology. 2012 May; 153(5):2494-505. Schonemann MD, Muench MO, Tee MK, Miller WL, Mellon SH. PMID: 22434081.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    46. Oligogenesis and oligodendrocyte progenitor maturation vary in different brain regions and partially correlate with local angiogenesis after ischemic stroke. Transl Stroke Res. 2011 Sep; 2(3):366-75. Jiang L, Shen F, Degos V, Schonemann M, Pleasure SJ, Mellon SH, Young WL, Su H. PMID: 22022343.
      View in: PubMed   Mentions: 6     Fields:    
    47. Serum BDNF levels before treatment predict SSRI response in depression. Prog Neuropsychopharmacol Biol Psychiatry. 2011 Aug 15; 35(7):1623-30. Wolkowitz OM, Wolf J, Shelly W, Rosser R, Burke HM, Lerner GK, Reus VI, Nelson JC, Epel ES, Mellon SH. PMID: 21749907.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCTClinical Trials
    48. Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress--preliminary findings. PLoS One. 2011 Mar 23; 6(3):e17837. Wolkowitz OM, Mellon SH, Epel ES, Lin J, Dhabhar FS, Su Y, Reus VI, Rosser R, Burke HM, Kupferman E, Compagnone M, Nelson JC, Blackburn EH. PMID: 21448457.
      View in: PubMed   Mentions: 152     Fields:    Translation:HumansCells
    49. Of sound mind and body: depression, disease, and accelerated aging. Dialogues Clin Neurosci. 2011; 13(1):25-39. Wolkowitz OM, Reus VI, Mellon SH. PMID: 21485744.
      View in: PubMed   Mentions: 70     Fields:    Translation:Humans
    50. Estrogen receptor beta-selective agonists stimulate calcium oscillations in human and mouse embryonic stem cell-derived neurons. PLoS One. 2010 Jul 27; 5(7):e11791. Zhang L, Blackman BE, Schonemann MD, Zogovic-Kapsalis T, Pan X, Tagliaferri M, Harris HA, Cohen I, Pera RA, Mellon SH, Weiner RI, Leitman DC. PMID: 20668547.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    51. Serum brain-derived neurotrophic factor predicts responses to escitalopram in chronic posttraumatic stress disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2010 Oct 01; 34(7):1279-84. Berger W, Mehra A, Lenoci M, Metzler TJ, Otte C, Tarasovsky G, Mellon SH, Wolkowitz OM, Marmar CR, Neylan TC. PMID: 20643177.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCTClinical Trials
    52. Depression gets old fast: do stress and depression accelerate cell aging? Depress Anxiety. 2010 Apr; 27(4):327-38. Wolkowitz OM, Epel ES, Reus VI, Mellon SH. PMID: 20376837.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansCells
    53. Analyses and comparisons of telomerase activity and telomere length in human T and B cells: insights for epidemiology of telomere maintenance. J Immunol Methods. 2010 Jan 31; 352(1-2):71-80. Lin J, Epel E, Cheon J, Kroenke C, Sinclair E, Bigos M, Wolkowitz O, Mellon S, Blackburn E. PMID: 19837074.
      View in: PubMed   Mentions: 184     Fields:    Translation:HumansCells
    54. Low serum IL-10 concentrations and loss of regulatory association between IL-6 and IL-10 in adults with major depression. J Psychiatr Res. 2009 Jul; 43(11):962-9. Dhabhar FS, Burke HM, Epel ES, Mellon SH, Rosser R, Reus VI, Wolkowitz OM. PMID: 19552919.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    55. Is serum brain-derived neurotrophic factor a biomarker for cognitive enhancement in schizophrenia? Biol Psychiatry. 2009 Sep 15; 66(6):549-53. Vinogradov S, Fisher M, Holland C, Shelly W, Wolkowitz O, Mellon SH. PMID: 19368899.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansCTClinical Trials
    56. Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS). Front Neuroendocrinol. 2009 Jan; 30(1):65-91. Maninger N, Wolkowitz OM, Reus VI, Epel ES, Mellon SH. PMID: 19063914.
      View in: PubMed   Mentions: 160     Fields:    Translation:HumansAnimals
    57. Regulation of P450c17 expression in the early embryo depends on GATA factors. Endocrinology. 2009 Feb; 150(2):946-56. Shi Y, Schonemann MD, Mellon SH. PMID: 18832096.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    58. Oxidative stress in NPC1 deficient cells: protective effect of allopregnanolone. J Cell Mol Med. 2009 Sep; 13(9B):3786-96. Zampieri S, Mellon SH, Butters TD, Nevyjel M, Covey DF, Bembi B, Dardis A. PMID: 18774957.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    59. When blue turns to grey: do stress and depression accelerate cell aging? World J Biol Psychiatry. 2008; 9(1):2-5. Wolkowitz OM, Epel ES, Mellon S. PMID: 18273736.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    60. Neurosteroid regulation of central nervous system development. Pharmacol Ther. 2007 Oct; 116(1):107-24. Mellon SH. PMID: 17651807.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    61. Endogenous and synthetic neurosteroids in treatment of Niemann-Pick Type C disease. Brain Res Rev. 2008 Mar; 57(2):410-20. Mellon SH, Gong W, Schonemann MD. PMID: 17629950.
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    62. Translin coactivates steroidogenic factor-1-stimulated transcription. Mol Endocrinol. 2007 Jan; 21(1):89-105. Mellon SH, Bair SR, Depoix C, Vigne JL, Hecht NB, Brake PB. PMID: 17053042.
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    63. Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C disease. Proc Natl Acad Sci U S A. 2006 Sep 12; 103(37):13807-12. Langmade SJ, Gale SE, Frolov A, Mohri I, Suzuki K, Mellon SH, Walkley SU, Covey DF, Schaffer JE, Ory DS. PMID: 16940355.
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    64. DNA sequence-dependent regulation of SF-1-mediated transcription. DNA Cell Biol. 2005 Mar; 24(3):148-60. Brake PB, Bair SR, Mellon SH. PMID: 15767781.
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    65. Niemann pick type C disease as a model for defects in neurosteroidogenesis. Endocr Res. 2004 Nov; 30(4):727-35. Mellon S, Gong W, Griffin LD. PMID: 15666818.
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    66. Niemann-Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnanolone. Nat Med. 2004 Jul; 10(7):704-11. Griffin LD, Gong W, Verot L, Mellon SH. PMID: 15208706.
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    67. Deletion of the mouse P450c17 gene causes early embryonic lethality. Mol Cell Biol. 2004 Jun; 24(12):5383-90. Bair SR, Mellon SH. PMID: 15169901.
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    68. The Endocrine Society Ethics Advisory Committee: ethical aspects of conflicts of interests, October 2003. Endocrinology. 2004 Jun; 145(6):3032-41. Komesaroff PA, Bach MA, Danoff A, Grumbach MM, Kaplan S, Lakoski JM, Leitman D, Mellon S, Underwood LE, Leupen S, Endocrine Society Ethics Advisory Committee . PMID: 15140839.
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    69. Molecular mechanism of suppression of testicular steroidogenesis by proinflammatory cytokine tumor necrosis factor alpha. Mol Cell Biol. 2004 Apr; 24(7):2593-604. Hong CY, Park JH, Ahn RS, Im SY, Choi HS, Soh J, Mellon SH, Lee K. PMID: 15024051.
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    70. Transcriptional regulation of P450scc gene expression in the embryonic rodent nervous system. Endocrinology. 2004 Feb; 145(2):901-12. Hammer F, Compagnone NA, Vigne JL, Bair SR, Mellon SH. PMID: 14576192.
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    71. Protein phosphatase 2A and phosphoprotein SET regulate androgen production by P450c17. J Biol Chem. 2003 Jan 31; 278(5):2837-44. Pandey AV, Mellon SH, Miller WL. PMID: 12444089.
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    72. Synthesis, regulation, and function of neurosteroids. Endocr Res. 2002 Nov; 28(4):463. Mellon SH, Griffin LD. PMID: 12530649.
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    73. Dietary phosphorus transcriptionally regulates 25-hydroxyvitamin D-1alpha-hydroxylase gene expression in the proximal renal tubule. Endocrinology. 2002 Feb; 143(2):587-95. Zhang MY, Wang X, Wang JT, Compagnone NA, Mellon SH, Olson JL, Tenenhouse HS, Miller WL, Portale AA. PMID: 11796514.
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    74. Neurosteroids: biochemistry and clinical significance. Trends Endocrinol Metab. 2002 Jan-Feb; 13(1):35-43. Mellon SH, Griffin LD. PMID: 11750861.
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