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Synthia Mellon, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentOb/Gyn, Reproductive Sciences
Address513 Parnassus Ave
San Francisco CA 94143
Phone415-476-5329
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    Collapse Research 
    Collapse Research Activities and Funding
    Cell Aging in Major Depression
    NIH/NIMH R01MH083784Jul 1, 2008 - Feb 29, 2020
    Role: Co-Principal Investigator
    Origins and Biological Consequences of Human Infertility
    NIH/NICHD U54HD055764May 3, 2007 - Mar 31, 2017
    Role: Co-Investigator
    Center for Research, Innovation and Training in Reproduction and Infertility
    NIH/NICHD P50HD055764Apr 1, 2007 - Mar 31, 2023
    Role: Co-Investigator
    Neurosteroids in health and disease
    NIH/NINDS U01NS049462Jun 15, 2005 - May 31, 2012
    Role: Principal Investigator
    Regulation of Reproduction
    NIH/NICHD R01HD027970Aug 1, 1991 - Jun 30, 2006
    Role: Principal Investigator
    HORMONAL REGULATION OF STEROIDOGENESIS
    NIH/NICHD R29HD022013Aug 1, 1986 - Jul 31, 1991
    Role: Principal Investigator
    HORMONAL REGULATION OF STEROIDOGENESIS
    NIH/NICHD R23HD022013Aug 1, 1986 - Jul 31, 1989
    Role: Principal Investigator
    Integrated Training in Reproductive Sciences
    NIH/NICHD T32HD007263Jul 1, 1983 - Apr 30, 2019
    Role: Principal Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000079Dec 1, 1974 - Mar 31, 2009
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Global Health
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Mellon SH, Gautam A, Hammamieh R, Jett M, Wolkowitz OM. Metabolism, Metabolomics, and Inflammation in Posttraumatic Stress Disorder. Biol Psychiatry. 2018 May 15; 83(10):866-875. PMID: 29628193.
      View in: PubMed
    2. Lindqvist D, Wolkowitz OM, Picard M, Ohlsson L, Bersani FS, Fernström J, Westrin Å, Hough CM, Lin J, Reus VI, Epel ES, Mellon SH. Circulating cell-free mitochondrial DNA, but not leukocyte mitochondrial DNA copy number, is elevated in major depressive disorder. Neuropsychopharmacology. 2018 Jan 30. PMID: 29453441.
      View in: PubMed
    3. Lindqvist D, Mellon SH, Dhabhar FS, Yehuda R, Grenon SM, Flory JD, Bierer LM, Abu-Amara D, Coy M, Makotkine I, Reus VI, Aschbacher K, Bersani FS, Marmar CR, Wolkowitz OM. Increased circulating blood cell counts in combat-related PTSD: Associations with inflammation and PTSD severity. Psychiatry Res. 2017 Dec; 258:330-336. PMID: 28942957.
      View in: PubMed
    4. Aschbacher K, Mellon SH, Wolkowitz OM, Henn-Haase C, Yehuda R, Flory JD, Bierer LM, Abu-Amara D, Marmar CR, Mueller SG. Posttraumatic stress disorder, symptoms, and white matter abnormalities among combat-exposed veterans. Brain Imaging Behav. 2017 Aug 19. PMID: 28823023.
      View in: PubMed
    5. Fair B, Mellon SH, Epel ES, Lin J, Révész D, Verhoeven JE, Penninx BW, Reus VI, Rosser R, Hough CM, Mahan L, Burke HM, Blackburn EH, Wolkowitz OM. Telomere length is inversely correlated with urinary stress hormone levels in healthy controls but not in un-medicated depressed individuals-preliminary findings. J Psychosom Res. 2017 Aug; 99:177-180. PMID: 28712425.
      View in: PubMed
    6. Steenkamp LR, Hough CM, Reus VI, Jain FA, Epel ES, James SJ, Morford AE, Mellon SH, Wolkowitz OM, Lindqvist D. Severity of anxiety- but not depression- is associated with oxidative stress in Major Depressive Disorder. J Affect Disord. 2017 09; 219:193-200. PMID: 28564628.
      View in: PubMed
    7. Blessing EM, Reus V, Mellon SH, Wolkowitz OM, Flory JD, Bierer L, Lindqvist D, Dhabhar F, Li M, Qian M, Abu-Amara D, Galatzer-Levy I, Yehuda R, Marmar CR. Biological predictors of insulin resistance associated with posttraumatic stress disorder in young military veterans. Psychoneuroendocrinology. 2017 Aug; 82:91-97. PMID: 28521179.
      View in: PubMed
    8. Hough CM, Lindqvist D, Epel ES, Denis MS, Reus VI, Bersani FS, Rosser R, Mahan L, Burke HM, Wolkowitz OM, Mellon SH. Higher serum DHEA concentrations before and after SSRI treatment are associated with remission of major depression. Psychoneuroendocrinology. 2017 Mar; 77:122-130. PMID: 28038403.
      View in: PubMed
    9. Lindqvist D, Dhabhar FS, James SJ, Hough CM, Jain FA, Bersani FS, Reus VI, Verhoeven JE, Epel ES, Mahan L, Rosser R, Wolkowitz OM, Mellon SH. Oxidative stress, inflammation and treatment response in major depression. Psychoneuroendocrinology. 2017 Feb; 76:197-205. PMID: 27960139.
      View in: PubMed
    10. Lindqvist D, Dhabhar FS, Mellon SH, Yehuda R, Grenon SM, Flory JD, Bierer LM, Abu-Amara D, Coy M, Makotkine I, Reus VI, Bersani FS, Marmar CR, Wolkowitz OM. Increased pro-inflammatory milieu in combat related PTSD - A new cohort replication study. Brain Behav Immun. 2017 Jan; 59:260-264. PMID: 27638184.
      View in: PubMed
    11. Jin RO, Mason S, Mellon SH, Epel ES, Reus VI, Mahan L, Rosser RL, Hough CM, Burke HM, Mueller SG, Wolkowitz OM. Cortisol/DHEA ratio and hippocampal volume: A pilot study in major depression and healthy controls. Psychoneuroendocrinology. 2016 Oct; 72:139-46. PMID: 27428086.
      View in: PubMed
    12. Hough CM, Bersani FS, Mellon SH, Epel ES, Reus VI, Lindqvist D, Lin J, Mahan L, Rosser R, Burke H, Coetzee J, Nelson JC, Blackburn EH, Wolkowitz OM. Leukocyte telomere length predicts SSRI response in major depressive disorder: A preliminary report. Mol Neuropsychiatry. 2016 Jul; 2(2):88-96. PMID: 27429957.
      View in: PubMed
    13. Bersani FS, Wolkowitz OM, Milush JM, Sinclair E, Eppling L, Aschbacher K, Lindqvist D, Yehuda R, Flory J, Bierer LM, Matokine I, Abu-Amara D, Reus VI, Coy M, Hough CM, Marmar CR, Mellon SH. A population of atypical CD56(-)CD16(+) natural killer cells is expanded in PTSD and is associated with symptom severity. Brain Behav Immun. 2016 Aug; 56:264-70. PMID: 27025668.
      View in: PubMed
    14. Fisher M, Mellon SH, Wolkowitz O, Vinogradov S. Neuroscience-informed Auditory Training in Schizophrenia: A Final Report of the Effects on Cognition and Serum Brain-Derived Neurotrophic Factor. Schizophr Res Cogn. 2016 Mar 01; 3:1-7. PMID: 26705516.
      View in: PubMed
    15. Bersani FS, Lindqvist D, Mellon SH, Epel ES, Yehuda R, Flory J, Henn-Hasse C, Bierer LM, Makotkine I, Abu-Amara D, Coy M, Reus VI, Lin J, Blackburn EH, Marmar C, Wolkowitz OM. Association of dimensional psychological health measures with telomere length in male war veterans. J Affect Disord. 2016 Jan 15; 190:537-542. PMID: 26571103.
      View in: PubMed
    16. Bersani FS, Wolkowitz OM, Lindqvist D, Yehuda R, Flory J, Bierer LM, Makotine I, Abu-Amara D, Coy M, Reus VI, Epel ES, Marmar C, Mellon SH. Global arginine bioavailability, a marker of nitric oxide synthetic capacity, is decreased in PTSD and correlated with symptom severity and markers of inflammation. Brain Behav Immun. 2016 Feb; 52:153-160. PMID: 26515034.
      View in: PubMed
    17. Mueller SG, Ng P, Neylan T, Mackin S, Wolkowitz O, Mellon S, Yan X, Flory J, Yehuda R, Marmar CR, Weiner MW. Evidence for disrupted gray matter structural connectivity in posttraumatic stress disorder. Psychiatry Res. 2015 Nov 30; 234(2):194-201. PMID: 26419357.
      View in: PubMed
    18. Bersani FS, Lindqvist D, Mellon SH, Penninx BW, Verhoeven JE, Révész D, Reus VI, Wolkowitz OM. Telomerase activation as a possible mechanism of action for psychopharmacological interventions. Drug Discov Today. 2015 Nov; 20(11):1305-9. PMID: 26166813.
      View in: PubMed
    19. Bersani FS, Morley C, Lindqvist D, Epel ES, Picard M, Yehuda R, Flory J, Bierer LM, Makotkine I, Abu-Amara D, Coy M, Reus VI, Lin J, Blackburn EH, Marmar C, Wolkowitz OM, Mellon SH. Mitochondrial DNA copy number is reduced in male combat veterans with PTSD. Prog Neuropsychopharmacol Biol Psychiatry. 2016 Jan 04; 64:10-7. PMID: 26120081.
      View in: PubMed
    20. Lindqvist D, Epel ES, Mellon SH, Penninx BW, Révész D, Verhoeven JE, Reus VI, Lin J, Mahan L, Hough CM, Rosser R, Bersani FS, Blackburn EH, Wolkowitz OM. Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging. Neurosci Biobehav Rev. 2015 Aug; 55:333-64. PMID: 25999120; PMCID: PMC4501875.
    21. Wolkowitz OM, Mellon SH, Lindqvist D, Epel ES, Blackburn EH, Lin J, Reus VI, Burke H, Rosser R, Mahan L, Mackin S, Yang T, Weiner M, Mueller S. PBMC telomerase activity, but not leukocyte telomere length, correlates with hippocampal volume in major depression. Psychiatry Res. 2015 Apr 30; 232(1):58-64. PMID: 25773002; PMCID: PMC4404215.
    22. Lindqvist D, Mueller S, Mellon SH, Su Y, Epel ES, Reus VI, Rosser R, Mahan L, Mackin RS, Yang TT, Wolkowitz OM. Peripheral antioxidant markers are associated with total hippocampal and CA3/dentate gyrus volume in MDD and healthy controls-preliminary findings. Psychiatry Res. 2014 Dec 30; 224(3):168-74. PMID: 25266915; PMCID: PMC4254356.
    23. Chen SH, Epel ES, Mellon SH, Lin J, Reus VI, Rosser R, Kupferman E, Burke H, Mahan L, Blackburn EH, Wolkowitz OM. Adverse childhood experiences and leukocyte telomere maintenance in depressed and healthy adults. J Affect Disord. 2014 Dec; 169:86-90. PMID: 25173430; PMCID: PMC4172492.
    24. Lindqvist D, Wolkowitz OM, Mellon S, Yehuda R, Flory JD, Henn-Haase C, Bierer LM, Abu-Amara D, Coy M, Neylan TC, Makotkine I, Reus VI, Yan X, Taylor NM, Marmar CR, Dhabhar FS. Proinflammatory milieu in combat-related PTSD is independent of depression and early life stress. Brain Behav Immun. 2014 Nov; 42:81-8. PMID: 24929195.
      View in: PubMed
    25. Lee S, Leach MK, Redmond SA, Chong SY, Mellon SH, Tuck SJ, Feng ZQ, Corey JM, Chan JR. A culture system to study oligodendrocyte myelination processes using engineered nanofibers. Nat Methods. 2012 Sep; 9(9):917-22. PMID: 22796663; PMCID: PMC3433633.
    26. Schonemann MD, Muench MO, Tee MK, Miller WL, Mellon SH. Expression of P450c17 in the human fetal nervous system. Endocrinology. 2012 May; 153(5):2494-505. PMID: 22434081; PMCID: PMC3339640.
    27. Jiang L, Shen F, Degos V, Schonemann M, Pleasure SJ, Mellon SH, Young WL, Su H. Oligogenesis and oligodendrocyte progenitor maturation vary in different brain regions and partially correlate with local angiogenesis after ischemic stroke. Transl Stroke Res. 2011 Sep; 2(3):366-75. PMID: 22022343; PMCID: PMC3196661.
    28. Wolkowitz OM, Wolf J, Shelly W, Rosser R, Burke HM, Lerner GK, Reus VI, Nelson JC, Epel ES, Mellon SH. Serum BDNF levels before treatment predict SSRI response in depression. Prog Neuropsychopharmacol Biol Psychiatry. 2011 Aug 15; 35(7):1623-30. PMID: 21749907; PMCID: PMC3159044.
    29. Wolkowitz OM, Mellon SH, Epel ES, Lin J, Dhabhar FS, Su Y, Reus VI, Rosser R, Burke HM, Kupferman E, Compagnone M, Nelson JC, Blackburn EH. Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress--preliminary findings. PLoS One. 2011 Mar 23; 6(3):e17837. PMID: 21448457; PMCID: PMC3063175.
    30. Wolkowitz OM, Reus VI, Mellon SH. Of sound mind and body: depression, disease, and accelerated aging. Dialogues Clin Neurosci. 2011; 13(1):25-39. PMID: 21485744; PMCID: PMC3181963.
    31. Zhang L, Blackman BE, Schonemann MD, Zogovic-Kapsalis T, Pan X, Tagliaferri M, Harris HA, Cohen I, Pera RA, Mellon SH, Weiner RI, Leitman DC. Estrogen receptor beta-selective agonists stimulate calcium oscillations in human and mouse embryonic stem cell-derived neurons. PLoS One. 2010 Jul 27; 5(7):e11791. PMID: 20668547.
      View in: PubMed
    32. Berger W, Mehra A, Lenoci M, Metzler TJ, Otte C, Tarasovsky G, Mellon SH, Wolkowitz OM, Marmar CR, Neylan TC. Serum brain-derived neurotrophic factor predicts responses to escitalopram in chronic posttraumatic stress disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2010 Oct 01; 34(7):1279-84. PMID: 20643177; PMCID: PMC2939182.
    33. Wolkowitz OM, Epel ES, Reus VI, Mellon SH. Depression gets old fast: do stress and depression accelerate cell aging? Depress Anxiety. 2010 Apr; 27(4):327-38. PMID: 20376837.
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    34. Lin J, Epel E, Cheon J, Kroenke C, Sinclair E, Bigos M, Wolkowitz O, Mellon S, Blackburn E. Analyses and comparisons of telomerase activity and telomere length in human T and B cells: insights for epidemiology of telomere maintenance. J Immunol Methods. 2010 Jan 31; 352(1-2):71-80. PMID: 19837074; PMCID: PMC3280689.
    35. Dhabhar FS, Burke HM, Epel ES, Mellon SH, Rosser R, Reus VI, Wolkowitz OM. Low serum IL-10 concentrations and loss of regulatory association between IL-6 and IL-10 in adults with major depression. J Psychiatr Res. 2009 Jul; 43(11):962-9. PMID: 19552919.
      View in: PubMed
    36. Vinogradov S, Fisher M, Holland C, Shelly W, Wolkowitz O, Mellon SH. Is serum brain-derived neurotrophic factor a biomarker for cognitive enhancement in schizophrenia? Biol Psychiatry. 2009 Sep 15; 66(6):549-53. PMID: 19368899; PMCID: PMC4691262.
    37. Maninger N, Wolkowitz OM, Reus VI, Epel ES, Mellon SH. Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS). Front Neuroendocrinol. 2009 Jan; 30(1):65-91. PMID: 19063914; PMCID: PMC2725024.
    38. Shi Y, Schonemann MD, Mellon SH. Regulation of P450c17 expression in the early embryo depends on GATA factors. Endocrinology. 2009 Feb; 150(2):946-56. PMID: 18832096; PMCID: PMC2646537.
    39. Zampieri S, Mellon SH, Butters TD, Nevyjel M, Covey DF, Bembi B, Dardis A. Oxidative stress in NPC1 deficient cells: protective effect of allopregnanolone. J Cell Mol Med. 2009 Sep; 13(9B):3786-96. PMID: 18774957; PMCID: PMC2832077.
    40. Wolkowitz OM, Epel ES, Mellon S. When blue turns to grey: do stress and depression accelerate cell aging? World J Biol Psychiatry. 2008; 9(1):2-5. PMID: 18273736.
      View in: PubMed
    41. Mellon SH. Neurosteroid regulation of central nervous system development. Pharmacol Ther. 2007 Oct; 116(1):107-24. PMID: 17651807; PMCID: PMC2386997.
    42. Mellon SH, Gong W, Schonemann MD. Endogenous and synthetic neurosteroids in treatment of Niemann-Pick Type C disease. Brain Res Rev. 2008 Mar; 57(2):410-20. PMID: 17629950; PMCID: PMC2323675.
    43. Mellon SH, Bair SR, Depoix C, Vigne JL, Hecht NB, Brake PB. Translin coactivates steroidogenic factor-1-stimulated transcription. Mol Endocrinol. 2007 Jan; 21(1):89-105. PMID: 17053042.
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    44. Langmade SJ, Gale SE, Frolov A, Mohri I, Suzuki K, Mellon SH, Walkley SU, Covey DF, Schaffer JE, Ory DS. Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C disease. Proc Natl Acad Sci U S A. 2006 Sep 12; 103(37):13807-12. PMID: 16940355; PMCID: PMC1564205.
    45. Brake PB, Bair SR, Mellon SH. DNA sequence-dependent regulation of SF-1-mediated transcription. DNA Cell Biol. 2005 Mar; 24(3):148-60. PMID: 15767781.
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    46. Mellon S, Gong W, Griffin LD. Niemann pick type C disease as a model for defects in neurosteroidogenesis. Endocr Res. 2004 Nov; 30(4):727-35. PMID: 15666818.
      View in: PubMed
    47. Griffin LD, Gong W, Verot L, Mellon SH. Niemann-Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnanolone. Nat Med. 2004 Jul; 10(7):704-11. PMID: 15208706.
      View in: PubMed
    48. Bair SR, Mellon SH. Deletion of the mouse P450c17 gene causes early embryonic lethality. Mol Cell Biol. 2004 Jun; 24(12):5383-90. PMID: 15169901; PMCID: PMC419874.
    49. Komesaroff PA, Bach MA, Danoff A, Grumbach MM, Kaplan S, Lakoski JM, Leitman D, Mellon S, Underwood LE, Leupen S. The Endocrine Society Ethics Advisory Committee: ethical aspects of conflicts of interests, October 2003. Endocrinology. 2004 Jun; 145(6):3032-41. PMID: 15140839.
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    50. Hong CY, Park JH, Ahn RS, Im SY, Choi HS, Soh J, Mellon SH, Lee K. Molecular mechanism of suppression of testicular steroidogenesis by proinflammatory cytokine tumor necrosis factor alpha. Mol Cell Biol. 2004 Apr; 24(7):2593-604. PMID: 15024051; PMCID: PMC371106.
    51. Hammer F, Compagnone NA, Vigne JL, Bair SR, Mellon SH. Transcriptional regulation of P450scc gene expression in the embryonic rodent nervous system. Endocrinology. 2004 Feb; 145(2):901-12. PMID: 14576192.
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    52. Pandey AV, Mellon SH, Miller WL. Protein phosphatase 2A and phosphoprotein SET regulate androgen production by P450c17. J Biol Chem. 2003 Jan 31; 278(5):2837-44. PMID: 12444089.
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    53. Mellon SH, Griffin LD. Synthesis, regulation, and function of neurosteroids. Endocr Res. 2002 Nov; 28(4):463. PMID: 12530649.
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    54. Zhang MY, Wang X, Wang JT, Compagnone NA, Mellon SH, Olson JL, Tenenhouse HS, Miller WL, Portale AA. Dietary phosphorus transcriptionally regulates 25-hydroxyvitamin D-1alpha-hydroxylase gene expression in the proximal renal tubule. Endocrinology. 2002 Feb; 143(2):587-95. PMID: 11796514.
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    55. Mellon SH, Griffin LD. Neurosteroids: biochemistry and clinical significance. Trends Endocrinol Metab. 2002 Jan-Feb; 13(1):35-43. PMID: 11750861.
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