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    Sunita Ho, MS, PhD

    TitleAssociate Professor
    SchoolUCSF School of Dentistry
    DepartmentPreventive & Restor Dent Sci
    Address707 Parnassus Ave, Dentistry
    San Francisco CA 94143
    Phone415-514-2818

       Overview 
       Overview
      Mechanical loads manifest into strains within tissues and interfaces of an organ. Strains within tissues are transduced by the cells to produce the needed extracellular matrix proteins to meet functional demands. This is the general philosophy of research in my laboratory which is within the Division of Biomaterials and Bioengineering. Our lab has a strong focus on mechanics, materials, and investigating adaptation of tissues/interfaces through spatiotemporal mapping of “mechano-responsiveness”. This is done by correlating mechanical strain induced biochemical signals at soft-hard tissue interfaces using several model systems including the bone-ligament-tooth fibrous joint.

      Due to the interdisciplinary nature of research, my laboratory is extended to the Molecular Foundry of Lawrence Berkeley National Laboratory, and Stanford Synchrotron Radiation Lightsource (SSRL) at Stanford Linear Accelerator Center (SLAC) with the help of NIH and DOE funded/peer-reviewed proposals. Mapping of biochemical expressions, physical properties of load bearing tissues, and biomechanics of organs are performed at UCSF, and as a guest scientist at the national laboratories/facilities.


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       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Zhang Y, Kim JY, Horst O, Nakano Y, Zhu L, Radlanski RJ, Ho S, Besten PK. Fluorosed Mouse Ameloblasts Have Increased SATB1 Retention and Gaq Activity. PLoS One. 2014; 9(8):e103994.
        View in: PubMed
      2. Jang AT, Lin JD, Choi RM, Choi EM, Seto ML, Ryder MI, Gansky SA, Curtis DA, Ho SP. Adaptive properties of human cementum and cementum dentin junction with age. J Mech Behav Biomed Mater. 2014 Jul 24; 39C:184-196.
        View in: PubMed
      3. Lin JD, Lee J, Ozcoban H, Schneider GA, Ho SP. Biomechanical adaptation of the bone-periodontal ligament (PDL)-tooth fibrous joint as a consequence of disease. J Biomech. 2014 Jun 27; 47(9):2102-14.
        View in: PubMed
      4. Kathryn Grandfield, Ralf Peter Herber, Sabra Djomehri, Caleb Tam, Ji-Hyun Lee, Evan Brown, Wood R. Woolwine III, Don Curtis, Mark Ryder, Jim Schuck, Samuel Webb, William Landis, Sunita Ho. Strain-guided mineralization in the bone-PDL-cementum complex of a rat periodontium (under review). 2013.
      5. Y-C Chien, A.K. Burwell, K. Saeki, A. Fernandez-Martinez, M.K. Pugach, G. Nonomura, S. Habelitz, S.P. Ho, M. Rapozo-Hilo, J.D. Featherstone, S.J. Marshall and G.W. Marshall . Acetic and lactic acids create different artificial dentin lesions: kinetics, ultrastructure and mechanical properties (under review). 2013.
      6. Ho SP, Kurylo MP, Grandfield K, Hurng J, Herber RP, Ryder MI, Altoe V, Aloni S, Feng JQ, Webb S, Marshall GW, Curtis D, Andrews JC, Pianetta P. The plastic nature of the human bone-periodontal ligament-tooth fibrous joint. Bone. 2013 Dec; 57(2):455-67.
        View in: PubMed
      7. Lee JH, Lin JD, Fong JI, Ryder MI, Ho SP. The adaptive nature of the bone-periodontal ligament-cementum complex in a ligature-induced periodontitis rat model. Biomed Res Int. 2013; 2013:876316.
        View in: PubMed
      8. Biehs B, Hu JK, Strauli NB, Sangiorgi E, Jung H, Heber RP, Ho S, Goodwin AF, Dasen JS, Capecchi MR, Klein OD. BMI1 represses Ink4a/Arf and Hox genes to regulate stem cells in the rodent incisor. Nat Cell Biol. 2013 Jul; 15(7):846-52.
        View in: PubMed
      9. Lin, J.D. and Aloni, S. and Altoe, V. and Webb, S.M. and Ryder, M.I. and Ho, S.P. Elastic discontinuity due to ectopic calcification in a human fibrous joint. Acta Biomaterilia. 2013; 1(9):4787-4795.
      10. Lin, J.D. and Özcoban, H. and Greene, J.P. and Jang, A.T. and Djomehri, S.I. and Fahey, K.P. and Hunter, L.L. and Schneider, G.A. and Ho, S.P. . Biomechanics of a bone-periodontal ligament-tooth fibrous joint. Journal of Biomechanics. 2013; (46):443-449.
      11. Lin JD, Özcoban H, Greene JP, Jang AT, Djomehri SI, Fahey KP, Hunter LL, Schneider GA, Ho SP. Biomechanics of a bone-periodontal ligament-tooth fibrous joint. J Biomech. 2013 Feb 1; 46(3):443-9.
        View in: PubMed
      12. Tang SY, Herber RP, Ho SP, Alliston T. Matrix metalloproteinase-13 is required for osteocytic perilacunar remodeling and maintains bone fracture resistance. J Bone Miner Res. 2012 Sep; 27(9):1936-50.
        View in: PubMed
      13. Burwell AK, Thula-Mata T, Gower LB, Habelitz S, Habeliz S, Kurylo M, Ho SP, Chien YC, Cheng J, Cheng NF, Gansky SA, Marshall SJ, Marshall GW. Functional remineralization of dentin lesions using polymer-induced liquid-precursor process. PLoS One. 2012; 7(6):e38852.
        View in: PubMed
      14. Chiu, R. and Li, W. and Herber, R.P. and Marshall, S.J. and Young, M. and Ho, S.P. Effects of biglycan on physico-chemical properties of ligament-mineralized tissue attachment sites. Archives of Oral Biology. 2012; 57(2):177-187.
      15. Herber, R, Fong, J, Lucas, S & Ho, S. Imaging an Adapted Dentoalveolar Complex. Anatomy Research International. 2012; 24(11):3482-13.
      16. Leong, N.L. and Hurng, J.M. and Djomehri, S.I. and Gansky, S.A. and Ryder, M.I. and Ho, S.P., . PLoS One. Age-related adaptation of bone-PDL-tooth complex: Rattus-Norvegicus as a model system. 2012; 7(4).
      17. Niver EL, Leong N, Greene J, Curtis D, Ryder MI, Ho SP. Reduced functional loads alter the physical characteristics of the bone-periodontal ligament-cementum complex. J Periodontal Res. 2011 Dec; 46(6):730-41.
        View in: PubMed
      18. Hurng JM, Kurylo MP, Marshall GW, Webb SM, Ryder MI, Ho SP. Discontinuities in the human bone-PDL-cementum complex. Biomaterials. 2011 Oct; 32(29):7106-17.
        View in: PubMed
      19. Zhang Y, Kim SO, Opsahl-Vital S, Ho SP, Souron JB, Kim C, Giles K, Den Besten PK. Multiple effects of the cellular prion protein on tooth development. Int J Dev Biol. 2011; 55(10-12):953-60.
        View in: PubMed
      20. Ho SP, Kurylo MP, Fong TK, Lee SS, Wagner HD, Ryder MI, Marshall GW. The biomechanical characteristics of the bone-periodontal ligament-cementum complex. Biomaterials. 2010 Sep; 31(25):6635-46.
        View in: PubMed
      21. Vaderhobli RM, White JM, Le C, Ho S, Jordan R. In vitro study of the soft tissue effects of microsecond-pulsed CO(2) laser parameters during soft tissue incision and sulcular debridement. Lasers Surg Med. 2010 Mar; 42(3):257-63.
        View in: PubMed
      22. Ho SP, Senkyrikova P, Marshall GW, Yun W, Wang Y, Karan K, Li C, Marshall SJ. Structure, chemical composition and mechanical properties of coronal cementum in human deciduous molars. Dent Mater. 2009 Oct; 25(10):1195-204.
        View in: PubMed
      23. Varanasi, V.G. and Saiz, E. and Loomer, P.M. and Ancheta, B. and Uritani, N. and Ho, S.P. and Tomsia, A.P. and Marshall, S.J. and Marshall, G.W. Enhanced osteocalcin expression by osteoblast-like cells (MC3T3-E1) exposed to bioactive coating glass (SiO2-CaO-P2O5-MgO-K2O-Na2O system) ions. Acta Biomaterilia. 2009; 5(9):3536-3547.
      24. Ho SP, Yu B, Yun W, Marshall GW, Ryder MI, Marshall SJ. Structure, chemical composition and mechanical properties of human and rat cementum and its interface with root dentin. Acta Biomater. 2009 Feb; 5(2):707-18.
        View in: PubMed
      25. Ho SP, Marshall SJ, Ryder MI, Marshall GW. The tooth attachment mechanism defined by structure, chemical composition and mechanical properties of collagen fibers in the periodontium. Biomaterials. 2007 Dec; 28(35):5238-45.
        View in: PubMed
      26. A.C. Clark, S. P. Ho, M. LaBerge. Tribology International. Conductive Composite of UHMWPE and CB as a Dynamic Contact Analysis Sensor. 2006; (39):1327-1335.
      27. Caldwell Rebecca, LaBerge Martine, and Ho Sunita. Advances in Polymeric Biomaterials. Surface Modification of Articulating Surfaces and Tribological Evaluation. 2006; 303-335.
      28. Ho SP, Sulyanto RM, Marshall SJ, Marshall GW. The cementum-dentin junction also contains glycosaminoglycans and collagen fibrils. J Struct Biol. 2005 Jul; 151(1):69-78.
        View in: PubMed
      29. Ho SP, Balooch M, Marshall SJ, Marshall GW. Local properties of a functionally graded interphase between cementum and dentin. J Biomed Mater Res A. 2004 Sep 1; 70(3):480-9.
        View in: PubMed
      30. Ho SP, Goodis H, Balooch M, Nonomura G, Marshall SJ, Marshall G. The effect of sample preparation technique on determination of structure and nanomechanical properties of human cementum hard tissue. Biomaterials. 2004 Aug; 25(19):4847-57.
        View in: PubMed
      31. Ho SP, Balooch M, Goodis HE, Marshall GW, Marshall SJ. Ultrastructure and nanomechanical properties of cementum dentin junction. J Biomed Mater Res A. 2004 Feb 1; 68(2):343-51.
        View in: PubMed
      32. Ho SP, Joseph PF, Drews MJ, Boland T, LaBerge M. Experimental and numerical modeling of variable friction between nanoregions in coventional and crosslinked UHMWPE. J Biomech Eng. 2004 Feb; 126(1):111-9.
        View in: PubMed
      33. Ho SP, Nakabayashi N, Iwasaki Y, Boland T, LaBerge M. Frictional properties of poly(MPC-co-BMA) phospholipid polymer for catheter applications. Biomaterials. 2003 Dec; 24(28):5121-9.
        View in: PubMed
      34. Ho SP, Riester L, Drews M, Boland T, LaBerge M. Nanoindentation properties of compression-moulded ultra-high molecular weight polyethylene. Proc Inst Mech Eng H. 2003; 217(5):357-66.
        View in: PubMed
      35. Caldwell RA, Woodell JE, Ho SP, Shalaby SW, Boland T, Langan EM, LaBerge M. In vitro evaluation of phosphonylated low-density polyethylene for vascular applications. J Biomed Mater Res. 2002 Dec 15; 62(4):514-24.
        View in: PubMed
      36. S. P. Ho, R. W. Carpick, T. Boland, M. LaBerge. Wear. Nanotribology of CoCr-UHMWPE TJR Prosthesis Using Atomic Force Microscopy. 2002; 11-12(253):1145-1155.
      37. Ho SP, Riester L, Drews M, Boland T, LaBerge M. Effects of the sample preparation temperature on the nanostructure of compression moulded ultrahigh molecular weight polyethylene. Proc Inst Mech Eng H. 2002; 216(2):123-33.
        View in: PubMed
      38. Ho, S.P. and Friedman, R.J. and LaBerge, M. Critical Reviews in Biomedical Engineering. Failure analysis of anatomic porous hip replacement (APR IIS). 1998; 26(5).
      39. Pullela S. V. Determination of the PULSTAR Reactor Neutron Energy Spectrum, Journal of Energy Conversion and Management. 1996.
      40. Sarma P. K., Sunita P. V. Interaction of Thermal-Radiation with Laminar Natural-Convection from a Horizontal Cylinder in Air, Warme und Stoffunbertragung-Thermo and Fluid Dynamics, 26(2), 65-69. 1991.
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