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    Thomas Lang, PhD

    SchoolUCSF School of Medicine
    Address185 Berry Street
    San Francisco CA 94143

       Awards and Honors
      NIH Center for Scientific Review, ZRG1-MOSS-C56 DP2, Director's New Innovator Award Study Section2014Editorial Reviewer
      American Institute of Medical and Biological Engineering2014Fellow
      Academy of Radiology Research2013Distinguished Investigator Award
      American Astronautical Society/NASA2013International Space Station Top Discoveries in Microgravity Award
      Journal of Bone and Mineral Research2013Associate Editor
      Osteoporosis International20132012 Citation Prize
      American Federation for Aging Research2012Member, Scientific Advisory Board
      Journal of Bone and Mineral Research2010 - 2012Editorial Board
      NIH Center for Scientific Review, ZRG1 DTCS-A81 Imaging Study Section2011Editorial Reviewer
      University of California, San Francisco2010Conflict of Interest Advisory Committee Chairman
      NIH Center for Scientific Review2009 - 2013Skeletal Biology, Structure and Regeneration Study Section
      National Space Biomedical Research Institute2008 - 2012Musculoskeletal Alterations Team Leader
      American Society of Bone and Mineral Research2007Bridge Funding Grant Award
      Faculty of Medicine, University of Buenos Aires2004Visiting Professor
      World Congress on Osteoporosis1995Young Investigator Award

      Thomas F. Lang, PhD, is a Professor in Residence, a faculty member of the Musculoskeletal Quantitative Imaging Research Group, and he leads the Musculoskeletal CT Imaging Research Group at the University of California, San Francisco. Since 2010, Dr. Lang has served as Chair of the UCSF Chancellor’s Conflict of Interest Advisory Committee. Clinically, Dr. Lang and his colleagues are establishing a research program using CT and PET/CT to measure physical traits, muscle size, adiposity, and protein synthesis rate as markers of frailty. Dr. Lang obtained his BA in Chemistry at the University of Chicago in 1983, and completed his PhD in Chemistry at the University of California, Berkeley in 1990, followed by a postdoctoral fellowship in Radiology Imaging at UCSF in 1992.

      In the beginning of Dr. Lang’s career at UCSF, his research focus was to develop quantitative analytic methods to characterize skeletal density, geometry and indices of strength from volumetric CT scans of the hip and spine. With the growth of his research group, Dr. Lang and his group have continued a robust program in methods development, integrating density and structured analysis with serial image registration to improve sensitivity for detecting changes in longitudinal measures, and finite element modeling in order to understand how density and structure measures of bones are related to bone strength, stiffness, and factures.

      Presently, Dr. Lang is collaborating with NASA Johnson Space Center’s using quantitative assessments to study the effect of long-duration spaceflight and prolonged mechanical unloading on skeletal density, structure, and strength. Dr. Lang has served as Principal Investigator and Co-Principal Investigator of many NIH grants. He has 97 published articles, and 7 book chapters.

      Osteoporosis and Musculoskeletal

      Bone aging, quantitative computed tomography, sarcopenia

      Professional Interests:
      Osteoporosis, computed tomography, bone mineral density measurements, CT and PET/CT imaging in the study of the human biology of the musculoskeletal system

      Education and Training:
      • Bachelor of Art: University of Chicago - Chemistry
      • Doctor of Philosophy: University of California, Berkeley - Chemistry
      • Postdoctoral Fellowship: University of California, San Francisco - Radiology Imaging
      • UCSF/Coro Leadership Collaborative Program

      Osteoporosis, computed tomography, bone mineral density measurements, CT and PET/CT imaging in the study of the human biology of the musculoskeletal system.

       ORNG Applications 
       In The News
       Awarded Grants
       Global Health

      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Harris TB, Song X, Reinders I, Lang TF, Garcia ME, Siggeirsdottir K, Sigurdsson S, Gudnason V, Eiriksdottir G, Sigurdsson G, Steingrimsdottir L, Aspelund T, Brouwer IA, Murphy RA. Plasma phospholipid fatty acids and fish-oil consumption in relation to osteoporotic fracture risk in older adults: the Age, Gene/Environment Susceptibility Study. Am J Clin Nutr. 2015 Mar 18.
        View in: PubMed
      2. Koster A, Murphy RA, Eiriksdottir G, Aspelund T, Sigurdsson S, Lang TF, Gudnason V, Launer LJ, Harris TB. Fat distribution and mortality: The AGES-Reykjavik study. Obesity (Silver Spring). 2015 Apr; 23(4):893-7.
        View in: PubMed
      3. Reinders I, Murphy RA, Song X, Visser M, Cotch MF, Lang TF, Garcia ME, Launer LJ, Siggeirsdottir K, Eiriksdottir G, Jonsson PV, Gudnason V, Harris TB, Brouwer IA. Polyunsaturated fatty acids in relation to incident mobility disability and decline in gait speed; the Age, Gene/Environment Susceptibility-Reykjavik Study. Eur J Clin Nutr. 2015 Apr; 69(4):489-93.
        View in: PubMed
      4. Heilmeier U, Carpenter DR, Patsch JM, Harnish R, Joseph GB, Burghardt AJ, Baum T, Schwartz AV, Lang TF, Link TM. Volumetric femoral BMD, bone geometry, and serum sclerostin levels differ between type 2 diabetic postmenopausal women with and without fragility fractures. Osteoporos Int. 2015 Apr; 26(4):1283-93.
        View in: PubMed
      5. Kiel DP, Hannan MT, Barton BA, Bouxsein ML, Sisson E, Lang T, Allaire B, Dewkett D, Carroll D, Magaziner J, Shane E, Leary ET, Zimmerman S, Rubin C. Low Magnitude Mechanical Stimulation to Improve Bone Density in Persons of Advanced Age: A Randomized, Placebo-Controlled Trial. J Bone Miner Res. 2015 Jan 8.
        View in: PubMed
      6. Ma YH, Schwartz AV, Sigurdsson S, Hue TF, Lang TF, Harris TB, Rosen CJ, Vittinghoff E, Eiriksdottir G, Hauksdottir AM, Siggeirsdottir K, Sigurdsson G, Oskarsdottir D, Napoli N, Palermo L, Gudnason V, Li X. Circulating sclerostin associated with vertebral bone marrow fat in older men but not women. J Clin Endocrinol Metab. 2014 Dec; 99(12):E2584-90.
        View in: PubMed
      7. Bonaretti S, Carpenter RD, Saeed I, Burghardt AJ, Yu L, Bruesewitz M, Khosla S, Lang T. Novel anthropomorphic hip phantom corrects systemic interscanner differences in proximal femoral vBMD. Phys Med Biol. 2014 Nov 24; 59(24):7819-7834.
        View in: PubMed
      8. Carpenter RD, Saeed I, Bonaretti S, Schreck C, Keyak JH, Streeper T, Harris TB, Lang TF. Inter-scanner differences in in vivo QCT measurements of the density and strength of the proximal femur remain after correction with anthropomorphic standardization phantoms. Med Eng Phys. 2014 Oct; 36(10):1225-32.
        View in: PubMed
      9. Lang TF, Saeed IH, Streeper T, Carballido-Gamio J, Harnish RJ, Frassetto LA, Lee SM, Sibonga JD, Keyak JH, Spiering BA, Grodsinsky CM, Bloomberg JJ, Cavanagh PR. Spatial heterogeneity in the response of the proximal femur to two lower-body resistance exercise regimens. J Bone Miner Res. 2014 Jun; 29(6):1337-45.
        View in: PubMed PMC4029859
      10. Link TM, Lang TF. Axial QCT: clinical applications and new developments. J Clin Densitom. 2014 Oct-Dec; 17(4):438-48.
        View in: PubMed
      11. Harnish R, Prevrhal S, Alavi A, Zaidi H, Lang TF. The effect of metal artefact reduction on CT-based attenuation correction for PET imaging in the vicinity of metallic hip implants: a phantom study. Ann Nucl Med. 2014 Jul; 28(6):540-50.
        View in: PubMed PMC4101148
      12. Carballido-Gamio J, Harnish R, Saeed I, Streeper T, Sigurdsson S, Amin S, Atkinson EJ, Therneau TM, Siggeirsdottir K, Cheng X, Melton LJ, Keyak JH, Gudnason V, Khosla S, Harris TB, Lang TF. Structural patterns of the proximal femur in relation to age and hip fracture risk in women. Bone. 2013 Nov; 57(1):290-9.
        View in: PubMed PMC3809121
      13. Keyak JH, Sigurdsson S, Karlsdottir GS, Oskarsdottir D, Sigmarsdottir A, Kornak J, Harris TB, Sigurdsson G, Jonsson BY, Siggeirsdottir K, Eiriksdottir G, Gudnason V, Lang TF. Effect of finite element model loading condition on fracture risk assessment in men and women: the AGES-Reykjavik study. Bone. 2013 Nov; 57(1):18-29.
        View in: PubMed PMC3786229
      14. Murphy RA, Register TC, Shively CA, Carr JJ, Ge Y, Heilbrun ME, Cummings SR, Koster A, Nevitt MC, Satterfield S, Tylvasky FA, Strotmeyer ES, Newman AB, Simonsick EM, Scherzinger A, Goodpaster BH, Launer LJ, Eiriksdottir G, Sigurdsson S, Sigurdsson G, Gudnason V, Lang TF, Kritchevsky SB, Harris TB. Adipose tissue density, a novel biomarker predicting mortality risk in older adults. J Gerontol A Biol Sci Med Sci. 2014 Jan; 69(1):109-17.
        View in: PubMed PMC3859360
      15. Carrère P, Atallah A, Kelly-Irving M, Lang T, Inamo J. [Television viewing and cardiovascular risk behaviors in the adult population of the French West Indies]. Ann Cardiol Angeiol (Paris). 2013 Jun; 62(3):161-5.
        View in: PubMed
      16. Schwartz AV, Sigurdsson S, Hue TF, Lang TF, Harris TB, Rosen CJ, Vittinghoff E, Siggeirsdottir K, Sigurdsson G, Oskarsdottir D, Shet K, Palermo L, Gudnason V, Li X. Vertebral bone marrow fat associated with lower trabecular BMD and prevalent vertebral fracture in older adults. J Clin Endocrinol Metab. 2013 Jun; 98(6):2294-300.
        View in: PubMed PMC3667265
      17. Rianon NJ, Lang TF, Siggeirsdottir K, Sigurdsson G, Eiriksdottir G, Sigurdsson S, Jonsson BY, Garcia M, Yu B, Kapadia AS, Taylor WC, Selwyn BJ, Gudnason V, Launer LJ, Harris TB. Fracture risk assessment in older adults using a combination of selected quantitative computed tomography bone measures: a subanalysis of the Age, Gene/Environment Susceptibility-Reykjavik Study. J Clin Densitom. 2014 Jan-Mar; 17(1):25-31.
        View in: PubMed
      18. Cohen A, Dempster DW, Recker RR, Lappe JM, Zhou H, Zwahlen A, Müller R, Zhao B, Guo X, Lang T, Saeed I, Liu XS, Guo XE, Cremers S, Rosen CJ, Stein EM, Nickolas TL, McMahon DJ, Young P, Shane E. Abdominal fat is associated with lower bone formation and inferior bone quality in healthy premenopausal women: a transiliac bone biopsy study. J Clin Endocrinol Metab. 2013 Jun; 98(6):2562-72.
        View in: PubMed PMC3667251
      19. Cammin-Nowak S, Helbig-Lang S, Lang T, Gloster AT, Fehm L, Gerlach AL, Ströhle A, Deckert J, Kircher T, Hamm AO, Alpers GW, Arolt V, Wittchen HU. Specificity of homework compliance effects on treatment outcome in CBT: evidence from a controlled trial on panic disorder and agoraphobia. J Clin Psychol. 2013 Jun; 69(6):616-29.
        View in: PubMed
      20. Carballido-Gamio J, Harnish R, Saeed I, Streeper T, Sigurdsson S, Amin S, Atkinson EJ, Therneau TM, Siggeirsdottir K, Cheng X, Melton LJ, Keyak J, Gudnason V, Khosla S, Harris TB, Lang TF. Proximal femoral density distribution and structure in relation to age and hip fracture risk in women. J Bone Miner Res. 2013 Mar; 28(3):537-46.
        View in: PubMed PMC3578081
      21. Leblanc A, Matsumoto T, Jones J, Shapiro J, Lang T, Shackelford L, Smith SM, Evans H, Spector E, Ploutz-Snyder R, Sibonga J, Keyak J, Nakamura T, Kohri K, Ohshima H. Bisphosphonates as a supplement to exercise to protect bone during long-duration spaceflight. Osteoporos Int. 2013 Jul; 24(7):2105-14.
        View in: PubMed
      22. Cohen A, Lang TF, McMahon DJ, Liu XS, Guo XE, Zhang C, Stein EM, Dempster DW, Young P, Saeed I, Lappe JM, Recker RR, Shane E. Central QCT reveals lower volumetric BMD and stiffness in premenopausal women with idiopathic osteoporosis, regardless of fracture history. J Clin Endocrinol Metab. 2012 Nov; 97(11):4244-52.
        View in: PubMed PMC3485589
      23. Lang T. Sarcopenia, edited by Alfredo Cruz-Jentoft and John E. Morley. Imaging of Skeletal Muscle. 2012; 193-204.
      24. Latus J, Ulmer C, Fritz P, Rettenmaier B, Biegger D, Lang T, Ott G, Scharpf C, Kimmel M, Steurer W, Alscher MD, Braun N. Encapsulating peritoneal sclerosis: a rare, serious but potentially curable complication of peritoneal dialysis-experience of a referral centre in Germany. Nephrol Dial Transplant. 2013 Apr; 28(4):1021-30.
        View in: PubMed
      25. Liu CT, Karasik D, Zhou Y, Hsu YH, Genant HK, Broe KE, Lang TF, Samelson EJ, Demissie S, Bouxsein ML, Cupples LA, Kiel DP. Heritability of prevalent vertebral fracture and volumetric bone mineral density and geometry at the lumbar spine in three generations of the Framingham study. J Bone Miner Res. 2012 Apr; 27(4):954-8.
        View in: PubMed PMC3375687
      26. Johannesdottir F, Aspelund T, Siggeirsdottir K, Jonsson BY, Mogensen B, Sigurdsson S, Harris TB, Gudnason VG, Lang TF, Sigurdsson G. Mid-thigh cortical bone structural parameters, muscle mass and strength, and association with lower limb fractures in older men and women (AGES-Reykjavik Study). Calcif Tissue Int. 2012 May; 90(5):354-64.
        View in: PubMed
      27. Samelson EJ, Christiansen BA, Demissie S, Broe KE, Louie-Gao Q, Cupples LA, Roberts BJ, Manoharam R, D'Agostino J, Lang T, Kiel DP, Bouxsein ML. QCT measures of bone strength at the thoracic and lumbar spine: the Framingham Study. J Bone Miner Res. 2012 Mar; 27(3):654-63.
        View in: PubMed PMC3728822
      28. R. Harnish, T. Streeper, I. Saeed, C. Schreck, S. Dannoon, J. Slater, J. Blecha, H. VanBrocklin, M. Hernandez-Pampaloni, R. Hawkins, Y. Seo, G. Sayre and T. Lang. Journal of Molecular Imaging and Dynamics. Quantification of changes in skeletal muscle amino acid kinetics in adult humans in response to exercise via positron-emission tomography with L-[methyl-11C]methionine. 2012; 2(1):103.
      29. Rianon NJ, Lang TF, Sigurdsson G, Eiriksdottir G, Sigurdsson S, Garcia M, Pajala S, Koster A, Yu B, Selwyn BJ, Taylor WC, Kapadia AS, Gudnason V, Launer LJ, Harris TB. Lifelong physical activity in maintaining bone strength in older men and women of the Age, Gene/Environment Susceptibility-Reykjavik Study. Osteoporos Int. 2012 Sep; 23(9):2303-12.
        View in: PubMed
      30. Lang TF, Sigurdsson S, Karlsdottir G, Oskarsdottir D, Sigmarsdottir A, Chengshi J, Kornak J, Harris TB, Sigurdsson G, Jonsson BY, Siggeirsdottir K, Eiriksdottir G, Gudnason V, Keyak JH. Age-related loss of proximal femoral strength in elderly men and women: the Age Gene/Environment Susceptibility Study--Reykjavik. Bone. 2012 Mar; 50(3):743-8.
        View in: PubMed PMC3278586
      31. Walker MD, Saeed I, McMahon DJ, Udesky J, Liu G, Lang T, Bilezikian JP. Volumetric bone mineral density at the spine and hip in Chinese American and White women. Osteoporos Int. 2012 Oct; 23(10):2499-506.
        View in: PubMed PMC3552556
      32. Rieder F, Hahn P, Finsterhoelzl L, Schleder S, Wolf A, Dirmeier A, Lopez R, Shen B, Rogler G, Klebl F, Lang T. Clinical utility of anti-glycan antibodies in pediatric Crohn's disease in comparison with an adult cohort. Inflamm Bowel Dis. 2012 Jul; 18(7):1221-31.
        View in: PubMed
      33. Lang TF. The bone-muscle relationship in men and women. J Osteoporos. 2011; 2011:702735.
        View in: PubMed PMC3189615
      34. Javaid MK, Prieto-Alhambra D, Lui LY, Cawthon P, Arden NK, Lang T, Lane NE, Orwoll E, Barrett-Conner E, Nevitt MC, Cooper C, Cummings SR. Self-reported weight at birth predicts measures of femoral size but not volumetric BMD in eldery men: MrOS. J Bone Miner Res. 2011 Aug; 26(8):1802-7.
        View in: PubMed PMC3809067
      35. Lang T, Justenhoven C, Winter S, Baisch C, Hamann U, Harth V, Ko YD, Rabstein S, Spickenheuer A, Pesch B, Brüning T, Schwab M, Brauch H. The earwax-associated SNP c.538G>A (G180R) in ABCC11 is not associated with breast cancer risk in Europeans. Breast Cancer Res Treat. 2011 Oct; 129(3):993-9.
        View in: PubMed
      36. Keyak JH, Sigurdsson S, Karlsdottir G, Oskarsdottir D, Sigmarsdottir A, Zhao S, Kornak J, Harris TB, Sigurdsson G, Jonsson BY, Siggeirsdottir K, Eiriksdottir G, Gudnason V, Lang TF. Male-female differences in the association between incident hip fracture and proximal femoral strength: a finite element analysis study. Bone. 2011 Jun 1; 48(6):1239-45.
        View in: PubMed PMC3095704
      37. Streeper T, Cavanagh TR, Hanson AM, Carpenter RD,Saeed I, Kornak J, Frassetto L, Grodsinsky C, Funk J, Lee SMC, Spiering BA, Bloomberg J, Mulavara A, Sibonga J, Lang T. Acta Astronauta. Development of an integrated countermeasure device for use in long-duration spaceflight. 2011; 68(11-12):2029-2037.
      38. Carpenter RD, Sigurdsson S, Zhao S, Lu Y, Eiriksdottir G, Sigurdsson G, Jonsson BY, Prevrhal S, Harris TB, Siggeirsdottir K, Guðnason V, Lang TF. Effects of age and sex on the strength and cortical thickness of the femoral neck. Bone. 2011 Apr 1; 48(4):741-7.
        View in: PubMed PMC3075958
      39. Zmuda JM, Yerges-Armstrong LM, Moffett SP, Klei L, Kammerer CM, Roeder K, Cauley JA, Kuipers A, Ensrud KE, Nestlerode CS, Hoffman AR, Lewis CE, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES. Genetic analysis of vertebral trabecular bone density and cross-sectional area in older men. Osteoporos Int. 2011 Apr; 22(4):1079-90.
        View in: PubMed PMC3691107
      40. Liu XS, Cohen A, Shane E, Yin PT, Stein EM, Rogers H, Kokolus SL, McMahon DJ, Lappe JM, Recker RR, Lang T, Guo XE. Bone density, geometry, microstructure, and stiffness: Relationships between peripheral and central skeletal sites assessed by DXA, HR-pQCT, and cQCT in premenopausal women. J Bone Miner Res. 2010 Oct; 25(10):2229-38.
        View in: PubMed PMC3128822
      41. Schafer AL, Vittinghoff E, Lang TF, Sellmeyer DE, Harris TB, Kanaya AM, Strotmeyer ES, Cawthon PM, Cummings SR, Tylavsky FA, Scherzinger AL, Schwartz AV. Fat infiltration of muscle, diabetes, and clinical fracture risk in older adults. J Clin Endocrinol Metab. 2010 Nov; 95(11):E368-72.
        View in: PubMed PMC2968723
      42. Zhao Q, Li W, Li C, Chu PW, Kornak J, Lang TF, Fang J, Lu Y. A statistical method (cross-validation) for bone loss region detection after spaceflight. Australas Phys Eng Sci Med. 2010 Jun; 33(2):163-9.
        View in: PubMed PMC2917547
      43. Kiel DP, Hannan MT, Barton BA, Bouxsein ML, Lang TF, Brown KM, Shane E, Magaziner J, Zimmerman S, Rubin CT. Insights from the conduct of a device trial in older persons: low magnitude mechanical stimulation for musculoskeletal health. Clin Trials. 2010 Aug; 7(4):354-67.
        View in: PubMed PMC3136380
      44. Lang TF. Quantitative computed tomography. Radiol Clin North Am. 2010 May; 48(3):589-600.
        View in: PubMed
      45. Lang T, Cauley JA, Tylavsky F, Bauer D, Cummings S, Harris TB. Computed tomographic measurements of thigh muscle cross-sectional area and attenuation coefficient predict hip fracture: the health, aging, and body composition study. J Bone Miner Res. 2010 Mar; 25(3):513-9.
        View in: PubMed PMC3153392
      46. Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Ensrud KE, Nestlerode CS, Lewis C, Lang TF, Barrett-Connor E, Moffett SP, Hoffman AR, Ferrell RE, Orwoll ES, Zmuda JM. Candidate gene analysis of femoral neck trabecular and cortical volumetric bone mineral density in older men. J Bone Miner Res. 2010 Feb; 25(2):330-8.
        View in: PubMed PMC3153388
      47. Chaganti RK, Parimi N, Lang T, Orwoll E, Stefanick ML, Nevitt M, Lane NE. Bone mineral density and prevalent osteoarthritis of the hip in older men for the Osteoporotic Fractures in Men (MrOS) Study Group. Osteoporos Int. 2010 Aug; 21(8):1307-16.
        View in: PubMed PMC3354730
      48. Carpenter RD, LeBlanc AD, Evans H, Sibonga JD, Lang TF. Long-term changes in the density and structure of the human hip and spine after long-duration spaceflight. Acta Astronautica. 2010; 67(1-2):71-81.
      49. Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. J Bone Miner Res. 2009 Dec; 24(12):2039-49.
        View in: PubMed PMC2791518
      50. Eastell R, Lang T, Boonen S, Cummings S, Delmas PD, Cauley JA, Horowitz Z, Kerzberg E, Bianchi G, Kendler D, Leung P, Man Z, Mesenbrink P, Eriksen EF, Black DM. Effect of once-yearly zoledronic acid on the spine and hip as measured by quantitative computed tomography: results of the HORIZON Pivotal Fracture Trial. Osteoporos Int. 2010 Jul; 21(7):1277-85.
        View in: PubMed
      51. Chevalier Y, Quek E, Borah B, Gross G, Stewart J, Lang T, Zysset P. Biomechanical effects of teriparatide in women with osteoporosis treated previously with alendronate and risedronate: results from quantitative computed tomography-based finite element analysis of the vertebral body. Bone. 2010 Jan; 46(1):41-8.
        View in: PubMed
      52. Lang T, Streeper T, Cawthon P, Baldwin K, Taaffe DR, Harris TB. Sarcopenia: etiology, clinical consequences, intervention, and assessment. Osteoporos Int. 2010 Apr; 21(4):543-59.
        View in: PubMed PMC2832869
      53. O'Meara WP, Lang T. Malaria vaccine trial endpoints - bridging the gaps between trial design, public health and the next generation of vaccines. Parasite Immunol. 2009 Sep; 31(9):574-81.
        View in: PubMed
      54. Saeed I, Carpenter RD, Leblanc AD, Li J, Keyak JH, Sibonga JD, Lang TF. Quantitative computed tomography reveals the effects of race and sex on bone size and trabecular and cortical bone density. J Clin Densitom. 2009 Jul-Sep; 12(3):330-6.
        View in: PubMed
      55. Li W, Kornak J, Harris TB, Keyak J, Li C, Lu Y, Cheng X, Lang T. Bone fracture risk estimation based on image similarity. Bone. 2009 Sep; 45(3):560-7.
        View in: PubMed PMC2896043
      56. Li W, Kornak J, Harris T, Keyak J, Li C, Lu Y, Cheng X, Lang T. Identify fracture-critical regions inside the proximal femur using statistical parametric mapping. Bone. 2009 Apr; 44(4):596-602.
        View in: PubMed PMC2656587
      57. Hyder JA, Allison MA, Wong N, Papa A, Lang TF, Sirlin C, Gapstur SM, Ouyang P, Carr JJ, Criqui MH. Association of coronary artery and aortic calcium with lumbar bone density: the MESA Abdominal Aortic Calcium Study. Am J Epidemiol. 2009 Jan 15; 169(2):186-94.
        View in: PubMed PMC2727254
      58. Taaffe DR, Henwood TR, Nalls MA, Walker DG, Lang TF, Harris TB. Alterations in muscle attenuation following detraining and retraining in resistance-trained older adults. Gerontology. 2009; 55(2):217-23.
        View in: PubMed PMC2756799
      59. Keyak JH, Koyama AK, LeBlanc A, Lu Y, Lang TF. Reduction in proximal femoral strength due to long-duration spaceflight. Bone. 2009 Mar; 44(3):449-53.
        View in: PubMed
      60. Miller PD, Delmas PD, Lindsay R, Watts NB, Luckey M, Adachi J, Saag K, Greenspan SL, Seeman E, Boonen S, Meeves S, Lang TF, Bilezikian JP. Early responsiveness of women with osteoporosis to teriparatide after therapy with alendronate or risedronate. J Clin Endocrinol Metab. 2008 Oct; 93(10):3785-93.
        View in: PubMed
      61. Black DM, Bouxsein ML, Marshall LM, Cummings SR, Lang TF, Cauley JA, Ensrud KE, Nielson CM, Orwoll ES. Proximal femoral structure and the prediction of hip fracture in men: a large prospective study using QCT. J Bone Miner Res. 2008 Aug; 23(8):1326-33.
        View in: PubMed PMC2680175
      62. Rivière S, Schwoebel V, Lapierre-Duval K, Guinard A, Gardette V, Lang T. Predictors of symptoms of post-traumatic stress disorder after the AZF chemical factory explosion on 21 September 2001, in Toulouse, France. J Epidemiol Community Health. 2008 May; 62(5):455-60.
        View in: PubMed
      63. Prevrhal S, Shepherd JA, Faulkner KG, Gaither KW, Black DM, Lang TF. Comparison of DXA hip structural analysis with volumetric QCT. J Clin Densitom. 2008 Apr-Jun; 11(2):232-6.
        View in: PubMed
      64. Lang T, Koyama A, Li C, Li J, Lu Y, Saeed I, Gazze E, Keyak J, Harris T, Cheng X. Pelvic body composition measurements by quantitative computed tomography: association with recent hip fracture. Bone. 2008 Apr; 42(4):798-805.
        View in: PubMed
      65. Marshall LM, Zmuda JM, Chan BK, Barrett-Connor E, Cauley JA, Ensrud KE, Lang TF, Orwoll ES. Race and ethnic variation in proximal femur structure and BMD among older men. J Bone Miner Res. 2008 Jan; 23(1):121-30.
        View in: PubMed PMC2663587
      66. Mackey DC, Eby JG, Harris F, Taaffe DR, Cauley JA, Tylavsky FA, Harris TB, Lang TF, Cummings SR. Prediction of clinical non-spine fractures in older black and white men and women with volumetric BMD of the spine and areal BMD of the hip: the Health, Aging, and Body Composition Study*. J Bone Miner Res. 2007 Dec; 22(12):1862-8.
        View in: PubMed
      67. Sibonga JD, Evans HJ, Sung HG, Spector ER, Lang TF, Oganov VS, Bakulin AV, Shackelford LC, LeBlanc AD. Recovery of spaceflight-induced bone loss: bone mineral density after long-duration missions as fitted with an exponential function. Bone. 2007 Dec; 41(6):973-8.
        View in: PubMed
      68. Li W, Kezele I, Collins DL, Zijdenbos A, Keyak J, Kornak J, Koyama A, Saeed I, Leblanc A, Harris T, Lu Y, Lang T. Voxel-based modeling and quantification of the proximal femur using inter-subject registration of quantitative CT images. Bone. 2007 Nov; 41(5):888-95.
        View in: PubMed PMC2080679
      69. Lang TF. What do we know about fracture risk in long-duration spaceflight? J Musculoskelet Neuronal Interact. 2006 Oct-Dec; 6(4):319-21.
        View in: PubMed
      70. Lang TF, Leblanc AD, Evans HJ, Lu Y. Adaptation of the proximal femur to skeletal reloading after long-duration spaceflight. J Bone Miner Res. 2006 Aug; 21(8):1224-30.
        View in: PubMed
      71. Marshall LM, Lang TF, Lambert LC, Zmuda JM, Ensrud KE, Orwoll ES. Dimensions and volumetric BMD of the proximal femur and their relation to age among older U.S. men. J Bone Miner Res. 2006 Aug; 21(8):1197-206.
        View in: PubMed
      72. Cheng X, Li J, Lu Y, Keyak J, Lang T. Proximal femoral density and geometry measurements by quantitative computed tomography: association with hip fracture. Bone. 2007 Jan; 40(1):169-74.
        View in: PubMed
      73. Guglielmi G, van Kuijk C, Li J, Meta MD, Scillitani A, Lang TF. Influence of anthropometric parameters and bone size on bone mineral density using volumetric quantitative computed tomography and dual X-ray absorptiometry at the hip. Acta Radiol. 2006 Jul; 47(6):574-80.
        View in: PubMed
      74. Sigurdsson G, Aspelund T, Chang M, Jonsdottir B, Sigurdsson S, Eiriksdottir G, Gudmundsson A, Harris TB, Gudnason V, Lang TF. Increasing sex difference in bone strength in old age: The Age, Gene/Environment Susceptibility-Reykjavik study (AGES-REYKJAVIK). Bone. 2006 Sep; 39(3):644-51.
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      75. Meta M, Lu Y, Keyak JH, Lang T. Young-elderly differences in bone density, geometry and strength indices depend on proximal femur sub-region: a cross sectional study in Caucasian-American women. Bone. 2006 Jul; 39(1):152-8.
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      76. Li W, Sode M, Saeed I, Lang T. Automated registration of hip and spine for longitudinal QCT studies: integration with 3D densitometric and structural analysis. Bone. 2006 Feb; 38(2):273-9.
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      77. Black DM, Bilezikian JP, Ensrud KE, Greenspan SL, Palermo L, Hue T, Lang TF, McGowan JA, Rosen CJ. One year of alendronate after one year of parathyroid hormone (1-84) for osteoporosis. N Engl J Med. 2005 Aug 11; 353(6):555-65.
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      78. Inamo J, Malfatti S, Lang T, Atallah A, Inamo A, Larabi L, de Gaudemaris R. [Arterial hypertension in the French Caribbean regions: gender related differences]. Arch Mal Coeur Vaiss. 2005 Jul-Aug; 98(7-8):845-9.
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      79. Carpenter RD, Beaupré GS, Lang TF, Orwoll ES, Carter DR. New QCT analysis approach shows the importance of fall orientation on femoral neck strength. J Bone Miner Res. 2005 Sep; 20(9):1533-42.
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      80. Guglielmi G, Floriani I, Torri V, Li J, van Kuijk C, Genant HK, Lang TF. Effect of spinal degenerative changes on volumetric bone mineral density of the central skeleton as measured by quantitative computed tomography. Acta Radiol. 2005 May; 46(3):269-75.
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      81. Genant HK, Lang T, Fuerst T, Pinette KV, Zhou C, Thiebaud D, Diez-Perez A. Treatment with raloxifene for 2 years increases vertebral bone mineral density as measured by volumetric quantitative computed tomography. Bone. 2004 Nov; 35(5):1164-8.
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      82. Wong M, Papa A, Lang T, Hodis HN, Labree L, Detrano R. Validation of thoracic quantitative computed tomography as a method to measure bone mineral density. Calcif Tissue Int. 2005 Jan; 76(1):7-10.
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      83. Lian KC, Lang TF, Keyak JH, Modin GW, Rehman Q, Do L, Lane NE. Differences in hip quantitative computed tomography (QCT) measurements of bone mineral density and bone strength between glucocorticoid-treated and glucocorticoid-naive postmenopausal women. Osteoporos Int. 2005 Jun; 16(6):642-50.
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      84. Niemi M, Schaeffeler E, Lang T, Fromm MF, Neuvonen M, Kyrklund C, Backman JT, Kerb R, Schwab M, Neuvonen PJ, Eichelbaum M, Kivistö KT. High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1). Pharmacogenetics. 2004 Jul; 14(7):429-40.
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      85. Lang T, LeBlanc A, Evans H, Lu Y, Genant H, Yu A. Cortical and trabecular bone mineral loss from the spine and hip in long-duration spaceflight. J Bone Miner Res. 2004 Jun; 19(6):1006-12.
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      86. Carbone LD, Tylavsky FA, Cauley JA, Harris TB, Lang TF, Bauer DC, Barrow KD, Kritchevsky SB. Association between bone mineral density and the use of nonsteroidal anti-inflammatory drugs and aspirin: impact of cyclooxygenase selectivity. J Bone Miner Res. 2003 Oct; 18(10):1795-802.
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      87. Black DM, Greenspan SL, Ensrud KE, Palermo L, McGowan JA, Lang TF, Garnero P, Bouxsein ML, Bilezikian JP, Rosen CJ. The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis. N Engl J Med. 2003 Sep 25; 349(13):1207-15.
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      88. Taaffe DR, Lang TF, Fuerst T, Cauley JA, Nevitt MC, Harris TB. Sex- and race-related differences in cross-sectional geometry and bone density of the femoral mid-shaft in older adults. Ann Hum Biol. 2003 May-Jun; 30(3):329-46.
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      89. Taaffe DR, Lang TF, Harris TB. Poor correlation of mid-femoral measurements by CT and hip measurements by DXA in the elderly. Aging Clin Exp Res. 2003 Apr; 15(2):131-5.
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      90. Tylavsky FA, Lohman TG, Dockrell M, Lang T, Schoeller DA, Wan JY, Fuerst T, Cauley JA, Nevitt M, Harris TB. Comparison of the effectiveness of 2 dual-energy X-ray absorptiometers with that of total body water and computed tomography in assessing changes in body composition during weight change. Am J Clin Nutr. 2003 Feb; 77(2):356-63.
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      91. Rehman Q, Lang TF, Arnaud CD, Modin GW, Lane NE. Daily treatment with parathyroid hormone is associated with an increase in vertebral cross-sectional area in postmenopausal women with glucocorticoid-induced osteoporosis. Osteoporos Int. 2003 Jan; 14(1):77-81.
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      92. Guglielmi G, Lang TF. Quantitative computed tomography. Semin Musculoskelet Radiol. 2002 Sep; 6(3):219-27.
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      93. Snijder MB, Visser M, Dekker JM, Seidell JC, Fuerst T, Tylavsky F, Cauley J, Lang T, Nevitt M, Harris TB. The prediction of visceral fat by dual-energy X-ray absorptiometry in the elderly: a comparison with computed tomography and anthropometry. Int J Obes Relat Metab Disord. 2002 Jul; 26(7):984-93.
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      94. Rehman Q, Lang T, Modin G, Lane NE. Quantitative computed tomography of the lumbar spine, not dual x-ray absorptiometry, is an independent predictor of prevalent vertebral fractures in postmenopausal women with osteopenia receiving long-term glucocorticoid and hormone-replacement therapy. Arthritis Rheum. 2002 May; 46(5):1292-7.
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      95. Lang TF, Guglielmi G, van Kuijk C, De Serio A, Cammisa M, Genant HK. Measurement of bone mineral density at the spine and proximal femur by volumetric quantitative computed tomography and dual-energy X-ray absorptiometry in elderly women with and without vertebral fractures. Bone. 2002 Jan; 30(1):247-50.
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      96. Taaffe DR, Cauley JA, Danielson M, Nevitt MC, Lang TF, Bauer DC, Harris TB. Race and sex effects on the association between muscle strength, soft tissue, and bone mineral density in healthy elders: the Health, Aging, and Body Composition Study. J Bone Miner Res. 2001 Jul; 16(7):1343-52.
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      97. Salamone LM, Fuerst T, Visser M, Kern M, Lang T, Dockrell M, Cauley JA, Nevitt M, Tylavsky F, Lohman TG. Measurement of fat mass using DEXA: a validation study in elderly adults. J Appl Physiol (1985). 2000 Jul; 89(1):345-52.
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      98. Genant HK, Gordon C, Jiang Y, Link TM, Hans D, Majumdar S, Lang TF. Advanced imaging of the macrostructure and microstructure of bone. Horm Res. 2000; 54 Suppl 1:24-30.
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      99. Visser M, Fuerst T, Lang T, Salamone L, Harris TB. Validity of fan-beam dual-energy X-ray absorptiometry for measuring fat-free mass and leg muscle mass. Health, Aging, and Body Composition Study--Dual-Energy X-ray Absorptiometry and Body Composition Working Group. J Appl Physiol (1985). 1999 Oct; 87(4):1513-20.
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      100. Genant HK, Gordon C, Jiang Y, Lang TF, Link TM, Majumdar S. Advanced imaging of bone macro and micro structure. Bone. 1999 Jul; 25(1):149-52.
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      101. Lang TF, Li J, Harris ST, Genant HK. Assessment of vertebral bone mineral density using volumetric quantitative CT. J Comput Assist Tomogr. 1999 Jan-Feb; 23(1):130-7.
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      102. Lang TF, Augat P, Lane NE, Genant HK. Trochanteric hip fracture: strong association with spinal trabecular bone mineral density measured with quantitative CT. Radiology. 1998 Nov; 209(2):525-30.
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      103. Augat P, Gordon CL, Lang TF, Iida H, Genant HK. Accuracy of cortical and trabecular bone measurements with peripheral quantitative computed tomography (pQCT). Phys Med Biol. 1998 Oct; 43(10):2873-83.
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      104. Majumdar S, Kothari M, Augat P, Newitt DC, Link TM, Lin JC, Lang T, Lu Y, Genant HK. High-resolution magnetic resonance imaging: three-dimensional trabecular bone architecture and biomechanical properties. Bone. 1998 May; 22(5):445-54.
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      105. Lang T, Augat P, Majumdar S, Ouyang X, Genant HK. Noninvasive assessment of bone density and structure using computed tomography and magnetic resonance. Bone. 1998 May; 22(5 Suppl):149S-153S.
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      106. Lang TF. Summary of research issues in imaging and noninvasive bone measurement. Bone. 1998 May; 22(5 Suppl):159S-161S.
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      107. Augat P, Fan B, Lane NE, Lang TF, LeHir P, Lu Y, Uffmann M, Genant HK. Assessment of bone mineral at appendicular sites in females with fractures of the proximal femur. Bone. 1998 Apr; 22(4):395-402.
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      108. Augat P, Link T, Lang TF, Lin JC, Majumdar S, Genant HK. Anisotropy of the elastic modulus of trabecular bone specimens from different anatomical locations. Med Eng Phys. 1998 Mar; 20(2):124-31.
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      109. Gordon CL, Lang TF, Augat P, Genant HK. Image-based assessment of spinal trabecular bone structure from high-resolution CT images. Osteoporos Int. 1998; 8(4):317-25.
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      110. Link TM, Majumdar S, Lin JC, Augat P, Gould RG, Newitt D, Ouyang X, Lang TF, Mathur A, Genant HK. Assessment of trabecular structure using high resolution CT images and texture analysis. J Comput Assist Tomogr. 1998 Jan-Feb; 22(1):15-24.
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      111. Takada M, Wu CY, Lang TF, Genant HK. Vertebral fracture assessment using the lateral scoutview of computed tomography in comparison with radiographs. Osteoporos Int. 1998; 8(3):197-203.
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      112. Hans D, Fuerst T, Lang T, Majumdar S, Lu Y, Genant HK, Glüer C. How can we measure bone quality? Baillieres Clin Rheumatol. 1997 Aug; 11(3):495-515.
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      113. Ito M, Lang TF, Jergas M, Ohki M, Takada M, Nakamura T, Hayashi K, Genant HK. Spinal trabecular bone loss and fracture in American and Japanese women. Calcif Tissue Int. 1997 Aug; 61(2):123-8.
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      114. Lang TF, Keyak JH, Heitz MW, Augat P, Lu Y, Mathur A, Genant HK. Volumetric quantitative computed tomography of the proximal femur: precision and relation to bone strength. Bone. 1997 Jul; 21(1):101-8.
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      115. Lang T, Takada M, Gee R, Wu C, Li J, Hayashi-Clark C, Schoen S, March V, Genant HK. A preliminary evaluation of the lunar expert-XL for bone densitometry and vertebral morphometry. J Bone Miner Res. 1997 Jan; 12(1):136-43.
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      116. Guglielmi G, Schneider P, Lang TF, Giannatempo GM, Cammisa M, Genant HK. Quantitative computed tomography at the axial and peripheral skeleton. Eur Radiol. 1997; 7 Suppl 2:S32-42.
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      117. Genant HK, Engelke K, Fuerst T, Glüer CC, Grampp S, Harris ST, Jergas M, Lang T, Lu Y, Majumdar S, Mathur A, Takada M. Noninvasive assessment of bone mineral and structure: state of the art. J Bone Miner Res. 1996 Jun; 11(6):707-30.
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      118. Genant HK, Lang TF, Engelke K, Fuerst T, Glüer C, Majumdar S, Jergas M. Advances in the noninvasive assessment of bone density, quality, and structure. Calcif Tissue Int. 1996; 59 Suppl 1:S10-5.
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      119. Glüer CC, Engelke K, Lang TF, Grampp S, Genant HK. Quantitative computed tomography (QCT) of the lumbar spine and appendicular skeleton. Eur J Radiol. 1995 Sep; 20(3):173-8.
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      120. Brown JK, Hasegawa BH, Lang TF. Iterative concurrent reconstruction algorithms for emission computed tomography. Phys Med Biol. 1994 Jul; 39(7):1113-32.
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      121. Lang TF, Hasegawa BH, Liew SC, Brown JK, Blankespoor SC, Reilly SM, Gingold EL, Cann CE. Description of a prototype emission-transmission computed tomography imaging system. J Nucl Med. 1992 Oct; 33(10):1881-7.
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