Adrian Erlebacher, MD, PhD

Title(s)Professor, Laboratory Medicine
SchoolSchool of Medicine
Address513 Parnassus Avenue, MSB, #1057B
San Francisco CA 94117
Phone415-502-3583
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    Work in the Erlebacher laboratory lies at the intersection of immunology and reproductive biology. Historically, we have focused on the immunological paradox of fetomaternal tolerance - i.e., how the fetus and placenta avoid rejection by the maternal immune system during pregnancy - with one long-term goal being the application of underlying mechanisms to the induction of antigen-specific immune tolerance in the clinical arena. We also study how uterine quiescence is established and maintained during pregnancy, as well as the immunological and epigenetic pathways that control gestation length and parturition induction. These interweaving lines of investigation have implications for the pathogenesis of preterm labor, preeclampsia, early pregnancy failure, and other disorders of maternal/fetal health.

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    Immunological, epigenetic and developmental determinants of early pregnancy success
    NIH/NICHD P50HD112034Aug 1, 2023 - Apr 30, 2028
    Epigenetic of decidual inflammation
    NIH/NICHD P50HD112034 (Project 2)Aug 1, 2023 - Apr 30, 2028
    The IL-33/ILC2 axis in parturition
    NIH R01AI150191Jan 15, 2020 - Dec 31, 2024
    Role: Principal Investigator
    Epigenetic regulation of labor onset
    Burrough Wellcome Fund 1019789Jun 1, 2019 - Mar 31, 2023
    Epigenetics of uterine quiescence
    NIH R01AI143187Nov 8, 2018 - Oct 31, 2023
    Role: Principal Investigator
    Epigenetic regulation of decidual inflammation
    NIH R01AI106745Jun 1, 2013 - May 31, 2018
    Role: Principal Investigator
    Inflammation and immunity in the crucible of premalignancy
    NIH R01CA168755Apr 1, 2013 - Mar 31, 2019
    Role: Principal Investigator
    Dendritic cell behavior at the maternal/fetal interface
    NIH R01AI062980May 15, 2005 - Dec 31, 2010
    Role: Principal Investigator
    MATERNAL IMMUNE TOLERANCE TO THE ALLOGENEIC FETUS
    NIH K08AI001650Jul 1, 1999 - Jun 30, 2004
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Circumvention of luteolysis reveals parturition pathways in mice dependent upon innate type 2 immunity. Immunity. 2023 03 14; 56(3):606-619.e7. Siewiera J, McIntyre TI, Cautivo KM, Mahiddine K, Rideaux D, Molofsky AB, Erlebacher A. PMID: 36750100; PMCID: PMC10023352.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    2. Trophoblast antigens, fetal blood cell antigens, and the paradox of fetomaternal tolerance. J Exp Med. 2022 05 02; 219(5). Rizzuto G, Erlebacher A. PMID: 35416936; PMCID: PMC9011327.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    3. Establishment of fetomaternal tolerance through glycan-mediated B cell suppression. Nature. 2022 03; 603(7901):497-502. Rizzuto G, Brooks JF, Tuomivaara ST, McIntyre TI, Ma S, Rideaux D, Zikherman J, Fisher SJ, Erlebacher A. PMID: 35236989; PMCID: PMC9592526.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    4. Gene silencing by EZH2 suppresses TGF-β activity within the decidua to avert pregnancy-adverse wound healing at the maternal-fetal interface. Cell Rep. 2022 02 01; 38(5):110329. Osokine I, Siewiera J, Rideaux D, Ma S, Tsukui T, Erlebacher A. PMID: 35108527; PMCID: PMC8833843.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    5. Paul's Fundamental Immunology. Maternal-Fetal Immunology (Chapter 41). 2022; 1283-1324. Gabrielle Rizzuto and Adrian Erlebacher. .
    6. CD22/Lyn-mediated suppression of trophoblast antigen-specific B cells underlies fetomaternal tolerance. The Journal of Immunology. 2021 May 1; 206(1_Supplement):28.18-28.18. Rizzuto RG, Brooks BJ, Fisher FS, Zikherman ZJ, Erlebacher EA. .
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    7. Chapter 8 Immunology of the decidua. . 2021 Jan 1; 129-145. Osokine OI, Erlebacher EA. .
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    8. Myometrial leukocytes. Current Opinion in Physiology. 2020 Feb 1; 13:6-13. Siewiera SJ, Erlebacher EA. .
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    9. Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils. J Clin Invest. 2020 01 02; 130(1):389-403. Mahiddine K, Blaisdell A, Ma S, Créquer-Grandhomme A, Lowell CA, Erlebacher A. PMID: 31600172; PMCID: PMC6934192.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    10. H3K27me3 dynamics dictate evolving uterine states in pregnancy and parturition. J Clin Invest. 2018 01 02; 128(1):233-247. Nancy P, Siewiera J, Rizzuto G, Tagliani E, Osokine I, Manandhar P, Dolgalev I, Clementi C, Tsirigos A, Erlebacher A. PMID: 29202469; PMCID: PMC5749543.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    11. Inflammation and Autism: From Maternal Gut to Fetal Brain. Trends Mol Med. 2017 12; 23(12):1070-1071. Osokine I, Erlebacher A. PMID: 29122491.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    12. Baby's First Organ. Sci Am. 2017 Sep 19; 317(4):46-53. Erlebacher A, Fisher SJ. PMID: 29565852.
      View in: PubMed   Mentions: 4     Fields:    
    13. Limited Colonization Undermined by Inadequate Early Immune Responses Defines the Dynamics of Decidual Listeriosis. Infect Immun. 2017 08; 85(8). Rizzuto G, Tagliani E, Manandhar P, Erlebacher A, Bakardjiev AI. PMID: 28507070; PMCID: PMC5520438.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    14. Presence and Functionality of Resident Memory CD8 T Cells in the Pregnant Mouse Uterus. Journal of Reproductive Immunology. 2016 Jun 1; 115:37. Uiterweer UE, Siewiera SJ, Nancy NP, Erlebacher EA. .
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    15. Epigenetic regulation of decidual inflammation. Journal of Reproductive Immunology. 2016 Jun 1; 115:49. Erlebacher EA, Siewiera SJ, Nancy NP. .
      View in: Publisher Site   Mentions:
    16. Presence and functionality of resident memory CD8 T cells in the pregnant mouse uterus. Journal of Reproductive Immunology. 2016 Jun 1; 115:86. Uiterweer UE, Siewiera SJ, Nancy NP, Erlebacher EA. .
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    17. Neutrophils Oppose Uterine Epithelial Carcinogenesis via Debridement of Hypoxic Tumor Cells. Cancer Cell. 2015 Dec 14; 28(6):785-799. Blaisdell A, Crequer A, Columbus D, Daikoku T, Mittal K, Dey SK, Erlebacher A. PMID: 26678340; PMCID: PMC4698345.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    18. Immune mechanisms at the maternal-fetal interface: perspectives and challenges. Nat Immunol. 2015 Apr; 16(4):328-34. PrabhuDas M, Bonney E, Caron K, Dey S, Erlebacher A, Fazleabas A, Fisher S, Golos T, Matzuk M, McCune JM, Mor G, Schulz L, Soares M, Spencer T, Strominger J, Way SS, Yoshinaga K. PMID: 25789673; PMCID: PMC5070970.
      View in: PubMed   Mentions: 245     Fields:    Translation:HumansAnimals
    19. Neutrophil recruitment into premalignant lesions differentially influences tumor growth versus progression. (TUM4P.928). The Journal of Immunology. 2014 May 1; 192(1_Supplement):138.29-138.29. Blaisdell BA, Daikoku DT, Tay TC, Dey DS, Erlebacher EA. .
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    20. 19 Leukocyte Population Dynamics and Functions at the Maternal–Fetal Interface. The Guide to Investigation of Mouse Pregnancy. 2014 Jan 1; 227-242. Erlebacher EA. .
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    21. 53 Flow Cytometric Analysis of Myometrial and Decidual Cell Suspensions. The Guide to Investigation of Mouse Pregnancy. 2014 Jan 1; 619-628. Blaisdell BA, Erlebacher EA. .
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    22. 49 Immunofluorescence and Immunohistochemistry. The Guide to Investigation of Mouse Pregnancy. 2014 Jan 1; 577-589. Blaisdell BA, Erlebacher EA. .
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    23. T cell behavior at the maternal-fetal interface. Int J Dev Biol. 2014; 58(2-4):189-98. Nancy P, Erlebacher A. PMID: 25023685; PMCID: PMC4212519.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    24. Cis-acting pathways selectively enforce the non-immunogenicity of shed placental antigen for maternal CD8 T cells. PLoS One. 2013; 8(12):e84064. Tay CS, Tagliani E, Collins MK, Erlebacher A. PMID: 24391885; PMCID: PMC3877187.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    25. Immunology of the maternal-fetal interface. Annu Rev Immunol. 2013; 31:387-411. Erlebacher A. PMID: 23298207.
      View in: PubMed   Mentions: 374     Fields:    Translation:HumansAnimalsCells
    26. [Epigenetic repression of chemokine expression at the maternal-fetal interface as a mechanism of feto-maternal tolerance]. Med Sci (Paris). 2012 Dec; 28(12):1037-9. Nancy P, Erlebacher A. PMID: 23290395.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    27. Mechanisms of T cell tolerance towards the allogeneic fetus. Nat Rev Immunol. 2013 Jan; 13(1):23-33. Erlebacher A. PMID: 23237963.
      View in: PubMed   Mentions: 138     Fields:    Translation:HumansAnimalsCells
    28. Fetal programming and environmental exposures: implications for prenatal care and preterm birth. Ann N Y Acad Sci. 2012 Dec; 1276:37-46. Schug TT, Erlebacher A, Leibowitz S, Ma L, Muglia LJ, Rando OJ, Rogers JM, Romero R, vom Saal FS, Wise DL. PMID: 23278645; PMCID: PMC4154493.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    29. Chemokine gene silencing in decidual stromal cells limits T cell access to the maternal-fetal interface. Science. 2012 Jun 08; 336(6086):1317-21. Nancy P, Tagliani E, Tay CS, Asp P, Levy DE, Erlebacher A. PMID: 22679098; PMCID: PMC3727649.
      View in: PubMed   Mentions: 188     Fields:    Translation:AnimalsCells
    30. Dendritic cell function at the maternal-fetal interface. Expert Rev Clin Immunol. 2011 Sep; 7(5):593-602. Tagliani E, Erlebacher A. PMID: 21895472; PMCID: PMC3216484.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    31. Coordinate regulation of tissue macrophage and dendritic cell population dynamics by CSF-1. J Exp Med. 2011 Aug 29; 208(9):1901-16. Tagliani E, Shi C, Nancy P, Tay CS, Pamer EG, Erlebacher A. PMID: 21825019; PMCID: PMC3171096.
      View in: PubMed   Mentions: 90     Fields:    Translation:AnimalsCells
    32. miR-30b/30d regulation of GalNAc transferases enhances invasion and immunosuppression during metastasis. Cancer Cell. 2011 Jul 12; 20(1):104-18. Gaziel-Sovran A, Segura MF, Di Micco R, Collins MK, Hanniford D, Vega-Saenz de Miera E, Rakus JF, Dankert JF, Shang S, Kerbel RS, Bhardwaj N, Shao Y, Darvishian F, Zavadil J, Erlebacher A, Mahal LK, Osman I, Hernando E. PMID: 21741600; PMCID: PMC3681522.
      View in: PubMed   Mentions: 182     Fields:    Translation:HumansAnimalsCells
    33. Strangers no more: uterine NK cell recognition of the placenta in mice. Proc Natl Acad Sci U S A. 2011 Mar 15; 108(11):4267-8. Erlebacher A. PMID: 21372266; PMCID: PMC3060254.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    34. Acquisition and presentation of follicular dendritic cell-bound antigen by lymph node-resident dendritic cells. J Exp Med. 2011 Jan 17; 208(1):135-48. McCloskey ML, Curotto de Lafaille MA, Carroll MC, Erlebacher A. PMID: 21173103; PMCID: PMC3023135.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    35. Regulation of CD8 T cell responses by follicular dendritic cell-bound antigen (98.17). The Journal of Immunology. 2010 Apr 1; 184(1_Supplement):98.17-98.17. Erlebacher EA, Curotto de Lafaille CM, Lafaille LJ, Carroll CM, McCloskey MM. .
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    36. Immune surveillance of the maternal/fetal interface: controversies and implications. Trends Endocrinol Metab. 2010 Jul; 21(7):428-34. Erlebacher A. PMID: 20304670; PMCID: PMC2892024.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    37. Dendritic cell entrapment within the pregnant uterus inhibits immune surveillance of the maternal/fetal interface in mice. J Clin Invest. 2009 Jul; 119(7):2062-73. Collins MK, Tay CS, Erlebacher A. PMID: 19546507; PMCID: PMC2701881.
      View in: PubMed   Mentions: 117     Fields:    Translation:AnimalsCells
    38. Constraints in antigen presentation severely restrict T cell recognition of the allogeneic fetus. J Clin Invest. 2007 May; 117(5):1399-411. Erlebacher A, Vencato D, Price KA, Zhang D, Glimcher LH. PMID: 17446933; PMCID: PMC1849983.
      View in: PubMed   Mentions: 116     Fields:    Translation:AnimalsCells
    39. Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation. Journal of Clinical Investigation. 2006 Oct 2; 116(10):2643-2652. Red-Horse RK, Rivera RJ, Schanz SA, Zhou ZY, Winn WV, Kapidzic KM, Maltepe ME, Okazaki OK, Kochman KR, Vo VK, Giudice GL, Erlebacher EA, McCune MJ, Stoddart SC, Fisher FS. .
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    40. Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation. J Clin Invest. 2006 Oct; 116(10):2643-52. Red-Horse K, Rivera J, Schanz A, Zhou Y, Winn V, Kapidzic M, Maltepe E, Okazaki K, Kochman R, Vo KC, Giudice L, Erlebacher A, McCune JM, Stoddart CA, Fisher SJ. PMID: 16998586; PMCID: PMC1570373.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    41. Differential transcription of Eomes and T-bet during maturation of mouse uterine natural killer cells. J Leukoc Biol. 2005 Dec; 78(6):1347-55. Tayade C, Fang Y, Black GP, V A P, Erlebacher A, Croy BA. PMID: 16204645.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    42. National Institute on Drug Abuse Conference report on placental proteins, drug transport, and fetal development. Am J Obstet Gynecol. 2004 Dec; 191(6):1858-62. Thadani PV, Strauss JF, Dey SK, Anderson VM, Audus KL, Coats KS, Cross JC, Erlebacher A, Ganapathy V, Linzer DI, Miller RK, Novak DA, Rapaka RS, Sadovsky Y, Salafia CM, Soares M, Unadkat J. PMID: 15592265.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    43. Maintenance of mouse trophoblast stem cell proliferation by TGF-beta/activin. Dev Biol. 2004 Nov 01; 275(1):158-69. Erlebacher A, Price KA, Glimcher LH. PMID: 15464579.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    44. Ovarian insufficiency and early pregnancy loss induced by activation of the innate immune system. J Clin Invest. 2004 Jul; 114(1):39-48. Erlebacher A, Zhang D, Parlow AF, Glimcher LH. PMID: 15232610; PMCID: PMC437968.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    45. Intrinsic susceptibility of mouse trophoblasts to natural killer cell-mediated attack in vivo. Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26):16940-5. Erlebacher A, Lukens AK, Glimcher LH. PMID: 12486249; PMCID: PMC139248.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    46. Inhibition of TGF-beta receptor signaling in osteoblasts leads to decreased bone remodeling and increased trabecular bone mass. Development. 1999 Oct; 126(19):4267-79. Filvaroff E, Erlebacher A, Ye J, Gitelman SE, Lotz J, Heillman M, Derynck R. PMID: 10477295.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    47. Osteoblastic responses to TGF-beta during bone remodeling. Mol Biol Cell. 1998 Jul; 9(7):1903-18. Erlebacher A, Filvaroff EH, Ye JQ, Derynck R. PMID: 9658179; PMCID: PMC25433.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    48. Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype. J Cell Biol. 1996 Jan; 132(1-2):195-210. Erlebacher A, Derynck R. PMID: 8567723; PMCID: PMC2120709.
      View in: PubMed   Mentions: 111     Fields:    Translation:AnimalsCells
    49. Toward a molecular understanding of skeletal development. Cell. 1995 Feb 10; 80(3):371-8. Erlebacher A, Filvaroff EH, Gitelman SE, Derynck R. PMID: 7859279.
      View in: PubMed   Mentions: 132     Fields:    Translation:HumansAnimals
    50. THE ROLE OF TGF-ß FAMILY MEMBERS IN MESENCHYMAL DIFFERENTIATION. Pediatric Research. 1993 May 1; 33(Suppl 5):s9-s10. Derynck DR, Filvaroff FE, Erlebacher EA, Gitelman GS. .
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