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Joseph "Mike" McCune, MD, PhD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address1001 Potrero Ave
San Francisco CA 94110
Phone628-206-8102
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    Collapse Biography 
    Collapse Education and Training
    Stanford University Medical College, Palo Alto, CAPost-Doc Fellow/Scholar1988Pathology
    University of California, San Francisco Clinical Fellowship 1986Infectious Disease
    University of California, San FranciscoResidency 1984Internal Medicine
    Cornell University Medical College, New York, NYM.D.1982Medicine
    The Rockefeller University, New York, NYPh.D.1981Cell Biology/Immunology
    Harvard College, Cambridge, MAA.B.1975Biochemistry

    Collapse Overview 
    Collapse Overview
    Joseph ("Mike") McCune is a professor of medicine at the University of California, San Francisco (UCSF). He received his AB degree from Harvard College in 1975, his PhD degree from Rockefeller University in 1981, and his MD degree from Cornell University Medical College in 1982. He completed his residency in internal medicine in 1984 and did fellowship training in infectious diseases at UCSF. He is board certified in internal medicine.

    The McCune lab has been involved for many years in the analysis of HIV pathogenesis, prevention, treatment, and cure. Dr. McCune started to treat patients with HIV disease as a resident in internal medicine at UCSF in 1982 and has been involved in the HIV/AIDS research field ever since. This work included postdoctoral studies at Stanford, exploring the fusogenic properties of the HIV envelope protein and developing the first humanized mouse model (the SCID-hu mouse) capable of multilineage human hematopoiesis and receptive to infection with primary isolates of HIV. He then co-founded the companies SyStemix (in 1988) and Progenesys (and 1991), serving as Scientific Director and leading research efforts to find better ways – including antiviral medications and hematopoietic stem cell-based gene therapy – to treat HIV disease. In 1995, Dr. McCune returned to academia, first as an investigator at the Gladstone Institute of Virology and Immunology and then (from 2006-2016) as the Chief of the Division of Experimental Medicine (which he founded) at UCSF. Concomitantly, he was the founding PI (and Senior Associate Dean) of the Clinical and Translational Sciences Institute at UCSF (from 2005-08). In recent years, he has helped to form multidisciplinary, collaborative research teams to find a cure for HIV disease. Throughout this time, he has actively mentored graduate students and postdoctoral fellows, many of whom have gone on to successful careers in academia or biotech/pharma.

    Dr. McCune’s studies have led to the publication of over 200 peer-reviewed articles, and he is the holder of 20 patents and inventions. He is a member of many scientific and professional societies, including the American Society for Clinical Investigation, the American Association of Physicians, and the Henry Kunkel Society. He has served on the editorial boards of Virology and the Journal of the Acquired Immune Deficiency Syndrome. He was awarded the Elizabeth Glaser Pediatric AIDS Foundation Scientist Award in 1996, the Burroughs Wellcome Fund Clinical Scientist Award in Translational Research in 2000, a MERIT Award from the NIH in 2001, the NIH Director’s Pioneer Award in 2004, and the Holly Smith Award for Exceptional Service to the School of Medicine in 2016. He was also selected to give the UCSF Academic Senate Faculty Research Lecture (on Translational Science) in 2013.

    Collapse Research 
    Collapse Research Activities and Funding
    Interferon-independent mechanisms of malaria restriction by helper T cells
    NIH R21AI114916Sep 1, 2015 - Aug 31, 2017
    Role: Principal Investigator
    The impact of TB co-infection on the reservoir of persistent HIV in vivo
    NIH/NIAID R21AI116295Aug 1, 2015 - Jul 31, 2017
    Role: Principal Investigator
    Timing of ART and homeostasis of the persistent HIV reservoir in the adult
    NIH/NIAID R01AI116368Feb 4, 2015 - Jan 31, 2020
    Role: Principal Investigator
    Novel flow cytometry-based assay for HIV-infected cells
    NIH R21AI110143Dec 1, 2013 - Nov 30, 2015
    Role: Principal Investigator
    Layering of the human immune system, viral infections, and childhood asthma
    NIH R01AI100082Aug 21, 2012 - Jul 31, 2017
    Role: Principal Investigator
    DARE: Delaney AIDS Research Enterprise to find a cure.
    NIH/NIAID U19AI096109Jul 8, 2011 - Jun 30, 2016
    Role: Principal Investigator
    Human immune system layering and the neonatal response to vaccines
    NIH R21AI094009Mar 1, 2011 - Feb 28, 2014
    Role: Principal Investigator
    The Impact of Tolerance in the Newborn on Lentiviral Infection
    NIH R01AI090677Jul 2, 2010 - Jun 30, 2015
    Role: Principal Investigator
    Bay Area Hepatitis C Cooperative Research Center
    NIH U19AI088790Jun 15, 2010 - May 31, 2015
    Role: Principal Investigator
    Interruption of maternal-fetal transmission of HIV
    NIH R01AI084109Sep 5, 2009 - Aug 31, 2014
    Role: Principal Investigator
    HIV Proteomic Center for Host-Viral Response Characterization
    NIH P01DA026134Sep 30, 2008 - May 31, 2012
    Role: Co-Investigator
    Clinical and Transtional Science Institute
    NIH KL2RR024130Sep 30, 2006 - Jun 30, 2016
    Role: Principal Investigator
    Clinical and Transtional Science Institute
    NIH TL1RR024129Sep 30, 2006 - Jun 30, 2016
    Role: Principal Investigator
    Clinical and Translational Science Institute
    NIH UL1RR024131Sep 30, 2006 - Jun 30, 2016
    Role: Principal Investigator
    Anti-Gag Antibodies and Enhancement of Lentiviral Disease Progression
    NIH R21AI068583Jul 1, 2006 - Jun 30, 2009
    Role: Principal Investigator
    NIH Director's Pioneer Award (RMI)
    NIH DP1OD000329Sep 30, 2004 - Jul 31, 2010
    Role: Principal Investigator
    Beckman Coulter BioMek 2000 Workstation and Accessories
    NIH S10RR016959Apr 1, 2002 - Mar 31, 2003
    Role: Principal Investigator
    MOFLO TM HIGH PERFORMANCE FLOW CYTOMETER
    NIH S10RR013768Apr 1, 2000 - Mar 31, 2002
    Role: Principal Investigator
    Assessing Laboratory Correlates of Immune Protection
    NIH R01AI047062Feb 1, 2000 - Dec 31, 2008
    Role: Principal Investigator
    HUMAN IMMUNE CELL MATURATION DURING ONTOGENY AND INFECTI
    NIH/NIAID P01AI045865Sep 30, 1999 - Aug 31, 2003
    Role: Co-Investigator
    Thymic Function in Adults With HIV-1 Disease
    NIH U01AI043864Mar 1, 1999 - Mar 31, 2010
    Role: Principal Investigator
    THYMIC FUNCTION IN ADULTS WITH HIV1 DISEASE
    NIH R01AI043864Mar 1, 1999 - Feb 28, 2003
    Role: Principal Investigator
    SCID-HU ANIMAL MODEL FOR EVALUATING HIV THERAPIES
    NIH N01AI065309Jul 1, 1996 - Sep 29, 2000
    Role: Principal Investigator
    HIV EFFECTS ON THE CENTRAL HEMATOLYMPHOID SYSTEM
    NIH R37AI040312Apr 1, 1996 - Feb 28, 2012
    Role: Principal Investigator
    HIV EFFECTS ON THE CENTRAL HEMATOLYMPHOID SYSTEM IN VIVO
    NIH R01AI040312Apr 1, 1996 - Jul 31, 2000
    Role: Principal Investigator
    DISCOVERY AND DEVELOPMENT OF THERAPEUTIC COMPOUNDS
    NIH R13CA060157Mar 18, 1993 - Mar 17, 1994
    Role: Principal Investigator
    HIV INFECTION IN THE SCID-HU MOUSE
    NIH R01AI029323Sep 30, 1989 - Jul 31, 1995
    Role: Principal Investigator
    California National Primate Research Center
    NIH P51RR000169Jun 1, 1975 - Apr 30, 2015
    Role: Co-Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000083Oct 1, 1974 - Sep 29, 2006
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Global Health
    Collapse Websites
    Collapse In The News
    Collapse Student Projects

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Immunotherapeutic Blockade of CD47 Inhibitory Signaling Enhances Innate and Adaptive Immune Responses to Viral Infection. Cell Rep. 2020 Apr 14; 31(2):107494. Cham LB, Torrez Dulgeroff LB, Tal MC, Adomati T, Li F, Bhat H, Huang A, Lang PA, Moreno ME, Rivera JM, Galkina SA, Kosikova G, Stoddart CA, McCune JM, Myers LM, Weissman IL, Lang KS, Hasenkrug KJ. PMID: 32294445.
      View in: PubMed   Mentions: 1     Fields:    
    2. Why and where an HIV cure is needed and how it might be achieved. Nature. 2019 12; 576(7787):397-405. Ndung'u T, McCune JM, Deeks SG. PMID: 31853080.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    3. The Ban on US Government Funding Research Using Human Fetal Tissues: How Does This Fit with the NIH Mission to Advance Medical Science for the Benefit of the Citizenry? Stem Cell Reports. 2019 11 12; 13(5):777-786. McCune JM, Weissman IL. PMID: 31722191.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    4. Some Aspects of CD8+ T-Cell Exhaustion Are Associated With Altered T-Cell Mitochondrial Features and ROS Content in HIV Infection. J Acquir Immune Defic Syndr. 2019 10 01; 82(2):211-219. Deguit CDT, Hough M, Hoh R, Krone M, Pilcher CD, Martin JN, Deeks SG, McCune JM, Hunt PW, Rutishauser RL. PMID: 31513075.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. 2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus. Arthritis Rheumatol. 2019 09; 71(9):1400-1412. Aringer M, Costenbader K, Daikh D, Brinks R, Mosca M, Ramsey-Goldman R, Smolen JS, Wofsy D, Boumpas DT, Kamen DL, Jayne D, Cervera R, Costedoat-Chalumeau N, Diamond B, Gladman DD, Hahn B, Hiepe F, Jacobsen S, Khanna D, Lerstrøm K, Massarotti E, McCune J, Ruiz-Irastorza G, Sanchez-Guerrero J, Schneider M, Urowitz M, Bertsias G, Hoyer BF, Leuchten N, Tani C, Tedeschi SK, Touma Z, Schmajuk G, Anic B, Assan F, Chan TM, Clarke AE, Crow MK, Czirják L, Doria A, Graninger W, Halda-Kiss B, Hasni S, Izmirly PM, Jung M, Kumánovics G, Mariette X, Padjen I, Pego-Reigosa JM, Romero-Diaz J, Rúa-Figueroa Fernández Í, Seror R, Stummvoll GH, Tanaka Y, Tektonidou MG, Vasconcelos C, Vital EM, Wallace DJ, Yavuz S, Meroni PL, Fritzler MJ, Naden R, Dörner T, Johnson SR. PMID: 31385462.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    6. 2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus. Ann Rheum Dis. 2019 09; 78(9):1151-1159. Aringer M, Costenbader K, Daikh D, Brinks R, Mosca M, Ramsey-Goldman R, Smolen JS, Wofsy D, Boumpas DT, Kamen DL, Jayne D, Cervera R, Costedoat-Chalumeau N, Diamond B, Gladman DD, Hahn B, Hiepe F, Jacobsen S, Khanna D, Lerstrøm K, Massarotti E, McCune J, Ruiz-Irastorza G, Sanchez-Guerrero J, Schneider M, Urowitz M, Bertsias G, Hoyer BF, Leuchten N, Tani C, Tedeschi SK, Touma Z, Schmajuk G, Anic B, Assan F, Chan TM, Clarke AE, Crow MK, Czirják L, Doria A, Graninger W, Halda-Kiss B, Hasni S, Izmirly PM, Jung M, Kumánovics G, Mariette X, Padjen I, Pego-Reigosa JM, Romero-Diaz J, Rúa-Figueroa Fernández Í, Seror R, Stummvoll GH, Tanaka Y, Tektonidou MG, Vasconcelos C, Vital EM, Wallace DJ, Yavuz S, Meroni PL, Fritzler MJ, Naden R, Dörner T, Johnson SR. PMID: 31383717.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    7. Kynurenine 3-Monooxygenase Inhibition during Acute Simian Immunodeficiency Virus Infection Lowers PD-1 Expression and Improves Post-Combination Antiretroviral Therapy CD4+ T Cell Counts and Body Weight. J Immunol. 2019 08 15; 203(4):899-910. Swainson LA, Ahn H, Pajanirassa P, Khetarpal V, Deleage C, Estes JD, Hunt PW, Munoz-Sanjuan I, McCune JM. PMID: 31285277.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    8. CD32-RNA Co-localizes with HIV-RNA in CD3+ Cells Found within Gut Tissues from Viremic and ART-Suppressed Individuals. Pathog Immun. 2019; 4(1):147-160. Vásquez JJ, Aguilar-Rodriguez BL, Rodriguez L, Hogan LE, Somsouk M, McCune JM, Deeks SG, Laszik ZG, Hunt PW, Henrich TJ. PMID: 31139759.
      View in: PubMed   Mentions:
    9. HIV "cure": A shot in the arm? EBioMedicine. 2019 04; 42:3-5. Peluso MJ, Deeks SG, McCune JM. PMID: 30982768.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    10. Genetic fine mapping of systemic lupus erythematosus MHC associations in Europeans and African Americans. Hum Mol Genet. 2018 11 01; 27(21):3813-3824. Hanscombe KB, Morris DL, Noble JA, Dilthey AT, Tombleson P, Kaufman KM, Comeau M, Langefeld CD, Alarcon-Riquelme ME, Gaffney PM, Jacob CO, Sivils KL, Tsao BP, Alarcon GS, Brown EE, Croker J, Edberg J, Gilkeson G, James JA, Kamen DL, Kelly JA, McCune J, Merrill JT, Petri M, Ramsey-Goldman R, Reveille JD, Salmon JE, Scofield H, Utset T, Wallace DJ, Weisman MH, Kimberly RP, Harley JB, Lewis CM, Criswell LA, Vyse TJ. PMID: 30085094.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. A20 upregulation during treated HIV disease is associated with intestinal epithelial cell recovery and function. PLoS Pathog. 2018 03; 14(3):e1006806. Chitre AS, Kattah MG, Rosli YY, Pao M, Deswal M, Deeks SG, Hunt PW, Abdel-Mohsen M, Montaner LJ, Kim CC, Ma A, Somsouk M, McCune JM. PMID: 29505600.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    12. Elucidating the Burden of HIV in Tissues Using Multiplexed Immunofluorescence and In Situ Hybridization: Methods for the Single-Cell Phenotypic Characterization of Cells Harboring HIV In Situ. J Histochem Cytochem. 2018 06; 66(6):427-446. Vasquez JJ, Hussien R, Aguilar-Rodriguez B, Junger H, Dobi D, Henrich TJ, Thanh C, Gibson E, Hogan LE, McCune J, Hunt PW, Stoddart CA, Laszik ZG. PMID: 29462571.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    13. Glut1 Expression Level on Inflammatory Monocytes is Associated With Markers of Cardiovascular Disease Risk in HIV-Infected Individuals. J Acquir Immune Defic Syndr. 2018 02 01; 77(2):e28-e30. Anzinger JJ, Butterfield TR, Gouillou M, McCune JM, Crowe SM, Palmer CS. PMID: 28961681.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    14. Memory T Cell Proliferation before Hepatitis C Virus Therapy Predicts Antiviral Immune Responses and Treatment Success. J Immunol. 2018 02 01; 200(3):1124-1132. Méndez-Lagares G, Lu D, Chen C, Terrault N, Segal MR, Khalili M, Monto A, Shen H, Manos MM, Lanier LL, Ryan JC, McCune JM, Hartigan-O'Connor DJ. PMID: 29263212.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    15. HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study. PLoS Med. 2017 Nov; 14(11):e1002417. Henrich TJ, Hatano H, Bacon O, Hogan LE, Rutishauser R, Hill A, Kearney MF, Anderson EM, Buchbinder SP, Cohen SE, Abdel-Mohsen M, Pohlmeyer CW, Fromentin R, Hoh R, Liu AY, McCune JM, Spindler J, Metcalf-Pate K, Hobbs KS, Thanh C, Gibson EA, Kuritzkes DR, Siliciano RF, Price RW, Richman DD, Chomont N, Siliciano JD, Mellors JW, Yukl SA, Blankson JN, Liegler T, Deeks SG. PMID: 29112956.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCellsPHPublic Health
    16. IL-21 Therapy Controls Immune Activation and Maintains Antiviral CD8+ T Cell Responses in Acute Simian Immunodeficiency Virus Infection. AIDS Res Hum Retroviruses. 2017 Nov; 33(S1):S81-S92. Méndez-Lagares G, Lu D, Merriam D, Baker CA, Villinger F, Van Rompay KKA, McCune JM, Hartigan-O'Connor DJ. PMID: 29140110.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    17. Metabolically active CD4+ T cells expressing Glut1 and OX40 preferentially harbor HIV during in vitro infection. FEBS Lett. 2017 10; 591(20):3319-3332. Palmer CS, Duette GA, Wagner MCE, Henstridge DC, Saleh S, Pereira C, Zhou J, Simar D, Lewin SR, Ostrowski M, McCune JM, Crowe SM. PMID: 28892135.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    18. Defining total-body AIDS-virus burden with implications for curative strategies. Nat Med. 2017 Nov; 23(11):1271-1276. Estes JD, Kityo C, Ssali F, Swainson L, Makamdop KN, Del Prete GQ, Deeks SG, Luciw PA, Chipman JG, Beilman GJ, Hoskuldsson T, Khoruts A, Anderson J, Deleage C, Jasurda J, Schmidt TE, Hafertepe M, Callisto SP, Pearson H, Reimann T, Schuster J, Schoephoerster J, Southern P, Perkey K, Shang L, Wietgrefe SW, Fletcher CV, Lifson JD, Douek DC, McCune JM, Haase AT, Schacker TW. PMID: 28967921.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    19. Mass Cytometric Analysis of HIV Entry, Replication, and Remodeling in Tissue CD4+ T Cells. Cell Rep. 2017 07 25; 20(4):984-998. Cavrois M, Banerjee T, Mukherjee G, Raman N, Hussien R, Rodriguez BA, Vasquez J, Spitzer MH, Lazarus NH, Jones JJ, Ochsenbauer C, McCune JM, Butcher EC, Arvin AM, Sen N, Greene WC, Roan NR. PMID: 28746881.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    20. Transancestral mapping and genetic load in systemic lupus erythematosus. Nat Commun. 2017 07 17; 8:16021. Langefeld CD, Ainsworth HC, Cunninghame Graham DS, Kelly JA, Comeau ME, Marion MC, Howard TD, Ramos PS, Croker JA, Morris DL, Sandling JK, Almlöf JC, Acevedo-Vásquez EM, Alarcón GS, Babini AM, Baca V, Bengtsson AA, Berbotto GA, Bijl M, Brown EE, Brunner HI, Cardiel MH, Catoggio L, Cervera R, Cucho-Venegas JM, Dahlqvist SR, D'Alfonso S, Da Silva BM, de la Rúa Figueroa I, Doria A, Edberg JC, Endreffy E, Esquivel-Valerio JA, Fortin PR, Freedman BI, Frostegård J, García MA, de la Torre IG, Gilkeson GS, Gladman DD, Gunnarsson I, Guthridge JM, Huggins JL, James JA, Kallenberg CGM, Kamen DL, Karp DR, Kaufman KM, Kottyan LC, Kovács L, Laustrup H, Lauwerys BR, Li QZ, Maradiaga-Ceceña MA, Martín J, McCune JM, McWilliams DR, Merrill JT, Miranda P, Moctezuma JF, Nath SK, Niewold TB, Orozco L, Ortego-Centeno N, Petri M, Pineau CA, Pons-Estel BA, Pope J, Raj P, Ramsey-Goldman R, Reveille JD, Russell LP, Sabio JM, Aguilar-Salinas CA, Scherbarth HR, Scorza R, Seldin MF, Sjöwall C, Svenungsson E, Thompson SD, Toloza SMA, Truedsson L, Tusié-Luna T, Vasconcelos C, Vilá LM, Wallace DJ, Weisman MH, Wither JE, Bhangale T, Oksenberg JR, Rioux JD, Gregersen PK, Syvänen AC, Rönnblom L, Criswell LA, Jacob CO, Sivils KL, Tsao BP, Schanberg LE, Behrens TW, Silverman ED, Alarcón-Riquelme ME, Kimberly RP, Harley JB, Wakeland EK, Graham RR, Gaffney PM, Vyse TJ. PMID: 28714469.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    21. Limited engraftment of donor microbiome via one-time fecal microbial transplantation in treated HIV-infected individuals. Gut Microbes. 2017 09 03; 8(5):440-450. Vujkovic-Cvijin I, Rutishauser RL, Pao M, Hunt PW, Lynch SV, McCune JM, Somsouk M. PMID: 28541799.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    22. Early and Delayed Antiretroviral Therapy Results in Comparable Reductions in CD8+ T Cell Exhaustion Marker Expression. AIDS Res Hum Retroviruses. 2017 07; 33(7):658-667. Rutishauser RL, Hartogensis W, Deguit CD, Krone M, Hoh R, Hecht FM, Pilcher CD, Bacchetti P, Deeks SG, Hunt PW, McCune JM. PMID: 28335609.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCellsPHPublic Health
    23. Relative mRNA Expression Levels of Restriction Factors and Antiviral Genes in Fetal and Adult Human Monocytes and Monocyte-Derived Macrophages. Viral Immunol. 2017 04; 30(3):142-148. Trang K, Raposo RA, Lowe MM, Krow-Lucal ER, Yonemoto W, Cabido VD, SenGupta D, McCune JM. PMID: 28151065.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    24. Lin28b Regulates Fetal Regulatory T Cell Differentiation through Modulation of TGF-ß Signaling. J Immunol. 2016 12 01; 197(11):4344-4350. Bronevetsky Y, Burt TD, McCune JM. PMID: 27793996.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    25. MR Diffusion Tractography to Identify and Characterize Microstructural White Matter Tract Changes in Systemic Lupus Erythematosus Patients. Acad Radiol. 2016 11; 23(11):1431-1440. Shastri R, Shah G, Wang P, Cagnoli P, Schmidt-Wilcke T, McCune J, Harris R, Sundgren P. PMID: 27746120.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    26. Henry Kunkel and the teaching of patient-oriented research. Clin Immunol. 2016 11; 172:27-28. McCune JM. PMID: 27538773.
      View in: PubMed   Mentions:    Fields:    
    27. A Simple Flow Cytometric Method to Measure Glucose Uptake and Glucose Transporter Expression for Monocyte Subpopulations in Whole Blood. J Vis Exp. 2016 08 12; (114). Palmer CS, Anzinger JJ, Butterfield TR, McCune JM, Crowe SM. PMID: 27584036.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    28. International AIDS Society global scientific strategy: towards an HIV cure 2016. Nat Med. 2016 08; 22(8):839-50. Deeks SG, Lewin SR, Ross AL, Ananworanich J, Benkirane M, Cannon P, Chomont N, Douek D, Lifson JD, Lo YR, Kuritzkes D, Margolis D, Mellors J, Persaud D, Tucker JD, Barre-Sinoussi F, Alter G, Auerbach J, Autran B, Barouch DH, Behrens G, Cavazzana M, Chen Z, Cohen ÉA, Corbelli GM, Eholié S, Eyal N, Fidler S, Garcia L, Grossman C, Henderson G, Henrich TJ, Jefferys R, Kiem HP, McCune J, Moodley K, Newman PA, Nijhuis M, Nsubuga MS, Ott M, Palmer S, Richman D, Saez-Cirion A, Sharp M, Siliciano J, Silvestri G, Singh J, Spire B, Taylor J, Tolstrup M, Valente S, van Lunzen J, Walensky R, Wilson I, Zack J. PMID: 27400264.
      View in: PubMed   Mentions: 119     Fields:    Translation:Humans
    29. Impact of early cART in the gut during acute HIV infection. JCI Insight. 2016 Jul 07; 1(10). Deleage C, Schuetz A, Alvord WG, Johnston L, Hao XP, Morcock DR, Rerknimitr R, Fletcher JL, Puttamaswin S, Phanuphak N, Dewar R, McCune JM, Sereti I, Robb M, Kim JH, Schacker TW, Hunt P, Lifson JD, Ananworanich J, Estes JD. PMID: 27446990.
      View in: PubMed   Mentions: 17     Fields:    
    30. Colony-Stimulating Factor 1 Receptor Antagonists Sensitize Human Immunodeficiency Virus Type 1-Infected Macrophages to TRAIL-Mediated Killing. J Virol. 2016 07 15; 90(14):6255-6262. Cunyat F, Rainho JN, West B, Swainson L, McCune JM, Stevenson M. PMID: 27122585.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    31. IL-15 promotes activation and expansion of CD8+ T cells in HIV-1 infection. J Clin Invest. 2016 07 01; 126(7):2745-56. Younes SA, Freeman ML, Mudd JC, Shive CL, Reynaldi A, Panigrahi S, Estes JD, Deleage C, Lucero C, Anderson J, Schacker TW, Davenport MP, McCune JM, Hunt PW, Lee SA, Serrano-Villar S, Debernardo RL, Jacobson JM, Canaday DH, Sekaly RP, Rodriguez B, Sieg SF, Lederman MM. PMID: 27322062.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    32. Immunologic profiles distinguish aviremic HIV-infected adults. AIDS. 2016 06 19; 30(10):1553-62. Ramirez CM, Sinclair E, Epling L, Lee SA, Jain V, Hsue PY, Hatano H, Conn D, Hecht FM, Martin JN, McCune JM, Deeks SG, Hunt PW. PMID: 26854811.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    33. Eye examination for early diagnosis of disseminated tuberculosis in patients with AIDS. Lancet Infect Dis. 2016 Apr; 16(4):493-9. Heiden D, Saranchuk P, Keenan JD, Ford N, Lowinger A, Yen M, McCune J, Rao NA. PMID: 26907735.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    34. Defining HIV and SIV Reservoirs in Lymphoid Tissues. Pathog Immun. 2016; 1(1):68-106. Deleage C, Wietgrefe SW, Del Prete G, Morcock DR, Hao XP, Piatak M, Bess J, Anderson JL, Perkey KE, Reilly C, McCune JM, Haase AT, Lifson JD, Schacker TW, Estes JD. PMID: 27430032.
      View in: PubMed   Mentions:
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    169. Coinfection of SCID-hu Thy/Liv mice with human herpesvirus 6 and human immunodeficiency virus type 1. J Virol. 2000 Sep; 74(18):8726-31. Gobbi A, Stoddart CA, Locatelli G, Santoro F, Bare C, Linquist-Stepps V, Moreno ME, Abbey NW, Herndier BG, Malnati MS, McCune JM, Lusso P. PMID: 10954574.
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    170. Causal relationships between HIV-1 coreceptor utilization, tropism, and pathogenesis in human thymus. AIDS Res Hum Retroviruses. 2000 Jul 20; 16(11):1039-45. Berkowitz RD, Alexander S, McCune JM. PMID: 10933618.
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    171. Successful allogeneic bone marrow transplant in an HIV-1-positive man with chronic myelogenous leukemia. J Acquir Immune Defic Syndr. 2000 Jul 01; 24(3):289-90. Schlegel P, Beatty P, Halvorsen R, McCune J. PMID: 10969356.
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    172. A membrane-bound Fas decoy receptor expressed by human thymocytes. J Biol Chem. 2000 Mar 17; 275(11):7988-93. Jenkins M, Keir M, McCune JM. PMID: 10713117.
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    173. Antiviral activity of 2'-deoxy-3'-oxa-4'-thiocytidine (BCH-10652) against lamivudine-resistant human immunodeficiency virus type 1 in SCID-hu Thy/Liv mice. Antimicrob Agents Chemother. 2000 Mar; 44(3):783-6. Stoddart CA, Moreno ME, Linquist-Stepps VD, Bare C, Bogan MR, Gobbi A, Buckheit RW, Bedard J, Rando RF, McCune JM. PMID: 10681360.
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    174. Factors influencing T-cell turnover in HIV-1-seropositive patients. J Clin Invest. 2000 Mar; 105(5):R1-8. McCune JM, Hanley MB, Cesar D, Halvorsen R, Hoh R, Schmidt D, Wieder E, Deeks S, Siler S, Neese R, Hellerstein M. PMID: 10712441.
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    175. Reversal of human immunodeficiency virus type 1-associated hematosuppression by effective antiretroviral therapy. Clin Infect Dis. 2000 Mar; 30(3):504-10. Huang SS, Barbour JD, Deeks SG, Huang JS, Grant RM, Ng VL, McCune JM. PMID: 10722435.
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    176. Thymic size and lymphocyte restoration in patients with human immunodeficiency virus infection after 48 weeks of zidovudine, lamivudine, and ritonavir therapy. J Infect Dis. 2000 Jan; 181(1):141-7. Smith KY, Valdez H, Landay A, Spritzler J, Kessler HA, Connick E, Kuritzkes D, Gross B, Francis I, McCune JM, Lederman MM. PMID: 10608760.
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    177. Experimental transmission of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) to SCID-hu Thy/Liv mice. J Exp Med. 1999 Dec 20; 190(12):1857-68. Dittmer D, Stoddart C, Renne R, Linquist-Stepps V, Moreno ME, Bare C, McCune JM, Ganem D. PMID: 10601360.
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    178. R5 strains of human immunodeficiency virus type 1 from rapid progressors lacking X4 strains do not possess X4-type pathogenicity in human thymus. J Virol. 1999 Sep; 73(9):7817-22. Berkowitz RD, van't Wout AB, Kootstra NA, Moreno ME, Linquist-Stepps VD, Bare C, Stoddart CA, Schuitemaker H, McCune JM. PMID: 10438873.
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    179. Direct evidence for thymic function in adult humans. J Exp Med. 1999 Aug 16; 190(4):479-86. Poulin JF, Viswanathan MN, Harris JM, Komanduri KV, Wieder E, Ringuette N, Jenkins M, McCune JM, Sékaly RP. PMID: 10449519.
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    180. Fas is expressed early in human thymocyte development but does not transmit an apoptotic signal. J Immunol. 1999 Aug 01; 163(3):1195-204. Jenkins M, Keir M, McCune JM. PMID: 10415014.
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    181. Human herpesvirus 6 (HHV-6) causes severe thymocyte depletion in SCID-hu Thy/Liv mice. J Exp Med. 1999 Jun 21; 189(12):1953-60. Gobbi A, Stoddart CA, Malnati MS, Locatelli G, Santoro F, Abbey NW, Bare C, Linquist-Stepps V, Moreno MB, Herndier BG, Lusso P, McCune JM. PMID: 10377191.
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    182. Induction of MHC class I expression on immature thymocytes in HIV-1-infected SCID-hu Thy/Liv mice: evidence of indirect mechanisms. J Immunol. 1999 Jun 15; 162(12):7555-62. Kovalev G, Duus K, Wang L, Lee R, Bonyhadi M, Ho D, McCune JM, Kaneshima H, Su L. PMID: 10358212.
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    183. Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans. Nat Med. 1999 Jan; 5(1):83-9. Hellerstein M, Hanley MB, Cesar D, Siler S, Papageorgopoulos C, Wieder E, Schmidt D, Hoh R, Neese R, Macallan D, Deeks S, McCune JM. PMID: 9883844.
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    184. CCR5- and CXCR4-utilizing strains of human immunodeficiency virus type 1 exhibit differential tropism and pathogenesis in vivo. J Virol. 1998 Dec; 72(12):10108-17. Berkowitz RD, Alexander S, Bare C, Linquist-Stepps V, Bogan M, Moreno ME, Gibson L, Wieder ED, Kosek J, Stoddart CA, McCune JM. PMID: 9811751.
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    185. CXCR4 and CCR5 expression delineates targets for HIV-1 disruption of T cell differentiation. J Immunol. 1998 Oct 01; 161(7):3702-10. Berkowitz RD, Beckerman KP, Schall TJ, McCune JM. PMID: 9759895.
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    186. Inhibition of human immunodeficiency virus type 1 infection in SCID-hu Thy/Liv mice by the G-quartet-forming oligonucleotide, ISIS 5320. Antimicrob Agents Chemother. 1998 Aug; 42(8):2113-5. Stoddart CA, Rabin L, Hincenbergs M, Moreno M, Linquist-Stepps V, Leeds JM, Truong LA, Wyatt JR, Ecker DJ, McCune JM. PMID: 9687417.
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    187. Restoration of cytomegalovirus-specific CD4+ T-lymphocyte responses after ganciclovir and highly active antiretroviral therapy in individuals infected with HIV-1. Nat Med. 1998 Aug; 4(8):953-6. Komanduri KV, Viswanathan MN, Wieder ED, Schmidt DK, Bredt BM, Jacobson MA, McCune JM. PMID: 9701250.
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    188. High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection. J Clin Invest. 1998 Jun 01; 101(11):2301-8. McCune JM, Loftus R, Schmidt DK, Carroll P, Webster D, Swor-Yim LB, Francis IR, Gross BH, Grant RM. PMID: 9616201.
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    189. Human immunodeficiency virus-1 infection interrupts thymopoiesis and multilineage hematopoiesis in vivo. Blood. 1998 Apr 15; 91(8):2672-8. Jenkins M, Hanley MB, Moreno MB, Wieder E, McCune JM. PMID: 9531575.
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    190. Furry flasks? Nat Biotechnol. 1998 Apr; 16(4):314. Namikawa R, Kaneshima H, McCune JM. PMID: 9555715.
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    191. UV irradiation of polystyrene pipets releases PCR inhibitors. Biotechniques. 1998 Jan; 24(1):50-2. Linquist V, Stoddart CA, McCune JM. PMID: 9454951.
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    196. Identification of HIV-1 determinants for replication in vivo. Virology. 1997 Jan 06; 227(1):45-52. Su L, Kaneshima H, Bonyhadi ML, Lee R, Auten J, Wolf A, Du B, Rabin L, Hahn BH, Terwilliger E, Mccune JM. PMID: 9007057.
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    198. Measles virus infection of thymic epithelium in the SCID-hu mouse leads to thymocyte apoptosis. J Virol. 1996 Jun; 70(6):3734-40. Auwaerter PG, Kaneshima H, McCune JM, Wiegand G, Griffin DE. PMID: 8648708.
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    199. Antiviral efficacy in vivo of the anti-human immunodeficiency virus bicyclam SDZ SID 791 (JM 3100), an inhibitor of infectious cell entry. Antimicrob Agents Chemother. 1996 Mar; 40(3):750-4. Datema R, Rabin L, Hincenbergs M, Moreno MB, Warren S, Linquist V, Rosenwirth B, Seifert J, McCune JM. PMID: 8851605.
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    200. Use of standardized SCID-hu Thy/Liv mouse model for preclinical efficacy testing of anti-human immunodeficiency virus type 1 compounds. Antimicrob Agents Chemother. 1996 Mar; 40(3):755-62. Rabin L, Hincenbergs M, Moreno MB, Warren S, Linquist V, Datema R, Charpiot B, Seifert J, Kaneshima H, McCune JM. PMID: 8851606.
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    201. HIV and the cells it infects: sorting the latent from the labile. An interview with Mike McCune, MD, PhD. Interview by Mark Mascolini. J Int Assoc Physicians AIDS Care. 1996 Jan; 2(1):20-2, 25-7, 41. McCune JM. PMID: 11363326.
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    202. Development of a human thymic organ culture model for the study of HIV pathogenesis. AIDS Res Hum Retroviruses. 1995 Sep; 11(9):1073-80. Bonyhadi ML, Su L, Auten J, McCune JM, Kaneshima H. PMID: 8554904.
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    203. Viral latency in HIV disease. Cell. 1995 Jul 28; 82(2):183-8. McCune JM. PMID: 7628009.
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    205. Rapid-high, syncytium-inducing isolates of human immunodeficiency virus type 1 induce cytopathicity in the human thymus of the SCID-hu mouse. J Virol. 1994 Dec; 68(12):8188-92. Kaneshima H, Su L, Bonyhadi ML, Connor RI, Ho DD, McCune JM. PMID: 7966610.
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    207. Direct evaluation of radiation damage in human hematopoietic progenitor cells in vivo. Radiat Res. 1994 Jan; 137(1):76-83. Kyoizumi S, McCune JM, Namikawa R. PMID: 7505456.
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    208. Human neural xenografts: progress in developing an in-vivo model to study human immunodeficiency virus (HIV) and human cytomegalovirus (HCMV) infection. Adv Neuroimmunol. 1994; 4(3):257-60. Epstein LG, Cvetkovich TA, Lazar ES, DiLoreto D, Saito Y, James H, del Cerro C, Kaneshima H, McCune JM, Britt WJ. PMID: 7874392.
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    210. HIV induces thymus depletion in vivo. Nature. 1993 Jun 24; 363(6431):728-32. Bonyhadi ML, Rabin L, Salimi S, Brown DA, Kosek J, McCune JM, Kaneshima H. PMID: 8100043.
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