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Joseph "Mike" McCune, MD, PhD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Phone415-206-8101
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    Collapse Biography 
    Collapse Education and Training
    Stanford University Medical College, Palo Alto, CAPost-Doc Fellow/Scholar1988Pathology
    University of California, San Francisco Clinical Fellowship 1986Infectious Disease
    University of California, San FranciscoResidency 1984Internal Medicine
    Cornell University Medical College, New York, NYM.D.1982Medicine
    The Rockefeller University, New York, NYPh.D.1981Cell Biology/Immunology
    Harvard College, Cambridge, MAA.B.1975Biochemistry

    Collapse Overview 
    Collapse Overview
    Joseph ("Mike") McCune is a professor of medicine at the University of California, San Francisco (UCSF). He received his AB degree from Harvard College in 1975, his PhD degree from Rockefeller University in 1981, and his MD degree from Cornell University Medical College in 1982. He completed his residency in internal medicine in 1984 and did fellowship training in infectious diseases at UCSF. He is board certified in internal medicine.

    The McCune lab has been involved for many years in the analysis of HIV pathogenesis, prevention, treatment, and cure. Dr. McCune started to treat patients with HIV disease as a resident in internal medicine at UCSF in 1982 and has been involved in the HIV/AIDS research field ever since. This work included postdoctoral studies at Stanford, exploring the fusogenic properties of the HIV envelope protein and developing the first humanized mouse model (the SCID-hu mouse) capable of multilineage human hematopoiesis and receptive to infection with primary isolates of HIV. He then co-founded the companies SyStemix (in 1988) and Progenesys (and 1991), serving as Scientific Director and leading research efforts to find better ways – including antiviral medications and hematopoietic stem cell-based gene therapy – to treat HIV disease. In 1995, Dr. McCune returned to academia, first as an investigator at the Gladstone Institute of Virology and Immunology and then (from 2006-2016) as the Chief of the Division of Experimental Medicine (which he founded) at UCSF. Concomitantly, he was the founding PI (and Senior Associate Dean) of the Clinical and Translational Sciences Institute at UCSF (from 2005-08). In recent years, he has helped to form multidisciplinary, collaborative research teams to find a cure for HIV disease. Throughout this time, he has actively mentored graduate students and postdoctoral fellows, many of whom have gone on to successful careers in academia or biotech/pharma.

    Dr. McCune’s studies have led to the publication of over 200 peer-reviewed articles, and he is the holder of 20 patents and inventions. He is a member of many scientific and professional societies, including the American Society for Clinical Investigation, the American Association of Physicians, and the Henry Kunkel Society. He has served on the editorial boards of Virology and the Journal of the Acquired Immune Deficiency Syndrome. He was awarded the Elizabeth Glaser Pediatric AIDS Foundation Scientist Award in 1996, the Burroughs Wellcome Fund Clinical Scientist Award in Translational Research in 2000, a MERIT Award from the NIH in 2001, the NIH Director’s Pioneer Award in 2004, and the Holly Smith Award for Exceptional Service to the School of Medicine in 2016. He was also selected to give the UCSF Academic Senate Faculty Research Lecture (on Translational Science) in 2013.

    Collapse Research 
    Collapse Research Activities and Funding
    Interferon-independent mechanisms of malaria restriction by helper T cells
    NIH R21AI114916Sep 1, 2015 - Aug 31, 2017
    Role: Principal Investigator
    The impact of TB co-infection on the reservoir of persistent HIV in vivo
    NIH/NIAID R21AI116295Aug 1, 2015 - Jul 31, 2017
    Role: Principal Investigator
    Timing of ART and homeostasis of the persistent HIV reservoir in the adult
    NIH/NIAID R01AI116368Feb 4, 2015 - Jan 31, 2020
    Role: Principal Investigator
    Novel flow cytometry-based assay for HIV-infected cells
    NIH R21AI110143Dec 1, 2013 - Nov 30, 2015
    Role: Principal Investigator
    Layering of the human immune system, viral infections, and childhood asthma
    NIH R01AI100082Aug 21, 2012 - Jul 31, 2017
    Role: Principal Investigator
    DARE: Delaney AIDS Research Enterprise to find a cure.
    NIH/NIAID U19AI096109Jul 8, 2011 - Jun 30, 2016
    Role: Principal Investigator
    Human immune system layering and the neonatal response to vaccines
    NIH R21AI094009Mar 1, 2011 - Feb 28, 2014
    Role: Principal Investigator
    The Impact of Tolerance in the Newborn on Lentiviral Infection
    NIH R01AI090677Jul 2, 2010 - Jun 30, 2015
    Role: Principal Investigator
    Bay Area Hepatitis C Cooperative Research Center
    NIH U19AI088790Jun 15, 2010 - May 31, 2015
    Role: Principal Investigator
    Interruption of maternal-fetal transmission of HIV
    NIH R01AI084109Sep 5, 2009 - Aug 31, 2014
    Role: Principal Investigator
    HIV Proteomic Center for Host-Viral Response Characterization
    NIH P01DA026134Sep 30, 2008 - May 31, 2012
    Role: Co-Investigator
    Clinical and Transtional Science Institute
    NIH KL2RR024130Sep 30, 2006 - Jun 30, 2016
    Role: Principal Investigator
    Clinical and Transtional Science Institute
    NIH TL1RR024129Sep 30, 2006 - Jun 30, 2016
    Role: Principal Investigator
    Clinical and Translational Science Institute
    NIH UL1RR024131Sep 30, 2006 - Jun 30, 2016
    Role: Principal Investigator
    Anti-Gag Antibodies and Enhancement of Lentiviral Disease Progression
    NIH R21AI068583Jul 1, 2006 - Jun 30, 2009
    Role: Principal Investigator
    NIH Director's Pioneer Award (RMI)
    NIH DP1OD000329Sep 30, 2004 - Jul 31, 2010
    Role: Principal Investigator
    Beckman Coulter BioMek 2000 Workstation and Accessories
    NIH S10RR016959Apr 1, 2002 - Mar 31, 2003
    Role: Principal Investigator
    MOFLO TM HIGH PERFORMANCE FLOW CYTOMETER
    NIH S10RR013768Apr 1, 2000 - Mar 31, 2002
    Role: Principal Investigator
    Assessing Laboratory Correlates of Immune Protection
    NIH R01AI047062Feb 1, 2000 - Dec 31, 2008
    Role: Principal Investigator
    HUMAN IMMUNE CELL MATURATION DURING ONTOGENY AND INFECTI
    NIH/NIAID P01AI045865Sep 30, 1999 - Aug 31, 2003
    Role: Co-Investigator
    Thymic Function in Adults With HIV-1 Disease
    NIH U01AI043864Mar 1, 1999 - Mar 31, 2010
    Role: Principal Investigator
    THYMIC FUNCTION IN ADULTS WITH HIV1 DISEASE
    NIH R01AI043864Mar 1, 1999 - Feb 28, 2003
    Role: Principal Investigator
    SCID-HU ANIMAL MODEL FOR EVALUATING HIV THERAPIES
    NIH N01AI065309Jul 1, 1996 - Sep 29, 2000
    Role: Principal Investigator
    HIV EFFECTS ON THE CENTRAL HEMATOLYMPHOID SYSTEM
    NIH R37AI040312Apr 1, 1996 - Feb 28, 2012
    Role: Principal Investigator
    HIV EFFECTS ON THE CENTRAL HEMATOLYMPHOID SYSTEM IN VIVO
    NIH R01AI040312Apr 1, 1996 - Jul 31, 2000
    Role: Principal Investigator
    DISCOVERY AND DEVELOPMENT OF THERAPEUTIC COMPOUNDS
    NIH R13CA060157Mar 18, 1993 - Mar 17, 1994
    Role: Principal Investigator
    HIV INFECTION IN THE SCID-HU MOUSE
    NIH R01AI029323Sep 30, 1989 - Jul 31, 1995
    Role: Principal Investigator
    California National Primate Research Center
    NIH P51RR000169Jun 1, 1975 - Apr 30, 2015
    Role: Co-Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000083Oct 1, 1974 - Nov 30, 2007
    Role: Co-Investigator

    Collapse ORNG Applications 
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    Collapse Websites
    Collapse In The News
    Collapse Student Projects

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Hanscombe KB, Morris DL, Noble JA, Dilthey AT, Tombleson P, Kaufman KM, Comeau M, Langefeld CD, Alarcon-Riquelme ME, Gaffney PM, Jacob CO, Sivils KL, Tsao BP, Alarcon GS, Brown EE, Croker J, Edberg J, Gilkeson G, James JA, Kamen DL, Kelly JA, McCune J, Merrill JT, Petri M, Ramsey-Goldman R, Reveille JD, Salmon JE, Scofield H, Utset T, Wallace DJ, Weisman MH, Kimberly RP, Harley JB, Lewis CM, Criswell LA, Vyse TJ. Genetic fine mapping of systemic lupus erythematosus MHC associations in Europeans and African Americans. Hum Mol Genet. 2018 Nov 01; 27(21):3813-3824. PMID: 30085094.
      View in: PubMed
    2. Chitre AS, Kattah MG, Rosli YY, Pao M, Deswal M, Deeks SG, Hunt PW, Abdel-Mohsen M, Montaner LJ, Kim CC, Ma A, Somsouk M, McCune JM. A20 upregulation during treated HIV disease is associated with intestinal epithelial cell recovery and function. PLoS Pathog. 2018 03; 14(3):e1006806. PMID: 29505600.
      View in: PubMed
    3. Vasquez JJ, Hussien R, Aguilar-Rodriguez B, Junger H, Dobi D, Henrich TJ, Thanh C, Gibson E, Hogan LE, McCune J, Hunt PW, Stoddart CA, Laszik ZG. Elucidating the Burden of HIV in Tissues Using Multiplexed Immunofluorescence and In Situ Hybridization: Methods for the Single-Cell Phenotypic Characterization of Cells Harboring HIV In Situ. J Histochem Cytochem. 2018 Jun; 66(6):427-446. PMID: 29462571.
      View in: PubMed
    4. Anzinger JJ, Butterfield TR, Gouillou M, McCune JM, Crowe SM, Palmer CS. Glut1 Expression Level on Inflammatory Monocytes is Associated With Markers of Cardiovascular Disease Risk in HIV-Infected Individuals. J Acquir Immune Defic Syndr. 2018 02 01; 77(2):e28-e30. PMID: 28961681.
      View in: PubMed
    5. Méndez-Lagares G, Lu D, Chen C, Terrault N, Segal MR, Khalili M, Monto A, Shen H, Manos MM, Lanier LL, Ryan JC, McCune JM, Hartigan-O'Connor DJ. Memory T Cell Proliferation before Hepatitis C Virus Therapy Predicts Antiviral Immune Responses and Treatment Success. J Immunol. 2018 02 01; 200(3):1124-1132. PMID: 29263212.
      View in: PubMed
    6. Henrich TJ, Hatano H, Bacon O, Hogan LE, Rutishauser R, Hill A, Kearney MF, Anderson EM, Buchbinder SP, Cohen SE, Abdel-Mohsen M, Pohlmeyer CW, Fromentin R, Hoh R, Liu AY, McCune JM, Spindler J, Metcalf-Pate K, Hobbs KS, Thanh C, Gibson EA, Kuritzkes DR, Siliciano RF, Price RW, Richman DD, Chomont N, Siliciano JD, Mellors JW, Yukl SA, Blankson JN, Liegler T, Deeks SG. HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study. PLoS Med. 2017 Nov; 14(11):e1002417. PMID: 29112956.
      View in: PubMed
    7. Méndez-Lagares G, Lu D, Merriam D, Baker CA, Villinger F, Van Rompay KKA, McCune JM, Hartigan-O'Connor DJ. IL-21 Therapy Controls Immune Activation and Maintains Antiviral CD8+ T Cell Responses in Acute Simian Immunodeficiency Virus Infection. AIDS Res Hum Retroviruses. 2017 Nov; 33(S1):S81-S92. PMID: 29140110.
      View in: PubMed
    8. Palmer CS, Duette GA, Wagner MCE, Henstridge DC, Saleh S, Pereira C, Zhou J, Simar D, Lewin SR, Ostrowski M, McCune JM, Crowe SM. Metabolically active CD4+ T cells expressing Glut1 and OX40 preferentially harbor HIV during in vitro infection. FEBS Lett. 2017 10; 591(20):3319-3332. PMID: 28892135.
      View in: PubMed
    9. Estes JD, Kityo C, Ssali F, Swainson L, Makamdop KN, Del Prete GQ, Deeks SG, Luciw PA, Chipman JG, Beilman GJ, Hoskuldsson T, Khoruts A, Anderson J, Deleage C, Jasurda J, Schmidt TE, Hafertepe M, Callisto SP, Pearson H, Reimann T, Schuster J, Schoephoerster J, Southern P, Perkey K, Shang L, Wietgrefe SW, Fletcher CV, Lifson JD, Douek DC, McCune JM, Haase AT, Schacker TW. Defining total-body AIDS-virus burden with implications for curative strategies. Nat Med. 2017 Nov; 23(11):1271-1276. PMID: 28967921.
      View in: PubMed
    10. Cavrois M, Banerjee T, Mukherjee G, Raman N, Hussien R, Rodriguez BA, Vasquez J, Spitzer MH, Lazarus NH, Jones JJ, Ochsenbauer C, McCune JM, Butcher EC, Arvin AM, Sen N, Greene WC, Roan NR. Mass Cytometric Analysis of HIV Entry, Replication, and Remodeling in Tissue CD4+ T Cells. Cell Rep. 2017 07 25; 20(4):984-998. PMID: 28746881.
      View in: PubMed
    11. Langefeld CD, Ainsworth HC, Cunninghame Graham DS, Kelly JA, Comeau ME, Marion MC, Howard TD, Ramos PS, Croker JA, Morris DL, Sandling JK, Almlöf JC, Acevedo-Vásquez EM, Alarcón GS, Babini AM, Baca V, Bengtsson AA, Berbotto GA, Bijl M, Brown EE, Brunner HI, Cardiel MH, Catoggio L, Cervera R, Cucho-Venegas JM, Dahlqvist SR, D'Alfonso S, Da Silva BM, de la Rúa Figueroa I, Doria A, Edberg JC, Endreffy E, Esquivel-Valerio JA, Fortin PR, Freedman BI, Frostegård J, García MA, de la Torre IG, Gilkeson GS, Gladman DD, Gunnarsson I, Guthridge JM, Huggins JL, James JA, Kallenberg CGM, Kamen DL, Karp DR, Kaufman KM, Kottyan LC, Kovács L, Laustrup H, Lauwerys BR, Li QZ, Maradiaga-Ceceña MA, Martín J, McCune JM, McWilliams DR, Merrill JT, Miranda P, Moctezuma JF, Nath SK, Niewold TB, Orozco L, Ortego-Centeno N, Petri M, Pineau CA, Pons-Estel BA, Pope J, Raj P, Ramsey-Goldman R, Reveille JD, Russell LP, Sabio JM, Aguilar-Salinas CA, Scherbarth HR, Scorza R, Seldin MF, Sjöwall C, Svenungsson E, Thompson SD, Toloza SMA, Truedsson L, Tusié-Luna T, Vasconcelos C, Vilá LM, Wallace DJ, Weisman MH, Wither JE, Bhangale T, Oksenberg JR, Rioux JD, Gregersen PK, Syvänen AC, Rönnblom L, Criswell LA, Jacob CO, Sivils KL, Tsao BP, Schanberg LE, Behrens TW, Silverman ED, Alarcón-Riquelme ME, Kimberly RP, Harley JB, Wakeland EK, Graham RR, Gaffney PM, Vyse TJ. Transancestral mapping and genetic load in systemic lupus erythematosus. Nat Commun. 2017 07 17; 8:16021. PMID: 28714469.
      View in: PubMed
    12. Vujkovic-Cvijin I, Rutishauser RL, Pao M, Hunt PW, Lynch SV, McCune JM, Somsouk M. Limited engraftment of donor microbiome via one-time fecal microbial transplantation in treated HIV-infected individuals. Gut Microbes. 2017 09 03; 8(5):440-450. PMID: 28541799.
      View in: PubMed
    13. Rutishauser RL, Hartogensis W, Deguit CD, Krone M, Hoh R, Hecht FM, Pilcher CD, Bacchetti P, Deeks SG, Hunt PW, McCune JM. Early and Delayed Antiretroviral Therapy Results in Comparable Reductions in CD8+ T Cell Exhaustion Marker Expression. AIDS Res Hum Retroviruses. 2017 07; 33(7):658-667. PMID: 28335609.
      View in: PubMed
    14. Trang K, Raposo RA, Lowe MM, Krow-Lucal ER, Yonemoto W, Cabido VD, SenGupta D, McCune JM. Relative mRNA Expression Levels of Restriction Factors and Antiviral Genes in Fetal and Adult Human Monocytes and Monocyte-Derived Macrophages. Viral Immunol. 2017 04; 30(3):142-148. PMID: 28151065.
      View in: PubMed
    15. Bronevetsky Y, Burt TD, McCune JM. Lin28b Regulates Fetal Regulatory T Cell Differentiation through Modulation of TGF-ß Signaling. J Immunol. 2016 12 01; 197(11):4344-4350. PMID: 27793996.
      View in: PubMed
    16. Shastri R, Shah G, Wang P, Cagnoli P, Schmidt-Wilcke T, McCune J, Harris R, Sundgren P. MR Diffusion Tractography to Identify and Characterize Microstructural White Matter Tract Changes in Systemic Lupus Erythematosus Patients. Acad Radiol. 2016 11; 23(11):1431-1440. PMID: 27746120.
      View in: PubMed
    17. McCune JM. Henry Kunkel and the teaching of patient-oriented research. Clin Immunol. 2016 11; 172:27-28. PMID: 27538773.
      View in: PubMed
    18. Palmer CS, Anzinger JJ, Butterfield TR, McCune JM, Crowe SM. A Simple Flow Cytometric Method to Measure Glucose Uptake and Glucose Transporter Expression for Monocyte Subpopulations in Whole Blood. J Vis Exp. 2016 08 12; (114). PMID: 27584036.
      View in: PubMed
    19. Deeks SG, Lewin SR, Ross AL, Ananworanich J, Benkirane M, Cannon P, Chomont N, Douek D, Lifson JD, Lo YR, Kuritzkes D, Margolis D, Mellors J, Persaud D, Tucker JD, Barre-Sinoussi F, Alter G, Auerbach J, Autran B, Barouch DH, Behrens G, Cavazzana M, Chen Z, Cohen ÉA, Corbelli GM, Eholié S, Eyal N, Fidler S, Garcia L, Grossman C, Henderson G, Henrich TJ, Jefferys R, Kiem HP, McCune J, Moodley K, Newman PA, Nijhuis M, Nsubuga MS, Ott M, Palmer S, Richman D, Saez-Cirion A, Sharp M, Siliciano J, Silvestri G, Singh J, Spire B, Taylor J, Tolstrup M, Valente S, van Lunzen J, Walensky R, Wilson I, Zack J. International AIDS Society global scientific strategy: towards an HIV cure 2016. Nat Med. 2016 08; 22(8):839-50. PMID: 27400264.
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    20. Deleage C, Schuetz A, Alvord WG, Johnston L, Hao XP, Morcock DR, Rerknimitr R, Fletcher JL, Puttamaswin S, Phanuphak N, Dewar R, McCune JM, Sereti I, Robb M, Kim JH, Schacker TW, Hunt P, Lifson JD, Ananworanich J, Estes JD. Impact of early cART in the gut during acute HIV infection. JCI Insight. 2016 Jul 07; 1(10). PMID: 27446990.
      View in: PubMed
    21. Younes SA, Freeman ML, Mudd JC, Shive CL, Reynaldi A, Panigrahi S, Estes JD, Deleage C, Lucero C, Anderson J, Schacker TW, Davenport MP, McCune JM, Hunt PW, Lee SA, Serrano-Villar S, Debernardo RL, Jacobson JM, Canaday DH, Sekaly RP, Rodriguez B, Sieg SF, Lederman MM. IL-15 promotes activation and expansion of CD8+ T cells in HIV-1 infection. J Clin Invest. 2016 07 01; 126(7):2745-56. PMID: 27322062.
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    22. Ramirez CM, Sinclair E, Epling L, Lee SA, Jain V, Hsue PY, Hatano H, Conn D, Hecht FM, Martin JN, McCune JM, Deeks SG, Hunt PW. Immunologic profiles distinguish aviremic HIV-infected adults. AIDS. 2016 06 19; 30(10):1553-62. PMID: 26854811.
      View in: PubMed
    23. Deleage C, Wietgrefe SW, Del Prete G, Morcock DR, Hao XP, Piatak M, Bess J, Anderson JL, Perkey KE, Reilly C, McCune JM, Haase AT, Lifson JD, Schacker TW, Estes JD. Defining HIV and SIV Reservoirs in Lymphoid Tissues. Pathog Immun. 2016; 1(1):68-106. PMID: 27430032.
      View in: PubMed
    24. Lederman MM, Cannon PM, Currier JS, June CH, Kiem HP, Kuritzkes DR, Lewin SR, Margolis DM, McCune JM, Mellors JW, Schacker TW, Sekaly RP, Tebas P, Walker BD, Douek DC. A Cure for HIV Infection: "Not in My Lifetime" or "Just Around the Corner"? Pathog Immun. 2016; 1(1):154-164. PMID: 27668293.
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    25. Vujkovic-Cvijin I, Swainson LA, Chu SN, Ortiz AM, Santee CA, Petriello A, Dunham RM, Fadrosh DW, Lin DL, Faruqi AA, Huang Y, Apetrei C, Pandrea I, Hecht FM, Pilcher CD, Klatt NR, Brenchley JM, Lynch SV, McCune JM. Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques. Cell Rep. 2015 Nov 24; 13(8):1589-97. PMID: 26586432; PMCID: PMC4782968.
    26. Ladell K, Hazenberg MD, Fitch M, Emson C, McEvoy-Hein Asgarian BK, Mold JE, Miller C, Busch R, Price DA, Hellerstein MK, McCune JM. Continuous Antigenic Stimulation of DO11.10 TCR Transgenic Mice in the Presence or Absence of IL-1ß: Possible Implications for Mechanisms of T Cell Depletion in HIV Disease. J Immunol. 2015 Nov 01; 195(9):4096-105. PMID: 26416271.
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    27. Baker CA, Swainson L, Lin DL, Wong S, Hartigan-O'Connor DJ, Lifson JD, Tarantal AF, McCune JM. Exposure to SIV in utero results in reduced viral loads and altered responsiveness to postnatal challenge. Sci Transl Med. 2015 Aug 12; 7(300):300ra125. PMID: 26268312.
      View in: PubMed
    28. PrabhuDas M, Bonney E, Caron K, Dey S, Erlebacher A, Fazleabas A, Fisher S, Golos T, Matzuk M, McCune JM, Mor G, Schulz L, Soares M, Spencer T, Strominger J, Way SS, Yoshinaga K. Immune mechanisms at the maternal-fetal interface: perspectives and challenges. Nat Immunol. 2015 Apr; 16(4):328-34. PMID: 25789673.
      View in: PubMed
    29. Somsouk M, Estes JD, Deleage C, Dunham RM, Albright R, Inadomi JM, Martin JN, Deeks SG, McCune JM, Hunt PW. Gut epithelial barrier and systemic inflammation during chronic HIV infection. AIDS. 2015 Jan 02; 29(1):43-51. PMID: 25387317; PMCID: PMC4444362.
    30. Moniuszko M, Liyanage NP, Doster MN, Parks RW, Grubczak K, Lipinska D, McKinnon K, Brown C, Hirsch V, Vaccari M, Gordon S, Pegu P, Fenizia C, Flisiak R, Grzeszczuk A, Dabrowska M, Robert-Guroff M, Silvestri G, Stevenson M, McCune J, Franchini G. Glucocorticoid treatment at moderate doses of SIVmac251-infected rhesus macaques decreases the frequency of circulating CD14+CD16++ monocytes but does not alter the tissue virus reservoir. AIDS Res Hum Retroviruses. 2015 Jan; 31(1):115-26. PMID: 24432835; PMCID: PMC4287193.
    31. Somsouk M, Dunham RM, Cohen M, Albright R, Abdel-Mohsen M, Liegler T, Lifson J, Piatak M, Gorelick R, Huang Y, Wu Y, Hsue PY, Martin JN, Deeks SG, McCune JM, Hunt PW. The immunologic effects of mesalamine in treated HIV-infected individuals with incomplete CD4+ T cell recovery: a randomized crossover trial. PLoS One. 2014; 9(12):e116306. PMID: 25545673; PMCID: PMC4283685.
    32. Palmer CS, Anzinger JJ, Zhou J, Gouillou M, Landay A, Jaworowski A, McCune JM, Crowe SM. Glucose transporter 1-expressing proinflammatory monocytes are elevated in combination antiretroviral therapy-treated and untreated HIV+ subjects. J Immunol. 2014 Dec 01; 193(11):5595-603. PMID: 25367121.
      View in: PubMed
    33. Seu L, Ortiz GM, Burt TD, Deeks SG, Martin JN, McCune JM. Levels of circulating myeloid subpopulations and of heme oxygenase-1 do not predict CD4(+) T cell recovery after the initiation of antiretroviral therapy for HIV disease. AIDS Res Ther. 2014; 11:27. PMID: 25180041; PMCID: PMC4150425.
    34. Cockerham LR, Jain V, Sinclair E, Glidden DV, Hartogenesis W, Hatano H, Hunt PW, Martin JN, Pilcher CD, Sekaly R, McCune JM, Hecht FM, Deeks SG. Programmed death-1 expression on CD4? and CD8? T cells in treated and untreated HIV disease. AIDS. 2014 Jul 31; 28(12):1749-58. PMID: 24871455.
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    35. Krow-Lucal ER, McCune JM. Distinct functional programs in fetal T and myeloid lineages. Front Immunol. 2014; 5:314. PMID: 25071775; PMCID: PMC4083242.
    36. Batchelder CA, Duru N, Lee CI, Baker CA, Swainson L, Mccune JM, Tarantal AF. Myeloid-lymphoid ontogeny in the rhesus monkey (Macaca mulatta). Anat Rec (Hoboken). 2014 Aug; 297(8):1392-406. PMID: 24867874; PMCID: PMC4120262.
    37. Serrano-Villar S, Sainz T, Lee SA, Hunt PW, Sinclair E, Shacklett BL, Ferre AL, Hayes TL, Somsouk M, Hsue PY, Van Natta ML, Meinert CL, Lederman MM, Hatano H, Jain V, Huang Y, Hecht FM, Martin JN, McCune JM, Moreno S, Deeks SG. HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality. PLoS Pathog. 2014 May; 10(5):e1004078. PMID: 24831517; PMCID: PMC4022662.
    38. Lee SA, Sinclair E, Jain V, Huang Y, Epling L, Van Natta M, Meinert CL, Martin JN, McCune JM, Deeks SG, Lederman MM, Hecht FM, Hunt PW. Low proportions of CD28- CD8+ T cells expressing CD57 can be reversed by early ART initiation and predict mortality in treated HIV infection. J Infect Dis. 2014 Aug 01; 210(3):374-82. PMID: 24585893; PMCID: PMC4110459.
    39. Byakwaga H, Boum Y, Huang Y, Muzoora C, Kembabazi A, Weiser SD, Bennett J, Cao H, Haberer JE, Deeks SG, Bangsberg DR, McCune JM, Martin JN, Hunt PW. The kynurenine pathway of tryptophan catabolism, CD4+ T-cell recovery, and mortality among HIV-infected Ugandans initiating antiretroviral therapy. J Infect Dis. 2014 Aug 01; 210(3):383-91. PMID: 24585899; PMCID: PMC4148610.
    40. Lee SA, Sinclair E, Hatano H, Hsue PY, Epling L, Hecht FM, Bangsberg DR, Martin JN, McCune JM, Deeks SG, Hunt PW. Impact of HIV on CD8+ T cell CD57 expression is distinct from that of CMV and aging. PLoS One. 2014; 9(2):e89444. PMID: 24586783; PMCID: PMC3937334.
    41. Krow-Lucal ER, Kim CC, Burt TD, McCune JM. Distinct functional programming of human fetal and adult monocytes. Blood. 2014 Mar 20; 123(12):1897-904. PMID: 24518760; PMCID: PMC3962163.
    42. Lowe MM, Mold JE, Kanwar B, Huang Y, Louie A, Pollastri MP, Wang C, Patel G, Franks DG, Schlezinger J, Sherr DH, Silverstone AE, Hahn ME, McCune JM. Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production. PLoS One. 2014; 9(2):e87877. PMID: 24498387; PMCID: PMC3912126.
    43. Dunham RM, Vujkovic-Cvijin I, Yukl SA, Broadhurst MJ, Loke P, Albright RG, Wong JK, Lederman MM, Somsouk M, Hunt PW, Martin JN, Deeks SG, McCune JM. Discordance between peripheral and colonic markers of inflammation during suppressive ART. J Acquir Immune Defic Syndr. 2014 Feb 01; 65(2):133-41. PMID: 24121758; PMCID: PMC3997573.
    44. Palmer CS, Ostrowski M, Gouillou M, Tsai L, Yu D, Zhou J, Henstridge DC, Maisa A, Hearps AC, Lewin SR, Landay A, Jaworowski A, McCune JM, Crowe SM. Increased glucose metabolic activity is associated with CD4+ T-cell activation and depletion during chronic HIV infection. AIDS. 2014 Jan 28; 28(3):297-309. PMID: 24335483; PMCID: PMC4293200.
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