Joseph "Mike" McCune, MD, PhD

InstitutionUniversity of California San Francisco
Address1001 Potrero Ave
San Francisco CA 94110
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    Collapse Biography 
    Collapse Education and Training
    Stanford University Medical College, Palo Alto, CAPost-Doc Fellow/Scholar1988Pathology
    University of California, San Francisco Clinical Fellowship 1986Infectious Disease
    University of California, San FranciscoResidency 1984Internal Medicine
    Cornell University Medical College, New York, NYM.D.1982Medicine
    The Rockefeller University, New York, NYPh.D.1981Cell Biology/Immunology
    Harvard College, Cambridge, MAA.B.1975Biochemistry

    Collapse Overview 
    Collapse Overview
    Joseph ("Mike") McCune is a professor of medicine at the University of California, San Francisco (UCSF). He received his AB degree from Harvard College in 1975, his PhD degree from Rockefeller University in 1981, and his MD degree from Cornell University Medical College in 1982. He completed his residency in internal medicine in 1984 and did fellowship training in infectious diseases at UCSF. He is board certified in internal medicine.

    The McCune lab has been involved for many years in the analysis of HIV pathogenesis, prevention, treatment, and cure. Dr. McCune started to treat patients with HIV disease as a resident in internal medicine at UCSF in 1982 and has been involved in the HIV/AIDS research field ever since. This work included postdoctoral studies at Stanford, exploring the fusogenic properties of the HIV envelope protein and developing the first humanized mouse model (the SCID-hu mouse) capable of multilineage human hematopoiesis and receptive to infection with primary isolates of HIV. He then co-founded the companies SyStemix (in 1988) and Progenesys (and 1991), serving as Scientific Director and leading research efforts to find better ways – including antiviral medications and hematopoietic stem cell-based gene therapy – to treat HIV disease. In 1995, Dr. McCune returned to academia, first as an investigator at the Gladstone Institute of Virology and Immunology and then (from 2006-2016) as the Chief of the Division of Experimental Medicine (which he founded) at UCSF. Concomitantly, he was the founding PI (and Senior Associate Dean) of the Clinical and Translational Sciences Institute at UCSF (from 2005-08). In recent years, he has helped to form multidisciplinary, collaborative research teams to find a cure for HIV disease. Throughout this time, he has actively mentored graduate students and postdoctoral fellows, many of whom have gone on to successful careers in academia or biotech/pharma.

    Dr. McCune’s studies have led to the publication of over 200 peer-reviewed articles, and he is the holder of 20 patents and inventions. He is a member of many scientific and professional societies, including the American Society for Clinical Investigation, the American Association of Physicians, and the Henry Kunkel Society. He has served on the editorial boards of Virology and the Journal of the Acquired Immune Deficiency Syndrome. He was awarded the Elizabeth Glaser Pediatric AIDS Foundation Scientist Award in 1996, the Burroughs Wellcome Fund Clinical Scientist Award in Translational Research in 2000, a MERIT Award from the NIH in 2001, the NIH Director’s Pioneer Award in 2004, and the Holly Smith Award for Exceptional Service to the School of Medicine in 2016. He was also selected to give the UCSF Academic Senate Faculty Research Lecture (on Translational Science) in 2013.

    Collapse Research 
    Collapse Research Activities and Funding
    Interferon-independent mechanisms of malaria restriction by helper T cells
    NIH R21AI114916Sep 1, 2015 - Aug 31, 2017
    Role: Principal Investigator
    The impact of TB co-infection on the reservoir of persistent HIV in vivo
    NIH/NIAID R21AI116295Aug 1, 2015 - Jul 31, 2017
    Role: Principal Investigator
    Timing of ART and homeostasis of the persistent HIV reservoir in the adult
    NIH/NIAID R01AI116368Feb 4, 2015 - Jan 31, 2020
    Role: Principal Investigator
    Novel flow cytometry-based assay for HIV-infected cells
    NIH R21AI110143Dec 1, 2013 - Nov 30, 2015
    Role: Principal Investigator
    Layering of the human immune system, viral infections, and childhood asthma
    NIH R01AI100082Aug 21, 2012 - Jul 31, 2017
    Role: Principal Investigator
    DARE: Delaney AIDS Research Enterprise to find a cure.
    NIH/NIAID U19AI096109Jul 8, 2011 - Jun 30, 2016
    Role: Principal Investigator
    Human immune system layering and the neonatal response to vaccines
    NIH R21AI094009Mar 1, 2011 - Feb 28, 2014
    Role: Principal Investigator
    The Impact of Tolerance in the Newborn on Lentiviral Infection
    NIH R01AI090677Jul 2, 2010 - Jun 30, 2015
    Role: Principal Investigator
    Bay Area Hepatitis C Cooperative Research Center
    NIH U19AI088790Jun 15, 2010 - May 31, 2015
    Role: Principal Investigator
    Interruption of maternal-fetal transmission of HIV
    NIH R01AI084109Sep 5, 2009 - Aug 31, 2014
    Role: Principal Investigator
    HIV Proteomic Center for Host-Viral Response Characterization
    NIH P01DA026134Sep 30, 2008 - May 31, 2012
    Role: Co-Investigator
    Clinical and Transtional Science Institute
    NIH KL2RR024130Sep 30, 2006 - Jun 30, 2016
    Role: Principal Investigator
    Clinical and Transtional Science Institute
    NIH TL1RR024129Sep 30, 2006 - Jun 30, 2016
    Role: Principal Investigator
    Clinical and Translational Science Institute
    NIH UL1RR024131Sep 30, 2006 - Jun 30, 2016
    Role: Principal Investigator
    Anti-Gag Antibodies and Enhancement of Lentiviral Disease Progression
    NIH R21AI068583Jul 1, 2006 - Jun 30, 2009
    Role: Principal Investigator
    NIH Director's Pioneer Award (RMI)
    NIH DP1OD000329Sep 30, 2004 - Jul 31, 2010
    Role: Principal Investigator
    Beckman Coulter BioMek 2000 Workstation and Accessories
    NIH S10RR016959Apr 1, 2002 - Mar 31, 2003
    Role: Principal Investigator
    NIH S10RR013768Apr 1, 2000 - Mar 31, 2002
    Role: Principal Investigator
    Assessing Laboratory Correlates of Immune Protection
    NIH R01AI047062Feb 1, 2000 - Dec 31, 2008
    Role: Principal Investigator
    NIH/NIAID P01AI045865Sep 30, 1999 - Aug 31, 2003
    Role: Co-Investigator
    Thymic Function in Adults With HIV-1 Disease
    NIH U01AI043864Mar 1, 1999 - Mar 31, 2010
    Role: Principal Investigator
    NIH R01AI043864Mar 1, 1999 - Feb 28, 2003
    Role: Principal Investigator
    NIH N01AI065309Jul 1, 1996 - Sep 29, 2000
    Role: Principal Investigator
    NIH R37AI040312Apr 1, 1996 - Feb 28, 2012
    Role: Principal Investigator
    NIH R01AI040312Apr 1, 1996 - Jul 31, 2000
    Role: Principal Investigator
    NIH R13CA060157Mar 18, 1993 - Mar 17, 1994
    Role: Principal Investigator
    NIH R01AI029323Sep 30, 1989 - Jul 31, 1995
    Role: Principal Investigator
    California National Primate Research Center
    NIH P51RR000169Jun 1, 1975 - Apr 30, 2015
    Role: Co-Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000083Oct 1, 1974 - Nov 30, 2007
    Role: Co-Investigator

    Collapse ORNG Applications 
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    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. McCune M. Henry Kunkel and the teaching of patient-oriented research. Clin Immunol. 2016 Nov; 172:27-28. PMID: 27538773.
      View in: PubMed
    2. Ladell K, Hazenberg MD, Fitch M, Emson C, McEvoy-Hein Asgarian BK, Mold JE, Miller C, Busch R, Price DA, Hellerstein MK, McCune M. Continuous Antigenic Stimulation of DO11.10 TCR Transgenic Mice in the Presence or Absence of IL-1ß: Possible Implications for Mechanisms of T Cell Depletion in HIV Disease. J Immunol. 2015 Nov 01; 195(9):4096-105. PMID: 26416271.
      View in: PubMed
    3. Loke P, Favre D, Hunt PW, Leung JM, Kanwar B, Martin JN, Deeks SG, McCune M. Correlating cellular and molecular signatures of mucosal immunity that distinguish HIV controllers from noncontrollers. Blood. 2010 Apr 15; 115(15):e20-32. PMID: 20160163; PMCID: PMC2858476.
    4. Naeger DM, Martin JN, Sinclair E, Hunt PW, Bangsberg DR, Hecht F, Hsue P, McCune M, Deeks SG. Cytomegalovirus-specific T cells persist at very high levels during long-term antiretroviral treatment of HIV disease. PLoS One. 2010 Jan 29; 5(1):e8886. PMID: 20126452; PMCID: PMC2813282.
    5. Cheng LE, Kanwar B, Tcheurekdjian H, Grenert JP, Muskat M, Heyman MB, McCune M, Wara DW. Persistent systemic inflammation and atypical enterocolitis in patients with NEMO syndrome. Clin Immunol. 2009 Jul; 132(1):124-31. PMID: 19375390; PMCID: PMC2800791.
    6. Lederer S, Favre D, Walters KA, Proll S, Kanwar B, Kasakow Z, Baskin CR, Palermo R, McCune M, Katze MG. Transcriptional profiling in pathogenic and non-pathogenic SIV infections reveals significant distinctions in kinetics and tissue compartmentalization. PLoS Pathog. 2009 Feb; 5(2):e1000296. PMID: 19214219; PMCID: PMC2633618.
    7. Favre D, Lederer S, Kanwar B, Ma ZM, Proll S, Kasakow Z, Mold J, Swainson L, Barbour JD, Baskin CR, Palermo R, Pandrea I, Miller CJ, Katze MG, McCune M. Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection. PLoS Pathog. 2009 Feb; 5(2):e1000295. PMID: 19214220; PMCID: PMC2635016.
    8. Contreras X, Schweneker M, Chen CS, McCune M, Deeks SG, Martin J, Peterlin BM. Suberoylanilide hydroxamic acid reactivates HIV from latently infected cells. J Biol Chem. 2009 Mar 13; 284(11):6782-9. PMID: 19136668; PMCID: PMC2652322.
    9. Lozano Reina JM, Favre D, Kasakow Z, Mayau V, Nugeyre MT, Ka T, Faye A, Miller CJ, Scott-Algara D, McCune M, Barré-Sinoussi F, Diop OM, Müller-Trutwin MC. Gag p27-specific B- and T-cell responses in Simian immunodeficiency virus SIVagm-infected African green monkeys. J Virol. 2009 Mar; 83(6):2770-7. PMID: 19109377; PMCID: PMC2648264.
    10. Mold JE, Michaëlsson J, Burt TD, Muench MO, Beckerman KP, Busch MP, Lee TH, Nixon DF, McCune M. Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero. Science. 2008 Dec 05; 322(5907):1562-5. PMID: 19056990; PMCID: PMC2648820.
    11. Jones RB, Ndhlovu LC, Barbour JD, Sheth PM, Jha AR, Long BR, Wong JC, Satkunarajah M, Schweneker M, Chapman JM, Gyenes G, Vali B, Hyrcza MD, Yue FY, Kovacs C, Sassi A, Loutfy M, Halpenny R, Persad D, Spotts G, Hecht FM, Chun TW, McCune M, Kaul R, Rini JM, Nixon DF, Ostrowski MA. Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection. J Exp Med. 2008 Nov 24; 205(12):2763-79. PMID: 19001139; PMCID: PMC2585847.
    12. Hatano H, Delwart EL, Norris PJ, Lee TH, Dunn-Williams J, Hunt PW, Hoh R, Stramer SL, Linnen JM, McCune M, Martin JN, Busch MP, Deeks SG. Evidence for persistent low-level viremia in individuals who control human immunodeficiency virus in the absence of antiretroviral therapy. J Virol. 2009 Jan; 83(1):329-35. PMID: 18945778; PMCID: PMC2612329.