Linda Giudice, MD, PhD

Title(s)Professor, Ob/Gyn, Reproductive Sciences
SchoolSchool of Medicine
Address513 Parnassus Ave, HSE, #1600
San Francisco CA 94143
Phone415-502-4742
ORCID ORCID Icon0000-0002-1677-0822 Additional info
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    Other Positions
    Title(s)Obstetrics, Gynecology and Reproductive Sciences


    Collapse Biography 
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    Stanford UniversityM.D.1982School of Medicine

    Collapse Overview 
    Collapse Overview
    Linda C. Giudice, MD, PhD is Distinguished Professor, Chair Emerita, and the Robert B. Jaffe MD Endowed Professor in the Reproductive Sciences in the Department of Obstetrics, Gynecology and Reproductive Sciences at the University of California, San Francisco (UCSF). She is a biochemist and reproductive endocrinologist specializing in endometriosis and infertility. Her research focuses on human endometrial function and regeneration, genetics and epigenetics of endometriosis, placental-uterine interactions relevant to pregnancy outcomes, and evaluating the evidence of environmental impacts on reproductive health and human development. She has mentored over 250 students, fellows and faculty, authored > 300 peer-reviewed publications, and is co-editor of 6 textbooks on women’s health, reproductive environmental health, endocrinology, endometrium and endometriosis. She is Past-President of the American Society for Reproductive Medicine, the Society for Gynecologic Investigation, President of the World Endometriosis Society, President-elect of the International Federation of Fertility Societies, and Chair of the FIGO (International Federation of Gynecology and Obstetrics) Reproductive and Developmental Environmental Health Working Group. Dr. Giudice is on the UCSF Steering Committee on Women’s Precision Medicine, the March of Dimes Scientific Advisory Council, and is an elected member of the U.S. National Academy of Medicine and the U.S. National Academy of Inventors.

    Collapse Research 
    Collapse Research Activities and Funding
    UCSF Stanford Endometriosis Center for Discovery, Innovation, Training and Community Engagement
    NIH P01HD106414Aug 1, 2021 - Jul 31, 2026
    Role: Principal Investigator
    Integrative Analysis of Genomic, Epigenomic and Phenotypic Data for Disease Stratification of Endometriosis
    NIH R01HD089511Sep 26, 2016 - Apr 30, 2021
    Role: Principal Investigator
    Exploring HIV-Host Interactions in the Female Reproductive Tract
    NIH P01AI083050Sep 1, 2009 - Aug 31, 2015
    Role: Co-Principal Investigator
    Origins and Biological Consequences of Human Infertility
    NIH U54HD055764May 3, 2007 - Mar 31, 2017
    Role: Principal Investigator
    Center for Research, Innovation and Training in Reproduction and Infertility
    NIH P50HD055764Apr 1, 2007 - Mar 31, 2023
    Role: Principal Investigator
    Summit on Environmental Challenges to Reproductive Health and Fertility
    NIH R13ES015427Sep 15, 2006 - Aug 31, 2007
    Role: Principal Investigator
    Mentoring &Interdisciplinary Research in Women's Health
    NIH K12HD043452Sep 27, 2002 - Dec 31, 2008
    Role: Co-Principal Investigator
    Gordon Research Conference on Reproductive Tract Biology
    NIH R13HD042663Jun 19, 2002 - May 31, 2003
    Role: Principal Investigator
    Federally Registered Human Embryonic Stem Cell Center
    NIH R24RR017498May 1, 2002 - Jul 31, 2007
    Role: Principal Investigator
    Role of IGF-II in Human Trophoblast-Decidua Interactions
    NIH U01HD042298Apr 1, 2002 - Mar 31, 2008
    Role: Principal Investigator
    HYPOXIA, IGFBP-1, AND HUMAN FETAL GROWTH
    NIH R01HD036732Mar 1, 2000 - Aug 31, 2004
    Role: Principal Investigator
    Women's Reproductive Health Research
    NIH K12HD001262Sep 30, 1998 - Jun 30, 2025
    Role: Co-Principal Investigator
    Gonadal and Endometrial Function in Human Reproduction
    NIH U54HD031398Apr 7, 1997 - Mar 31, 2008
    Role: Co-Principal Investigator
    ROLE OF IGF IN HUMAN OVARY
    NIH R01HD031579May 1, 1994 - Sep 30, 2008
    Role: Principal Investigator
    INSULIN-LIKE GROWTH FACTOR SYSTEM IN OVIDUCT
    NIH R03HD028079May 1, 1991 - Apr 30, 1993
    Role: Principal Investigator
    IGF BINDING PROTEINS AND HUMAN ENDOMETRIUM
    NIH R01HD025220Apr 1, 1990 - Jul 31, 2002
    Role: Principal Investigator
    GENE EXPRESSION IN ENDOMETRIUM
    NIH R29HD025220Apr 1, 1990 - Mar 31, 1996
    Role: Principal Investigator
    General Clinical Research Center
    NIH M01RR000070Dec 1, 1978 - Nov 30, 2011
    Role: Co-Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A positive ReceptivaDx result for BCL6 does not correlate with abnormal ERA results or decreased expression of receptivity-associated markers: two sides of the endometrial receptivity coin in fertility evaluation and treatment. F S Sci. 2024 Oct 15. Huang D, Flynn E, Almonte-Loya A, Davidson B, Chan M, Casillas A, Irwin JC, Fragiadakis GK, Cakmak H, Combes AJ, Cedars MI, Sirota M, Giudice LC. PMID: 39419175.
      View in: PubMed   Mentions:    Fields:    
    2. Radiology State-of-the-art Review: Endometriosis Imaging Interpretation and Reporting. Radiology. 2024 Sep; 312(3):e233482. VanBuren W, Feldman M, Shenoy-Bhangle AS, Sakala MD, Young S, Chamie LP, Giudice L, Hindman NM, Tong A, Rabban JT, Yano M, Kilcoyne A, Dave HD, Poder L, Kho RM, Burnett TL, Khan Z, King C, Shen L, Colak C, Burk KS, Andrieu PIC, Franco IVP, Glanc P, Kielar AZ, Taffel MT, Kania LM, Bonde A, Pectasides M, Arif-Tiwari H, Laifer-Narin S, Nicola R, Jha P. PMID: 39287524.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Identifying therapeutic candidates for endometriosis through a transcriptomics-based drug repositioning approach. iScience. 2024 Apr 19; 27(4):109388. Oskotsky TT, Bhoja A, Bunis D, Le BL, Tang AS, Kosti I, Li C, Houshdaran S, Sen S, Vallvé-Juanico J, Wang W, Arthurs E, Govil A, Mahoney L, Lang L, Gaudilliere B, Stevenson DK, Irwin JC, Giudice LC, McAllister SL, Sirota M. PMID: 38510116; PMCID: PMC10952035.
      View in: PubMed   Mentions: 2  
    4. Two-year efficacy and safety of relugolix combination therapy in women with endometriosis-associated pain: SPIRIT open-label extension study. Hum Reprod. 2024 Mar 01; 39(3):526-537. Becker CM, Johnson NP, As-Sanie S, Arjona Ferreira JC, Abrao MS, Wilk K, Imm SJ, Mathur V, Perry JS, Wagman RB, Giudice LC. PMID: 38243752; PMCID: PMC10905503.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    5. Time for global health policy and research leaders to prioritize endometriosis. Nat Commun. 2023 Dec 04; 14(1):8028. Giudice LC, Horne AW, Missmer SA. PMID: 38049392; PMCID: PMC10696045.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    6. A Plain Language Summary to learn about relugolix combination therapy for the treatment of pain associated with endometriosis. Pain Manag. 2023 Nov; 13(11):631-640. Giudice LC, As-Sanie S, Arjona Ferreira JC, Becker CM, Abrao MS, Lessey BA, Dynowski K, Wilk K, Li Y, Mathur V, Wagman RB, Johnson NP. PMID: 37982388.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Endometriosis in the era of precision medicine and impact on sexual and reproductive health across the lifespan and in diverse populations. FASEB J. 2023 09; 37(9):e23130. Giudice LC, Oskotsky TT, Falako S, Opoku-Anane J, Sirota M. PMID: 37641572; PMCID: PMC10503213.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    8. Global endometrial DNA methylation analysis reveals insights into mQTL regulation and associated endometriosis disease risk and endometrial function. Commun Biol. 2023 08 16; 6(1):780. Mortlock S, Houshdaran S, Kosti I, Rahmioglu N, Nezhat C, Vitonis AF, Andrews SV, Grosjean P, Paranjpe M, Horne AW, Jacoby A, Lager J, Opoku-Anane J, Vo KC, Manvelyan E, Sen S, Ghukasyan Z, Collins F, Santamaria X, Saunders P, Kober K, McRae AF, Terry KL, Vallvé-Juanico J, Becker C, Rogers PAW, Irwin JC, Zondervan K, Montgomery GW, Missmer S, Sirota M, Giudice L. PMID: 37587191; PMCID: PMC10432557.
      View in: PubMed   Mentions: 3  Translation:HumansCells
    9. B-cell lymphoma 6 expression significantly differs by the uterine preparation method used for frozen embryo transfer. Fertil Steril. 2023 08; 120(2):305-311. Huang D, Chan M, Solomon M, Cedars MI, Giudice LC, Cakmak H. PMID: 37085097.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Leveraging electronic health records to identify risk factors for recurrent pregnancy loss across two medical centers: a case-control study. Res Sq. 2023 Mar 31. Roger J, Xie F, Costello J, Tang A, Liu J, Oskotsky T, Woldemariam S, Kosti I, Le B, Snyder MP, Giudice LC, Torgerson D, Shaw GM, Stevenson DK, Rajkovic A, Glymour MM, Aghaeepour N, Cakmak H, Lathi RB, Sirota M. PMID: 36993325; PMCID: PMC10055527.
      View in: PubMed   Mentions:
    11. The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions. Nat Genet. 2023 03; 55(3):423-436. Rahmioglu N, Mortlock S, Ghiasi M, Møller PL, Stefansdottir L, Galarneau G, Turman C, Danning R, Law MH, Sapkota Y, Christofidou P, Skarp S, Giri A, Banasik K, Krassowski M, Lepamets M, Marciniak B, Nõukas M, Perro D, Sliz E, Sobalska-Kwapis M, Thorleifsson G, Topbas-Selcuki NF, Vitonis A, Westergaard D, Arnadottir R, Burgdorf KS, Campbell A, Cheuk CSK, Clementi C, Cook J, De Vivo I, DiVasta A, Dorien O, Donoghue JF, Edwards T, Fontanillas P, Fung JN, Geirsson RT, Girling JE, Harkki P, Harris HR, Healey M, Heikinheimo O, Holdsworth-Carson S, Hostettler IC, Houlden H, Houshdaran S, Irwin JC, Jarvelin MR, Kamatani Y, Kennedy SH, Kepka E, Kettunen J, Kubo M, Kulig B, Kurra V, Laivuori H, Laufer MR, Lindgren CM, MacGregor S, Mangino M, Martin NG, Matalliotaki C, Matalliotakis M, Murray AD, Ndungu A, Nezhat C, Olsen CM, Opoku-Anane J, Padmanabhan S, Paranjpe M, Peters M, Polak G, Porteous DJ, Rabban J, Rexrode KM, Romanowicz H, Saare M, Saavalainen L, Schork AJ, Sen S, Shafrir AL, Siewierska-Górska A, Slomka M, Smith BH, Smolarz B, Szaflik T, Szyllo K, Takahashi A, Terry KL, Tomassetti C, Treloar SA, Vanhie A, Vincent K, Vo KC, Werring DJ, Zeggini E, Zervou MI, DBDS Genomic Consortium, FinnGen Study, FinnGen Endometriosis Taskforce, Celmatix Research Team, 23andMe Research Team, Adachi S, Buring JE, Ridker PM, D'Hooghe T, Goulielmos GN, Hapangama DK, Hayward C, Horne AW, Low SK, Martikainen H, Chasman DI, Rogers PAW, Saunders PT, Sirota M, Spector T, Strapagiel D, Tung JY, Whiteman DC, Giudice LC, Velez-Edwards DR, Uimari O, Kraft P, Salumets A, Nyholt DR, Mägi R, Stefansson K, Becker CM, Yurttas-Beim P, Steinthorsdottir V, Nyegaard M, Missmer SA, Montgomery GW, Morris AP, Zondervan KT. PMID: 36914876; PMCID: PMC10042257.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    12. Systematic review of climate change effects on reproductive health. Fertil Steril. 2022 08; 118(2):215-223. Segal TR, Giudice LC. PMID: 35878942.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansPHPublic Health
    13. Once daily oral relugolix combination therapy versus placebo in patients with endometriosis-associated pain: two replicate phase 3, randomised, double-blind, studies (SPIRIT 1 and 2). Lancet. 2022 06 18; 399(10343):2267-2279. Giudice LC, As-Sanie S, Arjona Ferreira JC, Becker CM, Abrao MS, Lessey BA, Brown E, Dynowski K, Wilk K, Li Y, Mathur V, Warsi QA, Wagman RB, Johnson NP. PMID: 35717987.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    14. Response to Boulicault et al. (2022) from women in the field. Hum Fertil (Camb). 2022 12; 25(5):1003-1004. Gore AC, Giudice LC, Flaws JA, Hunt PA. PMID: 35686468.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Commentary on the climate crisis and Women's health: Time for action. Int J Gynaecol Obstet. 2023 02; 160(2):455-456. Giudice LC. PMID: 35608325.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Transcriptomic analysis supports collective endometrial cell migration in the pathogenesis of adenomyosis. Reprod Biomed Online. 2022 09; 45(3):519-530. Zhai J, Li S, Sen S, Vallvé-Juanico J, Irwin JC, Vo KC, Wan J, Du Y, Chen ZJ, Giudice LC. PMID: 35773139; PMCID: PMC9976941.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    17. The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans. Science. 2022 05 13; 376(6594):eabl4896. Tabula Sapiens Consortium*, Jones RC, Karkanias J, Krasnow MA, Pisco AO, Quake SR, Salzman J, Yosef N, Bulthaup B, Brown P, Harper W, Hemenez M, Ponnusamy R, Salehi A, Sanagavarapu BA, Spallino E, Aaron KA, Concepcion W, Gardner JM, Kelly B, Neidlinger N, Wang Z, Crasta S, Kolluru S, Morri M, Tan SY, Travaglini KJ, Xu C, Alcántara-Hernández M, Almanzar N, Antony J, Beyersdorf B, Burhan D, Calcuttawala K, Carter MM, Chan CKF, Chang CA, Chang S, Colville A, Culver RN, Cvijovic I, D'Amato G, Ezran C, Galdos FX, Gillich A, Goodyer WR, Hang Y, Hayashi A, Houshdaran S, Huang X, Irwin JC, Jang S, Juanico JV, Kershner AM, Kim S, Kiss B, Kong W, Kumar ME, Kuo AH, Li B, Loeb GB, Lu WJ, Mantri S, Markovic M, McAlpine PL, de Morree A, Mrouj K, Mukherjee S, Muser T, Neuhöfer P, Nguyen TD, Perez K, Puluca N, Qi Z, Rao P, Raquer-McKay H, Schaum N, Scott B, Seddighzadeh B, Segal J, Sen S, Sikandar S, Spencer SP, Steffes LC, Subramaniam VR, Swarup A, Swift M, Van Treuren W, Trimm E, Veizades S, Vijayakumar S, Vo KC, Vorperian SK, Wang W, Weinstein HNW, Winkler J, Wu TTH, Xie J, Yung AR, Zhang Y, Detweiler AM, Mekonen H, Neff NF, Sit RV, Tan M, Yan J, Bean GR, Charu V, Forgó E, Martin BA, Ozawa MG, Silva O, Toland A, Vemuri VNP, Afik S, Awayan K, Botvinnik OB, Byrne A, Chen M, Dehghannasiri R, Gayoso A, Granados AA, Li Q, Mahmoudabadi G, McGeever A, Olivieri JE, Park M, Ravikumar N, Stanley G, Tan W, Tarashansky AJ, Vanheusden R, Wang P, Wang S, Xing G, Dethlefsen L, Ezran C, Gillich A, Hang Y, Ho PY, Irwin JC, Jang S, Leylek R, Liu S, Maltzman JS, Metzger RJ, Phansalkar R, Sasagawa K, Sinha R, Song H, Swarup A, Trimm E, Veizades S, Wang B, Beachy PA, Clarke MF, Giudice LC, Huang FW, Huang KC, Idoyaga J, Kim SK, Kuo CS, Nguyen P, Rando TA, Red-Horse K, Reiter J, Relman DA, Sonnenburg JL, Wu A, Wu SM, Wyss-Coray T. PMID: 35549404; PMCID: PMC9812260.
      View in: PubMed   Mentions: 294     Fields:    Translation:HumansCells
    18. Deep immunophenotyping reveals endometriosis is marked by dysregulation of the mononuclear phagocytic system in endometrium and peripheral blood. BMC Med. 2022 04 15; 20(1):158. Vallvé-Juanico J, George AF, Sen S, Thomas R, Shin MG, Kushnoor D, Vásquez JJ, Vo KC, Irwin JC, Roan NR, Combes AJ, Giudice LC. PMID: 35421980; PMCID: PMC9011995.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    19. Nutritional interventions to ameliorate the effect of endocrine disruptors on human reproductive health: A semi-structured review from FIGO. Int J Gynaecol Obstet. 2022 Jun; 157(3):489-501. Corbett GA, Lee S, Woodruff TJ, Hanson M, Hod M, Charlesworth AM, Giudice L, Conry J, McAuliffe FM, International Federation of Gynecology and Obstetrics (FIGO) Committee on Impact of Pregnancy on Lon. PMID: 35122246; PMCID: PMC9305939.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    20. Whole-Tissue Deconvolution and scRNAseq Analysis Identify Altered Endometrial Cellular Compositions and Functionality Associated With Endometriosis. Front Immunol. 2021; 12:788315. Bunis DG, Wang W, Vallvé-Juanico J, Houshdaran S, Sen S, Ben Soltane I, Kosti I, Vo KC, Irwin JC, Giudice LC, Sirota M. PMID: 35069565; PMCID: PMC8766492.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    21. Climate change, women's health, and the role of obstetricians and gynecologists in leadership. Int J Gynaecol Obstet. 2021 Dec; 155(3):345-356. Giudice LC, Llamas-Clark EF, DeNicola N, Pandipati S, Zlatnik MG, Decena DCD, Woodruff TJ, Conry JA, FIGO Committee on Climate Change and Toxic Environmental Exposures. PMID: 34694628; PMCID: PMC9298078.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsPHPublic Health
    22. Environmental impact on reproductive health and risk mitigating strategies. Curr Opin Obstet Gynecol. 2021 08 01; 33(4):343-349. Giudice LC. PMID: 34039883.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansPHPublic Health
    23. Elevated levels of perfluoroalkyl substances in breast cancer patients within the Greater Manila Area. Chemosphere. 2022 Jan; 286(Pt 1):131545. Velarde MC, Chan AFO, Sajo MEJV, Zakharevich I, Melamed J, Uy GLB, Teves JMY, Corachea AJM, Valparaiso AP, Macalindong SS, Cabaluna ND, Dofitas RB, Giudice LC, Gerona RR. PMID: 34293563.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    24. In Silico, In Vitro, and In Vivo Analysis Identifies Endometrial Circadian Clock Genes in Recurrent Implantation Failure. J Clin Endocrinol Metab. 2021 06 16; 106(7):2077-2091. Zhai J, Li S, Hu J, Gao M, Sun Y, Chen ZJ, Giudice LC, Du Y. PMID: 33619544; PMCID: PMC8502449.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    25. Endometrial function in women with polycystic ovary syndrome: a comprehensive review. Hum Reprod Update. 2021 04 21; 27(3):584-618. Palomba S, Piltonen TT, Giudice LC. PMID: 33302299.
      View in: PubMed   Mentions: 97     Fields:    Translation:Humans
    26. Randomized Trial of a Vaccine Regimen to Prevent Chronic HCV Infection. N Engl J Med. 2021 02 11; 384(6):541-549. Page K, Melia MT, Veenhuis RT, Winter M, Rousseau KE, Massaccesi G, Osburn WO, Forman M, Thomas E, Thornton K, Wagner K, Vassilev V, Lin L, Lum PJ, Giudice LC, Stein E, Asher A, Chang S, Gorman R, Ghany MG, Liang TJ, Wierzbicki MR, Scarselli E, Nicosia A, Folgori A, Capone S, Cox AL. PMID: 33567193; PMCID: PMC8367093.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    27. Could children born to mothers with COVID-19 be more prone to non-communicable diseases? Acta Paediatr. 2021 Apr; 110(4):1367-1368. Malamitsi-Puchner A, Briana DD, Giudice L, Di Renzo GC. PMID: 33438264; PMCID: PMC8013839.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    28. Genetic risk factors for endometriosis near estrogen receptor 1 and coexpression of genes in this region in endometrium. Mol Hum Reprod. 2021 01 22; 27(1). Marla S, Mortlock S, Houshdaran S, Fung J, McKinnon B, Holdsworth-Carson SJ, Girling JE, Rogers PAW, Giudice LC, Montgomery GW. PMID: 33394050; PMCID: PMC8453628.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    29. Patterns of sex hormone receptor expression in stimulated endometrium from oocyte donors. Hum Fertil (Camb). 2022 Oct; 25(4):662-669. Manvelyan E, Houshdaran S, Irwin JC, Giudice LC, Aghajanova L. PMID: 33464141.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    30. Eye to the Future in Adenomyosis Research. Semin Reprod Med. 2020 May; 38(2-03):197-200. Halvorson LM, Giudice LC, Stewart EA. PMID: 33307559.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    31. Standardizing definitions and reporting guidelines for the infertility core outcome set: an international consensus development study†  ‡. Hum Reprod. 2020 12 01; 35(12):2735-2745. Duffy JMN, Bhattacharya S, Bhattacharya S, Bofill M, Collura B, Curtis C, Evers JLH, Giudice LC, Farquharson RG, Franik S, Hickey M, Hull ML, Jordan V, Khalaf Y, Legro RS, Lensen S, Mavrelos D, Mol BW, Niederberger C, Ng EHY, Puscasiu L, Repping S, Sarris I, Showell M, Strandell A, Vail A, van Wely M, Vercoe M, Vuong NL, Wang AY, Wang R, Wilkinson J, Youssef MA, Farquhar CM, Core Outcome Measure for Infertility Trials (COMMIT) initiative, Abou-Setta AM, Aguilera JJ, AlAhwany H, Atanda OOA, Balkenende EME, Barnhart KT, Beebeejaun Y, Chambers GM, Chughtai AA, Cuevas-Sáiz I, Curtis C, D'Angelo A, Dubois DD, Duckitt K, Encinas C, Gerval MO, Giang NH, Gibreel A, Gingel LJ, Glanville EJ, Glujovsky D, Granne I, Griesinger G, Repromed DG, Hamzehgardeshi Z, Hirsch M, Horton M, Jain S, Perez MJ, Jones CA, Kamath MS, Knijnenburg J, Kostova E, La Marca A, Khac Le T, Leader A, Leeviers B, Chinese JL, Loto OM, Marks KL, Martinez-Vazquez RM, McTavish AR, Mills DJ, Nair RR, Nguyen DTP, Otter AS, Pacey AA, Rautakallio-Hokkanen S, Sadler LC, Sagle P, Schwarze JE, Shapiro HM, Simpson JL, Siristatidis CS, Sood A, Strawbridge C, Torrance HL, Tran CT, Votteler EL, Wang CC, Watson A, Yossry M. PMID: 33252643; PMCID: PMC7744157.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    32. Top 10 priorities for future infertility research: an international consensus development study†  ‡. Hum Reprod. 2020 12 01; 35(12):2715-2724. Duffy JMN, Adamson GD, Benson E, Bhattacharya S, Bhattacharya S, Bofill M, Brian K, Collura B, Curtis C, Evers JLH, Farquharson RG, Fincham A, Franik S, Giudice LC, Glanville E, Hickey M, Horne AW, Hull ML, Johnson NP, Jordan V, Khalaf Y, Knijnenburg JML, Legro RS, Lensen S, MacKenzie J, Mavrelos D, Mol BW, Morbeck DE, Nagels H, Ng EHY, Niederberger C, Otter AS, Puscasiu L, Rautakallio-Hokkanen S, Sadler L, Sarris I, Showell M, Stewart J, Strandell A, Strawbridge C, Vail A, van Wely M, Vercoe M, Vuong NL, Wang AY, Wang R, Wilkinson J, Wong K, Wong TY, Farquhar CM, Priority Setting Partnership for Infertility, AlAhwany H, Balaban O, Barton F, Beebeejaun Y, Boivin J, Bosteels JJA, Calhaz-Jorge C, D’Angelo A, F. Dann L, J. De Jonge C, du Mez E, A. Ferriani R, Gerval MO, J. Gingel L, Greenblatt EM, Hartshorne G, Helliwell C, Hughes LJ, Jo J, Jovanovic J, Kiesel L, Kietpeerakool C, Kostova E, Kucuk T, Kumar R, Lawrence RL, Lee N, Lindemann KE, Loto OM, Lutjen PJ, MacKinven M, Mascarenhas M, McLaughlin H, Mourad SM, Nguyen LK, Norman RJ, Olic M, Overfield KL, Parker-Harris M, Repping S, Rizzo R, Salacone P, Saunders CH, Sengupta R, Sfontouris IA, Silverman NR, Torrance HL, Uphoff EP, Wakeman SA, Wischmann T, Woodward BJ, Youssef MA. PMID: 33252677; PMCID: PMC7744161.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
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    37. Cellular Origins of Endometriosis: Towards Novel Diagnostics and Therapeutics. Semin Reprod Med. 2020 05; 38(2-03):201-215. Filby CE, Rombauts L, Montgomery GW, Giudice LC, Gargett CE. PMID: 33176364.
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    38. Adenomyosis: Mechanisms and Pathogenesis. Semin Reprod Med. 2020 May; 38(2-03):129-143. Zhai J, Vannuccini S, Petraglia F, Giudice LC. PMID: 33032339; PMCID: PMC7932680.
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    39. Multidimensional transcriptomic mapping of human endometrium at single-cell resolution. Nat Med. 2020 10; 26(10):1513-1514. Giudice LC. PMID: 32929267.
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    40. Cytotrophoblast extracellular vesicles enhance decidual cell secretion of immune modulators via TNFα. Development. 2020 09 08; 147(17). Taylor SK, Houshdaran S, Robinson JF, Gormley MJ, Kwan EY, Kapidzic M, Schilling B, Giudice LC, Fisher SJ. PMID: 32747437; PMCID: PMC7502596.
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    41. The global impact of COVID-19 on infertility services. Glob Reprod Health. 2020 Aug 13; 5. Ory SJ, Miller KA, Horton M, Giudice L. PMID: 34192216; PMCID: PMC7434007.
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    44. A Clarion Warning About Pregnancy Outcomes and the Climate Crisis. JAMA Netw Open. 2020 06 01; 3(6):e208811. Giudice LC. PMID: 32556255.
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    45. HIV efficiently infects T cells from the endometrium and remodels them to promote systemic viral spread. Elife. 2020 05 26; 9. Ma T, Luo X, George AF, Mukherjee G, Sen N, Spitzer TL, Giudice LC, Greene WC, Roan NR. PMID: 32452381; PMCID: PMC7250576.
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    46. Parallel studies of mucosal immunity in the reproductive and gastrointestinal mucosa of HIV-infected women. Am J Reprod Immunol. 2020 07; 84(1):e13246. Shanmugasundaram U, Critchfield JW, Giudice LC, Smith-McCune K, Greenblatt RM, Shacklett BL. PMID: 32301548; PMCID: PMC7302888.
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    47. Authors' Reply. J Minim Invasive Gynecol. 2020 Sep - Oct; 27(6):1427. Montgomery GW, Mortlock S, Giudice LC. PMID: 32339756.
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    48. Differential Effects of the Hormonal and Copper Intrauterine Device on the Endometrial Transcriptome. Sci Rep. 2020 04 23; 10(1):6888. Smith-McCune K, Thomas R, Averbach S, Seidman D, Takeda M, Houshdaran S, Giudice LC. PMID: 32327684; PMCID: PMC7181869.
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    49. Progestins Related to Progesterone and Testosterone Elicit Divergent Human Endometrial Transcriptomes and Biofunctions. Int J Mol Sci. 2020 Apr 09; 21(7). Houshdaran S, Chen JC, Vallvé-Juanico J, Balayan S, Vo KC, Smith-McCune K, Greenblatt RM, Irwin JC, Giudice LC. PMID: 32283828; PMCID: PMC7177488.
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    50. Seminal plasma promotes decidualization of endometrial stromal fibroblasts in vitro from women with and without inflammatory disorders in a manner dependent on interleukin-11 signaling. Hum Reprod. 2020 03 27; 35(3):617-640. George AF, Jang KS, Nyegaard M, Neidleman J, Spitzer TL, Xie G, Chen JC, Herzig E, Laustsen A, Marques de Menezes EG, Houshdaran S, Pilcher CD, Norris PJ, Jakobsen MR, Greene WC, Giudice LC, Roan NR. PMID: 32219408; PMCID: PMC7105328.
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    51. A Pilot Cancer-Phenome Biobanking System in a Low-Resource Southeast Asian Setting: The Philippine General Hospital Biobank Experience. Biopreserv Biobank. 2020 Jun; 18(3):180-188. Sajo MEJV, Teves JMY, Corachea AJM, Diaz LA, Chan AFO, Valparaiso AP, Dy Echo AVV, Macalindong SS, Uy GLB, Dofitas RB, Habana MAE, Gerona RR, Irwin JC, Giudice LC, Velarde MC. PMID: 32202927.
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    52. Macrophages display proinflammatory phenotypes in the eutopic endometrium of women with endometriosis with relevance to an infectious etiology of the disease. Fertil Steril. 2019 12; 112(6):1118-1128. Vallvé-Juanico J, Santamaria X, Vo KC, Houshdaran S, Giudice LC. PMID: 31843088; PMCID: PMC6944306.
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    53. Should Genetics Now Be Considered the Pre-eminent Etiologic Factor in Endometriosis? J Minim Invasive Gynecol. 2020 02; 27(2):280-286. Montgomery GW, Mortlock S, Giudice LC. PMID: 31683028; PMCID: PMC7863762.
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    54. Before the beginning: environmental exposures and reproductive and obstetrical outcomes. Fertil Steril. 2019 10; 112(4):613-621. Segal TR, Giudice LC. PMID: 31561863.
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    55. Reprint of: Pathogenesis and pathophysiology of endometriosis. Fertil Steril. 2019 10; 112(4 Suppl1):e153-e161. Burney RO, Giudice LC. PMID: 31623726.
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    56. 25 historic papers: an ASRM 75th birthday gift from Fertility and Sterility. Fertil Steril. 2019 10; 112(4 Suppl1):e2-e27. Niederberger C, Pellicer A, Simon C, Kathrins M, Goldstein M, Sigman M, Schlegel PN, Munné S, Gardner DK, Cobo A, Coutifaris C, Donnez J, Taylor HS, Giudice LC, Fauser BCJM, Lindheim SR, Rosenwaks Z, Casper RF, de Ziegler D, Gibbons WE, Paulson RJ, Laufer N, Klock SC, Mendola P, Sauer MV. PMID: 31623734.
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    57. The endometrial immune environment of women with endometriosis. Hum Reprod Update. 2019 09 11; 25(5):564-591. Vallvé-Juanico J, Houshdaran S, Giudice LC. PMID: 31424502; PMCID: PMC6737540.
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    58. Assessing research gaps and unmet needs in endometriosis. Am J Obstet Gynecol. 2019 08; 221(2):86-94. As-Sanie S, Black R, Giudice LC, Gray Valbrun T, Gupta J, Jones B, Laufer MR, Milspaw AT, Missmer SA, Norman A, Taylor RN, Wallace K, Williams Z, Yong PJ, Nebel RA. PMID: 30790565.
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    59. Clinical diagnosis of endometriosis: a call to action. Am J Obstet Gynecol. 2019 04; 220(4):354.e1-354.e12. Agarwal SK, Chapron C, Giudice LC, Laufer MR, Leyland N, Missmer SA, Singh SS, Taylor HS. PMID: 30625295.
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    60. Establishing the global working group on Reproductive and Developmental Environmental Health (RDEH): practicum of a global resource. Glob Reprod Health. 2018 Sep; 3(3). Power AM, Woodruff TJ, Conry JA, Giudice LC. PMID: 31245658; PMCID: PMC6594703.
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    62. Forty years of IVF. Fertil Steril. 2018 07 15; 110(2):185-324.e5. Niederberger C, Pellicer A, Cohen J, Gardner DK, Palermo GD, O'Neill CL, Chow S, Rosenwaks Z, Cobo A, Swain JE, Schoolcraft WB, Frydman R, Bishop LA, Aharon D, Gordon C, New E, Decherney A, Tan SL, Paulson RJ, Goldfarb JM, Brännström M, Donnez J, Silber S, Dolmans MM, Simpson JL, Handyside AH, Munné S, Eguizabal C, Montserrat N, Izpisua Belmonte JC, Trounson A, Simon C, Tulandi T, Giudice LC, Norman RJ, Hsueh AJ, Sun Y, Laufer N, Kochman R, Eldar-Geva T, Lunenfeld B, Ezcurra D, D'Hooghe T, Fauser BCJM, Tarlatzis BC, Meldrum DR, Casper RF, Fatemi HM, Devroey P, Galliano D, Wikland M, Sigman M, Schoor RA, Goldstein M, Lipshultz LI, Schlegel PN, Hussein A, Oates RD, Brannigan RE, Ross HE, Pennings G, Klock SC, Brown S, Van Steirteghem A, Rebar RW, LaBarbera AR. PMID: 30053940.
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    63. Long-Term Outcomes of Elagolix in Women With Endometriosis: Results From Two Extension Studies. Obstet Gynecol. 2018 07; 132(1):147-160. Surrey E, Taylor HS, Giudice L, Lessey BA, Abrao MS, Archer DF, Diamond MP, Johnson NP, Watts NB, Gallagher JC, Simon JA, Carr BR, Dmowski WP, Leyland N, Singh SS, Rechberger T, Agarwal SK, Duan WR, Schwefel B, Thomas JW, Peloso PM, Ng J, Soliman AM, Chwalisz K. PMID: 29889764.
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    64. Evaluation, validation and refinement of noninvasive diagnostic biomarkers for endometriosis (ENDOmarker): A protocol to phenotype bio-specimens for discovery and validation. Contemp Clin Trials. 2018 05; 68:1-6. Barnhart K, Giudice L, Young S, Thomas T, Diamond MP, Segars J, Youssef WA, Krawetz S, Santoro N, Eisenberg E, Zhang H, NICHD Cooperative Reproductive Medicine Network. PMID: 29524590; PMCID: PMC5899676.
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    66. Effects of noncavity-distorting fibroids on endometrial gene expression and function. Biol Reprod. 2017 Oct 01; 97(4):564-576. Aghajanova L, Houshdaran S, Irwin JC, Giudice LC. PMID: 29025102; PMCID: PMC6279121.
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    67. Stromal fibroblasts from perimenopausal endometrium exhibit a different transcriptome than those from the premenopausal endometrium. Biol Reprod. 2017 Sep 01; 97(3):387-399. Erikson DW, Barragan F, Piltonen TT, Chen JC, Balayan S, Irwin JC, Giudice LC. PMID: 29024986; PMCID: PMC5803759.
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    68. Meta-signature of human endometrial receptivity: a meta-analysis and validation study of transcriptomic biomarkers. Sci Rep. 2017 08 30; 7(1):10077. Altmäe S, Koel M, Võsa U, Adler P, Suhorutšenko M, Laisk-Podar T, Kukushkina V, Saare M, Velthut-Meikas A, Krjutškov K, Aghajanova L, Lalitkumar PG, Gemzell-Danielsson K, Giudice L, Simón C, Salumets A. PMID: 28855728; PMCID: PMC5577343.
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    69. Treatment of Endometriosis-Associated Pain with Elagolix, an Oral GnRH Antagonist. N Engl J Med. 2017 07 06; 377(1):28-40. Taylor HS, Giudice LC, Lessey BA, Abrao MS, Kotarski J, Archer DF, Diamond MP, Surrey E, Johnson NP, Watts NB, Gallagher JC, Simon JA, Carr BR, Dmowski WP, Leyland N, Rowan JP, Duan WR, Ng J, Schwefel B, Thomas JW, Jain RI, Chwalisz K. PMID: 28525302.
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    70. New Lessons about Endometriosis - Somatic Mutations and Disease Heterogeneity. N Engl J Med. 2017 05 11; 376(19):1881-1882. Montgomery GW, Giudice LC. PMID: 28489997.
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    71. Mucosal stromal fibroblasts markedly enhance HIV infection of CD4+ T cells. PLoS Pathog. 2017 02; 13(2):e1006163. Neidleman JA, Chen JC, Kohgadai N, Müller JA, Laustsen A, Thavachelvam K, Jang KS, Stürzel CM, Jones JJ, Ochsenbauer C, Chitre A, Somsouk M, Garcia MM, Smith JF, Greenblatt RM, Münch J, Jakobsen MR, Giudice LC, Greene WC, Roan NR. PMID: 28207890; PMCID: PMC5312882.
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    72. Effects of depot-medroxyprogesterone acetate on the immune microenvironment of the human cervix and endometrium: implications for HIV susceptibility. Mucosal Immunol. 2017 09; 10(5):1270-1278. Smith-McCune KK, Hilton JF, Shanmugasundaram U, Critchfield JW, Greenblatt RM, Seidman D, Averbach S, Giudice LC, Shacklett BL. PMID: 28051087; PMCID: PMC5496803.
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    73. World Endometriosis Society consensus on the classification of endometriosis. Hum Reprod. 2017 02; 32(2):315-324. Johnson NP, Hummelshoj L, Adamson GD, Keckstein J, Taylor HS, Abrao MS, Bush D, Kiesel L, Tamimi R, Sharpe-Timms KL, Rombauts L, Giudice LC, World Endometriosis Society Sao Paulo Consortium . PMID: 27920089.
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    74. Insights from imaging the implanting embryo and the uterine environment in three dimensions. Development. 2016 12 15; 143(24):4749-4754. Arora R, Fries A, Oelerich K, Marchuk K, Sabeur K, Giudice LC, Laird DJ. PMID: 27836961; PMCID: PMC5201036.
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    75. Challenging dogma: the endometrium has a microbiome with functional consequences! Am J Obstet Gynecol. 2016 12; 215(6):682-683. Giudice LC. PMID: 27725136.
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    76. Research Priorities for Endometriosis. Reprod Sci. 2017 02; 24(2):202-226. Rogers PA, Adamson GD, Al-Jefout M, Becker CM, D'Hooghe TM, Dunselman GA, Fazleabas A, Giudice LC, Horne AW, Hull ML, Hummelshoj L, Missmer SA, Montgomery GW, Stratton P, Taylor RN, Rombauts L, Saunders PT, Vincent K, Zondervan KT, WES/WERF Consortium for Research Priorities in Endometriosis. PMID: 27368878; PMCID: PMC5933154.
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    77. Environmental toxicants: hidden players on the reproductive stage. Fertil Steril. 2016 Sep 15; 106(4):791-4. Giudice LC. PMID: 27545021.
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    169. VEGF blockade inhibits angiogenesis and reepithelialization of endometrium. FASEB J. 2008 Oct; 22(10):3571-80. Fan X, Krieg S, Kuo CJ, Wiegand SJ, Rabinovitch M, Druzin ML, Brenner RM, Giudice LC, Nayak NR. PMID: 18606863; PMCID: PMC2537439.
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    172. Developmental competence of immature and failed/abnormally fertilized human oocytes in nuclear transfer. Reprod Biomed Online. 2008 May; 16(5):684-93. McElroy SL, Kee K, Tran N, Menses J, Giudice LC, Reijo Pera RA. PMID: 18492373.
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    174. Proceedings of the Summit on Environmental Challenges to Reproductive Health and Fertility: executive summary. Fertil Steril. 2008 Feb; 89(2 Suppl):e1-e20. Woodruff TJ, Carlson A, Schwartz JM, Giudice LC. PMID: 18308046.
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    179. The influence of hydrosalpinx on markers of endometrial receptivity. Semin Reprod Med. 2007 Nov; 25(6):476-82. Savaris RF, Giudice LC. PMID: 17960532.
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    227. Regulation of insulin-like growth factor-I and insulin-like growth factor binding protein-1 concentrations in preterm fetuses. Am J Obstet Gynecol. 2003 Feb; 188(2):485-91. Verhaeghe J, Van Herck E, Billen J, Moerman P, Van Assche FA, Giudice LC. PMID: 12592260.
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    228. Predictors of ovulatory failure in women with epilepsy. Ann Neurol. 2002 Dec; 52(6):704-11. Morrell MJ, Giudice L, Flynn KL, Seale CG, Paulson AJ, Doñe S, Flaster E, Ferin M, Sauer MV. PMID: 12447923.
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    229. Pregnancy-associated plasma protein A proteolytic activity is associated with the human placental trophoblast cell membrane. J Clin Endocrinol Metab. 2002 Nov; 87(11):5235-40. Sun IY, Overgaard MT, Oxvig C, Giudice LC. PMID: 12414897.
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    231. Emerging role of genomics in endometriosis research. Fertil Steril. 2002 Oct; 78(4):694-8. Taylor RN, Lundeen SG, Giudice LC. PMID: 12372442.
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    232. Substrate specificity of the metalloproteinase pregnancy-associated plasma protein-A (PAPP-A) assessed by mutagenesis and analysis of synthetic peptides: substrate residues distant from the scissile bond are critical for proteolysis. Biochem J. 2002 Oct 01; 367(Pt 1):31-40. Laursen LS, Overgaard MT, Nielsen CG, Boldt HB, Hopmann KH, Conover CA, Sottrup-Jensen L, Giudice LC, Oxvig C. PMID: 12241545; PMCID: PMC1222882.
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    233. Maternal-fetal conflict--lessons from a transgene. J Clin Invest. 2002 Aug; 110(3):307-9. Giudice LC. PMID: 12163449; PMCID: PMC151099.
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    234. Global gene profiling in human endometrium during the window of implantation. Endocrinology. 2002 Jun; 143(6):2119-38. Kao LC, Tulac S, Lobo S, Imani B, Yang JP, Germeyer A, Osteen K, Taylor RN, Lessey BA, Giudice LC. PMID: 12021176.
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    235. Identification and regulation of the IGFBP-4 protease and its physiological inhibitor in human trophoblasts and endometrial stroma: evidence for paracrine regulation of IGF-II bioavailability in the placental bed during human implantation. J Clin Endocrinol Metab. 2002 May; 87(5):2359-66. Giudice LC, Conover CA, Bale L, Faessen GH, Ilg K, Sun I, Imani B, Suen LF, Irwin JC, Christiansen M, Overgaard MT, Oxvig C. PMID: 11994388.
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    238. The molecular basis for implantation failure in endometriosis: on the road to discovery. Ann N Y Acad Sci. 2002 Mar; 955:252-64; discussion 293-5, 396-406. Giudice LC, Telles TL, Lobo S, Kao L. PMID: 11949953.
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    239. Prediction of the individual follicle-stimulating hormone threshold for gonadotropin induction of ovulation in normogonadotropic anovulatory infertility: an approach to increase safety and efficiency. Fertil Steril. 2002 Jan; 77(1):83-90. Imani B, Eijkemans MJ, Faessen GH, Bouchard P, Giudice LC, Fauser BC. PMID: 11779595.
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    240. Insulin-like growth factor-binding protein-1 in umbilical artery and vein of term fetuses with signs suggestive of distress during labor. J Endocrinol. 2001 Sep; 170(3):585-90. Verhaeghe J, Billen J, Giudice LC. PMID: 11524238.
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    241. Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: implications for the mechanism of IGFBP-4 proteolysis by PAPP-A. FEBS Lett. 2001 Aug 24; 504(1-2):36-40. Laursen LS, Overgaard MT, Søe R, Boldt HB, Sottrup-Jensen L, Giudice LC, Conover CA, Oxvig C. PMID: 11522292.
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    242. A potential role for insulin-like growth factor binding protein-4 proteolysis in the establishment of ovarian follicular dominance in cattle. Biol Reprod. 2001 Jul; 65(1):102-11. Rivera GM, Chandrasekher YA, Evans AC, Giudice LC, Fortune JE. PMID: 11420229.
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    243. Hypoxia regulates insulin-like growth factor-binding protein 1 in human fetal hepatocytes in primary culture: suggestive molecular mechanisms for in utero fetal growth restriction caused by uteroplacental insufficiency. J Clin Endocrinol Metab. 2001 Jun; 86(6):2653-9. Popovici RM, Lu M, Bhatia S, Faessen GH, Giaccia AJ, Giudice LC. PMID: 11397868.
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    244. Insulin-like growth factor (IGF)-II inhibition of endometrial stromal cell tissue inhibitor of metalloproteinase-3 and IGF-binding protein-1 suggests paracrine interactions at the decidua:trophoblast interface during human implantation. J Clin Endocrinol Metab. 2001 May; 86(5):2060-4. Irwin JC, Suen LF, Faessen GH, Popovici RM, Giudice LC. PMID: 11344207.
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    245. Pregnancy-associated plasma protein-a is the insulin-like growth factor binding protein-4 protease secreted by human ovarian granulosa cells and is a marker of dominant follicle selection and the corpus luteum. Endocrinology. 2001 May; 142(5):2155. Conover CA, Faessen GF, Ilg KE, Chandrasekher YA, Christiansen M, Overgaard MT, Oxvig C, Giudice LC. PMID: 11316785.
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    246. Tissue-specific alternate splicing of human telomerase reverse transcriptase (hTERT) influences telomere lengths during human development. Int J Cancer. 2001 Mar 01; 91(5):644-9. Ulaner GA, Hu JF, Vu TH, Giudice LC, Hoffman AR. PMID: 11267974.
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    247. Multiple pregnancies: what action should we take? Fertil Steril. 2001 Jan; 75(1):14-5; discussion 16-7. Paulson RJ, Ory SJ, Giudice LC, Schlaff WD, Santoro NF, Coddington CC. PMID: 11163807.
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    248. Insulin-like growth factor family in Graafian follicle development and function. J Soc Gynecol Investig. 2001 Jan-Feb; 8(1 Suppl Proceedings):S26-9. Giudice LC. PMID: 11223367.
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    249. Ovarian follicular concentrations of activin, follistatin, inhibin, insulin-like growth factor I (IGF-I), IGF-II, IGF-binding protein-2 (IGFBP-2), IGFBP-3, and vascular endothelial growth factor in spontaneous menstrual cycles of normal women of advanced reproductive age. J Clin Endocrinol Metab. 2000 Dec; 85(12):4520-5. Klein NA, Battaglia DE, Woodruff TK, Padmanabhan V, Giudice LC, Bremner WJ, Soules MR. PMID: 11134102.
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    250. Regulation of insulin-like growth factor-binding protein 1 by hypoxia and 3',5'-cyclic adenosine monophosphate is additive in HepG2 cells. J Clin Endocrinol Metab. 2000 Oct; 85(10):3821-7. Sugawara J, Tazuke SI, Suen LF, Powell DR, Kaper F, Giaccia AJ, Giudice LC. PMID: 11061545.
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    251. Discovery of new inducible genes in in vitro decidualized human endometrial stromal cells using microarray technology. Endocrinology. 2000 Sep; 141(9):3510-3. Popovici RM, Kao LC, Giudice LC. PMID: 10965925.
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    252. Regulation of insulin-like growth factor-binding protein-1 by nitric oxide under hypoxic conditions. J Clin Endocrinol Metab. 2000 Aug; 85(8):2714-21. Sugawara J, Suh DS, Faessen GH, Suen LF, Shibata T, Kaper F, Giaccia AJ, Giudice LC. PMID: 10946870.
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    253. Free androgen index and leptin are the most prominent endocrine predictors of ovarian response during clomiphene citrate induction of ovulation in normogonadotropic oligoamenorrheic infertility. J Clin Endocrinol Metab. 2000 Feb; 85(2):676-82. Imani B, Eijkemans MJ, de Jong FH, Payne NN, Bouchard P, Giudice LC, Fauser BC. PMID: 10690875.
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    254. Human placental trophoblasts secrete a disintegrin metalloproteinase very similar to the insulin-like growth factor binding protein-3 protease in human pregnancy serum. Endocrinology. 2000 Feb; 141(2):666-74. Irwin JC, Suen LF, Cheng BH, Martin R, Cannon P, Deal CL, Giudice LC. PMID: 10650948.
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    255. Regulation of telomerase by alternate splicing of human telomerase reverse transcriptase (hTERT) in normal and neoplastic ovary, endometrium and myometrium. Int J Cancer. 2000 Feb 01; 85(3):330-5. Ulaner GA, Hu JF, Vu TH, Oruganti H, Giudice LC, Hoffman AR. PMID: 10652422.
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    256. Potential biochemical markers of uterine receptivity. Hum Reprod. 1999 Dec; 14 Suppl 2:3-16. Giudice LC. PMID: 10690796.
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    257. Evidence that the insulin-like growth factor binding protein-4 protease in human ovarian follicular fluid is pregnancy associated plasma protein-A. J Clin Endocrinol Metab. 1999 Dec; 84(12):4742-5. Conover CA, Oxvig C, Overgaard MT, Christiansen M, Giudice LC. PMID: 10599745.
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    258. Role of the IGF system in trophoblast invasion and pre-eclampsia. Hum Reprod. 1999 Dec; 14 Suppl 2:90-6. Irwin JC, Suen LF, Martina NA, Mark SP, Giudice LC. PMID: 10690804.
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    259. Elevated serum levels of free insulin-like growth factor I in polycystic ovary syndrome. J Clin Endocrinol Metab. 1999 Sep; 84(9):3030-5. Thierry van Dessel HJ, Lee PD, Faessen G, Fauser BC, Giudice LC. PMID: 10487660.
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    260. The insulin-related ovarian regulatory system in health and disease. Endocr Rev. 1999 Aug; 20(4):535-82. Poretsky L, Cataldo NA, Rosenwaks Z, Giudice LC. PMID: 10453357.
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    261. Hypoxia and cAMP stimulate vascular endothelial growth factor (VEGF) in human endometrial stromal cells: potential relevance to menstruation and endometrial regeneration. J Clin Endocrinol Metab. 1999 Jun; 84(6):2245-8. Popovici RM, Irwin JC, Giaccia AJ, Giudice LC. PMID: 10372740.
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    262. Growth factor action on ovarian function in polycystic ovary syndrome. Endocrinol Metab Clin North Am. 1999 Jun; 28(2):325-39, vi. Giudice LC. PMID: 10352921.
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    263. Insulin-like growth factor-II mediates the steroidogenic and growth promoting actions of follicle stimulating hormone on human ovarian pre-antral follicles cultured in vitro. J Clin Endocrinol Metab. 1999 Apr; 84(4):1479-82. Yuan W, Giudice LC. PMID: 10199799.
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    264. Genes associated with embryonic attachment and implantation and the role of progesterone. J Reprod Med. 1999 Feb; 44(2 Suppl):165-71. Giudice LC. PMID: 11392027.
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    265. Roles of the insulinlike growth factor family in nonpregnant human endometrium and at the decidual: trophoblast interface. Semin Reprod Endocrinol. 1999; 17(1):13-21. Giudice LC, Irwin JC. PMID: 10406071.
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    266. Dysfunctional uterine bleeding. West J Med. 1998 Nov; 169(5):280-4. Chen BH, Giudice LC. PMID: 9830356; PMCID: PMC1305317.
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    267. Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts. Cancer Res. 1998 Sep 15; 58(18):4168-72. Ulaner GA, Hu JF, Vu TH, Giudice LC, Hoffman AR. PMID: 9751630.
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    268. Growth factor regulation of insulin-like growth factor binding protein secretion by cultured human granulosa-luteal cells. Fertil Steril. 1998 Sep; 70(3):535-40. Yap OW, Chandrasekher YA, Giudice LC. PMID: 9757886.
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    269. Hypoxia stimulates insulin-like growth factor binding protein 1 (IGFBP-1) gene expression in HepG2 cells: a possible model for IGFBP-1 expression in fetal hypoxia. Proc Natl Acad Sci U S A. 1998 Aug 18; 95(17):10188-93. Tazuke SI, Mazure NM, Sugawara J, Carland G, Faessen GH, Suen LF, Irwin JC, Powell DR, Giaccia AJ, Giudice LC. PMID: 9707622; PMCID: PMC21483.
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    270. Paracrine actions of insulin-like growth factors and IGF binding protein-1 in non-pregnant human endometrium and at the decidual-trophoblast interface. J Reprod Immunol. 1998 Aug; 39(1-2):133-48. Giudice LC, Mark SP, Irwin JC. PMID: 9786458.
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    271. Medical management of interstitial ectopic pregnancy: a case report and literature review. Hum Reprod. 1998 Jul; 13(7):1981-6. Fisch JD, Ortiz BH, Tazuke SI, Chitkara U, Giudice LC. PMID: 9740461.
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    272. Human granulosa cells use high density lipoprotein cholesterol for steroidogenesis. J Clin Endocrinol Metab. 1998 Mar; 83(3):983-91. Azhar S, Tsai L, Medicherla S, Chandrasekher Y, Giudice L, Reaven E. PMID: 9506760.
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    273. Status of current research on endometriosis. J Reprod Med. 1998 Mar; 43(3 Suppl):252-62. Giudice LC, Tazuke SI, Swiersz L. PMID: 9564658.
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    274. Insulin-like growth factor binding protein-1 binds to placental cytotrophoblast alpha5beta1 integrin and inhibits cytotrophoblast invasion into decidualized endometrial stromal cultures. Growth Horm IGF Res. 1998 Feb; 8(1):21-31. Irwin JC, Giudice LC. PMID: 10990441.
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    302. The insulin-like growth factor system in normal and abnormal human ovarian follicle development. Am J Med. 1995 Jan 16; 98(1A):48S-54S. Giudice LC. PMID: 7825641.
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    303. Circulating and ovarian IGF binding proteins: potential roles in normo-ovulatory cycles and in polycystic ovarian syndrome. Prog Growth Factor Res. 1995; 6(2-4):397-408. Giudice LC, van Dessel HJ, Cataldo NA, Chandrasekher YA, Yap OW, Fauser BC. PMID: 8817683.
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    304. Insulin-like growth factor system gene expression in human endometrium during the menstrual cycle. J Clin Endocrinol Metab. 1994 Dec; 79(6):1723-34. Zhou J, Dsupin BA, Giudice LC, Bondy CA. PMID: 7527408.
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    305. Insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), and proteolyzed IGFBP-3 in embryonic cavities in early human pregnancy: their potential relevance to maternal-embryonic and fetal interactions. J Clin Endocrinol Metab. 1994 Nov; 79(5):1249-55. Nonoshita LD, Wathen NC, Dsupin BA, Chard T, Giudice LC. PMID: 7525630.
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    306. The insulin-like growth factor system in human peritoneal fluid: its effects on endometrial stromal cells and its potential relevance to endometriosis. J Clin Endocrinol Metab. 1994 Nov; 79(5):1284-93. Giudice LC, Dsupin BA, Gargosky SE, Rosenfeld RG, Irwin JC. PMID: 7525631.
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    307. Identification of insulin-like growth factor-binding protein-3 (IGFBP-3) fragments and IGFBP-5 proteolytic activity in human seminal plasma: a comparison of normal and vasectomized patients. J Clin Endocrinol Metab. 1994 Nov; 79(5):1367-72. Lee KO, Oh Y, Giudice LC, Cohen P, Peehl DM, Rosenfeld RG. PMID: 7525634.
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    308. Growth factors and decidualization in vitro. Ann N Y Acad Sci. 1994 Sep 30; 734:7-18. Irwin JC, de las Fuentes L, Giudice LC. PMID: 7526767.
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    309. Patterns of matrix metalloproteinase expression in cycling endometrium imply differential functions and regulation by steroid hormones. J Clin Invest. 1994 Sep; 94(3):946-53. Rodgers WH, Matrisian LM, Giudice LC, Dsupin B, Cannon P, Svitek C, Gorstein F, Osteen KG. PMID: 8083380; PMCID: PMC295134.
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    310. Insulin-like growth factor-binding proteins in the human fetus: tissue-specific protein secretion, immunologic characterization, and gene expression. Am J Obstet Gynecol. 1994 Sep; 171(3):746-52. Pannier EM, Irwin JC, Giudice LC. PMID: 7522398.
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    311. Adnexal torsion: color Doppler diagnosis and laparoscopic treatment. Fertil Steril. 1994 Feb; 61(2):383-5. Gordon JD, Hopkins KL, Jeffrey RB, Giudice LC. PMID: 8299800.
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    312. Growth factors and growth modulators in human uterine endometrium: their potential relevance to reproductive medicine. Fertil Steril. 1994 Jan; 61(1):1-17. Giudice LC. PMID: 7507444.
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    313. Insulin-like growth factor (IGF), IGF binding protein (IGFBP), and IGF receptor gene expression and IGFBP synthesis in human uterine leiomyomata. Hum Reprod. 1993 Nov; 8(11):1796-806. Giudice LC, Irwin JC, Dsupin BA, Pannier EM, Jin IH, Vu TH, Hoffman AR. PMID: 7507128.
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    314. Insulin-like growth factor regulation of human endometrial stromal cell function: coordinate effects on insulin-like growth factor binding protein-1, cell proliferation and prolactin secretion. Regul Pept. 1993 Oct 20; 48(1-2):165-77. Irwin JC, de las Fuentes L, Dsupin BA, Giudice LC. PMID: 7505463.
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    315. Ethics of fetal tissue transplantation. West J Med. 1993 Sep; 159(3):400-7. Sanders LM, Giudice L, Raffin TA. PMID: 8236984; PMCID: PMC1011357.
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    316. The potential roles of intraovarian peptides in normal and abnormal mechanisms of reproductive physiology. Curr Opin Obstet Gynecol. 1993 Jun; 5(3):350-9. Giudice LC, Chandrasekher YA, Cataldo NA. PMID: 8329651.
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    317. Differential expression of messenger ribonucleic acids encoding insulin-like growth factors and their receptors in human uterine endometrium and decidua. J Clin Endocrinol Metab. 1993 May; 76(5):1115-22. Giudice LC, Dsupin BA, Jin IH, Vu TH, Hoffman AR. PMID: 8496300.
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    318. Insulin-like growth factor binding proteins in sera of pregnant nonhuman primates. Endocrinology. 1993 Apr; 132(4):1514-26. Giudice LC, Dsupin BA, De las Fuentes L, Gargosky SE, Rosenfeld RG, Zelinski-Wooten MB, Stouffer RL, Fazleabas AT. PMID: 7681762.
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    319. Proteolysis of IGFBP-3 may be a common regulatory mechanism of IGF action in vivo. Growth Regul. 1993 Mar; 3(1):91-5. Lamson G, Giudice LC, Cohen P, Liu F, Gargosky S, Müller HL, Oh Y, Wilson KF, Hintz RL, Rosenfeld RG. PMID: 7683546.
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    320. Expression and localization of matrilysin, a matrix metalloproteinase, in human endometrium during the reproductive cycle. Am J Obstet Gynecol. 1993 Jan; 168(1 Pt 1):253-60. Rodgers WH, Osteen KG, Matrisian LM, Navre M, Giudice LC, Gorstein F. PMID: 8420336.
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    321. Regulation of insulin-like growth factor binding protein production by human luteinizing granulosa cells cultured in defined medium. J Clin Endocrinol Metab. 1993 Jan; 76(1):207-15. Cataldo NA, Woodruff TK, Giudice LC. PMID: 7678423.
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    322. Comparison of functional response of rat, macaque, and human ovarian cells in hormonally defined medium. Biol Reprod. 1993 Jan; 48(1):68-76. Woodruff TK, Battaglia J, Bowdidge A, Molskness TA, Stouffer RL, Cataldo NA, Giudice LC, Orly J, Mather JP. PMID: 8418917.
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    323. Measurement and characterization of insulin-like growth factor binding protein-3 in human biological fluids: discrepancies between radioimmunoassay and ligand blotting. Endocrinology. 1992 Dec; 131(6):3051-60. Gargosky SE, Pham HM, Wilson KF, Liu F, Giudice LC, Rosenfeld RG. PMID: 1280211.
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    324. Local anesthesia with conscious sedation for laparoscopic intrafallopian transfer. Fertil Steril. 1992 Dec; 58(6):1240-2. Milki AA, Hardy RI, el Danasouri I, Giudice LC, Lamb EJ. PMID: 1459278.
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    325. Insulin-like growth factors and ovarian follicular development. Endocr Rev. 1992 Nov; 13(4):641-69. Giudice LC. PMID: 1281087.
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    326. Steroid and peptide regulation of insulin-like growth factor-binding proteins secreted by human endometrial stromal cells is dependent on stromal differentiation. J Clin Endocrinol Metab. 1992 Nov; 75(5):1235-41. Giudice LC, Dsupin BA, Irwin JC. PMID: 1385468.
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    327. Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma. J Clin Endocrinol Metab. 1992 Oct; 75(4):1046-53. Cohen P, Graves HC, Peehl DM, Kamarei M, Giudice LC, Rosenfeld RG. PMID: 1383255.
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    328. Insulin-like growth factor binding protein profiles in human ovarian follicular fluid correlate with follicular functional status. J Clin Endocrinol Metab. 1992 Apr; 74(4):821-9. Cataldo NA, Giudice LC. PMID: 1372322.
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    329. Follicular fluid insulin-like growth factor binding protein profiles in polycystic ovary syndrome. J Clin Endocrinol Metab. 1992 Mar; 74(3):695-7. Cataldo NA, Giudice LC. PMID: 1371292.
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    330. Identification of insulin-like growth factor binding proteins in human oviduct. Fertil Steril. 1992 Feb; 57(2):294-301. Giudice LC, Dsupin BA, Irwin JC, Eckert RL. PMID: 1370941.
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    331. Maternal insulin-like growth factor-binding protein messenger ribonucleic acid during rat pregnancy. Endocrinology. 1991 Dec; 129(6):3359-66. Donovan SM, Giudice LC, Murphy LJ, Hintz RL, Rosenfeld RG. PMID: 1720094.
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    332. Human granulosa contain messenger ribonucleic acids encoding insulin-like growth factor-binding proteins (IGFBPs) and secrete IGFBPs in culture. Fertil Steril. 1991 Sep; 56(3):475-80. Giudice LC, Milki AA, Milkowski DA, el Danasouri I. PMID: 1716597.
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    333. A simple assay for proteolysis of IGFBP-3. J Clin Endocrinol Metab. 1991 Jun; 72(6):1391-3. Lamson G, Giudice LC, Rosenfeld RG. PMID: 1709177.
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    334. Characterization of the steroid-dependence of insulin-like growth factor-binding protein-2 synthesis and mRNA expression in cultured human endometrial stromal cells. Hum Reprod. 1991 May; 6(5):632-40. Giudice LC, Milkowski DA, Fielder PJ, Irwin JC. PMID: 1719019.
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    335. Insulin-like growth factor binding proteins in human endometrium: steroid-dependent messenger ribonucleic acid expression and protein synthesis. J Clin Endocrinol Metab. 1991 Apr; 72(4):779-87. Giudice LC, Milkowski DA, Lamson G, Rosenfeld RG, Irwin JC. PMID: 1706350.
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    336. Insulin-like growth factor-II (IGF-II) and IGF binding proteins in human endometrium. Ann N Y Acad Sci. 1991; 626:295-307. Giudice LC, Lamson G, Rosenfeld RG, Irwin JC. PMID: 1711826.
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    337. Insulin-like growth factor binding proteins: structural and molecular relationships. Growth Factors. 1991; 5(1):19-28. Lamson G, Giudice LC, Rosenfeld RG. PMID: 1722987.
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    338. Clinical aspects of insulin-like growth factor binding proteins. Acta Endocrinol (Copenh). 1991; 124 Suppl 2:74-85. Cohen P, Fielder PJ, Hasegawa Y, Frisch H, Giudice LC, Rosenfeld RG. PMID: 1713010.
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    339. Identification of insulin-like growth factor-binding protein-3 (IGFBP-3) and IGFBP-2 in human follicular fluid. J Clin Endocrinol Metab. 1990 Nov; 71(5):1330-8. Giudice LC, Farrell EM, Pham H, Rosenfeld RG. PMID: 1699963.
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    340. Insulin-like growth factor binding proteins in maternal serum throughout gestation and in the puerperium: effects of a pregnancy-associated serum protease activity. J Clin Endocrinol Metab. 1990 Oct; 71(4):806-16. Giudice LC, Farrell EM, Pham H, Lamson G, Rosenfeld RG. PMID: 1698200.
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    341. Identification of insulin-like growth factor-binding protein-2 (IGF-BP-2) and a low molecular weight IGF-BP in human seminal plasma. J Clin Endocrinol Metab. 1990 Feb; 70(2):551-3. Rosenfeld RG, Pham H, Oh Y, Lamson G, Giudice LC. PMID: 1688870.
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    342. Insulinlike growth factor-binding proteins. Recent Prog Horm Res. 1990; 46:99-159; discussion 159-63. Rosenfeld RG, Lamson G, Pham H, Oh Y, Conover C, De Leon DD, Donovan SM, Ocrant I, Giudice L. PMID: 1704143.
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    343. Expression of two insulin-like growth factor-binding proteins in a human endometrial cancer cell line: structural, immunological, and genetic characterization. J Clin Endocrinol Metab. 1989 Oct; 69(4):852-9. Lamson G, Oh Y, Pham H, Giudice LC, Rosenfeld RG. PMID: 2550507.
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    344. Cryopreservation of embryos and ova. Fertil Steril. 1988 May; 49(5):743-64. Friedler S, Giudice LC, Lamb EJ. PMID: 3282929.
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    345. Angiographic arterial embolization to control hemorrhage in abdominal pregnancy: a case report. Obstet Gynecol. 1988 Mar; 71(3 Pt 2):456-9. Kivikoski AI, Martin C, Weyman P, Picus D, Giudice L. PMID: 3347434.
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    346. Pregnancy following nonsurgical donor ovum transfer to a functionally agonadal woman. Fertil Steril. 1987 Aug; 48(2):324-5. Sauer MV, Macaso TM, Ishida EH, Giudice L, Marshall JR, Buster JE. PMID: 3609344.
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    347. Clinical results of Stanford University's in vitro fertilization and embryo transfer program. J In Vitro Fert Embryo Transf. 1987 Jun; 4(3):188-9. Lamb EJ, Polansky F, Milki A, Giudice LC, Friedler S, Wu T, Shen E, Turner K, Ho L. PMID: 3611930.
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    348. Serum levels of CA-125 in patients with endometriosis: a preliminary report. Fertil Steril. 1986 Jun; 45(6):876-8. Giudice LC, Jacobs A, Pineda J, Bell CE, Lippmann L. PMID: 3458595.
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    349. The function of the common subunit of glycoprotein hormones. Biochem Soc Trans. 1978; 6(1):57-60. Pierce JG, Bloomfield GA, Giudice LC. PMID: 640204.
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    350. Separation of functional and non-functional beta subunits of thyrotropin preparations by polyacrylamide gel electrophoresis. Endocrinology. 1977 Sep; 101(3):776-81. Giudice LC, Pierce JG. PMID: 408127.
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    351. Studies on the disulfide bonds of glycoprotein hormones. Course of reduction of bovine luteinizing hormone, bovine thyroid-stimulating hormone, and their subunits. J Biol Chem. 1976 Oct 25; 251(20):6388-91. Pierce JG, Giudice LC, Reeve JR. PMID: 988020.
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    352. Studies on the disulfide bonds of glycoprotein hormones. Complete reduction and reoxidation of the disulfide bonds of the alpha subunit of bovine luteinizing hormone. J Biol Chem. 1976 Oct 25; 251(20):6392-9. Giudice LC, Pierce JG. PMID: 988021.
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    353. Structure and structure-function relationships in glycoprotein hormones. Ciba Found Symp. 1976; 41:225-50. Pierce JG, Faith MR, Giudice LC, Reeve JR. PMID: 780075.
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