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Linda Giudice, MD, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentOb/Gyn, Reproductive Sciences
Address513 Parnassus Avenue, HSE 1600
San Francisco CA 94143
Phone415-502-2637
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    Other Positions
    TitleChair, Obstetrics, Gynecology and Reproductive Sciences


    Collapse Biography 
    Collapse Education and Training
    Stanford UniversityM.D.1982School of Medicine

    Collapse Overview 
    Collapse Overview
    Dr. Giudice is a biochemist, gynecologist, and reproductive endocrinologist whose research focuses on environmental impacts on reproductive health, steroid hormone signaling in human endometrium, endometrial-placental interactions, endometrium as a mucosal tissue, and translational applications of human embryonic and endometrial stem cells. Her clinical interests are endometriosis, infertility, assisted reproduction, and implantation and ovulatory disorders. She is director of the Center for Research on Origins and Biological Consequences of Human Infertility and the UCSF Women's Reproductive Health Research Career Development Center.


    Collapse Research 
    Collapse Research Activities and Funding
    Integrative Analysis of Genomic, Epigenomic and Phenotypic Data for Disease Stratification of Endometriosis
    NIH/NICHD R01HD089511Sep 26, 2016 - Apr 30, 2021
    Role: Co-Principal Investigator
    Exploring HIV-Host Interactions in the Female Reproductive Tract
    NIH/NIAID P01AI083050Sep 1, 2009 - Aug 31, 2014
    Role: Co-Principal Investigator
    Origins and Biological Consequences of Human Infertility
    NIH/NICHD P50HD055764May 3, 2007 - Mar 31, 2017
    Role: Principal Investigator
    Origins and Biological Consequences of Human Infertility
    NIH/NICHD U54HD055764May 3, 2007 - Mar 31, 2017
    Role: Principal Investigator
    Summit on Environmental Challenges to Reproductive Health and Fertility
    NIH/NIEHS R13ES015427Sep 15, 2006 - Aug 31, 2007
    Role: Principal Investigator
    Mentoring &Interdisciplinary Research in Women's Health
    NIH/NICHD K12HD043452Sep 27, 2002 - Dec 31, 2008
    Role: Co-Principal Investigator
    Gordon Research Conference on Reproductive Tract Biology
    NIH/NICHD R13HD042663Jun 19, 2002 - May 31, 2003
    Role: Principal Investigator
    Federally Registered Human Embryonic Stem Cell Center
    NIH/NCRR R24RR017498May 1, 2002 - Jul 31, 2007
    Role: Principal Investigator
    Role of IGF-II in Human Trophoblast-Decidua Interactions
    NIH/NICHD U01HD042298Apr 1, 2002 - Mar 31, 2008
    Role: Principal Investigator
    HYPOXIA, IGFBP-1, AND HUMAN FETAL GROWTH
    NIH/NICHD R01HD036732Mar 1, 2000 - Aug 31, 2004
    Role: Principal Investigator
    Women's Reproductive Health Research
    NIH/NICHD K12HD001262Sep 30, 1998 - Jun 30, 2020
    Role: Co-Principal Investigator
    Gonadal and Endometrial Function in Human Reproduction
    NIH/NICHD U54HD031398Apr 7, 1997 - Mar 31, 2008
    Role: Co-Principal Investigator
    ROLE OF IGF IN HUMAN OVARY
    NIH/NICHD R01HD031579May 1, 1994 - Sep 30, 2008
    Role: Principal Investigator
    INSULIN-LIKE GROWTH FACTOR SYSTEM IN OVIDUCT
    NIH/NICHD R03HD028079May 1, 1991 - Apr 30, 1993
    Role: Principal Investigator
    IGF BINDING PROTEINS AND HUMAN ENDOMETRIUM
    NIH/NICHD R01HD025220Apr 1, 1990 - Jul 31, 2002
    Role: Principal Investigator
    GENE EXPRESSION IN ENDOMETRIUM
    NIH/NICHD R29HD025220Apr 1, 1990 - Mar 31, 1996
    Role: Principal Investigator
    General Clinical Research Center
    NIH M01RR000070Dec 1, 1978 - Nov 30, 2011
    Role: Co-Investigator

    Collapse ORNG Applications 
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    Collapse In The News
    Collapse Clinical Trials
    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Neidleman JA, Chen JC, Kohgadai N, Müller JA, Laustsen A, Thavachelvam K, Jang KS, Stürzel CM, Jones JJ, Ochsenbauer C, Chitre A, Somsouk M, Garcia MM, Smith JF, Greenblatt RM, Münch J, Jakobsen MR, Giudice L, Greene WC, Roan NR. Mucosal stromal fibroblasts markedly enhance HIV infection of CD4+ T cells. PLoS Pathog. 2017 Feb; 13(2):e1006163. PMID: 28207890.
      View in: PubMed
    2. Smith-McCune KK, Hilton JF, Shanmugasundaram U, Critchfield JW, Greenblatt RM, Seidman D, Averbach S, Giudice L, Shacklett BL. Effects of depot-medroxyprogesterone acetate on the immune microenvironment of the human cervix and endometrium: implications for HIV susceptibility. Mucosal Immunol. 2017 Jan 04. PMID: 28051087.
      View in: PubMed
    3. Johnson NP, Hummelshoj L, Adamson GD, Keckstein J, Taylor HS, Abrao MS, Bush D, Kiesel L, Tamimi R, Sharpe-Timms KL, Rombauts L, Giudice L. World Endometriosis Society consensus on the classification of endometriosis. Hum Reprod. 2016 Dec 05. PMID: 27920089.
      View in: PubMed
    4. Arora R, Fries A, Oelerich K, Marchuk K, Sabeur K, Giudice L, Laird DJ. Insights from imaging the implanting embryo and the uterine environment in three-dimensions. Development. 2016 Nov 11. PMID: 27836961.
      View in: PubMed
    5. Giudice L. Challenging dogma: the endometrium has a microbiome with functional consequences! Am J Obstet Gynecol. 2016 Oct 7. PMID: 27725136.
      View in: PubMed
    6. Giudice L. Environmental toxicants: hidden players on the reproductive stage. Fertil Steril. 2016 Sep 15; 106(4):791-4. PMID: 27545021.
      View in: PubMed
    7. Houshdaran S, Nezhat CR, Vo KC, Zelenko Z, Irwin JC, Giudice L. Aberrant Endometrial DNA Methylome and Associated Gene Expression in Women with Endometriosis. Biol Reprod. 2016 Nov; 95(5):93. PMID: 27535958.
      View in: PubMed
    8. Shanmugasundaram U, Hilton JF, Critchfield JW, Greenblatt RM, Giudice L, Averbach S, Seidman D, Shacklett BL, Smith-McCune K. Effects of the levonorgestrel-releasing intrauterine device on the immune microenvironment of the human cervix and endometrium. Am J Reprod Immunol. 2016 Aug; 76(2):137-48. PMID: 27401588.
      View in: PubMed
    9. Aghajanova L, Altmäe S, Kasvandik S, Salumets A, Stavreus-Evers A, Giudice L. Stanniocalcin-1 expression in normal human endometrium and dysregulation in endometriosis. Fertil Steril. 2016 Sep 1; 106(3):681-691.e1. PMID: 27322879; PMCID: PMC5010972 [Available on 09/01/17].
    10. Herndon CN, Aghajanova L, Balayan S, Erikson D, Barragan F, Goldfien G, Vo KC, Hawkins S, Giudice L. Global Transcriptome Abnormalities of the Eutopic Endometrium From Women With Adenomyosis. Reprod Sci. 2016 Oct; 23(10):1289-303. PMID: 27233751.
      View in: PubMed
    11. Sutton PM, Giudice L, Woodruff TJ. Moving from awareness to action on preventing patient exposure to toxic environmental chemicals. Am J Obstet Gynecol. 2016 May; 214(5):555-8. PMID: 27126615.
      View in: PubMed
    12. Barragan F, Irwin JC, Balayan S, Erikson DW, Chen JC, Houshdaran S, Piltonen TT, Spitzer TL, George A, Rabban JT, Nezhat C, Giudice L. Human Endometrial Fibroblasts Derived from Mesenchymal Progenitors Inherit Progesterone Resistance and Acquire an Inflammatory Phenotype in the Endometrial Niche in Endometriosis. Biol Reprod. 2016 May; 94(5):118. PMID: 27075616.
      View in: PubMed
    13. Chen JC, Hoffman JR, Arora R, Perrone LA, Gonzalez-Gomez CJ, Vo KC, Laird DJ, Irwin JC, Giudice L. Cryopreservation and recovery of human endometrial epithelial cells with high viability, purity, and functional fidelity. Fertil Steril. 2016 Feb; 105(2):501-510.e1. PMID: 26515378.
      View in: PubMed
    14. Di Renzo GC, Conry JA, Blake J, DeFrancesco MS, DeNicola N, Martin JN, McCue KA, Richmond D, Shah A, Sutton P, Woodruff TJ, van der Poel SZ, Giudice L. International Federation of Gynecology and Obstetrics opinion on reproductive health impacts of exposure to toxic environmental chemicals. Int J Gynaecol Obstet. 2015 Dec; 131(3):219-25. PMID: 26433469.
      View in: PubMed
    15. Vannuccini S, Clifton VL, Fraser IS, Taylor HS, Critchley H, Giudice L, Petraglia F. Infertility and reproductive disorders: impact of hormonal and inflammatory mechanisms on pregnancy outcome. Hum Reprod Update. 2016 Jan; 22(1):104-15. PMID: 26395640.
      View in: PubMed
    16. Bergman Å, Becher G, Blumberg B, Bjerregaard P, Bornman R, Brandt I, Casey SC, Frouin H, Giudice L, Heindel JJ, Iguchi T, Jobling S, Kidd KA, Kortenkamp A, Lind PM, Muir D, Ochieng R, Ropstad E, Ross PS, Skakkebaek NE, Toppari J, Vandenberg LN, Woodruff TJ, Zoeller RT. Manufacturing doubt about endocrine disrupter science - A rebuttal of industry-sponsored critical comments on the UNEP/WHO report "State of the Science of Endocrine Disrupting Chemicals 2012". Regul Toxicol Pharmacol. 2015 Dec; 73(3):1007-17. PMID: 26239693.
      View in: PubMed
    17. Smith-McCune K, Chen JC, Greenblatt RM, Shanmugasundaram U, Shacklett BL, Hilton JF, Johnson B, Irwin JC, Giudice L. Unexpected Inflammatory Effects of Intravaginal Gels (Universal Placebo Gel and Nonoxynol-9) on the Upper Female Reproductive Tract: A Randomized Crossover Study. PLoS One. 2015; 10(7):e0129769. PMID: 26177352; PMCID: PMC4503751.
    18. Fassbender A, Burney RO, O DF, D'Hooghe T, Giudice L. Update on Biomarkers for the Detection of Endometriosis. Biomed Res Int. 2015; 2015:130854. PMID: 26240814; PMCID: PMC4512573.
    19. Vercellini P, Giudice L, Evers JL, Abrao MS. Reducing low-value care in endometriosis between limited evidence and unresolved issues: a proposal. Hum Reprod. 2015 Sep; 30(9):1996-2004. PMID: 26141710.
      View in: PubMed
    20. Heard ME, Velarde MC, Giudice L, Simmen FA, Simmen RC. Krüppel-Like Factor 13 Deficiency in Uterine Endometrial Cells Contributes to Defective Steroid Hormone Receptor Signaling but Not Lesion Establishment in a Mouse Model of Endometriosis. Biol Reprod. 2015 Jun; 92(6):140. PMID: 25904015.
      View in: PubMed
    21. Piltonen TT, Chen JC, Khatun M, Kangasniemi M, Liakka A, Spitzer T, Tran N, Huddleston H, Irwin JC, Giudice L. Endometrial stromal fibroblasts from women with polycystic ovary syndrome have impaired progesterone-mediated decidualization, aberrant cytokine profiles and promote enhanced immune cell migration in vitro. Hum Reprod. 2015 May; 30(5):1203-15. PMID: 25750105; PMCID: PMC4400200 [Available on 05/01/16].
    22. Goldfien GA, Barragan F, Chen J, Takeda M, Irwin JC, Perry J, Greenblatt RM, Smith-McCune KK, Giudice L. Progestin-Containing Contraceptives Alter Expression of Host Defense-Related Genes of the Endometrium and Cervix. Reprod Sci. 2015 Jul; 22(7):814-28. PMID: 25634912; PMCID: PMC4565478 [Available on 07/01/16].
    23. Williams KE, Miroshnychenko O, Johansen EB, Niles RK, Sundaram R, Kannan K, Albertolle M, Zhou Y, Prasad N, Drake PM, Giudice L, Hall SC, Witkowska HE, Buck Louis GM, Fisher SJ. Urine, peritoneal fluid and omental fat proteomes of reproductive age women: Endometriosis-related changes and associations with endocrine disrupting chemicals. J Proteomics. 2015 Jan 15; 113:194-205. PMID: 25284053; PMCID: PMC4467531.
    24. Vitonis AF, Vincent K, Rahmioglu N, Fassbender A, Buck Louis GM, Hummelshoj L, Giudice L, Stratton P, Adamson GD, Becker CM, Zondervan KT, Missmer SA. World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project: II. Clinical and covariate phenotype data collection in endometriosis research. Fertil Steril. 2014 Nov; 102(5):1223-32. PMID: 25256930; PMCID: PMC4252538.
    25. Rahmioglu N, Fassbender A, Vitonis AF, Tworoger SS, Hummelshoj L, D'Hooghe TM, Adamson GD, Giudice L, Becker CM, Zondervan KT, Missmer SA. World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project: III. Fluid biospecimen collection, processing, and storage in endometriosis research. Fertil Steril. 2014 Nov; 102(5):1233-43. PMID: 25256929; PMCID: PMC4230639.
    26. Fassbender A, Rahmioglu N, Vitonis AF, Viganò P, Giudice L, D'Hooghe TM, Hummelshoj L, Adamson GD, Becker CM, Missmer SA, Zondervan KT. World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project: IV. Tissue collection, processing, and storage in endometriosis research. Fertil Steril. 2014 Nov; 102(5):1244-53. PMID: 25256928; PMCID: PMC4230778.
    27. Tamaresis JS, Irwin JC, Goldfien GA, Rabban JT, Burney RO, Nezhat C, DePaolo LV, Giudice L. Molecular classification of endometriosis and disease stage using high-dimensional genomic data. Endocrinology. 2014 Dec; 155(12):4986-99. PMID: 25243856; PMCID: PMC4239429.
    28. Houshdaran S, Zelenko Z, Irwin JC, Giudice L. Human endometrial DNA methylome is cycle-dependent and is associated with gene expression regulation. Mol Endocrinol. 2014 Jul; 28(7):1118-35. PMID: 24877562; PMCID: PMC4075160.
    29. Alvarez P, Giudice L, Levine JD. Impact of surgical excision of lesions on pain in a rat model of endometriosis. Eur J Pain. 2015 Jan; 19(1):103-10. PMID: 24824436; PMCID: PMC4231021 [Available on 01/01/16].
    30. Chen JC, Johnson BA, Erikson DW, Piltonen TT, Barragan F, Chu S, Kohgadai N, Irwin JC, Greene WC, Giudice L, Roan NR. Seminal plasma induces global transcriptomic changes associated with cell migration, proliferation and viability in endometrial epithelial cells and stromal fibroblasts. Hum Reprod. 2014 Jun; 29(6):1255-70. PMID: 24626806; PMCID: PMC4017943.
    31. Shanmugasundaram U, Critchfield JW, Pannell J, Perry J, Giudice L, Smith-McCune K, Greenblatt RM, Shacklett BL. Phenotype and functionality of CD4+ and CD8+ T cells in the upper reproductive tract of healthy premenopausal women. Am J Reprod Immunol. 2014 Feb; 71(2):95-108. PMID: 24313954; PMCID: PMC3947236.
    32. Alvarez P, Bogen O, Chen X, Giudice L, Levine JD. Ectopic endometrium-derived leptin produces estrogen-dependent chronic pain in a rat model of endometriosis. Neuroscience. 2014 Jan 31; 258:111-20. PMID: 24239717; PMCID: PMC3947893.
    33. Altmäe S, Esteban FJ, Stavreus-Evers A, Simón C, Giudice L, Lessey BA, Horcajadas JA, Macklon NS, D'Hooghe T, Campoy C, Fauser BC, Salamonsen LA, Salumets A. Guidelines for the design, analysis and interpretation of 'omics' data: focus on human endometrium. Hum Reprod Update. 2014 Jan-Feb; 20(1):12-28. PMID: 24082038; PMCID: PMC3845681.
    34. Bergman Å, Andersson AM, Becher G, van den Berg M, Blumberg B, Bjerregaard P, Bornehag CG, Bornman R, Brandt I, Brian JV, Casey SC, Fowler PA, Frouin H, Giudice L, Iguchi T, Hass U, Jobling S, Juul A, Kidd KA, Kortenkamp A, Lind M, Martin OV, Muir D, Ochieng R, Olea N, Norrgren L, Ropstad E, Ross PS, Rudén C, Scheringer M, Skakkebaek NE, Söder O, Sonnenschein C, Soto A, Swan S, Toppari J, Tyler CR, Vandenberg LN, Vinggaard AM, Wiberg K, Zoeller RT. Science and policy on endocrine disrupters must not be mixed: a reply to a "common sense" intervention by toxicology journal editors. Environ Health. 2013; 12:69. PMID: 23981490; PMCID: PMC3765603.
    35. Hess AP, Talbi S, Hamilton AE, Baston-Buest DM, Nyegaard M, Irwin JC, Barragan F, Kruessel JS, Germeyer A, Giudice L. The human oviduct transcriptome reveals an anti-inflammatory, anti-angiogenic, secretory and matrix-stable environment during embryo transit. Reprod Biomed Online. 2013 Oct; 27(4):423-35. PMID: 23953067; PMCID: PMC3950339.
    36. Chen JC, Erikson DW, Piltonen TT, Meyer MR, Barragan F, McIntire RH, Tamaresis JS, Vo KC, Giudice L, Irwin JC. Coculturing human endometrial epithelial cells and stromal fibroblasts alters cell-specific gene expression and cytokine production. Fertil Steril. 2013 Oct; 100(4):1132-43. PMID: 23849844; PMCID: PMC3820417.
    37. Piltonen TT, Chen J, Erikson DW, Spitzer TL, Barragan F, Rabban JT, Huddleston H, Irwin JC, Giudice L. Mesenchymal stem/progenitors and other endometrial cell types from women with polycystic ovary syndrome (PCOS) display inflammatory and oncogenic potential. J Clin Endocrinol Metab. 2013 Sep; 98(9):3765-75. PMID: 23824412; PMCID: PMC3763978.
    38. Hyman RW, Fukushima M, Jiang H, Fung E, Rand L, Johnson B, Vo KC, Caughey AB, Hilton JF, Davis RW, Giudice L. Diversity of the vaginal microbiome correlates with preterm birth. Reprod Sci. 2014 Jan; 21(1):32-40. PMID: 23715799; PMCID: PMC3857766.
    39. Fisher SJ, Giudice L. Retrospective. Robert G. Edwards (1925-2013). Science. 2013 May 17; 340(6134):825. PMID: 23687039.
      View in: PubMed
    40. Buck Louis GM, Peterson CM, Chen Z, Croughan M, Sundaram R, Stanford J, Varner MW, Kennedy A, Giudice L, Fujimoto VY, Sun L, Wang L, Guo Y, Kannan K. Bisphenol A and phthalates and endometriosis: the Endometriosis: Natural History, Diagnosis and Outcomes Study. Fertil Steril. 2013 Jul; 100(1):162-9.e1-2. PMID: 23579005; PMCID: PMC3700684.
    41. Afshar Y, Hastings J, Roqueiro D, Jeong JW, Giudice L, Fazleabas AT. Changes in eutopic endometrial gene expression during the progression of experimental endometriosis in the baboon, Papio anubis. Biol Reprod. 2013 Feb; 88(2):44. PMID: 23284138; PMCID: PMC3589234.
    42. Rogers PA, D'Hooghe TM, Fazleabas A, Giudice L, Montgomery GW, Petraglia F, Taylor RN. Defining future directions for endometriosis research: workshop report from the 2011 World Congress of Endometriosis In Montpellier, France. Reprod Sci. 2013 May; 20(5):483-99. PMID: 23427182; PMCID: PMC3635070.
    43. Louis GM, Peterson CM, Chen Z, Hediger ML, Croughan MS, Sundaram R, Stanford JB, Fujimoto VY, Varner MW, Giudice L, Kennedy A, Sun L, Wu Q, Kannan K. Perfluorochemicals and endometriosis: the ENDO study. Epidemiology. 2012 Nov; 23(6):799-805. PMID: 22992575; PMCID: PMC4122261.
    44. Meldrum DR, Chang RJ, Giudice L, Balasch J, Barbieri RL. Role of decreased androgens in the ovarian response to stimulation in older women. Fertil Steril. 2013 Jan; 99(1):5-11. PMID: 23122826.
      View in: PubMed
    45. Alvarez P, Chen X, Hendrich J, Irwin JC, Green PG, Giudice L, Levine JD. Ectopic uterine tissue as a chronic pain generator. Neuroscience. 2012 Dec 6; 225:269-82. PMID: 22922120; PMCID: PMC3479308.
    46. Burney RO, Giudice L. Pathogenesis and pathophysiology of endometriosis. Fertil Steril. 2012 Sep; 98(3):511-9. PMID: 22819144; PMCID: PMC3836682.
    47. Buck Louis GM, Chen Z, Peterson CM, Hediger ML, Croughan MS, Sundaram R, Stanford JB, Varner MW, Fujimoto VY, Giudice L, Trumble A, Parsons PJ, Kannan K. Persistent lipophilic environmental chemicals and endometriosis: the ENDO Study. Environ Health Perspect. 2012 Jun; 120(6):811-6. PMID: 22417635; PMCID: PMC3385438.
    48. Hyman RW, St Onge RP, Kim H, Tamaresis JS, Miranda M, Aparicio AM, Fukushima M, Pourmand N, Giudice L, Davis RW. Molecular probe technology detects bacteria without culture. BMC Microbiol. 2012; 12:29. PMID: 22404909; PMCID: PMC3316761.
    49. Sutton P, Woodruff TJ, Perron J, Stotland N, Conry JA, Miller MD, Giudice L. Toxic environmental chemicals: the role of reproductive health professionals in preventing harmful exposures. Am J Obstet Gynecol. 2012 Sep; 207(3):164-73. PMID: 22405527.
      View in: PubMed
    50. Spitzer TL, Rojas A, Zelenko Z, Aghajanova L, Erikson DW, Barragan F, Meyer M, Tamaresis JS, Hamilton AE, Irwin JC, Giudice L. Perivascular human endometrial mesenchymal stem cells express pathways relevant to self-renewal, lineage specification, and functional phenotype. Biol Reprod. 2012 Feb; 86(2):58. PMID: 22075475; PMCID: PMC3290674.
    51. Pabona JM, Simmen FA, Nikiforov MA, Zhuang D, Shankar K, Velarde MC, Zelenko Z, Giudice L, Simmen RC. Krüppel-like factor 9 and progesterone receptor coregulation of decidualizing endometrial stromal cells: implications for the pathogenesis of endometriosis. J Clin Endocrinol Metab. 2012 Mar; 97(3):E376-92. PMID: 22259059; PMCID: PMC3319212.
    52. Aghajanova L, Shen S, Rojas AM, Fisher SJ, Irwin JC, Giudice L. Comparative transcriptome analysis of human trophectoderm and embryonic stem cell-derived trophoblasts reveal key participants in early implantation. Biol Reprod. 2012 Jan; 86(1):1-21. PMID: 21865555.
      View in: PubMed
    53. Hyman RW, Herndon CN, Jiang H, Palm C, Fukushima M, Bernstein D, Vo KC, Zelenko Z, Davis RW, Giudice L. The dynamics of the vaginal microbiome during infertility therapy with in vitro fertilization-embryo transfer. J Assist Reprod Genet. 2012 Feb; 29(2):105-15. PMID: 22222853; PMCID: PMC3270134.
    54. Leach RE, Jessmon P, Coutifaris C, Kruger M, Myers ER, Ali-Fehmi R, Carson SA, Legro RS, Schlaff WD, Carr BR, Steinkampf MP, Silva S, Leppert PC, Giudice L, Diamond MP, Armant DR. High throughput, cell type-specific analysis of key proteins in human endometrial biopsies of women from fertile and infertile couples. Hum Reprod. 2012 Mar; 27(3):814-28. PMID: 22215622; PMCID: PMC3279126.
    55. Zelenko Z, Aghajanova L, Irwin JC, Giudice L. Nuclear receptor, coregulator signaling, and chromatin remodeling pathways suggest involvement of the epigenome in the steroid hormone response of endometrium and abnormalities in endometriosis. Reprod Sci. 2012 Feb; 19(2):152-62. PMID: 22138541; PMCID: PMC3343132.
    56. White WB, Grady D, Giudice L, Berry SM, Zborowski J, Snabes MC. A cardiovascular safety study of LibiGel (testosterone gel) in postmenopausal women with elevated cardiovascular risk and hypoactive sexual desire disorder. Am Heart J. 2012 Jan; 163(1):27-32. PMID: 22172433.
      View in: PubMed
    57. Fisher SJ, Giudice L. SGK1: a fine balancing act for human pregnancy. Nat Med. 2011; 17(11):1348-9. PMID: 22064410.
      View in: PubMed
    58. Buck Louis GM, Hediger ML, Peterson CM, Croughan M, Sundaram R, Stanford J, Chen Z, Fujimoto VY, Varner MW, Trumble A, Giudice L. Incidence of endometriosis by study population and diagnostic method: the ENDO study. Fertil Steril. 2011 Aug; 96(2):360-5. PMID: 21719000; PMCID: PMC3143230.
    59. Savaris RF, Groll JM, Young SL, DeMayo FJ, Jeong JW, Hamilton AE, Giudice L, Lessey BA. Progesterone resistance in PCOS endometrium: a microarray analysis in clomiphene citrate-treated and artificial menstrual cycles. J Clin Endocrinol Metab. 2011 Jun; 96(6):1737-46. PMID: 21411543; PMCID: PMC3100753.
    60. Sheldon E, Vo KC, McIntire RA, Aghajanova L, Zelenko Z, Irwin JC, Giudice L. Biobanking human endometrial tissue and blood specimens: standard operating procedure and importance to reproductive biology research and diagnostic development. Fertil Steril. 2011 May; 95(6):2120-2, 2122.e1-12. PMID: 21371706; PMCID: PMC3080464.
    61. Marchand M, Horcajadas JA, Esteban FJ, McElroy SL, Fisher SJ, Giudice L. Transcriptomic signature of trophoblast differentiation in a human embryonic stem cell model. Biol Reprod. 2011 Jun; 84(6):1258-71. PMID: 21368299.
      View in: PubMed
    62. Aghajanova L, Giudice L. Effect of bisphenol A on human endometrial stromal fibroblasts in vitro. Reprod Biomed Online. 2011 Mar; 22(3):249-56. PMID: 21273127; PMCID: PMC3836676.
    63. Sutton P, Giudice L, Woodruff TJ. Reproductive environmental health. Curr Opin Obstet Gynecol. 2010 Dec; 22(6):517-24. PMID: 20978443.
      View in: PubMed
    64. Aghajanova L, Giudice L. Molecular evidence for differences in endometrium in severe versus mild endometriosis. Reprod Sci. 2011 Mar; 18(3):229-51. PMID: 21063030; PMCID: PMC3118406.
    65. Aghajanova L, Tatsumi K, Horcajadas JA, Zamah AM, Esteban FJ, Herndon CN, Conti M, Giudice L. Unique transcriptome, pathways, and networks in the human endometrial fibroblast response to progesterone in endometriosis. Biol Reprod. 2011 Apr; 84(4):801-15. PMID: 20864642; PMCID: PMC3062042.
    66. Salamonsen LA, Giudice L. "The curse": a 21st century perspective of models of its molecular basis. Endocrinology. 2010 Sep; 151(9):4092-5. PMID: 20736404.
      View in: PubMed
    67. Giudice L. Clinical practice. Endometriosis. N Engl J Med. 2010 Jun 24; 362(25):2389-98. PMID: 20573927; PMCID: PMC3108065.
    68. Jacoby VL, Fujimoto VY, Giudice L, Kuppermann M, Washington AE. Racial and ethnic disparities in benign gynecologic conditions and associated surgeries. Am J Obstet Gynecol. 2010 Jun; 202(6):514-21. PMID: 20430357; PMCID: PMC4625911.
    69. Woodruff TJ, Schwartz J, Giudice L. Research agenda for environmental reproductive health in the 21st century. J Epidemiol Community Health. 2010 Apr; 64(4):307-10. PMID: 20348330.
      View in: PubMed
    70. Huddleston HG, Cedars MI, Sohn SH, Giudice L, Fujimoto VY. Racial and ethnic disparities in reproductive endocrinology and infertility. Am J Obstet Gynecol. 2010 May; 202(5):413-9. PMID: 20207341.
      View in: PubMed
    71. Lo B, Parham L, Cedars M, Fisher S, Gates E, Giudice L, Halme DG, Hershon W, Kriegstein A, Rao R, Roberts C, Wagner R. Research ethics. NIH guidelines for stem cell research and gamete donors. Science. 2010 Feb 19; 327(5968):962-3. PMID: 20167773; PMCID: PMC2892655.
    72. Aghajanova L, Horcajadas JA, Esteban FJ, Giudice L. The bone marrow-derived human mesenchymal stem cell: potential progenitor of the endometrial stromal fibroblast. Biol Reprod. 2010 Jun; 82(6):1076-87. PMID: 20147733; PMCID: PMC2874495.
    73. Nyegaard M, Overgaard MT, Su YQ, Hamilton AE, Kwintkiewicz J, Hsieh M, Nayak NR, Conti M, Conover CA, Giudice L. Lack of functional pregnancy-associated plasma protein-A (PAPPA) compromises mouse ovarian steroidogenesis and female fertility. Biol Reprod. 2010 Jun; 82(6):1129-38. PMID: 20130263; PMCID: PMC2874498.
    74. Aghajanova L, Velarde MC, Giudice L. Altered gene expression profiling in endometrium: evidence for progesterone resistance. Semin Reprod Med. 2010 Jan; 28(1):51-8. PMID: 20104428.
      View in: PubMed
    75. Aghajanova L, Horcajadas JA, Weeks JL, Esteban FJ, Nezhat CN, Conti M, Giudice L. The protein kinase A pathway-regulated transcriptome of endometrial stromal fibroblasts reveals compromised differentiation and persistent proliferative potential in endometriosis. Endocrinology. 2010 Mar; 151(3):1341-55. PMID: 20068008; PMCID: PMC2840687.
    76. Lo B, Parham L, Alvarez-Buylla A, Cedars M, Conklin B, Fisher S, Gates E, Giudice L, Halme DG, Hershon W, Kriegstein A, Kwok PY, Wagner R. Cloning mice and men: prohibiting the use of iPS cells for human reproductive cloning. Cell Stem Cell. 2010 Jan 8; 6(1):16-20. PMID: 20085739; PMCID: PMC4035242.
    77. Van Vaerenbergh I, McIntire R, Van Lommel L, Devroey P, Giudice L, Bourgain C. Gene expression during successful implantation in a natural cycle. Fertil Steril. 2010 Jan; 93(1):268.e15-8. PMID: 19880110; PMCID: PMC2812655.
    78. Kwintkiewicz J, Nishi Y, Yanase T, Giudice L. Peroxisome proliferator-activated receptor-gamma mediates bisphenol A inhibition of FSH-stimulated IGF-1, aromatase, and estradiol in human granulosa cells. Environ Health Perspect. 2010 Mar; 118(3):400-6. PMID: 20064783; PMCID: PMC2854770.
    79. Burney RO, Hamilton AE, Aghajanova L, Vo KC, Nezhat CN, Lessey BA, Giudice L. MicroRNA expression profiling of eutopic secretory endometrium in women with versus without endometriosis. Mol Hum Reprod. 2009 Oct; 15(10):625-31. PMID: 19692421; PMCID: PMC2744474.
    80. Velarde MC, Aghajanova L, Nezhat CR, Giudice L. Increased mitogen-activated protein kinase kinase/extracellularly regulated kinase activity in human endometrial stromal fibroblasts of women with endometriosis reduces 3',5'-cyclic adenosine 5'-monophosphate inhibition of cyclin D1. Endocrinology. 2009 Oct; 150(10):4701-12. PMID: 19589865; PMCID: PMC2754675.
    81. Pagidas K, Carson SA, McGovern PG, Barnhart HX, Myers ER, Legro RS, Diamond MP, Carr BR, Schlaff WD, Coutifaris C, Steinkampf MP, Cataldo NA, Nestler JE, Gosman G, Giudice L. Body mass index and intercourse compliance. Fertil Steril. 2010 Sep; 94(4):1447-50. PMID: 19540480; PMCID: PMC3708655.
    82. Pagidas K, Carson SA, McGovern PG, Barnhart HX, Myers ER, Legro RS, Diamond MP, Carr BR, Schlaff WD, Coutifaris C, Steinkampf MP, Cataldo NA, Nestler JE, Gosman G, Giudice L. Intercourse compliance, ovulation, and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome (PPCOS) Trial. Fertil Steril. 2010 Sep; 94(4):1444-6. PMID: 19540477; PMCID: PMC2891817.
    83. Rausch ME, Legro RS, Barnhart HX, Schlaff WD, Carr BR, Diamond MP, Carson SA, Steinkampf MP, McGovern PG, Cataldo NA, Gosman GG, Nestler JE, Giudice L, Leppert PC, Myers ER, Coutifaris C. Predictors of pregnancy in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2009 Sep; 94(9):3458-66. PMID: 19509098; PMCID: PMC2741722.
    84. Diamanti-Kandarakis E, Bourguignon JP, Giudice L, Hauser R, Prins GS, Soto AM, Zoeller RT, Gore AC. Endocrine-disrupting chemicals: an Endocrine Society scientific statement. Endocr Rev. 2009 Jun; 30(4):293-342. PMID: 19502515; PMCID: PMC2726844.
    85. Jeong JW, Lee HS, Lee KY, White LD, Broaddus RR, Zhang YW, Vande Woude GF, Giudice L, Young SL, Lessey BA, Tsai SY, Lydon JP, DeMayo FJ. Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease. Proc Natl Acad Sci U S A. 2009 May 26; 106(21):8677-82. PMID: 19439667; PMCID: PMC2681319.
    86. Robertson RP, Giudice L. Editorial: Update on stem cell research. Endocr Rev. 2009 May; 30(3):203. PMID: 19433633.
      View in: PubMed
    87. Aghajanova L, Velarde MC, Giudice L. The progesterone receptor coactivator Hic-5 is involved in the pathophysiology of endometriosis. Endocrinology. 2009 Aug; 150(8):3863-70. PMID: 19389829; PMCID: PMC2717860.
    88. Lo B, Parham L, Broom C, Cedars M, Gates E, Giudice L, Halme DG, Hershon W, Kriegstein A, Kwok PY, Oberman M, Roberts C, Wagner R. Importing human pluripotent stem cell lines derived at another institution: tailoring review to ethical concerns. Cell Stem Cell. 2009 Feb 6; 4(2):115-23. PMID: 19200800.
      View in: PubMed
    89. Kwintkiewicz J, Giudice L. The interplay of insulin-like growth factors, gonadotropins, and endocrine disruptors in ovarian follicular development and function. Semin Reprod Med. 2009 Jan; 27(1):43-51. PMID: 19197804.
      View in: PubMed
    90. Rogers PA, D'Hooghe TM, Fazleabas A, Gargett CE, Giudice L, Montgomery GW, Rombauts L, Salamonsen LA, Zondervan KT. Priorities for endometriosis research: recommendations from an international consensus workshop. Reprod Sci. 2009 Apr; 16(4):335-46. PMID: 19196878; PMCID: PMC3682634.
    91. Savaris RF, Giudice L. Genomics analysis: endometrium. Methods Mol Biol. 2009; 590:91-113. PMID: 19763499.
      View in: PubMed
    92. Conti M, Giudice L. From stem cells to germ cells and back again. Nat Med. 2008 Nov; 14(11):1188-90. PMID: 18989302.
      View in: PubMed
    93. Crain DA, Janssen SJ, Edwards TM, Heindel J, Ho SM, Hunt P, Iguchi T, Juul A, McLachlan JA, Schwartz J, Skakkebaek N, Soto AM, Swan S, Walker C, Woodruff TK, Woodruff TJ, Giudice L, Guillette LJ. Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing. Fertil Steril. 2008 Oct; 90(4):911-40. PMID: 18929049; PMCID: PMC4086418.
    94. Aghajanova L, Hamilton A, Kwintkiewicz J, Vo KC, Giudice L. Steroidogenic enzyme and key decidualization marker dysregulation in endometrial stromal cells from women with versus without endometriosis. Biol Reprod. 2009 Jan; 80(1):105-14. PMID: 18815356; PMCID: PMC2704986.
    95. Stillerman KP, Mattison DR, Giudice L, Woodruff TJ. Environmental exposures and adverse pregnancy outcomes: a review of the science. Reprod Sci. 2008 Sep; 15(7):631-50. PMID: 18836129.
      View in: PubMed
    96. Horcajadas JA, Mínguez P, Dopazo J, Esteban FJ, Domínguez F, Giudice L, Pellicer A, Simón C. Controlled ovarian stimulation induces a functional genomic delay of the endometrium with potential clinical implications. J Clin Endocrinol Metab. 2008 Nov; 93(11):4500-10. PMID: 18697870.
      View in: PubMed
    97. Fan X, Krieg S, Kuo CJ, Wiegand SJ, Rabinovitch M, Druzin ML, Brenner RM, Giudice L, Nayak NR. VEGF blockade inhibits angiogenesis and reepithelialization of endometrium. FASEB J. 2008 Oct; 22(10):3571-80. PMID: 18606863; PMCID: PMC2537439.
    98. Savaris RF, Hamilton AE, Lessey BA, Giudice L. Endometrial gene expression in early pregnancy: lessons from human ectopic pregnancy. Reprod Sci. 2008 Oct; 15(8):797-816. PMID: 18591649; PMCID: PMC2882188.
    99. Cataldo NA, Barnhart HX, Legro RS, Myers ER, Schlaff WD, Carr BR, Diamond MP, Carson SA, Steinkampf MP, Coutifaris C, McGovern PG, Gosman G, Nestler JE, Giudice L. Extended-release metformin does not reduce the clomiphene citrate dose required to induce ovulation in polycystic ovary syndrome. J Clin Endocrinol Metab. 2008 Aug; 93(8):3124-7. PMID: 18505764; PMCID: PMC2515084.
    100. McElroy SL, Kee K, Tran N, Menses J, Giudice L, Reijo Pera RA. Developmental competence of immature and failed/abnormally fertilized human oocytes in nuclear transfer. Reprod Biomed Online. 2008 May; 16(5):684-93. PMID: 18492373.
      View in: PubMed
    101. Macklon NS, van der Gaast MH, Hamilton A, Fauser BC, Giudice L. The impact of ovarian stimulation with recombinant FSH in combination with GnRH antagonist on the endometrial transcriptome in the window of implantation. Reprod Sci. 2008 Apr; 15(4):357-65. PMID: 18497344.
      View in: PubMed
    102. Woodruff TJ, Carlson A, Schwartz JM, Giudice L. Proceedings of the Summit on Environmental Challenges to Reproductive Health and Fertility: executive summary. Fertil Steril. 2008 Feb; 89(2):281-300. PMID: 18275883; PMCID: PMC2440710.
    103. Woodruff TJ, Carlson A, Schwartz JM, Giudice L. Proceedings of the Summit on Environmental Challenges to Reproductive Health and Fertility: executive summary. Fertil Steril. 2008 Feb; 89(2 Suppl):e1-e20. PMID: 18308046.
      View in: PubMed
    104. Dosiou C, Hamilton AE, Pang Y, Overgaard MT, Tulac S, Dong J, Thomas P, Giudice L. Expression of membrane progesterone receptors on human T lymphocytes and Jurkat cells and activation of G-proteins by progesterone. J Endocrinol. 2008 Jan; 196(1):67-77. PMID: 18180318.
      View in: PubMed
    105. McGovern PG, Carson SA, Barnhart HX, Myers ER, Legro RS, Diamond MP, Carr BR, Schlaff WD, Coutifaris C, Cataldo NA, Steinkampf MP, Nestler JE, Gosman G, Leppert PC, Giudice L. Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial. Fertil Steril. 2008 Oct; 90(4):1283-6. PMID: 18082737; PMCID: PMC2570771.
    106. Legro RS, Barnhart HX, Schlaff WD, Carr BR, Diamond MP, Carson SA, Steinkampf MP, Coutifaris C, McGovern PG, Cataldo NA, Gosman GG, Nestler JE, Giudice L, Ewens KG, Spielman RS, Leppert PC, Myers ER. Ovulatory response to treatment of polycystic ovary syndrome is associated with a polymorphism in the STK11 gene. J Clin Endocrinol Metab. 2008 Mar; 93(3):792-800. PMID: 18000088; PMCID: PMC2266955.
    107. Savaris RF, Giudice L. The influence of hydrosalpinx on markers of endometrial receptivity. Semin Reprod Med. 2007 Nov; 25(6):476-82. PMID: 17960532.
      View in: PubMed
    108. Aghajanova L, Hamilton AE, Giudice L. Uterine receptivity to human embryonic implantation: histology, biomarkers, and transcriptomics. Semin Cell Dev Biol. 2008 Apr; 19(2):204-11. PMID: 18035563; PMCID: PMC2829661.
    109. Burney RO, Talbi S, Hamilton AE, Vo KC, Nyegaard M, Nezhat CR, Lessey BA, Giudice L. Gene expression analysis of endometrium reveals progesterone resistance and candidate susceptibility genes in women with endometriosis. Endocrinology. 2007 Aug; 148(8):3814-26. PMID: 17510236.
      View in: PubMed
    110. Legro RS, Barnhart HX, Schlaff WD, Carr BR, Diamond MP, Carson SA, Steinkampf MP, Coutifaris C, McGovern PG, Cataldo NA, Gosman GG, Nestler JE, Giudice L, Leppert PC, Myers ER. Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome. N Engl J Med. 2007 Feb 8; 356(6):551-66. PMID: 17287476.
      View in: PubMed
    111. McGovern PG, Legro RS, Myers ER, Barnhart HX, Carson SA, Diamond MP, Carr BR, Schlaff WD, Coutifaris C, Steinkampf MP, Nestler JE, Gosman G, Leppert PC, Giudice L. Utility of screening for other causes of infertility in women with "known" polycystic ovary syndrome. Fertil Steril. 2007 Feb; 87(2):442-4. PMID: 17141768; PMCID: PMC1813322.
    112. Hess AP, Hamilton AE, Talbi S, Dosiou C, Nyegaard M, Nayak N, Genbecev-Krtolica O, Mavrogianis P, Ferrer K, Kruessel J, Fazleabas AT, Fisher SJ, Giudice L. Decidual stromal cell response to paracrine signals from the trophoblast: amplification of immune and angiogenic modulators. Biol Reprod. 2007 Jan; 76(1):102-17. PMID: 17021345.
      View in: PubMed
    113. Red-Horse K, Rivera J, Schanz A, Zhou Y, Winn V, Kapidzic M, Maltepe E, Okazaki K, Kochman R, Vo KC, Giudice L, Erlebacher A, McCune JM, Stoddart CA, Fisher SJ. Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation. J Clin Invest. 2006 Oct; 116(10):2643-52. PMID: 16998586; PMCID: PMC1570373.
    114. Su YQ, Nyegaard M, Overgaard MT, Qiao J, Giudice L. Participation of mitogen-activated protein kinase in luteinizing hormone-induced differential regulation of steroidogenesis and steroidogenic gene expression in mural and cumulus granulosa cells of mouse preovulatory follicles. Biol Reprod. 2006 Dec; 75(6):859-67. PMID: 16943367.
      View in: PubMed
    115. Giudice L. Infertility and the environment: the medical context. Semin Reprod Med. 2006 Jul; 24(3):129-33. PMID: 16804810.
      View in: PubMed
    116. Legro RS, Azziz R, Giudice L. A twenty-first century research agenda for polycystic ovary syndrome. Best Pract Res Clin Endocrinol Metab. 2006 Jun; 20(2):331-6. PMID: 16772161.
      View in: PubMed
    117. Giudice L. Endometrium in PCOS: Implantation and predisposition to endocrine CA. Best Pract Res Clin Endocrinol Metab. 2006 Jun; 20(2):235-44. PMID: 16772154.
      View in: PubMed
    118. Tulac S, Overgaard MT, Hamilton AE, Jumbe NL, Suchanek E, Giudice L. Dickkopf-1, an inhibitor of Wnt signaling, is regulated by progesterone in human endometrial stromal cells. J Clin Endocrinol Metab. 2006 Apr; 91(4):1453-61. PMID: 16449346.
      View in: PubMed
    119. Macklon NS, Stouffer RL, Giudice L, Fauser BC. The science behind 25 years of ovarian stimulation for in vitro fertilization. Endocr Rev. 2006 Apr; 27(2):170-207. PMID: 16434510.
      View in: PubMed
    120. Nayak NR, Kuo CJ, Desai TA, Wiegand SJ, Lasley BL, Giudice L, Brenner RM. Expression, localization and hormonal control of angiopoietin-1 in the rhesus macaque endometrium: potential role in spiral artery growth. Mol Hum Reprod. 2005 Nov; 11(11):791-9. PMID: 16390855.
      View in: PubMed
    121. Red-Horse K, Rivera J, Schanz A, Zhou Y, Winn V, Kapidzic M, Maltepe E, Okazaki K, Kochman R, Vo KC, Giudice L, Erlebacher A, McCune JM, Stoddart CA, Fisher SJ. Literature watch. Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation. Lymphat Res Biol. 2006; 4(4):229-42. PMID: 17394406.
      View in: PubMed
    122. Giudice L. Application of functional genomics to primate endometrium: insights into biological processes. Reprod Biol Endocrinol. 2006; 4 Suppl 1:S4. PMID: 17118168; PMCID: PMC1775064.
    123. Hess AP, Hirchenhain J, Schanz A, Talbi S, Hamilton AE, Giudice L, Krüssel JS. Angiopoietin-1 and -2 mRNA and protein expression in mouse preimplantation embryos and uteri suggests a role in angiogenesis during implantation. Reprod Fertil Dev. 2006; 18(5):509-16. PMID: 16836957.
      View in: PubMed
    124. Nezhat C, Littman ED, Lathi RB, Berker B, Westphal LM, Giudice L, Milki AA. The dilemma of endometriosis: is consensus possible with an enigma? Fertil Steril. 2005 Dec; 84(6):1587-8. PMID: 16359950.
      View in: PubMed
    125. Littman E, Giudice L, Lathi R, Berker B, Milki A, Nezhat C. Role of laparoscopic treatment of endometriosis in patients with failed in vitro fertilization cycles. Fertil Steril. 2005 Dec; 84(6):1574-8. PMID: 16359945.
      View in: PubMed
    126. Talbi S, Hamilton AE, Vo KC, Tulac S, Overgaard MT, Dosiou C, Le Shay N, Nezhat CN, Kempson R, Lessey BA, Nayak NR, Giudice L. Molecular phenotyping of human endometrium distinguishes menstrual cycle phases and underlying biological processes in normo-ovulatory women. Endocrinology. 2006 Mar; 147(3):1097-121. PMID: 16306079.
      View in: PubMed
    127. Li T, Vu TH, Ulaner GA, Littman E, Ling JQ, Chen HL, Hu JF, Behr B, Giudice L, Hoffman AR. IVF results in de novo DNA methylation and histone methylation at an Igf2-H19 imprinting epigenetic switch. Mol Hum Reprod. 2005 Sep; 11(9):631-40. PMID: 16219628.
      View in: PubMed
    128. Cataldo NA, Abbasi F, McLaughlin TL, Basina M, Fechner PY, Giudice L, Reaven GM. Metabolic and ovarian effects of rosiglitazone treatment for 12 weeks in insulin-resistant women with polycystic ovary syndrome. Hum Reprod. 2006 Jan; 21(1):109-20. PMID: 16155076.
      View in: PubMed
    129. Tang M, Mikhailik A, Pauli I, Giudice L, Fazelabas AT, Tulac S, Carson DD, Kaufman DG, Barbier C, Creemers JW, Tabibzadeh S. Decidual differentiation of stromal cells promotes Proprotein Convertase 5/6 expression and lefty processing. Endocrinology. 2005 Dec; 146(12):5313-20. PMID: 16141390.
      View in: PubMed
    130. Hyman RW, Fukushima M, Diamond L, Kumm J, Giudice L, Davis RW. Microbes on the human vaginal epithelium. Proc Natl Acad Sci U S A. 2005 May 31; 102(22):7952-7. PMID: 15911771; PMCID: PMC1142396.
    131. Dosiou C, Giudice L. Natural killer cells in pregnancy and recurrent pregnancy loss: endocrine and immunologic perspectives. Endocr Rev. 2005 Feb; 26(1):44-62. PMID: 15689572.
      View in: PubMed
    132. Glerup S, Boldt HB, Overgaard MT, Sottrup-Jensen L, Giudice L, Oxvig C. Proteinase inhibition by proform of eosinophil major basic protein (pro-MBP) is a multistep process of intra- and intermolecular disulfide rearrangements. J Biol Chem. 2005 Mar 18; 280(11):9823-32. PMID: 15647258.
      View in: PubMed
    133. Lathi RB, Hess AP, Tulac S, Nayak NR, Conti M, Giudice L. Dose-dependent insulin regulation of insulin-like growth factor binding protein-1 in human endometrial stromal cells is mediated by distinct signaling pathways. J Clin Endocrinol Metab. 2005 Mar; 90(3):1599-606. PMID: 15613433.
      View in: PubMed
    134. Germeyer A, Hamilton AE, Laughlin LS, Lasley BL, Brenner RM, Giudice L, Nayak NR. Cellular expression and hormonal regulation of neuropilin-1 and -2 messenger ribonucleic Acid in the human and rhesus macaque endometrium. J Clin Endocrinol Metab. 2005 Mar; 90(3):1783-90. PMID: 15613413.
      View in: PubMed
    135. Giudice L, Kao LC. Endometriosis. Lancet. 2004 Nov 13-19; 364(9447):1789-99. PMID: 15541453.
      View in: PubMed
    136. McGovern PG, Myers ER, Silva S, Coutifaris C, Carson SA, Legro RS, Schlaff WD, Carr BR, Steinkampf MP, Giudice L, Leppert PC, Diamond MP. Absence of secretory endometrium after false-positive home urine luteinizing hormone testing. Fertil Steril. 2004 Nov; 82(5):1273-7. PMID: 15533341.
      View in: PubMed
    137. Lobo SC, Huang ST, Germeyer A, Dosiou C, Vo KC, Tulac S, Nayak NR, Giudice L. The immune environment in human endometrium during the window of implantation. Am J Reprod Immunol. 2004 Oct; 52(4):244-51. PMID: 15494045.
      View in: PubMed
    138. Tulac S, Dosiou C, Suchanek E, Giudice L. Silencing lamin A/C in human endometrial stromal cells: a model to investigate endometrial gene function and regulation. Mol Hum Reprod. 2004 Oct; 10(10):705-11. PMID: 15347737.
      View in: PubMed
    139. Huang ST, Vo KC, Lyell DJ, Faessen GH, Tulac S, Tibshirani R, Giaccia AJ, Giudice L. Developmental response to hypoxia. FASEB J. 2004 Sep; 18(12):1348-65. PMID: 15333578.
      View in: PubMed
    140. Boldt HB, Kjaer-Sorensen K, Overgaard MT, Weyer K, Poulsen CB, Sottrup-Jensen L, Conover CA, Giudice L, Oxvig C. The Lin12-notch repeats of pregnancy-associated plasma protein-A bind calcium and determine its proteolytic specificity. J Biol Chem. 2004 Sep 10; 279(37):38525-31. PMID: 15262980.
      View in: PubMed
    141. Dosiou C, Lathi RB, Tulac S, Huang ST, Giudice L. Interferon-related and other immune genes are downregulated in peripheral blood leukocytes in the luteal phase of the menstrual cycle. J Clin Endocrinol Metab. 2004 May; 89(5):2501-4. PMID: 15126584.
      View in: PubMed
    142. Weyer K, Overgaard MT, Laursen LS, Nielsen CG, Schmitz A, Christiansen M, Sottrup-Jensen L, Giudice L, Oxvig C. Cell surface adhesion of pregnancy-associated plasma protein-A is mediated by four clusters of basic residues located in its third and fourth CCP module. Eur J Biochem. 2004 Apr; 271(8):1525-35. PMID: 15066178.
      View in: PubMed
    143. Tierney EP, Giudice L. Role of activin A as a mediator of in vitro endometrial stromal cell decidualization via the cyclic adenosine monophosphate pathway. Fertil Steril. 2004 Mar; 81 Suppl 1:899-903. PMID: 15019827.
      View in: PubMed
    144. Overgaard MT, Glerup S, Boldt HB, Rodacker V, Olsen IM, Christiansen M, Sottrup-Jensen L, Giudice L, Oxvig C. Inhibition of proteolysis by the proform of eosinophil major basic protein (proMBP) requires covalent binding to its target proteinase. FEBS Lett. 2004 Feb 27; 560(1-3):147-52. PMID: 14988014.
      View in: PubMed
    145. Giudice L. Microarray expression profiling reveals candidate genes for human uterine receptivity. Am J Pharmacogenomics. 2004; 4(5):299-312. PMID: 15462608.
      View in: PubMed
    146. Tierney EP, Tulac S, Huang ST, Giudice L. Activation of the protein kinase A pathway in human endometrial stromal cells reveals sequential categorical gene regulation. Physiol Genomics. 2003 Dec 16; 16(1):47-66. PMID: 14532334.
      View in: PubMed
    147. Tulac S, Nayak NR, Kao LC, Van Waes M, Huang J, Lobo S, Germeyer A, Lessey BA, Taylor RN, Suchanek E, Giudice L. Identification, characterization, and regulation of the canonical Wnt signaling pathway in human endometrium. J Clin Endocrinol Metab. 2003 Aug; 88(8):3860-6. PMID: 12915680.
      View in: PubMed
    148. Milki AA, Jun SH, Hinckley MD, Westphal LW, Giudice L, Behr B. Comparison of the sex ratio with blastocyst transfer and cleavage stage transfer. J Assist Reprod Genet. 2003 Aug; 20(8):323-6. PMID: 12948095; PMCID: PMC3455273.
    149. Kao LC, Germeyer A, Tulac S, Lobo S, Yang JP, Taylor RN, Osteen K, Lessey BA, Giudice L. Expression profiling of endometrium from women with endometriosis reveals candidate genes for disease-based implantation failure and infertility. Endocrinology. 2003 Jul; 144(7):2870-81. PMID: 12810542.
      View in: PubMed
    150. Lyell DJ, Lambert-Messerlian GM, Giudice L. Prenatal screening, epidemiology, diagnosis, and management of preeclampsia. Clin Lab Med. 2003 Jun; 23(2):413-42. PMID: 12848452.
      View in: PubMed
    151. Giudice L. Elucidating endometrial function in the post-genomic era. Hum Reprod Update. 2003 May-Jun; 9(3):223-35. PMID: 12859044.
      View in: PubMed
    152. Giudice L. Genomics' role in understanding the pathogenesis of endometriosis. Semin Reprod Med. 2003 May; 21(2):119-24. PMID: 12917781.
      View in: PubMed
    153. Nayak NR, Giudice L. Comparative biology of the IGF system in endometrium, decidua, and placenta, and clinical implications for foetal growth and implantation disorders. Placenta. 2003 Apr; 24(4):281-96. PMID: 14626217.
      View in: PubMed
    154. Milki AA, Jun SH, Hinckley MD, Behr B, Giudice L, Westphal LM. Incidence of monozygotic twinning with blastocyst transfer compared to cleavage-stage transfer. Fertil Steril. 2003 Mar; 79(3):503-6. PMID: 12620430.
      View in: PubMed
    155. Verhaeghe J, Van Herck E, Billen J, Moerman P, Van Assche FA, Giudice L. Regulation of insulin-like growth factor-I and insulin-like growth factor binding protein-1 concentrations in preterm fetuses. Am J Obstet Gynecol. 2003 Feb; 188(2):485-91. PMID: 12592260.
      View in: PubMed
    156. Morrell MJ, Giudice L, Flynn KL, Seale CG, Paulson AJ, Doñe S, Flaster E, Ferin M, Sauer MV. Predictors of ovulatory failure in women with epilepsy. Ann Neurol. 2002 Dec; 52(6):704-11. PMID: 12447923.
      View in: PubMed
    157. Sun IY, Overgaard MT, Oxvig C, Giudice L. Pregnancy-associated plasma protein A proteolytic activity is associated with the human placental trophoblast cell membrane. J Clin Endocrinol Metab. 2002 Nov; 87(11):5235-40. PMID: 12414897.
      View in: PubMed
    158. Laursen LS, Overgaard MT, Weyer K, Boldt HB, Ebbesen P, Christiansen M, Sottrup-Jensen L, Giudice L, Oxvig C. Cell surface targeting of pregnancy-associated plasma protein A proteolytic activity. Reversible adhesion is mediated by two neighboring short consensus repeats. J Biol Chem. 2002 Dec 6; 277(49):47225-34. PMID: 12370176.
      View in: PubMed
    159. Laursen LS, Overgaard MT, Nielsen CG, Boldt HB, Hopmann KH, Conover CA, Sottrup-Jensen L, Giudice L, Oxvig C. Substrate specificity of the metalloproteinase pregnancy-associated plasma protein-A (PAPP-A) assessed by mutagenesis and analysis of synthetic peptides: substrate residues distant from the scissile bond are critical for proteolysis. Biochem J. 2002 Oct 1; 367(Pt 1):31-40. PMID: 12241545; PMCID: PMC1222882.
    160. Taylor RN, Lundeen SG, Giudice L. Emerging role of genomics in endometriosis research. Fertil Steril. 2002 Oct; 78(4):694-8. PMID: 12372442.
      View in: PubMed
    161. Giudice L. Maternal-fetal conflict--lessons from a transgene. J Clin Invest. 2002 Aug; 110(3):307-9. PMID: 12163449; PMCID: PMC151099.
    162. Kao LC, Tulac S, Lobo S, Imani B, Yang JP, Germeyer A, Osteen K, Taylor RN, Lessey BA, Giudice L. Global gene profiling in human endometrium during the window of implantation. Endocrinology. 2002 Jun; 143(6):2119-38. PMID: 12021176.
      View in: PubMed
    163. Giudice L, Conover CA, Bale L, Faessen GH, Ilg K, Sun I, Imani B, Suen LF, Irwin JC, Christiansen M, Overgaard MT, Oxvig C. Identification and regulation of the IGFBP-4 protease and its physiological inhibitor in human trophoblasts and endometrial stroma: evidence for paracrine regulation of IGF-II bioavailability in the placental bed during human implantation. J Clin Endocrinol Metab. 2002 May; 87(5):2359-66. PMID: 11994388.
      View in: PubMed
    164. Søe R, Overgaard MT, Thomsen AR, Laursen LS, Olsen IM, Sottrup-Jensen L, Haaning J, Giudice L, Conover CA, Oxvig C. Expression of recombinant murine pregnancy-associated plasma protein-A (PAPP-A) and a novel variant (PAPP-Ai) with differential proteolytic activity. Eur J Biochem. 2002 Apr; 269(8):2247-56. PMID: 11985604.
      View in: PubMed
    165. Bhatia S, Faessen GH, Carland G, Balise RL, Gargosky SE, Druzin M, El-Sayed Y, Wilson DM, Giudice L. A longitudinal analysis of maternal serum insulin-like growth factor I (IGF-I) and total and nonphosphorylated IGF-binding protein-1 in human pregnancies complicated by intrauterine growth restriction. J Clin Endocrinol Metab. 2002 Apr; 87(4):1864-70. PMID: 11932331.
      View in: PubMed
    166. Giudice L, Telles TL, Lobo S, Kao L. The molecular basis for implantation failure in endometriosis: on the road to discovery. Ann N Y Acad Sci. 2002 Mar; 955:252-64; discussion 293-5, 396-406. PMID: 11949953.
      View in: PubMed
    167. Imani B, Eijkemans MJ, Faessen GH, Bouchard P, Giudice L, Fauser BC. Prediction of the individual follicle-stimulating hormone threshold for gonadotropin induction of ovulation in normogonadotropic anovulatory infertility: an approach to increase safety and efficiency. Fertil Steril. 2002 Jan; 77(1):83-90. PMID: 11779595.
      View in: PubMed
    168. Verhaeghe J, Billen J, Giudice L. Insulin-like growth factor-binding protein-1 in umbilical artery and vein of term fetuses with signs suggestive of distress during labor. J Endocrinol. 2001 Sep; 170(3):585-90. PMID: 11524238.
      View in: PubMed
    169. Laursen LS, Overgaard MT, Søe R, Boldt HB, Sottrup-Jensen L, Giudice L, Conover CA, Oxvig C. Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: implications for the mechanism of IGFBP-4 proteolysis by PAPP-A. FEBS Lett. 2001 Aug 24; 504(1-2):36-40. PMID: 11522292.
      View in: PubMed
    170. Rivera GM, Chandrasekher YA, Evans AC, Giudice L, Fortune JE. A potential role for insulin-like growth factor binding protein-4 proteolysis in the establishment of ovarian follicular dominance in cattle. Biol Reprod. 2001 Jul; 65(1):102-11. PMID: 11420229.
      View in: PubMed
    171. Popovici RM, Lu M, Bhatia S, Faessen GH, Giaccia AJ, Giudice L. Hypoxia regulates insulin-like growth factor-binding protein 1 in human fetal hepatocytes in primary culture: suggestive molecular mechanisms for in utero fetal growth restriction caused by uteroplacental insufficiency. J Clin Endocrinol Metab. 2001 Jun; 86(6):2653-9. PMID: 11397868.
      View in: PubMed
    172. Irwin JC, Suen LF, Faessen GH, Popovici RM, Giudice L. Insulin-like growth factor (IGF)-II inhibition of endometrial stromal cell tissue inhibitor of metalloproteinase-3 and IGF-binding protein-1 suggests paracrine interactions at the decidua:trophoblast interface during human implantation. J Clin Endocrinol Metab. 2001 May; 86(5):2060-4. PMID: 11344207.
      View in: PubMed
    173. Conover CA, Faessen GF, Ilg KE, Chandrasekher YA, Christiansen M, Overgaard MT, Oxvig C, Giudice L. Pregnancy-associated plasma protein-a is the insulin-like growth factor binding protein-4 protease secreted by human ovarian granulosa cells and is a marker of dominant follicle selection and the corpus luteum. Endocrinology. 2001 May; 142(5):2155. PMID: 11316785.
      View in: PubMed
    174. Ulaner GA, Hu JF, Vu TH, Giudice L, Hoffman AR. Tissue-specific alternate splicing of human telomerase reverse transcriptase (hTERT) influences telomere lengths during human development. Int J Cancer. 2001 Mar 1; 91(5):644-9. PMID: 11267974.
      View in: PubMed
    175. Paulson RJ, Ory SJ, Giudice L, Schlaff WD, Santoro NF, Coddington CC. Multiple pregnancies: what action should we take? Fertil Steril. 2001 Jan; 75(1):14-5; discussion 16-7. PMID: 11163807.
      View in: PubMed
    176. Giudice L. Insulin-like growth factor family in Graafian follicle development and function. J Soc Gynecol Investig. 2001 Jan-Feb; 8(1 Suppl Proceedings):S26-9. PMID: 11223367.
      View in: PubMed
    177. Klein NA, Battaglia DE, Woodruff TK, Padmanabhan V, Giudice L, Bremner WJ, Soules MR. Ovarian follicular concentrations of activin, follistatin, inhibin, insulin-like growth factor I (IGF-I), IGF-II, IGF-binding protein-2 (IGFBP-2), IGFBP-3, and vascular endothelial growth factor in spontaneous menstrual cycles of normal women of advanced reproductive age. J Clin Endocrinol Metab. 2000 Dec; 85(12):4520-5. PMID: 11134102.
      View in: PubMed
    178. Sugawara J, Tazuke SI, Suen LF, Powell DR, Kaper F, Giaccia AJ, Giudice L. Regulation of insulin-like growth factor-binding protein 1 by hypoxia and 3',5'-cyclic adenosine monophosphate is additive in HepG2 cells. J Clin Endocrinol Metab. 2000 Oct; 85(10):3821-7. PMID: 11061545.
      View in: PubMed
    179. Popovici RM, Kao LC, Giudice L. Discovery of new inducible genes in in vitro decidualized human endometrial stromal cells using microarray technology. Endocrinology. 2000 Sep; 141(9):3510-3. PMID: 10965925.
      View in: PubMed
    180. Sugawara J, Suh DS, Faessen GH, Suen LF, Shibata T, Kaper F, Giaccia AJ, Giudice L. Regulation of insulin-like growth factor-binding protein-1 by nitric oxide under hypoxic conditions. J Clin Endocrinol Metab. 2000 Aug; 85(8):2714-21. PMID: 10946870.
      View in: PubMed
    181. Imani B, Eijkemans MJ, de Jong FH, Payne NN, Bouchard P, Giudice L, Fauser BC. Free androgen index and leptin are the most prominent endocrine predictors of ovarian response during clomiphene citrate induction of ovulation in normogonadotropic oligoamenorrheic infertility. J Clin Endocrinol Metab. 2000 Feb; 85(2):676-82. PMID: 10690875.
      View in: PubMed
    182. Ulaner GA, Hu JF, Vu TH, Oruganti H, Giudice L, Hoffman AR. Regulation of telomerase by alternate splicing of human telomerase reverse transcriptase (hTERT) in normal and neoplastic ovary, endometrium and myometrium. Int J Cancer. 2000 Feb 1; 85(3):330-5. PMID: 10652422.
      View in: PubMed
    183. Irwin JC, Suen LF, Cheng BH, Martin R, Cannon P, Deal CL, Giudice L. Human placental trophoblasts secrete a disintegrin metalloproteinase very similar to the insulin-like growth factor binding protein-3 protease in human pregnancy serum. Endocrinology. 2000 Feb; 141(2):666-74. PMID: 10650948.
      View in: PubMed
    184. Irwin JC, Suen LF, Martina NA, Mark SP, Giudice L. Role of the IGF system in trophoblast invasion and pre-eclampsia. Hum Reprod. 1999 Dec; 14 Suppl 2:90-6. PMID: 10690804.
      View in: PubMed
    185. Conover CA, Oxvig C, Overgaard MT, Christiansen M, Giudice L. Evidence that the insulin-like growth factor binding protein-4 protease in human ovarian follicular fluid is pregnancy associated plasma protein-A. J Clin Endocrinol Metab. 1999 Dec; 84(12):4742-5. PMID: 10599745.
      View in: PubMed
    186. Giudice L. Potential biochemical markers of uterine receptivity. Hum Reprod. 1999 Dec; 14 Suppl 2:3-16. PMID: 10690796.
      View in: PubMed
    187. Thierry van Dessel HJ, Lee PD, Faessen G, Fauser BC, Giudice L. Elevated serum levels of free insulin-like growth factor I in polycystic ovary syndrome. J Clin Endocrinol Metab. 1999 Sep; 84(9):3030-5. PMID: 10487660.
      View in: PubMed
    188. Poretsky L, Cataldo NA, Rosenwaks Z, Giudice L. The insulin-related ovarian regulatory system in health and disease. Endocr Rev. 1999 Aug; 20(4):535-82. PMID: 10453357.
      View in: PubMed
    189. Popovici RM, Irwin JC, Giaccia AJ, Giudice L. Hypoxia and cAMP stimulate vascular endothelial growth factor (VEGF) in human endometrial stromal cells: potential relevance to menstruation and endometrial regeneration. J Clin Endocrinol Metab. 1999 Jun; 84(6):2245-8. PMID: 10372740.
      View in: PubMed
    190. Giudice L. Growth factor action on ovarian function in polycystic ovary syndrome. Endocrinol Metab Clin North Am. 1999 Jun; 28(2):325-39, vi. PMID: 10352921.
      View in: PubMed
    191. Yuan W, Giudice L. Insulin-like growth factor-II mediates the steroidogenic and growth promoting actions of follicle stimulating hormone on human ovarian pre-antral follicles cultured in vitro. J Clin Endocrinol Metab. 1999 Apr; 84(4):1479-82. PMID: 10199799.
      View in: PubMed
    192. Giudice L. Genes associated with embryonic attachment and implantation and the role of progesterone. J Reprod Med. 1999 Feb; 44(2 Suppl):165-71. PMID: 11392027.
      View in: PubMed
    193. Giudice L, Irwin JC. Roles of the insulinlike growth factor family in nonpregnant human endometrium and at the decidual: trophoblast interface. Semin Reprod Endocrinol. 1999; 17(1):13-21. PMID: 10406071.
      View in: PubMed
    194. Chen BH, Giudice L. Dysfunctional uterine bleeding. West J Med. 1998 Nov; 169(5):280-4. PMID: 9830356; PMCID: PMC1305317.
    195. Ulaner GA, Hu JF, Vu TH, Giudice L, Hoffman AR. Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts. Cancer Res. 1998 Sep 15; 58(18):4168-72. PMID: 9751630.
      View in: PubMed
    196. Yap OW, Chandrasekher YA, Giudice L. Growth factor regulation of insulin-like growth factor binding protein secretion by cultured human granulosa-luteal cells. Fertil Steril. 1998 Sep; 70(3):535-40. PMID: 9757886.
      View in: PubMed
    197. Tazuke SI, Mazure NM, Sugawara J, Carland G, Faessen GH, Suen LF, Irwin JC, Powell DR, Giaccia AJ, Giudice L. Hypoxia stimulates insulin-like growth factor binding protein 1 (IGFBP-1) gene expression in HepG2 cells: a possible model for IGFBP-1 expression in fetal hypoxia. Proc Natl Acad Sci U S A. 1998 Aug 18; 95(17):10188-93. PMID: 9707622; PMCID: PMC21483.
    198. Giudice L, Mark SP, Irwin JC. Paracrine actions of insulin-like growth factors and IGF binding protein-1 in non-pregnant human endometrium and at the decidual-trophoblast interface. J Reprod Immunol. 1998 Aug; 39(1-2):133-48. PMID: 9786458.
      View in: PubMed
    199. Fisch JD, Ortiz BH, Tazuke SI, Chitkara U, Giudice L. Medical management of interstitial ectopic pregnancy: a case report and literature review. Hum Reprod. 1998 Jul; 13(7):1981-6. PMID: 9740461.
      View in: PubMed
    200. Azhar S, Tsai L, Medicherla S, Chandrasekher Y, Giudice L, Reaven E. Human granulosa cells use high density lipoprotein cholesterol for steroidogenesis. J Clin Endocrinol Metab. 1998 Mar; 83(3):983-91. PMID: 9506760.
      View in: PubMed
    201. Giudice L, Tazuke SI, Swiersz L. Status of current research on endometriosis. J Reprod Med. 1998 Mar; 43(3 Suppl):252-62. PMID: 9564658.
      View in: PubMed
    202. Irwin JC, Giudice L. Insulin-like growth factor binding protein-1 binds to placental cytotrophoblast alpha5beta1 integrin and inhibits cytotrophoblast invasion into decidualized endometrial stromal cultures. Growth Horm IGF Res. 1998 Feb; 8(1):21-31. PMID: 10990441.
      View in: PubMed
    203. Lee PD, Giudice L, Conover CA, Powell DR. Insulin-like growth factor binding protein-1: recent findings and new directions. Proc Soc Exp Biol Med. 1997 Dec; 216(3):319-57. PMID: 9402139.
      View in: PubMed
    204. Giudice L. Multifaceted roles for IGFBP-1 in human endometrium during implantation and pregnancy. Ann N Y Acad Sci. 1997 Sep 26; 828:146-56. PMID: 9329833.
      View in: PubMed
    205. Ulaner GA, Giudice L. Developmental regulation of telomerase activity in human fetal tissues during gestation. Mol Hum Reprod. 1997 Sep; 3(9):769-73. PMID: 9358002.
      View in: PubMed
    206. Yuan W, Giudice L. Programmed cell death in human ovary is a function of follicle and corpus luteum status. J Clin Endocrinol Metab. 1997 Sep; 82(9):3148-55. PMID: 9284760.
      View in: PubMed
    207. Yap OW, van Dessel HJ, Chandrasekher YA, Fauser BC, Giudice L. Insulin-like growth factors and insulin-like growth factor binding proteins in androgen-dominant ovarian follicles from testosterone-treated female-to-male trans-sexuals. Fertil Steril. 1997 Aug; 68(2):252-8. PMID: 9240252.
      View in: PubMed
    208. Martina NA, Kim E, Chitkara U, Wathen NC, Chard T, Giudice L. Gestational age-dependent expression of insulin-like growth factor-binding protein-1 (IGFBP-1) phosphoisoforms in human extraembryonic cavities, maternal serum, and decidua suggests decidua as the primary source of IGFBP-1 in these fluids during early pregnancy. J Clin Endocrinol Metab. 1997 Jun; 82(6):1894-8. PMID: 9177402.
      View in: PubMed
    209. Giudice L, Martina NA, Crystal RA, Tazuke S, Druzin M. Insulin-like growth factor binding protein-1 at the maternal-fetal interface and insulin-like growth factor-I, insulin-like growth factor-II, and insulin-like growth factor binding protein-1 in the circulation of women with severe preeclampsia. Am J Obstet Gynecol. 1997 Apr; 176(4):751-7; discussion 757-8. PMID: 9125598.
      View in: PubMed
    210. Amara DP, Nezhat F, Giudice L, Nezhat C. Laparoscopic management of a noncommunicating uterine horn in a patient with an acute abdomen. Surg Laparosc Endosc. 1997 Feb; 7(1):56-9. PMID: 9116951.
      View in: PubMed
    211. Sharara FI, Giudice L. Role of growth hormone in ovarian physiology and onset of puberty. J Soc Gynecol Investig. 1997 Jan-Feb; 4(1):2-7. PMID: 9051627.
      View in: PubMed
    212. Taskin O, Giudice L, Mangal R, Dunn RC, Dsupin BA, Poindexter AN, Wiehle RD. Insulin-like growth factor binding proteins in peritoneal fluid of women with minimal and mild endometriosis. Hum Reprod. 1996 Aug; 11(8):1741-6. PMID: 8921126.
      View in: PubMed
    213. Tazuke SI, Giudice L. Growth factors and cytokines in endometrium, embryonic development, and maternal: embryonic interactions. Semin Reprod Endocrinol. 1996 Aug; 14(3):231-45. PMID: 8885054.
      View in: PubMed
    214. Giudice L, Cataldo NA, van Dessel HJ, Yap OW, Chandrasekher YA. Growth factors in normal ovarian follicle development. Semin Reprod Endocrinol. 1996 Aug; 14(3):179-96. PMID: 8885049.
      View in: PubMed
    215. Giudice L, Morales AJ, Yen SS. Growth factors and polycystic ovarian syndrome. Semin Reprod Endocrinol. 1996 Aug; 14(3):203-8. PMID: 8885051.
      View in: PubMed
    216. Klein NA, Battaglia DE, Miller PB, Branigan EF, Giudice L, Soules MR. Ovarian follicular development and the follicular fluid hormones and growth factors in normal women of advanced reproductive age. J Clin Endocrinol Metab. 1996 May; 81(5):1946-51. PMID: 8626862.
      View in: PubMed
    217. Thierry van Dessel HJ, Chandrasekher Y, Yap OW, Lee PD, Hintz RL, Faessen GH, Braat DD, Fauser BC, Giudice L. Serum and follicular fluid levels of insulin-like growth factor I (IGF-I), IGF-II, and IGF-binding protein-1 and -3 during the normal menstrual cycle. J Clin Endocrinol Metab. 1996 Mar; 81(3):1224-31. PMID: 8772603.
      View in: PubMed
    218. Homburg R, Giudice L, Chang RJ. Polycystic ovary syndrome. Hum Reprod. 1996 Mar; 11(3):465-6. PMID: 8731178.
      View in: PubMed
    219. Poretsky L, Chandrasekher YA, Bai C, Liu HC, Rosenwaks Z, Giudice L. Insulin receptor mediates inhibitory effect of insulin, but not of insulin-like growth factor (IGF)-I, on IGF binding protein 1 (IGFBP-1) production in human granulosa cells. J Clin Endocrinol Metab. 1996 Feb; 81(2):493-6. PMID: 8636256.
      View in: PubMed
    220. Irwin JC, Kirk D, Gwatkin RB, Navre M, Cannon P, Giudice L. Human endometrial matrix metalloproteinase-2, a putative menstrual proteinase. Hormonal regulation in cultured stromal cells and messenger RNA expression during the menstrual cycle. J Clin Invest. 1996 Jan 15; 97(2):438-47. PMID: 8567965; PMCID: PMC507035.
    221. Gargosky SE, Giudice L, Rosenfeld RG, Fazleabas AT. Different molecular and messenger ribonucleic acid forms of insulin-like growth factor-binding protein-3 in the pregnant baboon (Papio anubis). J Endocrinol. 1995 Dec; 147(3):449-61. PMID: 8543915.
      View in: PubMed
    222. Chandrasekher YA, Van Dessel HJ, Fauser BC, Giudice L. Estrogen- but not androgen-dominant human ovarian follicular fluid contains an insulin-like growth factor binding protein-4 protease. J Clin Endocrinol Metab. 1995 Sep; 80(9):2734-9. PMID: 7545699.
      View in: PubMed
    223. Giudice L. IGF binding protein-3 protease regulation: how sweet it is! J Clin Endocrinol Metab. 1995 Aug; 80(8):2279-81. PMID: 7543109.
      View in: PubMed
    224. Madsen BL, Giudice L, Donaldson SS. Radiation-induced premature menopause: a misconception. Int J Radiat Oncol Biol Phys. 1995 Jul 30; 32(5):1461-4. PMID: 7635789.
      View in: PubMed
    225. Giudice L, de Zegher F, Gargosky SE, Dsupin BA, de las Fuentes L, Crystal RA, Hintz RL, Rosenfeld RG. Insulin-like growth factors and their binding proteins in the term and preterm human fetus and neonate with normal and extremes of intrauterine growth. J Clin Endocrinol Metab. 1995 May; 80(5):1548-55. PMID: 7538146.
      View in: PubMed
    226. Seifer DB, Giudice L, Dsupin BA, Haning RV, Frishman GN, Burger HG. Follicular fluid insulin-like growth factor-I and insulin-like growth factor-II concentrations vary as a function of day 3 serum follicle stimulating hormone. Hum Reprod. 1995 Apr; 10(4):804-6. PMID: 7650124.
      View in: PubMed
    227. Cummings LN, Giudice L, Morrell MJ. Ovulatory function in epilepsy. Epilepsia. 1995 Apr; 36(4):355-9. PMID: 7607113.
      View in: PubMed
    228. Giudice L, Saleh W. Growth factors in reproduction. Trends Endocrinol Metab. 1995 Mar; 6(2):60-9. PMID: 18406685.
      View in: PubMed
    229. Irwin JC, Dsupin BA, Giudice L. Regulation of insulin-like growth factor-binding protein-4 in human endometrial stromal cell cultures: evidence for ligand-induced proteolysis. J Clin Endocrinol Metab. 1995 Feb; 80(2):619-26. PMID: 7531715.
      View in: PubMed
    230. Giudice L. The insulin-like growth factor system in normal and abnormal human ovarian follicle development. Am J Med. 1995 Jan 16; 98(1A):48S-54S. PMID: 7825641.
      View in: PubMed
    231. Giudice L, van Dessel HJ, Cataldo NA, Chandrasekher YA, Yap OW, Fauser BC. Circulating and ovarian IGF binding proteins: potential roles in normo-ovulatory cycles and in polycystic ovarian syndrome. Prog Growth Factor Res. 1995; 6(2-4):397-408. PMID: 8817683.
      View in: PubMed
    232. Zhou J, Dsupin BA, Giudice L, Bondy CA. Insulin-like growth factor system gene expression in human endometrium during the menstrual cycle. J Clin Endocrinol Metab. 1994 Dec; 79(6):1723-34. PMID: 7527408.
      View in: PubMed
    233. Nonoshita LD, Wathen NC, Dsupin BA, Chard T, Giudice L. Insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), and proteolyzed IGFBP-3 in embryonic cavities in early human pregnancy: their potential relevance to maternal-embryonic and fetal interactions. J Clin Endocrinol Metab. 1994 Nov; 79(5):1249-55. PMID: 7525630.
      View in: PubMed
    234. Giudice L, Dsupin BA, Gargosky SE, Rosenfeld RG, Irwin JC. The insulin-like growth factor system in human peritoneal fluid: its effects on endometrial stromal cells and its potential relevance to endometriosis. J Clin Endocrinol Metab. 1994 Nov; 79(5):1284-93. PMID: 7525631.
      View in: PubMed
    235. Lee KO, Oh Y, Giudice L, Cohen P, Peehl DM, Rosenfeld RG. Identification of insulin-like growth factor-binding protein-3 (IGFBP-3) fragments and IGFBP-5 proteolytic activity in human seminal plasma: a comparison of normal and vasectomized patients. J Clin Endocrinol Metab. 1994 Nov; 79(5):1367-72. PMID: 7525634.
      View in: PubMed
    236. Irwin JC, de las Fuentes L, Giudice L. Growth factors and decidualization in vitro. Ann N Y Acad Sci. 1994 Sep 30; 734:7-18. PMID: 7526767.
      View in: PubMed
    237. Pannier EM, Irwin JC, Giudice L. Insulin-like growth factor-binding proteins in the human fetus: tissue-specific protein secretion, immunologic characterization, and gene expression. Am J Obstet Gynecol. 1994 Sep; 171(3):746-52. PMID: 7522398.
      View in: PubMed
    238. Rodgers WH, Matrisian LM, Giudice L, Dsupin B, Cannon P, Svitek C, Gorstein F, Osteen KG. Patterns of matrix metalloproteinase expression in cycling endometrium imply differential functions and regulation by steroid hormones. J Clin Invest. 1994 Sep; 94(3):946-53. PMID: 8083380; PMCID: PMC295134.
    239. Gordon JD, Hopkins KL, Jeffrey RB, Giudice L. Adnexal torsion: color Doppler diagnosis and laparoscopic treatment. Fertil Steril. 1994 Feb; 61(2):383-5. PMID: 8299800.
      View in: PubMed
    240. Giudice L. Growth factors and growth modulators in human uterine endometrium: their potential relevance to reproductive medicine. Fertil Steril. 1994 Jan; 61(1):1-17. PMID: 7507444.
      View in: PubMed
    241. Giudice L, Irwin JC, Dsupin BA, Pannier EM, Jin IH, Vu TH, Hoffman AR. Insulin-like growth factor (IGF), IGF binding protein (IGFBP), and IGF receptor gene expression and IGFBP synthesis in human uterine leiomyomata. Hum Reprod. 1993 Nov; 8(11):1796-806. PMID: 7507128.
      View in: PubMed
    242. Irwin JC, de las Fuentes L, Dsupin BA, Giudice L. Insulin-like growth factor regulation of human endometrial stromal cell function: coordinate effects on insulin-like growth factor binding protein-1, cell proliferation and prolactin secretion. Regul Pept. 1993 Oct 20; 48(1-2):165-77. PMID: 7505463.
      View in: PubMed
    243. Sanders LM, Giudice L, Raffin TA. Ethics of fetal tissue transplantation. West J Med. 1993 Sep; 159(3):400-7. PMID: 8236984; PMCID: PMC1011357.
    244. Giudice L, Chandrasekher YA, Cataldo NA. The potential roles of intraovarian peptides in normal and abnormal mechanisms of reproductive physiology. Curr Opin Obstet Gynecol. 1993 Jun; 5(3):350-9. PMID: 8329651.
      View in: PubMed
    245. Giudice L, Dsupin BA, Jin IH, Vu TH, Hoffman AR. Differential expression of messenger ribonucleic acids encoding insulin-like growth factors and their receptors in human uterine endometrium and decidua. J Clin Endocrinol Metab. 1993 May; 76(5):1115-22. PMID: 8496300.
      View in: PubMed
    246. Giudice L, Dsupin BA, De las Fuentes L, Gargosky SE, Rosenfeld RG, Zelinski-Wooten MB, Stouffer RL, Fazleabas AT. Insulin-like growth factor binding proteins in sera of pregnant nonhuman primates. Endocrinology. 1993 Apr; 132(4):1514-26. PMID: 7681762.
      View in: PubMed
    247. Rodgers WH, Osteen KG, Matrisian LM, Navre M, Giudice L, Gorstein F. Expression and localization of matrilysin, a matrix metalloproteinase, in human endometrium during the reproductive cycle. Am J Obstet Gynecol. 1993 Jan; 168(1 Pt 1):253-60. PMID: 8420336.
      View in: PubMed
    248. Woodruff TK, Battaglia J, Bowdidge A, Molskness TA, Stouffer RL, Cataldo NA, Giudice L, Orly J, Mather JP. Comparison of functional response of rat, macaque, and human ovarian cells in hormonally defined medium. Biol Reprod. 1993 Jan; 48(1):68-76. PMID: 8418917.
      View in: PubMed
    249. Cataldo NA, Woodruff TK, Giudice L. Regulation of insulin-like growth factor binding protein production by human luteinizing granulosa cells cultured in defined medium. J Clin Endocrinol Metab. 1993 Jan; 76(1):207-15. PMID: 7678423.
      View in: PubMed
    250. Gargosky SE, Pham HM, Wilson KF, Liu F, Giudice L, Rosenfeld RG. Measurement and characterization of insulin-like growth factor binding protein-3 in human biological fluids: discrepancies between radioimmunoassay and ligand blotting. Endocrinology. 1992 Dec; 131(6):3051-60. PMID: 1280211.
      View in: PubMed
    251. Milki AA, Hardy RI, el Danasouri I, Giudice L, Lamb EJ. Local anesthesia with conscious sedation for laparoscopic intrafallopian transfer. Fertil Steril. 1992 Dec; 58(6):1240-2. PMID: 1459278.
      View in: PubMed
    252. Giudice L. Insulin-like growth factors and ovarian follicular development. Endocr Rev. 1992 Nov; 13(4):641-69. PMID: 1281087.
      View in: PubMed
    253. Giudice L, Dsupin BA, Irwin JC. Steroid and peptide regulation of insulin-like growth factor-binding proteins secreted by human endometrial stromal cells is dependent on stromal differentiation. J Clin Endocrinol Metab. 1992 Nov; 75(5):1235-41. PMID: 1385468.
      View in: PubMed
    254. Cohen P, Graves HC, Peehl DM, Kamarei M, Giudice L, Rosenfeld RG. Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma. J Clin Endocrinol Metab. 1992 Oct; 75(4):1046-53. PMID: 1383255.
      View in: PubMed
    255. Cataldo NA, Giudice L. Insulin-like growth factor binding protein profiles in human ovarian follicular fluid correlate with follicular functional status. J Clin Endocrinol Metab. 1992 Apr; 74(4):821-9. PMID: 1372322.
      View in: PubMed
    256. Cataldo NA, Giudice L. Follicular fluid insulin-like growth factor binding protein profiles in polycystic ovary syndrome. J Clin Endocrinol Metab. 1992 Mar; 74(3):695-7. PMID: 1371292.
      View in: PubMed
    257. Giudice L, Dsupin BA, Irwin JC, Eckert RL. Identification of insulin-like growth factor binding proteins in human oviduct. Fertil Steril. 1992 Feb; 57(2):294-301. PMID: 1370941.
      View in: PubMed
    258. Donovan SM, Giudice L, Murphy LJ, Hintz RL, Rosenfeld RG. Maternal insulin-like growth factor-binding protein messenger ribonucleic acid during rat pregnancy. Endocrinology. 1991 Dec; 129(6):3359-66. PMID: 1720094.
      View in: PubMed
    259. Giudice L, Milki AA, Milkowski DA, el Danasouri I. Human granulosa contain messenger ribonucleic acids encoding insulin-like growth factor-binding proteins (IGFBPs) and secrete IGFBPs in culture. Fertil Steril. 1991 Sep; 56(3):475-80. PMID: 1716597.
      View in: PubMed
    260. Lamson G, Giudice L, Rosenfeld RG. A simple assay for proteolysis of IGFBP-3. J Clin Endocrinol Metab. 1991 Jun; 72(6):1391-3. PMID: 1709177.
      View in: PubMed
    261. Giudice L, Milkowski DA, Fielder PJ, Irwin JC. Characterization of the steroid-dependence of insulin-like growth factor-binding protein-2 synthesis and mRNA expression in cultured human endometrial stromal cells. Hum Reprod. 1991 May; 6(5):632-40. PMID: 1719019.
      View in: PubMed
    262. Giudice L, Milkowski DA, Lamson G, Rosenfeld RG, Irwin JC. Insulin-like growth factor binding proteins in human endometrium: steroid-dependent messenger ribonucleic acid expression and protein synthesis. J Clin Endocrinol Metab. 1991 Apr; 72(4):779-87. PMID: 1706350.
      View in: PubMed
    263. Lamson G, Giudice L, Rosenfeld RG. Insulin-like growth factor binding proteins: structural and molecular relationships. Growth Factors. 1991; 5(1):19-28. PMID: 1722987.
      View in: PubMed
    264. Cohen P, Fielder PJ, Hasegawa Y, Frisch H, Giudice L, Rosenfeld RG. Clinical aspects of insulin-like growth factor binding proteins. Acta Endocrinol (Copenh). 1991; 124 Suppl 2:74-85. PMID: 1713010.
      View in: PubMed
    265. Giudice L, Lamson G, Rosenfeld RG, Irwin JC. Insulin-like growth factor-II (IGF-II) and IGF binding proteins in human endometrium. Ann N Y Acad Sci. 1991; 626:295-307. PMID: 1711826.
      View in: PubMed
    266. Giudice L, Farrell EM, Pham H, Rosenfeld RG. Identification of insulin-like growth factor-binding protein-3 (IGFBP-3) and IGFBP-2 in human follicular fluid. J Clin Endocrinol Metab. 1990 Nov; 71(5):1330-8. PMID: 1699963.
      View in: PubMed
    267. Giudice L, Farrell EM, Pham H, Lamson G, Rosenfeld RG. Insulin-like growth factor binding proteins in maternal serum throughout gestation and in the puerperium: effects of a pregnancy-associated serum protease activity. J Clin Endocrinol Metab. 1990 Oct; 71(4):806-16. PMID: 1698200.
      View in: PubMed
    268. Rosenfeld RG, Pham H, Oh Y, Lamson G, Giudice L. Identification of insulin-like growth factor-binding protein-2 (IGF-BP-2) and a low molecular weight IGF-BP in human seminal plasma. J Clin Endocrinol Metab. 1990 Feb; 70(2):551-3. PMID: 1688870.
      View in: PubMed
    269. Rosenfeld RG, Lamson G, Pham H, Oh Y, Conover C, De Leon DD, Donovan SM, Ocrant I, Giudice L. Insulinlike growth factor-binding proteins. Recent Prog Horm Res. 1990; 46:99-159; discussion 159-63. PMID: 1704143.
      View in: PubMed
    270. Lamson G, Oh Y, Pham H, Giudice L, Rosenfeld RG. Expression of two insulin-like growth factor-binding proteins in a human endometrial cancer cell line: structural, immunological, and genetic characterization. J Clin Endocrinol Metab. 1989 Oct; 69(4):852-9. PMID: 2550507.
      View in: PubMed
    271. Friedler S, Giudice L, Lamb EJ. Cryopreservation of embryos and ova. Fertil Steril. 1988 May; 49(5):743-64. PMID: 3282929.
      View in: PubMed
    272. Kivikoski AI, Martin C, Weyman P, Picus D, Giudice L. Angiographic arterial embolization to control hemorrhage in abdominal pregnancy: a case report. Obstet Gynecol. 1988 Mar; 71(3 Pt 2):456-9. PMID: 3347434.
      View in: PubMed
    273. Sauer MV, Macaso TM, Ishida EH, Giudice L, Marshall JR, Buster JE. Pregnancy following nonsurgical donor ovum transfer to a functionally agonadal woman. Fertil Steril. 1987 Aug; 48(2):324-5. PMID: 3609344.
      View in: PubMed
    274. Lamb EJ, Polansky F, Milki A, Giudice L, Friedler S, Wu T, Shen E, Turner K, Ho L. Clinical results of Stanford University's in vitro fertilization and embryo transfer program. J In Vitro Fert Embryo Transf. 1987 Jun; 4(3):188-9. PMID: 3611930.
      View in: PubMed
    275. Giudice L, Jacobs A, Pineda J, Bell CE, Lippmann L. Serum levels of CA-125 in patients with endometriosis: a preliminary report. Fertil Steril. 1986 Jun; 45(6):876-8. PMID: 3458595.
      View in: PubMed
    276. Pierce JG, Bloomfield GA, Giudice L. The function of the common subunit of glycoprotein hormones. Biochem Soc Trans. 1978; 6(1):57-60. PMID: 640204.
      View in: PubMed
    277. Giudice L, Pierce JG. Separation of functional and non-functional beta subunits of thyrotropin preparations by polyacrylamide gel electrophoresis. Endocrinology. 1977 Sep; 101(3):776-81. PMID: 408127.
      View in: PubMed
    278. Pierce JG, Giudice L, Reeve JR. Studies on the disulfide bonds of glycoprotein hormones. Course of reduction of bovine luteinizing hormone, bovine thyroid-stimulating hormone, and their subunits. J Biol Chem. 1976 Oct 25; 251(20):6388-91. PMID: 988020.
      View in: PubMed
    279. Giudice L, Pierce JG. Studies on the disulfide bonds of glycoprotein hormones. Complete reduction and reoxidation of the disulfide bonds of the alpha subunit of bovine luteinizing hormone. J Biol Chem. 1976 Oct 25; 251(20):6392-9. PMID: 988021.
      View in: PubMed
    280. Pierce JG, Faith MR, Giudice L, Reeve JR. Structure and structure-function relationships in glycoprotein hormones. Ciba Found Symp. 1976; 41:225-50. PMID: 780075.
      View in: PubMed
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