Ankit Khambhati, PhD

Title(s)Assistant Professor, Neurological Surgery
SchoolSchool of Medicine
Address1651 4th Street, #671J
San Francisco CA 94158
ORCID ORCID Icon0000-0001-6182-4677 Additional info
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


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    Carnegie Mellon University, Pittsburgh, PAB.S.05/2009Electrical and Computer Engineering
    University of Pennsylvania, Philadelphia, PAM.S.08/2010Bioengineering
    University of Pennsylvania, Philadelphia, PAPhD12/2015Bioengineering
    University of California, San Francisco, San Francisco, CAPostdoc01/2022Neuroengineering

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    Dr. Ankit Khambhati, PhD, is an Assistant Professor in Residence in the Department of Neurological Surgery at UCSF. He is trained as an electrical and biomedical engineer, and his technical expertise lies at the intersection of network neuroscience, machine learning, and complex systems. Khambhati's research seeks to understand the organization of human brain circuits and how disruption of these circuits give rise to functional brain network disorders.

    At UCSF, Khambhati leads a research program specialized in the development of network neurotechnology to map and modulate the neural pathways that facilitate large-scale communication within interconnected brain networks. His research group uses a multi-modal approach that integrates network science and control theory with direct brain electrical recordings, implantable devices, and neurostimulation to develop strategies for brain network control and repair. As a collaborator on highly interdisciplinary teams, he investigates the translational potential of this technology for treatment-resistant neuropsychiatric disorders.

    Khambhati earned his bachelor’s degree in electrical and computer engineering from Carnegie Mellon University and his doctorate in bioengineering from the University of Pennsylvania. He completed a postdoctoral fellowship in neuroengineering at UCSF. He is a member of the American Epilepsy Society and the Institute of Electrical and Electronics Engineers.

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    Stochastic, Multi-Electrode Stimulation to Probe and Perturb Abnormal Synchronization in the Human Epileptic Network
    Citizens United for Research in Epilepsy (CURE) Taking Flight AwardJul 1, 2020 - Jun 30, 2021
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. State-dependent effects of responsive neurostimulation depend on seizure localization. Brain. 2024 Jul 25. Chiang S, Khambhati AN, Tcheng TK, Loftman AP, Hasulak NR, Mirro EA, Morrell MJ, Rao VR. PMID: 39052924.
      View in: PubMed   Mentions:    Fields:    
    2. Hippocampal network activity forecasts epileptic seizures. Nat Med. 2024 Oct; 30(10):2787-2790. Khambhati AN, Chang EF, Baud MO, Rao VR. PMID: 38997606.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    3. Graph and Network Control Theoretic Frameworks. Statistical Methods in Epilepsy. 2024 Mar 25; 143-165. Khambhati KA, Chiang CS. .
      View in: Publisher Site   Mentions:
    4. Corticography and human intracranial neurophysiology. Reference Module in Neuroscience and Biobehavioral Psychology. 2024 Jan 1. Zhao ZL, Khambhati KA, Hullett HP, Chang CE. .
      View in: Publisher Site   Mentions:
    5. Utility of Chronic Intracranial Electroencephalography in Responsive Neurostimulation Therapy. Neurosurg Clin N Am. 2024 Jan; 35(1):125-133. Khambhati AN. PMID: 38000836.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder. J Vis Exp. 2023 07 07; (197). Sellers KK, Khambhati AN, Stapper N, Fan JM, Rao VR, Scangos KW, Chang EF, Krystal AD. PMID: 37486114.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    7. Intracranial electrical stimulation of corticolimbic sites modulates arousal in humans. Brain Stimul. 2023 Jul-Aug; 16(4):1072-1082. Fan JM, Lee AM, Sellers KK, Woodworth K, Makhoul GS, Liu TX, Henderson C, Astudillo Maya DA, Martinez R, Zamanian H, Speidel BA, Khambhati AN, Rao VR, Sugrue LP, Scangos KW, Chang EF, Krystal AD. PMID: 37385540; PMCID: PMC10634663.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    8. Closed-loop neurostimulation for the treatment of psychiatric disorders. Neuropsychopharmacology. 2024 Jan; 49(1):163-178. Sellers KK, Cohen JL, Khambhati AN, Fan JM, Lee AM, Chang EF, Krystal AD. PMID: 37369777; PMCID: PMC10700557.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    9. 46. Amygdala-Hippocampus Coherence is a Biomarker of Predominant Symptom Sets in Patients With Depression. Biological Psychiatry. 2023 May 1; 93(9):s112-s113. Cohen CJ, Fan FJ, Sellers SK, Khambhati KA, Dawes DH, Scangos SK, Rao RV, Sugrue SL, Starr SP, Chang CE, Krystal KA. .
      View in: Publisher Site   Mentions:
    10. Epileptiform discharges triggered with direct electrical stimulation for treatment-resistant depression: Factors that modulate risk and treatment considerations. Brain Stimul. 2023 Mar-Apr; 16(2):462-465. Fan JM, Khambhati AN, Sellers KK, Stapper N, Maya DA, Kunwar E, Henderson C, Sugrue LP, Scangos KW, Chang EF, Rao VR, Krystal AD. PMID: 36773780; PMCID: PMC10627048.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Changes in intracranial neurophysiology associated with acute COVID-19 infection. Clin Neurophysiol. 2023 04; 148:29-31. Sellers KK, Stapper N, Astudillo Maya DA, Henderson C, Khambhati AN, Fan JM, Rao VR, Scangos KW, Chang EF, Krystal AD. PMID: 36791656; PMCID: PMC9896881.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Decoding naturalistic affective behaviour from spectro-spatial features in multiday human iEEG. Nat Hum Behav. 2022 06; 6(6):823-836. Bijanzadeh M, Khambhati AN, Desai M, Wallace DL, Shafi A, Dawes HE, Sturm VE, Chang EF. PMID: 35273355; PMCID: PMC9232980.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    13. Intracranial electroencephalographic biomarker predicts effective responsive neurostimulation for epilepsy prior to treatment. Epilepsia. 2022 03; 63(3):652-662. Scheid BH, Bernabei JM, Khambhati AN, Mouchtaris S, Jeschke J, Bassett DS, Becker D, Davis KA, Lucas T, Doyle W, Chang EF, Friedman D, Rao VR, Litt B. PMID: 34997577; PMCID: PMC9887634.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    14. Distributed Subnetworks of Depression Defined by Direct Intracranial Neurophysiology. Front Hum Neurosci. 2021; 15:746499. Scangos KW, Khambhati AN, Daly PM, Owen LW, Manning JR, Ambrose JB, Austin E, Dawes HE, Krystal AD, Chang EF. PMID: 34744662; PMCID: PMC8566975.
      View in: PubMed   Mentions: 8  
    15. Closed-loop neuromodulation in an individual with treatment-resistant depression. Nat Med. 2021 10; 27(10):1696-1700. Scangos KW, Khambhati AN, Daly PM, Makhoul GS, Sugrue LP, Zamanian H, Liu TX, Rao VR, Sellers KK, Dawes HE, Starr PA, Krystal AD, Chang EF. PMID: 34608328; PMCID: PMC11219029.
      View in: PubMed   Mentions: 124     Fields:    Translation:Humans
    16. Long-term brain network reorganization predicts responsive neurostimulation outcomes for focal epilepsy. Sci Transl Med. 2021 08 25; 13(608). Khambhati AN, Shafi A, Rao VR, Chang EF. PMID: 34433640.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    17. Effects of anterior thalamic nuclei stimulation on hippocampal activity: Chronic recording in a patient with drug-resistant focal epilepsy. Epilepsy Behav Rep. 2021; 16:100467. Silva AB, Khambhati AN, Speidel BA, Chang EF, Rao VR. PMID: 34458713; PMCID: PMC8379668.
      View in: PubMed   Mentions: 7  
    18. Evidence of state-dependence in the effectiveness of responsive neurostimulation for seizure modulation. Brain Stimul. 2021 Mar-Apr; 14(2):366-375. Chiang S, Khambhati AN, Wang ET, Vannucci M, Chang EF, Rao VR. PMID: 33556620; PMCID: PMC8083819.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    19. Early seizure spread and epilepsy surgery: A systematic review. Epilepsia. 2020 10; 61(10):2163-2172. Andrews JP, Ammanuel S, Kleen J, Khambhati AN, Knowlton R, Chang EF. PMID: 32944952; PMCID: PMC8139824.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    20. Corticocortical Evoked Potentials and Patient Response Reveal Networks Underlying Depression. Biological Psychiatry. 2020 May 1; 87(9):s157. Scangos SK, Makhoul MG, Khambhati KA, Sellers SK, Chang CE, Krystal KA. .
      View in: Publisher Site   Mentions:
    21. Functional brain network reconfiguration during learning in a dynamic environment. Nat Commun. 2020 04 03; 11(1):1682. Kao CH, Khambhati AN, Bassett DS, Nassar MR, McGuire JT, Gold JI, Kable JW. PMID: 32245973; PMCID: PMC7125157.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    22. Model-based design for seizure control by stimulation. J Neural Eng. 2020 03 26; 17(2):026009. Ashourvan A, Pequito S, Khambhati AN, Mikhail F, Baldassano SN, Davis KA, Lucas TH, Vettel JM, Litt B, Pappas GJ, Bassett DS. PMID: 32103826; PMCID: PMC8341467.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    23. Emerging roles of network analysis for epilepsy. Epilepsy Res. 2020 01; 159:106255. Stacey W, Kramer M, Gunnarsdottir K, Gonzalez-Martinez J, Zaghloul K, Inati S, Sarma S, Stiso J, Khambhati AN, Bassett DS, Smith RJ, Liu VB, Lopour BA, Staba R. PMID: 31855828; PMCID: PMC6990460.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    24. Virtual resection predicts surgical outcome for drug-resistant epilepsy. Brain. 2019 12 01; 142(12):3892-3905. Kini LG, Bernabei JM, Mikhail F, Hadar P, Shah P, Khambhati AN, Oechsel K, Archer R, Boccanfuso J, Conrad E, Shinohara RT, Stein JM, Das S, Kheder A, Lucas TH, Davis KA, Bassett DS, Litt B. PMID: 31599323; PMCID: PMC6885672.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    25. White Matter Network Architecture Guides Direct Electrical Stimulation through Optimal State Transitions. Cell Rep. 2019 Sep 03; 28(10):2554-2566.e7. Stiso J, Khambhati AN, Menara T, Kahn AE, Stein JM, Das SR, Gorniak R, Tracy J, Litt B, Davis KA, Pasqualetti F, Lucas TH, Bassett DS. PMID: 31484068; PMCID: PMC6849479.
      View in: PubMed   Mentions: 60     Fields:    Translation:Humans
    26. Functional control of electrophysiological network architecture using direct neurostimulation in humans. Netw Neurosci. 2019; 3(3):848-877. Khambhati AN, Kahn AE, Costantini J, Ezzyat Y, Solomon EA, Gross RE, Jobst BC, Sheth SA, Zaghloul KA, Worrell G, Seger S, Lega BC, Weiss S, Sperling MR, Gorniak R, Das SR, Stein JM, Rizzuto DS, Kahana MJ, Lucas TH, Davis KA, Tracy JI, Bassett DS. PMID: 31410383; PMCID: PMC6663306.
      View in: PubMed   Mentions: 29  
    27. O20. Resting State Whole Brain Network Activity in Depression From Intracranial EEG Signals. Biological Psychiatry. 2019 May 1; 85(10):s113-s114. Scangos SK, Khambhati KA, Daly DP, Shafi SA, Dawes DH, Krystal KA, Chang CE. .
      View in: Publisher Site   Mentions:
    28. Virtual Cortical Resection Reveals Epileptic Network Characteristics in Pediatric Patients with Focal Cortical Dysplasia. (S36.003). Neurology. 2019 Apr 9; 92(15_supplement). Wong WJ, Tomlinson TS, Conrad CE, Khambhati KA, Marsh ME. .
      View in: Publisher Site   Mentions:
    29. 126 Postictal EEG Activity in Pediatric and Adult Patients Undergoing Epilepsy Surgery: A Network Perspective. Neurosurgery. 2018 Sep 1; 65(CN_suppl_1):89-89. Tomlinson TS, Khambhati KA, Kamens KR, Porter PB, Marsh ME. .
      View in: Publisher Site   Mentions:
    30. Correction: Subgraphs of functional brain networks identify dynamical constraints of cognitive control. PLoS Comput Biol. 2018 08; 14(8):e1006420. Khambhati AN, Medaglia JD, Karuza EA, Thompson-Schill SL, Bassett DS. PMID: 30153248; PMCID: PMC6112641.
      View in: PubMed   Mentions: 1     Fields:    
    31. Subgraphs of functional brain networks identify dynamical constraints of cognitive control. PLoS Comput Biol. 2018 07; 14(7):e1006234. Khambhati AN, Medaglia JD, Karuza EA, Thompson-Schill SL, Bassett DS. PMID: 29979673; PMCID: PMC6056061.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    32. Alterations of network synchrony after epileptic seizures: An analysis of post-ictal intracranial recordings in pediatric epilepsy patients. Epilepsy Res. 2018 07; 143:41-49. Tomlinson SB, Khambhati AN, Bermudez C, Kamens RM, Heuer GG, Porter BE, Marsh ED. PMID: 29655171; PMCID: PMC7003130.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    33. Integrating EEG and MEG Signals to Improve Motor Imagery Classification in Brain-Computer Interface. Int J Neural Syst. 2019 Feb; 29(1):1850014. Corsi MC, Chavez M, Schwartz D, Hugueville L, Khambhati AN, Bassett DS, De Vico Fallani F. PMID: 29768971.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    34. Beyond modularity: Fine-scale mechanisms and rules for brain network reconfiguration. Neuroimage. 2018 02 01; 166:385-399. Khambhati AN, Mattar MG, Wymbs NF, Grafton ST, Bassett DS. PMID: 29138087.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    35. Modeling and interpreting mesoscale network dynamics. Neuroimage. 2018 10 15; 180(Pt B):337-349. Khambhati AN, Sizemore AE, Betzel RF, Bassett DS. PMID: 28645844; PMCID: PMC5738302.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    36. Crowdsourcing seizure detection: algorithm development and validation on human implanted device recordings. Brain. 2017 Jun 01; 140(6):1680-1691. Baldassano SN, Brinkmann BH, Ung H, Blevins T, Conrad EC, Leyde K, Cook MJ, Khambhati AN, Wagenaar JB, Worrell GA, Litt B. PMID: 28459961; PMCID: PMC6075622.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimals
    37. A network engineering perspective on probing and perturbing cognition with neurofeedback. Ann N Y Acad Sci. 2017 05; 1396(1):126-143. Bassett DS, Khambhati AN. PMID: 28445589; PMCID: PMC5446287.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    38. Emerging Frontiers of Neuroengineering: A Network Science of Brain Connectivity. Annu Rev Biomed Eng. 2017 06 21; 19:327-352. Bassett DS, Khambhati AN, Grafton ST. PMID: 28375650; PMCID: PMC6005206.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    39. Recurring Functional Interactions Predict Network Architecture of Interictal and Ictal States in Neocortical Epilepsy. eNeuro. 2017 Jan-Feb; 4(1). Khambhati AN, Bassett DS, Oommen BS, Chen SH, Lucas TH, Davis KA, Litt B. PMID: 28303256; PMCID: PMC5343278.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    40. Evolution of brain network dynamics in neurodevelopment. Netw Neurosci. 2017; 1(1):14-30. Chai LR, Khambhati AN, Ciric R, Moore TM, Gur RC, Gur RE, Satterthwaite TD, Bassett DS. PMID: 30793068; PMCID: PMC6330215.
      View in: PubMed   Mentions: 48  
    41. Virtual Cortical Resection Reveals Push-Pull Network Control Preceding Seizure Evolution. Neuron. 2016 Sep 07; 91(5):1170-1182. Khambhati AN, Davis KA, Lucas TH, Litt B, Bassett DS. PMID: 27568515; PMCID: PMC5017915.
      View in: PubMed   Mentions: 95     Fields:    Translation:Humans
    42. A Powerful DREADD: Revealing Structural Drivers of Functional Dynamics. Neuron. 2016 07 20; 91(2):213-5. Khambhati AN, Bassett DS. PMID: 27477013.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    43. Dynamic Network Drivers of Seizure Generation, Propagation and Termination in Human Neocortical Epilepsy. PLoS Comput Biol. 2015 Dec; 11(12):e1004608. Khambhati AN, Davis KA, Oommen BS, Chen SH, Lucas TH, Litt B, Bassett DS. PMID: 26680762; PMCID: PMC4682976.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansCells
    44. A translational platform for prototyping closed-loop neuromodulation systems. Front Neural Circuits. 2012; 6:117. Afshar P, Khambhati A, Stanslaski S, Carlson D, Jensen R, Linde D, Dani S, Lazarewicz M, Cong P, Giftakis J, Stypulkowski P, Denison T. PMID: 23346048; PMCID: PMC3551193.
      View in: PubMed   Mentions: 58     Fields:    
    45. Neural dynamics of image representation in the primary visual cortex. J Physiol Paris. 2012 Sep-Dec; 106(5-6):250-65. Yan X, Khambhati A, Liu L, Lee TS. PMID: 22944076; PMCID: PMC3767142.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
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