Jonathan Kleen, MD, PhD

InstitutionUniversity of California San Francisco
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    Cognitive impact of iterictal spikes in temporal lobe epilepsy
    NIH F30NS064624Jan 1, 2009 - Jun 30, 2014
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Baud MO, Kleen J, Mirro EA, Andrechak JC, King-Stephens D, Chang EF, Rao VR. Multi-day rhythms modulate seizure risk in epilepsy. Nat Commun. 2018 Jan 08; 9(1):88. PMID: 29311566.
      View in: PubMed
    2. Baud MO, Kleen J, Anumanchipalli GK, Hamilton LS, Tan YL, Knowlton R, Chang EF. Unsupervised Learning of Spatiotemporal Interictal Discharges in Focal Epilepsy. Neurosurgery. 2017 Oct 10. PMID: 29040672.
      View in: PubMed
    3. Kleen J, Kirsch HE. The nociferous influence of interictal discharges on memory. Brain. 2017 Aug 01; 140(8):2072-2074. PMID: 28899025.
      View in: PubMed
    4. Rao VR, Leonard MK, Kleen J, Lucas BA, Mirro EA, Chang EF. Chronic ambulatory electrocorticography from human speech cortex. Neuroimage. 2017 Jun; 153:273-282. PMID: 28396294.
      View in: PubMed
    5. Kleen J, Lowenstein DH. Progress in Epilepsy: Latest Waves of Discovery. JAMA Neurol. 2017 Feb 01; 74(2):139-140. PMID: 27918766.
      View in: PubMed
    6. Kleen J, Levin M. Injection Therapy for Headache and Facial Pain. Oral Maxillofac Surg Clin North Am. 2016 Aug; 28(3):423-34. PMID: 27475516.
      View in: PubMed
    7. Kleen J, Testorf ME, Roberts DW, Scott RC, Jobst BJ, Holmes GL, Lenck-Santini PP. Oscillation Phase Locking and Late ERP Components of Intracranial Hippocampal Recordings Correlate to Patient Performance in a Working Memory Task. Front Hum Neurosci. 2016; 10:287. PMID: 27378885; PMCID: PMC4910536.
    8. Thomas AA, Fisher JL, Rahme GJ, Hampton TH, Baron U, Olek S, Schwachula T, Rhodes CH, Gui J, Tafe LJ, Tsongalis GJ, Lefferts JA, Wishart H, Kleen J, Miller M, Whipple CA, de Abreu FB, Ernstoff MS, Fadul CE. Regulatory T cells are not a strong predictor of survival for patients with glioblastoma. Neuro Oncol. 2015 Jun; 17(6):801-9. PMID: 25618892; PMCID: PMC4483125.
    9. Kleen J, Scott RC, Holmes GL, Roberts DW, Rundle MM, Testorf M, Lenck-Santini PP, Jobst BC. Hippocampal interictal epileptiform activity disrupts cognition in humans. Neurology. 2013 Jul 02; 81(1):18-24. PMID: 23685931; PMCID: PMC3770206.
    10. Kleen J, Wu EX, Holmes GL, Scott RC, Lenck-Santini PP. Enhanced oscillatory activity in the hippocampal-prefrontal network is related to short-term memory function after early-life seizures. J Neurosci. 2011 Oct 26; 31(43):15397-406. PMID: 22031886; PMCID: PMC3224083.
    11. Kleen J, Sesqué A, Wu EX, Miller FA, Hernan AE, Holmes GL, Scott RC. Early-life seizures produce lasting alterations in the structure and function of the prefrontal cortex. Epilepsy Behav. 2011 Oct; 22(2):214-9. PMID: 21873119; PMCID: PMC3185212.
    12. Isaev D, Zhao Q, Kleen J, Lenck-Santini PP, Adstamongkonkul D, Isaeva E, Holmes GL. Neuroaminidase reduces interictal spikes in a rat temporal lobe epilepsy model. Epilepsia. 2011 Mar; 52(3):e12-5. PMID: 21366554; PMCID: PMC3265164.
    13. Kleen J, Holmes GL. Taming TLR4 may ease seizures. Nat Med. 2010 Apr; 16(4):369-70. PMID: 20376038.
      View in: PubMed
    14. Kleen J, Scott RC, Holmes GL, Lenck-Santini PP. Hippocampal interictal spikes disrupt cognition in rats. Ann Neurol. 2010 Feb; 67(2):250-7. PMID: 20225290; PMCID: PMC2926932.
    15. Kleen J, Holmes GL. Brain inflammation initiates seizures. Nat Med. 2008 Dec; 14(12):1309-10. PMID: 19057551.
      View in: PubMed
    16. Kleen J, Sitomer MT, Killeen PR, Conrad CD. Chronic stress impairs spatial memory and motivation for reward without disrupting motor ability and motivation to explore. Behav Neurosci. 2006 Aug; 120(4):842-51. PMID: 16893290; PMCID: PMC1578508.
    17. Baran SE, Campbell AM, Kleen J, Foltz CH, Wright RL, Diamond DM, Conrad CD. Combination of high fat diet and chronic stress retracts hippocampal dendrites. Neuroreport. 2005 Jan 19; 16(1):39-43. PMID: 15618887; PMCID: PMC1363787.
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