Jon Kleen, MD, PhD

Title(s)Assistant Professor, Neurology
SchoolSchool of Medicine
ORCID ORCID Icon0000-0003-2622-3205 Additional info
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences

    Collapse Biography 
    Collapse Education and Training
    UCSF Medical Center, San Francisco, CA2020Diversity, Equity, and Inclusion Champion Training
    UCSF Medical CenterFellowship2019Epilepsy
    UCSF Medical CenterResidency2017Neurology
    Dartmouth Medical SchoolM.D.2013Medicine
    Dartmouth Medical SchoolPh.D.2011Neuroscience
    Collapse Awards and Honors
    American Academy of Neurology20232023 Dreifuss-Penry Epilepsy Award
    American Neurological Association (AAN)2022Emerging Scholar Award
    National Science Foundation (NSF)2022  - 2025CogNeuro Award
    UCSF Medical School2022Bridges Curriculum Award for Inspirational Teaching
    2022NIH BRAIN Initiative Photo & Video Contest (2nd Place)
    Weill Institute for Neurosciences2020Weill Pilot Award for Junior Investigators in the Neurosciences
    NINDS / National Institutes of Health2019  - 2024K23 Career Development Award
    San Francisco Neurological Society (SFNS)2019Boldrey Young Investigator Award
    American Epilepsy Society (AES)2018Young Investigator Award
    Alpha Omega Alpha (AOA) Honor Medical Society2017Resident Physician Inductee

    Collapse Overview 
    Collapse Overview
    Dr. Jon Kleen is a neurologist who specializes in epilepsy care. He is dedicated to improving the lives of patients with epilepsy by stopping seizures and finding new ways to overcome epilepsy-related cognitive issues, such as memory problems.

    Kleen is a neuroscientist with expertise in signal processing (the use of computers to study patterns in large amounts of data), which he applies to cutting-edge diagnostic approaches and emerging therapies for epilepsy, including brain stimulation. As part of his research, he investigates how memory circuits work in the human brain and why they are disrupted in many people with epilepsy. He also develops technology that integrates brainwave recordings with brain images to help pinpoint where seizures start, with the goal of increasing the chance for future curative surgery in patients whose prior treatments failed.

    Kleen is originally from rural Minnesota. He earned a doctorate in neuroscience from Dartmouth College and his medical degree from Dartmouth Medical School. At UCSF, he completed a residency in neurology, serving as chief resident, and a fellowship in epilepsy. He also completed postdoctoral training in human neurophysiology at UCSF. In 2017, he was elected by UCSF medical students for membership in UCSF's chapter of Alpha Omega Alpha for excellence in teaching.

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    Collapse Research 
    Collapse Research Activities and Funding
    Understanding mechanisms of semantic memory through intracranial recording and stimulation
    NSF CogNeuro 2148753Sep 1, 2022 - Aug 30, 2025
    Novel cinematic technology to localize intracranial seizure activity in medically-refractory epilepsy
    Weill Institute for Neurosciences Weill Pilot Award for Junior InvestigatorsFeb 1, 2020 - Jul 31, 2021
    Role: Principle Investigator
    Hippocampal-cortical networks underlying memory retrieval of linguistic knowledge
    NIH K23NS110920Jul 1, 2019 - Jun 30, 2024
    Role: Principal Investigator
    Cognitive impact of iterictal spikes in temporal lobe epilepsy
    NIH F30NS064624Jan 1, 2009 - Jun 30, 2014
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Development and validation of a nonverbal consensus-based semantic memory paradigm in patients with epilepsy. J Int Neuropsychol Soc. 2024 Apr 15; 1-9. Tran EB, Vonk JMJ, Casaletto K, Zhang D, Christin R, Marathe S, Gorno-Tempini ML, Chang EF, Kleen JK. PMID: 38616725.
      View in: PubMed   Mentions:
    2. Interictal epileptiform discharges contribute to word-finding difficulty in epilepsy through multiple cognitive mechanisms. Epilepsia. 2023 Dec; 64(12):3266-3278. Silva AB, Leonard MK, Oganian Y, D'Esopo E, Krish D, Kopald B, Tran EB, Chang EF, Kleen JK. PMID: 37753856; PMCID: PMC10841419.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Ictal EEG Source Imaging With Supplemental Electrodes. J Clin Neurophysiol. 2023 Oct 05. Loube DK, Tan YL, Yoshii-Contreras J, Kleen J, Rao VR, Chang EF, Knowlton RC. PMID: 37820169.
      View in: PubMed   Mentions:    Fields:    
    4. Clinical Reasoning: A Young Adult With New Seizures and Chapeau de Gendarme. Neurology. 2023 10 31; 101(18):e1821-e1827. Valdrighi A, Douglas AG, Knowlton RC, Shah M, Kleen JK. PMID: 37580161; PMCID: PMC10634645.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. The New Era of Automated Electroencephalogram Interpretation. JAMA Neurol. 2023 08 01; 80(8):777-778. Kleen JK, Guterman EL. PMID: 37338899.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Is It Reasonable to Drive When There Is a (Spike) Train? Neurology. 2023 08 29; 101(9):377-379. Kleen JK, Davis KA. PMID: 37414566.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Intact speech perception after resection of dominant hemisphere primary auditory cortex for the treatment of medically refractory epilepsy: illustrative case. J Neurosurg Case Lessons. 2022 Nov 28; 4(22). Hullett PW, Kandahari N, Shih TT, Kleen JK, Knowlton RC, Rao VR, Chang EF. PMID: 36443954; PMCID: PMC9705521.
      View in: PubMed   Mentions:
    8. Bidirectional propagation of low frequency oscillations over the human hippocampal surface. Nat Commun. 2021 05 12; 12(1):2764. Kleen JK, Chung JE, Sellers KK, Zhou J, Triplett M, Lee K, Tooker A, Haque R, Chang EF. PMID: 33980852; PMCID: PMC8115072.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    9. Accuracy of omni-planar and surface casting of epileptiform activity for intracranial seizure localization. Epilepsia. 2021 04; 62(4):947-959. Kleen JK, Speidel BA, Baud MO, Rao VR, Ammanuel SG, Hamilton LS, Chang EF, Knowlton RC. PMID: 33634855; PMCID: PMC8276628.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    10. Measuring synchrony in bio-medical timeseries. Chaos. 2021 Jan; 31(1):013138. Leguia MG, Rao VR, Kleen JK, Baud MO. PMID: 33754758.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    11. Early seizure spread and epilepsy surgery: A systematic review. Epilepsia. 2020 10; 61(10):2163-2172. Andrews JP, Ammanuel S, Kleen J, Khambhati AN, Knowlton R, Chang EF. PMID: 32944952; PMCID: PMC8139824.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    12. Interictal Epileptiform Discharges and the Quality of Human Intracranial Neurophysiology Data. Front Hum Neurosci. 2020; 14:44. Ammanuel SG, Kleen JK, Leonard MK, Chang EF. PMID: 32194384; PMCID: PMC7062638.
      View in: PubMed   Mentions: 1  
    13. Prospective validation study of an epilepsy seizure risk system for outpatient evaluation. Epilepsia. 2020 01; 61(1):29-38. Chiang S, Goldenholz DM, Moss R, Rao VR, Haneef Z, Theodore WH, Kleen JK, Gavvala J, Vannucci M, Stern JM. PMID: 31792970; PMCID: PMC6980278.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    14. Unsupervised Learning of Spatiotemporal Interictal Discharges in Focal Epilepsy. Neurosurgery. 2018 10 01; 83(4):683-691. Baud MO, Kleen JK, Anumanchipalli GK, Hamilton LS, Tan YL, Knowlton R, Chang EF. PMID: 29040672; PMCID: PMC6454796.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    15. Multi-day rhythms modulate seizure risk in epilepsy. Nat Commun. 2018 01 08; 9(1):88. Baud MO, Kleen JK, Mirro EA, Andrechak JC, King-Stephens D, Chang EF, Rao VR. PMID: 29311566; PMCID: PMC5758806.
      View in: PubMed   Mentions: 164     Fields:    Translation:Humans
    16. The nociferous influence of interictal discharges on memory. Brain. 2017 08 01; 140(8):2072-2074. Kleen JK, Kirsch HE. PMID: 28899025; PMCID: PMC6248646.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    17. Chronic ambulatory electrocorticography from human speech cortex. Neuroimage. 2017 06; 153:273-282. Rao VR, Leonard MK, Kleen JK, Lucas BA, Mirro EA, Chang EF. PMID: 28396294; PMCID: PMC5482367.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    18. Progress in Epilepsy: Latest Waves of Discovery. JAMA Neurol. 2017 02 01; 74(2):139-140. Kleen JK, Lowenstein DH. PMID: 27918766.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    19. Injection Therapy for Headache and Facial Pain. Oral Maxillofac Surg Clin North Am. 2016 Aug; 28(3):423-34. Kleen JK, Levin M. PMID: 27475516.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    20. Oscillation Phase Locking and Late ERP Components of Intracranial Hippocampal Recordings Correlate to Patient Performance in a Working Memory Task. Front Hum Neurosci. 2016; 10:287. Kleen JK, Testorf ME, Roberts DW, Scott RC, Jobst BJ, Holmes GL, Lenck-Santini PP. PMID: 27378885; PMCID: PMC4910536.
      View in: PubMed   Mentions: 10  
    21. Regulatory T cells are not a strong predictor of survival for patients with glioblastoma. Neuro Oncol. 2015 Jun; 17(6):801-9. Thomas AA, Fisher JL, Rahme GJ, Hampton TH, Baron U, Olek S, Schwachula T, Rhodes CH, Gui J, Tafe LJ, Tsongalis GJ, Lefferts JA, Wishart H, Kleen J, Miller M, Whipple CA, de Abreu FB, Ernstoff MS, Fadul CE. PMID: 25618892; PMCID: PMC4483125.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    22. Hippocampal interictal epileptiform activity disrupts cognition in humans. Neurology. 2013 Jul 02; 81(1):18-24. Kleen JK, Scott RC, Holmes GL, Roberts DW, Rundle MM, Testorf M, Lenck-Santini PP, Jobst BC. PMID: 23685931; PMCID: PMC3770206.
      View in: PubMed   Mentions: 113     Fields:    Translation:Humans
    23. Enhanced oscillatory activity in the hippocampal-prefrontal network is related to short-term memory function after early-life seizures. J Neurosci. 2011 Oct 26; 31(43):15397-406. Kleen JK, Wu EX, Holmes GL, Scott RC, Lenck-Santini PP. PMID: 22031886; PMCID: PMC3224083.
      View in: PubMed   Mentions: 35     Fields:    Translation:Animals
    24. Early-life seizures produce lasting alterations in the structure and function of the prefrontal cortex. Epilepsy Behav. 2011 Oct; 22(2):214-9. Kleen JK, Sesqué A, Wu EX, Miller FA, Hernan AE, Holmes GL, Scott RC. PMID: 21873119; PMCID: PMC3185212.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    25. Neuroaminidase reduces interictal spikes in a rat temporal lobe epilepsy model. Epilepsia. 2011 Mar; 52(3):e12-5. Isaev D, Zhao Q, Kleen JK, Lenck-Santini PP, Adstamongkonkul D, Isaeva E, Holmes GL. PMID: 21366554; PMCID: PMC3265164.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    26. Taming TLR4 may ease seizures. Nat Med. 2010 Apr; 16(4):369-70. Kleen JK, Holmes GL. PMID: 20376038.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    27. Hippocampal interictal spikes disrupt cognition in rats. Ann Neurol. 2010 Feb; 67(2):250-7. Kleen JK, Scott RC, Holmes GL, Lenck-Santini PP. PMID: 20225290; PMCID: PMC2926932.
      View in: PubMed   Mentions: 94     Fields:    Translation:Animals
    28. Brain inflammation initiates seizures. Nat Med. 2008 Dec; 14(12):1309-10. Kleen JK, Holmes GL. PMID: 19057551.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    29. Chronic stress impairs spatial memory and motivation for reward without disrupting motor ability and motivation to explore. Behav Neurosci. 2006 Aug; 120(4):842-51. Kleen JK, Sitomer MT, Killeen PR, Conrad CD. PMID: 16893290; PMCID: PMC1578508.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    30. Combination of high fat diet and chronic stress retracts hippocampal dendrites. Neuroreport. 2005 Jan 19; 16(1):39-43. Baran SE, Campbell AM, Kleen JK, Foltz CH, Wright RL, Diamond DM, Conrad CD. PMID: 15618887; PMCID: PMC1363787.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
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