Avi Samelson • UCSF Profiles

Avi Samelson, PhD

Title(s)	Postdoctoral Scholar, Institute for Neurodegenerative Diseases
School	School of Medicine
Address	675 Nelson Rising Lane, #336 San Francisco CA 94158
Pronouns	He/Him/His
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Research

Research Activities and Funding

Mechanisms of tau misfolding in neurons elucidated by deep mutational scanning and CRISPR screening
NIH F32AG063487Jun 17, 2019 - Jun 16, 2022
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions. bioRxiv. 2024 Nov 24. Li E, Benitez C, Boggess SC, Koontz M, Rose IVL, Martinez D, Draeger N, Teter OM, Samelson AJ, Pierce N, Ullian EM, Kampmann M. PMID: 37163077; PMCID: PMC10168378.

View in: PubMed Mentions:
CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis. bioRxiv. 2024 Nov 04. Samelson AJ, Ariqat N, McKetney J, Rohanitazangi G, Bravo CP, Bose R, Travaglini KJ, Lam VL, Goodness D, Dixon G, Marzette E, Jin J, Tian R, Tse E, Abskharon R, Pan H, Carroll EC, Lawrence RE, Gestwicki JE, Eisenberg D, Kanaan NM, Southworth DR, Gross JD, Gan L, Swaney DL, Kampmann M. PMID: 37398204; PMCID: PMC10312804.

View in: PubMed Mentions: 1
The disease-causing tau V337M mutation induces tau hypophosphorylation and perturbs axon morphology pathways. bioRxiv. 2024 Jun 06. Mohl GA, Dixon G, Marzette E, McKetney J, Samelson AJ, Serras CP, Jin J, Li A, Boggess SC, Swaney DL, Kampmann M. PMID: 38895329; PMCID: PMC11185762.

View in: PubMed Mentions:
Human iPSC 4R tauopathy model uncovers modifiers of tau propagation. Cell. 2024 May 09; 187(10):2446-2464.e22. Parra Bravo C, Giani AM, Madero-Perez J, Zhao Z, Wan Y, Samelson AJ, Wong MY, Evangelisti A, Cordes E, Fan L, Ye P, Zhu D, Pozner T, Mercedes M, Patel T, Yarahmady A, Carling GK, Sterky FH, Lee VMY, Lee EB, DeTure M, Dickson DW, Sharma M, Mok SA, Luo W, Zhao M, Kampmann M, Gong S, Gan L. PMID: 38582079; PMCID: PMC11365117.

View in: PubMed Mentions: 9 Fields:
Cel Cell Biology
Translation:Humans Animals Cells
Human iPSC 4R tauopathy model uncovers modifiers of tau propagation. bioRxiv. 2023 Jun 22. Bravo CP, Giani AM, Perez JM, Zhao Z, Samelson A, Wong MY, Evangelisti A, Fan L, Pozner T, Mercedes M, Ye P, Patel T, Yarahmady A, Carling G, Lee VMY, Sharma M, Mok SA, Luo W, Zhao M, Kampmann M, Gong S, Gan L. PMID: 37745431; PMCID: PMC10516028.

View in: PubMed Mentions:
BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2. Nat Cell Biol. 2022 01; 24(1):24-34. Samelson AJ, Tran QD, Robinot R, Carrau L, Rezelj VV, Kain AM, Chen M, Ramadoss GN, Guo X, Lim SA, Lui I, Nuñez JK, Rockwood SJ, Wang J, Liu N, Carlson-Stevermer J, Oki J, Maures T, Holden K, Weissman JS, Wells JA, Conklin BR, TenOever BR, Chakrabarti LA, Vignuzzi M, Tian R, Kampmann M. PMID: 35027731; PMCID: PMC8820466.

View in: PubMed Mentions: 35 Fields:
Cel Cell Biology
Translation:Humans Cells
BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2. bioRxiv. 2021 Sep 20. Samelson AJ, Tran QD, Robinot R, Carrau L, Rezelj VV, Mac Kain A, Chen M, Ramadoss GN, Guo X, Lim SA, Lui I, Nunez J, Rockwood SJ, Wang J, Liu N, Carlson-Stevermer J, Oki J, Maures T, Holden K, Weissman JS, Wells JA, Conklin BR, TenOever BR, Chakrabarti LA, Vignuzzi M, Tian R, Kampmann M. PMID: 33501440; PMCID: PMC7836110.

View in: PubMed Mentions:
Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing. Cell. 2021 04 29; 184(9):2503-2519.e17. Nuñez JK, Chen J, Pommier GC, Cogan JZ, Replogle JM, Adriaens C, Ramadoss GN, Shi Q, Hung KL, Samelson AJ, Pogson AN, Kim JYS, Chung A, Leonetti MD, Chang HY, Kampmann M, Bernstein BE, Hovestadt V, Gilbert LA, Weissman JS. PMID: 33838111; PMCID: PMC8376083.

View in: PubMed Mentions: 242 Fields:
Cel Cell Biology
Translation:Humans Cells
The folding and unfolding behavior of ribonuclease H on the ribosome. J Biol Chem. 2020 08 14; 295(33):11410-11417. Jensen MK, Samelson AJ, Steward A, Clarke J, Marqusee S. PMID: 32527724; PMCID: PMC7450101.

View in: PubMed Mentions: 10 Fields:
Bio Biochemistry
Translation:Cells
Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals. IUCrJ. 2020 Mar 01; 7(Pt 2):306-323. Wolff AM, Young ID, Sierra RG, Brewster AS, Martynowycz MW, Nango E, Sugahara M, Nakane T, Ito K, Aquila A, Bhowmick A, Biel JT, Carbajo S, Cohen AE, Cortez S, Gonzalez A, Hino T, Im D, Koralek JD, Kubo M, Lazarou TS, Nomura T, Owada S, Samelson AJ, Tanaka T, Tanaka R, Thompson EM, van den Bedem H, Woldeyes RA, Yumoto F, Zhao W, Tono K, Boutet S, Iwata S, Gonen T, Sauter NK, Fraser JS, Thompson MC. PMID: 32148858; PMCID: PMC7055375.

View in: PubMed Mentions: 19 Fields:
Che Chemistry
Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex. Science. 2019 11 22; 366(6468):971-977. Lawrence RE, Fromm SA, Fu Y, Yokom AL, Kim DJ, Thelen AM, Young LN, Lim CY, Samelson AJ, Hurley JH, Zoncu R. PMID: 31672913; PMCID: PMC6945816.

View in: PubMed Mentions: 82 Fields:
Sci Science
Translation:Humans Cells
Kinetic and structural comparison of a protein's cotranslational folding and refolding pathways. Sci Adv. 2018 05; 4(5):eaas9098. Samelson AJ, Bolin E, Costello SM, Sharma AK, O'Brien EP, Marqusee S. PMID: 29854950; PMCID: PMC5976279.

View in: PubMed Mentions: 23 Fields:
Sci Science
Translation:Cells
Quantitative determination of ribosome nascent chain stability. Proc Natl Acad Sci U S A. 2016 11 22; 113(47):13402-13407. Samelson AJ, Jensen MK, Soto RA, Cate JH, Marqusee S. PMID: 27821780; PMCID: PMC5127326.

View in: PubMed Mentions: 47 Fields:
Sci Science
Translation:Cells
HIV-1 Tat recruits transcription elongation factors dispersed along a flexible AFF4 scaffold. Proc Natl Acad Sci U S A. 2013 Jan 08; 110(2):E123-31. Chou S, Upton H, Bao K, Schulze-Gahmen U, Samelson AJ, He N, Nowak A, Lu H, Krogan NJ, Zhou Q, Alber T. PMID: 23251033; PMCID: PMC3545800.

View in: PubMed Mentions: 50 Fields:
Sci Science
Translation:Humans Cells
Accessing protein conformational ensembles using room-temperature X-ray crystallography. Proc Natl Acad Sci U S A. 2011 Sep 27; 108(39):16247-52. Fraser JS, van den Bedem H, Samelson AJ, Lang PT, Holton JM, Echols N, Alber T. PMID: 21918110; PMCID: PMC3182744.

View in: PubMed Mentions: 305 Fields:
Sci Science
Translation:Cells