Claude Chapman, PhD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address513 Parnassus Ave, HSE, #201
San Francisco CA 94143
ORCID ORCID Icon0000-0002-6041-2870 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Universite de Provence, Marseille, FranceBS06/1989Biochemistry and Microbiology
    Universite de Provence, Marseille, FranceMS06/1990Cell and Molecular Biology
    Universite de Provence, Marseille, FranceMENG09/1991Microbiology and Biotechnology
    Universite de Provence , Marseille, France PhD10/1996Cell and Molecular Biolog
    Collapse Awards and Honors
    17th colloquium on lung and airways fibrosis, Modena, Italy2012Young investigator award
    American Thoracic Society Respiratory Cell and Molecular Biology2014Carol Basbaum Award

    Collapse Overview 
    Collapse Overview
    While dysfunctional alveolar epithelial cells type II (AECII) are thought to be central to the initiation of IPF, the mechanisms by which AECIIs provoke fibrosis are uncertain. Independent studies have shown that markers of cellular senescence (p53, p21, and p16INK4A) are upregulated in AECIIs in IPF lungs within the remodeled fibrotic areas. Despite the detection of senescent AECIIs in fibrotic lungs, their role in fibrogenesis is unknown and their secretory phenotype (SASP) remains undefined. In addition, senescent fibroblasts have also been detected in pulmonary fibrotic tissue. Interestingly, unlike many organs where the fibrosis never resolves, dermal fibrosis can undergo spontaneous regression despite the constant detection of senescent fibroblasts. We, therefore, hypothesize that the dynamic changes in the SASP from profibrotic to pro-resolution occurs in skin but not in lungs resulting in fibrosis reversal only in the skin. Using transgenic mouse strains and pharmacological senolytic treatment, we will determine how Sn cells have the potential to regulate fibrogenesis and its resolution by switching their SASP factors expression over time. Our findings will have important implications for how emerging senolytic drugs, which have the potential to provide novel therapeutic benefits for the treatment of SSc, should best be administered.

    Collapse Research 
    Collapse Research Activities and Funding
    Characterization of the Various Senescent Cells in the Aging Lungs
    NIH R21AG052744Jun 1, 2016 - Mar 31, 2019
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Human Fetal Tissue Regulation. Impact on Pediatric and Adult Respiratory-related Research. Ann Am Thorac Soc. 2021 02; 18(2):204-208. Al Alam D, Ballard PL, Jourdan Le Saux C, Ingram JL, Mariani TJ, Moore NS, Weiss DJ, Yu M. PMID: 33252996.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    2. Blocking LOXL2 and TGFβ1 signalling induces collagen I turnover in precision-cut lung slices derived from patients with idiopathic pulmonary fibrosis. Thorax. 2021 07; 76(7):729-732. Wei Y, Dong W, Jackson J, Ho TC, Le Saux CJ, Brumwell A, Li X, Klesney-Tait J, Cohen ML, Wolters PJ, Chapman HA. . PMID: 33472968; PMCID: PMC8222054.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    3. Age-dependent regulation of cell-mediated collagen turnover. JCI Insight. 2020 05 21; 5(10). Podolsky MJ, Yang CD, Valenzuela CL, Datta R, Huang SK, Nishimura SL, Dallas SL, Wolters PJ, Le Saux CJ, Atabai K. PMID: 32315288; PMCID: PMC7259530.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    4. Interleukin 17 and senescent cells regulate the foreign body response to synthetic material implants in mice and humans. Sci Transl Med. 2020 04 15; 12(539). Chung L, Maestas DR, Lebid A, Mageau A, Rosson GD, Wu X, Wolf MT, Tam AJ, Vanderzee I, Wang X, Andorko JI, Zhang H, Narain R, Sadtler K, Fan H, Ciháková D, Le Saux CJ, Housseau F, Pardoll DM, Elisseeff JH. PMID: 32295900; PMCID: PMC7219543.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimals
    5. Reversal of TGFβ1-Driven Profibrotic State in Patients with Pulmonary Fibrosis. N Engl J Med. 2020 03 12; 382(11):1068-1070. Chapman HA, Wei Y, Montas G, Leong D, Golden JA, Trinh BN, Wolters PJ, Le Saux CJ, Jones KD, Hills NK, Foster E, Oldham JM, Linderholm AL, Kotak P, Decaris M, Turner S, Song JW. PMID: 32160670; PMCID: PMC7297220.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    6. Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis. JCI Insight. 2019 12 19; 4(24). Wiley CD, Brumwell AN, Davis SS, Jackson JR, Valdovinos A, Calhoun C, Alimirah F, Castellanos CA, Ruan R, Wei Y, Chapman HA, Ramanathan A, Campisi J, Jourdan Le Saux C. PMID: 31687975; PMCID: PMC6975274.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    7. Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition. Nat Commun. 2019 06 03; 10(1):2387. Pereira BI, Devine OP, Vukmanovic-Stejic M, Chambers ES, Subramanian P, Patel N, Virasami A, Sebire NJ, Kinsler V, Valdovinos A, LeSaux CJ, Passos JF, Antoniou A, Rustin MHA, Campisi J, Akbar AN. PMID: 31160572; PMCID: PMC6547655.
      View in: PubMed   Mentions: 167     Fields:    Translation:HumansCells
    8. Idiopathic Pulmonary Fibrosis: Cell Death and Inflammation Revisited. Am J Respir Cell Mol Biol. 2018 08; 59(2):137-138. Le Saux CJ, Chapman HA. . PMID: 29698615.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    9. Fibroblast-specific inhibition of TGF-β1 signaling attenuates lung and tumor fibrosis. J Clin Invest. 2017 Oct 02; 127(10):3675-3688. Wei Y, Kim TJ, Peng DH, Duan D, Gibbons DL, Yamauchi M, Jackson JR, Le Saux CJ, Calhoun C, Peters J, Derynck R, Backes BJ, Chapman HA. . PMID: 28872461; PMCID: PMC5617667.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    10. Differences in forward angular light scattering distributions between M1 and M2 macrophages. J Biomed Opt. 2015 Nov; 20(11):115002. Halaney DL, Zahedivash A, Phipps JE, Wang T, Dwelle J, Saux CJ, Asmis R, Milner TE, Feldman MD. PMID: 26538329; PMCID: PMC4881287.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    11. Calpastatin overexpression impairs postinfarct scar healing in mice by compromising reparative immune cell recruitment and activation. Am J Physiol Heart Circ Physiol. 2015 Dec 01; 309(11):H1883-93. Wan F, Letavernier E, Le Saux CJ, Houssaini A, Abid S, Czibik G, Sawaki D, Marcos E, Dubois-Rande JL, Baud L, Adnot S, Derumeaux G, Gellen B. PMID: 26453333.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    12. Women and Lung Disease. Sex Differences and Global Health Disparities. Am J Respir Crit Care Med. 2015 Jul 01; 192(1):11-6. Pinkerton KE, Harbaugh M, Han MK, Jourdan Le Saux C, Van Winkle LS, Martin WJ, Kosgei RJ, Carter EJ, Sitkin N, Smiley-Jewell SM, George M. PMID: 25945507; PMCID: PMC4511423.
      View in: PubMed   Mentions: 52     Fields:    Translation:Humans
    13. Myocardial tissue caveolae. Compr Physiol. 2015 Apr; 5(2):871-86. Sanon VP, Sawaki D, Mjaatvedt CH, Jourdan-Le Saux C. PMID: 25880516.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    14. SMAD-independent down-regulation of caveolin-1 by TGF-β: effects on proliferation and survival of myofibroblasts. PLoS One. 2015; 10(2):e0116995. Sanders YY, Cui Z, Le Saux CJ, Horowitz JC, Rangarajan S, Kurundkar A, Antony VB, Thannickal VJ. PMID: 25658089; PMCID: PMC4319960.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    15. Senescent Cells Contribute to the Physiological Remodeling of Aged Lungs. J Gerontol A Biol Sci Med Sci. 2016 Feb; 71(2):153-60. Calhoun C, Shivshankar P, Saker M, Sloane LB, Livi CB, Sharp ZD, Orihuela CJ, Adnot S, White ES, Richardson A, Le Saux CJ. PMID: 25568097; PMCID: PMC4861645.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    16. Streptococcus pneumoniae translocates into the myocardium and forms unique microlesions that disrupt cardiac function. PLoS Pathog. 2014 Sep; 10(9):e1004383. Brown AO, Mann B, Gao G, Hankins JS, Humann J, Giardina J, Faverio P, Restrepo MI, Halade GV, Mortensen EM, Lindsey ML, Hanes M, Happel KI, Nelson S, Bagby GJ, Lorent JA, Cardinal P, Granados R, Esteban A, LeSaux CJ, Tuomanen EI, Orihuela CJ. PMID: 25232870; PMCID: PMC4169480.
      View in: PubMed   Mentions: 94     Fields:    Translation:AnimalsCellsPHPublic Health
    17. Caveolin-1 deletion exacerbates cardiac interstitial fibrosis by promoting M2 macrophage activation in mice after myocardial infarction. J Mol Cell Cardiol. 2014 Nov; 76:84-93. Shivshankar P, Halade GV, Calhoun C, Escobar GP, Mehr AJ, Jimenez F, Martinez C, Bhatnagar H, Mjaatvedt CH, Lindsey ML, Le Saux CJ. PMID: 25128086; PMCID: PMC4533121.
      View in: PubMed   Mentions: 47     Fields:    Translation:Animals
    18. Mycoplasma pneumoniae CARDS toxin exacerbates ovalbumin-induced asthma-like inflammation in BALB/c mice. PLoS One. 2014; 9(7):e102613. Medina JL, Coalson JJ, Brooks EG, Le Saux CJ, Winter VT, Chaparro A, Principe MF, Solis L, Kannan TR, Baseman JB, Dube PH. PMID: 25058417; PMCID: PMC4109942.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    19. Role of caveolin-1 in asthma and chronic inflammatory respiratory diseases. Expert Rev Respir Med. 2014 Jun; 8(3):339-47. Royce SG, Le Saux CJ. PMID: 24742020.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    20. Colony-stimulating factor 1 potentiates lung cancer bone metastasis. Lab Invest. 2014 Apr; 94(4):371-81. Hung JY, Horn D, Woodruff K, Prihoda T, LeSaux C, Peters J, Tio F, Abboud-Werner SL. PMID: 24468794.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    21. Airway hyperresponsiveness is associated with airway remodeling but not inflammation in aging Cav1-/- mice. Respir Res. 2013 Oct 21; 14:110. Gabehart KE, Royce SG, Maselli DJ, Miyasato SK, Davis EC, Tang ML, Jourdan Le Saux C. PMID: 24138138; PMCID: PMC4015038.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    22. A novel telomerase activator suppresses lung damage in a murine model of idiopathic pulmonary fibrosis. PLoS One. 2013; 8(3):e58423. Le Saux CJ, Davy P, Brampton C, Ahuja SS, Fauce S, Shivshankar P, Nguyen H, Ramaseshan M, Tressler R, Pirot Z, Harley CB, Allsopp R. PMID: 23516479; PMCID: PMC3597721.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    23. Chronic and intermittent hypoxia differentially regulate left ventricular inflammatory and extracellular matrix responses. Hypertens Res. 2012 Aug; 35(8):811-8. Ramirez TA, Jourdan-Le Saux C, Joy A, Zhang J, Dai Q, Mifflin S, Lindsey ML. PMID: 22495609; PMCID: PMC3419973.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    24. Caveolin-1 deficiency protects from pulmonary fibrosis by modulating epithelial cell senescence in mice. Am J Respir Cell Mol Biol. 2012 Jul; 47(1):28-36. Shivshankar P, Brampton C, Miyasato S, Kasper M, Thannickal VJ, Le Saux CJ. PMID: 22362388; PMCID: PMC3402795.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    25. Cellular senescence increases expression of bacterial ligands in the lungs and is positively correlated with increased susceptibility to pneumococcal pneumonia. Aging Cell. 2011 Oct; 10(5):798-806. Shivshankar P, Boyd AR, Le Saux CJ, Yeh IT, Orihuela CJ. PMID: 21615674; PMCID: PMC3173515.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    26. Caveolin-1 modulates TGF-β1 signaling in cardiac remodeling. Matrix Biol. 2011 Jun; 30(5-6):318-29. Miyasato SK, Loeffler J, Shohet R, Zhang J, Lindsey M, Le Saux CJ. PMID: 21641995; PMCID: PMC4489541.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    27. Extracellular matrix roles during cardiac repair. Life Sci. 2010 Sep 25; 87(13-14):391-400. Jourdan-Lesaux C, Zhang J, Lindsey ML. PMID: 20670633; PMCID: PMC2946433.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    28. The role of caveolin-1 in pulmonary matrix remodeling and mechanical properties. Am J Physiol Lung Cell Mol Physiol. 2008 Dec; 295(6):L1007-17. Le Saux O, Teeters K, Miyasato S, Choi J, Nakamatsu G, Richardson JA, Starcher B, Davis EC, Tam EK, Jourdan-Le Saux C. PMID: 18849439; PMCID: PMC2604793.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    29. Down-regulation of caveolin-1, an inhibitor of transforming growth factor-beta signaling, in acute allergen-induced airway remodeling. J Biol Chem. 2008 Feb 29; 283(9):5760-8. Le Saux CJ, Teeters K, Miyasato SK, Hoffmann PR, Bollt O, Douet V, Shohet RV, Broide DH, Tam EK. PMID: 18056268.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    30. A role for dietary selenium and selenoproteins in allergic airway inflammation. J Immunol. 2007 Sep 01; 179(5):3258-67. Hoffmann PR, Jourdan-Le Saux C, Hoffmann FW, Chang PS, Bollt O, He Q, Tam EK, Berry MJ. PMID: 17709542.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    31. A new approach for analyzing cellular infiltration during allergic airway inflammation. J Immunol Methods. 2007 Dec 01; 328(1-2):21-33. Hoffmann PR, Gurary A, Hoffmann FW, Jourdan-Le Saux C, Teeters K, Hashimoto AC, Tam EK, Berry MJ. PMID: 17825315; PMCID: PMC2864229.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    32. Oral health disparities and periodontal disease in Asian and Pacific Island populations. Ethn Dis. 2005; 15(4 Suppl 5):S5-39-46. Harrigan RC, Easa D, LeSaux C, Millar L, Kagihara LE, Shomaker TS, Greer MH, Beck JD, Offenbacher S. PMID: 16315381; PMCID: PMC1469774.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    33. Progressive hair loss and myocardial degeneration in rough coat mice: reduced lysyl oxidase-like (LOXL) in the skin and heart. J Invest Dermatol. 2004 Nov; 123(5):864-71. Hayashi K, Cao T, Passmore H, Jourdan-Le Saux C, Fogelgren B, Khan S, Hornstra I, Kim Y, Hayashi M, Csiszar K. PMID: 15482472.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    34. Polymorphisms in the interleukin-4 receptor alpha chain: association with traits of allergy and asthma in an admixed population in Hawaii. Cell Mol Biol (Noisy-le-grand). 2003 Dec; 49(8):1345-9. Tam EK, Jourdan-LeSaux C, Stauder S, Bollt O, Reber B, Yamamoto F, Haymer D. PMID: 14984008.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    35. A base substitution in the interleukin-10 (IL-10) promoter between Sp1 and ets-1 binding sites is not associated with variation of IL-10 levels. Cell Mol Biol (Noisy-le-grand). 2003 Nov; 49(7):1109-15. Jourdan-Le Saux C, Bollt O, Orozco C, Concepcion J, Yamaga K, Yamamoto F, Haymer D, Tam EK. PMID: 14682393.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    36. Report of the first annual Hawaii Asthma Research Consortium. Hawaii Med J. 2002 Sep; 61(9):194-8. Chan DS, Callahan CW, Beckham S, Kishaba G, Yamamoto K, Malone FJ, Boychuk R, Tam E, Jourdan-Lesaux C, Underwood G, Vogt TM, Takafuji E. PMID: 12422384.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    37. Immunohistochemical localization of Pax2 and associated proteins in the developing kidney of mice with renal hypoplasia. J Histochem Cytochem. 2001 Sep; 49(9):1081-97. Lozanoff S, Johnston J, Ma W, Jourdan-Le Saux C. PMID: 11511678.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    38. Central nervous system, uterus, heart, and leukocyte expression of the LOXL3 gene, encoding a novel lysyl oxidase-like protein. Genomics. 2001 Jun 01; 74(2):211-8. Jourdan-Le Saux C, Tomsche A, Ujfalusi A, Jia L, Csiszar K. PMID: 11386757.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    39. Lysyl oxidases: expression in the fetal membranes and placenta. Placenta. 2001 Jan; 22(1):49-57. Hein S, Yamamoto SY, Okazaki K, Jourdan-LeSaux C, Csiszar K, Bryant-Greenwood GD. PMID: 11162352.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    40. The mouse lysyl oxidase-like 2 gene (mLOXL2) maps to chromosome 14 and is highly expressed in skin, lung and thymus. Matrix Biol. 2000 May; 19(2):179-83. Jourdan-Le Saux C, Le Saux O, Gleyzal C, Sommer P, Csiszar K. PMID: 10842102.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    41. Comparative functional study of the lysyl oxidase promoter in fibroblasts, Ras-transformed fibroblasts, myofibroblasts and smooth muscle cells. Cell Mol Biol (Noisy-le-grand). 1999 Dec; 45(8):1237-47. Reynaud C, Gleyzal C, Jourdan-Le Saux C, Sommer P. PMID: 10643973.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    42. The LOXL2 gene encodes a new lysyl oxidase-like protein and is expressed at high levels in reproductive tissues. J Biol Chem. 1999 Apr 30; 274(18):12939-44. Jourdan-Le Saux C, Tronecker H, Bogic L, Bryant-Greenwood GD, Boyd CD, Csiszar K. PMID: 10212285.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    43. The human lysyl oxidase-related gene (LOXL2) maps between markers D8S280 and D8S278 on chromosome 8p21.2-p21.3. Genomics. 1998 Jul 15; 51(2):305-7. Jourdan-Le Saux C, Le Saux O, Donlon T, Boyd CD, Csiszar K. PMID: 9722957.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    44. Functional analysis of the lysyl oxidase promoter in myofibroblast-like clones of 3T6 fibroblast. J Cell Biochem. 1997 Feb; 64(2):328-41. Jourdan-Le Saux C, Gleyzal C, Raccurt M, Sommer P. PMID: 9027591.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    45. Lysyl oxidase cDNA of myofibroblast from mouse fibrotic liver. Biochem Biophys Res Commun. 1994 Mar 15; 199(2):587-92. Jourdan-Le Saux C, Gleyzal C, Garnier JM, Peraldi M, Sommer P, Grimaud JA. PMID: 7510957.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    46. Rapid mycobacterial plasmid analysis by electroduction between Mycobacterium spp. and Escherichia coli. Nucleic Acids Res. 1992 Aug 11; 20(15):4105. Baulard A, Jourdan C, Mercenier A, Locht C. PMID: 1508702; PMCID: PMC334105.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
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