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Stephen Nishimura, MD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentPathology
Address1001 Potrero Ave
San Francisco CA 94110
Phone415-206-5906
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency School of Medicine

    Collapse Research 
    Collapse Research Activities and Funding
    Structural mechanism of integrin-mediated TGF-b activation
    NIH/NHLBI R01HL134183Jul 4, 2016 - Apr 30, 2020
    Role: Co-Principal Investigator
    Role of genetic variation in TGF-beta overactivation in COPD
    NIH/NHLBI R01HL113032Apr 1, 2012 - Mar 31, 2016
    Role: Principal Investigator
    Role of Squamous Metaplasia in Small Airways Disease in COPD
    NIH/NHLBI R01HL090662Sep 1, 2009 - Aug 31, 2011
    Role: Principal Investigator
    Integrin Regulation of Airway Epithelial Proliferation
    NIH/NHLBI K02HL070622Aug 1, 2002 - Jul 31, 2007
    Role: Principal Investigator
    Integrative Study of Brain Vascular Malformations
    NIH/NINDS P01NS044155Jul 1, 2002 - Mar 31, 2014
    Role: Co-Investigator
    Integrin alphavbeta8 Inhibits Airway Epithelial Cell Growth
    NIH/NHLBI R01HL063993Dec 1, 1999 - Mar 31, 2013
    Role: Principal Investigator
    DISTRIBUTION AND FUNCTION OF THE INTEGRIN ANDYB8
    NIH/NCI K08CA063148Jul 1, 1995 - Jun 30, 2001
    Role: Principal Investigator
    INTEGRINS AND BLASTOCYST-ENDOMETRIAL INTERACTION
    NIH/NCI F32CA009335Feb 10, 1993
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Yanagisawa H, Hashimoto M, Minagawa S, Takasaka N, Ma R, Moermans C, Ito S, Araya J, Budelsky A, Goodsell A, Baron JL, Nishimura S. Role of IL-17A in murine models of COPD airway disease. Am J Physiol Lung Cell Mol Physiol. 2016 Dec 02; ajplung.00301.2016. PMID: 27913421.
      View in: PubMed
    2. Ma L, Shen F, Jun K, Bao C, Kuo R, Young WL, Nishimura S, Su H. Integrin ß8 Deletion Enhances Vascular Dysplasia and Hemorrhage in the Brain of Adult Alk1 Heterozygous Mice. Transl Stroke Res. 2016 Dec; 7(6):488-496. PMID: 27352867.
      View in: PubMed
    3. Publicover J, Jespersen JM, Johnson AJ, Nishimura S, Goodsell A, Wakil AE, Rosenthal P, Pai E, Avanesyan L, Cooper S, Baron JL. Liver capsule: Age-influenced hepatic immune priming determines HBV infection fate: Implications from mouse to man. Hepatology. 2016 Jan; 63(1):260. PMID: 26457468.
      View in: PubMed
    4. Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Ma R, Murray LA, Tsui P, Lou J, Marks JD, Baron JL, Krummel MF, Nishimura S. TGF-ß-Dependent Dendritic Cell Chemokinesis in Murine Models of Airway Disease. J Immunol. 2015 Aug 1; 195(3):1182-90. PMID: 26109638; PMCID: PMC4506848 [Available on 08/01/16].
      View in: PubMed, PubMed Central
    5. Brand OJ, Somanath S, Moermans C, Yanagisawa H, Hashimoto M, Cambier S, Markovics J, Bondesson AJ, Hill A, Jablons D, Wolters P, Lou J, Marks JD, Baron JL, Nishimura S. Transforming Growth Factor-ß and Interleukin-1ß Signaling Pathways Converge on the Chemokine CCL20 Promoter. J Biol Chem. 2015 Jun 5; 290(23):14717-28. PMID: 25918170; PMCID: PMC4505537 [Available on 06/05/16].
      View in: PubMed, PubMed Central
    6. Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Goodsell A, Ma R, Moermans C, McKnelly KJ, Baron JL, Krummel MF, Nishimura S. A critical role for dendritic cells in the evolution of IL-1ß-mediated murine airway disease. J Immunol. 2015 Apr 15; 194(8):3962-9. PMID: 25786688; PMCID: PMC4390519 [Available on 04/15/16].
      View in: PubMed, PubMed Central
    7. Ito S, Araya J, Kurita Y, Kobayashi K, Takasaka N, Yoshida M, Hara H, Minagawa S, Wakui H, Fujii S, Kojima J, Shimizu K, Numata T, Kawaishi M, Odaka M, Morikawa T, Harada T, Nishimura S, Kaneko Y, Nakayama K, Kuwano K. PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis. Autophagy. 2015; 11(3):547-59. PMID: 25714760; PMCID: PMC4502689 [Available on 02/25/16].
      View in: PubMed, PubMed Central
    8. Minagawa S, Lou J, Seed RI, Cormier A, Wu S, Cheng Y, Murray L, Tsui P, Connor J, Herbst R, Govaerts C, Barker T, Cambier S, Yanagisawa H, Goodsell A, Hashimoto M, Brand OJ, Cheng R, Ma R, McKnelly KJ, Wen W, Hill A, Jablons D, Wolters P, Kitamura H, Araya J, Barczak AJ, Erle DJ, Reichardt LF, Marks JD, Baron JL, Nishimura S. Selective targeting of TGF-ß activation to treat fibroinflammatory airway disease. Sci Transl Med. 2014 Jun 18; 6(241):241ra79. PMID: 24944194; PMCID: PMC4341974.
      View in: PubMed, PubMed Central
    9. Wu TC, Xu K, Banchereau R, Marches F, Yu CI, Martinek J, Anguiano E, Pedroza-Gonzalez A, Snipes GJ, O'Shaughnessy J, Nishimura S, Liu YJ, Pascual V, Banchereau J, Oh S, Palucka K. Reprogramming tumor-infiltrating dendritic cells for CD103+ CD8+ mucosal T-cell differentiation and breast cancer rejection. Cancer Immunol Res. 2014 May; 2(5):487-500. PMID: 24795361; PMCID: PMC4014008.
      View in: PubMed, PubMed Central
    10. Lee TH, McKleroy W, Khalifeh-Soltani A, Sakuma S, Lazarev S, Riento K, Nishimura S, Nichols BJ, Atabai K. Functional genomic screen identifies novel mediators of collagen uptake. Mol Biol Cell. 2014 Mar; 25(5):583-93. PMID: 24403604; PMCID: PMC3937085.
      View in: PubMed, PubMed Central
    11. Takasaka N, Araya J, Hara H, Ito S, Kobayashi K, Kurita Y, Wakui H, Yoshii Y, Yumino Y, Fujii S, Minagawa S, Tsurushige C, Kojima J, Numata T, Shimizu K, Kawaishi M, Kaneko Y, Kamiya N, Hirano J, Odaka M, Morikawa T, Nishimura S, Nakayama K, Kuwano K. Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence. J Immunol. 2014 Feb 1; 192(3):958-68. PMID: 24367027.
      View in: PubMed
    12. Publicover J, Gaggar A, Nishimura S, Van Horn CM, Goodsell A, Muench MO, Reinhardt RL, van Rooijen N, Wakil AE, Peters M, Cyster JG, Erle DJ, Rosenthal P, Cooper S, Baron JL. Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B. J Clin Invest. 2013 Sep; 123(9):3728-39. PMID: 23925290; PMCID: PMC3754256.
      View in: PubMed, PubMed Central
    13. Araya J, Kojima J, Takasaka N, Ito S, Fujii S, Hara H, Yanagisawa H, Kobayashi K, Tsurushige C, Kawaishi M, Kamiya N, Hirano J, Odaka M, Morikawa T, Nishimura S, Kawabata Y, Hano H, Nakayama K, Kuwano K. Insufficient autophagy in idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2013 Jan 1; 304(1):L56-69. PMID: 23087019.
      View in: PubMed
    14. Markovics JA, Araya J, Cambier S, Somanath S, Gline S, Jablons D, Hill A, Wolters PJ, Nishimura S. Interleukin-1beta induces increased transcriptional activation of the transforming growth factor-beta-activating integrin subunit beta8 through altering chromatin architecture. J Biol Chem. 2011 Oct 21; 286(42):36864-74. PMID: 21878622; PMCID: PMC3196125.
      View in: PubMed, PubMed Central
    15. Kitamura H, Cambier S, Somanath S, Barker T, Minagawa S, Markovics J, Goodsell A, Publicover J, Reichardt L, Jablons D, Wolters P, Hill A, Marks JD, Lou J, Pittet JF, Gauldie J, Baron JL, Nishimura S. Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin avß8-mediated activation of TGF-ß. J Clin Invest. 2011 Jul; 121(7):2863-75. PMID: 21646718; PMCID: PMC3223836.
      View in: PubMed, PubMed Central
    16. Numata T, Araya J, Fujii S, Hara H, Takasaka N, Kojima J, Minagawa S, Yumino Y, Kawaishi M, Hirano J, Odaka M, Morikawa T, Nishimura S, Nakayama K, Kuwano K. Insulin-dependent phosphatidylinositol 3-kinase/Akt and ERK signaling pathways inhibit TLR3-mediated human bronchial epithelial cell apoptosis. J Immunol. 2011 Jul 1; 187(1):510-9. PMID: 21646299.
      View in: PubMed
    17. Publicover J, Goodsell A, Nishimura S, Vilarinho S, Wang ZE, Avanesyan L, Spolski R, Leonard WJ, Cooper S, Baron JL. IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B. J Clin Invest. 2011 Mar; 121(3):1154-62. PMID: 21393863; PMCID: PMC3049376.
      View in: PubMed, PubMed Central
    18. Minagawa S, Araya J, Numata T, Nojiri S, Hara H, Yumino Y, Kawaishi M, Odaka M, Morikawa T, Nishimura S, Nakayama K, Kuwano K. Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-ß-induced senescence of human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2011 Mar; 300(3):L391-401. PMID: 21224216; PMCID: PMC3284316.
      View in: PubMed, PubMed Central
    19. Markovics JA, Araya J, Cambier S, Jablons D, Hill A, Wolters PJ, Nishimura S. Transcription of the transforming growth factor beta activating integrin beta8 subunit is regulated by SP3, AP-1, and the p38 pathway. J Biol Chem. 2010 Aug 6; 285(32):24695-706. PMID: 20519498; PMCID: PMC2915706.
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    20. Arjomandi M, Seward J, Gotway MB, Nishimura S, Fulton GP, Thundiyil J, King TE, Harber P, Balmes JR. Low prevalence of chronic beryllium disease among workers at a nuclear weapons research and development facility. J Occup Environ Med. 2010 Jun; 52(6):647-52. PMID: 20523233; PMCID: PMC3313491.
      View in: PubMed, PubMed Central
    21. Araya J, Nishimura S. Fibrogenic reactions in lung disease. Annu Rev Pathol. 2010; 5:77-98. PMID: 20078216.
      View in: PubMed
    22. Su H, Kim H, Pawlikowska L, Kitamura H, Shen F, Cambier S, Markovics J, Lawton MT, Sidney S, Bollen AW, Kwok PY, Reichardt L, Young WL, Yang GY, Nishimura S. Reduced expression of integrin alphavbeta8 is associated with brain arteriovenous malformation pathogenesis. Am J Pathol. 2010 Feb; 176(2):1018-27. PMID: 20019187; PMCID: PMC2808104.
      View in: PubMed, PubMed Central
    23. Chesnokova LS, Nishimura S, Hutt-Fletcher LM. Fusion of epithelial cells by Epstein-Barr virus proteins is triggered by binding of viral glycoproteins gHgL to integrins alphavbeta6 or alphavbeta8. Proc Natl Acad Sci U S A. 2009 Dec 1; 106(48):20464-9. PMID: 19920174; PMCID: PMC2787161.
      View in: PubMed, PubMed Central
    24. Nishimura S. Integrin-mediated transforming growth factor-beta activation, a potential therapeutic target in fibrogenic disorders. Am J Pathol. 2009 Oct; 175(4):1362-70. PMID: 19729474; PMCID: PMC2751532.
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    25. Zhu Y, Cuevas IC, Gabriel RA, Su H, Nishimura S, Gao P, Fields A, Hao Q, Young WL, Yang GY, Boudreau NJ. Restoring transcription factor HoxA5 expression inhibits the growth of experimental hemangiomas in the brain. J Neuropathol Exp Neurol. 2009 Jun; 68(6):626-32. PMID: 19458547; PMCID: PMC2728585.
      View in: PubMed, PubMed Central
    26. Wilson SM, Barbone D, Yang TM, Jablons DM, Bueno R, Sugarbaker DJ, Nishimura S, Gordon GJ, Broaddus VC. mTOR mediates survival signals in malignant mesothelioma grown as tumor fragment spheroids. Am J Respir Cell Mol Biol. 2008 Nov; 39(5):576-83. PMID: 18511708; PMCID: PMC2574528.
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    27. An F, Drummond DC, Wilson S, Kirpotin DB, Nishimura S, Broaddus VC, Liu B. Targeted drug delivery to mesothelioma cells using functionally selected internalizing human single-chain antibodies. Mol Cancer Ther. 2008 Mar; 7(3):569-78. PMID: 18319332; PMCID: PMC2943512.
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    28. Vilarinho S, Ogasawara K, Nishimura S, Lanier LL, Baron JL. Blockade of NKG2D on NKT cells prevents hepatitis and the acute immune response to hepatitis B virus. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):18187-92. PMID: 17991774; PMCID: PMC2084318.
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    29. Araya J, Cambier S, Markovics JA, Wolters P, Jablons D, Hill A, Finkbeiner W, Jones K, Broaddus VC, Sheppard D, Barzcak A, Xiao Y, Erle DJ, Nishimura S. Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients. J Clin Invest. 2007 Nov; 117(11):3551-62. PMID: 17965775; PMCID: PMC2040320.
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    30. Araya J, Cambier S, Morris A, Finkbeiner W, Nishimura S. Integrin-mediated transforming growth factor-beta activation regulates homeostasis of the pulmonary epithelial-mesenchymal trophic unit. Am J Pathol. 2006 Aug; 169(2):405-15. PMID: 16877343; PMCID: PMC1698780.
      View in: PubMed, PubMed Central
    31. Diaz JV, Koff J, Gotway MB, Nishimura S, Balmes JR. Case report: a case of wood-smoke-related pulmonary disease. Environ Health Perspect. 2006 May; 114(5):759-62. PMID: 16675433; PMCID: PMC1459932.
      View in: PubMed, PubMed Central
    32. Neurohr C, Nishimura S, Sheppard D. Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure. Am J Respir Cell Mol Biol. 2006 Aug; 35(2):252-9. PMID: 16574941; PMCID: PMC2643260.
      View in: PubMed, PubMed Central
    33. Kim KU, Wilson SM, Abayasiriwardana KS, Collins R, Fjellbirkeland L, Xu Z, Jablons DM, Nishimura S, Broaddus VC. A novel in vitro model of human mesothelioma for studying tumor biology and apoptotic resistance. Am J Respir Cell Mol Biol. 2005 Dec; 33(6):541-8. PMID: 16123394; PMCID: PMC2715331.
      View in: PubMed, PubMed Central
    34. Cambier S, Gline S, Mu D, Collins R, Araya J, Dolganov G, Einheber S, Boudreau N, Nishimura S. Integrin alpha(v)beta8-mediated activation of transforming growth factor-beta by perivascular astrocytes: an angiogenic control switch. Am J Pathol. 2005 Jun; 166(6):1883-94. PMID: 15920172; PMCID: PMC1602409.
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    35. Gline SE, Cambier S, Govaerts C, Nishimura S. A 50-A separation of the integrin alpha v beta 3 extracellular domain C termini reveals an intermediate activation state. J Biol Chem. 2004 Dec 24; 279(52):54567-72. PMID: 15475365.
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    36. Jackson T, Clark S, Berryman S, Burman A, Cambier S, Mu D, Nishimura S, King AM. Integrin alphavbeta8 functions as a receptor for foot-and-mouth disease virus: role of the beta-chain cytodomain in integrin-mediated infection. J Virol. 2004 May; 78(9):4533-40. PMID: 15078934; PMCID: PMC387692.
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    37. Morris DG, Jasmer RM, Huang L, Gotway MB, Nishimura S, King TE. Sarcoidosis following HIV infection: evidence for CD4+ lymphocyte dependence. Chest. 2003 Sep; 124(3):929-35. PMID: 12970019.
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    38. Fjellbirkeland L, Cambier S, Broaddus VC, Hill A, Brunetta P, Dolganov G, Jablons D, Nishimura S. Integrin alphavbeta8-mediated activation of transforming growth factor-beta inhibits human airway epithelial proliferation in intact bronchial tissue. Am J Pathol. 2003 Aug; 163(2):533-42. PMID: 12875973; PMCID: PMC1868219.
      View in: PubMed, PubMed Central
    39. Jarad G, Wang B, Khan S, DeVore J, Miao H, Wu K, Nishimura S, Wible BA, Konieczkowski M, Sedor JR, Schelling JR. Fas activation induces renal tubular epithelial cell beta 8 integrin expression and function in the absence of apoptosis. J Biol Chem. 2002 Dec 6; 277(49):47826-33. PMID: 12324452.
      View in: PubMed
    40. Mu D, Cambier S, Fjellbirkeland L, Baron JL, Munger JS, Kawakatsu H, Sheppard D, Broaddus VC, Nishimura S. The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1. J Cell Biol. 2002 Apr 29; 157(3):493-507. PMID: 11970960; PMCID: PMC2173277.
      View in: PubMed, PubMed Central
    41. Baron JL, Gardiner L, Nishimura S, Shinkai K, Locksley R, Ganem D. Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection. Immunity. 2002 Apr; 16(4):583-94. PMID: 11970881.
      View in: PubMed
    42. Cambier S, Mu DZ, O'Connell D, Boylen K, Travis W, Liu WH, Broaddus VC, Nishimura S. A role for the integrin alphavbeta8 in the negative regulation of epithelial cell growth. Cancer Res. 2000 Dec 15; 60(24):7084-93. PMID: 11156415.
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    43. Morris AM, Nishimura S, Huang L. Subacute hypersensitivity pneumonitis in an HIV infected patient receiving antiretroviral therapy. Thorax. 2000 Jul; 55(7):625-7. PMID: 10856327; PMCID: PMC1745796.
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    44. Nishimura S, Broaddus VC. Asbestos-induced pleural disease. Clin Chest Med. 1998 Jun; 19(2):311-29. PMID: 9646983.
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    45. Nishimura S, Boylen KP, Einheber S, Milner TA, Ramos DM, Pytela R. Synaptic and glial localization of the integrin alphavbeta8 in mouse and rat brain. Brain Res. 1998 Apr 27; 791(1-2):271-82. PMID: 9593935.
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    46. Ramos DM, Chen BL, Boylen K, Stern M, Kramer RH, Sheppard D, Nishimura S, Greenspan D, Zardi L, Pytela R. Stromal fibroblasts influence oral squamous-cell carcinoma cell interactions with tenascin-C. Int J Cancer. 1997 Jul 17; 72(2):369-76. PMID: 9219848.
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    47. Breuss JM, Gallo J, DeLisser HM, Klimanskaya IV, Folkesson HG, Pittet JF, Nishimura S, Aldape K, Landers DV, Carpenter W. Expression of the beta 6 integrin subunit in development, neoplasia and tissue repair suggests a role in epithelial remodeling. J Cell Sci. 1995 Jun; 108 ( Pt 6):2241-51. PMID: 7673344.
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    48. Nishimura S, Sheppard D, Pytela R. Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain. J Biol Chem. 1994 Nov 18; 269(46):28708-15. PMID: 7525578.
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    49. Weinacker A, Chen A, Agrez M, Cone RI, Nishimura S, Wayner E, Pytela R, Sheppard D. Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor. J Biol Chem. 1994 Mar 4; 269(9):6940-8. PMID: 8120056.
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    50. Frank UK, Nishimura S, Li NC, Sugai K, Yajko DM, Hadley WK, Ng VL. Evaluation of an enzyme immunoassay for detection of cryptococcal capsular polysaccharide antigen in serum and cerebrospinal fluid. J Clin Microbiol. 1993 Jan; 31(1):97-101. PMID: 8417038; PMCID: PMC262628.
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    51. Perkocha LA, Geaghan SM, Yen TS, Nishimura S, Chan SP, Garcia-Kennedy R, Honda G, Stoloff AC, Klein HZ, Goldman RL. Clinical and pathological features of bacillary peliosis hepatis in association with human immunodeficiency virus infection. N Engl J Med. 1990 Dec 6; 323(23):1581-6. PMID: 2233946.
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