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Kamran Atabai, MD

Title(s)Associate Professor, Medicine
SchoolSchool of Medicine
Address555 Mission Bay Blvd South
San Francisco CA 94158
Phone415-514-1159
ORCID ORCID Icon0000-0001-8170-7881 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, San Francisco Postdoctoral StudiesGraduate Division
    Harvard UniversityFellowshipPulmonary/Critical Care
    University of California, San FranciscoResidency School of Medicine - Internal Medicine

    Collapse Overview 
    Collapse Overview
    The main focus of my laboratory is examining the role of the extracellular matrix in regulating metabolism, tissue remodeling, and smooth muscle function as these processes relate to cardiovascular disease. My laboratory has several different areas of investigation that have been generated from studies related to this primary focus. (1) We have been investigating the role of the extracellular matrix in coordinating fatty acid uptake and promoting development of obesity and insulin resistance. (2) We have been examining the role of cell-mediated collagen turnover in regulating the severity of tissue fibrosis using both mouse models of fibrosis and RNAi based whole genome screen of collagen turnover in Drosophila phagocytes. (3) We have been examining the role of the extracellular matrix in regulating inflammation and proliferation in both airway and vascular smooth muscle. In airway smooth muscle, we have been exploring a pathway by which the integrin ligand Mfge8 prevents cytokine-induced increases in calcium sensitivity thereby preventing airway obstruction in models of allergic airway disease. In vascular smooth muscle, we have been focused on understanding the mechanisms by which the matrix promotes neointimal hyperplasia and how these effects regulate vascular disease such as vascular stenosis post percutaneous angioplasty and bypass grafting and pulmonary hypertension.

    Specific projects currently being actively pursued in the lab are as follows:

    1). Understanding the systemic pathways that control absorption of dietary fats and deposition of neutral lipids in peripheral stores. Our goals in this project are to understand what factors systemically regulate lipid metabolism and how these pathways interact with glucose and lipid regulation by insulin. We are particular interested in exploring the link between fatty acids and insulin resistance.

    2). Investigating the role of cell-mediated collagen uptake and degradation in regulating tissue fibrosis. The replacement of normal tissue architecture with collagen-rich fibrotic tissue causes significant morbidity and mortality in multiple organ systems. We have recently shown that macrophage-mediated resorption of fibrillar collagens is important in limiting the severity of lung fibrosis after injury. The goal of this project is to delineate the intracellular pathways that regulate collagen turnover with the ultimate goal of targeting them for treatment of established fibrotic disease.

    3). Inhibiting activation of RhoA to prevent airway constriction in asthma. Bronchoconstriction is the main cause of shortness of breath in asthma and occurs in large part due to an increase in calcium sensitivity induced by allergic inflammation of airway smooth muscle. We have recently identified a pathway that specifically inhibits the ability of cytokines released in the asthmatic airway to increase calcium sensitivity. We are now focused on comprehensively investigating the molecular pathway that mediates these effects with the ultimate goal of targeting them to prevent airway obstruction in asthma as well as to better understand the mechanisms that regulate calcium sensitivity in smooth muscle beds throughout the body.

    Collapse Research 
    Collapse Research Activities and Funding
    Investigating the role of cell-mediated collagen turnover in regulating tissue fibrosis
    NIH/NHLBI R01HL136377Dec 25, 2017 - Nov 30, 2021
    Role: Principal Investigator
    integrin-mediated regulation of enterocyte lipid homeostasis
    NIH/NIDDK R01DK110098Aug 6, 2016 - May 31, 2020
    Role: Principal Investigator
    NRSA Training Core
    NIH/NCATS TL1TR001871Jul 18, 2016 - May 31, 2021
    Role: Co-Principal Investigator
    Identification of Pathways that Regulate Fibrosis through Collagen Resorption
    NIH/NHLBI R21HL107972Apr 1, 2011 - Mar 31, 2013
    Role: Principal Investigator
    The Role of Collagen Uptake in Regulating the Severity of Pulmonary Fibrosis
    NIH/NHLBI R01HL104009Jan 1, 2011 - Dec 31, 2015
    Role: Principal Investigator
    The Role of Mfge8 and Apoptotic Cell Clearance in Regulating Asthma Severity
    NIH/NIAID R03AI081988Jun 5, 2009 - May 31, 2011
    Role: Principal Investigator
    Mfge8 and the Role of Apoptotic Cell Clearance in Lung Injury
    NIH/NHLBI K08HL083985Dec 8, 2006 - Nov 30, 2011
    Role: Principal Investigator
    Signaling Pathway of IL-1Beta Induced TGFBeta Activation
    NIH/NHLBI F32HL073530Jul 1, 2003 - Jun 30, 2006
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. You Say You Want a Resolution (of Fibrosis). Am J Respir Cell Mol Biol. 2020 Jul 08. Atabai K, Yang CD, Podolsky MJ. PMID: 32640171.
      View in: PubMed   Mentions:    Fields:    
    2. CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling. Cell. 2020 Jun 26. Oguri Y, Shinoda K, Kim H, Alba DL, Bolus WR, Wang Q, Brown Z, Pradhan RN, Tajima K, Yoneshiro T, Ikeda K, Chen Y, Cheang RT, Tsujino K, Kim CR, Greiner VJ, Datta R, Yang CD, Atabai K, McManus MT, Koliwad SK, Spiegelman BM, Kajimura S. PMID: 32615086.
      View in: PubMed   Mentions: 2     Fields:    
    3. Age-dependent regulation of cell-mediated collagen turnover. JCI Insight. 2020 May 21; 5(10). Podolsky MJ, Yang CD, Valenzuela CL, Datta R, Huang SK, Nishimura SL, Dallas SL, Wolters PJ, Le Saux CJ, Atabai K. PMID: 32315288.
      View in: PubMed   Mentions:    Fields:    
    4. Fat fibrosis: friend or foe? JCI Insight. 2018 10 04; 3(19). Datta R, Podolsky MJ, Atabai K. PMID: 30282827.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    5. Autocrine Mfge8 Signaling Prevents Developmental Exhaustion of the Adult Neural Stem Cell Pool. Cell Stem Cell. 2018 09 06; 23(3):444-452.e4. Zhou Y, Bond AM, Shade JE, Zhu Y, Davis CO, Wang X, Su Y, Yoon KJ, Phan AT, Chen WJ, Oh JH, Marsh-Armstrong N, Atabai K, Ming GL, Song H. PMID: 30174295.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    6. Deletion of MFGE8 Inhibits Neointima Formation upon Arterial Damage. Thromb Haemost. 2018 07; 118(7):1340-1342. Viola JR, Lemnitzer P, Paulin N, Drechsler M, Nazari-Jahantigh M, Maas S, De Jong RJ, Winter J, Schober A, Weber C, Atabai K, Soehnlein O. PMID: 29864782.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    7. Cell division cycle 7 kinase is a negative regulator of cell-mediated collagen degradation. Am J Physiol Lung Cell Mol Physiol. 2018 09 01; 315(3):L360-L370. Podolsky MJ, Gupta D, Ha A, Ta R, Khalifeh-Soltani A, McKleroy W, Datta R, Sheppard D, Atabai K. PMID: 29792348.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    8. The Mfge8-a8ß1-PTEN pathway regulates airway smooth muscle contraction in allergic inflammation. FASEB J. 2018 May 15; fj201800109R. Khalifeh-Soltani A, Gupta D, Ha A, Podolsky MJ, Datta R, Atabai K. PMID: 29763381.
      View in: PubMed   Mentions:    Fields:    
    9. Mfge8 Binding of the avß5 Integrin Promotes Insulin Resistance in Mice. Diabetes. 2018 May 1; 67(Supplement 1):189-or. RITWIK DATTA, AMIN KHALIFEH-SOLTANI, ARNOLD HA, KAMRAN ATABAI. .
      View in: Publisher Site   Mentions:
    10. Extracellular matrix in lung development, homeostasis and disease. Matrix Biol. 2018 11; 73:77-104. Zhou Y, Horowitz JC, Naba A, Ambalavanan N, Atabai K, Balestrini J, Bitterman PB, Corley RA, Ding BS, Engler AJ, Hansen KC, Hagood JS, Kheradmand F, Lin QS, Neptune E, Niklason L, Ortiz LA, Parks WC, Tschumperlin DJ, White ES, Chapman HA, Thannickal VJ. PMID: 29524630.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    11. Inflammatory bone loss associated with MFG-E8 deficiency is rescued by teriparatide. FASEB J. 2018 07; 32(7):3730-3741. Michalski MN, Seydel AL, Siismets EM, Zweifler LE, Koh AJ, Sinder BP, Aguirre JI, Atabai K, Roca H, McCauley LK. PMID: 29475373.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    12. Inhibition of hepatocyte nuclear factor 1b induces hepatic steatosis through DPP4/NOX1-mediated regulation of superoxide. Free Radic Biol Med. 2017 12; 113:71-83. Long Z, Cao M, Su S, Wu G, Meng F, Wu H, Liu J, Yu W, Atabai K, Wang X. PMID: 28942246.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    13. Cd36 knockout mice are protected against lithogenic diet-induced gallstones. J Lipid Res. 2017 08; 58(8):1692-1701. Xie Y, Cifarelli V, Pietka T, Newberry EP, Kennedy SM, Khalifeh-Soltani A, Clugston R, Atabai K, Abumrad NA, Davidson NO. PMID: 28634191.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    14. Mfge8 regulates enterocyte lipid storage by promoting enterocyte triglyceride hydrolase activity. JCI Insight. 2016 11 03; 1(18):e87418. Khalifeh-Soltani A, Gupta D, Ha A, Iqbal J, Hussain M, Podolsky MJ, Atabai K. PMID: 27812539.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    15. Loss Of Fatty Acid Synthase Increases The Severity Of Lung Fibrosis By Preventing Collagen Resorption. QJM. 2016 Sep 1; 109(suppl_1):s20-s21. Kamran Atabai, Michael Podolsky, Donald Mccarthy. .
      View in: Publisher Site   Mentions:
    16. a8ß1 integrin regulates nutrient absorption through an Mfge8-PTEN dependent mechanism. Elife. 2016 04 19; 5. Khalifeh-Soltani A, Ha A, Podolsky MJ, McCarthy DA, McKleroy W, Azary S, Sakuma S, Tharp KM, Wu N, Yokosaki Y, Hart D, Stahl A, Atabai K. PMID: 27092791.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    17. Prevention of gallbladder hypomotility via FATP2 inhibition protects from lithogenic diet-induced cholelithiasis. Am J Physiol Gastrointest Liver Physiol. 2016 05 15; 310(10):G855-64. Tharp KM, Khalifeh-Soltani A, Park HM, Yurek DA, Falcon A, Wong L, Feng R, Atabai K, Stahl A. PMID: 27033116.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    18. IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction. J Clin Invest. 2014 Nov; 124(11):4895-8. Bhattacharya M, Sundaram A, Kudo M, Farmer J, Ganesan P, Khalifeh-Soltani A, Arjomandi M, Atabai K, Huang X, Sheppard D. PMID: 25271629.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    19. Polarization of prostate cancer-associated macrophages is induced by milk fat globule-EGF factor 8 (MFG-E8)-mediated efferocytosis. J Biol Chem. 2014 Aug 29; 289(35):24560-72. Soki FN, Koh AJ, Jones JD, Kim YW, Dai J, Keller ET, Pienta KJ, Atabai K, Roca H, McCauley LK. PMID: 25006249.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    20. Mfge8 promotes obesity by mediating the uptake of dietary fats and serum fatty acids. Nat Med. 2014 Feb; 20(2):175-83. Khalifeh-Soltani A, McKleroy W, Sakuma S, Cheung YY, Tharp K, Qiu Y, Turner SM, Chawla A, Stahl A, Atabai K. PMID: 24441829.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    21. Functional genomic screen identifies novel mediators of collagen uptake. Mol Biol Cell. 2014 Mar; 25(5):583-93. Lee TH, McKleroy W, Khalifeh-Soltani A, Sakuma S, Lazarev S, Riento K, Nishimura SL, Nichols BJ, Atabai K. PMID: 24403604.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    22. Always cleave up your mess: targeting collagen degradation to treat tissue fibrosis. Am J Physiol Lung Cell Mol Physiol. 2013 Jun 01; 304(11):L709-21. McKleroy W, Lee TH, Atabai K. PMID: 23564511.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    23. Mfge8 suppresses airway hyperresponsiveness in asthma by regulating smooth muscle contraction. Proc Natl Acad Sci U S A. 2013 Jan 08; 110(2):660-5. Kudo M, Khalifeh Soltani SM, Sakuma SA, McKleroy W, Lee TH, Woodruff PG, Lee JW, Huang K, Chen C, Arjomandi M, Huang X, Atabai K. PMID: 23269839.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    24. IL-17A produced by aß T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction. Nat Med. 2012 Mar 04; 18(4):547-54. Kudo M, Melton AC, Chen C, Engler MB, Huang KE, Ren X, Wang Y, Bernstein X, Li JT, Atabai K, Huang X, Sheppard D. PMID: 22388091.
      View in: PubMed   Mentions: 145     Fields:    Translation:HumansAnimalsCells
    25. Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages. J Clin Invest. 2009 Dec; 119(12):3713-22. Atabai K, Jame S, Azhar N, Kuo A, Lam M, McKleroy W, Dehart G, Rahman S, Xia DD, Melton AC, Wolters P, Emson CL, Turner SM, Werb Z, Sheppard D. PMID: 19884654.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    26. Essential role for MFG-E8 as ligand for alphavbeta5 integrin in diurnal retinal phagocytosis. Proc Natl Acad Sci U S A. 2007 Jul 17; 104(29):12005-10. Nandrot EF, Anand M, Almeida D, Atabai K, Sheppard D, Finnemann SC. PMID: 17620600.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    27. Roles of the innate immune system in mammary gland remodeling during involution. J Mammary Gland Biol Neoplasia. 2007 Mar; 12(1):37-45. Atabai K, Sheppard D, Werb Z. PMID: 17286210.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    28. Mfge8 is critical for mammary gland remodeling during involution. Mol Biol Cell. 2005 Dec; 16(12):5528-37. Atabai K, Fernandez R, Huang X, Ueki I, Kline A, Li Y, Sadatmansoori S, Smith-Steinhart C, Zhu W, Pytela R, Werb Z, Sheppard D. PMID: 16195353.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    29. Keratinocyte growth factor can enhance alveolar epithelial repair by nonmitogenic mechanisms. Am J Physiol Lung Cell Mol Physiol. 2002 Jul; 283(1):L163-9. Atabai K, Ishigaki M, Geiser T, Ueki I, Matthay MA, Ware LB. PMID: 12060573.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    30. Aerosolized beta(2)-adrenergic agonists achieve therapeutic levels in the pulmonary edema fluid of ventilated patients with acute respiratory failure. Intensive Care Med. 2002 Jun; 28(6):705-11. Atabai K, Ware LB, Snider ME, Koch P, Daniel B, Nuckton TJ, Matthay MA. PMID: 12107675.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    31. The pulmonary physician in critical care. 5: Acute lung injury and the acute respiratory distress syndrome: definitions and epidemiology. Thorax. 2002 May; 57(5):452-8. Atabai K, Matthay MA. PMID: 11978926.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    32. Human eosinophils induce mucin production in airway epithelial cells via epidermal growth factor receptor activation. J Immunol. 2001 Nov 15; 167(10):5948-54. Burgel PR, Lazarus SC, Tam DC, Ueki IF, Atabai K, Birch M, Nadel JA. PMID: 11698473.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    33. Pulmonary edema fluid from patients with acute lung injury augments in vitro alveolar epithelial repair by an IL-1beta-dependent mechanism. Am J Respir Crit Care Med. 2001 May; 163(6):1384-8. Geiser T, Atabai K, Jarreau PH, Ware LB, Pugin J, Matthay MA. PMID: 11371405.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    34. Increased expression of CD23 (Fc(epsilon) receptor II) by peripheral blood monocytes of aids patients. AIDS Res Hum Retroviruses. 2001 Mar 20; 17(5):443-52. Miller LS, Atabai K, Nowakowski M, Chan A, Bluth MH, Minkoff H, Durkin HG. PMID: 11282013.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    35. Interleukin-1beta augments in vitro alveolar epithelial repair. Am J Physiol Lung Cell Mol Physiol. 2000 Dec; 279(6):L1184-90. Geiser T, Jarreau PH, Atabai K, Matthay MA. PMID: 11076808.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
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