Daniel Sirkis, PhD

Title(s)Specialist, Neurology
SchoolSchool of Medicine
Address1651 4th Street, #42308
San Francisco CA 94158
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    Collapse Research 
    Collapse Research Activities and Funding
    Biochemical dissection of amyloid precursor protein transport from the Golgi
    NIH F32AG050404May 1, 2015 - Apr 30, 2018
    Role: Principal Investigator
    Biogenesis of the Regulated Secretory Pathway
    NIH F31MH085406Apr 16, 2009 - Apr 15, 2013
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Frontotemporal lobar degeneration targets brain regions linked to expression of recently evolved genes. Brain. 2024 Jun 28. Pasquini L, Pereira FL, Seddighi S, Zeng Y, Wei Y, Illán-Gala I, Vatsavayai SC, Friedberg A, Lee AJ, Brown JA, Spina S, Grinberg LT, Sirkis DW, Bonham LW, Yokoyama JS, Boxer AL, Kramer JH, Rosen HJ, Humphrey J, Gitler AD, Miller BL, Pollard KS, Ward ME, Seeley WW. PMID: 38940350.
      View in: PubMed   Mentions:    Fields:    
    2. Expansion of highly interferon-responsive T cells in early-onset Alzheimer's disease. Alzheimers Dement. 2024 07; 20(7):5062-5070. Sirkis DW, Warly Solsberg C, Johnson TP, Bonham LW, Oddi AP, Geier EG, Miller BL, Rabinovici GD, Yokoyama JS. PMID: 38829682; PMCID: PMC11247696.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    3. C9orf72 gene networks in the human brain correlate with cortical thickness in C9-FTD and implicate vulnerable cell types. Front Neurosci. 2024; 18:1258996. Broce IJ, Sirkis DW, Nillo RM, Bonham LW, Lee SE, Miller BL, Castruita PA, Sturm VE, Sugrue LS, Desikan RS, Yokoyama JS. PMID: 38469573; PMCID: PMC10925697.
      View in: PubMed   Mentions:
    4. Expansion of highly interferon-responsive T cells in early-onset Alzheimer's disease. bioRxiv. 2024 Jan 10. Sirkis DW, Solsberg CW, Johnson TP, Bonham LW, Oddi AP, Geier EG, Miller BL, Rabinovici GD, Yokoyama JS. PMID: 37823036; PMCID: PMC10563505.
      View in: PubMed   Mentions:
    5. FTLD targets brain regions expressing recently evolved genes. medRxiv. 2023 Oct 28. Pasquini L, Pereira FL, Seddighi S, Zeng Y, Wei Y, Illán-Gala I, Vatsavayai SC, Friedberg A, Lee AJ, Brown JA, Spina S, Grinberg LT, Sirkis DW, Bonham LW, Yokoyama JS, Boxer AL, Kramer JH, Rosen HJ, Humphrey J, Gitler AD, Miller BL, Pollard KS, Ward ME, Seeley WW. PMID: 37961381; PMCID: PMC10635220.
      View in: PubMed   Mentions: 1  
    6. Early-onset Alzheimer's disease explained by polygenic risk of late-onset disease? Alzheimers Dement (Amst). 2023 Oct-Dec; 15(4):e12482. Mantyh WG, Cochran JN, Taylor JW, Broce IJ, Geier EG, Bonham LW, Anderson AG, Sirkis DW, Joie R, Iaccarino L, Chaudhary K, Edwards L, Strom A, Grant H, Allen IE, Miller ZA, Gorno-Tempini ML, Kramer JH, Miller BL, Desikan RS, Rabinovici GD, Yokoyama JS. PMID: 37780862; PMCID: PMC10535074.
      View in: PubMed   Mentions: 2  
    7. Role for cell death pathway in Alzheimer's disease. Science. 2023 09 15; 381(6663):1156-1157. Sirkis DW, Yokoyama JS. PMID: 37708264.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    8. C9orf72 gene networks in the human brain correlate with cortical thickness in C9-FTD and implicate vulnerable cell types. bioRxiv. 2023 Aug 03. Broce IJ, Sirkis DW, Nillo RM, Bonham LW, Lee SE, Miller B, Castruita P, Sturm VE, Sugrue LS, Desikan RS, Yokoyama JS. PMID: 37503230; PMCID: PMC10370095.
      View in: PubMed   Mentions:
    9. Single-cell RNA-seq reveals alterations in peripheral CX3CR1 and nonclassical monocytes in familial tauopathy. Genome Med. 2023 07 18; 15(1):53. Sirkis DW, Warly Solsberg C, Johnson TP, Bonham LW, Sturm VE, Lee SE, Rankin KP, Rosen HJ, Boxer AL, Seeley WW, Miller BL, Geier EG, Yokoyama JS. PMID: 37464408; PMCID: PMC10354988.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    10. Frontotemporal dementia presentation in patients with heterozygous p.H157Y variant of TREM2. J Med Genet. 2023 09; 60(9):894-904. Ogonowski N, Santamaria-Garcia H, Baez S, Lopez A, Laserna A, Garcia-Cifuentes E, Ayala-Ramirez P, Zarante I, Suarez-Obando F, Reyes P, Kauffman M, Cochran N, Schulte M, Sirkis DW, Spina S, Yokoyama JS, Miller BL, Kosik KS, Matallana D, Ibáñez A. PMID: 36813542; PMCID: PMC10447405.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Unconventional secretion of α-synuclein mediated by palmitoylated DNAJC5 oligomers. Elife. 2023 01 10; 12. Wu S, Hernandez Villegas NC, Sirkis DW, Thomas-Wright I, Wade-Martins R, Schekman R. PMID: 36626307; PMCID: PMC9876576.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    12. Radiogenomics of C9orf72 Expansion Carriers Reveals Global Transposable Element Derepression and Enables Prediction of Thalamic Atrophy and Clinical Impairment. J Neurosci. 2023 01 11; 43(2):333-345. Bonham LW, Geier EG, Sirkis DW, Leong JK, Ramos EM, Wang Q, Karydas A, Lee SE, Sturm VE, Sawyer RP, Friedberg A, Ichida JK, Gitler AD, Sugrue L, Cordingley M, Bee W, Weber E, Kramer JH, Rankin KP, Rosen HJ, Boxer AL, Seeley WW, Ravits J, Miller BL, Yokoyama JS. PMID: 36446586; PMCID: PMC9838702.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    13. Dissecting the clinical heterogeneity of early-onset Alzheimer's disease. Mol Psychiatry. 2022 06; 27(6):2674-2688. Sirkis DW, Bonham LW, Johnson TP, La Joie R, Yokoyama JS. PMID: 35393555; PMCID: PMC9156414.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    14. The Role of Microglia in Inherited White-Matter Disorders and Connections to Frontotemporal Dementia. Appl Clin Genet. 2021; 14:195-207. Sirkis DW, Bonham LW, Yokoyama JS. PMID: 33833548; PMCID: PMC8020808.
      View in: PubMed   Mentions: 10  
    15. The Radiogenomics of Late-onset Alzheimer Disease. Top Magn Reson Imaging. 2019 Dec; 28(6):325-334. Bonham LW, Sirkis DW, Hess CP, Sugrue LP, Yokoyama JS. PMID: 31794505.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. The Transcriptional Landscape of Microglial Genes in Aging and Neurodegenerative Disease. Front Immunol. 2019; 10:1170. Bonham LW, Sirkis DW, Yokoyama JS. PMID: 31214167; PMCID: PMC6557985.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    17. Immunological signatures in frontotemporal lobar degeneration. Curr Opin Neurol. 2019 04; 32(2):272-278. Sirkis DW, Bonham LW, Karch CM, Yokoyama JS. PMID: 30672824; PMCID: PMC8025661.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    18. Recent advances in the genetics of frontotemporal dementia. Curr Genet Med Rep. 2019 Mar; 7(1):41-52. Sirkis DW, Geier EG, Bonham LW, Karch CM, Yokoyama JS. PMID: 31687268; PMCID: PMC6827567.
      View in: PubMed   Mentions: 27  
    19. Rare variants in the neuronal ceroid lipofuscinosis gene MFSD8 are candidate risk factors for frontotemporal dementia. Acta Neuropathol. 2019 01; 137(1):71-88. Geier EG, Bourdenx M, Storm NJ, Cochran JN, Sirkis DW, Hwang JH, Bonham LW, Ramos EM, Diaz A, Van Berlo V, Dokuru D, Nana AL, Karydas A, Balestra ME, Huang Y, Russo SP, Spina S, Grinberg LT, Seeley WW, Myers RM, Miller BL, Coppola G, Lee SE, Cuervo AM, Yokoyama JS. PMID: 30382371; PMCID: PMC6371791.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    20. Neurodegeneration-associated mutant TREM2 proteins abortively cycle between the ER and ER-Golgi intermediate compartment. Mol Biol Cell. 2017 Oct 01; 28(20):2723-2733. Sirkis DW, Aparicio RE, Schekman R. PMID: 28768830; PMCID: PMC5620379.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    21. Identification of a rare coding variant in TREM2 in a Chinese individual with Alzheimer's disease. Neurocase. 2017 Feb; 23(1):65-69. Bonham LW, Sirkis DW, Fan J, Aparicio RE, Tse M, Ramos EM, Wang Q, Coppola G, Rosen HJ, Miller BL, Yokoyama JS. PMID: 28376694; PMCID: PMC5639900.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    22. Rare TREM2 variants associated with Alzheimer's disease display reduced cell surface expression. Acta Neuropathol Commun. 2016 09 02; 4(1):98. Sirkis DW, Bonham LW, Aparicio RE, Geier EG, Ramos EM, Wang Q, Karydas A, Miller ZA, Miller BL, Coppola G, Yokoyama JS. PMID: 27589997; PMCID: PMC5010724.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    23. Radiotherapy followed by aurora kinase inhibition targets tumor-propagating cells in human glioblastoma. Mol Cancer Ther. 2015 Feb; 14(2):419-28. Li N, Maly DJ, Chanthery YH, Sirkis DW, Nakamura JL, Berger MS, James CD, Shokat KM, Weiss WA, Persson AI. PMID: 25522764; PMCID: PMC4326592.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    24. Protein sorting at the trans-Golgi network. Annu Rev Cell Dev Biol. 2014; 30:169-206. Guo Y, Sirkis DW, Schekman R. PMID: 25150009.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansAnimalsCells
    25. C9ORF72 hexanucleotide repeats in behavioral and motor neuron disease: clinical heterogeneity and pathological diversity. Am J Neurodegener Dis. 2014; 3(1):1-18. Yokoyama JS, Sirkis DW, Miller BL. PMID: 24753999; PMCID: PMC3986607.
      View in: PubMed   Mentions: 12  
    26. Self-assembly of VPS41 promotes sorting required for biogenesis of the regulated secretory pathway. Dev Cell. 2013 Nov 25; 27(4):425-37. Asensio CS, Sirkis DW, Maas JW, Egami K, To TL, Brodsky FM, Shu X, Cheng Y, Edwards RH. PMID: 24210660; PMCID: PMC3974617.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    27. Widespread dysregulation of peptide hormone release in mice lacking adaptor protein AP-3. PLoS Genet. 2013; 9(9):e1003812. Sirkis DW, Edwards RH, Asensio CS. PMID: 24086151; PMCID: PMC3784564.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    28. RNAi screen identifies a role for adaptor protein AP-3 in sorting to the regulated secretory pathway. J Cell Biol. 2010 Dec 13; 191(6):1173-87. Asensio CS, Sirkis DW, Edwards RH. PMID: 21149569; PMCID: PMC3002028.
      View in: PubMed   Mentions: 35     Fields:    Translation:Animals
    29. Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis. J Neurosci. 2008 Dec 10; 28(50):13574-81. Vargas MR, Johnson DA, Sirkis DW, Messing A, Johnson JA. PMID: 19074031; PMCID: PMC2866507.
      View in: PubMed   Mentions: 237     Fields:    Translation:HumansAnimalsCells
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