Frances Brodsky, PhD

Title(s)Professor, Bioengineering
SchoolSchool of Pharmacy
Address1700 4th St.
San Francisco CA 94158
ORCID ORCID Icon0000-0002-1334-9258 Additional info
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    Collapse Biography 
    Collapse Awards and Honors
    1975Phi Beta Kappa, Junior year Camille and Henry Dreyfus Fellowship for Summer Research
    1976Marshall Scholarship
    1980Damon Runyon-Walter Winchell Fund Postdoctoral Fellowship
    1987Pharmaceutical Manufacturers Association Fund, Research Starter Grant
    1988Pew Scholars Program
    McGill University2005Boehringer-Ingleheim Lecturer
    University of Queensland2005Honorary Professor
    University of California, San Francisco2005Commencement Speaker for Graduate Programs
    National Institutes of Health2006Margaret Pittman Lecturer
    King's College, Cambridge2006Visiting Fellowship
    American Society of Cell Biology2007Senior Career Award, Women in Cell Biology
    University of Massachusetts2008Kai Lin Memorial Lecturer
    Lysosomes Gordon Research Conference2008Elected Vice-Chair
    Lysosomes Gordon Research Conference2010Elected Chair
    Harris-Manchester College, Oxford University2010Lord Harris Visiting Professor
    Karolinska Institute Stockholm, Sweden2011Diabetes Symposium Invited Speaker

    Collapse Overview 
    Collapse Overview
    Clathrin is a self-assembling protein that controls the formation of intracellular transport vesicles required for several key membrane traffic pathways. These include receptor-mediated endocytosis and biogenesis of lysosomes and secretory granules. Thus clathrin plays a critical role in cell growth control, antigen presentation, neuronal function and hormone secretion. Malfunction of clathrin pathways is associated with development of cancer, heart disease and neuronal defects. Clathrin-mediated pathways are also subverted by certain viruses and intracellular bacteria to facilitate their infection. A novel isoform of clathrin (CHC22) that is primarily expressed in skeletal muscle, cardiac muscle and fat has been recently characterized by the Brodsky laboratory. Its tissue-specific function is to package the GLUT4 glucose transporter into intracellular vesicles that are released in response to insulin stimulation, leading to clearance of glucose from the bloodstream. This CHC22 clathrin isoform is therefore associated with pathways that are defective in type 2 diabetes. The focus of the Brodsky laboratory since 1982 has been to define the biochemistry, regulation, evolution and physiological function of the clathrin subunits and their isoforms, focusing on their role in disease states, as well as in normal cellular physiology. The laboratory has made significant contributions in these areas over the years and maintains an international reputation for expertise on clathrin structure and function.
    There are four current projects in the laboratory. These projects aim to define the comparative functions of the two clathrin heavy chain (CHC) isoforms (CHC17 and CHC22) and the two clathrin light chain isoforms (LCa and LCb). The regulation of CHC17 clathrin function by signaling pathways and the cooperation of CHC17 clathrin with the actin cytoskeleton through clathrin light chain interaction with the actin-binding Hip proteins is being investigated in the context of cell adhesion and migration. Establishing the mechanistic role of CHC22 clathrin in GLUT4 transport and pathways that malfunction in type 2 diabetes is also a major goal for the laboratory.

    Collapse Research 
    Collapse Research Activities and Funding
    Biochemistry and Cell Biology of CHC22 Clathrin
    NIH/NIDDK R01DK095663Dec 1, 2012 - Nov 30, 2016
    Role: Principal Investigator
    NIH/NIDDK R56DK083589Sep 20, 2009 - Aug 31, 2011
    Role: Principal Investigator
    2008-2010 Lysosomes &Endocytosis Gordon Research Conference
    NIH/NIGMS R13GM084519May 1, 2008 - Apr 30, 2011
    Role: Principal Investigator
    Human Natural Killer Cell Biology
    NIH/NIAID P01AI064520Sep 16, 2005 - Feb 28, 2011
    Role: Principal Investigator
    NIH/NIGMS R01GM061954Jul 1, 2000 - Jun 30, 2004
    Role: Principal Investigator
    NIH/NIAID P01AI045865Sep 30, 1999 - Aug 31, 2003
    Role: Principal Investigator
    NIH/NIGMS R01GM057657Aug 1, 1997 - Jul 31, 2003
    Role: Principal Investigator
    NIH/NIGMS R01GM057656Aug 1, 1997 - Jul 31, 2001
    Role: Co-Investigator
    NIH/NIGMS R21GM055143Jul 1, 1997 - Jun 30, 2000
    Role: Principal Investigator
    NIH/NIGMS R01GM046205May 1, 1992 - Apr 30, 1997
    Role: Principal Investigator
    Cellular Regulation of Clathrin Assembly and Function
    NIH/NIGMS R01GM038093Feb 1, 1988 - Jul 31, 2007
    Role: Principal Investigator
    NIH/NIAMS P60AR020684Apr 1, 1986 - Dec 31, 2003
    Role: Co-Investigator
    NIH/NIGMS P50GM026691Aug 1, 1979 - Jul 31, 1998
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse In The News
    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. In Memoriam: Peter Hartmann (1946-2020), publisher, colleague and friend. Traffic. 2020 Sep 27. Brodsky FM, Parham P. PMID: 32981140.
      View in: PubMed   Mentions:    Fields:    
    2. Clathrin light chain diversity regulates membrane deformation in vitro and synaptic vesicle formation in vivo. Proc Natl Acad Sci U S A. 2020 Sep 22; 117(38):23527-23538. Redlingshöfer L, McLeod F, Chen Y, Camus MD, Burden JJ, Palomer E, Briant K, Dannhauser PN, Salinas PC, Brodsky FM. PMID: 32907943.
      View in: PubMed   Mentions:    Fields:    
    3. Clathrin's life beyond 40: Connecting biochemistry with physiology and disease. Curr Opin Cell Biol. 2020 Aug 21; 65:141-149. Briant K, Redlingshöfer L, Brodsky FM. PMID: 32836101.
      View in: PubMed   Mentions:    Fields:    
    4. Building GLUT4 Vesicles: CHC22 Clathrin's Human Touch. Trends Cell Biol. 2020 Sep; 30(9):705-719. Gould GW, Brodsky FM, Bryant NJ. PMID: 32620516.
      View in: PubMed   Mentions:    Fields:    
    5. Lipid Metabolism Links Nutrient-Exercise Timing to Insulin Sensitivity in Men Classified as Overweight or Obese. J Clin Endocrinol Metab. 2020 Mar 01; 105(3). Edinburgh RM, Bradley HE, Abdullah NF, Robinson SL, Chrzanowski-Smith OJ, Walhin JP, Joanisse S, Manolopoulos KN, Philp A, Hengist A, Chabowski A, Brodsky FM, Koumanov F, Betts JA, Thompson D, Wallis GA, Gonzalez JT. PMID: 31628477.
      View in: PubMed   Mentions:    Fields:    
    6. CHC22 clathrin mediates traffic from early secretory compartments for human GLUT4 pathway biogenesis. J Cell Biol. 2020 01 06; 219(1). Camus SM, Camus MD, Figueras-Novoa C, Boncompain G, Sadacca LA, Esk C, Bigot A, Gould GW, Kioumourtzoglou D, Perez F, Bryant NJ, Mukherjee S, Brodsky FM. PMID: 31863584.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    7. Twenty years of Traffic. Traffic. 2020 01; 21(1):4-5. Marks MS, Tooze SA, Brodsky FM, Marsh M, Parton RG, Schroer TA. PMID: 31854088.
      View in: PubMed   Mentions:    Fields:    
    8. Looking back to traffic forward: A tribute to Thomas Kreis (1952-1998) and his inspiration. Traffic. 2020 01; 21(1):186-188. Brodsky FM, Perez F. PMID: 31520505.
      View in: PubMed   Mentions:    Fields:    
    9. Clathrin light chain A drives selective myosin VI recruitment to clathrin-coated pits under membrane tension. Nat Commun. 2019 10 31; 10(1):4974. Biancospino M, Buel GR, Niño CA, Maspero E, Scotto di Perrotolo R, Raimondi A, Redlingshöfer L, Weber J, Brodsky FM, Walters KJ, Polo S. PMID: 31672988.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    10. The AP2 adaptor enhances clathrin coat stiffness. FEBS J. 2019 10; 286(20):4074-4085. Lherbette M, Redlingshöfer L, Brodsky FM, Schaap IAT, Dannhauser PN. PMID: 31199077.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    11. Genetic diversity of CHC22 clathrin impacts its function in glucose metabolism. Elife. 2019 06 04; 8. Fumagalli M, Camus SM, Diekmann Y, Burke A, Camus MD, Norman PJ, Joseph A, Abi-Rached L, Benazzo A, Rasteiro R, Mathieson I, Topf M, Parham P, Thomas MG, Brodsky FM. PMID: 31159924.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    12. CHC22 and CHC17 clathrins have distinct biochemical properties and display differential regulation and function. J Biol Chem. 2017 12 22; 292(51):20834-20844. Dannhauser PN, Camus SM, Sakamoto K, Sadacca LA, Torres JA, Camus MD, Briant K, Vassilopoulos S, Rothnie A, Smith CJ, Brodsky FM. PMID: 29097553.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    13. Clathrin light chains' role in selective endocytosis influences antibody isotype switching. Proc Natl Acad Sci U S A. 2016 08 30; 113(35):9816-21. Wu S, Majeed SR, Evans TM, Camus MD, Wong NM, Schollmeier Y, Park M, Muppidi JR, Reboldi A, Parham P, Cyster JG, Brodsky FM. PMID: 27540116.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    14. A Distinctive Cytoplasmic Tail Contributes to Low Surface Expression and Intracellular Retention of the Patr-AL MHC Class I Molecule. J Immunol. 2015 Oct 15; 195(8):3725-36. Goyos A, Guethlein LA, Horowitz A, Hilton HG, Gleimer M, Brodsky FM, Parham P. PMID: 26371256.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    15. Unconventional functions for clathrin, ESCRTs, and other endocytic regulators in the cytoskeleton, cell cycle, nucleus, and beyond: links to human disease. Cold Spring Harb Perspect Biol. 2014 Sep 02; 6(9):a017004. Brodsky FM, Sosa RT, Ybe JA, O'Halloran TJ. PMID: 25183831.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    16. Clathrin light chains are required for the gyrating-clathrin recycling pathway and thereby promote cell migration. Nat Commun. 2014 May 23; 5:3891. Majeed SR, Vasudevan L, Chen CY, Luo Y, Torres JA, Evans TM, Sharkey A, Foraker AB, Wong NM, Esk C, Freeman TA, Moffett A, Keen JH, Brodsky FM. PMID: 24852344.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    17. Actin scaffolding by clathrin heavy chain is required for skeletal muscle sarcomere organization. J Cell Biol. 2014 May 12; 205(3):377-93. Vassilopoulos S, Gentil C, Lainé J, Buclez PO, Franck A, Ferry A, Précigout G, Roth R, Heuser JE, Brodsky FM, Garcia L, Bonne G, Voit T, Piétri-Rouxel F, Bitoun M. PMID: 24798732.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    18. The adaptor protein GULP promotes Jedi-1-mediated phagocytosis through a clathrin-dependent mechanism. Mol Biol Cell. 2014 Jun 15; 25(12):1925-36. Sullivan CS, Scheib JL, Ma Z, Dang RP, Schafer JM, Hickman FE, Brodsky FM, Ravichandran KS, Carter BD. PMID: 24743597.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    19. Self-assembly of VPS41 promotes sorting required for biogenesis of the regulated secretory pathway. Dev Cell. 2013 Nov 25; 27(4):425-37. Asensio CS, Sirkis DW, Maas JW, Egami K, To TL, Brodsky FM, Shu X, Cheng Y, Edwards RH. PMID: 24210660.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    20. The CHC22 clathrin-GLUT4 transport pathway contributes to skeletal muscle regeneration. PLoS One. 2013; 8(10):e77787. Hoshino S, Sakamoto K, Vassilopoulos S, Camus SM, Griffin CA, Esk C, Torres JA, Ohkoshi N, Ishii A, Tamaoka A, Funke BH, Kucherlapati R, Margeta M, Rando TA, Brodsky FM. PMID: 24204966.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    21. Frances Brodsky: so you think you know all about clathrin? Interview by Caitlin Sedwick. J Cell Biol. 2013 Sep 16; 202(6):830-1. Brodsky F. PMID: 24043697.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    22. A cost-benefit analysis of the physical mechanisms of membrane curvature. Nat Cell Biol. 2013 Sep; 15(9):1019-27. Stachowiak JC, Brodsky FM, Miller EA. PMID: 23999615.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    23. Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):E3138-47. Holmes BB, DeVos SL, Kfoury N, Li M, Jacks R, Yanamandra K, Ouidja MO, Brodsky FM, Marasa J, Bagchi DP, Kotzbauer PT, Miller TM, Papy-Garcia D, Diamond MI. PMID: 23898162.
      View in: PubMed   Mentions: 203     Fields:    Translation:HumansAnimalsCells
    24. Hsc70-induced changes in clathrin-auxilin cage structure suggest a role for clathrin light chains in cage disassembly. Traffic. 2013 Sep; 14(9):987-96. Young A, Stoilova-McPhie S, Rothnie A, Vallis Y, Harvey-Smith P, Ranson N, Kent H, Brodsky FM, Pearse BM, Roseman A, Smith CJ. PMID: 23710728.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    25. Anisotropic nanocrystal arrays organized on protein lattices formed by recombinant clathrin fragments. J Mater Chem. 2012 Dec 28; 22(44):23335-23339. Hom N, Mehta KR, Chou T, Foraker AB, Brodsky FM, Kirshenbaum K, Montclare JK. PMID: 23836951.
      View in: PubMed   Mentions:
    26. A common clathrin-mediated machinery co-ordinates cell-cell adhesion and bacterial internalization. Traffic. 2012 Dec; 13(12):1653-66. Bonazzi M, Kühbacher A, Toledo-Arana A, Mallet A, Vasudevan L, Pizarro-Cerdá J, Brodsky FM, Cossart P. PMID: 22984946.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    27. Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG. J Cell Biol. 2012 Aug 20; 198(4):591-605. Foraker AB, Camus SM, Evans TM, Majeed SR, Chen CY, Taner SB, Corrêa IR, Doxsey SJ, Brodsky FM. PMID: 22891263.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    28. Diversity of clathrin function: new tricks for an old protein. Annu Rev Cell Dev Biol. 2012; 28:309-36. Brodsky FM. PMID: 22831640.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    29. Evolutionary cell biology: Lessons from diversity. Nat Cell Biol. 2012 Jun 29; 14(7):651. Brodsky FM, Thattai M, Mayor S. PMID: 22743706.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    30. Clathrin phosphorylation is required for actin recruitment at sites of bacterial adhesion and internalization. J Cell Biol. 2011 Oct 31; 195(3):525-36. Bonazzi M, Vasudevan L, Mallet A, Sachse M, Sartori A, Prevost MC, Roberts A, Taner SB, Wilbur JD, Brodsky FM, Cossart P. PMID: 22042622.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    31. Endocytosis regulates cell soma translocation and the distribution of adhesion proteins in migrating neurons. PLoS One. 2011 Mar 22; 6(3):e17802. Shieh JC, Schaar BT, Srinivasan K, Brodsky FM, McConnell SK. PMID: 21445347.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    32. Interactions of NK cell receptor KIR3DL1*004 with chaperones and conformation-specific antibody reveal a functional folded state as well as predominant intracellular retention. J Immunol. 2011 Jan 01; 186(1):62-72. Taner SB, Pando MJ, Roberts A, Schellekens J, Marsh SG, Malmberg KJ, Parham P, Brodsky FM. PMID: 21115737.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    33. Conformation switching of clathrin light chain regulates clathrin lattice assembly. Dev Cell. 2010 May 18; 18(5):841-8. Wilbur JD, Hwang PK, Ybe JA, Lane M, Sellers BD, Jacobson MP, Fletterick RJ, Brodsky FM. PMID: 20493816.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    34. Accommodation of structural rearrangements in the huntingtin-interacting protein 1 coiled-coil domain. Acta Crystallogr D Biol Crystallogr. 2010 Mar; 66(Pt 3):314-8. Wilbur JD, Hwang PK, Brodsky FM, Fletterick RJ. PMID: 20179344.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    35. The clathrin heavy chain isoform CHC22 functions in a novel endosomal sorting step. J Cell Biol. 2010 Jan 11; 188(1):131-44. Esk C, Chen CY, Johannes L, Brodsky FM. PMID: 20065094.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    36. [The CHC22 human clathrin heavy chain isoform, intracellular traffic of the glucose transporter GLUT4, and type 2 diabetes]. Med Sci (Paris). 2010 Jan; 26(1):33-6. Vassilopoulos S, Esk C, Hoshino S, Brodsky FM. PMID: 20132771.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    37. Dimorphic motifs in D0 and D1+D2 domains of killer cell Ig-like receptor 3DL1 combine to form receptors with high, moderate, and no avidity for the complex of a peptide derived from HIV and HLA-A*2402. J Immunol. 2009 Oct 01; 183(7):4569-82. Sharma D, Bastard K, Guethlein LA, Norman PJ, Yawata N, Yawata M, Pando M, Thananchai H, Dong T, Rowland-Jones S, Brodsky FM, Parham P. PMID: 19752231.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    38. A role for the CHC22 clathrin heavy-chain isoform in human glucose metabolism. Science. 2009 May 29; 324(5931):1192-6. Vassilopoulos S, Esk C, Hoshino S, Funke BH, Chen CY, Plocik AM, Wright WE, Kucherlapati R, Brodsky FM. PMID: 19478182.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    39. Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain. J Biol Chem. 2008 Nov 21; 283(47):32870-9. Wilbur JD, Chen CY, Manalo V, Hwang PK, Fletterick RJ, Brodsky FM. PMID: 18790740.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    40. Evolutionary analysis and molecular dissection of caveola biogenesis. J Cell Sci. 2008 Jun 15; 121(Pt 12):2075-86. Kirkham M, Nixon SJ, Howes MT, Abi-Rached L, Wakeham DE, Hanzal-Bayer M, Ferguson C, Hill MM, Fernandez-Rojo M, Brown DA, Hancock JF, Brodsky FM, Parton RG. PMID: 18505796.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    41. Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission. Nat Cell Biol. 2008 Feb; 10(2):211-9. Sowinski S, Jolly C, Berninghausen O, Purbhoo MA, Chauveau A, Köhler K, Oddos S, Eissmann P, Brodsky FM, Hopkins C, Onfelt B, Sattentau Q, Davis DM. PMID: 18193035.
      View in: PubMed   Mentions: 286     Fields:    Translation:HumansCells
    42. Novel binding sites on clathrin and adaptors regulate distinct aspects of coat assembly. Traffic. 2006 Dec; 7(12):1688-700. Knuehl C, Chen CY, Manalo V, Hwang PK, Ota N, Brodsky FM. PMID: 17052248.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    43. TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis. J Exp Med. 2005 Oct 03; 202(7):955-65. Chen TT, Li L, Chung DH, Allen CD, Torti SV, Torti FM, Cyster JG, Chen CY, Brodsky FM, Niemi EC, Nakamura MC, Seaman WE, Daws MR. PMID: 16203866.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    44. Clathrin heavy and light chain isoforms originated by independent mechanisms of gene duplication during chordate evolution. Proc Natl Acad Sci U S A. 2005 May 17; 102(20):7209-14. Wakeham DE, Abi-Rached L, Towler MC, Wilbur JD, Parham P, Brodsky FM. PMID: 15883369.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    45. New faces of the familiar clathrin lattice. Traffic. 2005 Apr; 6(4):346-50. Wilbur JD, Hwang PK, Brodsky FM. PMID: 15752139.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    46. Plasticity of B cell receptor internalization upon conditional depletion of clathrin. Mol Biol Cell. 2005 May; 16(5):2339-48. Stoddart A, Jackson AP, Brodsky FM. PMID: 15716350.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    47. Cell biology: clathrin's Achilles' ankle. Nature. 2004 Dec 02; 432(7017):568-9. Brodsky FM. PMID: 15577897.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    48. Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo. J Biol Chem. 2005 Feb 18; 280(7):6109-17. Chen CY, Brodsky FM. PMID: 15533940.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    49. The B lymphocyte adaptor molecule of 32 kilodaltons (Bam32) regulates B cell antigen receptor internalization. J Immunol. 2004 Nov 01; 173(9):5601-9. Niiro H, Allam A, Stoddart A, Brodsky FM, Marshall AJ, Clark EA. PMID: 15494510.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    50. Clathrin isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting nexin 5 and has increased expression during myogenesis and muscle regeneration. Mol Biol Cell. 2004 Jul; 15(7):3181-95. Towler MC, Gleeson PA, Hoshino S, Rahkila P, Manalo V, Ohkoshi N, Ordahl C, Parton RG, Brodsky FM. PMID: 15133132.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    51. T cell receptor engagement leads to phosphorylation of clathrin heavy chain during receptor internalization. J Exp Med. 2004 Apr 05; 199(7):981-91. Crotzer VL, Mabardy AS, Weiss A, Brodsky FM. PMID: 15067034.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    52. Membrane traffic in skeletal muscle. Traffic. 2004 Mar; 5(3):129-39. Towler MC, Kaufman SJ, Brodsky FM. PMID: 15086789.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    53. Clathrin self-assembly involves coordinated weak interactions favorable for cellular regulation. EMBO J. 2003 Oct 01; 22(19):4980-90. Wakeham DE, Chen CY, Greene B, Hwang PK, Brodsky FM. PMID: 14517237.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    54. The long and short of adaptor appendages. Nat Struct Biol. 2003 Aug; 10(8):580-2. Knuehl C, Brodsky FM. PMID: 12886287.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    55. Clathrin light and heavy chain interface: alpha-helix binding superhelix loops via critical tryptophans. EMBO J. 2002 Nov 15; 21(22):6072-82. Chen CY, Reese ML, Hwang PK, Ota N, Agard D, Brodsky FM. PMID: 12426379.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    56. Lipid rafts unite signaling cascades with clathrin to regulate BCR internalization. Immunity. 2002 Oct; 17(4):451-62. Stoddart A, Dykstra ML, Brown BK, Song W, Pierce SK, Brodsky FM. PMID: 12387739.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    57. Short RNA duplexes produced by hydrolysis with Escherichia coli RNase III mediate effective RNA interference in mammalian cells. Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15):9942-7. Yang D, Buchholz F, Huang Z, Goga A, Chen CY, Brodsky FM, Bishop JM. PMID: 12096193.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
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