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David Daikh, MD

Title(s)PROF OF CLIN-HCOMP, Medicine
SchoolSchool of Medicine
Phone415-750-2104 ext. 3387
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    Collapse Biography 
    Collapse Education and Training
    Oregon Health Sciences University, Portland, ORMD6/1991Medicine
    Oregon Health Sciences University, Portland, ORPhD6/1991Biochemistry and Molecular Biology
    University of California, San Francisco, San Francisco, CAResidency6/1994Internal Medicine
    University of California, San Francisco, San Francisco, CAFellowship6/1997Rheumatology

    Collapse Overview 
    Collapse Overview
    Dr. Daikh is the Rheumatology Division Chief at the SFVA Medical Center, and director of the rheumatology fellowship program at UCSF. Dr. Daikh is a UCSF Department of Medicine Master Clinician and a member of the UCSF Academy of Medical Educators. Dr. Daikh’s research has focused on immune mechanisms of rheumatic disease and novel approaches to immunotherapy. Dr. Daikh is a past president of the Rheumatology Research Foundation and is the Immediate Past President of the American College of Rheumatology.

    Collapse Research 
    Collapse Research Activities and Funding
    A Controlled Trial of CBT for Multiple Sclerosis Inflammation
    NIH/NICHD R01HD043323Sep 1, 2003 - Jun 30, 2011
    Role: Principal Investigator
    T CELL COST IMMULATION ON MURINE LUPUS
    NIH/NIAID K08AI001520Sep 1, 1997 - Aug 31, 2003
    Role: Principal Investigator
    Academic Rheumatology and Clinical Immunology
    NIH/NIAMS T32AR007304Jul 1, 1978 - Apr 30, 2020
    Role: Principal Investigator
    MULTIPURPOSE ARTHRITIS AND MUSCULOSKELETAL DISEASES CTR
    NIH/NIAMS P60AR020684Sep 15, 1977 - Dec 31, 2003
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Aringer M, Costenbader K, Daikh D, Brinks R, Mosca M, Ramsey-Goldman R, Smolen JS, Wofsy D, Boumpas DT, Kamen DL, Jayne D, Cervera R, Costedoat-Chalumeau N, Diamond B, Gladman DD, Hahn B, Hiepe F, Jacobsen S, Khanna D, Lerstrøm K, Massarotti E, McCune J, Ruiz-Irastorza G, Sanchez-Guerrero J, Schneider M, Urowitz M, Bertsias G, Hoyer BF, Leuchten N, Tani C, Tedeschi SK, Touma Z, Schmajuk G, Anic B, Assan F, Chan TM, Clarke AE, Crow MK, Czirják L, Doria A, Graninger W, Halda-Kiss B, Hasni S, Izmirly PM, Jung M, Kumánovics G, Mariette X, Padjen I, Pego-Reigosa JM, Romero-Diaz J, Rúa-Figueroa Fernández Í, Seror R, Stummvoll GH, Tanaka Y, Tektonidou MG, Vasconcelos C, Vital EM, Wallace DJ, Yavuz S, Meroni PL, Fritzler MJ, Naden R, Dörner T, Johnson SR. 2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus. Arthritis Rheumatol. 2019 Aug 06. PMID: 31385462.
      View in: PubMed
    2. Aringer M, Costenbader K, Daikh D, Brinks R, Mosca M, Ramsey-Goldman R, Smolen JS, Wofsy D, Boumpas DT, Kamen DL, Jayne D, Cervera R, Costedoat-Chalumeau N, Diamond B, Gladman DD, Hahn B, Hiepe F, Jacobsen S, Khanna D, Lerstrøm K, Massarotti E, McCune J, Ruiz-Irastorza G, Sanchez-Guerrero J, Schneider M, Urowitz M, Bertsias G, Hoyer BF, Leuchten N, Tani C, Tedeschi SK, Touma Z, Schmajuk G, Anic B, Assan F, Chan TM, Clarke AE, Crow MK, Czirják L, Doria A, Graninger W, Halda-Kiss B, Hasni S, Izmirly PM, Jung M, Kumánovics G, Mariette X, Padjen I, Pego-Reigosa JM, Romero-Diaz J, Rúa-Figueroa Fernández Í, Seror R, Stummvoll GH, Tanaka Y, Tektonidou MG, Vasconcelos C, Vital EM, Wallace DJ, Yavuz S, Meroni PL, Fritzler MJ, Naden R, Dörner T, Johnson SR. 2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus. Ann Rheum Dis. 2019 Sep; 78(9):1151-1159. PMID: 31383717.
      View in: PubMed
    3. Daikh DI. ANA and lupus. Label vs Meaning. Arthritis Care Res (Hoboken). 2019 May 06. PMID: 31058455.
      View in: PubMed
    4. Daikh DI. Presidential Address. Arthritis Rheumatol. 2019 Jan 30. PMID: 30698363.
      View in: PubMed
    5. Tedeschi SK, Johnson SR, Boumpas DT, Daikh D, Dörner T, Diamond B, Jacobsen S, Jayne D, Kamen DL, McCune WJ, Mosca M, Ramsey-Goldman R, Ruiz-Irastorza G, Schneider M, Urowitz M, Wofsy D, Smolen JS, Naden RP, Aringer M, Costenbader KH. Multicriteria decision analysis process to develop new classification criteria for systemic lupus erythematosus. Ann Rheum Dis. 2019 May; 78(5):634-640. PMID: 30692164.
      View in: PubMed
    6. Johnson SR, Khanna D, Daikh D, Cervera R, Costedoat-Chalumeau N, Gladman DD, Hahn BH, Hiepe F, Sánchez-Guerrero J, Massarotti E, Boumpas DT, Costenbader KH, Jayne D, Dörner T, Kamen DL, Mosca M, Ramsey-Goldman R, Smolen JS, Wofsy D, Aringer M. Use of Consensus Methodology to Determine Candidate Items for Systemic Lupus Erythematosus Classification Criteria. J Rheumatol. 2019 Jul; 46(7):721-726. PMID: 30554156.
      View in: PubMed
    7. Schmajuk G, Hoyer BF, Aringer M, Johnson SR, Daikh DI, Dörner T. Multicenter Delphi Exercise to Identify Important Key Items for Classifying Systemic Lupus Erythematosus. Arthritis Care Res (Hoboken). 2018 Oct; 70(10):1488-1494. PMID: 29287313.
      View in: PubMed
    8. Aringer M, Daikh DI. How should we consider Lupus without ANA? Arthritis Care Res (Hoboken). 2018 Jul 23. PMID: 30035362.
      View in: PubMed
    9. van der Heijde D, Daikh DI, Betteridge N, Burmester GR, Hassett AL, Matteson EL, van Vollenhoven R, Lakhanpal S. Common language description of the term rheumatic and musculoskeletal diseases (RMDs) for use in communication with the lay public, healthcare providers and other stakeholders endorsed by the European League Against Rheumatism (EULAR) and the American College of Rheumatology (ACR). Ann Rheum Dis. 2018 Jun; 77(6):829-832. PMID: 29525777.
      View in: PubMed
    10. van der Heijde D, Daikh DI, Betteridge N, Burmester GR, Hassett AL, Matteson EL, van Vollenhoven R, Lakhanpal S. Common Language Description of the Term Rheumatic and Musculoskeletal Diseases (RMDs) for Use in Communication With the Lay Public, Healthcare Providers, and Other Stakeholders Endorsed by the European League Against Rheumatism (EULAR) and the American College of Rheumatology (ACR). Arthritis Rheumatol. 2018 Jun; 70(6):826-831. PMID: 29532625.
      View in: PubMed
    11. Tedeschi SK, Johnson SR, Boumpas D, Daikh D, Dörner T, Jayne D, Kamen D, Lerstrøm K, Mosca M, Ramsey-Goldman R, Sinnette C, Wofsy D, Smolen JS, Naden RP, Aringer M, Costenbader KH. Developing and Refining New Candidate Criteria for Systemic Lupus Erythematosus Classification: An International Collaboration. Arthritis Care Res (Hoboken). 2018 04; 70(4):571-581. PMID: 28692774.
      View in: PubMed
    12. Leuchten N, Hoyer A, Brinks R, Schoels M, Schneider M, Smolen J, Johnson SR, Daikh D, Dörner T, Aringer M, Bertsias G. Performance of Antinuclear Antibodies for Classifying Systemic Lupus Erythematosus: A Systematic Literature Review and Meta-Regression of Diagnostic Data. Arthritis Care Res (Hoboken). 2018 03; 70(3):428-438. PMID: 28544593.
      View in: PubMed
    13. Daikh DI, Costenbader KH. How Do We Classify "Incomplete Lupus?" Arthritis Care Res (Hoboken). 2017 Dec; 69(12):1777-1779. PMID: 28118516.
      View in: PubMed
    14. Schmajuk G, Tonner C, Miao Y, Yazdany J, Gannon J, Boscardin WJ, Daikh DI, Steinman MA. Folic Acid Supplementation Is Suboptimal in a National Cohort of Older Veterans Receiving Low Dose Oral Methotrexate. PLoS One. 2016; 11(12):e0168369. PMID: 27977768.
      View in: PubMed
    15. Andrews JS, Trupin L, Hough CL, Daikh DI, Yelin EH, Katz PP. Serum biomarkers of inflammation and muscle strength among women with systemic lupus erythematosus. Cytokine. 2017 02; 90:109-112. PMID: 27863333.
      View in: PubMed
    16. Bays A, Wahl E, Daikh DI, Yazdany J, Schmajuk G. Implementation of disease activity measurement for rheumatoid arthritis patients in an academic rheumatology clinic. BMC Health Serv Res. 2016 08 15; 16(a):384. PMID: 27527720; PMCID: PMC4986364.
    17. Daikh DI, Chen PP. Advances in managing ankylosing spondylitis. F1000Prime Rep. 2014; 6:78. PMID: 25343035; PMCID: PMC4166936.
    18. Schmajuk G, Miao Y, Yazdany J, Boscardin WJ, Daikh DI, Steinman MA. Identification of risk factors for elevated transaminases in methotrexate users through an electronic health record. Arthritis Care Res (Hoboken). 2014 Aug; 66(8):1159-66. PMID: 24470205; PMCID: PMC4112168.
    19. Yazdany J, Schmajuk G, Robbins M, Daikh D, Beall A, Yelin E, Barton J, Carlson A, Margaretten M, Zell J, Gensler LS, Kelly V, Saag K, King C. Choosing wisely: the American College of Rheumatology's Top 5 list of things physicians and patients should question. Arthritis Care Res (Hoboken). 2013 Mar; 65(3):329-39. PMID: 23436818.
      View in: PubMed
    20. Mohr DC, Lovera J, Brown T, Cohen B, Neylan T, Henry R, Siddique J, Jin L, Daikh D, Pelletier D. A randomized trial of stress management for the prevention of new brain lesions in MS. Neurology. 2012 Jul 31; 79(5):412-9. PMID: 22786596; PMCID: PMC3405245.
    21. Hahn BH, McMahon MA, Wilkinson A, Wallace WD, Daikh DI, Fitzgerald JD, Karpouzas GA, Merrill JT, Wallace DJ, Yazdany J, Ramsey-Goldman R, Singh K, Khalighi M, Choi SI, Gogia M, Kafaja S, Kamgar M, Lau C, Martin WJ, Parikh S, Peng J, Rastogi A, Chen W, Grossman JM. American College of Rheumatology guidelines for screening, treatment, and management of lupus nephritis. Arthritis Care Res (Hoboken). 2012 Jun; 64(6):797-808. PMID: 22556106; PMCID: PMC3437757.
    22. Daikh DI, St Clair EW. Updated recommendations for the treatment of rheumatoid arthritis: another step on a long road. Arthritis Care Res (Hoboken). 2012 May; 64(5):648-51. PMID: 22473919; PMCID: PMC4097090.
    23. Ashouri JF, Daikh DI. Rheumatic manifestations of cancer. Rheum Dis Clin North Am. 2011 Nov; 37(4):489-505. PMID: 22075194.
      View in: PubMed
    24. Charles JF, Eberle C, Daikh DI, Rooney T. Resolution of recurrent fusarium arthritis after prolonged antifungal therapy. J Clin Rheumatol. 2011 Jan; 17(1):44-5. PMID: 21169847.
      View in: PubMed
    25. Scalapino KJ, Daikh DI. Suppression of glomerulonephritis in NZB/NZW lupus prone mice by adoptive transfer of ex vivo expanded regulatory T cells. PLoS One. 2009 Jun 24; 4(6):e6031. PMID: 19551149; PMCID: PMC2696596.
    26. Gupta VA, Hermiston ML, Cassafer G, Daikh DI, Weiss A. B cells drive lymphocyte activation and expansion in mice with the CD45 wedge mutation and Fas deficiency. J Exp Med. 2008 Nov 24; 205(12):2755-61. PMID: 19001138; PMCID: PMC2585841.
    27. Scalapino KJ, Daikh DI. CTLA-4: a key regulatory point in the control of autoimmune disease. Immunol Rev. 2008 Jun; 223:143-55. PMID: 18613834.
      View in: PubMed
    28. Bahjat FR, Pine PR, Reitsma A, Cassafer G, Baluom M, Grillo S, Chang B, Zhao FF, Payan DG, Grossbard EB, Daikh DI. An orally bioavailable spleen tyrosine kinase inhibitor delays disease progression and prolongs survival in murine lupus. Arthritis Rheum. 2008 May; 58(5):1433-44. PMID: 18438845.
      View in: PubMed
    29. Kinder BW, Collard HR, Koth L, Daikh DI, Wolters PJ, Elicker B, Jones KD, King TE. Idiopathic nonspecific interstitial pneumonia: lung manifestation of undifferentiated connective tissue disease? Am J Respir Crit Care Med. 2007 Oct 01; 176(7):691-7. PMID: 17556720; PMCID: PMC1994238.
    30. Buxbaum J, Qian P, Khuu C, Shneider BL, Daikh DI, Gershwin ME, Allen PM, Peters MG. Novel model of antigen-specific induction of bile duct injury. Gastroenterology. 2006 Dec; 131(6):1899-906. PMID: 17087941; PMCID: PMC4113411.
    31. Scalapino KJ, Tang Q, Bluestone JA, Bonyhadi ML, Daikh DI. Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells. J Immunol. 2006 Aug 01; 177(3):1451-9. PMID: 16849451.
      View in: PubMed
    32. Daikh DI, Gillis J, Wofsy D. Inhibition of T cell costimulation: an emerging therapeutic strategy for autoimmune rheumatic diseases. Arthritis Rheum. 2006 Apr 15; 55(2):322-4. PMID: 16583382.
      View in: PubMed
    33. Daikh DI. The Vioxx debacle revisited. Am J Med. 2005 Sep; 118(9):1057. PMID: 16164908.
      View in: PubMed
    34. Cunnane G, Chan OT, Cassafer G, Brindis S, Kaufman E, Yen TS, Daikh DI. Prevention of renal damage in murine lupus nephritis by CTLA-4Ig and cyclophosphamide. Arthritis Rheum. 2004 May; 50(5):1539-48. PMID: 15146424.
      View in: PubMed
    35. Cunnane G, Warnock M, Fye KH, Daikh DI. Accelerated nodulosis and vasculitis following etanercept therapy for rheumatoid arthritis. Arthritis Rheum. 2002 Aug; 47(4):445-9. PMID: 12209493.
      View in: PubMed
    36. Schumacher HR, Boice JA, Daikh DI, Mukhopadhyay S, Malmstrom K, Ng J, Tate GA, Molina J. Randomised double blind trial of etoricoxib and indometacin in treatment of acute gouty arthritis. BMJ. 2002 Jun 22; 324(7352):1488-92. PMID: 12077033; PMCID: PMC116444.
    37. Wofsy D, Daikh DI. Treatment of autoimmune diseases by inhibition of T-cell costimulation. Mod Rheumatol. 2002 Mar; 12(1):1-4. PMID: 24383824.
      View in: PubMed
    38. Daikh DI, Wofsy D. Cutting edge: reversal of murine lupus nephritis with CTLA4Ig and cyclophosphamide. J Immunol. 2001 Mar 01; 166(5):2913-6. PMID: 11207238.
      View in: PubMed
    39. Daikh DI, Wofsy D. Treatment of autoimmunity by inhibition of T cell costimulation. Adv Exp Med Biol. 2001; 490:113-7. PMID: 11505969.
      View in: PubMed
    40. Majeti R, Xu Z, Parslow TG, Olson JL, Daikh DI, Killeen N, Weiss A. An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity. Cell. 2000 Dec 22; 103(7):1059-70. PMID: 11163182.
      View in: PubMed
    41. Daikh DI, Wofsy D. Effects of anti-B7 monoclonal antibodies on humoral immune responses. J Autoimmun. 1999 Mar; 12(2):101-8. PMID: 10047430.
      View in: PubMed
    42. Daikh DI, Wofsy D. On the horizon: clinical trials of new immunosuppressive strategies for autoimmune diseases. Transplant Proc. 1998 Dec; 30(8):4027-8. PMID: 9865285.
      View in: PubMed
    43. Wofsy D, Daikh DI. Opportunities for future biological therapy in SLE. Baillieres Clin Rheumatol. 1998 Aug; 12(3):529-41. PMID: 9890111.
      View in: PubMed
    44. Daikh DI, Finck BK, Linsley PS, Hollenbaugh D, Wofsy D. Long-term inhibition of murine lupus by brief simultaneous blockade of the B7/CD28 and CD40/gp39 costimulation pathways. J Immunol. 1997 Oct 01; 159(7):3104-8. PMID: 9317105.
      View in: PubMed