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John Imboden, JR, MD

Title(s)Professor Emeritus, Medicine
SchoolSchool of Medicine
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    Collapse Research 
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    Immunodominant Epitopes in Kawasaki Disease
    NIH/NHLBI R21HL087905Sep 30, 2007 - Jun 30, 2010
    Role: Principal Investigator
    MUTATIONAL ANALYSIS OF CTLA-4 FUNCTION IN VIVO
    NIH/NIAID R03AI043962Sep 30, 1999 - Aug 31, 2003
    Role: Principal Investigator
    MYCOBACTERIUM TUBERCULOSIS;INDUCED MACROPHAGE SIGNALLING
    NIH/NHLBI R01HL051992Sep 30, 1993 - Aug 31, 2003
    Role: Principal Investigator
    GP35--A SIGNAL TRANSDUCER ON NK CELL
    NIH/NCI R01CA052669Aug 6, 1990 - May 31, 1995
    Role: Principal Investigator
    COSTIMULATION OF T LYMPHOCYTES OF CD28
    NIH/NIAID R01AI026644Aug 1, 1988 - Jun 30, 2005
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Shimizu T, Cruz A, Tanaka M, Mamoto K, Pedoia V, Burghardt AJ, Heilmeier U, Link TM, Graf J, Imboden JB, Li X. Structural Changes over a Short Period Are Associated with Functional Assessments in Rheumatoid Arthritis. J Rheumatol. 2019 Jul; 46(7):676-684. PMID: 30770506.
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    2. Graf J, Imboden J. Vasculitis and peripheral neuropathy. Curr Opin Rheumatol. 2019 01; 31(1):40-45. PMID: 30461543.
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    3. Gianfrancesco MA, Trupin L, Shiboski S, van der Laan M, Graf J, Imboden J, Yazdany J, Schmajuk G. Smoking Is Associated with Higher Disease Activity in Rheumatoid Arthritis: A Longitudinal Study Controlling for Time-varying Covariates. J Rheumatol. 2019 Apr; 46(4):370-375. PMID: 30504507.
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    4. Wysham KD, Shoback DM, Imboden JB, Katz PP. Association of High Anti-Cyclic Citrullinated Peptide Seropositivity and Lean Mass Index With Low Bone Mineral Density in Rheumatoid Arthritis. Arthritis Care Res (Hoboken). 2018 07; 70(7):961-969. PMID: 29106028.
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    5. Mok A, Rhead B, Holingue C, Shao X, Quach HL, Quach D, Sinclair E, Graf J, Imboden J, Link T, Harrison R, Chernitskiy V, Barcellos LF, Criswell LA. Hypomethylation of CYP2E1 and DUSP22 Promoters Associated With Disease Activity and Erosive Disease Among Rheumatoid Arthritis Patients. Arthritis Rheumatol. 2018 04; 70(4):528-536. PMID: 29287311.
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    6. Goglin SE, Imboden JB. Neurologic Manifestations of Rheumatic Diseases. Rheum Dis Clin North Am. 2017 Nov; 43(4):xiii-xiv. PMID: 29061250.
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    7. Sarah E. Goglin, John B. Imboden. Neurologic Manifestations of Rheumatic Diseases. Rheumatic Disease Clinics of North America. 2017 Nov 1; 43(4):i.
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    8. Shimizu T, Choi HJ, Heilmeier U, Tanaka M, Burghardt AJ, Gong J, Chanchek N, Link TM, Graf J, Imboden JB, Li X. Assessment of 3-month changes in bone microstructure under anti-TNFa therapy in patients with rheumatoid arthritis using high-resolution peripheral quantitative computed tomography (HR-pQCT). Arthritis Res Ther. 2017 Oct 04; 19(1):222. PMID: 28978352.
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    9. DeQuattro K, Imboden JB. Neurologic Manifestations of Rheumatoid Arthritis. Rheum Dis Clin North Am. 2017 11; 43(4):561-571. PMID: 29061242.
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    10. Imboden JB. Involvement of the Peripheral Nervous System in Polyarteritis Nodosa and Antineutrophil Cytoplasmic Antibodies-Associated Vasculitis. Rheum Dis Clin North Am. 2017 11; 43(4):633-639. PMID: 29061248.
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    11. Malmstroem S, Rejnmark L, Imboden JB, Shoback DM, Bikle DD. Current Assays to Determine Free 25-Hydroxyvitamin D in Serum. J AOAC Int. 2017 Sep 01; 100(5):1323-1327. PMID: 28492133.
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    12. Ku E, Pedoia V, Tanaka M, Heilmeier U, Imboden J, Graf J, Link T, Li X. Evaluating radiocarpal cartilage matrix changes 3-months after anti-TNF treatment for rheumatoid arthritis using MR T1? imaging. J Magn Reson Imaging. 2017 05; 45(5):1514-1522. PMID: 27661002.
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    13. Barton JL, Trupin L, Schillinger D, Evans-Young G, Imboden J, Montori VM, Yelin E. Use of Low-Literacy Decision Aid to Enhance Knowledge and Reduce Decisional Conflict Among a Diverse Population of Adults With Rheumatoid Arthritis: Results of a Pilot Study. Arthritis Care Res (Hoboken). 2016 07; 68(7):889-98. PMID: 26605752.
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    14. H. Choi, U. Heilmeier, M. Tanaka, A.J. Burghardt, N. Chanchek, T.M. Link, J. Graft, J.B. Imboden, X. Li. SAT0545 The Effect of anti-TNF Alpha Treatment on Erosion Progression in Rheumatoid Arthritis by High-Resolution Peripheral Quantitative Computed Tomography: Three-Month Data. Annals of the Rheumatic Diseases. 2016 Jun 1; 75(Suppl 2):866.
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    15. Liu J, Pedoia V, Heilmeier U, Ku E, Su F, Khanna S, Imboden J, Graf J, Link T, Li X. High-temporospatial-resolution dynamic contrast-enhanced (DCE) wrist MRI with variable-density pseudo-random circular Cartesian undersampling (CIRCUS) acquisition: evaluation of perfusion in rheumatoid arthritis patients. NMR Biomed. 2016 Jan; 29(1):15-23. PMID: 26608949.
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    16. Scheibe MM, Imboden JB, Schmajuk G, Margaretten M, Graf JD, Chen AH, Yelin EH, Yazdany J. Efficiency Gains for Rheumatology Consultation Using a Novel Electronic Referral System in a Safety-Net Health Setting. Arthritis Care Res (Hoboken). 2015 Aug; 67(8):1158-63. PMID: 25623810.
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    17. Hellmann DB, Imboden JB. Update in rheumatology: evidence published in 2014. Ann Intern Med. 2015 May 05; 162(9):W122-6. PMID: 25927977.
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    18. Yang H, Yu A, Burghardt AJ, Virayavanich W, Link TM, Imboden JB, Li X. Quantitative characterization of metacarpal and radial bone in rheumatoid arthritis using high resolution- peripheral quantitative computed tomography. Int J Rheum Dis. 2017 Mar; 20(3):353-362. PMID: 25865349.
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    19. Yang H, Rivoire J, Hoppe M, Srikhum W, Imboden J, Link TM, Li X. Computer-aided and manual quantifications of MRI synovitis, bone marrow edema-like lesions, erosion and cartilage loss in rheumatoid arthritis of the wrist. Skeletal Radiol. 2015 Apr; 44(4):539-47. PMID: 25488101.
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    20. Hsue PY, Scherzer R, Grunfeld C, Imboden J, Wu Y, Del Puerto G, Nitta E, Shigenaga J, Schnell Heringer A, Ganz P, Graf J. Depletion of B-cells with rituximab improves endothelial function and reduces inflammation among individuals with rheumatoid arthritis. J Am Heart Assoc. 2014 Oct 21; 3(5):e001267. PMID: 25336464.
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    21. Lee CH, Srikhum W, Burghardt AJ, Virayavanich W, Imboden JB, Link TM, Li X. Correlation of structural abnormalities of the wrist and metacarpophalangeal joints evaluated by high-resolution peripheral quantitative computed tomography, 3 Tesla magnetic resonance imaging and conventional radiographs in rheumatoid arthritis. Int J Rheum Dis. 2015 Jul; 18(6):628-39. PMID: 25293500.
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    22. Carlson AQ, Tuot DS, Jen KY, Butcher B, Graf J, Sam R, Imboden JB. Pauci-immune glomerulonephritis in individuals with disease associated with levamisole-adulterated cocaine: a series of 4 cases. Medicine (Baltimore). 2014 Oct; 93(17):290-7. PMID: 25398064.
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    23. Teruel JR, Burghardt AJ, Rivoire J, Srikhum W, Noworolski SM, Link TM, Imboden JB, Li X. Bone structure and perfusion quantification of bone marrow edema pattern in the wrist of patients with rheumatoid arthritis: a multimodality study. J Rheumatol. 2014 Sep; 41(9):1766-73. PMID: 25086074.
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    24. Barton JL, Trupin L, Tonner C, Imboden J, Katz P, Schillinger D, Yelin E. English language proficiency, health literacy, and trust in physician are associated with shared decision making in rheumatoid arthritis. J Rheumatol. 2014 Jul; 41(7):1290-7. PMID: 24931952.
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    25. Coffey G, Betz A, Graf J, Stephens G, Hua Lin P, Imboden J, Sinha U. Methotrexate and a spleen tyrosine kinase inhibitor cooperate to inhibit responses to peripheral blood B cells in rheumatoid arthritis. Pharmacol Res Perspect. 2013 Dec; 1(2):e00016. PMID: 25505569.
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    26. Burghardt AJ, Lee CH, Kuo D, Majumdar S, Imboden JB, Link TM, Li X. Quantitative in vivo HR-pQCT imaging of 3D wrist and metacarpophalangeal joint space width in rheumatoid arthritis. Ann Biomed Eng. 2013 Dec; 41(12):2553-64. PMID: 23887879.
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    27. Richman NC, Yazdany J, Graf J, Chernitskiy V, Imboden JB. Extraarticular manifestations of rheumatoid arthritis in a multiethnic cohort of predominantly Hispanic and Asian patients. Medicine (Baltimore). 2013 Mar; 92(2):92-7. PMID: 23429352.
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    28. Srikhum W, Virayavanich W, Burghardt AJ, Yu A, Link TM, Imboden JB, Li X. Quantitative and semiquantitative bone erosion assessment on high-resolution peripheral quantitative computed tomography in rheumatoid arthritis. J Rheumatol. 2013 Apr; 40(4):408-16. PMID: 23418386.
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    29. Barton JL, Schmajuk G, Trupin L, Graf J, Imboden J, Yelin EH, Schillinger D. Poor knowledge of methotrexate associated with older age and limited English-language proficiency in a diverse rheumatoid arthritis cohort. Arthritis Res Ther. 2013; 15(5):R157. PMID: 24432366.
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    30. Bajpai UD, Swainson LA, Mold JE, Graf JD, Imboden JB, McCune JM. A functional variant in FCRL3 is associated with higher Fc receptor-like 3 expression on T cell subsets and rheumatoid arthritis disease activity. Arthritis Rheum. 2012 Aug; 64(8):2451-9. PMID: 22392608.
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    31. Priscilla Hsue, Carl Grunfeld, John Imboden, Yuaner Wu, Rebecca Scherzer, Saira Mohammed, Gus del Puerto, Amanda Schnell Heringer, Peter Ganz, Jonathan Graf. DEPLETION OF B-CELLS WITH RITUXIMAB IMPROVES ENDOTHELIAL FUNCTION AND REDUCES INFLAMMATION AMONG INDIVIDUALS WITH RHEUMATOID ARTHRITIS. Journal of the American College of Cardiology. 2012 Mar 1; 59(13):e1540.
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    32. Graf J, Lynch K, Yeh CL, Tarter L, Richman N, Nguyen T, Kral A, Dominy S, Imboden J. Purpura, cutaneous necrosis, and antineutrophil cytoplasmic antibodies associated with levamisole-adulterated cocaine. Arthritis Rheum. 2011 Dec; 63(12):3998-4001. PMID: 22127712.
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    33. Li X, Yu A, Virayavanich W, Noworolski SM, Link TM, Imboden J. Quantitative characterization of bone marrow edema pattern in rheumatoid arthritis using 3 Tesla MRI. J Magn Reson Imaging. 2012 Jan; 35(1):211-7. PMID: 21987483.
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    34. Barton JL, Trupin L, Schillinger D, Gansky SA, Tonner C, Margaretten M, Chernitskiy V, Graf J, Imboden J, Yelin E. Racial and ethnic disparities in disease activity and function among persons with rheumatoid arthritis from university-affiliated clinics. Arthritis Care Res (Hoboken). 2011 Sep; 63(9):1238-46. PMID: 21671414.
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    35. Rooney T, Scherzer R, Shigenaga JK, Graf J, Imboden JB, Grunfeld C. Levels of plasma fibrinogen are elevated in well-controlled rheumatoid arthritis. Rheumatology (Oxford). 2011 Aug; 50(8):1458-65. PMID: 21441551.
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    36. Margaretten M, Barton J, Julian L, Katz P, Trupin L, Tonner C, Graf J, Imboden J, Yelin E. Socioeconomic determinants of disability and depression in patients with rheumatoid arthritis. Arthritis Care Res (Hoboken). 2011 Feb; 63(2):240-6. PMID: 20824800.
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    37. Gratton SB, Imboden JB. A 23-year-old woman with fever, rash, and arthritis. Arthritis Care Res (Hoboken). 2010 Oct; 62(10):1507-12. PMID: 20506489.
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    38. Barton JL, Imboden J, Graf J, Glidden D, Yelin EH, Schillinger D. Patient-physician discordance in assessments of global disease severity in rheumatoid arthritis. Arthritis Care Res (Hoboken). 2010 Jun; 62(6):857-64. PMID: 20535797.
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    39. Margaretten M, Yelin E, Imboden J, Graf J, Barton J, Katz P, Julian L. Predictors of depression in a multiethnic cohort of patients with rheumatoid arthritis. Arthritis Rheum. 2009 Nov 15; 61(11):1586-91. PMID: 19877099.
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    40. Graf J, Scherzer R, Grunfeld C, Imboden J. Levels of C-reactive protein associated with high and very high cardiovascular risk are prevalent in patients with rheumatoid arthritis. PLoS One. 2009 Jul 16; 4(7):e6242. PMID: 19606218.
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    41. Ku IA, Imboden JB, Hsue PY, Ganz P. Rheumatoid arthritis: model of systemic inflammation driving atherosclerosis. Circ J. 2009 Jun; 73(6):977-85. PMID: 19430165.
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    42. Imboden JB. The immunopathogenesis of rheumatoid arthritis. Annu Rev Pathol. 2009; 4:417-34. PMID: 18954286.
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    43. Hellmann DB, Imboden JB. Update in rheumatology. Ann Intern Med. 2006 Dec 05; 145(11):834-8. PMID: 17146068.
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    44. Sadra A, Cinek T, Imboden JB. Translocation of CD28 to lipid rafts and costimulation of IL-2. Proc Natl Acad Sci U S A. 2004 Aug 03; 101(31):11422-7. PMID: 15280538.
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    45. Andres PG, Howland KC, Nirula A, Kane LP, Barron L, Dresnek D, Sadra A, Imboden J, Weiss A, Abbas AK. Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation. Nat Immunol. 2004 Apr; 5(4):435-42. PMID: 15004555.
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    46. Chikuma S, Imboden JB, Bluestone JA. Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4. J Exp Med. 2003 Jan 06; 197(1):129-35. PMID: 12515820.
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    47. Imboden JB, Shoback DM, Inokuchi S. Analysis of inositol phospholipid turnover during lymphocyte activation. Curr Protoc Immunol. 2001 May; Chapter 11:Unit 11.1. PMID: 18432702.
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    48. Sadra A, Cinek T, Imboden JB. Multiple probing of an immunoblot membrane using a non-block technique: advantages in speed and sensitivity. Anal Biochem. 2000 Feb 15; 278(2):235-7. PMID: 10660470.
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    49. Cinek T, Sadra A, Imboden JB. Cutting edge: tyrosine-independent transmission of inhibitory signals by CTLA-4. J Immunol. 2000 Jan 01; 164(1):5-8. PMID: 10604984.
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    50. Sadra A, Cinek T, Arellano JL, Shi J, Truitt KE, Imboden JB. Identification of tyrosine phosphorylation sites in the CD28 cytoplasmic domain and their role in the costimulation of Jurkat T cells. J Immunol. 1999 Feb 15; 162(4):1966-73. PMID: 9973466.
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    51. Barz C, Nagel T, Truitt KE, Imboden JB. Mutational analysis of CD28-mediated costimulation of Jun-N-terminal kinase and IL-2 production. J Immunol. 1998 Nov 15; 161(10):5366-72. PMID: 9820510.
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    52. Lu Y, Cuevas B, Gibson S, Khan H, LaPushin R, Imboden J, Mills GB. Phosphatidylinositol 3-kinase is required for CD28 but not CD3 regulation of the TEC family tyrosine kinase EMT/ITK/TSK: functional and physical interaction of EMT with phosphatidylinositol 3-kinase. J Immunol. 1998 Nov 15; 161(10):5404-12. PMID: 9820515.
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    53. Weber JR, Orstavik S, Torgersen KM, Danbolt NC, Berg SF, Ryan JC, Taskén K, Imboden JB, Vaage JT. Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells. J Exp Med. 1998 Apr 06; 187(7):1157-61. PMID: 9529333.
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    54. Gibson S, Truitt K, Lu Y, Lapushin R, Khan H, Imboden JB, Mills GB. Efficient CD28 signalling leads to increases in the kinase activities of the TEC family tyrosine kinase EMT/ITK/TSK and the SRC family tyrosine kinase LCK. Biochem J. 1998 Mar 15; 330 ( Pt 3):1123-8. PMID: 9494076.
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    55. Daikh D, Wofsy D, Imboden JB. The CD28-B7 costimulatory pathway and its role in autoimmune disease. J Leukoc Biol. 1997 Aug; 62(2):156-62. PMID: 9261329.
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    56. Shapiro VS, Truitt KE, Imboden JB, Weiss A. CD28 mediates transcriptional upregulation of the interleukin-2 (IL-2) promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites. Mol Cell Biol. 1997 Jul; 17(7):4051-8. PMID: 9199340.
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    57. Shi J, Cinek T, Truitt KE, Imboden JB. Wortmannin, a phosphatidylinositol 3-kinase inhibitor, blocks antigen-mediated, but not CD3 monoclonal antibody-induced, activation of murine CD4+ T cells. J Immunol. 1997 May 15; 158(10):4688-95. PMID: 9144481.
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    58. Imboden J. Turning off natural killers. Innate immunity. Curr Biol. 1996 Sep 01; 6(9):1070-2. PMID: 8805356.
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    59. Truitt KE, Nagel T, Suen LF, Imboden JB. Structural requirements for CD28-mediated costimulation of IL-2 production in Jurkat T cells. J Immunol. 1996 Jun 15; 156(12):4539-41. PMID: 8648094.
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    60. Bell GM, Fargnoli J, Bolen JB, Kish L, Imboden JB. The SH3 domain of p56lck binds to proline-rich sequences in the cytoplasmic domain of CD2. J Exp Med. 1996 Jan 01; 183(1):169-78. PMID: 8551220.
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    61. Truitt KE, Shi J, Gibson S, Segal LG, Mills GB, Imboden JB. CD28 delivers costimulatory signals independently of its association with phosphatidylinositol 3-kinase. J Immunol. 1995 Nov 15; 155(10):4702-10. PMID: 7594470.
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    62. Imboden JB, Koretsky GA. Intracellular signalling. Switching off signals. Curr Biol. 1995 Jul 01; 5(7):727-9. PMID: 7583115.
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    63. Sánchez-Margalet V, Goldfine ID, Truitt K, Imboden J, Sung CK. Role of p85 subunit of phosphatidylinositol-3-kinase as an adaptor molecule linking the insulin receptor to insulin receptor substrate 1. Mol Endocrinol. 1995 Apr; 9(4):435-42. PMID: 7659087.
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    64. Truitt KE, Hicks CM, Imboden JB. Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells. J Exp Med. 1994 Mar 01; 179(3):1071-6. PMID: 7509360.
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    65. Bell GM, Dethloff GM, Imboden JB. CD45-negative mutants of a rat natural killer cell line fail to lyse tumor target cells. J Immunol. 1993 Oct 01; 151(7):3646-53. PMID: 8104222.
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    66. Bell GM, Bolen JB, Imboden JB. Association of Src-like protein tyrosine kinases with the CD2 cell surface molecule in rat T lymphocytes and natural killer cells. Mol Cell Biol. 1992 Dec; 12(12):5548-54. PMID: 1280324.
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    67. Weber JR, Bell GM, Han MY, Pawson T, Imboden JB. Association of the tyrosine kinase LCK with phospholipase C-gamma 1 after stimulation of the T cell antigen receptor. J Exp Med. 1992 Aug 01; 176(2):373-9. PMID: 1500851.
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    68. Bell GM, Seaman WE, Niemi EC, Imboden JB. The OX-44 molecule couples to signaling pathways and is associated with CD2 on rat T lymphocytes and a natural killer cell line. J Exp Med. 1992 Feb 01; 175(2):527-36. PMID: 1346273.
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    69. Goldfien RD, Seaman WE, Hempel WM, Imboden JB. Divergent regulation of phospholipase C-alpha and phospholipase C-gamma transcripts during activation of a human T cell line. J Immunol. 1991 Jun 01; 146(11):3703-8. PMID: 2033247.
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    70. Ledbetter JA, Schieven GL, Uckun FM, Imboden JB. CD45 cross-linking regulates phospholipase C activation and tyrosine phosphorylation of specific substrates in CD3/Ti-stimulated T cells. J Immunol. 1991 Mar 01; 146(5):1577-83. PMID: 1847166.
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    71. Seaman WE, Niemi EC, Stark MR, Goldfien RD, Pollock AS, Imboden JB. Molecular cloning of gp42, a cell-surface molecule that is selectively induced on rat natural killer cells by interleukin 2: glycolipid membrane anchoring and capacity for transmembrane signaling. J Exp Med. 1991 Jan 01; 173(1):251-60. PMID: 1845873.
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    72. Budd RC, Winslow G, Inokuchi S, Imboden JB. Intact antigen receptor-mediated generation of inositol phosphates and increased intracellular calcium in CD4 CD8 T lymphocytes from MRL lpr mice. J Immunol. 1990 Nov 01; 145(9):2862-72. PMID: 1976707.
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    73. Inokuchi S, Imboden JB. Antigen receptor-mediated regulation of sustained polyphosphoinositide turnover in a human T cell line. Evidence for a receptor-regulated pathway for production of phosphatidylinositol 4,5-bisphosphate. J Biol Chem. 1990 Apr 15; 265(11):5983-9. PMID: 2156835.
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    74. Ledbetter JA, Imboden JB, Schieven GL, Grosmaire LS, Rabinovitch PS, Lindsten T, Thompson CB, June CH. CD28 ligation in T-cell activation: evidence for two signal transduction pathways. Blood. 1990 Apr 01; 75(7):1531-9. PMID: 2156582.
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    75. Imboden JB, June CH, McCutcheon MA, Ledbetter JA. Stimulation of CD5 enhances signal transduction by the T cell antigen receptor. J Clin Invest. 1990 Jan; 85(1):130-4. PMID: 1688565.
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    76. Ledbetter JA, June CH, Rabinovitch PS, Grossmann A, Tsu TT, Imboden JB. Signal transduction through CD4 receptors: stimulatory vs. inhibitory activity is regulated by CD4 proximity to the CD3/T cell receptor. Eur J Immunol. 1988 Apr; 18(4):525-32. PMID: 2966739.
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    77. Bernard Manger, John Imboden, Arthur Weiss. Role of the T3/T-Cell Antigen Receptor Complex in T-Cell Activation. The T-Cell Receptors. 1988 Jan 1; 133-149.
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    78. John B. Imboden, Arthur Weiss. CHAPTER 4 REGULATION OF INTERLEUKIN 2 PRODUCTION BY THE T CELL ANTIGEN RECEPTOR. Interleukin. 1988 Jan 1; 85-98.
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    79. Imboden JB, Weiss A. The initiation of human T lymphocyte activation. Prog Allergy. 1988; 42:246-79. PMID: 2845427.
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    80. Imboden JB, Weiss A. The T-cell antigen receptor regulates sustained increases in cytoplasmic free Ca2+ through extracellular Ca2+ influx and ongoing intracellular Ca2+ mobilization. Biochem J. 1987 Nov 01; 247(3):695-700. PMID: 3426556.
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    81. Manger B, Weiss A, Imboden J, Laing T, Stobo JD. The role of protein kinase C in transmembrane signaling by the T cell antigen receptor complex. Effects of stimulation with soluble or immobilized CD3 antibodies. J Immunol. 1987 Oct 15; 139(8):2755-60. PMID: 3116093.
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    82. Imboden JB, Pattison G. Regulation of inositol 1,4,5-trisphosphate kinase activity after stimulation of human T cell antigen receptor. J Clin Invest. 1987 May; 79(5):1538-41. PMID: 3494750.
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    83. Weiss A, Shields R, Newton M, Manger B, Imboden J. Ligand-receptor interactions required for commitment to the activation of the interleukin 2 gene. J Immunol. 1987 Apr 01; 138(7):2169-76. PMID: 3104454.
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    84. Weiss A, Imboden JB. Cell surface molecules and early events involved in human T lymphocyte activation. Adv Immunol. 1987; 41:1-38. PMID: 2961214.
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    85. Weiss A, Imboden J, Hardy K, Stobo J. The role of the antigen receptor/T3 complex in T-cell activation. Adv Exp Med Biol. 1987; 213:45-9. PMID: 2957896.
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    86. Imboden JB, Shoback DM, Pattison G, Stobo JD. Cholera toxin inhibits the T-cell antigen receptor-mediated increases in inositol trisphosphate and cytoplasmic free calcium. Proc Natl Acad Sci U S A. 1986 Aug; 83(15):5673-7. PMID: 3016713.
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    87. Weiss A, Manger B, Imboden J. Synergy between the T3/antigen receptor complex and Tp44 in the activation of human T cells. J Immunol. 1986 Aug 01; 137(3):819-25. PMID: 3088111.
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    88. Weiss A, Imboden J, Hardy K, Manger B, Terhorst C, Stobo J. The role of the T3/antigen receptor complex in T-cell activation. Annu Rev Immunol. 1986; 4:593-619. PMID: 2939858.
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    89. Imboden JB, Weiss A, Stobo JD. Transmembrane signalling by the T3-antigen receptor complex. Immunol Today. 1985 Nov; 6(11):328-31. PMID: 25291003.
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    90. Wiskocil R, Weiss A, Imboden J, Kamin-Lewis R, Stobo J. Activation of a human T cell line: a two-stimulus requirement in the pretranslational events involved in the coordinate expression of interleukin 2 and gamma-interferon genes. J Immunol. 1985 Mar; 134(3):1599-603. PMID: 3918105.
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    91. Imboden JB, Stobo JD. Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores. J Exp Med. 1985 Mar 01; 161(3):446-56. PMID: 3919143.
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    92. Imboden JB, Weiss A, Stobo JD. The antigen receptor on a human T cell line initiates activation by increasing cytoplasmic free calcium. J Immunol. 1985 Feb; 134(2):663-5. PMID: 3871211.
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    93. Weiss A, Imboden J, Shoback D, Stobo J. Role of T3 surface molecules in human T-cell activation: T3-dependent activation results in an increase in cytoplasmic free calcium. Proc Natl Acad Sci U S A. 1984 Jul; 81(13):4169-73. PMID: 6234599.
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