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John Imboden, JR, MD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentMedicine
Address1001 Potrero Ave
San Francisco CA 94110
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    Collapse Research 
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    Immunodominant Epitopes in Kawasaki Disease
    NIH/NHLBI R21HL087905Sep 30, 2007 - Jun 30, 2010
    Role: Principal Investigator
    MUTATIONAL ANALYSIS OF CTLA-4 FUNCTION IN VIVO
    NIH/NIAID R03AI043962Sep 30, 1999 - Aug 31, 2003
    Role: Principal Investigator
    MYCOBACTERIUM TUBERCULOSIS;INDUCED MACROPHAGE SIGNALLING
    NIH/NHLBI R01HL051992Sep 30, 1993 - Aug 31, 2003
    Role: Principal Investigator
    GP35--A SIGNAL TRANSDUCER ON NK CELL
    NIH/NCI R01CA052669Aug 6, 1990 - May 31, 1995
    Role: Principal Investigator
    COSTIMULATION OF T LYMPHOCYTES OF CD28
    NIH/NIAID R01AI026644Aug 1, 1988 - Jun 30, 2005
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Shimizu T, Choi HJ, Heilmeier U, Tanaka M, Burghardt AJ, Gong J, Chanchek N, Link TM, Graf J, Imboden J, Li X. Assessment of 3-month changes in bone microstructure under anti-TNFa therapy in patients with rheumatoid arthritis using high-resolution peripheral quantitative computed tomography (HR-pQCT). Arthritis Res Ther. 2017 Oct 04; 19(1):222. PMID: 28978352.
      View in: PubMed
    2. Malmstroem S, Rejnmark L, Imboden J, Shoback DM, Bikle DD. Current Assays to Determine Free 25-Hydroxyvitamin D in Serum. J AOAC Int. 2017 Sep 01; 100(5):1323-1327. PMID: 28492133.
      View in: PubMed
    3. Ku E, Pedoia V, Tanaka M, Heilmeier U, Imboden J, Graf J, Link T, Li X, et al. Evaluating radiocarpal cartilage matrix changes 3-months after anti-TNF treatment for rheumatoid arthritis using MR T1? imaging. J Magn Reson Imaging. 2017 May; 45(5):1514-1522. PMID: 27661002.
      View in: PubMed
    4. Barton JL, Trupin L, Schillinger D, Evans-Young G, Imboden J, Montori VM, Yelin E. Use of Low-Literacy Decision Aid to Enhance Knowledge and Reduce Decisional Conflict Among a Diverse Population of Adults With Rheumatoid Arthritis: Results of a Pilot Study. Arthritis Care Res (Hoboken). 2016 Jul; 68(7):889-98. PMID: 26605752; PMCID: PMC4879097.
    5. Liu J, Pedoia V, Heilmeier U, Ku E, Su F, Khanna S, Imboden J, Graf J, Link T, Li X. High-temporospatial-resolution dynamic contrast-enhanced (DCE) wrist MRI with variable-density pseudo-random circular Cartesian undersampling (CIRCUS) acquisition: evaluation of perfusion in rheumatoid arthritis patients. NMR Biomed. 2016 Jan; 29(1):15-23. PMID: 26608949; PMCID: PMC4724417 [Available on 01/01/17].
    6. Scheibe MM, Imboden J, Schmajuk G, Margaretten M, Graf JD, Chen AH, Yelin EH, Yazdany J. Efficiency Gains for Rheumatology Consultation Using a Novel Electronic Referral System in a Safety-Net Health Setting. Arthritis Care Res (Hoboken). 2015 Aug; 67(8):1158-63. PMID: 25623810; PMCID: PMC4515392.
    7. Hellmann DB, Imboden J. Update in rheumatology: evidence published in 2014. Ann Intern Med. 2015 May 05; 162(9):W122-6. PMID: 25927977.
      View in: PubMed
    8. Yang H, Yu A, Burghardt AJ, Virayavanich W, Link TM, Imboden J, Li X. Quantitative characterization of metacarpal and radial bone in rheumatoid arthritis using high resolution- peripheral quantitative computed tomography. Int J Rheum Dis. 2017 Mar; 20(3):353-362. PMID: 25865349.
      View in: PubMed
    9. Yang H, Rivoire J, Hoppe M, Srikhum W, Imboden J, Link TM, Li X. Computer-aided and manual quantifications of MRI synovitis, bone marrow edema-like lesions, erosion and cartilage loss in rheumatoid arthritis of the wrist. Skeletal Radiol. 2015 Apr; 44(4):539-47. PMID: 25488101.
      View in: PubMed
    10. Hsue PY, Scherzer R, Grunfeld C, Imboden J, Wu Y, Del Puerto G, Nitta E, Shigenaga J, Schnell Heringer A, Ganz P, Graf J. Depletion of B-cells with rituximab improves endothelial function and reduces inflammation among individuals with rheumatoid arthritis. J Am Heart Assoc. 2014 Oct 21; 3(5):e001267. PMID: 25336464; PMCID: PMC4323827.
    11. Lee CH, Srikhum W, Burghardt AJ, Virayavanich W, Imboden J, Link TM, Li X. Correlation of structural abnormalities of the wrist and metacarpophalangeal joints evaluated by high-resolution peripheral quantitative computed tomography, 3 Tesla magnetic resonance imaging and conventional radiographs in rheumatoid arthritis. Int J Rheum Dis. 2015 Jul; 18(6):628-39. PMID: 25293500.
      View in: PubMed
    12. Carlson AQ, Tuot DS, Jen KY, Butcher B, Graf J, Sam R, Imboden J. Pauci-immune glomerulonephritis in individuals with disease associated with levamisole-adulterated cocaine: a series of 4 cases. Medicine (Baltimore). 2014 Oct; 93(17):290-7. PMID: 25398064; PMCID: PMC4602417.
    13. Teruel JR, Burghardt AJ, Rivoire J, Srikhum W, Noworolski SM, Link TM, Imboden J, Li X. Bone structure and perfusion quantification of bone marrow edema pattern in the wrist of patients with rheumatoid arthritis: a multimodality study. J Rheumatol. 2014 Sep; 41(9):1766-73. PMID: 25086074.
      View in: PubMed
    14. Barton JL, Trupin L, Tonner C, Imboden J, Katz P, Schillinger D, Yelin E. English language proficiency, health literacy, and trust in physician are associated with shared decision making in rheumatoid arthritis. J Rheumatol. 2014 Jul; 41(7):1290-7. PMID: 24931952; PMCID: PMC4286372.
    15. Coffey G, Betz A, Graf J, Stephens G, Hua Lin P, Imboden J, Sinha U. Methotrexate and a spleen tyrosine kinase inhibitor cooperate to inhibit responses to peripheral blood B cells in rheumatoid arthritis. Pharmacol Res Perspect. 2013 Dec; 1(2):e00016. PMID: 25505569; PMCID: PMC4186432.
    16. Burghardt AJ, Lee CH, Kuo D, Majumdar S, Imboden J, Link TM, Li X. Quantitative in vivo HR-pQCT imaging of 3D wrist and metacarpophalangeal joint space width in rheumatoid arthritis. Ann Biomed Eng. 2013 Dec; 41(12):2553-64. PMID: 23887879; PMCID: PMC3823828.
    17. Richman NC, Yazdany J, Graf J, Chernitskiy V, Imboden J. Extraarticular manifestations of rheumatoid arthritis in a multiethnic cohort of predominantly Hispanic and Asian patients. Medicine (Baltimore). 2013 Mar; 92(2):92-7. PMID: 23429352; PMCID: PMC4028062.
    18. Srikhum W, Virayavanich W, Burghardt AJ, Yu A, Link TM, Imboden J, Li X. Quantitative and semiquantitative bone erosion assessment on high-resolution peripheral quantitative computed tomography in rheumatoid arthritis. J Rheumatol. 2013 Apr; 40(4):408-16. PMID: 23418386.
      View in: PubMed
    19. Barton JL, Schmajuk G, Trupin L, Graf J, Imboden J, Yelin EH, Schillinger D. Poor knowledge of methotrexate associated with older age and limited English-language proficiency in a diverse rheumatoid arthritis cohort. Arthritis Res Ther. 2013; 15(5):R157. PMID: 24432366; PMCID: PMC3978686.
    20. Bajpai UD, Swainson LA, Mold JE, Graf JD, Imboden J, McCune JM. A functional variant in FCRL3 is associated with higher Fc receptor-like 3 expression on T cell subsets and rheumatoid arthritis disease activity. Arthritis Rheum. 2012 Aug; 64(8):2451-9. PMID: 22392608; PMCID: PMC3374037.
    21. Graf J, Lynch K, Yeh CL, Tarter L, Richman N, Nguyen T, Kral A, Dominy S, Imboden J. Purpura, cutaneous necrosis, and antineutrophil cytoplasmic antibodies associated with levamisole-adulterated cocaine. Arthritis Rheum. 2011 Dec; 63(12):3998-4001. PMID: 22127712.
      View in: PubMed
    22. Li X, Yu A, Virayavanich W, Noworolski SM, Link TM, Imboden J. Quantitative characterization of bone marrow edema pattern in rheumatoid arthritis using 3 Tesla MRI. J Magn Reson Imaging. 2012 Jan; 35(1):211-7. PMID: 21987483.
      View in: PubMed
    23. Barton JL, Trupin L, Schillinger D, Gansky SA, Tonner C, Margaretten M, Chernitskiy V, Graf J, Imboden J, Yelin E. Racial and ethnic disparities in disease activity and function among persons with rheumatoid arthritis from university-affiliated clinics. Arthritis Care Res (Hoboken). 2011 Sep; 63(9):1238-46. PMID: 21671414; PMCID: PMC3169768.
    24. Rooney T, Scherzer R, Shigenaga JK, Graf J, Imboden J, Grunfeld C. Levels of plasma fibrinogen are elevated in well-controlled rheumatoid arthritis. Rheumatology (Oxford). 2011 Aug; 50(8):1458-65. PMID: 21441551.
      View in: PubMed
    25. Margaretten M, Barton J, Julian L, Katz P, Trupin L, Tonner C, Graf J, Imboden J, Yelin E. Socioeconomic determinants of disability and depression in patients with rheumatoid arthritis. Arthritis Care Res (Hoboken). 2011 Feb; 63(2):240-6. PMID: 20824800; PMCID: PMC3716282.
    26. Gratton SB, Imboden J. A 23-year-old woman with fever, rash, and arthritis. Arthritis Care Res (Hoboken). 2010 Oct; 62(10):1507-12. PMID: 20506489.
      View in: PubMed
    27. Barton JL, Imboden J, Graf J, Glidden D, Yelin EH, Schillinger D. Patient-physician discordance in assessments of global disease severity in rheumatoid arthritis. Arthritis Care Res (Hoboken). 2010 Jun; 62(6):857-64. PMID: 20535797; PMCID: PMC2885009.
    28. Margaretten M, Yelin E, Imboden J, Graf J, Barton J, Katz P, Julian L. Predictors of depression in a multiethnic cohort of patients with rheumatoid arthritis. Arthritis Rheum. 2009 Nov 15; 61(11):1586-91. PMID: 19877099; PMCID: PMC2835470.
    29. Graf J, Scherzer R, Grunfeld C, Imboden J. Levels of C-reactive protein associated with high and very high cardiovascular risk are prevalent in patients with rheumatoid arthritis. PLoS One. 2009 Jul 16; 4(7):e6242. PMID: 19606218; PMCID: PMC2707000.
    30. Ku IA, Imboden J, Hsue PY, Ganz P. Rheumatoid arthritis: model of systemic inflammation driving atherosclerosis. Circ J. 2009 Jun; 73(6):977-85. PMID: 19430165.
      View in: PubMed
    31. Imboden J. The immunopathogenesis of rheumatoid arthritis. Annu Rev Pathol. 2009; 4:417-34. PMID: 18954286.
      View in: PubMed
    32. Hellmann DB, Imboden J. Update in rheumatology. Ann Intern Med. 2006 Dec 05; 145(11):834-8. PMID: 17146068.
      View in: PubMed
    33. Sadra A, Cinek T, Imboden J. Translocation of CD28 to lipid rafts and costimulation of IL-2. Proc Natl Acad Sci U S A. 2004 Aug 03; 101(31):11422-7. PMID: 15280538; PMCID: PMC509216.
    34. Andres PG, Howland KC, Nirula A, Kane LP, Barron L, Dresnek D, Sadra A, Imboden J, Weiss A, Abbas AK. Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation. Nat Immunol. 2004 Apr; 5(4):435-42. PMID: 15004555.
      View in: PubMed
    35. Chikuma S, Imboden J, Bluestone JA. Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4. J Exp Med. 2003 Jan 06; 197(1):129-35. PMID: 12515820; PMCID: PMC2193802.
    36. Imboden J, Shoback DM, Inokuchi S. Analysis of inositol phospholipid turnover during lymphocyte activation. Curr Protoc Immunol. 2001 May; Chapter 11:Unit 11.1. PMID: 18432702.
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    37. Sadra A, Cinek T, Imboden J. Multiple probing of an immunoblot membrane using a non-block technique: advantages in speed and sensitivity. Anal Biochem. 2000 Feb 15; 278(2):235-7. PMID: 10660470.
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    38. Cinek T, Sadra A, Imboden J. Cutting edge: tyrosine-independent transmission of inhibitory signals by CTLA-4. J Immunol. 2000 Jan 01; 164(1):5-8. PMID: 10604984.
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    39. Sadra A, Cinek T, Arellano JL, Shi J, Truitt KE, Imboden J. Identification of tyrosine phosphorylation sites in the CD28 cytoplasmic domain and their role in the costimulation of Jurkat T cells. J Immunol. 1999 Feb 15; 162(4):1966-73. PMID: 9973466.
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    40. Barz C, Nagel T, Truitt KE, Imboden J. Mutational analysis of CD28-mediated costimulation of Jun-N-terminal kinase and IL-2 production. J Immunol. 1998 Nov 15; 161(10):5366-72. PMID: 9820510.
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    41. Weber JR, Orstavik S, Torgersen KM, Danbolt NC, Berg SF, Ryan JC, Taskén K, Imboden J, Vaage JT. Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells. J Exp Med. 1998 Apr 06; 187(7):1157-61. PMID: 9529333; PMCID: PMC2212210.
    42. Daikh D, Wofsy D, Imboden J. The CD28-B7 costimulatory pathway and its role in autoimmune disease. J Leukoc Biol. 1997 Aug; 62(2):156-62. PMID: 9261329.
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    43. Shapiro VS, Truitt KE, Imboden J, Weiss A. CD28 mediates transcriptional upregulation of the interleukin-2 (IL-2) promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites. Mol Cell Biol. 1997 Jul; 17(7):4051-8. PMID: 9199340; PMCID: PMC232258.
    44. Shi J, Cinek T, Truitt KE, Imboden J. Wortmannin, a phosphatidylinositol 3-kinase inhibitor, blocks antigen-mediated, but not CD3 monoclonal antibody-induced, activation of murine CD4+ T cells. J Immunol. 1997 May 15; 158(10):4688-95. PMID: 9144481.
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    45. Imboden J. Turning off natural killers. Innate immunity. Curr Biol. 1996 Sep 01; 6(9):1070-2. PMID: 8805356.
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    46. Truitt KE, Nagel T, Suen LF, Imboden J. Structural requirements for CD28-mediated costimulation of IL-2 production in Jurkat T cells. J Immunol. 1996 Jun 15; 156(12):4539-41. PMID: 8648094.
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    47. Bell GM, Fargnoli J, Bolen JB, Kish L, Imboden J. The SH3 domain of p56lck binds to proline-rich sequences in the cytoplasmic domain of CD2. J Exp Med. 1996 Jan 01; 183(1):169-78. PMID: 8551220; PMCID: PMC2192399.
    48. Truitt KE, Shi J, Gibson S, Segal LG, Mills GB, Imboden J. CD28 delivers costimulatory signals independently of its association with phosphatidylinositol 3-kinase. J Immunol. 1995 Nov 15; 155(10):4702-10. PMID: 7594470.
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    49. Bell GM, Imboden J. CD2 and the regulation of T cell anergy. J Immunol. 1995 Sep 15; 155(6):2805-7. PMID: 7673695.
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    50. Imboden J, Koretsky GA. Intracellular signalling. Switching off signals. Curr Biol. 1995 Jul 01; 5(7):727-9. PMID: 7583115.
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    51. Sánchez-Margalet V, Goldfine ID, Truitt K, Imboden J, Sung CK. Role of p85 subunit of phosphatidylinositol-3-kinase as an adaptor molecule linking the insulin receptor to insulin receptor substrate 1. Mol Endocrinol. 1995 Apr; 9(4):435-42. PMID: 7659087.
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    52. Truitt KE, Hicks CM, Imboden J. Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells. J Exp Med. 1994 Mar 01; 179(3):1071-6. PMID: 7509360; PMCID: PMC2191424.
    53. Truitt KE, Mills GB, Turck CW, Imboden J. SH2-dependent association of phosphatidylinositol 3'-kinase 85-kDa regulatory subunit with the interleukin-2 receptor beta chain. J Biol Chem. 1994 Feb 25; 269(8):5937-43. PMID: 7509794.
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    54. Bell GM, Dethloff GM, Imboden J. CD45-negative mutants of a rat natural killer cell line fail to lyse tumor target cells. J Immunol. 1993 Oct 01; 151(7):3646-53. PMID: 8104222.
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    55. Bell GM, Bolen JB, Imboden J. Association of Src-like protein tyrosine kinases with the CD2 cell surface molecule in rat T lymphocytes and natural killer cells. Mol Cell Biol. 1992 Dec; 12(12):5548-54. PMID: 1280324; PMCID: PMC360493.
    56. Weber JR, Bell GM, Han MY, Pawson T, Imboden J. Association of the tyrosine kinase LCK with phospholipase C-gamma 1 after stimulation of the T cell antigen receptor. J Exp Med. 1992 Aug 01; 176(2):373-9. PMID: 1500851; PMCID: PMC2119313.
    57. Bell GM, Seaman WE, Niemi EC, Imboden J. The OX-44 molecule couples to signaling pathways and is associated with CD2 on rat T lymphocytes and a natural killer cell line. J Exp Med. 1992 Feb 01; 175(2):527-36. PMID: 1346273; PMCID: PMC2119111.
    58. Goldfien RD, Seaman WE, Hempel WM, Imboden J. Divergent regulation of phospholipase C-alpha and phospholipase C-gamma transcripts during activation of a human T cell line. J Immunol. 1991 Jun 01; 146(11):3703-8. PMID: 2033247.
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    59. Imboden J, Bell G, Seaman WE. Characterization of signal-transducing molecules on natural killer cells. Biochem Soc Trans. 1991 Apr; 19(2):265-8. PMID: 1679728.
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    60. Seaman WE, Niemi EC, Stark MR, Goldfien RD, Pollock AS, Imboden J. Molecular cloning of gp42, a cell-surface molecule that is selectively induced on rat natural killer cells by interleukin 2: glycolipid membrane anchoring and capacity for transmembrane signaling. J Exp Med. 1991 Jan 01; 173(1):251-60. PMID: 1845873; PMCID: PMC2118766.
    61. Inokuchi S, Imboden J. Antigen receptor-mediated regulation of sustained polyphosphoinositide turnover in a human T cell line. Evidence for a receptor-regulated pathway for production of phosphatidylinositol 4,5-bisphosphate. J Biol Chem. 1990 Apr 15; 265(11):5983-9. PMID: 2156835.
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    62. Imboden J, June CH, McCutcheon MA, Ledbetter JA. Stimulation of CD5 enhances signal transduction by the T cell antigen receptor. J Clin Invest. 1990 Jan; 85(1):130-4. PMID: 1688565; PMCID: PMC296396.
    63. Imboden J, Eriksson EC, McCutcheon M, Reynolds CW, Seaman WE. Identification and characterization of a cell-surface molecule that is selectively induced on rat lymphokine-activated killer cells. J Immunol. 1989 Nov 01; 143(9):3100-3. PMID: 2809220.
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    64. Imboden J, Weiss A. The T-cell antigen receptor regulates sustained increases in cytoplasmic free Ca2+ through extracellular Ca2+ influx and ongoing intracellular Ca2+ mobilization. Biochem J. 1987 Nov 01; 247(3):695-700. PMID: 3426556; PMCID: PMC1148468.
    65. Manger B, Weiss A, Imboden J, Laing T, Stobo JD. The role of protein kinase C in transmembrane signaling by the T cell antigen receptor complex. Effects of stimulation with soluble or immobilized CD3 antibodies. J Immunol. 1987 Oct 15; 139(8):2755-60. PMID: 3116093.
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    66. Weiss A, Imboden J. Cell surface molecules and early events involved in human T lymphocyte activation. Adv Immunol. 1987; 41:1-38. PMID: 2961214.
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    67. Imboden J, Weiss A, Stobo JD. Transmembrane signalling by the T3-antigen receptor complex. Immunol Today. 1985 Nov; 6(11):328-31. PMID: 25291003.
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    68. Kramer PH, Imboden J, Waldman FM, Turley K, Ports TA. Severe aortic insufficiency in juvenile chronic arthritis. Am J Med. 1983 Jun; 74(6):1088-91. PMID: 6859059.
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