Judith Ashouri Sinha, MD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Address513 Parnassus Ave, MSB, #1032A
San Francisco CA 94117
Phone415-476-7160
Pronounsshe/her/hers
ORCID ORCID Icon0000-0001-8405-7503 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, San Francisco , San Francisco, CAMD06/2008
    Stanford University Hospital & Clinics, Palo Alto, CAResidency06/2011Internal Medicine
    University of California, San Francisco , San Francisco, CAFellowship 06/2014Rheumatology
    University of California, San Francisco, CA01/2022Diversity, Equity, and Inclusion Champion Training
    Collapse Awards and Honors
    Rheumatology Research Foundation2012  - 2015Scientist Development Award
    UCSF Division of Rheumatology2016  - 2019Bechtel Junior Faculty Award
    Rheumatology Research Foundation 2017  - 2018K Bridge Award
    Arthritis National Research Foundation2018  - 2020Arthritis National Research Foundation Scholar

    Collapse Overview 
    Collapse Overview
    Rheumatoid arthritis (RA) afflicts millions globally, causing significant joint deformity, pain, and functional disability. RA is without cure and its cause is unknown, but CD4 T cells—immune cells widely accepted to play a key role in RA pathogenesis—from patients with RA become activated by proteins through their T cell receptor (called “antigen-specific T cells”) and cause arthritis. Dr. Ashouri’s research uses a unique tool to identify and characterize these antigen-activated T cells in both a mouse model of RA and human RA. Elucidating the contribution of these pathogenic CD4 T cells to arthritis development in RA holds promise for the discovery of improved therapeutic targets.

    Collapse Research 
    Collapse Research Activities and Funding
    Signaling and repertoire differences in arthritogenic T cells
    NIH K08AR072144Aug 1, 2018 - Jul 31, 2023
    Role: Primary Investigator
    Decoding rheumatoid arthritis using a unique tool to identify arthritogenic T cells
    Arthritis National Research Foundation (ANRF) A131454Jun 1, 2018 - May 31, 2020
    Role: Primary Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Collaboration Interests

    Collapse Featured Content 
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Repeated immunization with ATRA-containing liposomal adjuvant transdifferentiates Th17 cells to a Tr1-like phenotype. J Autoimmun. 2024 Apr; 144:103174. Wørzner K, Zimmermann J, Buhl R, Desoi A, Christensen D, Dietrich J, Nguyen NDNT, Lindenstrøm T, Woodworth JS, Alhakeem RS, Yu S, Ødum N, Mortensen R, Ashouri JF, Pedersen GK. PMID: 38377868.
      View in: PubMed   Mentions:    Fields:    
    2. Hepatic Ly6CLo Non-Classical Monocytes Have Increased Nr4a1 (Nur77) in Murine Biliary Atresia. J Clin Med. 2022 Sep 08; 11(18). Mohamedaly S, Levy CS, Korsholm C, Alkhani A, Rosenberg K, Ashouri JF, Nijagal A. PMID: 36142937; PMCID: PMC9504567.
      View in: PubMed   Mentions:
    3. ZAP70, too little, too much can lead to autoimmunity. Immunol Rev. 2022 05; 307(1):145-160. Ashouri JF, Lo WL, Nguyen TTT, Shen L, Weiss A. PMID: 34923645; PMCID: PMC8986586.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    4. Cross-Tissue Transcriptomic Analysis Leveraging Machine Learning Approaches Identifies New Biomarkers for Rheumatoid Arthritis. Front Immunol. 2021; 12:638066. Rychkov D, Neely J, Oskotsky T, Yu S, Perlmutter N, Nititham J, Carvidi A, Krueger M, Gross A, Criswell LA, Ashouri JF, Sirota M. PMID: 34177888; PMCID: PMC8223752.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    5. The Therapeutic Landscape of Rheumatoid Arthritis: Current State and Future Directions. Front Pharmacol. 2021; 12:680043. Shams S, Martinez JM, Dawson JRD, Flores J, Gabriel M, Garcia G, Guevara A, Murray K, Pacifici N, Vargas MV, Voelker T, Hell JW, Ashouri JF. PMID: 34122106; PMCID: PMC8194305.
      View in: PubMed   Mentions: 32  
    6. Therapeutic Implications of Diet in Inflammatory Bowel Disease and Related Immune-Mediated Inflammatory Diseases. Nutrients. 2021 Mar 10; 13(3). Jiang Y, Jarr K, Layton C, Gardner CD, Ashouri JF, Abreu MT, Sinha SR. PMID: 33801883; PMCID: PMC8001318.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    7. Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature. Cell Rep Med. 2020 11 17; 1(8):100132. Dhariwala MO, Karthikeyan D, Vasquez KS, Farhat S, Weckel A, Taravati K, Leitner EG, Clancy S, Pauli M, Piper ML, Cohen JN, Ashouri JF, Lowe MM, Rosenblum MD, Scharschmidt TC. PMID: 33294857; PMCID: PMC7691438.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    8. Efficacy of Dietary Supplements in Inflammatory Bowel Disease and Related Autoimmune Diseases. Nutrients. 2020 Jul 20; 12(7). Jadhav P, Jiang Y, Jarr K, Layton C, Ashouri JF, Sinha SR. PMID: 32698454; PMCID: PMC7400845.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    9. Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis. Proc Natl Acad Sci U S A. 2019 09 10; 116(37):18517-18527. Ashouri JF, Hsu LY, Yu S, Rychkov D, Chen Y, Cheng DA, Sirota M, Hansen E, Lattanza L, Zikherman J, Weiss A. PMID: 31455730; PMCID: PMC6744919.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    10. Endogenous Nur77 Is a Specific Indicator of Antigen Receptor Signaling in Human T and B Cells. J Immunol. 2017 01 15; 198(2):657-668. Ashouri JF, Weiss A. PMID: 27940659; PMCID: PMC5224971.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    11. A sharp T-cell antigen receptor signaling threshold for T-cell proliferation. Proc Natl Acad Sci U S A. 2014 Sep 02; 111(35):E3679-88. Au-Yeung BB, Zikherman J, Mueller JL, Ashouri JF, Matloubian M, Cheng DA, Chen Y, Shokat KM, Weiss A. PMID: 25136127; PMCID: PMC4156735.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    12. The "Prediction of Alcohol Withdrawal Severity Scale" (PAWSS): systematic literature review and pilot study of a new scale for the prediction of complicated alcohol withdrawal syndrome. Alcohol. 2014 Jun; 48(4):375-90. Maldonado JR, Sher Y, Ashouri JF, Hills-Evans K, Swendsen H, Lolak S, Miller AC. PMID: 24657098.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    13. A young woman with systemic lupus erythematosus and extensive mesenteric vasculitis involving small and medium vessels. Arthritis Care Res (Hoboken). 2012 Dec; 64(12):1928-33. Ashouri JF, Davis JL, Farkas A, Durack JC, Ramachandran R, Dall'Era M. PMID: 22933330.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    14. Rheumatic manifestations of cancer. Rheum Dis Clin North Am. 2011 Nov; 37(4):489-505. Ashouri JF, Daikh DI. PMID: 22075194.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. Transcriptional regulation of EGR-1 by the interleukin-1-JNK-MKK7-c-Jun pathway. J Biol Chem. 2008 May 02; 283(18):12120-8. Hoffmann E, Ashouri J, Wolter S, Doerrie A, Dittrich-Breiholz O, Schneider H, Wagner EF, Troppmair J, Mackman N, Kracht M. PMID: 18281687.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    16. Androgens are protective in experimental autoimmune encephalomyelitis: implications for multiple sclerosis. J Neuroimmunol. 2004 Jan; 146(1-2):144-52. Palaszynski KM, Loo KK, Ashouri JF, Liu HB, Voskuhl RR. PMID: 14698857.
      View in: PubMed   Mentions: 65     Fields:    Translation:Animals
    17. Estrogen receptor alpha mediates estrogen's immune protection in autoimmune disease. J Immunol. 2003 Dec 15; 171(12):6936-40. Liu HB, Loo KK, Palaszynski K, Ashouri J, Lubahn DB, Voskuhl RR. PMID: 14662901.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells