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Matthew Zinter, MD

Title(s)Assistant Professor, Pediatrics
SchoolSchool of Medicine
Phone415-476-3685
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    Collapse Biography 
    Collapse Education and Training
    Washington University, St. LouisBA6/2007Biology
    Washington University, St. LouisMD6/2011Medicine
    UCSF, San Francisco6/2014Pediatrics
    UCSF, San Francisco6/2018Pediatric Critical Care Medicine
    Collapse Awards and Honors
    NIH NHLBI2017Pediatric Research Loan Repayment Award
    UCSF2018Melvin M. Grumbach Award for Excellence in Research by a UCSF Pediatric Fellow

    Collapse Overview 
    Collapse Overview
    I study the pathobiology of critical illness, including organ dysfunction and infection, in children with cancer, immunodeficiencies, and those who have undergone hematopoietic stem cell transplantation.

    Collapse Research 
    Collapse Research Activities and Funding
    Pathobiologic Transcriptional Signatures of Pulmonary Complications in Pediatric Hematopoietic Cellular Transplantation
    NIH NHLBI K23HL146936Feb 1, 2020 - Jan 31, 2025
    Role: Principal Investigator
    Metatranscriptomic Evaluation of Lung Health in Pediatric Hematopoietic Cell Transplant Candidates
    American Thoracic Society Foundation GrantJan 15, 2020 - Jan 14, 2021
    Role: Principal Investigator
    Transcriptional and Molecular Signatures of Lung Injury in Pediatric Hematopoietic Cellular Transplantation
    National Marrow Donor Program Amy Strelzer Manasevit GrantJun 1, 2017 - May 31, 2020
    Role: Principal Investigator
    Pathogen Identification in Pediatric Hematopoietic Stem Cell Transplant Patients with Suspected Lower Respiratory Tract Infection
    Pediatric Blood and Marrow Transplant Consortium Foundation GrantJun 1, 2016 - Dec 31, 2019
    Role: Principal Investigator
    Pathogen Identification in Pediatric Hematopoietic Stem Cell Transplant Patients with Suspected Lower Respiratory Tract Infection
    NIH NICHD K12HD000850Jun 1, 2016 - May 31, 2018
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Zinter MS, Cheng GS. Acute hypoxaemic respiratory failure in immunocompromised patients: abandon bronchoscopy or make it better? Eur Respir J. 2019 Dec; 54(6). PMID: 31831674.
      View in: PubMed
    2. Lau-Braunhut SA, Stone H, Collins G, Berentsen S, Braun BS, Zinter MS. Paroxysmal cold hemoglobinuria successfully treated with complement inhibition. Blood Adv. 2019 Nov 26; 3(22):3575-3578. PMID: 31738828.
      View in: PubMed
    3. Crawford E, Kamm J, Miller S, Li LM, Caldera S, Lyden A, Yokoe D, Nichols A, Tran NK, Barnard SE, Conner PM, Nambiar A, Zinter MS, Moayeri M, Serpa PH, Prince BC, Quan J, Sit R, Tan M, Phelps M, DeRisi JL, Tato CM, Langelier C. Investigating Transfusion-Related Sepsis using Culture-Independent Metagenomic Sequencing. Clin Infect Dis. 2019 Sep 29. PMID: 31563940.
      View in: PubMed
    4. Zinter MS, Logan BR, Fretham C, Sapru A, Abraham A, Aljurf MD, Arnold SD, Artz A, Auletta JJ, Chhabra S, Copelan E, Duncan C, Gale RP, Guinan E, Hematti P, Keating AK, Marks DI, Olsson R, Savani BN, Ustun C, Williams KM, Pasquini MC, Dvorak CC. Comprehensive Prognostication in Critically Ill Pediatric Hematopoietic Cell Transplant Patients: Results from Merging the Center for International Blood and Marrow Transplant Research (CIBMTR) and Virtual Pediatric Systems (VPS) Registries. Biol Blood Marrow Transplant. 2019 Sep 26. PMID: 31563573.
      View in: PubMed
    5. Hanudel MR, Zinter MS, Chen L, Gala K, Lim M, Guglielmo M, Deshmukh T, Vangala S, Matthay M, Sapru A. Plasma total fibroblast growth factor 23 levels are associated with acute kidney injury and mortality in children with acute respiratory distress syndrome. PLoS One. 2019; 14(9):e0222065. PMID: 31487315.
      View in: PubMed
    6. Zinter MS, Hermiston ML. Calming the storm in HLH. Blood. 2019 Jul 11; 134(2):103-104. PMID: 31296541.
      View in: PubMed
    7. Mueller DM, Markovitz BP, Zinter MS, Takimoto SW, Khemani RG. Risk Factors for Mortality and Pre-ICU Fluid Balance Among Critically Ill Hematopoietic Stem Cell Transplant Patients. J Intensive Care Med. 2019 Jun 11; 885066619855618. PMID: 31185788.
      View in: PubMed
    8. Zinter MS, Dvorak CC, Mayday MY, Iwanaga K, Ly NP, McGarry ME, Church GD, Faricy LE, Rowan CM, Hume JR, Steiner ME, Crawford ED, Langelier C, Kalantar K, Chow ED, Miller S, Shimano K, Melton A, Yanik GA, Sapru A, DeRisi JL. Pulmonary Metagenomic Sequencing Suggests Missed Infections in Immunocompromised Children. Clin Infect Dis. 2019 May 17; 68(11):1847-1855. PMID: 30239621.
      View in: PubMed
    9. Zinter MS, Mayday MY, Ryckman KK, Jelliffe-Pawlowski LL, DeRisi JL. Towards precision quantification of contamination in metagenomic sequencing experiments. Microbiome. 2019 04 16; 7(1):62. PMID: 30992055.
      View in: PubMed
    10. Zinter MS, Spicer AC, Liu KD, Orwoll BE, Alkhouli MF, Brakeman PR, Calfee CS, Matthay MA, Sapru A. Positive Cumulative Fluid Balance Is Associated With Mortality in Pediatric Acute Respiratory Distress Syndrome in the Setting of Acute Kidney Injury. Pediatr Crit Care Med. 2019 04; 20(4):323-331. PMID: 30672838.
      View in: PubMed
    11. Zinter MS, Delucchi KL, Kong MY, Orwoll BE, Spicer AS, Lim MJ, Alkhouli MF, Ratiu AE, McKenzie AV, McQuillen PS, Dvorak CC, Calfee CS, Matthay MA, Sapru A. Early Plasma Matrix Metalloproteinase Profiles. A Novel Pathway in Pediatric Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2019 01 15; 199(2):181-189. PMID: 30114376.
      View in: PubMed
    12. Mayday MY, Khan LM, Chow ED, Zinter MS, DeRisi JL. Miniaturization and optimization of 384-well compatible RNA sequencing library preparation. PLoS One. 2019; 14(1):e0206194. PMID: 30629604.
      View in: PubMed
    13. Langelier C, Kalantar KL, Moazed F, Wilson MR, Crawford ED, Deiss T, Belzer A, Bolourchi S, Caldera S, Fung M, Jauregui A, Malcolm K, Lyden A, Khan L, Vessel K, Quan J, Zinter M, Chiu CY, Chow ED, Wilson J, Miller S, Matthay MA, Pollard KS, Christenson S, Calfee CS, DeRisi JL. Integrating host response and unbiased microbe detection for lower respiratory tract infection diagnosis in critically ill adults. Proc Natl Acad Sci U S A. 2018 12 26; 115(52):E12353-E12362. PMID: 30482864.
      View in: PubMed
    14. Dean T, Kaushik N, Williams S, Zinter M, Kim P. Cardiac arrest and pulmonary hypertension in scurvy: a case report. Pulm Circ. 2019 Jan-Mar; 9(1):2045894018812052. PMID: 30351242.
      View in: PubMed
    15. Balkin EM, Zinter MS, Rajagopal SK, Keller RL, Fineman JR, Steurer MA. Intensive Care Mortality Prognostic Model for Pediatric Pulmonary Hypertension. Pediatr Crit Care Med. 2018 08; 19(8):733-740. PMID: 29923941.
      View in: PubMed
    16. Rowan CM, Gertz SJ, Zinter MS, Moffet J, Bajwa RPS, Barnum JL, Kong M. A multicenter investigation of respiratory syncytial viral infection in children with hematopoietic cell transplantation. Transpl Infect Dis. 2018 Jun; 20(3):e12882. PMID: 29573141.
      View in: PubMed
    17. Langelier C, Zinter MS, Kalantar K, Yanik GA, Christenson S, O'Donovan B, White C, Wilson M, Sapru A, Dvorak CC, Miller S, Chiu CY, DeRisi JL. Metagenomic Sequencing Detects Respiratory Pathogens in Hematopoietic Cellular Transplant Patients. Am J Respir Crit Care Med. 2018 02 15; 197(4):524-528. PMID: 28686513.
      View in: PubMed
    18. Balkin EM, Steurer MA, Delagnes EA, Zinter MS, Rajagopal S, Keller RL, Fineman JR. Multicenter mortality and morbidity associated with pulmonary hypertension in the pediatric intensive care unit. Pulm Circ. 2018 Jan-Mar; 8(1):2045893217745785. PMID: 29251545.
      View in: PubMed
    19. Zinter MS, Holubkov R, Steurer MA, Dvorak CC, Duncan CN, Sapru A, Tamburro RF, McQuillen PS, Pollack MM. Pediatric Hematopoietic Cell Transplant Patients Who Survive Critical Illness Frequently Have Significant but Recoverable Decline in Functional Status. Biol Blood Marrow Transplant. 2018 02; 24(2):330-336. PMID: 29128553.
      View in: PubMed
    20. Zinter MS, Melton A, Sabnis AJ, Dvorak CC, Elicker BM, Nawaytou HM, Kameny RJ, Fineman JR. Pulmonary veno-occlusive disease in a pediatric hematopoietic stem cell transplant patient: a cautionary tale. Leuk Lymphoma. 2018 06; 59(6):1494-1497. PMID: 28958195.
      View in: PubMed
    21. Zinter MS, Barrows BD, Ursell PC, Kowalek K, Kalantar K, Cambronero N, DeRisi JL, Oishi P, Dvorak CC. Extracorporeal life support survival in a pediatric hematopoietic cellular transplant recipient with presumed GvHD-related fulminant myocarditis. Bone Marrow Transplant. 2017 09; 52(9):1330-1333. PMID: 28581474.
      View in: PubMed
    22. Delgado-Martin C, Meyer LK, Huang BJ, Shimano KA, Zinter MS, Nguyen JV, Smith GA, Taunton J, Winter SS, Roderick JR, Kelliher MA, Horton TM, Wood BL, Teachey DT, Hermiston ML. JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias. Leukemia. 2017 12; 31(12):2568-2576. PMID: 28484265.
      View in: PubMed
    23. Zinter MS, Orwoll BE, Spicer AC, Alkhouli MF, Calfee CS, Matthay MA, Sapru A. Incorporating Inflammation into Mortality Risk in Pediatric Acute Respiratory Distress Syndrome. Crit Care Med. 2017 May; 45(5):858-866. PMID: 28248715.
      View in: PubMed
    24. Spicer AC, Calfee CS, Zinter MS, Khemani RG, Lo VP, Alkhouli MF, Orwoll BE, Graciano AL, Boriosi JP, Howard JP, Flori HR, Matthay MA, Sapru A. A Simple and Robust Bedside Model for Mortality Risk in Pediatric Patients With Acute Respiratory Distress Syndrome. Pediatr Crit Care Med. 2016 10; 17(10):907-916. PMID: 27487912.
      View in: PubMed
    25. Levy ER, Musick L, Zinter MS, Lang T, Cowan MJ, Weintrub PS, Dvorak CC. Safe and Effective Prophylaxis with Bimonthly Intravenous Pentamidine in the Pediatric Hematopoietic Stem Cell Transplant Population. Pediatr Infect Dis J. 2016 Feb; 35(2):135-41. PMID: 26418240.
      View in: PubMed
    26. Orwoll BE, Spicer AC, Zinter MS, Alkhouli MF, Khemani RG, Flori HR, Neuhaus JM, Calfee CS, Matthay MA, Sapru A. Elevated soluble thrombomodulin is associated with organ failure and mortality in children with acute respiratory distress syndrome (ARDS): a prospective observational cohort study. Crit Care. 2015 Dec 14; 19:435. PMID: 26652251.
      View in: PubMed
    27. Zinter MS, Spicer A, Orwoll BO, Alkhouli M, Dvorak CC, Calfee CS, Matthay MA, Sapru A. Plasma angiopoietin-2 outperforms other markers of endothelial injury in prognosticating pediatric ARDS mortality. Am J Physiol Lung Cell Mol Physiol. 2016 Feb 01; 310(3):L224-31. PMID: 26660787.
      View in: PubMed
    28. Zinter MS, Dvorak CC, Spicer A, Cowan MJ, Sapru A. New Insights Into Multicenter PICU Mortality Among Pediatric Hematopoietic Stem Cell Transplant Patients. Crit Care Med. 2015 Sep; 43(9):1986-94. PMID: 26035280.
      View in: PubMed
    29. Zinter MS, Levy ER, Gertz SJ. A review of pathogens causing lower respiratory tract infection in the pediatric hematopoietic stem cell transplant recipient. J Pediatr Intensive Care. 2014 Sep; 3(3):115-132. PMID: 31214460.
      View in: PubMed
    30. Zinter MS, DuBois SG, Spicer A, Matthay K, Sapru A. Pediatric cancer type predicts infection rate, need for critical care intervention, and mortality in the pediatric intensive care unit. Intensive Care Med. 2014 Oct; 40(10):1536-44. PMID: 25023526.
      View in: PubMed
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