Henry Chambers, III, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address1001 Potrero Ave
San Francisco CA 94110
Phone628-206-5437
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    Other Positions
    Title(s)Chief, Division of Infectious Diseases, SFGH

    Title(s)Director, Clinical Research Services, CTSI


    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency School of Medicine
    Vanderbilt UniversityM.D.School of Medicine
    Centre College Kentucky B.A.

    Collapse Overview 
    Collapse Overview
    Dr. Chambers clinical and research interests are antimicrobial drug resistance, staphylococcal infections, experimental therapeutics, and epidemiology and pathogenesis of disease caused by Staphylococcus aureus. He is editor for the Sanford Guide to Antimicrobial Therapy and he has over 200 original publications and textbook chapters in the areas of drug resistance, endocarditis, bacterial infections, and staphylococcal diseases.

    Dr. Chambers received his BA from Centre College in Kentucky and is a graduate of the Vanderbilt University School of Medicine. He trained in Internal Medicine and Infectious Diseases at the University of California San Francisco. Dr. Chambers has been a member of the medical faculty of the UCSF since 1983 where he currently is Professor of Medicine, Medical Director of Clinical Research Services for CTSI. He is an editor for Antimicrobial Agents and Chemotherapy, a reviewer for numerous medical publications, a peer reviewer for NIH study sections.

    Collapse Research 
    Collapse Research Activities and Funding
    Antibacterial Resistance Leadership Group (ARLG)
    NIH UM1AI104681Jun 1, 2013 - Nov 30, 2026
    Role: Co-Principal Investigator
    Novel Mechanisms of Beta-lactam Resistance in Staph Aureus
    NIH R01AI100291Aug 1, 2012 - Dec 31, 2022
    Role: Principal Investigator
    Novel Mechanisms of Beta-lactam Resistance in Staph Aureus
    NIH R56AI100291Aug 1, 2012 - Dec 31, 2017
    Role: Principal Investigator
    Genetic Basis of Virulence of Community MRSA Clone USA300
    NIH R01AI070289Apr 1, 2008 - Mar 31, 2012
    Role: Principal Investigator
    Gordon Research Conference on Staphylococcal Diseases
    NIH R13AI050556Jul 1, 2001 - Jun 30, 2002
    Role: Principal Investigator
    Biology of Infectious Diseases Training Program
    NIH T32AI007641Aug 1, 2000 - Aug 31, 2022
    Role: Principal Investigator
    PENICILLIN INTERACTIVE PROTEINS OF STAPHYLOCOCCUS AUREUS
    NIH R01AI046610Feb 1, 2000 - Jan 31, 2005
    Role: Principal Investigator
    GORDON CONFERENCE ON STAPHYLOCOCCAL DISEASES
    NIH R13AI043943May 1, 1999 - Apr 30, 2000
    Role: Principal Investigator
    VANCOMYCIN-RESISTANT STAPHYLOCOCCUS AUREUS
    NIH R03AI043959Apr 1, 1999 - Mar 31, 2002
    Role: Principal Investigator
    PENICILLIN BINDING PROTEINS OF STAPHYLOCOCCUS AUREUS
    NIH R21AI032496Sep 30, 1996 - Sep 29, 1999
    Role: Principal Investigator
    DEVELOPMENT OF DRUGS FOR TREATING TUBERCULOSIS
    NIH R01AI033702Sep 30, 1992 - Aug 31, 1997
    Role: Principal Investigator
    METHICILLIN RESISTANCE OF STAPHYLOCOCCUS AUREUS
    NIH R29AI027406Dec 1, 1988 - Nov 30, 1993
    Role: Principal Investigator
    General Clinical Research Center
    NIH M01RR000083Oct 1, 1974 - Nov 30, 2007
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Global Health

    Collapse Featured Content 
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Comparative one-year outcomes of invasive Staphylococcus aureus infections among persons with and without drug use: an observational cohort study. Clin Infect Dis. 2021 Apr 27. Appa A, Adamo M, Le S, Davis J, Winston L, Doernberg SB, Chambers H, Martin M, Hills NK, Coffin PO, Jain V. PMID: 33904900.
      View in: PubMed   Mentions:    Fields:    
    2. Impact of Bicarbonate on PBP2a Production, Maturation, and Functionality in Methicillin-Resistant Staphylococcus aureus (MRSA). Antimicrob Agents Chemother. 2021 Mar 01. Ersoy SC, Chambers HF, Proctor RA, Rosato AE, Mishra NN, Xiong YQ, Bayer AS. PMID: 33649115.
      View in: PubMed   Mentions: 1     Fields:    
    3. Skin and Soft Tissue Infections. Infect Dis Clin North Am. 2021 Mar; 35(1):xiii-xiv. Chambers HF. PMID: 33494875.
      View in: PubMed   Mentions:    Fields:    
    4. Importance of non-pharmaceutical interventions in lowering the viral inoculum to reduce susceptibility to infection by SARS-CoV-2 and potentially disease severity. Lancet Infect Dis. 2021 Feb 22. Spinelli MA, Glidden DV, Gennatas ED, Bielecki M, Beyrer C, Rutherford G, Chambers H, Goosby E, Gandhi M. PMID: 33631099.
      View in: PubMed   Mentions: 2     Fields:    
    5. Antibacterial Resistance Leadership Group 2.0 - Back to Business. Clin Infect Dis. 2021 Feb 15. Chambers HF, Evans SR, Patel R, Cross HR, Harris AD, Doi Y, Boucher HW, van Duin D, Tsalik EL, Holland TL, Pettigrew MM, Tamma PD, Hodges KR, Souli M, Fowler VG. PMID: 33588438.
      View in: PubMed   Mentions:    Fields:    
    6. Skin and Soft Tissue Infections in Persons Who Inject Drugs. Infect Dis Clin North Am. 2021 Mar; 35(1):169-181. Chambers HF. PMID: 33303334.
      View in: PubMed   Mentions:    Fields:    
    7. Rifabutin to the Rescue? J Infect Dis. 2020 10 01; 222(9):1422-1424. Chambers HF. PMID: 32914842.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    8. Native-Valve Infective Endocarditis. N Engl J Med. 2020 08 06; 383(6):567-576. Chambers HF, Bayer AS. PMID: 32757525.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    9. Differential Trends in Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Infections in Four Health Care Facilities in a Single Metropolitan Area: A Retrospective Analysis. Microb Drug Resist. 2021 Feb; 27(2):154-161. Raphael E, Chambers HF. PMID: 32589493.
      View in: PubMed   Mentions:    Fields:    
    10. Structural analysis of avibactam-mediated activation of the bla and mec divergons in methicillin-resistant Staphylococcus aureus. J Biol Chem. 2020 08 07; 295(32):10870-10884. Alexander JAN, Radaeva M, King DT, Chambers HF, Cherkasov A, Chatterjee SS, Strynadka NCJ. PMID: 32518158.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    11. Scope and Predictive Genetic/Phenotypic Signatures of Bicarbonate (NaHCO3) Responsiveness and ß-Lactam Sensitization in Methicillin-Resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2020 04 21; 64(5). Ersoy SC, Otmishi M, Milan VT, Li L, Pak Y, Mediavilla J, Chen L, Kreiswirth B, Chambers HF, Proctor RA, Xiong YQ, Fowler VG, Bayer AS. PMID: 32041719.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    12. The Emperor's New Clothes: PRospective Observational Evaluation of the Association Between Initial VancomycIn Exposure and Failure Rates Among ADult HospitalizEd Patients With Methicillin-resistant Staphylococcus aureus Bloodstream Infections (PROVIDE). Clin Infect Dis. 2020 04 10; 70(8):1536-1545. Lodise TP, Rosenkranz SL, Finnemeyer M, Evans S, Sims M, Zervos MJ, Creech CB, Patel PC, Keefer M, Riska P, Silveira FP, Scheetz M, Wunderink RG, Rodriguez M, Schrank J, Bleasdale SC, Schultz S, Barron M, Stapleton A, Wray D, Chambers H, Fowler VG, Holland TL. PMID: 31157370.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    13. Analytical Evaluation of the Abbott RealTime CT/NG Assay for Detection of Chlamydia trachomatis and Neisseria gonorrhoeae in Rectal and Pharyngeal Swabs. J Mol Diagn. 2020 06; 22(6):811-816. Adamson PC, Pandori MW, Doernberg SB, Komarow L, Sund Z, Tran TTT, Jensen D, Tsalik EL, Deal CD, Chambers HF, Fowler VG, Evans SR, Patel R, Klausner JD, Antibacterial Resistance Leadership Group . PMID: 32247863.
      View in: PubMed   Mentions:    Fields:    
    14. Molecular and clinical epidemiology of carbapenem-resistant Enterobacterales in the USA (CRACKLE-2): a prospective cohort study. Lancet Infect Dis. 2020 06; 20(6):731-741. van Duin D, Arias CA, Komarow L, Chen L, Hanson BM, Weston G, Cober E, Garner OB, Jacob JT, Satlin MJ, Fries BC, Garcia-Diaz J, Doi Y, Dhar S, Kaye KS, Earley M, Hujer AM, Hujer KM, Domitrovic TN, Shropshire WC, Dinh A, Manca C, Luterbach CL, Wang M, Paterson DL, Banerjee R, Patel R, Evans S, Hill C, Arias R, Chambers HF, Fowler VG, Kreiswirth BN, Bonomo RA, Multi-Drug Resistant Organism Network Investigators . PMID: 32151332.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    15. Ability of Bicarbonate Supplementation To Sensitize Selected Methicillin-Resistant Staphylococcus aureus Strains to ß-Lactam Antibiotics in an Ex Vivo Simulated Endocardial Vegetation Model. Antimicrob Agents Chemother. 2020 02 21; 64(3). Rose WE, Bienvenida AM, Xiong YQ, Chambers HF, Bayer AS, Ersoy SC. PMID: 31844004.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    16. Is Daptomycin plus Ceftaroline Associated with Better Clinical Outcomes than Standard of Care Monotherapy for Staphylococcus aureus Bacteremia? Antimicrob Agents Chemother. 2019 11; 63(11). Kalil AC, Holubar M, Deresinski S, Chambers HF. PMID: 31640977.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    17. Bicarbonate Resensitization of Methicillin-Resistant Staphylococcus aureus to ß-Lactam Antibiotics. Antimicrob Agents Chemother. 2019 07; 63(7). Ersoy SC, Abdelhady W, Li L, Chambers HF, Xiong YQ, Bayer AS. PMID: 31010857.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    18. Good Studies Evaluate the Disease While Great Studies Evaluate the Patient: Development and Application of a Desirability of Outcome Ranking Endpoint for Staphylococcus aureus Bloodstream Infection. Clin Infect Dis. 2019 05 02; 68(10):1691-1698. Doernberg SB, Tran TTT, Tong SYC, Paul M, Yahav D, Davis JS, Leibovici L, Boucher HW, Corey GR, Cosgrove SE, Chambers HF, Fowler VG, Evans SR, Holland TL, Antibacterial Resistance Leadership Group . PMID: 30321315.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    19. A Prognostic Model of Persistent Bacteremia and Mortality in Complicated Staphylococcus aureus Bloodstream Infection. Clin Infect Dis. 2019 04 24; 68(9):1502-1511. Guimaraes AO, Cao Y, Hong K, Mayba O, Peck MC, Gutierrez J, Ruffin F, Carrasco-Triguero M, Dinoso JB, Clemenzi-Allen A, Koss CA, Maskarinec SA, Chambers HF, Fowler VG, Baruch A, Rosenberger CM. PMID: 30165412.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    20. Omadacycline - The Newest Tetracycline. N Engl J Med. 2019 02 07; 380(6):588-589. Chambers HF. PMID: 30726683.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    21. Structural and kinetic analyses of penicillin-binding protein 4 (PBP4)-mediated antibiotic resistance in Staphylococcus aureus. J Biol Chem. 2018 12 21; 293(51):19854-19865. Alexander JAN, Chatterjee SS, Hamilton SM, Eltis LD, Chambers HF, Strynadka NCJ. PMID: 30366985.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    22. Essential Resources and Strategies for Antibiotic Stewardship Programs in the Acute Care Setting. Clin Infect Dis. 2018 09 28; 67(8):1168-1174. Doernberg SB, Abbo LM, Burdette SD, Fishman NO, Goodman EL, Kravitz GR, Leggett JE, Moehring RW, Newland JG, Robinson PA, Spivak ES, Tamma PD, Chambers HF. PMID: 29590355.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    23. PBP4: A New Perspective on Staphylococcus aureus ß-Lactam Resistance. Microorganisms. 2018 06 22; 6(3). da Costa TM, de Oliveira CR, Chambers HF, Chatterjee SS. PMID: 29932109.
      View in: PubMed   Mentions:
    24. PBP4 activity and its overexpression are necessary for PBP4-mediated high-level ß-lactam resistance. J Antimicrob Chemother. 2018 05 01; 73(5):1177-1180. Basuino L, Jousselin A, Alexander JAN, Strynadka NCJ, Pinho MG, Chambers HF, Chatterjee SS. PMID: 29360990.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    25. Sulfamethoxazole-Trimethoprim (Cotrimoxazole) for Skin and Soft Tissue Infections Including Impetigo, Cellulitis, and Abscess. Open Forum Infect Dis. 2017; 4(4):ofx232. Bowen AC, Carapetis JR, Currie BJ, Fowler V, Chambers HF, Tong SYC. PMID: 29255730.
      View in: PubMed   Mentions:
    26. PBP4 Mediates ß-Lactam Resistance by Altered Function. Antimicrob Agents Chemother. 2017 11; 61(11). Chatterjee SS, Chen L, Gilbert A, da Costa TM, Nair V, Datta SK, Kreiswirth BN, Chambers HF. PMID: 28807923.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    27. Prevalence of Slow-Growth Vancomycin Nonsusceptibility in Methicillin-Resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2017 11; 61(11). Katayama Y, Azechi T, Miyazaki M, Takata T, Sekine M, Matsui H, Hanaki H, Yahara K, Sasano H, Asakura K, Takaku T, Ochiai T, Komatsu N, Chambers HF. PMID: 28827421.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    28. Antimicrobial Stewardship Approaches in the Intensive Care Unit. Infect Dis Clin North Am. 2017 09; 31(3):513-534. Doernberg SB, Chambers HF. PMID: 28687210.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    29. A Placebo-Controlled Trial of Antibiotics for Smaller Skin Abscesses. N Engl J Med. 2017 06 29; 376(26):2545-2555. Daum RS, Miller LG, Immergluck L, Fritz S, Creech CB, Young D, Kumar N, Downing M, Pettibone S, Hoagland R, Eells SJ, Boyle MG, Parker TC, Chambers HF, DMID 07-0051 Team . PMID: 28657870.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    30. High-Level Resistance of Staphylococcus aureus to ß-Lactam Antibiotics Mediated by Penicillin-Binding Protein 4 (PBP4). Antimicrob Agents Chemother. 2017 06; 61(6). Hamilton SM, Alexander JAN, Choo EJ, Basuino L, da Costa TM, Severin A, Chung M, Aedo S, Strynadka NCJ, Tomasz A, Chatterjee SS, Chambers HF. PMID: 28373193.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    31. Can Ceftazidime-Avibactam and Aztreonam Overcome ß-Lactam Resistance Conferred by Metallo-ß-Lactamases in Enterobacteriaceae? Antimicrob Agents Chemother. 2017 04; 61(4). Marshall S, Hujer AM, Rojas LJ, Papp-Wallace KM, Humphries RM, Spellberg B, Hujer KM, Marshall EK, Rudin SD, Perez F, Wilson BM, Wasserman RB, Chikowski L, Paterson DL, Vila AJ, van Duin D, Kreiswirth BN, Chambers HF, Fowler VG, Jacobs MR, Pulse ME, Weiss WJ, Bonomo RA. PMID: 28167541.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    32. The Antibacterial Resistance Leadership Group: Progress Report and Work in Progress. Clin Infect Dis. 2017 Mar 15; 64(suppl_1):S3-S7. Chambers HF, Cross HR, Evans SR, Kreiswirth BN, Fowler VG, Antibacterial Resistance Leadership Group (ARLG) . PMID: 28350896.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    33. Ceftaroline-Resistant, Daptomycin-Tolerant, and Heterogeneous Vancomycin-Intermediate Methicillin-Resistant Staphylococcus aureus Causing Infective Endocarditis. Antimicrob Agents Chemother. 2017 03; 61(3). Nigo M, Diaz L, Carvajal LP, Tran TT, Rios R, Panesso D, Garavito JD, Miller WR, Wanger A, Weinstock G, Munita JM, Arias CA, Chambers HF. PMID: 28232309.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    34. Treatment of Methicillin-Resistant Staphylococcus aureus Bacteremia. Infect Chemother. 2016 12; 48(4):267-273. Choo EJ, Chambers HF. PMID: 28032484.
      View in: PubMed   Mentions:
    35. IVIG-mediated protection against necrotizing pneumonia caused by MRSA. Sci Transl Med. 2016 09 21; 8(357):357ra124. Diep BA, Le VT, Badiou C, Le HN, Pinheiro MG, Duong AH, Wang X, Dip EC, Aguiar-Alves F, Basuino L, Marbach H, Mai TT, Sarda MN, Kajikawa O, Matute-Bello G, Tkaczyk C, Rasigade JP, Sellman BR, Chambers HF, Lina G. PMID: 27655850.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    36. Vancomycin MIC Does Not Predict 90-Day Mortality, Readmission, or Recurrence in a Prospective Cohort of Adults with Staphylococcus aureus Bacteremia. Antimicrob Agents Chemother. 2016 09; 60(9):5276-84. Baxi SM, Clemenzi-Allen A, Gahbauer A, Deck D, Imp B, Vittinghoff E, Chambers HF, Doernberg S. PMID: 27324762.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    37. PBP 4 Mediates High-Level Resistance to New-Generation Cephalosporins in Staphylococcus aureus. Antimicrob Agents Chemother. 2016 07; 60(7):3934-41. Chan LC, Gilbert A, Basuino L, da Costa TM, Hamilton SM, Dos Santos KR, Chambers HF, Chatterjee SS. PMID: 27067335.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    38. Daptomycin-ß-Lactam Combinations in a Rabbit Model of Daptomycin-Nonsusceptible Methicillin-Resistant Staphylococcus aureus Endocarditis. Antimicrob Agents Chemother. 2016 07; 60(7):3976-9. Chambers HF, Basuino L, Hamilton SM, Choo EJ, Moise P. PMID: 27090173.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    39. Whole-Genome Sequencing of Methicillin-Resistant Staphylococcus aureus Resistant to Fifth-Generation Cephalosporins Reveals Potential Non-mecA Mechanisms of Resistance. PLoS One. 2016; 11(2):e0149541. Greninger AL, Chatterjee SS, Chan LC, Hamilton SM, Chambers HF, Chiu CY. PMID: 26890675.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    40. Comparative efficacies of tedizolid phosphate, vancomycin, and daptomycin in a rabbit model of methicillin-resistant Staphylococcus aureus endocarditis. Antimicrob Agents Chemother. 2015; 59(6):3252-6. Chan LC, Basuino L, Dip EC, Chambers HF. PMID: 25801564.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    41. Clindamycin versus trimethoprim-sulfamethoxazole for uncomplicated skin infections. N Engl J Med. 2015 Mar 19; 372(12):1093-103. Miller LG, Daum RS, Creech CB, Young D, Downing MD, Eells SJ, Pettibone S, Hoagland RJ, Chambers HF, DMID 07-0051 Team . PMID: 25785967.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    42. Ceftobiprole- and ceftaroline-resistant methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2015 May; 59(5):2960-3. Chan LC, Basuino L, Diep B, Hamilton S, Chatterjee SS, Chambers HF. PMID: 25753637.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    43. Probability of eradication using vancomycin alone or in combination for methicillin-resistant Staphylococcus aureus bacteremia. Antimicrob Agents Chemother. 2014 Dec; 58(12):7617. Chambers HF. PMID: 25392536.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    44. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the Infectious Diseases Society of America. Clin Infect Dis. 2014 Jul 15; 59(2):e10-52. Stevens DL, Bisno AL, Chambers HF, Dellinger EP, Goldstein EJ, Gorbach SL, Hirschmann JV, Kaplan SL, Montoya JG, Wade JC, Infectious Diseases Society of America . PMID: 24973422.
      View in: PubMed   Mentions: 303     Fields:    Translation:Humans
    45. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the infectious diseases society of America. Clin Infect Dis. 2014 Jul 15; 59(2):147-59. Stevens DL, Bisno AL, Chambers HF, Dellinger EP, Goldstein EJ, Gorbach SL, Hirschmann JV, Kaplan SL, Montoya JG, Wade JC. PMID: 24947530.
      View in: PubMed   Mentions: 147     Fields:    Translation:Humans
    46. Pharmacology and the treatment of complicated skin and skin-structure infections. N Engl J Med. 2014 Jun 05; 370(23):2238-9. Chambers HF. PMID: 24897088.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    47. Global gene expression of methicillin-resistant Staphylococcus aureus USA300 during human and mouse infection. J Infect Dis. 2014 May 15; 209(10):1542-50. Date SV, Modrusan Z, Lawrence M, Morisaki JH, Toy K, Shah IM, Kim J, Park S, Xu M, Basuino L, Chan L, Zeitschel D, Chambers HF, Tan MW, Brown EJ, Diep BA, Hazenbos WL. PMID: 24286981.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    48. Effects of linezolid on suppressing in vivo production of staphylococcal toxins and improving survival outcomes in a rabbit model of methicillin-resistant Staphylococcus aureus necrotizing pneumonia. J Infect Dis. 2013 Jul; 208(1):75-82. Diep BA, Afasizheva A, Le HN, Kajikawa O, Matute-Bello G, Tkaczyk C, Sellman B, Badiou C, Lina G, Chambers HF. PMID: 23532096.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    49. Epidemiologic Similarities in Pediatric Community-Associated Methicillin-Resistant and Methicillin-Sensitive Staphylococcus aureus in the San Francisco Bay Area. J Pediatric Infect Dis Soc. 2012 Sep; 1(3):200-11. Hsiang MS, Shiau R, Nadle J, Chan L, Lee B, Chambers HF, Pan E. PMID: 23687577.
      View in: PubMed   Mentions: 8     Fields:    
    50. Concurrent epidemics of skin and soft tissue infection and bloodstream infection due to community-associated methicillin-resistant Staphylococcus aureus. Clin Infect Dis. 2012 Sep; 55(6):781-8. Tattevin P, Schwartz BS, Graber CJ, Volinski J, Bhukhen A, Bhukhen A, Mai TT, Vo NH, Dang DN, Phan TH, Basuino L, Perdreau-Remington F, Chambers HF, Diep BA. PMID: 22670044.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCellsPHPublic Health
    51. Does doxycycline protect against development of Clostridium difficile infection? Clin Infect Dis. 2012 Sep; 55(5):615-20. Doernberg SB, Winston LG, Deck DH, Chambers HF. PMID: 22563022.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    52. Genetic pathway in acquisition and loss of vancomycin resistance in a methicillin resistant Staphylococcus aureus (MRSA) strain of clonal type USA300. PLoS Pathog. 2012 Feb; 8(2):e1002505. Gardete S, Kim C, Hartmann BM, Mwangi M, Roux CM, Dunman PM, Chambers HF, Tomasz A. PMID: 22319446.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    53. Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children: executive summary. Clin Infect Dis. 2011 Feb 01; 52(3):285-92. Liu C, Bayer A, Cosgrove SE, Daum RS, Fridkin SK, Gorwitz RJ, Kaplan SL, Karchmer AW, Levine DP, Murray BE, J Rybak M, Talan DA, Chambers HF. PMID: 21217178.
      View in: PubMed   Mentions: 409     Fields:    Translation:HumansCells
    54. Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children. Clin Infect Dis. 2011 Feb 01; 52(3):e18-55. Liu C, Bayer A, Cosgrove SE, Daum RS, Fridkin SK, Gorwitz RJ, Kaplan SL, Karchmer AW, Levine DP, Murray BE, J Rybak M, Talan DA, Chambers HF, Infectious Diseases Society of America . PMID: 21208910.
      View in: PubMed   Mentions: 625     Fields:    Translation:HumansCells
    55. A mecA-negative strain of methicillin-resistant Staphylococcus aureus with high-level ß-lactam resistance contains mutations in three genes. Antimicrob Agents Chemother. 2010 Nov; 54(11):4900-2. Banerjee R, Gretes M, Harlem C, Basuino L, Chambers HF. PMID: 20805396.
      View in: PubMed   Mentions: 44     Fields:    Translation:Cells
    56. Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injury. Proc Natl Acad Sci U S A. 2010 Mar 23; 107(12):5587-92. Diep BA, Chan L, Tattevin P, Kajikawa O, Martin TR, Basuino L, Mai TT, Marbach H, Braughton KR, Whitney AR, Gardner DJ, Fan X, Tseng CW, Liu GY, Badiou C, Etienne J, Lina G, Matthay MA, DeLeo FR, Chambers HF. PMID: 20231457.
      View in: PubMed   Mentions: 165     Fields:    Translation:HumansAnimalsCells
    57. Community-associated meticillin-resistant Staphylococcus aureus. Lancet. 2010 May 01; 375(9725):1557-68. DeLeo FR, Otto M, Kreiswirth BN, Chambers HF. PMID: 20206987.
      View in: PubMed   Mentions: 448     Fields:    Translation:HumansCells
    58. Characterization of baseline methicillin-resistant Staphylococcus aureus isolates recovered from phase IV clinical trial for linezolid. J Clin Microbiol. 2010 Feb; 48(2):568-74. Mendes RE, Sader HS, Deshpande LM, Diep BA, Chambers HF, Jones RN. PMID: 19940054.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCellsCTClinical Trials
    59. Waves of resistance: Staphylococcus aureus in the antibiotic era. Nat Rev Microbiol. 2009 Sep; 7(9):629-41. Chambers HF, Deleo FR. PMID: 19680247.
      View in: PubMed   Mentions: 699     Fields:    Translation:HumansCellsPHPublic Health
    60. Reemergence of antibiotic-resistant Staphylococcus aureus in the genomics era. J Clin Invest. 2009 Sep; 119(9):2464-74. DeLeo FR, Chambers HF. PMID: 19729844.
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    61. Coming home with MRSA. Arch Intern Med. 2009 Aug 10; 169(15):1379-80. Winston L, Chambers H. PMID: 19667300.
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    62. Doxycycline, not minocycline, induces its own resistance in multidrug-resistant, community-associated methicillin-resistant Staphylococcus aureus clone USA300. Clin Infect Dis. 2009 May 15; 48(10):1483-4. Schwartz BS, Graber CJ, Diep BA, Basuino L, Perdreau-Remington F, Chambers HF. PMID: 19374563.
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    63. Subinhibitory fluoroquinolone exposure selects for reduced beta-lactam susceptibility in methicillin-resistant Staphylococcus aureus and alterations in the SOS-mediated response. Res Microbiol. 2009 Apr; 160(3):187-92. Tattevin P, Basuino L, Chambers HF. PMID: 19366630.
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    64. Evolution of virulence in epidemic community-associated methicillin-resistant Staphylococcus aureus. Proc Natl Acad Sci U S A. 2009 Apr 07; 106(14):5883-8. Li M, Diep BA, Villaruz AE, Braughton KR, Jiang X, DeLeo FR, Chambers HF, Lu Y, Otto M. PMID: 19293374.
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    65. Initial low-dose gentamicin for Staphylococcus aureus bacteremia and endocarditis is nephrotoxic. Clin Infect Dis. 2009 Mar 15; 48(6):713-21. Cosgrove SE, Vigliani GA, Fowler VG, Abrutyn E, Corey GR, Levine DP, Rupp ME, Chambers HF, Karchmer AW, Boucher HW. PMID: 19207079.
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    66. Recurrence of skin and soft tissue infection caused by methicillin-resistant Staphylococcus aureus in a HIV primary care clinic. . 2008 Oct 01; 49(2):231-3. Graber CJ, Jacobson MA, Perdreau-Remington F, Chambers HF, Diep BA. PMID: 18820536.
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    67. Contribution of Panton-Valentine leukocidin in community-associated methicillin-resistant Staphylococcus aureus pathogenesis. PLoS One. 2008 Sep 12; 3(9):e3198. Diep BA, Palazzolo-Ballance AM, Tattevin P, Basuino L, Braughton KR, Whitney AR, Chen L, Kreiswirth BN, Otto M, DeLeo FR, Chambers HF. PMID: 18787708.
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    68. Clinical decisions. Management of skin and soft-tissue infection. N Engl J Med. 2008 Sep 04; 359(10):1063-7. Chambers HF, Moellering RC, Kamitsuka P. PMID: 18768953.
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    69. National trends in ambulatory visits and antibiotic prescribing for skin and soft-tissue infections. Arch Intern Med. 2008 Jul 28; 168(14):1585-91. Hersh AL, Chambers HF, Maselli JH, Gonzales R. PMID: 18663172.
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    70. Skin and soft-tissue infections caused by community-acquired methicillin-resistant Staphylococcus aureus. Clin Infect Dis. 2008 Jun 01; 46 Suppl 5:S368-77. Stryjewski ME, Chambers HF. PMID: 18462092.
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    71. The arginine catabolic mobile element and staphylococcal chromosomal cassette mec linkage: convergence of virulence and resistance in the USA300 clone of methicillin-resistant Staphylococcus aureus. J Infect Dis. 2008 Jun 01; 197(11):1523-30. Diep BA, Stone GG, Basuino L, Graber CJ, Miller A, des Etages SA, Jones A, Palazzolo-Ballance AM, Perdreau-Remington F, Sensabaugh GF, DeLeo FR, Chambers HF. PMID: 18700257.
      View in: PubMed   Mentions: 170     Fields:    Translation:AnimalsCells
    72. A population-based study of the incidence and molecular epidemiology of methicillin-resistant Staphylococcus aureus disease in San Francisco, 2004-2005. Clin Infect Dis. 2008 Jun 01; 46(11):1637-46. Liu C, Graber CJ, Karr M, Diep BA, Basuino L, Schwartz BS, Enright MC, O'Hanlon SJ, Thomas JC, Perdreau-Remington F, Gordon S, Gunthorpe H, Jacobs R, Jensen P, Leoung G, Rumack JS, Chambers HF. PMID: 18433335.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansCellsPHPublic Health
    73. In vitro selection and characterization of ceftobiprole-resistant methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2008 Jun; 52(6):2089-96. Banerjee R, Gretes M, Basuino L, Strynadka N, Chambers HF. PMID: 18378703.
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    74. Determining whether methicillin-resistant Staphylococcus aureus is associated with health care. JAMA. 2008 Feb 06; 299(5):519; author reply 519-20. David MZ, Siegel JD, Chambers HF, Daum RS. PMID: 18252879.
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    75. Emergence of multidrug-resistant, community-associated, methicillin-resistant Staphylococcus aureus clone USA300 in men who have sex with men. Ann Intern Med. 2008 Feb 19; 148(4):249-57. Diep BA, Chambers HF, Graber CJ, Szumowski JD, Miller LG, Han LL, Chen JH, Lin F, Lin J, Phan TH, Carleton HA, McDougal LK, Tenover FC, Cohen DE, Mayer KH, Sensabaugh GF, Perdreau-Remington F. PMID: 18283202.
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    76. Randomized, double-blind, placebo-controlled trial of cephalexin for treatment of uncomplicated skin abscesses in a population at risk for community-acquired methicillin-resistant Staphylococcus aureus infection. Antimicrob Agents Chemother. 2007 Nov; 51(11):4044-8. Rajendran PM, Young D, Maurer T, Chambers H, Perdreau-Remington F, Ro P, Harris H. PMID: 17846141.
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    77. Combating the growing problem of methicillin-resistant Staphylococcus aureus: do the newer antibiotics represent a better alternative to vancomycin? Expert Rev Anti Infect Ther. 2007 Jun; 5(3):333-5. Chambers HF, Hegde SS. PMID: 17547497.
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    78. Mechanism of cell surface expression of the Streptococcus mitis platelet binding proteins PblA and PblB. Mol Microbiol. 2007 May; 64(3):844-57. Mitchell J, Siboo IR, Takamatsu D, Chambers HF, Sullam PM. PMID: 17462028.
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    79. Intermediate vancomycin susceptibility in a community-associated MRSA clone. Emerg Infect Dis. 2007 Mar; 13(3):491-3. Graber CJ, Wong MK, Carleton HA, Perdreau-Remington F, Haller BL, Chambers HF. PMID: 17552110.
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    80. Daptomycin versus standard therapy for bacteremia and endocarditis caused by Staphylococcus aureus. N Engl J Med. 2006 Aug 17; 355(7):653-65. Fowler VG, Boucher HW, Corey GR, Abrutyn E, Karchmer AW, Rupp ME, Levine DP, Chambers HF, Tally FP, Vigliani GA, Cabell CH, Link AS, DeMeyer I, Filler SG, Zervos M, Cook P, Parsonnet J, Bernstein JM, Price CS, Forrest GN, Fätkenheuer G, Gareca M, Rehm SJ, Brodt HR, Tice A, Cosgrove SE, S. aureus Endocarditis and Bacteremia Study Group . PMID: 16914701.
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    81. Ophthalmic manifestations of infections caused by the USA300 clone of community-associated methicillin-resistant Staphylococcus aureus. Ophthalmology. 2006 Aug; 113(8):1455-62. Rutar T, Chambers HF, Crawford JB, Perdreau-Remington F, Zwick OM, Karr M, Diehn JJ, Cockerham KP. PMID: 16766029.
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    82. Diabetic ketoacidosis precipitated by Staphylococcus aureus abscess and bacteremia due to acupuncture: case report and review of the literature. Clin Infect Dis. 2006 Jul 01; 43(1):e6-8. Seeley EJ, Chambers HF. PMID: 16758409.
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    83. Practice guidelines for the diagnosis and management of skin and soft-tissue infections. Clin Infect Dis. 2005 Nov 15; 41(10):1373-406. Stevens DL, Bisno AL, Chambers HF, Everett ED, Dellinger P, Goldstein EJ, Gorbach SL, Hirschmann JV, Kaplan EL, Montoya JG, Wade JC, Infectious Diseases Society of America . PMID: 16231249.
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    84. Efficacy of Telavancin in a rabbit model of aortic valve endocarditis due to methicillin-resistant Staphylococcus aureus or vancomycin-intermediate Staphylococcus aureus. Antimicrob Agents Chemother. 2005 Aug; 49(8):3163-5. Madrigal AG, Basuino L, Chambers HF. PMID: 16048918.
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    85. Imipenem for treatment of tuberculosis in mice and humans. Antimicrob Agents Chemother. 2005 Jul; 49(7):2816-21. Chambers HF, Turner J, Schecter GF, Kawamura M, Hopewell PC. PMID: 15980354.
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    86. Low colonization prevalence of Staphylococcus aureus with reduced vancomycin susceptibility among patients undergoing hemodialysis in the San Francisco Bay area. Clin Infect Dis. 2005 Jun 01; 40(11):1617-24. Eguia JM, Liu C, Moore M, Wrone EM, Pont J, Gerberding JL, Chambers HF. PMID: 15889359.
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    87. Role of SraP, a Serine-Rich Surface Protein of Staphylococcus aureus, in binding to human platelets. Infect Immun. 2005 Apr; 73(4):2273-80. Siboo IR, Chambers HF, Sullam PM. PMID: 15784571.
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    88. Evaluation of ceftobiprole in a rabbit model of aortic valve endocarditis due to methicillin-resistant and vancomycin-intermediate Staphylococcus aureus. Antimicrob Agents Chemother. 2005 Mar; 49(3):884-8. Chambers HF. PMID: 15728879.
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    89. An epidemic of methicillin-resistant Staphylococcus aureus soft tissue infections among medically underserved patients. Arch Surg. 2004 Sep; 139(9):947-51; discussion 951-3. Young DM, Harris HW, Charlebois ED, Chambers H, Campbell A, Perdreau-Remington F, Lee C, Mankani M, Mackersie R, Schecter WP. PMID: 15381611.
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    90. Crystal structures of the Apo and penicillin-acylated forms of the BlaR1 beta-lactam sensor of Staphylococcus aureus. J Biol Chem. 2004 Nov 05; 279(45):47278-87. Wilke MS, Hills TL, Zhang HZ, Chambers HF, Strynadka NC. PMID: 15322076.
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    91. Origins of community strains of methicillin-resistant Staphylococcus aureus. Clin Infect Dis. 2004 Jul 01; 39(1):47-54. Charlebois ED, Perdreau-Remington F, Kreiswirth B, Bangsberg DR, Ciccarone D, Diep BA, Ng VL, Chansky K, Edlin BR, Edlin B, Chambers HF. PMID: 15206052.
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    92. API 20 strep identification system may incorrectly speciate enterococci with low level resistance to vancomycin. Diagn Microbiol Infect Dis. 2004 Apr; 48(4):287-8. Winston LG, Pang S, Haller BL, Wong M, Chambers HF, Perdreau-Remington F. PMID: 15062923.
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    93. PBP 2a mutations producing very-high-level resistance to beta-lactams. Antimicrob Agents Chemother. 2004 Feb; 48(2):453-9. Katayama Y, Zhang HZ, Chambers HF. PMID: 14742194.
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    94. Community-acquired Methicillin-resistant Staphylococcus aureus: Epidemiology and Potential Virulence Factors. Curr Infect Dis Rep. 2003 Dec; 5(6):459-466. Eguia JM, Chambers HF. PMID: 14642185.
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    95. Staphylococcus aureus with heterogeneous resistance to vancomycin: epidemiology, clinical significance, and critical assessment of diagnostic methods. Antimicrob Agents Chemother. 2003 Oct; 47(10):3040-5. Liu C, Chambers HF. PMID: 14506006.
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    96. Jumping the barrier to beta-lactam resistance in Staphylococcus aureus. J Bacteriol. 2003 Sep; 185(18):5465-72. Katayama Y, Zhang HZ, Hong D, Chambers HF. PMID: 12949098.
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    97. Vancomycin treatment failure associated with heterogeneous vancomycin-intermediate Staphylococcus aureus in a patient with endocarditis and in the rabbit model of endocarditis. Antimicrob Agents Chemother. 2003 Apr; 47(4):1262-6. Moore MR, Perdreau-Remington F, Chambers HF. PMID: 12654656.
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    98. Solving staphylococcal resistance to beta-lactams. Trends Microbiol. 2003 Apr; 11(4):145-8. Chambers HF. PMID: 12706985.
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    99. Methicillin-resistant staphylococci and their treatment in the intensive care unit. Semin Respir Crit Care Med. 2003 Feb; 24(1):37-48. Eguia JM, Chambers HF. PMID: 16088523.
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    100. Effect of disruption of Staphylococcus aureus PBP4 gene on resistance to beta-lactam antibiotics. Microb Drug Resist. 2003; 9(4):329-36. Katayama Y, Zhang HZ, Chambers HF. PMID: 15000739.
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    101. Epidemiology of vancomycin-resistant Enterococcus faecium under a selective isolation policy at an urban county hospital. Am J Infect Control. 2002 Nov; 30(7):400-6. Winston LG, Bangsberg DR, Chambers HF, Felt SC, Rosen JI, Charlebois ED, Wong M, Steele L, Gerberding JL, Perdreau-Remington F. PMID: 12410216.
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    102. Population-based community prevalence of methicillin-resistant Staphylococcus aureus in the urban poor of San Francisco. Clin Infect Dis. 2002 Feb 15; 34(4):425-33. Charlebois ED, Bangsberg DR, Moss NJ, Moore MR, Moss AR, Chambers HF, Perdreau-Remington F. PMID: 11797167.
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