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Henry Chambers, III, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address1001 Potrero Ave
San Francisco CA 94110
Phone628-206-5437
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    Other Positions
    Title(s)Chief, Division of Infectious Diseases, SFGH

    Title(s)Director, Clinical Research Services, CTSI


    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency School of Medicine
    Vanderbilt UniversityM.D.School of Medicine
    Centre College Kentucky B.A.

    Collapse Overview 
    Collapse Overview
    Dr. Chambers clinical and research interests are antimicrobial drug resistance, staphylococcal infections, experimental therapeutics, and epidemiology and pathogenesis of disease caused by Staphylococcus aureus. He is editor for the Sanford Guide to Antimicrobial Therapy and he has over 200 original publications and textbook chapters in the areas of drug resistance, endocarditis, bacterial infections, and staphylococcal diseases.

    Dr. Chambers received his BA from Centre College in Kentucky and is a graduate of the Vanderbilt University School of Medicine. He trained in Internal Medicine and Infectious Diseases at the University of California San Francisco. Dr. Chambers has been a member of the medical faculty of the UCSF since 1983 where he currently is Professor of Medicine, Medical Director of Clinical Research Services for CTSI. He is an editor for Antimicrobial Agents and Chemotherapy, a reviewer for numerous medical publications, a peer reviewer for NIH study sections.

    Collapse Research 
    Collapse Research Activities and Funding
    Antibacterial Resistance Leadership Group (ARLG)
    NIH/NIAID UM1AI104681Jun 1, 2013 - Nov 30, 2026
    Role: Co-Principal Investigator
    Novel Mechanisms of Beta-lactam Resistance in Staph Aureus
    NIH/NIAID R01AI100291Aug 1, 2012 - Nov 30, 2016
    Role: Principal Investigator
    Novel Mechanisms of Beta-lactam Resistance in Staph Aureus
    NIH/NIAID R56AI100291Aug 1, 2012 - Nov 30, 2012
    Role: Principal Investigator
    Genetic Basis of Virulence of Community MRSA Clone USA300
    NIH/NIAID R01AI070289Apr 1, 2008 - Mar 31, 2012
    Role: Principal Investigator
    Gordon Research Conference on Staphylococcal Diseases
    NIH/NIAID R13AI050556Jul 1, 2001 - Jun 30, 2002
    Role: Principal Investigator
    Biology of Infectious Diseases Training Program
    NIH/NIAID T32AI007641Aug 1, 2000 - Jul 31, 2006
    Role: Principal Investigator
    PENICILLIN INTERACTIVE PROTEINS OF STAPHYLOCOCCUS AUREUS
    NIH/NIAID R01AI046610Feb 1, 2000 - Jan 31, 2005
    Role: Principal Investigator
    GORDON CONFERENCE ON STAPHYLOCOCCAL DISEASES
    NIH/NIAID R13AI043943May 1, 1999 - Apr 30, 2000
    Role: Principal Investigator
    VANCOMYCIN-RESISTANT STAPHYLOCOCCUS AUREUS
    NIH/NIAID R03AI043959Apr 1, 1999 - Mar 31, 2002
    Role: Principal Investigator
    PENICILLIN BINDING PROTEINS OF STAPHYLOCOCCUS AUREUS
    NIH/NIAID R21AI032496Sep 30, 1996 - Sep 29, 1999
    Role: Principal Investigator
    DEVELOPMENT OF DRUGS FOR TREATING TUBERCULOSIS
    NIH/NIAID R01AI033702Sep 30, 1992 - Aug 31, 1997
    Role: Principal Investigator
    METHICILLIN RESISTANCE OF STAPHYLOCOCCUS AUREUS
    NIH/NIAID R29AI027406Dec 1, 1988 - Nov 30, 1993
    Role: Principal Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000083Oct 1, 1974 - Sep 29, 2006
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Global Health
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Native-Valve Infective Endocarditis. N Engl J Med. 2020 08 06; 383(6):567-576. Chambers HF, Bayer AS. PMID: 32757525.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Rifabutin to the Rescue? J Infect Dis. 2020 Jul 07. Chambers HF. PMID: 32914842.
      View in: PubMed   Mentions:    Fields:    
    3. Differential Trends in Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Infections in Four Health Care Facilities in a Single Metropolitan Area: A Retrospective Analysis. Microb Drug Resist. 2020 Jun 23. Raphael E, Chambers HF. PMID: 32589493.
      View in: PubMed   Mentions:    Fields:    
    4. Structural analysis of avibactam-mediated activation of the bla and mec divergons in methicillin-resistant Staphylococcus aureus. J Biol Chem. 2020 Aug 07; 295(32):10870-10884. Alexander JAN, Radaeva M, King DT, Chambers HF, Cherkasov A, Chatterjee SS, Strynadka NCJ. PMID: 32518158.
      View in: PubMed   Mentions:    Fields:    
    5. Scope and Predictive Genetic/Phenotypic Signatures of Bicarbonate (NaHCO3) Responsiveness and ß-Lactam Sensitization in Methicillin-Resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2020 04 21; 64(5). Ersoy SC, Otmishi M, Milan VT, Li L, Pak Y, Mediavilla J, Chen L, Kreiswirth B, Chambers HF, Proctor RA, Xiong YQ, Fowler VG, Bayer AS. PMID: 32041719.
      View in: PubMed   Mentions: 1     Fields:    
    6. The Emperor's New Clothes: PRospective Observational Evaluation of the Association Between Initial VancomycIn Exposure and Failure Rates Among ADult HospitalizEd Patients With Methicillin-resistant Staphylococcus aureus Bloodstream Infections (PROVIDE). Clin Infect Dis. 2020 Apr 10; 70(8):1536-1545. Lodise TP, Rosenkranz SL, Finnemeyer M, Evans S, Sims M, Zervos MJ, Creech CB, Patel PC, Keefer M, Riska P, Silveira FP, Scheetz M, Wunderink RG, Rodriguez M, Schrank J, Bleasdale SC, Schultz S, Barron M, Stapleton A, Wray D, Chambers H, Fowler VG, Holland TL. PMID: 31157370.
      View in: PubMed   Mentions: 4     Fields:    
    7. Analytical Evaluation of the Abbott RealTime CT/NG Assay for Detection of Chlamydia trachomatis and Neisseria gonorrhoeae in Rectal and Pharyngeal Swabs. J Mol Diagn. 2020 Jun; 22(6):811-816. Adamson PC, Pandori MW, Doernberg SB, Komarow L, Sund Z, Tran TTT, Jensen D, Tsalik EL, Deal CD, Chambers HF, Fowler VG, Evans SR, Patel R, Klausner JD. PMID: 32247863.
      View in: PubMed   Mentions:    Fields:    
    8. Ability of Bicarbonate Supplementation To Sensitize Selected Methicillin-Resistant Staphylococcus aureus Strains to ß-Lactam Antibiotics in an Ex Vivo Simulated Endocardial Vegetation Model. Antimicrob Agents Chemother. 2020 02 21; 64(3). Rose WE, Bienvenida AM, Xiong YQ, Chambers HF, Bayer AS, Ersoy SC. PMID: 31844004.
      View in: PubMed   Mentions: 2     Fields:    
    9. Is Daptomycin plus Ceftaroline Associated with Better Clinical Outcomes than Standard of Care Monotherapy for Staphylococcus aureus Bacteremia? Antimicrob Agents Chemother. 2019 11; 63(11). Kalil AC, Holubar M, Deresinski S, Chambers HF. PMID: 31640977.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    10. Bicarbonate Resensitization of Methicillin-Resistant Staphylococcus aureus to ß-Lactam Antibiotics. Antimicrob Agents Chemother. 2019 07; 63(7). Ersoy SC, Abdelhady W, Li L, Chambers HF, Xiong YQ, Bayer AS. PMID: 31010857.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    11. Good Studies Evaluate the Disease While Great Studies Evaluate the Patient: Development and Application of a Desirability of Outcome Ranking Endpoint for Staphylococcus aureus Bloodstream Infection. Clin Infect Dis. 2019 05 02; 68(10):1691-1698. Doernberg SB, Tran TTT, Tong SYC, Paul M, Yahav D, Davis JS, Leibovici L, Boucher HW, Corey GR, Cosgrove SE, Chambers HF, Fowler VG, Evans SR, Holland TL. PMID: 30321315.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    12. A Prognostic Model of Persistent Bacteremia and Mortality in Complicated Staphylococcus aureus Bloodstream Infection. Clin Infect Dis. 2019 04 24; 68(9):1502-1511. Guimaraes AO, Cao Y, Hong K, Mayba O, Peck MC, Gutierrez J, Ruffin F, Carrasco-Triguero M, Dinoso JB, Clemenzi-Allen A, Koss CA, Maskarinec SA, Chambers HF, Fowler VG, Baruch A, Rosenberger CM. PMID: 30165412.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    13. Omadacycline - The Newest Tetracycline. N Engl J Med. 2019 02 07; 380(6):588-589. Chambers HF. PMID: 30726683.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    14. Structural and kinetic analyses of penicillin-binding protein 4 (PBP4)-mediated antibiotic resistance in Staphylococcus aureus. J Biol Chem. 2018 12 21; 293(51):19854-19865. Alexander JAN, Chatterjee SS, Hamilton SM, Eltis LD, Chambers HF, Strynadka NCJ. PMID: 30366985.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    15. Essential Resources and Strategies for Antibiotic Stewardship Programs in the Acute Care Setting. Clin Infect Dis. 2018 09 28; 67(8):1168-1174. Doernberg SB, Abbo LM, Burdette SD, Fishman NO, Goodman EL, Kravitz GR, Leggett JE, Moehring RW, Newland JG, Robinson PA, Spivak ES, Tamma PD, Chambers HF. PMID: 29590355.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    16. PBP4: A New Perspective on Staphylococcus aureus ß-Lactam Resistance. Microorganisms. 2018 06 22; 6(3). da Costa TM, de Oliveira CR, Chambers HF, Chatterjee SS. PMID: 29932109.
      View in: PubMed   Mentions:
    17. PBP4 activity and its overexpression are necessary for PBP4-mediated high-level ß-lactam resistance. J Antimicrob Chemother. 2018 05 01; 73(5):1177-1180. Basuino L, Jousselin A, Alexander JAN, Strynadka NCJ, Pinho MG, Chambers HF, Chatterjee SS. PMID: 29360990.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    18. Prevalence of Slow-Growth Vancomycin Nonsusceptibility in Methicillin-Resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2017 11; 61(11). Katayama Y, Azechi T, Miyazaki M, Takata T, Sekine M, Matsui H, Hanaki H, Yahara K, Sasano H, Asakura K, Takaku T, Ochiai T, Komatsu N, Chambers HF. PMID: 28827421.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    19. PBP4 Mediates ß-Lactam Resistance by Altered Function. Antimicrob Agents Chemother. 2017 11; 61(11). Chatterjee SS, Chen L, Gilbert A, da Costa TM, Nair V, Datta SK, Kreiswirth BN, Chambers HF. PMID: 28807923.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    20. Antimicrobial Stewardship Approaches in the Intensive Care Unit. Infect Dis Clin North Am. 2017 09; 31(3):513-534. Doernberg SB, Chambers HF. PMID: 28687210.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    21. A Placebo-Controlled Trial of Antibiotics for Smaller Skin Abscesses. N Engl J Med. 2017 06 29; 376(26):2545-2555. Daum RS, Miller LG, Immergluck L, Fritz S, Creech CB, Young D, Kumar N, Downing M, Pettibone S, Hoagland R, Eells SJ, Boyle MG, Parker TC, Chambers HF. PMID: 28657870.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    22. High-Level Resistance of Staphylococcus aureus to ß-Lactam Antibiotics Mediated by Penicillin-Binding Protein 4 (PBP4). Antimicrob Agents Chemother. 2017 06; 61(6). Hamilton SM, Alexander JAN, Choo EJ, Basuino L, da Costa TM, Severin A, Chung M, Aedo S, Strynadka NCJ, Tomasz A, Chatterjee SS, Chambers HF. PMID: 28373193.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    23. Can Ceftazidime-Avibactam and Aztreonam Overcome ß-Lactam Resistance Conferred by Metallo-ß-Lactamases in Enterobacteriaceae? Antimicrob Agents Chemother. 2017 04; 61(4). Marshall S, Hujer AM, Rojas LJ, Papp-Wallace KM, Humphries RM, Spellberg B, Hujer KM, Marshall EK, Rudin SD, Perez F, Wilson BM, Wasserman RB, Chikowski L, Paterson DL, Vila AJ, van Duin D, Kreiswirth BN, Chambers HF, Fowler VG, Jacobs MR, Pulse ME, Weiss WJ, Bonomo RA. PMID: 28167541.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    24. The Antibacterial Resistance Leadership Group: Progress Report and Work in Progress. Clin Infect Dis. 2017 Mar 15; 64(suppl_1):S3-S7. Chambers HF, Cross HR, Evans SR, Kreiswirth BN, Fowler VG. PMID: 28350896.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    25. Ceftaroline-Resistant, Daptomycin-Tolerant, and Heterogeneous Vancomycin-Intermediate Methicillin-Resistant Staphylococcus aureus Causing Infective Endocarditis. Antimicrob Agents Chemother. 2017 03; 61(3). Nigo M, Diaz L, Carvajal LP, Tran TT, Rios R, Panesso D, Garavito JD, Miller WR, Wanger A, Weinstock G, Munita JM, Arias CA, Chambers HF. PMID: 28232309.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    26. Treatment of Methicillin-Resistant Staphylococcus aureus Bacteremia. Infect Chemother. 2016 12; 48(4):267-273. Choo EJ, Chambers HF. PMID: 28032484.
      View in: PubMed   Mentions:
    27. IVIG-mediated protection against necrotizing pneumonia caused by MRSA. Sci Transl Med. 2016 09 21; 8(357):357ra124. Diep BA, Le VT, Badiou C, Le HN, Pinheiro MG, Duong AH, Wang X, Dip EC, Aguiar-Alves F, Basuino L, Marbach H, Mai TT, Sarda MN, Kajikawa O, Matute-Bello G, Tkaczyk C, Rasigade JP, Sellman BR, Chambers HF, Lina G. PMID: 27655850.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    28. Vancomycin MIC Does Not Predict 90-Day Mortality, Readmission, or Recurrence in a Prospective Cohort of Adults with Staphylococcus aureus Bacteremia. Antimicrob Agents Chemother. 2016 09; 60(9):5276-84. Baxi SM, Clemenzi-Allen A, Gahbauer A, Deck D, Imp B, Vittinghoff E, Chambers HF, Doernberg S. PMID: 27324762.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    29. Cefazolin versus Nafcillin for Methicillin-Sensitive Staphylococcus aureus Bloodstream Infection in a California Tertiary Medical Center. Antimicrob Agents Chemother. 2016 08; 60(8):4684-9. Pollett S, Baxi SM, Rutherford GW, Doernberg SB, Bacchetti P, Chambers HF. PMID: 27216053.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    30. PBP 4 Mediates High-Level Resistance to New-Generation Cephalosporins in Staphylococcus aureus. Antimicrob Agents Chemother. 2016 07; 60(7):3934-41. Chan LC, Gilbert A, Basuino L, da Costa TM, Hamilton SM, Dos Santos KR, Chambers HF, Chatterjee SS. PMID: 27067335.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    31. Daptomycin-ß-Lactam Combinations in a Rabbit Model of Daptomycin-Nonsusceptible Methicillin-Resistant Staphylococcus aureus Endocarditis. Antimicrob Agents Chemother. 2016 07; 60(7):3976-9. Chambers HF, Basuino L, Hamilton SM, Choo EJ, Moise P. PMID: 27090173.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    32. Whole-Genome Sequencing of Methicillin-Resistant Staphylococcus aureus Resistant to Fifth-Generation Cephalosporins Reveals Potential Non-mecA Mechanisms of Resistance. PLoS One. 2016; 11(2):e0149541. Greninger AL, Chatterjee SS, Chan LC, Hamilton SM, Chambers HF, Chiu CY. PMID: 26890675.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    33. Comparative efficacies of tedizolid phosphate, vancomycin, and daptomycin in a rabbit model of methicillin-resistant Staphylococcus aureus endocarditis. Antimicrob Agents Chemother. 2015; 59(6):3252-6. Chan LC, Basuino L, Dip EC, Chambers HF. PMID: 25801564.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    34. Clindamycin versus trimethoprim-sulfamethoxazole for uncomplicated skin infections. N Engl J Med. 2015 Mar 19; 372(12):1093-103. Miller LG, Daum RS, Creech CB, Young D, Downing MD, Eells SJ, Pettibone S, Hoagland RJ, Chambers HF. PMID: 25785967.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    35. Ceftobiprole- and ceftaroline-resistant methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2015 May; 59(5):2960-3. Chan LC, Basuino L, Diep B, Hamilton S, Chatterjee SS, Chambers HF. PMID: 25753637.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    36. Probability of eradication using vancomycin alone or in combination for methicillin-resistant Staphylococcus aureus bacteremia. Antimicrob Agents Chemother. 2014 Dec; 58(12):7617. Chambers HF. PMID: 25392536.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    37. Pharmacology and the treatment of complicated skin and skin-structure infections. N Engl J Med. 2014 Jun 05; 370(23):2238-9. Chambers HF. PMID: 24897088.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    38. Global gene expression of methicillin-resistant Staphylococcus aureus USA300 during human and mouse infection. J Infect Dis. 2014 May 15; 209(10):1542-50. Date SV, Modrusan Z, Lawrence M, Morisaki JH, Toy K, Shah IM, Kim J, Park S, Xu M, Basuino L, Chan L, Zeitschel D, Chambers HF, Tan MW, Brown EJ, Diep BA, Hazenbos WL. PMID: 24286981.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    39. Effects of linezolid on suppressing in vivo production of staphylococcal toxins and improving survival outcomes in a rabbit model of methicillin-resistant Staphylococcus aureus necrotizing pneumonia. J Infect Dis. 2013 Jul; 208(1):75-82. Diep BA, Afasizheva A, Le HN, Kajikawa O, Matute-Bello G, Tkaczyk C, Sellman B, Badiou C, Lina G, Chambers HF. PMID: 23532096.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    40. Epidemiologic Similarities in Pediatric Community-Associated Methicillin-Resistant and Methicillin-Sensitive Staphylococcus aureus in the San Francisco Bay Area. J Pediatric Infect Dis Soc. 2012 Sep; 1(3):200-11. Hsiang MS, Shiau R, Nadle J, Chan L, Lee B, Chambers HF, Pan E. PMID: 23687577.
      View in: PubMed   Mentions: 5     Fields:    
    41. Concurrent epidemics of skin and soft tissue infection and bloodstream infection due to community-associated methicillin-resistant Staphylococcus aureus. Clin Infect Dis. 2012 Sep; 55(6):781-8. Tattevin P, Schwartz BS, Graber CJ, Volinski J, Bhukhen A, Bhukhen A, Mai TT, Vo NH, Dang DN, Phan TH, Basuino L, Perdreau-Remington F, Chambers HF, Diep BA. PMID: 22670044.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCellsPHPublic Health
    42. Does doxycycline protect against development of Clostridium difficile infection? Clin Infect Dis. 2012 Sep; 55(5):615-20. Doernberg SB, Winston LG, Deck DH, Chambers HF. PMID: 22563022.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    43. Genetic pathway in acquisition and loss of vancomycin resistance in a methicillin resistant Staphylococcus aureus (MRSA) strain of clonal type USA300. PLoS Pathog. 2012 Feb; 8(2):e1002505. Gardete S, Kim C, Hartmann BM, Mwangi M, Roux CM, Dunman PM, Chambers HF, Tomasz A. PMID: 22319446.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    44. Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children: executive summary. Clin Infect Dis. 2011 Feb 01; 52(3):285-92. Liu C, Bayer A, Cosgrove SE, Daum RS, Fridkin SK, Gorwitz RJ, Kaplan SL, Karchmer AW, Levine DP, Murray BE, J Rybak M, Talan DA, Chambers HF. PMID: 21217178.
      View in: PubMed   Mentions: 372     Fields:    Translation:HumansCells
    45. Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children. Clin Infect Dis. 2011 Feb 01; 52(3):e18-55. Liu C, Bayer A, Cosgrove SE, Daum RS, Fridkin SK, Gorwitz RJ, Kaplan SL, Karchmer AW, Levine DP, Murray BE, J Rybak M, Talan DA, Chambers HF. PMID: 21208910.
      View in: PubMed   Mentions: 550     Fields:    Translation:HumansCells
    46. A mecA-negative strain of methicillin-resistant Staphylococcus aureus with high-level ß-lactam resistance contains mutations in three genes. Antimicrob Agents Chemother. 2010 Nov; 54(11):4900-2. Banerjee R, Gretes M, Harlem C, Basuino L, Chambers HF. PMID: 20805396.
      View in: PubMed   Mentions: 35     Fields:    Translation:Cells
    47. Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injury. Proc Natl Acad Sci U S A. 2010 Mar 23; 107(12):5587-92. Diep BA, Chan L, Tattevin P, Kajikawa O, Martin TR, Basuino L, Mai TT, Marbach H, Braughton KR, Whitney AR, Gardner DJ, Fan X, Tseng CW, Liu GY, Badiou C, Etienne J, Lina G, Matthay MA, DeLeo FR, Chambers HF. PMID: 20231457.
      View in: PubMed   Mentions: 147     Fields:    Translation:HumansAnimalsCells
    48. Community-associated meticillin-resistant Staphylococcus aureus. Lancet. 2010 May 01; 375(9725):1557-68. DeLeo FR, Otto M, Kreiswirth BN, Chambers HF. PMID: 20206987.
      View in: PubMed   Mentions: 421     Fields:    Translation:HumansCells
    49. Characterization of baseline methicillin-resistant Staphylococcus aureus isolates recovered from phase IV clinical trial for linezolid. J Clin Microbiol. 2010 Feb; 48(2):568-74. Mendes RE, Sader HS, Deshpande LM, Diep BA, Chambers HF, Jones RN. PMID: 19940054.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCellsCTClinical Trials
    50. Ceftobiprole is superior to vancomycin, daptomycin, and linezolid for treatment of experimental endocarditis in rabbits caused by methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2010 Feb; 54(2):610-3. Tattevin P, Basuino L, Bauer D, Diep BA, Chambers HF. PMID: 19917746.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    51. Waves of resistance: Staphylococcus aureus in the antibiotic era. Nat Rev Microbiol. 2009 Sep; 7(9):629-41. Chambers HF, Deleo FR. PMID: 19680247.
      View in: PubMed   Mentions: 603     Fields:    Translation:HumansCellsPHPublic Health
    52. Reemergence of antibiotic-resistant Staphylococcus aureus in the genomics era. J Clin Invest. 2009 Sep; 119(9):2464-74. DeLeo FR, Chambers HF. PMID: 19729844.
      View in: PubMed   Mentions: 147     Fields:    Translation:HumansCellsPHPublic Health
    53. Coming home with MRSA. Arch Intern Med. 2009 Aug 10; 169(15):1379-80. Winston L, Chambers H. PMID: 19667300.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    54. Doxycycline, not minocycline, induces its own resistance in multidrug-resistant, community-associated methicillin-resistant Staphylococcus aureus clone USA300. Clin Infect Dis. 2009 May 15; 48(10):1483-4. Schwartz BS, Graber CJ, Diep BA, Basuino L, Perdreau-Remington F, Chambers HF. PMID: 19374563.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    55. Subinhibitory fluoroquinolone exposure selects for reduced beta-lactam susceptibility in methicillin-resistant Staphylococcus aureus and alterations in the SOS-mediated response. Res Microbiol. 2009 Apr; 160(3):187-92. Tattevin P, Basuino L, Chambers HF. PMID: 19366630.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    56. Evolution of virulence in epidemic community-associated methicillin-resistant Staphylococcus aureus. Proc Natl Acad Sci U S A. 2009 Apr 07; 106(14):5883-8. Li M, Diep BA, Villaruz AE, Braughton KR, Jiang X, DeLeo FR, Chambers HF, Lu Y, Otto M. PMID: 19293374.
      View in: PubMed   Mentions: 181     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    57. Initial low-dose gentamicin for Staphylococcus aureus bacteremia and endocarditis is nephrotoxic. Clin Infect Dis. 2009 Mar 15; 48(6):713-21. Cosgrove SE, Vigliani GA, Fowler VG, Abrutyn E, Corey GR, Levine DP, Rupp ME, Chambers HF, Karchmer AW, Boucher HW. PMID: 19207079.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    58. Relationship between susceptibility to daptomycin in vitro and activity in vivo in a rabbit model of aortic valve endocarditis. Antimicrob Agents Chemother. 2009 Apr; 53(4):1463-7. Chambers HF, Basuino L, Diep BA, Steenbergen J, Zhang S, Tattevin P, Alder J. PMID: 19171803.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    59. Recurrence of skin and soft tissue infection caused by methicillin-resistant Staphylococcus aureus in a HIV primary care clinic. . 2008 Oct 01; 49(2):231-3. Graber CJ, Jacobson MA, Perdreau-Remington F, Chambers HF, Diep BA. PMID: 18820536.
      View in: PubMed   Mentions:
    60. Contribution of Panton-Valentine leukocidin in community-associated methicillin-resistant Staphylococcus aureus pathogenesis. PLoS One. 2008 Sep 12; 3(9):e3198. Diep BA, Palazzolo-Ballance AM, Tattevin P, Basuino L, Braughton KR, Whitney AR, Chen L, Kreiswirth BN, Otto M, DeLeo FR, Chambers HF. PMID: 18787708.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
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    74. Efficacy of Telavancin in a rabbit model of aortic valve endocarditis due to methicillin-resistant Staphylococcus aureus or vancomycin-intermediate Staphylococcus aureus. Antimicrob Agents Chemother. 2005 Aug; 49(8):3163-5. Madrigal AG, Basuino L, Chambers HF. PMID: 16048918.
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    75. Imipenem for treatment of tuberculosis in mice and humans. Antimicrob Agents Chemother. 2005 Jul; 49(7):2816-21. Chambers HF, Turner J, Schecter GF, Kawamura M, Hopewell PC. PMID: 15980354.
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    76. Low colonization prevalence of Staphylococcus aureus with reduced vancomycin susceptibility among patients undergoing hemodialysis in the San Francisco Bay area. Clin Infect Dis. 2005 Jun 01; 40(11):1617-24. Eguia JM, Liu C, Moore M, Wrone EM, Pont J, Gerberding JL, Chambers HF. PMID: 15889359.
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    79. Impact of a formulary switch from ticarcillin-clavulanate to piperacillin-tazobactam on colonization with vancomycin-resistant enterococci. Am J Infect Control. 2004 Dec; 32(8):462-9. Winston LG, Charlebois ED, Pang S, Bangsberg DR, Perdreau-Remington F, Chambers HF. PMID: 15573053.
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    81. Crystal structures of the Apo and penicillin-acylated forms of the BlaR1 beta-lactam sensor of Staphylococcus aureus. J Biol Chem. 2004 Nov 05; 279(45):47278-87. Wilke MS, Hills TL, Zhang HZ, Chambers HF, Strynadka NC. PMID: 15322076.
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    82. Origins of community strains of methicillin-resistant Staphylococcus aureus. Clin Infect Dis. 2004 Jul 01; 39(1):47-54. Charlebois ED, Perdreau-Remington F, Kreiswirth B, Bangsberg DR, Ciccarone D, Diep BA, Ng VL, Chansky K, Edlin BR, Edlin B, Chambers HF. PMID: 15206052.
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    83. API 20 strep identification system may incorrectly speciate enterococci with low level resistance to vancomycin. Diagn Microbiol Infect Dis. 2004 Apr; 48(4):287-8. Winston LG, Pang S, Haller BL, Wong M, Chambers HF, Perdreau-Remington F. PMID: 15062923.
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    84. PBP 2a mutations producing very-high-level resistance to beta-lactams. Antimicrob Agents Chemother. 2004 Feb; 48(2):453-9. Katayama Y, Zhang HZ, Chambers HF. PMID: 14742194.
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    94. Identifying pulmonary tuberculosis in patients with negative sputum smear results. Chest. 2001 Aug; 120(2):349-55. Kanaya AM, Glidden DV, Chambers HF. PMID: 11502628.
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    95. A proteolytic transmembrane signaling pathway and resistance to beta-lactams in staphylococci. Science. 2001 Mar 09; 291(5510):1962-5. Zhang HZ, Hackbarth CJ, Chansky KM, Chambers HF. PMID: 11239156.
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    98. Efficacy of levofloxacin for experimental aortic-valve endocarditis in rabbits infected with viridans group streptococcus or Staphylococcus aureus. Antimicrob Agents Chemother. 1999 Nov; 43(11):2742-6. Chambers HF, Xiang Q, Chow LL, Hackbarth C. PMID: 10543757.
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    99. Comparative efficacy of trovafloxacin in experimental endocarditis caused by ciprofloxacin-sensitive, methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 1998 Dec; 42(12):3325-7. Kim YS, Liu Q, Chow LL, Chambers HF, Täuber MG. PMID: 9835540.
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    100. Suppurative parotitis. West J Med. 1998 Aug; 169(2):116-7. Sheppard DC, Chambers HF. PMID: 9735697.
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    101. Activity of amoxicillin/clavulanate in patients with tuberculosis. Clin Infect Dis. 1998 Apr; 26(4):874-7. Chambers HF, Kocagöz T, Sipit T, Turner J, Hopewell PC. PMID: 9564467.
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    102. Cloning and sequence analysis of a class A beta-lactamase from Mycobacterium tuberculosis H37Ra. Antimicrob Agents Chemother. 1997 May; 41(5):1182-5. Hackbarth CJ, Unsal I, Chambers HF. PMID: 9145897.
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    103. Burden of Mycobacterium tuberculosis in sputum samples can be reliably determined using a quantitative, non-radioactive polymerase chain reaction assay. Tuber Lung Dis. 1996 Dec; 77(6):496-501. Sweet-Cordero EA, Chambers HF, Cicero-Sabido R, Santos-Preciado JI. PMID: 9039441.
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    104. Gyrase mutations in laboratory-selected, fluoroquinolone-resistant mutants of Mycobacterium tuberculosis H37Ra. Antimicrob Agents Chemother. 1996 Aug; 40(8):1768-74. Kocagöz T, Hackbarth CJ, Unsal I, Rosenberg EY, Nikaido H, Chambers HF. PMID: 8843279.
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    105. Treatment of Staphylococcus aureus catheter-related infection and infective endocarditis with granulocyte colony-stimulating factor in the experimental rabbit model. Antimicrob Agents Chemother. 1996 May; 40(5):1308-10. Frank U, Chambers HF. PMID: 8723492.
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    106. Atovaquone inhibits the glucuronidation and increases the plasma concentrations of zidovudine. Clin Pharmacol Ther. 1996 Jan; 59(1):14-21. Lee BL, Täuber MG, Sadler B, Goldstein D, Chambers HF. PMID: 8549029.
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    107. Can penicillins and other beta-lactam antibiotics be used to treat tuberculosis? Antimicrob Agents Chemother. 1995 Dec; 39(12):2620-4. Chambers HF, Moreau D, Yajko D, Miick C, Wagner C, Hackbarth C, Kocagöz S, Rosenberg E, Hadley WK, Nikaido H. PMID: 8592990.
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    108. Quantitative culture of Mycobacterium tuberculosis from clinical sputum specimens and dilution endpoint of its detection by the Amplicor PCR assay. J Clin Microbiol. 1995 Jul; 33(7):1944-7. Yajko DM, Wagner C, Tevere VJ, Kocagöz T, Hadley WK, Chambers HF. PMID: 7665679.
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    109. Ampicillin, sulbactam, and rifampin combination treatment of experimental methicillin-resistant Staphylococcus aureus endocarditis in rabbits. J Infect Dis. 1995 Apr; 171(4):897-902. Chambers HF, Kartalija M, Sande M. PMID: 7706817.
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    110. In vitro and in vivo antistaphylococcal activities of L-695,256, a carbapenem with high affinity for the penicillin-binding protein PBP 2a. Antimicrob Agents Chemother. 1995 Feb; 39(2):462-6. Chambers HF. PMID: 7726516.
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    111. Point mutations in Staphylococcus aureus PBP 2 gene affect penicillin-binding kinetics and are associated with resistance. Antimicrob Agents Chemother. 1995 Jan; 39(1):103-6. Hackbarth CJ, Kocagoz T, Kocagoz S, Chambers HF. PMID: 7695289.
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    112. Altered production of penicillin-binding protein 2a can affect phenotypic expression of methicillin resistance in Staphylococcus aureus. Antimicrob Agents Chemother. 1994 Nov; 38(11):2568-71. Hackbarth CJ, Miick C, Chambers HF. PMID: 7872749.
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    113. Efficacy of cefoperazone in combination with sulbactam in experimental Staphylococcus aureus endocarditis in rabbits. J Antimicrob Chemother. 1993 Sep; 32(3):453-8. Chambers HF, Fournier MA. PMID: 8262867.
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    114. Detection of methicillin-resistant staphylococci. Infect Dis Clin North Am. 1993 Jun; 7(2):425-33. Chambers HF. PMID: 8345177.
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    115. blaI and blaR1 regulate beta-lactamase and PBP 2a production in methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 1993 May; 37(5):1144-9. Hackbarth CJ, Chambers HF. PMID: 8517704.
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    116. Short-course combination and oral therapies of Staphylococcus aureus endocarditis. Infect Dis Clin North Am. 1993 Mar; 7(1):69-80. Chambers HF. PMID: 8463654.
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    117. Studies of RP 59500 in vitro and in a rabbit model of aortic valve endocarditis caused by methicillin-resistant Staphylococcus aureus. J Antimicrob Chemother. 1992 Jul; 30 Suppl A:117-22. Chambers HF. PMID: 1399943.
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    118. Characterization of penicillin-binding protein 2 of Staphylococcus aureus: deacylation reaction and identification of two penicillin-binding peptides. Antimicrob Agents Chemother. 1992 Mar; 36(3):656-61. Chambers HF, Miick C. PMID: 1622180.
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    119. Effect of protein binding of daptomycin on MIC and antibacterial activity. Antimicrob Agents Chemother. 1991 Dec; 35(12):2505-8. Lee BL, Sachdeva M, Chambers HF. PMID: 1667253.
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    120. Comparison of conventional susceptibility tests with direct detection of penicillin-binding protein 2a in borderline oxacillin-resistant strains of Staphylococcus aureus. Antimicrob Agents Chemother. 1991 Dec; 35(12):2574-9. Gerberding JL, Miick C, Liu HH, Chambers HF. PMID: 1810191.
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    121. Borderline susceptibility to antistaphylococcal penicillins is not conferred exclusively by the hyperproduction of beta-lactamase. Antimicrob Agents Chemother. 1991 Oct; 35(10):1975-9. Barg N, Chambers H, Kernodle D. PMID: 1759816.
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    122. Treatment of infection and colonization caused by methicillin-resistant Staphylococcus aureus. Infect Control Hosp Epidemiol. 1991 Jan; 12(1):29-35. Chambers HF. PMID: 1847961.
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    123. Characterization of mechanisms of resistance to beta-lactam antibiotics in methicillin-resistant strains of Staphylococcus saprophyticus. Antimicrob Agents Chemother. 1990 Sep; 34(9):1780-2. Stratton CW, Gelfand MS, Gerberding JL, Chambers HF. PMID: 2285290.
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    124. Binding affinity for penicillin-binding protein 2a correlates with in vivo activity of beta-lactam antibiotics against methicillin-resistant Staphylococcus aureus. J Infect Dis. 1990 Sep; 162(3):705-10. Chambers HF, Sachdeva M, Kennedy S. PMID: 2387996.
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    125. Vancomycin for Staphylococcus aureus endocarditis in intravenous drug users. Antimicrob Agents Chemother. 1990 Jun; 34(6):1227-31. Small PM, Chambers HF. PMID: 2393284.
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    127. Effects of dosage, peak and trough concentrations in serum, protein binding, and bactericidal rate on efficacy of teicoplanin in a rabbit model of endocarditis. Antimicrob Agents Chemother. 1990 Apr; 34(4):510-4. Chambers HF, Kennedy S. PMID: 2140496.
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    128. Treatment of right-sided Staphylococcus aureus endocarditis in intravenous drug users with ciprofloxacin and rifampicin. Lancet. 1989 Nov 04; 2(8671):1071-3. Dworkin RJ, Lee BL, Sande MA, Chambers HF. PMID: 2572799.
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    129. Evaluation of cilofungin (LY121019) for treatment of experimental Candida albicans endocarditis in rabbits. Antimicrob Agents Chemother. 1989 Oct; 33(10):1822-3. Padula A, Chambers HF. PMID: 2686548.
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    130. Daptomycin (LY146032) for prevention and treatment of experimental aortic valve endocarditis in rabbits. Antimicrob Agents Chemother. 1989 Sep; 33(9):1522-5. Kennedy S, Chambers HF. PMID: 2554799.
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    134. Right-sided Staphylococcus aureus endocarditis in intravenous drug abusers: two-week combination therapy. Ann Intern Med. 1988 Oct 15; 109(8):619-24. Chambers HF, Miller RT, Newman MD. PMID: 3421575.
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    144. Failure of a once-daily regimen of cefonicid for treatment of endocarditis due to Staphylococcus aureus. Rev Infect Dis. 1984 Nov-Dec; 6 Suppl 4:S870-4. Chambers HF, Mills J, Drake TA, Sande MA. PMID: 6522927.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    145. Teicoplanin versus nafcillin and vancomycin in the treatment of experimental endocarditis caused by methicillin-susceptible or -resistant Staphylococcus aureus. Antimicrob Agents Chemother. 1984 Jul; 26(1):61-4. Chambers HF, Sande MA. PMID: 6236747.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    146. Endocarditis due to methicillin-resistant Staphylococcus aureus in rabbits: expression of resistance to beta-lactam antibiotics in vivo and in vitro. J Infect Dis. 1984 Jun; 149(6):894-903. Chambers HF, Hackbarth CJ, Drake TA, Rusnak MG, Sande MA. PMID: 6564133.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    147. Staphylococcus aureus endocarditis: clinical manifestations in addicts and nonaddicts. Medicine (Baltimore). 1983 May; 62(3):170-7. Chambers HF, Korzeniowski OM, Sande MA. PMID: 6843356.
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