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Binh Diep, PhD

TitleAssociate Professor
SchoolUCSF School of Medicine
DepartmentMedicine
Address1001 Potrero Ave
San Francisco CA 94110
Phone415-206-3355
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoc2008Microbial Pathogenesis
    University of California, BerkeleyPhD2005Infectious Diseases and Immunity
    University of California, BerkeleyB.A.2000Molecular Cell Biology
    Collapse Awards and Honors
    American Society for Microbiology2010ICAAC Young Investigator Award
    Pfizer2009ASPIRE Young Investigator Award

    Collapse Research 
    Collapse Research Activities and Funding
    Novel Mechanisms of Beta-lactam Resistance in Staph Aureus
    NIH/NIAID R56AI100291Aug 1, 2012 - Nov 30, 2012
    Role: Co-Principal Investigator
    Mechanisms of PVL-induced Acute Lung Injury
    NIH/NIAID R01AI087674Jun 15, 2010 - May 31, 2015
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Le VT, Le HN, Pinheiro MG, Hahn KJ, Dinh ML, Larson KB, Flanagan SD, Badiou C, Lina G, Tkaczyk C, Sellman BR, Diep B. Effects of tedizolid phosphate on survival outcomes and suppression of production of staphylococcal toxins in a rabbit model of MRSA necrotizing pneumonia. Antimicrob Agents Chemother. 2017 Jan 30. PMID: 28137816.
      View in: PubMed
    2. Diep B, Hillard JJ, Le VT, Tkaczyk C, Le HN, Tran VG, Rao RL, Dip EC, Pereira-Franchi EP, Cha P, Jacobson S, Broome R, Cheng LI, Weiss W, Prokai L, Nguyen V, Stover CK, Sellman BR. Targeting Alpha Toxin to Mitigate Its Lethal Toxicity in Ferret and Rabbit Models of Staphylococcus aureus Necrotizing Pneumonia. Antimicrob Agents Chemother. 2017 Jan 23. PMID: 28115346.
      View in: PubMed
    3. Hodille E, Cuerq C, Badiou C, Bienvenu F, Steghens JP, Cartier R, Bes M, Tristan A, Plesa A, Le VT, Diep B, Lina G, Dumitrescu O. Delta Hemolysin and Phenol-Soluble Modulins, but Not Alpha Hemolysin or Panton-Valentine Leukocidin, Induce Mast Cell Activation. Front Cell Infect Microbiol. 2016; 6:180. PMID: 28018862.
      View in: PubMed
    4. Le VT, Tkaczyk C, Chau S, Rao RL, Dip EC, Pereira-Franchi EP, Cheng L, Lee S, Koelkebeck H, Hilliard JJ, Yu XQ, Datta V, Nguyen V, Weiss W, Prokai L, O'Day T, Stover CK, Sellman BR, Diep B. Critical Role of Alpha-Toxin and Protective Effects of Its Neutralization by a Human Antibody in Acute Bacterial Skin and Skin Structure Infections. Antimicrob Agents Chemother. 2016 Oct; 60(10):5640-8. PMID: 27401576.
      View in: PubMed
    5. Diep B, Le VT, Visram ZC, Rouha H, Stulik L, Dip EC, Nagy G, Nagy E. Improved Protection in a Rabbit Model of Community-Associated Methicillin-Resistant Staphylococcus aureus Necrotizing Pneumonia upon Neutralization of Leukocidins in Addition to Alpha-Hemolysin. Antimicrob Agents Chemother. 2016 Oct; 60(10):6333-40. PMID: 27527081.
      View in: PubMed
    6. Diep B, Le VT, Badiou C, Le HN, Pinheiro MG, Duong AH, Wang X, Dip EC, Aguiar-Alves F, Basuino L, Marbach H, Mai TT, Sarda MN, Kajikawa O, Matute-Bello G, Tkaczyk C, Rasigade JP, Sellman BR, Chambers HF, Lina G. IVIG-mediated protection against necrotizing pneumonia caused by MRSA. Sci Transl Med. 2016 Sep 21; 8(357):357ra124. PMID: 27655850.
      View in: PubMed
    7. Cohen TS, Hilliard JJ, Jones-Nelson O, Keller AE, O'Day T, Tkaczyk C, DiGiandomenico A, Hamilton M, Pelletier M, Wang Q, Diep B, Le VT, Cheng L, Suzich J, Stover CK, Sellman BR. Staphylococcus aureus a toxin potentiates opportunistic bacterial lung infections. Sci Transl Med. 2016 Mar 9; 8(329):329ra31. PMID: 26962155.
      View in: PubMed
    8. Cheung GY, Yeh AJ, Kretschmer D, Duong AC, Tuffuor K, Fu CL, Joo HS, Diep B, Li M, Nakamura Y, Nunez G, Peschel A, Otto M. Functional characteristics of the Staphylococcus aureus d-toxin allelic variant G10S. Sci Rep. 2015; 5:18023. PMID: 26658455.
      View in: PubMed
    9. Chan LC, Basuino L, Diep B, Hamilton S, Chatterjee SS, Chambers HF. Ceftobiprole- and ceftaroline-resistant methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2015 May; 59(5):2960-3. PMID: 25753637; PMCID: PMC4394828.
    10. Jenkins A, Diep B, Mai TT, Vo NH, Warrener P, Suzich J, Stover CK, Sellman BR. Differential expression and roles of Staphylococcus aureus virulence determinants during colonization and disease. MBio. 2015; 6(1):e02272-14. PMID: 25691592; PMCID: PMC4337569.
    11. Date SV, Modrusan Z, Lawrence M, Morisaki JH, Toy K, Shah IM, Kim J, Park S, Xu M, Basuino L, Chan L, Zeitschel D, Chambers HF, Tan MW, Brown EJ, Diep B, Hazenbos WL. Global gene expression of methicillin-resistant Staphylococcus aureus USA300 during human and mouse infection. J Infect Dis. 2014 May 15; 209(10):1542-50. PMID: 24286981.
      View in: PubMed
    12. Diep B, Phung Q, Date S, Arnott D, Bakalarski C, Xu M, Nakamura G, Swem DL, Alexander MK, Le HN, Mai TT, Tan MW, Brown EJ, Nishiyama M. Identifying potential therapeutic targets of methicillin-resistant Staphylococcus aureus through in vivo proteomic analysis. J Infect Dis. 2014 May 15; 209(10):1533-41. PMID: 24280367; PMCID: PMC3997574.
    13. Hazenbos WL, Kajihara KK, Vandlen R, Morisaki JH, Lehar SM, Kwakkenbos MJ, Beaumont T, Bakker AQ, Phung Q, Swem LR, Ramakrishnan S, Kim J, Xu M, Shah IM, Diep B, Sai T, Sebrell A, Khalfin Y, Oh A, Koth C, Lin SJ, Lee BC, Strandh M, Koefoed K, Andersen PS, Spits H, Brown EJ, Tan MW, Mariathasan S. Novel staphylococcal glycosyltransferases SdgA and SdgB mediate immunogenicity and protection of virulence-associated cell wall proteins. PLoS Pathog. 2013; 9(10):e1003653. PMID: 24130480; PMCID: PMC3794999.
    14. Le VT, Diep B. Selected insights from application of whole-genome sequencing for outbreak investigations. Curr Opin Crit Care. 2013 Oct; 19(5):432-9. PMID: 23856896; PMCID: PMC4104273.
    15. Diep B, Gillet Y, Etienne J, Lina G, Vandenesch F. Panton-Valentine leucocidin and pneumonia. Lancet Infect Dis. 2013 Jul; 13(7):566. PMID: 23809217.
      View in: PubMed
    16. Rasigade JP, Trouillet-Assant S, Ferry T, Diep B, Sapin A, Lhoste Y, Ranfaing J, Badiou C, Benito Y, Bes M, Couzon F, Tigaud S, Lina G, Etienne J, Vandenesch F, Laurent F. PSMs of hypervirulent Staphylococcus aureus act as intracellular toxins that kill infected osteoblasts. PLoS One. 2013; 8(5):e63176. PMID: 23690994; PMCID: PMC3653922.
    17. Diep B, Afasizheva A, Le HN, Kajikawa O, Matute-Bello G, Tkaczyk C, Sellman B, Badiou C, Lina G, Chambers HF. Effects of linezolid on suppressing in vivo production of staphylococcal toxins and improving survival outcomes in a rabbit model of methicillin-resistant Staphylococcus aureus necrotizing pneumonia. J Infect Dis. 2013 Jul; 208(1):75-82. PMID: 23532096; PMCID: PMC3666136.
    18. Diep B. Use of whole-genome sequencing for outbreak investigations. Lancet Infect Dis. 2013 Feb; 13(2):99-101. PMID: 23158673.
      View in: PubMed
    19. Adams-Sapper S, Diep B, Perdreau-Remington F, Riley LW. Clonal composition and community clustering of drug-susceptible and -resistant Escherichia coli isolates from bloodstream infections. Antimicrob Agents Chemother. 2013 Jan; 57(1):490-7. PMID: 23147723; PMCID: PMC3535975.
    20. Tattevin P, Schwartz BS, Graber CJ, Volinski J, Bhukhen A, Bhukhen A, Mai TT, Vo NH, Dang DN, Phan TH, Basuino L, Perdreau-Remington F, Chambers HF, Diep B. Concurrent epidemics of skin and soft tissue infection and bloodstream infection due to community-associated methicillin-resistant Staphylococcus aureus. Clin Infect Dis. 2012 Sep; 55(6):781-8. PMID: 22670044; PMCID: PMC3657511.
    21. Diep B, Equils O, Huang DB, Gladue R. Linezolid effects on bacterial toxin production and host immune response: review of the evidence. Curr Ther Res Clin Exp. 2012 Jun; 73(3):86-102. PMID: 24648596; PMCID: PMC3954010.
    22. Li M, Du X, Villaruz AE, Diep B, Wang D, Song Y, Tian Y, Hu J, Yu F, Lu Y, Otto M. MRSA epidemic linked to a quickly spreading colonization and virulence determinant. Nat Med. 2012 May; 18(5):816-9. PMID: 22522561; PMCID: PMC3378817.
    23. Adams-Sapper S, Sergeevna-Selezneva J, Tartof S, Raphael E, Diep B, Perdreau-Remington F, Riley LW. Globally dispersed mobile drug-resistance genes in gram-negative bacterial isolates from patients with bloodstream infections in a US urban general hospital. J Med Microbiol. 2012 Jul; 61(Pt 7):968-74. PMID: 22493279; PMCID: PMC3542709.
    24. Perret M, Badiou C, Lina G, Burbaud S, Benito Y, Bes M, Cottin V, Couzon F, Juruj C, Dauwalder O, Goutagny N, Diep B, Vandenesch F, Henry T. Cross-talk between Staphylococcus aureus leukocidins-intoxicated macrophages and lung epithelial cells triggers chemokine secretion in an inflammasome-dependent manner. Cell Microbiol. 2012 Jul; 14(7):1019-36. PMID: 22329718.
      View in: PubMed
    25. Malachowa N, Whitney AR, Kobayashi SD, Sturdevant DE, Kennedy AD, Braughton KR, Shabb DW, Diep B, Chambers HF, Otto M, DeLeo FR. Global changes in Staphylococcus aureus gene expression in human blood. PLoS One. 2011; 6(4):e18617. PMID: 21525981; PMCID: PMC3078114.
    26. Diep B, Chan L, Tattevin P, Kajikawa O, Martin TR, Basuino L, Mai TT, Marbach H, Braughton KR, Whitney AR, Gardner DJ, Fan X, Tseng CW, Liu GY, Badiou C, Etienne J, Lina G, Matthay MA, DeLeo FR, Chambers HF. Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injury. Proc Natl Acad Sci U S A. 2010 Mar 23; 107(12):5587-92. PMID: 20231457; PMCID: PMC2851770.
    27. Graves SF, Kobayashi SD, Braughton KR, Diep B, Chambers HF, Otto M, Deleo FR. Relative contribution of Panton-Valentine leukocidin to PMN plasma membrane permeability and lysis caused by USA300 and USA400 culture supernatants. Microbes Infect. 2010 Jun; 12(6):446-56. PMID: 20172045; PMCID: PMC2883622.
    28. Mendes RE, Sader HS, Deshpande LM, Diep B, Chambers HF, Jones RN. Characterization of baseline methicillin-resistant Staphylococcus aureus isolates recovered from phase IV clinical trial for linezolid. J Clin Microbiol. 2010 Feb; 48(2):568-74. PMID: 19940054; PMCID: PMC2815625.
    29. Tattevin P, Basuino L, Bauer D, Diep B, Chambers HF. Ceftobiprole is superior to vancomycin, daptomycin, and linezolid for treatment of experimental endocarditis in rabbits caused by methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2010 Feb; 54(2):610-3. PMID: 19917746; PMCID: PMC2812130.
    30. Miragaia M, de Lencastre H, Perdreau-Remington F, Chambers HF, Higashi J, Sullam PM, Lin J, Wong KI, King KA, Otto M, Sensabaugh GF, Diep B. Genetic diversity of arginine catabolic mobile element in Staphylococcus epidermidis. PLoS One. 2009; 4(11):e7722. PMID: 19893740; PMCID: PMC2768820.
    31. Tseng CW, Kyme P, Low J, Rocha MA, Alsabeh R, Miller LG, Otto M, Arditi M, Diep B, Nizet V, Doherty TM, Beenhouwer DO, Liu GY. Staphylococcus aureus Panton-Valentine leukocidin contributes to inflammation and muscle tissue injury. PLoS One. 2009; 4(7):e6387. PMID: 19633710; PMCID: PMC2711303.
    32. Tattevin P, Diep B, Jula M, Perdreau-Remington F. Methicillin-resistant Staphylococcus aureus USA300 clone in long-term care facility. Emerg Infect Dis. 2009 Jun; 15(6):953-5. PMID: 19523301; PMCID: PMC2727319.
    33. Schwartz BS, Graber CJ, Diep B, Basuino L, Perdreau-Remington F, Chambers HF. Doxycycline, not minocycline, induces its own resistance in multidrug-resistant, community-associated methicillin-resistant Staphylococcus aureus clone USA300. Clin Infect Dis. 2009 May 15; 48(10):1483-4. PMID: 19374563.
      View in: PubMed
    34. Li M, Diep B, Villaruz AE, Braughton KR, Jiang X, DeLeo FR, Chambers HF, Lu Y, Otto M. Evolution of virulence in epidemic community-associated methicillin-resistant Staphylococcus aureus. Proc Natl Acad Sci U S A. 2009 Apr 7; 106(14):5883-8. PMID: 19293374; PMCID: PMC2667066.
    35. DeLeo FR, Diep B, Otto M. Host defense and pathogenesis in Staphylococcus aureus infections. Infect Dis Clin North Am. 2009 Mar; 23(1):17-34. PMID: 19135914; PMCID: PMC2748223.
    36. Chambers HF, Basuino L, Diep B, Steenbergen J, Zhang S, Tattevin P, Alder J. Relationship between susceptibility to daptomycin in vitro and activity in vivo in a rabbit model of aortic valve endocarditis. Antimicrob Agents Chemother. 2009 Apr; 53(4):1463-7. PMID: 19171803; PMCID: PMC2663086.
    37. Tattevin P, Diep B, Jula M, Perdreau-Remington F. Long-term follow-up of methicillin-resistant Staphylococcus aureus molecular epidemiology after emergence of clone USA300 in San Francisco jail populations. J Clin Microbiol. 2008 Dec; 46(12):4056-7. PMID: 18923004; PMCID: PMC2593251.
    38. Graber CJ, Jacobson MA, Perdreau-Remington F, Chambers HF, Diep B. Recurrence of skin and soft tissue infection caused by methicillin-resistant Staphylococcus aureus in a HIV primary care clinic. J Acquir Immune Defic Syndr. 2008 Oct 1; 49(2):231-3. PMID: 18820536.
      View in: PubMed
    39. Diep B, Palazzolo-Ballance AM, Tattevin P, Basuino L, Braughton KR, Whitney AR, Chen L, Kreiswirth BN, Otto M, DeLeo FR, Chambers HF. Contribution of Panton-Valentine leukocidin in community-associated methicillin-resistant Staphylococcus aureus pathogenesis. PLoS One. 2008; 3(9):e3198. PMID: 18787708; PMCID: PMC2527530.
    40. Diep B, Otto M. The role of virulence determinants in community-associated MRSA pathogenesis. Trends Microbiol. 2008 Aug; 16(8):361-9. PMID: 18585915; PMCID: PMC2778837.
    41. Diep B, Stone GG, Basuino L, Graber CJ, Miller A, des Etages SA, Jones A, Palazzolo-Ballance AM, Perdreau-Remington F, Sensabaugh GF, DeLeo FR, Chambers HF. The arginine catabolic mobile element and staphylococcal chromosomal cassette mec linkage: convergence of virulence and resistance in the USA300 clone of methicillin-resistant Staphylococcus aureus. J Infect Dis. 2008 Jun 1; 197(11):1523-30. PMID: 18700257.
      View in: PubMed
    42. Liu C, Graber CJ, Karr M, Diep B, Basuino L, Schwartz BS, Enright MC, O'Hanlon SJ, Thomas JC, Perdreau-Remington F, Gordon S, Gunthorpe H, Jacobs R, Jensen P, Leoung G, Rumack JS, Chambers HF. A population-based study of the incidence and molecular epidemiology of methicillin-resistant Staphylococcus aureus disease in San Francisco, 2004-2005. Clin Infect Dis. 2008 Jun 1; 46(11):1637-46. PMID: 18433335.
      View in: PubMed
    43. Miller LG, Diep B. Clinical practice: colonization, fomites, and virulence: rethinking the pathogenesis of community-associated methicillin-resistant Staphylococcus aureus infection. Clin Infect Dis. 2008 Mar 1; 46(5):752-60. PMID: 18220477.
      View in: PubMed
    44. Diep B, Chambers HF, Graber CJ, Szumowski JD, Miller LG, Han LL, Chen JH, Lin F, Lin J, Phan TH, Carleton HA, McDougal LK, Tenover FC, Cohen DE, Mayer KH, Sensabaugh GF, Perdreau-Remington F. Emergence of multidrug-resistant, community-associated, methicillin-resistant Staphylococcus aureus clone USA300 in men who have sex with men. Ann Intern Med. 2008 Feb 19; 148(4):249-57. PMID: 18283202.
      View in: PubMed
    45. Miller LG, Perdreau-Remington F, Bayer AS, Diep B, Tan N, Bharadwa K, Tsui J, Perlroth J, Shay A, Tagudar G, Ibebuogu U, Spellberg B. Clinical and epidemiologic characteristics cannot distinguish community-associated methicillin-resistant Staphylococcus aureus infection from methicillin-susceptible S. aureus infection: a prospective investigation. Clin Infect Dis. 2007 Feb 15; 44(4):471-82. PMID: 17243048.
      View in: PubMed
    46. Vivoni AM, Diep B, de Gouveia Magalhães AC, Santos KR, Riley LW, Sensabaugh GF, Moreira BM. Clonal composition of Staphylococcus aureus isolates at a Brazilian university hospital: identification of international circulating lineages. J Clin Microbiol. 2006 May; 44(5):1686-91. PMID: 16672394; PMCID: PMC1479203.
    47. Diep B, Carleton HA, Chang RF, Sensabaugh GF, Perdreau-Remington F. Roles of 34 virulence genes in the evolution of hospital- and community-associated strains of methicillin-resistant Staphylococcus aureus. J Infect Dis. 2006 Jun 1; 193(11):1495-503. PMID: 16652276.
      View in: PubMed
    48. Diep B, Gill SR, Chang RF, Phan TH, Chen JH, Davidson MG, Lin F, Lin J, Carleton HA, Mongodin EF, Sensabaugh GF, Perdreau-Remington F. Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus. Lancet. 2006 Mar 4; 367(9512):731-9. PMID: 16517273.
      View in: PubMed
    49. Pan ES, Diep B, Charlebois ED, Auerswald C, Carleton HA, Sensabaugh GF, Perdreau-Remington F. Population dynamics of nasal strains of methicillin-resistant Staphylococcus aureus--and their relation to community-associated disease activity. J Infect Dis. 2005 Sep 1; 192(5):811-8. PMID: 16088830.
      View in: PubMed
    50. Carleton HA, Diep B, Charlebois ED, Sensabaugh GF, Perdreau-Remington F. Community-adapted methicillin-resistant Staphylococcus aureus (MRSA): population dynamics of an expanding community reservoir of MRSA. J Infect Dis. 2004 Nov 15; 190(10):1730-8. PMID: 15499526.
      View in: PubMed
    51. Charlebois ED, Perdreau-Remington F, Kreiswirth B, Bangsberg DR, Ciccarone D, Diep B, Ng VL, Chansky K, Edlin BR, Edlin B, Chambers HF. Origins of community strains of methicillin-resistant Staphylococcus aureus. Clin Infect Dis. 2004 Jul 1; 39(1):47-54. PMID: 15206052; PMCID: PMC2567833.
    52. Lagally ET, Scherer JR, Blazej RG, Toriello NM, Diep B, Ramchandani M, Sensabaugh GF, Riley LW, Mathies RA. Integrated portable genetic analysis microsystem for pathogen/infectious disease detection. Anal Chem. 2004 Jun 1; 76(11):3162-70. PMID: 15167797.
      View in: PubMed
    53. Diep B, Sensabaugh GF, Somboonna N, Somboona NS, Carleton HA, Perdreau-Remington F. Widespread skin and soft-tissue infections due to two methicillin-resistant Staphylococcus aureus strains harboring the genes for Panton-Valentine leucocidin. J Clin Microbiol. 2004 May; 42(5):2080-4. PMID: 15131173; PMCID: PMC404676.
    54. Pan ES, Diep B, Carleton HA, Charlebois ED, Sensabaugh GF, Haller BL, Perdreau-Remington F. Increasing prevalence of methicillin-resistant Staphylococcus aureus infection in California jails. Clin Infect Dis. 2003 Nov 15; 37(10):1384-8. PMID: 14583874.
      View in: PubMed
    55. Diep B, Perdreau-Remington F, Sensabaugh GF. Clonal characterization of Staphylococcus aureus by multilocus restriction fragment typing, a rapid screening approach for molecular epidemiology. J Clin Microbiol. 2003 Oct; 41(10):4559-64. PMID: 14532182; PMCID: PMC254328.
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