Shibani Pati, MD, PhD

Title(s)Professor, Laboratory Medicine
SchoolSchool of Medicine
Address513 Parnassus Ave, HSE, #715
San Francisco CA 94143
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    Collapse Biography 
    Collapse Education and Training
    Princeton University, Princeton NJA.B.1992Molecular Biology
    University of Maryland School of Medicine, Baltimore, MDMD PhD2001Virology/Immunology
    Baylor College of Medicine and University of Texas Houston, Houston TXPostdoctoral Fellow2007Neurobiology

    Collapse Overview 
    Collapse Overview
    I am a translational vascular biologist with an interest in the role of endothelial dysfunction and vascular compromise in the pathogenesis of human disease. My specific areas of investigation involve the use of stem cell therapies and novel resuscitative modalities that can mitigate endothelial dysfunction and improve outcomes in traumatic injury. Areas of focus in the lab include traumatic brain injury (TBI), and hemorrhagic shock induced organ failure.

    Abnormalities in vascular permeability leading to inflammation, tissue edema, and end-organ dysfunction significantly contribute to the morbidity and mortality associated with a number of human disease processes. For example, although a number of factors contribute to the high mortality and morbidity associated with traumatic brain injury (TBI), the development of cerebral edema with brain swelling remains one of the most significant predictors of outcome. Similarly both hemorrhagic shock and septic shock are characterized by abnormal vascular permeability, which contributes to the development of shock-associated acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Despite the clear importance of abnormal vascular permeability in a number of human disease processes, there exists no therapeutic modality in current use to attenuate it. Our lab's focus is to understand the mechanisms of action that lead to organ failure in traumatic injury and to also discover novel therapies that improve outcomes. We are and have been part of number of pre-clinical and clinical trials investigating the therapeutic potential of stem cells, stem cell derived factors and novel blood products. This has led to exciting new avenues for the discovery of novel therapeutic agents that mitigate vascular injury.

    Collapse Research 
    Collapse Research Activities and Funding
    Advancing Development of Lyophilized Platelet Derived Extracellular Vesicles as a Hemostatic Agent for Hemorrhagic Shock and Polytrauma
    Department of Defense GRANT13693613Aug 31, 2023 - Aug 30, 2026
    Role: PI
    Description: The goal of this project is to study and advance the development of the novel blood product - Lyophilized Platelet Derived Extracellular Vesicles- for hemostasis in trauma, specifically polytrauma with TBI.
    Prehospital Kcentra for Trauma Patients with Hemorrhagic Shock
    Department of Defense PR210463Jan 2, 2023 - Jan 1, 2028
    Role: Co-Investigator
    Description: The goal of this clinical study is to evaluate the effects of 4 factor concentrate (Kcentra) for prehospital use in bleeding trauma patients. Our lab will study clinical samples to understand how Kcentra modulates the endotheliopathy of trauma pre-hospital.
    Attenuating the Endotheliopathy of Trauma in Multi-Domain Operations with Freeze Dried Platelets and Dried Plasma
    Department of Defense DM190136Sep 30, 2020 - Aug 29, 2023
    Role: PI
    Description: The goal of this project is to test the therapeutic potential of freeze dried platelet EVs in mediating hemostasis and also treating the endotheliopathy of trauma (EOT) to improve the prolonged field care or en route care of wounded warfighters
    The Therapeutic Potential of Cold Stored Platelets in Regulating Vascular Instability in Trauma
    NIH R01HL147880Aug 5, 2020 - Jun 30, 2024
    Role: Principal Investigator
    Freeze Dried Platelet Extracellular Vesicles as a Hemostatic Adjunct to Resuscitation for Prolonged Field Care
    Department of Defense DOD MRMC BA190168Apr 1, 2020 - Mar 31, 2022
    Role: PI
    Description: We will be carrying out studies to determine the potential of using platelet EVs and freeze dried EVs as a therapeutic and hemostatic agent in TBI models in mice.
    Targeting the Endotheliopathy of Trauma in Hemorrhagic Shock and Traumatic Brain Injury With Freeze-Dried Platelets
    DOD BA180248Sep 29, 2019 - Sep 28, 2023
    Role: PI
    Cellular Therapies and Novel Blood Products in Trauma and Critical Care Medicine: The Future of Transfusion Medicine
    NIH R13HL149316Sep 1, 2019 - Aug 31, 2020
    Role: Principal Investigator
    The Vasculo-protective and anti-inflammatory effects of Kcentra in Traumatic Brain Injury
    CSL BehringFeb 1, 2019 - Jan 31, 2021
    Role: PI
    Prothrombin Complex Concentrate for Prolonged Field Care of War Casualties
    Department of Defense DM160342Sep 30, 2017 - Sep 29, 2021
    Role: Co-Investigator
    Mesenchymal Stem Cells for Treatment of ARDS Following Trauma
    Department of Defense PR160568Sep 30, 2017 - Sep 29, 2021
    Role: Co-Investigator
    Mesenchymal Stem Cells for the prevention of Acute Respiratory Distress Syndrome after Pulmonary Contusion and Hemorrhagic Shock
    Department of Defense LogNo.BA150560Sep 30, 2016 - Sep 29, 2021
    Role: Co Investigator
    Modulation of Pulmonary Vascular Permeability and Inflammation by Mesenchymal Stem Cells (MSCs) in Hemorrhagic Shock
    NIH R01GM111899Sep 15, 2015 - Jul 31, 2021
    Role: Principal Investigator
    Systemic Effects of Bone Marrow-Derived MSCs on Vascular Stability
    NIH K18HL102256Sep 26, 2011 - Jul 31, 2013
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Immediate use cryoprecipitate products provide lasting organ protection in a rodent model of trauma/hemorrhagic shock and prolonged hypotensive resuscitation. J Trauma Acute Care Surg. 2023 10 01; 95(4):529-534. Zeineddin A, Wu F, Cao S, Corash L, Pati S, Kozar RA. PMID: 37314745.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    2. Early lyophilized cryoprecipitate enhances the ADAMTS13/VWF ratio to reduce systemic endotheliopathy and lessen lung injury in a mouse multiple-trauma hemorrhage model. J Trauma Acute Care Surg. 2023 08 01; 95(2S Suppl 1):S137-S143. Zeineddin A, Wu F, Dong JF, Vesselinov R, Neal MD, Corash L, Pati S, Kozar RA. PMID: 37211640; PMCID: PMC10389395.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    3. Histone deacetylase-6 modulates the effects of 4°C platelets on vascular endothelial permeability. Blood Adv. 2023 04 11; 7(7):1241-1257. Miyazawa B, Trivedi A, Vivona L, Lin M, Potter D, Nair A, Barry M, Cap AP, Pati S. PMID: 36375044; PMCID: PMC10090218.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    4. RECOVERY OF ENDOTHELIOPATHY AT 24 HOURS IN AN ESTABLISHED MOUSE MODEL OF HEMORRHAGIC SHOCK AND TRAUMA. Shock. 2022 10 01; 58(4):313-320. Barry M, Trivedi A, Vivona LR, Chui J, Pathipati P, Miyazawa B, Pati S. PMID: 36256627.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    5. Biomarkers of endothelial cell dysfunction persist beyond resuscitation in patients with hemorrhagic shock. J Trauma Acute Care Surg. 2022 11 01; 93(5):572-578. Zeineddin A, Wu F, Chao W, Zou L, Vesselinov R, Chipman AM, Dong JF, Huang H, Pati S, Kozar RA. PMID: 35939376; PMCID: PMC9613546.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    6. Lyophilized plasma resuscitation downregulates inflammatory gene expression in a mouse model of sepsis. J Trauma Acute Care Surg. 2022 08 01; 93(2S Suppl 1):S119-S127. Barry M, Wu F, Pati S, Chipman A, Geng H, Kozar R. PMID: 35881828.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    7. FFP maintains normal coagulation while Kcentra induces a hypercoagulable state in a porcine model of pulmonary contusion and hemorrhagic shock. J Trauma Acute Care Surg. 2022 07 01; 93(1):124-129. Dixon A, Beiling M, Smith S, Behrens B, Appleman L, Rick E, Murphy J, Madtson B, McCully B, Goodman A, Kanlerd A, Schaller T, Subramanian S, Trivedi A, Pati S, Schreiber M. PMID: 35261373.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    8. Mesenchymal stem cell extracellular vesicles mitigate vascular permeability and injury in the small intestine and lung in a mouse model of hemorrhagic shock and trauma. J Trauma Acute Care Surg. 2022 03 01; 92(3):489-498. Barry M, Trivedi A, Pathipati P, Miyazawa BY, Vivona LR, Togarrati PP, Khakoo M, Tanner H, Norris P, Pati S. PMID: 34882596; PMCID: PMC8866219.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    9. Treating the endotheliopathy of SARS-CoV-2 infection with plasma: Lessons learned from optimized trauma resuscitation with blood products. Transfusion. 2021 07; 61 Suppl 1:S336-S347. Pati S, Fennern E, Holcomb JB, Barry M, Trivedi A, Cap AP, Martin MJ, Wade C, Kozar R, Cardenas JC, Rappold JF, Spiegel R, Schreiber MA. PMID: 34269437; PMCID: PMC8446992.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    10. Cryoprecipitate attenuates the endotheliopathy of trauma in mice subjected to hemorrhagic shock and trauma. J Trauma Acute Care Surg. 2021 06 01; 90(6):1022-1031. Barry M, Trivedi A, Miyazawa BY, Vivona LR, Khakoo M, Zhang H, Pathipati P, Bagri A, Gatmaitan MG, Kozar R, Stein D, Pati S. PMID: 33797484; PMCID: PMC8141010.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    11. Evidence-Based and Clinically Relevant Outcomes for Hemorrhage Control Trauma Trials. Ann Surg. 2021 03 01; 273(3):395-401. Holcomb JB, Moore EE, Sperry JL, Jansen JO, Schreiber MA, Del Junco DJ, Spinella PC, Sauaia A, Brohi K, Bulger EM, Cap AP, Hess JR, Jenkins D, Lewis RJ, Neal MD, Newgard C, Pati S, Pusateri AE, Rizoli S, Russell RT, Shackelford SA, Stein DM, Steiner ME, Wang H, Ward KR, Young P. PMID: 33065652.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    12. Freeze-dried platelets promote clot formation, attenuate endothelial cell permeability, and decrease pulmonary vascular leak in a murine model of hemorrhagic shock. J Trauma Acute Care Surg. 2021 02 01; 90(2):203-214. Trivedi A, Potter DR, Miyazawa BY, Lin M, Vivona LR, Khakoo MA, Antebi B, Lee A, Ishler B, Dickerson M, Kozar R, Schreiber MA, Holcomb JB, Fitzpatrick GM, Pati S. PMID: 33060537.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    13. The effects of human prothrombin complex concentrate on hemorrhagic shock-induced lung injury in rats: Implications for testing human blood products in rodents. J Trauma Acute Care Surg. 2020 12; 89(6):1068-1075. Potter DR, Trivedi A, Lin M, Miyazawa BY, Vivona LR, McCully B, Nair A, Schreiber MA, Pati S. PMID: 32697449.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    14. Fresh frozen plasma attenuates lung injury in a novel model of prolonged hypotensive resuscitation. J Trauma Acute Care Surg. 2020 08; 89(2S Suppl 2):S118-S125. Chipman AM, Wu F, Pati S, Burdette AJ, Glaser JJ, Kozar RA. PMID: 32282752; PMCID: PMC7830779.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsPHPublic Health
    15. Resuscitative Strategies to Modulate the Endotheliopathy of Trauma: From Cell to Patient. Shock. 2020 05; 53(5):575-584. Wu F, Chipman A, Pati S, Miyasawa B, Corash L, Kozar RA. PMID: 31090680; PMCID: PMC6842415.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    16. Aggressive treatment of acute kidney injury and hyperkalemia improves survival in a combat relevant trauma model in swine. Am J Surg. 2020 05; 219(5):860-864. Smith S, Behrens B, McCully B, Murphy J, Bommiasamy A, Goodman A, Dewey E, Pati S, Schreiber M. PMID: 32245610.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    17. Is all plasma created equal? A pilot study of the effect of interdonor variability. J Trauma Acute Care Surg. 2020 01; 88(1):121-127. Chipman AM, Pati S, Potter D, Wu F, Lin M, Kozar RA. PMID: 31688783; PMCID: PMC7055504.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    18. Platelet-derived- Extracellular Vesicles Promote Hemostasis and Prevent the Development of Hemorrhagic Shock. Sci Rep. 2019 11 27; 9(1):17676. Lopez E, Srivastava AK, Burchfield J, Wang YW, Cardenas JC, Togarrati PP, Miyazawa B, Gonzalez E, Holcomb JB, Pati S, Wade CE. PMID: 31776369; PMCID: PMC6881357.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    19. Gaps in the knowledge of human platelet lysate as a cell culture supplement for cell therapy: a joint publication from the AABB and the International Society for Cell & Gene Therapy. Transfusion. 2019 11; 59(11):3448-3460. Bieback K, Fernandez-Muñoz B, Pati S, Schäfer R. PMID: 31412158.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    20. Regulation of endothelial cell permeability by platelet-derived extracellular vesicles. J Trauma Acute Care Surg. 2019 06; 86(6):931-942. Miyazawa B, Trivedi A, Togarrati PP, Potter D, Baimukanova G, Vivona L, Lin M, Lopez E, Callcut R, Srivastava AK, Kornblith LZ, Fields AT, Schreiber MA, Wade CE, Holcomb JB, Pati S. PMID: 31124890; PMCID: PMC7381393.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    21. Bone marrow donor selection and characterization of MSCs is critical for pre-clinical and clinical cell dose production. J Transl Med. 2019 04 17; 17(1):128. Trivedi A, Miyazawa B, Gibb S, Valanoski K, Vivona L, Lin M, Potter D, Stone M, Norris PJ, Murphy J, Smith S, Schreiber M, Pati S. PMID: 30995929; PMCID: PMC6469059.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    22. Regulation of Endothelial Cell Permeability by Platelet-Derived Extracellular Vesicles. J Trauma Acute Care Surg. 2019 Feb 13. Miyazawa B, Trivedi A, Togarrati PP, Potter D, Baimukanova G, Vivona L, Lin M, Lopez E, Callcut R, Srivastava AK, Kornblith LZ, Fields AT, Schreiber MA, Wade CE, Holcomb JB, Pati S. PMID: 30768560.
      View in: PubMed   Mentions:
    23. Introduction to the supplement on cellular therapies in trauma and critical care medicine. Transfusion. 2019 02; 59(S1):831-833. Pati S, Schreiber M, Rappold J. PMID: 30737819.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    24. Barriers to clinical research in trauma. Transfusion. 2019 02; 59(S1):846-853. Miskimins R, Pati S, Schreiber M. PMID: 30585332.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    25. Multipotent Adult Progenitor Cells, but Not Tissue Inhibitor of Matrix Metalloproteinase-3, Increase Tissue Sparing and Reduce Urological Complications following Spinal Cord Injury. J Neurotrauma. 2019 05 01; 36(9):1416-1427. Jones JM, DePaul MA, Gregory CR, Lang BT, Xie H, Zhu M, Rutten MJ, Mays RW, Busch SA, Pati S, Gregory KW. PMID: 30251917.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    26. A combat relevant model for the creation of acute lung injury in swine. J Trauma Acute Care Surg. 2018 07; 85(1S Suppl 2):S39-S43. Smith S, McCully B, Bommiasamy A, Murphy J, Behrens B, Pati S, Goodman A, Schreiber M. PMID: 29283971.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsPHPublic Health
    27. Elevated plasma levels of TIMP-3 are associated with a higher risk of acute respiratory distress syndrome and death following severe isolated traumatic brain injury. Trauma Surg Acute Care Open. 2018; 3(1):e000171. Hendrickson CM, Gibb SL, Miyazawa BY, Keating SM, Ross E, Conroy AS, Calfee CS, Pati S, Cohen MJ. PMID: 30023434; PMCID: PMC6045722.
      View in: PubMed   Mentions: 5  
    28. Platelet-Derived Microvesicles: A Potential Therapy for Trauma-Induced Coagulopathy. Shock. 2018 03; 49(3):243-248. Lopez E, Srivastava AK, Pati S, Holcomb JB, Wade CE. PMID: 28858139.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    29. Cellular therapies and stem cell applications in trauma. Am J Surg. 2018 05; 215(5):963-972. Wang Y, Pati S, Schreiber M. PMID: 29502858.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    30. Lyophilized plasma attenuates vascular permeability, inflammation and lung injury in hemorrhagic shock. PLoS One. 2018; 13(2):e0192363. Pati S, Peng Z, Wataha K, Miyazawa B, Potter DR, Kozar RA. PMID: 29394283; PMCID: PMC5796727.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    31. Mesenchymal stem cell-derived extracellular vesicles attenuate pulmonary vascular permeability and lung injury induced by hemorrhagic shock and trauma. J Trauma Acute Care Surg. 2018 02; 84(2):245-256. Potter DR, Miyazawa BY, Gibb SL, Deng X, Togaratti PP, Croze RH, Srivastava AK, Trivedi A, Matthay M, Holcomb JB, Schreiber MA, Pati S. PMID: 29251710; PMCID: PMC6378956.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    32. Plasma Resuscitation Improved Survival in a Cecal Ligation and Puncture Rat Model of Sepsis. Shock. 2018 Jan; 49(1):53-61. Chang R, Holcomb JB, Johansson PI, Pati S, Schreiber MA, Wade CE. PMID: 28591008; PMCID: PMC5718978.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    33. Cellular therapies in trauma and critical care medicine: Looking towards the future. PLoS Med. 2017 Jul; 14(7):e1002343. Pati S, Rasmussen TE. PMID: 28700606; PMCID: PMC5507410.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    34. Resuscitation of Hypotensive Traumatic Brain Injured Animals With Spray-Dried Plasma Does Not Adversely Alter Physiology and Improves Blood-Brain Barrier Function. Mil Med. 2017 07; 182(7):e1706-e1711. McDaniel S, Golla S, Moore AN, DaCorta J, Bode A, Pati S, Dash PK, Zhao J. PMID: 28810961.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    35. Serum from dengue virus-infected patients with and without plasma leakage differentially affects endothelial cells barrier function in vitro. PLoS One. 2017; 12(6):e0178820. Tramontini Gomes de Sousa Cardozo F, Baimukanova G, Lanteri MC, Keating SM, Moraes Ferreira F, Heitman J, Pannuti CS, Pati S, Romano CM, Cerdeira Sabino E. PMID: 28586397; PMCID: PMC5460851.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    36. Concise Review: Mesenchymal Stem (Stromal) Cells: Biology and Preclinical Evidence for Therapeutic Potential for Organ Dysfunction Following Trauma or Sepsis. Stem Cells. 2017 02; 35(2):316-324. Matthay MA, Pati S, Lee JW. PMID: 27888550.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    37. Plasma Transfusion: History, Current Realities, and Novel Improvements. Shock. 2016 11; 46(5):468-479. Watson JJ, Pati S, Schreiber MA. PMID: 27380536.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    38. Lack of species-specific difference in pulmonary function when using mouse versus human plasma in a mouse model of hemorrhagic shock. J Trauma Acute Care Surg. 2016 11; 81(5 Suppl 2 Proceedings of the 2015 Military Health System Research Symposium):S171-S176. Peng Z, Pati S, Fontaine MJ, Hall K, Herrera AV, Kozar RA. PMID: 27768665; PMCID: PMC5267480.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    39. Wnt3a, a Protein Secreted by Mesenchymal Stem Cells Is Neuroprotective and Promotes Neurocognitive Recovery Following Traumatic Brain Injury. Stem Cells. 2016 05; 34(5):1263-72. Zhao Y, Gibb SL, Zhao J, Moore AN, Hylin MJ, Menge T, Xue H, Baimukanova G, Potter D, Johnson EM, Holcomb JB, Cox CS, Dash PK, Pati S. PMID: 26840479.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    40. Dried plasma: state of the science and recent developments. Transfusion. 2016 04; 56 Suppl 2:S128-39. Pusateri AE, Given MB, Schreiber MA, Spinella PC, Pati S, Kozar RA, Khan A, Dacorta JA, Kupferer KR, Prat N, Pidcoke HF, Macdonald VW, Malloy WW, Sailliol A, Cap AP. PMID: 27100749.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansPHPublic Health
    41. Modulating the endotheliopathy of trauma: Factor concentrate versus fresh frozen plasma. J Trauma Acute Care Surg. 2016 Apr; 80(4):576-84; discussion 584-5. Pati S, Potter DR, Baimukanova G, Farrel DH, Holcomb JB, Schreiber MA. PMID: 26808040.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    42. The effects of 22°C and 4°C storage of platelets on vascular endothelial integrity and function. Transfusion. 2016 Mar; 56 Suppl 1:S52-64. Baimukanova G, Miyazawa B, Potter DR, Gibb SL, Keating S, Danesh A, Beyer A, Dayter Y, Bruhn R, Muench MO, Cap AP, Norris PJ, Spinella P, Cohen M, Pati S. PMID: 27001362.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    43. Platelets regulate vascular endothelial stability: assessing the storage lesion and donor variability of apheresis platelets. Transfusion. 2016 Mar; 56 Suppl 1:S65-75. Baimukanova G, Miyazawa B, Potter DR, Muench MO, Bruhn R, Gibb SL, Spinella PC, Cap AP, Cohen MJ, Pati S. PMID: 27001364; PMCID: PMC5098902.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    44. Cellular Therapies in Trauma and Critical Care Medicine: Forging New Frontiers. Shock. 2015 Dec; 44(6):505-23. Pati S, Pilia M, Grimsley JM, Karanikas AT, Oyeniyi B, Holcomb JB, Cap AP, Rasmussen TE. PMID: 26428845; PMCID: PMC4851225.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    45. Plasma-Mediated Gut Protection After Hemorrhagic Shock is Lessened in Syndecan-1-/- Mice. Shock. 2015 Nov; 44(5):452-7. Ban K, Peng Z, Pati S, Witkov RB, Park PW, Kozar RA. PMID: 26263434; PMCID: PMC4816460.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    46. TIMP3 Attenuates the Loss of Neural Stem Cells, Mature Neurons and Neurocognitive Dysfunction in Traumatic Brain Injury. Stem Cells. 2015 Dec; 33(12):3530-44. Gibb SL, Zhao Y, Potter D, Hylin MJ, Bruhn R, Baimukanova G, Zhao J, Xue H, Abdel-Mohsen M, Pillai SK, Moore AN, Johnson EM, Cox CS, Dash PK, Pati S. PMID: 26299440.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    47. Syndecan-1 restitution by plasma after hemorrhagic shock. J Trauma Acute Care Surg. 2015 Jun; 78(6 Suppl 1):S83-6. Kozar RA, Pati S. PMID: 26002270; PMCID: PMC4841450.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    48. Fresh frozen plasma and spray-dried plasma mitigate pulmonary vascular permeability and inflammation in hemorrhagic shock. J Trauma Acute Care Surg. 2015 Jun; 78(6 Suppl 1):S7-S17. Potter DR, Baimukanova G, Keating SM, Deng X, Chu JA, Gibb SL, Peng Z, Muench MO, Fomin ME, Spinella PC, Kozar R, Pati S. PMID: 26002267.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    49. Endothelial glycocalyx shedding and vascular permeability in severely injured trauma patients. J Transl Med. 2015 Apr 12; 13:117. Rahbar E, Cardenas JC, Baimukanova G, Usadi B, Bruhn R, Pati S, Ostrowski SR, Johansson PI, Holcomb JB, Wade CE. PMID: 25889764; PMCID: PMC4397670.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansCells
    50. The whole is greater than the sum of its parts: hemostatic profiles of whole blood variants. J Trauma Acute Care Surg. 2014 Dec; 77(6):818-27. Kornblith LZ, Howard BM, Cheung CK, Dayter Y, Pandey S, Busch MP, Pati S, Callcut RA, Vilardi RF, Redick BJ, Nelson MF, Cohen MJ. PMID: 25051379.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    51. Never-frozen liquid plasma blocks endothelial permeability as effectively as thawed fresh frozen plasma. J Trauma Acute Care Surg. 2014 Jul; 77(1):28-33; discussion 33. Cao Y, Dua A, Matijevic N, Wang YW, Pati S, Wade CE, Ko TC, Holcomb JB. PMID: 24977751.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    52. Trauma hemostasis and oxygenation research position paper on remote damage control resuscitation: definitions, current practice, and knowledge gaps. Shock. 2014 May; 41 Suppl 1:3-12. Jenkins DH, Rappold JF, Badloe JF, Berséus O, Blackbourne L, Brohi KH, Butler FK, Cap AP, Cohen MJ, Davenport R, DePasquale M, Doughty H, Glassberg E, Hervig T, Hooper TJ, Kozar R, Maegele M, Moore EE, Murdock A, Ness PM, Pati S, Rasmussen T, Sailliol A, Schreiber MA, Sunde GA, van de Watering LM, Ward KR, Weiskopf RB, White NJ, Strandenes G, Spinella PC. PMID: 24430539; PMCID: PMC4309265.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
    53. Fresh frozen plasma lessens pulmonary endothelial inflammation and hyperpermeability after hemorrhagic shock and is associated with loss of syndecan 1. Shock. 2013 Sep; 40(3):195-202. Peng Z, Pati S, Potter D, Brown R, Holcomb JB, Grill R, Wataha K, Park PW, Xue H, Kozar RA. PMID: 23807246; PMCID: PMC3764452.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    54. Autologous bone marrow mononuclear cells therapy attenuates activated microglial/macrophage response and improves spatial learning after traumatic brain injury. J Trauma Acute Care Surg. 2013 Sep; 75(3):410-6. Bedi SS, Walker PA, Shah SK, Jimenez F, Thomas CP, Smith P, Hetz RA, Xue H, Pati S, Dash PK, Cox CS. PMID: 23928737; PMCID: PMC4086922.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    55. Coronary microvascular pericytes are the cellular target of sunitinib malate-induced cardiotoxicity. Sci Transl Med. 2013 May 29; 5(187):187ra69. Chintalgattu V, Rees ML, Culver JC, Goel A, Jiffar T, Zhang J, Dunner K, Pati S, Bankson JA, Pasqualini R, Arap W, Bryan NS, Taegtmeyer H, Langley RR, Yao H, Kupferman ME, Entman ML, Dickinson ME, Khakoo AY. PMID: 23720580; PMCID: PMC3833098.
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    56. Spray-dried plasma and fresh frozen plasma modulate permeability and inflammation in vitro in vascular endothelial cells. Transfusion. 2013 Jan; 53 Suppl 1:80S-90S. Wataha K, Menge T, Deng X, Shah A, Bode A, Holcomb JB, Potter D, Kozar R, Spinella PC, Pati S. PMID: 23301978.
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    57. Optimal trauma resuscitation with plasma as the primary resuscitative fluid: the surgeon's perspective. Hematology Am Soc Hematol Educ Program. 2013; 2013:656-9. Holcomb JB, Pati S. PMID: 24319247.
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    58. Mesenchymal stem cells regulate blood-brain barrier integrity through TIMP3 release after traumatic brain injury. Sci Transl Med. 2012 Nov 21; 4(161):161ra150. Menge T, Zhao Y, Zhao J, Wataha K, Gerber M, Zhang J, Letourneau P, Redell J, Shen L, Wang J, Peng Z, Xue H, Kozar R, Cox CS, Khakoo AY, Holcomb JB, Dash PK, Pati S. PMID: 23175708; PMCID: PMC3890105.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    59. Human mesenchymal stem cells inhibit endothelial proliferation and angiogenesis via cell-cell contact through modulation of the VE-Cadherin/β-catenin signaling pathway. Stem Cells Dev. 2013 Jan 01; 22(1):148-57. Menge T, Gerber M, Wataha K, Reid W, Guha S, Cox CS, Dash P, Reitz MS, Khakoo AY, Pati S. PMID: 22734943; PMCID: PMC3528090.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    60. Caffeic Acid phenethyl ester protects blood-brain barrier integrity and reduces contusion volume in rodent models of traumatic brain injury. J Neurotrauma. 2012 Apr 10; 29(6):1209-18. Zhao J, Pati S, Redell JB, Zhang M, Moore AN, Dash PK. PMID: 22150135; PMCID: PMC3325550.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    61. Aged plasma transfusion increases mortality in a rat model of uncontrolled hemorrhage. J Trauma. 2011 Nov; 71(5):1115-9. Letourneau PA, McManus M, Sowards K, Wang W, Wang YW, Matijevic N, Pati S, Wade CE, Holcomb JB. PMID: 22071917; PMCID: PMC3217202.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    62. Bone marrow derived mesenchymal stem cells inhibit inflammation and preserve vascular endothelial integrity in the lungs after hemorrhagic shock. PLoS One. 2011; 6(9):e25171. Pati S, Gerber MH, Menge TD, Wataha KA, Zhao Y, Baumgartner JA, Zhao J, Letourneau PA, Huby MP, Baer LA, Salsbury JR, Kozar RA, Wade CE, Walker PA, Dash PK, Cox CS, Doursout MF, Holcomb JB. PMID: 21980392; PMCID: PMC3182198.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    63. Involvement of the glycogen synthase kinase-3 signaling pathway in TBI pathology and neurocognitive outcome. PLoS One. 2011; 6(9):e24648. Dash PK, Johnson D, Clark J, Orsi SA, Zhang M, Zhao J, Grill RJ, Moore AN, Pati S. PMID: 21935433; PMCID: PMC3174188.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    64. Modulation of syndecan-1 shedding after hemorrhagic shock and resuscitation. PLoS One. 2011; 6(8):e23530. Haywood-Watson RJ, Holcomb JB, Gonzalez EA, Peng Z, Pati S, Park PW, Wang W, Zaske AM, Menge T, Kozar RA. PMID: 21886795; PMCID: PMC3158765.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansCells
    65. Increased platelet:RBC ratios are associated with improved survival after massive transfusion. J Trauma. 2011 Aug; 71(2 Suppl 3):S318-28. Holcomb JB, Zarzabal LA, Michalek JE, Kozar RA, Spinella PC, Perkins JG, Matijevic N, Dong JF, Pati S, Wade CE, Trauma Outcomes Group, Holcomb JB, Wade CE, Cotton BA, Kozar RA, Brasel KJ, Vercruysse GA, MacLeod JB, Dutton RP, Hess JR, Duchesne JC, McSwain NE, Muskat PC, Johannigamn JA, Cryer HM, Tillou A, Cohen MJ, Pittet JF, Knudson P, DeMoya MA, Schreiber MA, Tieu BH, Brundage SI, Napolitano LM, Brunsvold ME, Sihler KC, Beilman GJ, Peitzman AB, Zenati MS, Sperry JL, Alarcon LH, Croce MA, Minei JP, Steward RM, Cohn SM, Michalek JE, Bulger EM, Nunez TC, Ivatury RR, Meredith JW, Miller PR, Pomper GJ, Marin B. PMID: 21814099.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    66. Increased transforming growth factor β contributes to deterioration of refrigerated fresh frozen plasma's effects in vitro on endothelial cells. Shock. 2011 Jul; 36(1):54-9. Duan C, Cao Y, Deng X, Wang W, Yang W, Liu X, Chen Z, Pati S, Kozar RA, Gonzalez EA, Wade CE, Holcomb JB, Ko TC. PMID: 21330944; PMCID: PMC3763495.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    67. Plasma restoration of endothelial glycocalyx in a rodent model of hemorrhagic shock. Anesth Analg. 2011 Jun; 112(6):1289-95. Kozar RA, Peng Z, Zhang R, Holcomb JB, Pati S, Park P, Ko TC, Paredes A. PMID: 21346161; PMCID: PMC3102787.
      View in: PubMed   Mentions: 132     Fields:    Translation:AnimalsCells
    68. Human Bone Marrow Derived Mesenchymal Stem Cells Regulate Leukocyte-Endothelial Interactions and Activation of Transcription Factor NF-Kappa B. J Tissue Sci Eng. 2011; Suppl 3:001. Letourneau PA, Menge TD, Wataha KA, Wade CE, S Cox C, Holcomb JB, Pati S. PMID: 25309818; PMCID: PMC4189804.
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    69. Human mesenchymal stem cells inhibit vascular permeability by modulating vascular endothelial cadherin/β-catenin signaling. Stem Cells Dev. 2011 Jan; 20(1):89-101. Pati S, Khakoo AY, Zhao J, Jimenez F, Gerber MH, Harting M, Redell JB, Grill R, Matsuo Y, Guha S, Cox CS, Reitz MS, Holcomb JB, Dash PK. PMID: 20446815; PMCID: PMC3128758.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    70. Mesenchymal stem cells stimulate protective genetic reprogramming of injured cardiac ventricular myocytes. J Mol Cell Cardiol. 2011 Feb; 50(2):346-56. Rogers TB, Pati S, Gaa S, Riley D, Khakoo AY, Patel S, Wardlow RD, Frederick CA, Hall G, He LP, Lederer WJ. PMID: 20837021.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    71. Intravenous multipotent adult progenitor cell therapy for traumatic brain injury: preserving the blood brain barrier via an interaction with splenocytes. Exp Neurol. 2010 Oct; 225(2):341-52. Walker PA, Shah SK, Jimenez F, Gerber MH, Xue H, Cutrone R, Hamilton JA, Mays RW, Deans R, Pati S, Dash PK, Cox CS. PMID: 20637752; PMCID: PMC3774549.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    72. Protective effects of fresh frozen plasma on vascular endothelial permeability, coagulation, and resuscitation after hemorrhagic shock are time dependent and diminish between days 0 and 5 after thaw. J Trauma. 2010 Jul; 69 Suppl 1:S55-63. Pati S, Matijevic N, Doursout MF, Ko T, Cao Y, Deng X, Kozar RA, Hartwell E, Conyers J, Holcomb JB. PMID: 20622621; PMCID: PMC3126659.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    73. Valproate administered after traumatic brain injury provides neuroprotection and improves cognitive function in rats. PLoS One. 2010 Jun 30; 5(6):e11383. Dash PK, Orsi SA, Zhang M, Grill RJ, Pati S, Zhao J, Moore AN. PMID: 20614021; PMCID: PMC2894851.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    74. Direct intrathecal implantation of mesenchymal stromal cells leads to enhanced neuroprotection via an NFkappaB-mediated increase in interleukin-6 production. Stem Cells Dev. 2010 Jun; 19(6):867-76. Walker PA, Harting MT, Jimenez F, Shah SK, Pati S, Dash PK, Cox CS. PMID: 19775197; PMCID: PMC2891441.
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    75. Fresh frozen plasma increases adhesion molecule expression on human pulmonary endothelial cells. J Surg Res. 2010 Oct; 163(2):317-22. Letourneau PA, Pati S, Gerber MH, Jimenez F, Holcomb JB. PMID: 20599210; PMCID: PMC2943032.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    76. Cardiomyocyte PDGFR-beta signaling is an essential component of the mouse cardiac response to load-induced stress. J Clin Invest. 2010 Feb; 120(2):472-84. Chintalgattu V, Ai D, Langley RR, Zhang J, Bankson JA, Shih TL, Reddy AK, Coombes KR, Daher IN, Pati S, Patel SS, Pocius JS, Taffet GE, Buja LM, Entman ML, Khakoo AY. PMID: 20071776; PMCID: PMC2810076.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    77. Intra-hippocampal administration of the VEGF receptor blocker PTK787/ZK222584 impairs long-term memory. Brain Res. 2009 Feb 23; 1256:85-91. Pati S, Orsi SA, Moore AN, Dash PK. PMID: 19100245; PMCID: PMC2692845.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    78. HIV-1 transgenic rat CD4+ T cells develop decreased CD28 responsiveness and suboptimal Lck tyrosine dephosphorylation following activation. Virology. 2006 Sep 30; 353(2):357-65. Yadav A, Pati S, Nyugen A, Barabitskaja O, Mondal P, Anderson M, Gallo RC, Huso DL, Reid W. PMID: 16828835.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    79. Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma. J Exp Med. 2006 May 15; 203(5):1235-47. Khakoo AY, Pati S, Anderson SA, Reid W, Elshal MF, Rovira II, Nguyen AT, Malide D, Combs CA, Hall G, Zhang J, Raffeld M, Rogers TB, Stetler-Stevenson W, Frank JA, Reitz M, Finkel T. PMID: 16636132; PMCID: PMC2121206.
      View in: PubMed   Mentions: 321     Fields:    Translation:AnimalsCells
    80. Suppression of MIP-1beta transcription in human T cells is regulated by inducible cAMP early repressor (ICER). J Leukoc Biol. 2006 Feb; 79(2):378-87. Barabitskaja O, Foulke JS, Pati S, Bodor J, Reitz MS. PMID: 16443828.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    81. Tumorigenesis by human herpesvirus 8 vGPCR is accelerated by human immunodeficiency virus type 1 Tat. J Virol. 2004 Sep; 78(17):9336-42. Guo HG, Pati S, Sadowska M, Charurat M, Reitz M. PMID: 15308728; PMCID: PMC506953.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    82. Human herpesvirus 8-encoded vGPCR activates nuclear factor of activated T cells and collaborates with human immunodeficiency virus type 1 Tat. J Virol. 2003 May; 77(10):5759-73. Pati S, Foulke JS, Barabitskaya O, Kim J, Nair BC, Hone D, Smart J, Feldman RA, Reitz M. PMID: 12719569; PMCID: PMC154031.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    83. Antitumorigenic effects of HIV protease inhibitor ritonavir: inhibition of Kaposi sarcoma. Blood. 2002 May 15; 99(10):3771-9. Pati S, Pelser CB, Dufraine J, Bryant JL, Reitz MS, Weichold FF. PMID: 11986235.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    84. Activation of NF-kappaB by the human herpesvirus 8 chemokine receptor ORF74: evidence for a paracrine model of Kaposi's sarcoma pathogenesis. J Virol. 2001 Sep; 75(18):8660-73. Pati S, Cavrois M, Guo HG, Foulke JS, Kim J, Feldman RA, Reitz M. PMID: 11507211; PMCID: PMC115111.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansCells
    85. Human herpesvirus 8 K1-associated nuclear factor-kappa B-dependent promoter activity: role in Kaposi's sarcoma inflammation? J Natl Cancer Inst Monogr. 2001; (28):15-23. Samaniego F, Pati S, Karp JE, Prakash O, Bose D. PMID: 11158202.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    86. Urinary proteins with pro-apoptotic and antitumor activity. Apoptosis. 2000 Feb; 5(1):21-8. Pati S, Lee Y, Samaniego F. PMID: 11227487.
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    87. HIV-1 protease inhibitor ritonavir modulates susceptibility to apoptosis of uninfected T cells. J Hum Virol. 1999 Sep-Oct; 2(5):261-9. Weichold FF, Bryant JL, Pati S, Barabitskaya O, Gallo RC, Reitz MS. PMID: 10551732.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    88. Gain of function mutations in p53. Nat Genet. 1993 May; 4(1):42-6. Dittmer D, Pati S, Zambetti G, Chu S, Teresky AK, Moore M, Finlay C, Levine AJ. PMID: 8099841.
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