Shibani Pati, MD, PhD

Title(s)Associate Professor, Laboratory Medicine
SchoolSchool of Medicine
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    Princeton University, Princeton NJA.B.1992Molecular Biology
    University of Maryland School of Medicine, Baltimore, MDMD PhD2001Virology/Immunology
    Baylor College of Medicine and University of Texas Houston, Houston TXPostdoctoral Fellow2007Neurobiology

    Collapse Overview 
    Collapse Overview
    I am a vascular biologist with an interest in the role of endothelial dysfunction and vascular compromise in the pathogenesis of human disease. My specific areas of investigation involve the use of stem cell therapies and novel resuscitative modalities that can mitigate endothelial dysfunction and improve outcomes in traumatic injury. Areas of focus in the lab include traumatic brain injury (TBI), spinal cord injury (SCI), and hemorrhagic shock induced organ failure.

    Abnormalities in vascular permeability leading to inflammation, tissue edema, and end-organ dysfunction significantly contribute to the morbidity and mortality associated with a number of human disease processes. For example, although a number of factors contribute to the high mortality and morbidity associated with traumatic brain injury (TBI), the development of cerebral edema with brain swelling remains one of the most significant predictors of outcome. Similarly both hemorrhagic shock and septic shock are characterized by abnormal vascular permeability, which contributes to the development of shock-associated acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Despite the clear importance of abnormal vascular permeability in a number of human disease processes, there exists no therapeutic modality in current use to attenuate it. Our lab's focus is to understand the mechanisms of action that lead to organ failure in traumatic injury and to also discover novel therapies that improve outcomes.

    Collapse Research 
    Collapse Research Activities and Funding
    The Vasculo-protective and anti-inflammatory effects of Kcentra
    CSL BehringFeb 1, 2019 - Jan 31, 2021
    Role: PI
    Mesenchymal Stem Cells for Treatment of ARDS Following Trauma
    Department of Defense PR160568Sep 30, 2017 - Sep 29, 2021
    Role: Co-Investigator
    Prothrombin Complex Concentrate for Prolonged Field Care of War Casualties
    Department of Defense DM160342Sep 30, 2017 - Sep 29, 2020
    Role: Co-Investigator
    Dried Plasma to Improve Outcomes in Polytrauma, Hemorrhage and Trauma Associated Sepsis (TAS): Novel Solutions for the Prolonged Field Care Environment
    Department of Defense DM160146Sep 30, 2017 - Sep 29, 2019
    Role: Co-Investigator
    Platelets Modulate Vascular Stability: Assessing the Biological Properties and Function of Apheresis Platelets Stored at 22o C vs. 4o C
    Department of Defense DOD W81XWH-16-2-0035 (Log#BA150440).Sep 30, 2016 - Sep 29, 2019
    Role: PI
    Mesenchymal Stem Cells for the prevention of Acute Respiratory Distress Syndrome after Pulmonary Contusion and Hemorrhagic Shock
    Department of Defense LogNo.BA150560Sep 30, 2016 - Sep 29, 2019
    Role: Co Investigator
    Modulation of Pulmonary Vascular Permeability and Inflammation by Mesenchymal Stem Cells (MSCs) in Hemorrhagic Shock
    NIH/NIGMS R01GM111899Sep 15, 2015 - Jul 31, 2020
    Role: Principal Investigator
    Systemic Effects of Bone Marrow-Derived MSCs on Vascular Stability
    NIH/NHLBI K18HL102256Sep 26, 2011 - Jul 31, 2013
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Jones JM, DePaul MA, Gregory CR, Lang BT, Xie H, Zhu M, Rutten MJ, Mays RW, Busch SA, Pati S, Gregory KW. Multi-Potent Adult Progenitor Cells, but not Tissue Inhibitor of Matrix Metalloproteinase-3, Increase Tissue Sparing and Reduce Urological Complications following Spinal Cord Injury. J Neurotrauma. 2018 Nov 02. PMID: 30251917.
      View in: PubMed
    2. Hendrickson CM, Gibb SL, Miyazawa BY, Keating SM, Ross E, Conroy AS, Calfee CS, Pati S, Cohen MJ. Elevated plasma levels of TIMP-3 are associated with a higher risk of acute respiratory distress syndrome and death following severe isolated traumatic brain injury. Trauma Surg Acute Care Open. 2018; 3(1):e000171. PMID: 30023434.
      View in: PubMed
    3. Zhao J, Pati S, Redell JB, Zhang M, Moore AN, Dash PK. Caffeic Acid phenethyl ester protects blood-brain barrier integrity and reduces contusion volume in rodent models of traumatic brain injury. J Neurotrauma. 2012 Apr 10; 29(6):1209-18. PMID: 22150135; PMCID: PMC3325550.
    4. Dittmer D, Pati S, Zambetti G, Chu S, Teresky AK, Moore M, Finlay C, Levine AJ. Gain of function mutations in p53. Nat Genet. 1993 May; 4(1):42-6. PMID: 8099841.
      View in: PubMed