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Long-term wireless streaming of neural recordings for circuit discovery and adaptive stimulation in individuals with Parkinson's disease. Nat Biotechnol. 2021 May 03.
Gilron R, Little S, Perrone R, Wilt R, de Hemptinne C, Yaroshinsky MS, Racine CA, Wang SS, Ostrem JL, Larson PS, Wang DD, Galifianakis NB, Bledsoe IO, San Luciano M, Dawes HE, Worrell GA, Kremen V, Borton DA, Denison T, Starr PA. PMID: 33941932.
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Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies. Front Hum Neurosci. 2021; 15:644593.
Vedam-Mai V, Deisseroth K, Giordano J, Lazaro-Munoz G, Chiong W, Suthana N, Langevin JP, Gill J, Goodman W, Provenza NR, Halpern CH, Shivacharan RS, Cunningham TN, Sheth SA, Pouratian N, Scangos KW, Mayberg HS, Horn A, Johnson KA, Butson CR, Gilron R, de Hemptinne C, Wilt R, Yaroshinsky M, Little S, Starr P, Worrell G, Shirvalkar P, Chang E, Volkmann J, Muthuraman M, Groppa S, Kühn AA, Li L, Johnson M, Otto KJ, Raike R, Goetz S, Wu C, Silburn P, Cheeran B, Pathak YJ, Malekmohammadi M, Gunduz A, Wong JK, Cernera S, Wagle Shukla A, Ramirez-Zamora A, Deeb W, Patterson A, Foote KD, Okun MS. PMID: 33953663.
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The Neurophysiology of Sleep in Parkinson's Disease. Mov Disord. 2021 Apr 07.
Zahed H, Zuzuarregui JRP, Gilron R, Denison T, Starr PA, Little S. PMID: 33826171.
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A space-time continuum in DBS: structural and functional advances in Parkinson's disease. Brain. 2021 Mar 03; 144(2):357-359.
Starr P, Little S. PMID: 33693692.
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Humans
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Acute effects of adaptive Deep Brain Stimulation in Parkinson's disease. Brain Stimul. 2020 Nov - Dec; 13(6):1507-1516.
Piña-Fuentes D, van Dijk JMC, van Zijl JC, Moes HR, van Laar T, Oterdoom DLM, Little S, Brown P, Beudel M. PMID: 32738409.
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1 Fields:
Translation:
Humans
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Proceedings of the Seventh Annual Deep Brain Stimulation Think Tank: Advances in Neurophysiology, Adaptive DBS, Virtual Reality, Neuroethics and Technology. Front Hum Neurosci. 2020; 14:54.
Ramirez-Zamora A, Giordano J, Gunduz A, Alcantara J, Cagle JN, Cernera S, Difuntorum P, Eisinger RS, Gomez J, Long S, Parks B, Wong JK, Chiu S, Patel B, Grill WM, Walker HC, Little SJ, Gilron R, Tinkhauser G, Thevathasan W, Sinclair NC, Lozano AM, Foltynie T, Fasano A, Sheth SA, Scangos K, Sanger TD, Miller J, Brumback AC, Rajasethupathy P, McIntyre C, Schlachter L, Suthana N, Kubu C, Sankary LR, Herrera-Ferrá K, Goetz S, Cheeran B, Steinke GK, Hess C, Almeida L, Deeb W, Foote KD, Okun MS. PMID: 32292333.
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Prefrontal-Subthalamic Hyperdirect Pathway Modulates Movement Inhibition in Humans. Neuron. 2020 05 20; 106(4):579-588.e3.
Chen W, de Hemptinne C, Miller AM, Leibbrand M, Little SJ, Lim DA, Larson PS, Starr PA. PMID: 32155442.
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16 Fields:
Translation:
Humans
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Debugging Adaptive Deep Brain Stimulation for Parkinson's Disease. Mov Disord. 2020 04; 35(4):555-561.
Little S, Brown P. PMID: 32039501.
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5 Fields:
Translation:
Humans
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Adaptive deep brain stimulation as advanced Parkinson's disease treatment (ADAPT study): protocol for a pseudo-randomised clinical study. BMJ Open. 2019 06 14; 9(6):e029652.
Piña-Fuentes D, Beudel M, Little S, Brown P, Oterdoom DLM, van Dijk JMC. PMID: 31201193.
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PubMed Mentions:
5 Fields:
Translation:
HumansCTClinical Trials
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Phase-Dependent Suppression of Beta Oscillations in Parkinson's Disease Patients. J Neurosci. 2019 02 06; 39(6):1119-1134.
Holt AB, Kormann E, Gulberti A, Pötter-Nerger M, McNamara CG, Cagnan H, Baaske MK, Little S, Köppen JA, Buhmann C, Westphal M, Gerloff C, Engel AK, Brown P, Hamel W, Moll CKE, Sharott A. PMID: 30552179.
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15 Fields:
Translation:
HumansCells
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The characteristics of pallidal low-frequency and beta bursts could help implementing adaptive brain stimulation in the parkinsonian and dystonic internal globus pallidus. Neurobiol Dis. 2019 01; 121:47-57.
Piña-Fuentes D, van Zijl JC, van Dijk JMC, Little S, Tinkhauser G, Oterdoom DLM, Tijssen MAJ, Beudel M. PMID: 30227227.
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10 Fields:
Translation:
Humans
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Parkinsonian Tremor Detection from Subthalamic Nucleus Local Field Potentials for Closed-Loop Deep Brain Stimulation. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul; 2018:2320-2324.
Shah SA, Tinkhauser G, Chen CC, Little S, Brown P. PMID: 30440871.
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Alternating Modulation of Subthalamic Nucleus Beta Oscillations during Stepping. J Neurosci. 2018 05 30; 38(22):5111-5121.
Fischer P, Chen CC, Chang YJ, Yeh CH, Pogosyan A, Herz DM, Cheeran B, Green AL, Aziz TZ, Hyam J, Little S, Foltynie T, Limousin P, Zrinzo L, Hasegawa H, Samuel M, Ashkan K, Brown P, Tan H. PMID: 29760182.
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14 Fields:
Translation:
Humans
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Mechanisms Underlying Decision-Making as Revealed by Deep-Brain Stimulation in Patients with Parkinson's Disease. Curr Biol. 2018 04 23; 28(8):1169-1178.e6.
Herz DM, Little S, Pedrosa DJ, Tinkhauser G, Cheeran B, Foltynie T, Bogacz R, Brown P. PMID: 29606416.
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17 Fields:
Translation:
Humans
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Subthalamic nucleus gamma activity increases not only during movement but also during movement inhibition. Elife. 2017 07 25; 6.
Fischer P, Pogosyan A, Herz DM, Cheeran B, Green AL, Fitzgerald J, Aziz TZ, Hyam J, Little S, Foltynie T, Limousin P, Zrinzo L, Brown P, Tan H. PMID: 28742498.
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13 Fields:
Translation:
Humans
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Adaptive DBS in a Parkinson's patient with chronically implanted DBS: A proof of principle. Mov Disord. 2017 08; 32(8):1253-1254.
Piña-Fuentes D, Little S, Oterdoom M, Neal S, Pogosyan A, Tijssen MAJ, van Laar T, Brown P, van Dijk JMC, Beudel M. PMID: 28589687.
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20 Fields:
Translation:
Humans
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The modulatory effect of adaptive deep brain stimulation on beta bursts in Parkinson's disease. Brain. 2017 Apr 01; 140(4):1053-1067.
Tinkhauser G, Pogosyan A, Little S, Beudel M, Herz DM, Tan H, Brown P. PMID: 28334851.
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88 Fields:
Translation:
Humans
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Subthalamic nucleus beta and gamma activity is modulated depending on the level of imagined grip force. Exp Neurol. 2017 07; 293:53-61.
Fischer P, Pogosyan A, Cheeran B, Green AL, Aziz TZ, Hyam J, Little S, Foltynie T, Limousin P, Zrinzo L, Hariz M, Samuel M, Ashkan K, Brown P, Tan H. PMID: 28342747.
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PubMed Mentions:
8 Fields:
Translation:
Humans
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Distinct mechanisms mediate speed-accuracy adjustments in cortico-subthalamic networks. Elife. 2017 01 31; 6.
Herz DM, Tan H, Brittain JS, Fischer P, Cheeran B, Green AL, FitzGerald J, Aziz TZ, Ashkan K, Little S, Foltynie T, Limousin P, Zrinzo L, Bogacz R, Brown P. PMID: 28137358.
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16 Fields:
Translation:
Humans
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Stimulating at the right time: phase-specific deep brain stimulation. Brain. 2017 01; 140(1):132-145.
Cagnan H, Pedrosa D, Little S, Pogosyan A, Cheeran B, Aziz T, Green A, Fitzgerald J, Foltynie T, Limousin P, Zrinzo L, Hariz M, Friston KJ, Denison T, Brown P. PMID: 28007997.
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PubMed Mentions:
51 Fields:
Translation:
Humans
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Adaptive deep brain stimulation for Parkinson's disease demonstrates reduced speech side effects compared to conventional stimulation in the acute setting. J Neurol Neurosurg Psychiatry. 2016 12; 87(12):1388-1389.
Little S, Tripoliti E, Beudel M, Pogosyan A, Cagnan H, Herz D, Bestmann S, Aziz T, Cheeran B, Zrinzo L, Hariz M, Hyam J, Limousin P, Foltynie T, Brown P. PMID: 27530809.
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PubMed Mentions:
51 Fields:
Translation:
Humans
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Decisions Made with Less Evidence Involve Higher Levels of Corticosubthalamic Nucleus Theta Band Synchrony. J Cogn Neurosci. 2016 06; 28(6):811-25.
Zavala B, Tan H, Little S, Ashkan K, Green AL, Aziz T, Foltynie T, Zrinzo L, Zaghloul K, Brown P. PMID: 26845109.
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PubMed Mentions:
8 Fields:
Translation:
Humans
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Bilateral adaptive deep brain stimulation is effective in Parkinson's disease. J Neurol Neurosurg Psychiatry. 2016 07; 87(7):717-21.
Little S, Beudel M, Zrinzo L, Foltynie T, Limousin P, Hariz M, Neal S, Cheeran B, Cagnan H, Gratwicke J, Aziz TZ, Pogosyan A, Brown P. PMID: 26424898.
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PubMed Mentions:
62 Fields:
Translation:
Humans
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Tremor Reduction by Deep Brain Stimulation Is Associated With Gamma Power Suppression in Parkinson's Disease. Neuromodulation. 2015 Jul; 18(5):349-54.
Beudel M, Little S, Pogosyan A, Ashkan K, Foltynie T, Limousin P, Zrinzo L, Hariz M, Bogdanovic M, Cheeran B, Green AL, Aziz T, Thevathasan W, Brown P. PMID: 25879998.
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19 Fields:
Translation:
Humans
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Excessive neural synchrony in Machado-Joseph disease responsive to subthalamic nucleus stimulation. Mov Disord. 2015 Mar; 30(3):437-8.
Anzak A, Little S, Hulse N, Andrews T, Brown P, Samuel M, Ashkan K. PMID: 25689061.
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Translation:
Humans
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The nature of tremor circuits in parkinsonian and essential tremor. Brain. 2014 Dec; 137(Pt 12):3223-34.
Cagnan H, Little S, Foltynie T, Limousin P, Zrinzo L, Hariz M, Cheeran B, Fitzgerald J, Green AL, Aziz T, Brown P. PMID: 25200741.
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24 Fields:
Translation:
Humans
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Controlling Parkinson's disease with adaptive deep brain stimulation. J Vis Exp. 2014 Jul 16; (89).
Little S, Pogosyan A, Neal S, Zrinzo L, Hariz M, Foltynie T, Limousin P, Brown P. PMID: 25077449.
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7 Fields:
Translation:
Humans
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Midline frontal cortex low-frequency activity drives subthalamic nucleus oscillations during conflict. J Neurosci. 2014 May 21; 34(21):7322-33.
Zavala BA, Tan H, Little S, Ashkan K, Hariz M, Foltynie T, Zrinzo L, Zaghloul KA, Brown P. PMID: 24849364.
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PubMed Mentions:
48 Fields:
Translation:
Humans
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The functional role of beta oscillations in Parkinson's disease. Parkinsonism Relat Disord. 2014 Jan; 20 Suppl 1:S44-8.
Little S, Brown P. PMID: 24262186.
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65 Fields:
Translation:
Humans
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Bilateral functional connectivity of the basal ganglia in patients with Parkinson's disease and its modulation by dopaminergic treatment. PLoS One. 2013; 8(12):e82762.
Little S, Tan H, Anzak A, Pogosyan A, Kühn A, Brown P. PMID: 24376574.
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PubMed Mentions:
23 Fields:
Translation:
Humans
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Phase dependent modulation of tremor amplitude in essential tremor through thalamic stimulation. Brain. 2013 Oct; 136(Pt 10):3062-75.
Cagnan H, Brittain JS, Little S, Foltynie T, Limousin P, Zrinzo L, Hariz M, Joint C, Fitzgerald J, Green AL, Aziz T, Brown P. PMID: 24038075.
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PubMed Mentions:
32 Fields:
Translation:
Humans
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Adaptive deep brain stimulation in advanced Parkinson disease. Ann Neurol. 2013 Sep; 74(3):449-57.
Little S, Pogosyan A, Neal S, Zavala B, Zrinzo L, Hariz M, Foltynie T, Limousin P, Ashkan K, FitzGerald J, Green AL, Aziz TZ, Brown P. PMID: 23852650.
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PubMed Mentions:
280 Fields:
Translation:
Humans
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Telemedicine for peer-to-peer psychiatry learning between U.K. and Somaliland medical students. Acad Psychiatry. 2013 May 01; 37(3):182-6.
Keynejad R, Ali FR, Finlayson AE, Handuleh J, Adam G, Bowen JS, Leather A, Little SJ, Whitwell S. PMID: 23632929.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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What brain signals are suitable for feedback control of deep brain stimulation in Parkinson's disease? Ann N Y Acad Sci. 2012 Aug; 1265:9-24.
Little S, Brown P. PMID: 22830645.
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PubMed Mentions:
79 Fields:
Translation:
Humans
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A torque-based method demonstrates increased rigidity in Parkinson's disease during low-frequency stimulation. Exp Brain Res. 2012 Jun; 219(4):499-506.
Little S, Joundi RA, Tan H, Pogosyan A, Forrow B, Joint C, Green AL, Aziz TZ, Brown P. PMID: 22580572.
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PubMed Mentions:
6 Fields:
Translation:
Humans
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An international, case-based, distance-learning collaboration between the UK and Somaliland using a real-time clinical education website. J Telemed Telecare. 2010; 16(4):181-4.
Finlayson AE, Baraco A, Cronin N, Johnson O, Little S, Nuur A, Tanasie D, Leather A. PMID: 20511568.
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PubMed Mentions:
11 Fields:
Translation:
Humans