Simon Little, PhD

Title(s)Assistant Professor, Neurology
SchoolSchool of Medicine
Address513 Parnassus Ave, HSE
San Francisco CA 94143
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    Title(s)UCSF Weill Institute for Neurosciences

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Long-term wireless streaming of neural recordings for circuit discovery and adaptive stimulation in individuals with Parkinson's disease. Nat Biotechnol. 2021 May 03. Gilron R, Little S, Perrone R, Wilt R, de Hemptinne C, Yaroshinsky MS, Racine CA, Wang SS, Ostrem JL, Larson PS, Wang DD, Galifianakis NB, Bledsoe IO, San Luciano M, Dawes HE, Worrell GA, Kremen V, Borton DA, Denison T, Starr PA. PMID: 33941932.
      View in: PubMed   Mentions:    Fields:    
    2. Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies. Front Hum Neurosci. 2021; 15:644593. Vedam-Mai V, Deisseroth K, Giordano J, Lazaro-Munoz G, Chiong W, Suthana N, Langevin JP, Gill J, Goodman W, Provenza NR, Halpern CH, Shivacharan RS, Cunningham TN, Sheth SA, Pouratian N, Scangos KW, Mayberg HS, Horn A, Johnson KA, Butson CR, Gilron R, de Hemptinne C, Wilt R, Yaroshinsky M, Little S, Starr P, Worrell G, Shirvalkar P, Chang E, Volkmann J, Muthuraman M, Groppa S, Kühn AA, Li L, Johnson M, Otto KJ, Raike R, Goetz S, Wu C, Silburn P, Cheeran B, Pathak YJ, Malekmohammadi M, Gunduz A, Wong JK, Cernera S, Wagle Shukla A, Ramirez-Zamora A, Deeb W, Patterson A, Foote KD, Okun MS. PMID: 33953663.
      View in: PubMed   Mentions:
    3. The Neurophysiology of Sleep in Parkinson's Disease. Mov Disord. 2021 Apr 07. Zahed H, Zuzuarregui JRP, Gilron R, Denison T, Starr PA, Little S. PMID: 33826171.
      View in: PubMed   Mentions:    Fields:    
    4. A space-time continuum in DBS: structural and functional advances in Parkinson's disease. Brain. 2021 Mar 03; 144(2):357-359. Starr P, Little S. PMID: 33693692.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Acute effects of adaptive Deep Brain Stimulation in Parkinson's disease. Brain Stimul. 2020 Nov - Dec; 13(6):1507-1516. Piña-Fuentes D, van Dijk JMC, van Zijl JC, Moes HR, van Laar T, Oterdoom DLM, Little S, Brown P, Beudel M. PMID: 32738409.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Proceedings of the Seventh Annual Deep Brain Stimulation Think Tank: Advances in Neurophysiology, Adaptive DBS, Virtual Reality, Neuroethics and Technology. Front Hum Neurosci. 2020; 14:54. Ramirez-Zamora A, Giordano J, Gunduz A, Alcantara J, Cagle JN, Cernera S, Difuntorum P, Eisinger RS, Gomez J, Long S, Parks B, Wong JK, Chiu S, Patel B, Grill WM, Walker HC, Little SJ, Gilron R, Tinkhauser G, Thevathasan W, Sinclair NC, Lozano AM, Foltynie T, Fasano A, Sheth SA, Scangos K, Sanger TD, Miller J, Brumback AC, Rajasethupathy P, McIntyre C, Schlachter L, Suthana N, Kubu C, Sankary LR, Herrera-Ferrá K, Goetz S, Cheeran B, Steinke GK, Hess C, Almeida L, Deeb W, Foote KD, Okun MS. PMID: 32292333.
      View in: PubMed   Mentions:
    7. Prefrontal-Subthalamic Hyperdirect Pathway Modulates Movement Inhibition in Humans. Neuron. 2020 05 20; 106(4):579-588.e3. Chen W, de Hemptinne C, Miller AM, Leibbrand M, Little SJ, Lim DA, Larson PS, Starr PA. PMID: 32155442.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    8. Debugging Adaptive Deep Brain Stimulation for Parkinson's Disease. Mov Disord. 2020 04; 35(4):555-561. Little S, Brown P. PMID: 32039501.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    9. Adaptive deep brain stimulation as advanced Parkinson's disease treatment (ADAPT study): protocol for a pseudo-randomised clinical study. BMJ Open. 2019 06 14; 9(6):e029652. Piña-Fuentes D, Beudel M, Little S, Brown P, Oterdoom DLM, van Dijk JMC. PMID: 31201193.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCTClinical Trials
    10. Phase-Dependent Suppression of Beta Oscillations in Parkinson's Disease Patients. J Neurosci. 2019 02 06; 39(6):1119-1134. Holt AB, Kormann E, Gulberti A, Pötter-Nerger M, McNamara CG, Cagnan H, Baaske MK, Little S, Köppen JA, Buhmann C, Westphal M, Gerloff C, Engel AK, Brown P, Hamel W, Moll CKE, Sharott A. PMID: 30552179.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    11. The characteristics of pallidal low-frequency and beta bursts could help implementing adaptive brain stimulation in the parkinsonian and dystonic internal globus pallidus. Neurobiol Dis. 2019 01; 121:47-57. Piña-Fuentes D, van Zijl JC, van Dijk JMC, Little S, Tinkhauser G, Oterdoom DLM, Tijssen MAJ, Beudel M. PMID: 30227227.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    12. Parkinsonian Tremor Detection from Subthalamic Nucleus Local Field Potentials for Closed-Loop Deep Brain Stimulation. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul; 2018:2320-2324. Shah SA, Tinkhauser G, Chen CC, Little S, Brown P. PMID: 30440871.
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    13. Alternating Modulation of Subthalamic Nucleus Beta Oscillations during Stepping. J Neurosci. 2018 05 30; 38(22):5111-5121. Fischer P, Chen CC, Chang YJ, Yeh CH, Pogosyan A, Herz DM, Cheeran B, Green AL, Aziz TZ, Hyam J, Little S, Foltynie T, Limousin P, Zrinzo L, Hasegawa H, Samuel M, Ashkan K, Brown P, Tan H. PMID: 29760182.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    14. Mechanisms Underlying Decision-Making as Revealed by Deep-Brain Stimulation in Patients with Parkinson's Disease. Curr Biol. 2018 04 23; 28(8):1169-1178.e6. Herz DM, Little S, Pedrosa DJ, Tinkhauser G, Cheeran B, Foltynie T, Bogacz R, Brown P. PMID: 29606416.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    15. Subthalamic nucleus gamma activity increases not only during movement but also during movement inhibition. Elife. 2017 07 25; 6. Fischer P, Pogosyan A, Herz DM, Cheeran B, Green AL, Fitzgerald J, Aziz TZ, Hyam J, Little S, Foltynie T, Limousin P, Zrinzo L, Brown P, Tan H. PMID: 28742498.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    16. Adaptive DBS in a Parkinson's patient with chronically implanted DBS: A proof of principle. Mov Disord. 2017 08; 32(8):1253-1254. Piña-Fuentes D, Little S, Oterdoom M, Neal S, Pogosyan A, Tijssen MAJ, van Laar T, Brown P, van Dijk JMC, Beudel M. PMID: 28589687.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    17. The modulatory effect of adaptive deep brain stimulation on beta bursts in Parkinson's disease. Brain. 2017 Apr 01; 140(4):1053-1067. Tinkhauser G, Pogosyan A, Little S, Beudel M, Herz DM, Tan H, Brown P. PMID: 28334851.
      View in: PubMed   Mentions: 88     Fields:    Translation:Humans
    18. Subthalamic nucleus beta and gamma activity is modulated depending on the level of imagined grip force. Exp Neurol. 2017 07; 293:53-61. Fischer P, Pogosyan A, Cheeran B, Green AL, Aziz TZ, Hyam J, Little S, Foltynie T, Limousin P, Zrinzo L, Hariz M, Samuel M, Ashkan K, Brown P, Tan H. PMID: 28342747.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    19. Distinct mechanisms mediate speed-accuracy adjustments in cortico-subthalamic networks. Elife. 2017 01 31; 6. Herz DM, Tan H, Brittain JS, Fischer P, Cheeran B, Green AL, FitzGerald J, Aziz TZ, Ashkan K, Little S, Foltynie T, Limousin P, Zrinzo L, Bogacz R, Brown P. PMID: 28137358.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    20. Stimulating at the right time: phase-specific deep brain stimulation. Brain. 2017 01; 140(1):132-145. Cagnan H, Pedrosa D, Little S, Pogosyan A, Cheeran B, Aziz T, Green A, Fitzgerald J, Foltynie T, Limousin P, Zrinzo L, Hariz M, Friston KJ, Denison T, Brown P. PMID: 28007997.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    21. Adaptive deep brain stimulation for Parkinson's disease demonstrates reduced speech side effects compared to conventional stimulation in the acute setting. J Neurol Neurosurg Psychiatry. 2016 12; 87(12):1388-1389. Little S, Tripoliti E, Beudel M, Pogosyan A, Cagnan H, Herz D, Bestmann S, Aziz T, Cheeran B, Zrinzo L, Hariz M, Hyam J, Limousin P, Foltynie T, Brown P. PMID: 27530809.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    22. Decisions Made with Less Evidence Involve Higher Levels of Corticosubthalamic Nucleus Theta Band Synchrony. J Cogn Neurosci. 2016 06; 28(6):811-25. Zavala B, Tan H, Little S, Ashkan K, Green AL, Aziz T, Foltynie T, Zrinzo L, Zaghloul K, Brown P. PMID: 26845109.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    23. Bilateral adaptive deep brain stimulation is effective in Parkinson's disease. J Neurol Neurosurg Psychiatry. 2016 07; 87(7):717-21. Little S, Beudel M, Zrinzo L, Foltynie T, Limousin P, Hariz M, Neal S, Cheeran B, Cagnan H, Gratwicke J, Aziz TZ, Pogosyan A, Brown P. PMID: 26424898.
      View in: PubMed   Mentions: 62     Fields:    Translation:Humans
    24. Tremor Reduction by Deep Brain Stimulation Is Associated With Gamma Power Suppression in Parkinson's Disease. Neuromodulation. 2015 Jul; 18(5):349-54. Beudel M, Little S, Pogosyan A, Ashkan K, Foltynie T, Limousin P, Zrinzo L, Hariz M, Bogdanovic M, Cheeran B, Green AL, Aziz T, Thevathasan W, Brown P. PMID: 25879998.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    25. Excessive neural synchrony in Machado-Joseph disease responsive to subthalamic nucleus stimulation. Mov Disord. 2015 Mar; 30(3):437-8. Anzak A, Little S, Hulse N, Andrews T, Brown P, Samuel M, Ashkan K. PMID: 25689061.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    26. The nature of tremor circuits in parkinsonian and essential tremor. Brain. 2014 Dec; 137(Pt 12):3223-34. Cagnan H, Little S, Foltynie T, Limousin P, Zrinzo L, Hariz M, Cheeran B, Fitzgerald J, Green AL, Aziz T, Brown P. PMID: 25200741.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    27. Controlling Parkinson's disease with adaptive deep brain stimulation. J Vis Exp. 2014 Jul 16; (89). Little S, Pogosyan A, Neal S, Zrinzo L, Hariz M, Foltynie T, Limousin P, Brown P. PMID: 25077449.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    28. Midline frontal cortex low-frequency activity drives subthalamic nucleus oscillations during conflict. J Neurosci. 2014 May 21; 34(21):7322-33. Zavala BA, Tan H, Little S, Ashkan K, Hariz M, Foltynie T, Zrinzo L, Zaghloul KA, Brown P. PMID: 24849364.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    29. The functional role of beta oscillations in Parkinson's disease. Parkinsonism Relat Disord. 2014 Jan; 20 Suppl 1:S44-8. Little S, Brown P. PMID: 24262186.
      View in: PubMed   Mentions: 65     Fields:    Translation:Humans
    30. Bilateral functional connectivity of the basal ganglia in patients with Parkinson's disease and its modulation by dopaminergic treatment. PLoS One. 2013; 8(12):e82762. Little S, Tan H, Anzak A, Pogosyan A, Kühn A, Brown P. PMID: 24376574.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    31. Phase dependent modulation of tremor amplitude in essential tremor through thalamic stimulation. Brain. 2013 Oct; 136(Pt 10):3062-75. Cagnan H, Brittain JS, Little S, Foltynie T, Limousin P, Zrinzo L, Hariz M, Joint C, Fitzgerald J, Green AL, Aziz T, Brown P. PMID: 24038075.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    32. Adaptive deep brain stimulation in advanced Parkinson disease. Ann Neurol. 2013 Sep; 74(3):449-57. Little S, Pogosyan A, Neal S, Zavala B, Zrinzo L, Hariz M, Foltynie T, Limousin P, Ashkan K, FitzGerald J, Green AL, Aziz TZ, Brown P. PMID: 23852650.
      View in: PubMed   Mentions: 280     Fields:    Translation:Humans
    33. Telemedicine for peer-to-peer psychiatry learning between U.K. and Somaliland medical students. Acad Psychiatry. 2013 May 01; 37(3):182-6. Keynejad R, Ali FR, Finlayson AE, Handuleh J, Adam G, Bowen JS, Leather A, Little SJ, Whitwell S. PMID: 23632929.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    34. What brain signals are suitable for feedback control of deep brain stimulation in Parkinson's disease? Ann N Y Acad Sci. 2012 Aug; 1265:9-24. Little S, Brown P. PMID: 22830645.
      View in: PubMed   Mentions: 79     Fields:    Translation:Humans
    35. A torque-based method demonstrates increased rigidity in Parkinson's disease during low-frequency stimulation. Exp Brain Res. 2012 Jun; 219(4):499-506. Little S, Joundi RA, Tan H, Pogosyan A, Forrow B, Joint C, Green AL, Aziz TZ, Brown P. PMID: 22580572.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    36. An international, case-based, distance-learning collaboration between the UK and Somaliland using a real-time clinical education website. J Telemed Telecare. 2010; 16(4):181-4. Finlayson AE, Baraco A, Cronin N, Johnson O, Little S, Nuur A, Tanasie D, Leather A. PMID: 20511568.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
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