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Myriam Chaumeil, PhD

Title(s)Assistant Professor, Physical Therapy
SchoolSchool of Medicine
Phone415-216-5634
ORCID ORCID Icon0000-0002-2110-4613 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral Fellowship2014Radiology and Biomedical Imaging
    NeuroSpinPh.D. in Medical Physics2008Medicine
    ESPCIEngineer Degree2005Paris Technology
    University of Orsay, Paris XIMaster of Science2005Medicine
    University of California, San Francisco, CA2018Diversity, Equity, and Inclusion Champion Training
    Collapse Awards and Honors
    Conrad Hilton Foundation2017  - 2019Marilyn Hilton Award for Innovation in MS Research
    The Dana Foundation2017  - 2019David Mahoney Neuroimaging Grant
    California Brain Initiative2015  - 2017Cal-BRAIN Pilot Award
    UCSF2013Bruce Hasegawa Award For Excellence in Biomedical Imaging
    UCSF2013Margaret H. Surbeck - Young Investigator Award - 2nd place
    UCSF2011Margaret H. Surbeck - Young Investigator Award - 1st place
    UCSF2012Margaret H. Surbeck - Young Investigator Award - 3rd place
    ISMRM2012Junior Fellow of the Society
    ISMRM2010William Negendank Award for Excellence in Cancer Imaging
    American Brain Tumor Association2010  - 2012Post-doctoral Fellowship In Basic Science
    French Muscular Dystrophy Association2005  - 2008Ph.D. Fellowship

    Collapse Overview 
    Collapse Overview
    My research program is a direct reflection of my dual education in biology and Magnetic Resonance (MR) physics, and builds upon the synergy between these two fields. I believe that biological discoveries should drive the design of sensitive, specific and clinically translatable MR imaging methods that can improve diagnosis, prognosis and monitoring of therapeutic response. I also trust that thoughtfully applied MR techniques can uncover new biological mechanisms, further our understanding of pathogenic processes and help to identify potential therapeutic targets.

    Among all MR methods, the hyperpolarized 13C dissolution dynamic nuclear polarization (DNP) methodology was a thrilling discovery for me, and a perfect fit for my multidisciplinary background. This methodology has been at the center of my research since I move to UCSF as a post-doc. There, I have had the opportunity to learn all aspects of this exciting specialty from internationally recognized scientists, from polarizer hardware to dedicated acquisition schemes. On the biochemistry side, I have developed a high interest in the design and optimization of hyperpolarized probes, from the chemical conceptualization to the requirements for clinical translation.

    I am an Assistant Professor in residence in the departments of Physical Therapy and Rehabilitation Science, and Radiology and Biomedical Imaging at UCSF. I am also the Associate Director of the Preclinical MR Imaging and Spectroscopy, as well as a member of the UCSF Biomedical Sciences Graduate Program and the UC Berkeley-UCSF Graduate Program in Bioengineering. My lab focuses on preclinically developing and biologically validating hyperpolarized 13C methods for in vivo measurement of brain metabolism, in physiological and pathological conditions. We have a particular interest in expanding the use of MR metabolic imaging to the study of neurodegeneration and neuroinflammation using preclinical models of Multiple Sclerosis (MS), Traumatic Brain Injury, Alzheimer’s disease (AD), CNS lymphomas and vascular dementia. While our main field of expertise is preclinical imaging, our ultimate goal is to have a positive impact on healthcare, designing imaging solutions aiming at refining diagnosis, prognosis and therapeutic regimen in a patient-specific way.

    Collapse Research 
    Collapse Research Activities and Funding
    Development and validation of novel models for cerebral small vessel disease and vascular cognitive impairment
    NIH/NINDS R61NS115132Sep 18, 2019 - Aug 31, 2021
    Role: Co-Principal Investigator
    Understand and probing disrupted glucose metabolism in Alzheimer's disease
    NIH/NIA R01AG064170Aug 1, 2019 - Mar 31, 2024
    Role: Co-Principal Investigator
    Application of Hyperpolarized 13C Magnetic Resonance Imaging to Detect Target Inhibition of NF-kB Activation and Response in Primary CNS Lymphoma
    NIH/NCI R01CA239462Jul 4, 2019 - Jun 30, 2024
    Role: Co-Principal Investigator
    MR metabolic Imaging of Multiple Sclerosis
    NIH/NINDS R01NS102156Sep 1, 2017 - May 31, 2022
    Role: Principal Investigator
    In vivo metabolic imaging of neuroinflammation after TBI
    NIH/NINDS R21NS096718Feb 1, 2016 - Jan 31, 2018
    Role: Co-Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse Collaboration Interests
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Chung BT, Chen HY, Gordon J, Mammoli D, Sriram R, Autry AW, Le Page LM, Chaumeil M, Shin P, Slater J, Tan CT, Suszczynski C, Chang S, Li Y, Bok RA, Ronen SM, Larson PEZ, Kurhanewicz J, Vigneron DB. First hyperpolarized [2-13C]pyruvate MR studies of human brain metabolism. J Magn Reson. 2019 Oct 08; 309:106617. PMID: 31648132.
      View in: PubMed
    2. Le Page LM, Guglielmetti C, Najac CF, Tiret B, Chaumeil MM. Hyperpolarized 13 C magnetic resonance spectroscopy detects toxin-induced neuroinflammation in mice. NMR Biomed. 2019 Nov; 32(11):e4164. PMID: 31437326.
      View in: PubMed
    3. Radoul M, Najac C, Viswanath P, Mukherjee J, Kelly M, Gillespie AM, Chaumeil MM, Eriksson P, Delos Santos R, Pieper RO, Ronen SM. HDAC inhibition in glioblastoma monitored by hyperpolarized 13 C MRSI. NMR Biomed. 2019 02; 32(2):e4044. PMID: 30561869.
      View in: PubMed
    4. Huimin Geng, Brice Tiret, Hua-Xin Gao, Cigall Kadoch, Ming Lu, Lingjing Chen, Ilwoo Park, Gerd Melkus, Adam Elkhaled, John Kurhanewicz, Lisa Drew, Sebastien Degorce, Michele Mayo, Keith Dillman, Rana Anjum, Andrew Bloecher, Myriam Chaumeil, James Rubenstein. Application of Hyperpolarized 13C Magnetic Resonance Imaging to Detect Target Inhibition of NFkB Activation in Preclinical Patient-Derived Models of CNS Lymphoma. Blood. 2018 Nov 29; 132(Supplement 1):2840-2840.
      View in: Publisher Site
    5. Krukowski K, Chou A, Feng X, Tiret B, Paladini MS, Riparip LK, Chaumeil MM, Lemere C, Rosi S. Traumatic Brain Injury in Aged Mice Induces Chronic Microglia Activation, Synapse Loss, and Complement-Dependent Memory Deficits. Int J Mol Sci. 2018 Nov 26; 19(12). PMID: 30486287.
      View in: PubMed
    6. Nolan A, Hennessy E, Krukowski K, Guglielmetti C, Chaumeil MM, Sohal VS, Rosi S. Repeated Mild Head Injury Leads to Wide-Ranging Deficits in Higher-Order Cognitive Functions Associated with the Prefrontal Cortex. J Neurotrauma. 2018 10 15; 35(20):2425-2434. PMID: 29732949.
      View in: PubMed
    7. Guglielmetti C, Chou A, Krukowski K, Najac C, Feng X, Riparip LK, Rosi S, Chaumeil MM. In vivo metabolic imaging of Traumatic Brain Injury. Sci Rep. 2017 12 13; 7(1):17525. PMID: 29235509.
      View in: PubMed
    8. Marina Radoul, Myriam M Chaumeil, Pia Eriksson, Chloe Najac, Pavithra Viswanath, Anne Marie Gillespie, Joydeep Mukherjee, Russell Pieper, Sabrina Ronen. TMOD-20. EARLY DETECTION OF HDAC INHIBITION IN GLIOBLASTOMA USING ADVANCED HYPERPOLARIZED 13C MRSI. Neuro-Oncology. 2017 Nov 6; 19(suppl_6):vi258-vi258.
      View in: Publisher Site
    9. Brice Tiret, Adam Autry, Ilwoo Park, Ming Lu, Rana Anjum, Liza Drew, Sebastien Degorce, Michele Mayo, Keith Dillman, James Rubenstein, Myriam M Chaumeil. EXTH-71. HYPERPOLARIZED [1-13C] PYRUVATE AS A BIOMARKER FOR TREATMENT MONITORING IN LYMPHOMA MURINE MODELS. Neuro-Oncology. 2017 Nov 6; 19(suppl_6):vi88-vi88.
      View in: Publisher Site
    10. Chloe Najac, Marina Radoul, Pavithra Viswanath, Myriam M Chaumeil, Sabrina Ronen. METB-14. DOWN-REGULATION OF ACETATE METABOLISM TOWARDS FATTY ACIDS IN IDH1 MUTANT GLIOMA. Neuro-Oncology. 2017 Nov 6; 19(suppl_6):vi131-vi131.
      View in: Publisher Site
    11. Guglielmetti C, Najac C, Didonna A, Van der Linden A, Ronen SM, Chaumeil MM. Hyperpolarized 13C MR metabolic imaging can detect neuroinflammation in vivo in a multiple sclerosis murine model. Proc Natl Acad Sci U S A. 2017 08 15; 114(33):E6982-E6991. PMID: 28760957.
      View in: PubMed
    12. Chloe Najac, Myriam M. Chaumeil, Gary Kohanbash, Caroline Guglielmetti, Jeremy Gordon, Hideho Okada, Sabrina M. Ronen. IMST-04. IMAGING INFLAMMATORY CELL FUNCTION USING 13C MAGNETIC RESONANCE SPECTROSCOPY OF HYPERPOLARIZED 6-13C-LABELED ARGININE. Neuro-Oncology. 2016 Nov 1; 18(suppl_6):vi86-vi86.
      View in: Publisher Site
    13. Najac C, Chaumeil MM, Kohanbash G, Guglielmetti C, Gordon JW, Okada H, Ronen SM. Detection of inflammatory cell function using (13)C magnetic resonance spectroscopy of hyperpolarized [6-(13)C]-arginine. Sci Rep. 2016 08 10; 6:31397. PMID: 27507680.
      View in: PubMed
    14. Chaumeil MM, Radoul M, Najac C, Eriksson P, Viswanath P, Blough MD, Chesnelong C, Luchman HA, Cairncross JG, Ronen SM. Hyperpolarized (13)C MR imaging detects no lactate production in mutant IDH1 gliomas: Implications for diagnosis and response monitoring. Neuroimage Clin. 2016; 12:180-9. PMID: 27437179.
      View in: PubMed
    15. Reed GD, von Morze C, Verkman AS, Koelsch BL, Chaumeil MM, Lustig M, Ronen SM, Bok RA, Sands JM, Larson PE, Wang ZJ, Larsen JH, Kurhanewicz J, Vigneron DB. Imaging Renal Urea Handling in Rats at Millimeter Resolution using Hyperpolarized Magnetic Resonance Relaxometry. Tomography. 2016 Jun; 2(2):125-135. PMID: 27570835.
      View in: PubMed
    16. Viswanath P, Chaumeil MM, Ronen SM. Molecular Imaging of Metabolic Reprograming in Mutant IDH Cells. Front Oncol. 2016; 6:60. PMID: 27014635.
      View in: PubMed
    17. Radoul M, Chaumeil MM, Eriksson P, Wang AS, Phillips JJ, Ronen SM. MR Studies of Glioblastoma Models Treated with Dual PI3K/mTOR Inhibitor and Temozolomide:Metabolic Changes Are Associated with Enhanced Survival. Mol Cancer Ther. 2016 05; 15(5):1113-22. PMID: 26883274.
      View in: PubMed
    18. Pavithra Viswanath, Jose L. Izquierdo-Garcia, Pia Eriksson, Larry Cai, Marina Radoul, Myriam M. Chaumeil, Michael Blough, H. Artee Luchmann, Samuel Weiss, J. Gregory Cairncross, Joanna J. Phillips, Russell O. Pieper, Sabrina M. Ronen. CBIO-42DOWN REGULATION OF PYRUVATE DEHYDROGENASE ACTIVITY IS ESSENTIAL FOR CELL PROLIFERATION IN IDH1 MUTANT GLIOMA CELLS. Neuro-Oncology. 2015 Nov 1; 17(suppl_5):v63-v63.
      View in: Publisher Site
    19. Chaumeil MM, Lupo JM, Ronen SM. Magnetic Resonance (MR) Metabolic Imaging in Glioma. Brain Pathol. 2015 Nov; 25(6):769-80. PMID: 26526945.
      View in: PubMed
    20. Chaumeil MM, Najac C, Ronen SM. Studies of Metabolism Using (13)C MRS of Hyperpolarized Probes. Methods Enzymol. 2015; 561:1-71. PMID: 26358901.
      View in: PubMed
    21. Izquierdo-Garcia JL, Viswanath P, Eriksson P, Cai L, Radoul M, Chaumeil MM, Blough M, Luchman HA, Weiss S, Cairncross JG, Phillips JJ, Pieper RO, Ronen SM. IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism. Cancer Res. 2015 Aug 01; 75(15):2999-3009. PMID: 26045167.
      View in: PubMed
    22. Izquierdo-Garcia JL, Viswanath P, Eriksson P, Chaumeil MM, Pieper RO, Phillips JJ, Ronen SM. Metabolic reprogramming in mutant IDH1 glioma cells. PLoS One. 2015; 10(2):e0118781. PMID: 25706986.
      View in: PubMed
    23. Jose Izquierdo-Garcia, Pia Eriksson, Larry Cai, Myriam Chaumeil, Russell Pieper, Joanna Phillips, Sabrina Ronen. TM-0713C MRS DETECTS METABOLIC FLUX ADAPTATION IN IDH MUTANT GLIOMA CELLS. Neuro-Oncology. 2014 Nov 1; 16(suppl_5):v214-v214.
      View in: Publisher Site
    24. Myriam Chaumeil, Peder Larson, Sarah Woods, Larry Cai, Pia Eriksson, Aaron Robinson, Janine Lupo, Daniel Vigneron, Sarah Nelson, Russell Pieper, Joanna Phillips, Sabrina Ronen. BI-07HYPERPOLARIZED [1-13C] GLUTAMATE: A METABOLIC IMAGING BIOMARKER OF IDH1 MUTATIONAL STATUS IN GLIOMA. Neuro-Oncology. 2014 Nov 1; 16(suppl_5):v24-v24.
      View in: Publisher Site
    25. Park I, Mukherjee J, Ito M, Chaumeil MM, Jalbert LE, Gaensler K, Ronen SM, Nelson SJ, Pieper RO. Changes in pyruvate metabolism detected by magnetic resonance imaging are linked to DNA damage and serve as a sensor of temozolomide response in glioblastoma cells. Cancer Res. 2014 Dec 01; 74(23):7115-24. PMID: 25320009.
      View in: PubMed
    26. Izquierdo-Garcia JL, Cai LM, Chaumeil MM, Eriksson P, Robinson AE, Pieper RO, Phillips JJ, Ronen SM. Glioma cells with the IDH1 mutation modulate metabolic fractional flux through pyruvate carboxylase. PLoS One. 2014; 9(9):e108289. PMID: 25243911.
      View in: PubMed
    27. Koelsch BL, Reed GD, Keshari KR, Chaumeil MM, Bok R, Ronen SM, Vigneron DB, Kurhanewicz J, Larson PEZ. Rapid in vivo apparent diffusion coefficient mapping of hyperpolarized (13) C metabolites. Magn Reson Med. 2015 Sep; 74(3):622-633. PMID: 25213126.
      View in: PubMed
    28. Sabrina M. Ronen, Jose L. Izquierdo-Garcia, Myriam M. Chaumeil, Larry M. Cai, Joanna J. Phillips, Russell O. Pieper. METABOLIC IMAGING BIOMARKERS FOR MUTANT IDH1 GLIOMAS. Neuro-Oncology. 2014 Jul 1; 16(suppl_3):iii12-iii12.
      View in: Publisher Site
    29. Chaumeil MM, Larson PE, Woods SM, Cai L, Eriksson P, Robinson AE, Lupo JM, Vigneron DB, Nelson SJ, Pieper RO, Phillips JJ, Ronen SM. Hyperpolarized [1-13C] glutamate: a metabolic imaging biomarker of IDH1 mutational status in glioma. Cancer Res. 2014 Aug 15; 74(16):4247-57. PMID: 24876103.
      View in: PubMed
    30. Chesnelong C, Chaumeil MM, Blough MD, Al-Najjar M, Stechishin OD, Chan JA, Pieper RO, Ronen SM, Weiss S, Luchman HA, Cairncross JG. Lactate dehydrogenase A silencing in IDH mutant gliomas. Neuro Oncol. 2014 May; 16(5):686-95. PMID: 24366912.
      View in: PubMed
    31. Jahangiri A, De Lay M, Miller LM, Carbonell WS, Hu YL, Lu K, Tom MW, Paquette J, Tokuyasu TA, Tsao S, Marshall R, Perry A, Bjorgan KM, Chaumeil MM, Ronen SM, Bergers G, Aghi MK. Gene expression profile identifies tyrosine kinase c-Met as a targetable mediator of antiangiogenic therapy resistance. Clin Cancer Res. 2013 Apr 01; 19(7):1773-83. PMID: 23307858.
      View in: PubMed
    32. Chaumeil MM, Larson PE, Yoshihara HA, Danforth OM, Vigneron DB, Nelson SJ, Pieper RO, Phillips JJ, Ronen SM. Non-invasive in vivo assessment of IDH1 mutational status in glioma. Nat Commun. 2013; 4:2429. PMID: 24019001.
      View in: PubMed
    33. Chaumeil MM, Gini B, Yang H, Iwanami A, Sukumar S, Ozawa T, Pieper RO, Mischel PS, James CD, Berger MS, Ronen SM. Longitudinal evaluation of MPIO-labeled stem cell biodistribution in glioblastoma using high resolution and contrast-enhanced MR imaging at 14.1 tesla. Neuro Oncol. 2012 Aug; 14(8):1050-61. PMID: 22670012.
      View in: PubMed
    34. Chaumeil MM, Valette J, Baligand C, Brouillet E, Hantraye P, Bloch G, Gaura V, Rialland A, Krystkowiak P, Verny C, Damier P, Remy P, Bachoud-Levi AC, Carlier P, Lebon V. pH as a biomarker of neurodegeneration in Huntington's disease: a translational rodent-human MRS study. J Cereb Blood Flow Metab. 2012 May; 32(5):771-9. PMID: 22373643.
      View in: PubMed
    35. Venkatesh HS, Chaumeil MM, Ward CS, Haas-Kogan DA, James CD, Ronen SM. Reduced phosphocholine and hyperpolarized lactate provide magnetic resonance biomarkers of PI3K/Akt/mTOR inhibition in glioblastoma. Neuro Oncol. 2012 Mar; 14(3):315-25. PMID: 22156546.
      View in: PubMed
    36. Chaumeil MM, Ozawa T, Park I, Scott K, James CD, Nelson SJ, Ronen SM. Hyperpolarized 13C MR spectroscopic imaging can be used to monitor Everolimus treatment in vivo in an orthotopic rodent model of glioblastoma. Neuroimage. 2012 Jan 02; 59(1):193-201. PMID: 21807103.
      View in: PubMed
    37. Ward CS, Venkatesh HS, Chaumeil MM, Brandes AH, Vancriekinge M, Dafni H, Sukumar S, Nelson SJ, Vigneron DB, Kurhanewicz J, James CD, Haas-Kogan DA, Ronen SM. Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy. Cancer Res. 2010 Feb 15; 70(4):1296-305. PMID: 20145128.
      View in: PubMed
    38. Chaumeil MM, Valette J, Guillermier M, Brouillet E, Boumezbeur F, Herard AS, Bloch G, Hantraye P, Lebon V. Multimodal neuroimaging provides a highly consistent picture of energy metabolism, validating 31P MRS for measuring brain ATP synthesis. Proc Natl Acad Sci U S A. 2009 Mar 10; 106(10):3988-93. PMID: 19234118.
      View in: PubMed
    39. Valette J, Chaumeil M, Guillermier M, Bloch G, Hantraye P, Lebon V. Diffusion-weighted NMR spectroscopy allows probing of 13C labeling of glutamate inside distinct metabolic compartments in the brain. Magn Reson Med. 2008 Aug; 60(2):306-11. PMID: 18666130.
      View in: PubMed
    40. Nadrigny F, Rivals I, Hirrlinger PG, Koulakoff A, Personnaz L, Vernet M, Allioux M, Chaumeil M, Ropert N, Giaume C, Kirchhoff F, Oheim M. Detecting fluorescent protein expression and co-localisation on single secretory vesicles with linear spectral unmixing. Eur Biophys J. 2006 Aug; 35(6):533-47. PMID: 16568270.
      View in: PubMed