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    Richard Schneider, PhD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentOrthopaedic Surgery
    Address513 Parnassus Ave, Med Sci
    San Francisco CA 94143
    Phone415-502-3788

       Overview 
       Overview
      Dr. Rich Schneider grew up in Maplewood, New Jersey. He graduated from Hampshire College in Amherst, Massachusetts in 1991. Following an undergraduate internship at the Smithsonian Institution in Washington, DC, Rich published his first paper, which was on the development and evolution of the skull in wolves and domestic dogs. He then received his Master's Degree in 1994 and his Doctoral Degree in 1998 from Duke University in Durham, North Carolina. Both of his graduate thesis projects focused on skeletal development and evolution in birds and mammals. Rich also studied embryology at the Marine Biological Laboratory in Woods Hole, Massachusetts, and at the Cold Spring Harbor Laboratory on Long Island, New York. For his Postdoctoral work at the University of California at San Francisco (UCSF), Rich investigated molecular mechanisms that pattern the craniofacial skeleton. In 2001, Rich joined the faculty of the Department of Orthopaedic Surgery at UCSF.

      To study skeletal patterning, Rich has developed an avian transplantation system using quail and duck embryos, which differ considerably in their growth rates and craniofacial anatomy. The experimental approach is simple: embryonic precursor cells destined to form the skeleton are exchanged between quail and duck embryos, making chimeric quck and duail. This causes faster developing quail cells and relatively slower maturing duck cells to interact with one another continuously from the moment they first meet. Also, chimeras are challenged to deal with species-specific differences in size and shape. By looking for donor-induced changes to the formation of bone, cartilage, and other tissues, Rich’s lab has been able to identify molecular mechanisms that pattern the skeleton, and elucidate the role of development in evolution. A long-term goal of Rich’s research is to build a foundation for molecular-based therapies that can induce repair and regeneration of cartilages and bones affected by congenital defects, disease, and injury.

      For more than a decade, Rich has also have been vigorously engaged in issues related to scholarly communications and open access. He served as Chair on both the UCSF (COLASC) and the UC System-wide (UCOLASC) library committees of the Academic Senate, and he led the effort to develop and pass an Open Access Policy for UCSF Faculty. In addition, he helped pass an Open Access Policy at the UC System-wide level and is currently serving on a Presidential Task Force to expand the Open Access Policy to the entire UC System.


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       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Fish JL, Schneider RA. Assessing Species-specific Contributions To Craniofacial Development Using Quail-duck Chimeras. J Vis Exp. 2014; (87).
        View in: PubMed
      2. Young NM, Hu D, Lainoff AJ, Smith FJ, Diaz R, Tucker AS, Trainor PA, Schneider RA, Hallgrímsson B, Marcucio RS. Embryonic bauplans and the developmental origins of facial diversity and constraint. Development. 2014 Mar; 141(5):1059-63.
        View in: PubMed
      3. Fish JL, Sklar RS, Woronowicz KC, Schneider RA. Multiple developmental mechanisms regulate species-specific jaw size. Development. 2014 Feb; 141(3):674-84.
        View in: PubMed
      4. Fish J, Schneider RA. Neural Crest Cells: Evolution, Development and Disease. P. Trainor (editor). Neural Crest-Mediated Tissue Interactions During Craniofacial Development: The Origins of Species-Specific Pattern. 2014; Chapter 6:101-124.
      5. Hall J, Jheon AH, Ealba EL, Eames BF, Butcher KD, Mak SS, Ladher R, Alliston T, Schneider RA. Evolution of a developmental mechanism: Species-specific regulation of the cell cycle and the timing of events during craniofacial osteogenesis. Dev Biol. 2014 Jan 15; 385(2):380-95.
        View in: PubMed
      6. Ealba EL, Schneider RA. A simple PCR-based strategy for estimating species-specific contributions in chimeras and xenografts. Development. 2013 Jul; 140(14):3062-8.
        View in: PubMed
      7. Berthet E, Chen C, Butcher K, Schneider RA, Alliston T, Amirtharajah M. Smad3 binds Scleraxis and Mohawk and regulates tendon matrix organization. J Orthop Res. 2013 Sep; 31(9):1475-83.
        View in: PubMed
      8. Schneider RA. Reshaping Scholarly Communication: Why Faculty are Adopting Institutional Open-Access Policies. Science Editor. 2013; 36(1):20.
      9. Tokita M, Nakayama T, Schneider RA, Agata K. Molecular and cellular changes associated with the evolution of novel jaw muscles in parrots. Proc Biol Sci. 2013 Feb 7; 280(1752):20122319.
        View in: PubMed
      10. Allon AA, Butcher K, Schneider RA, Lotz JC. Structured bilaminar coculture outperforms stem cells and disc cells in a simulated degenerate disc environment. Spine (Phila Pa 1976). 2012 May 1; 37(10):813-8.
        View in: PubMed
      11. Allon AA, Butcher K, Schneider RA, Lotz JC. Structured coculture of mesenchymal stem cells and disc cells enhances differentiation and proliferation. Cells Tissues Organs. 2012; 196(2):99-106.
        View in: PubMed
      12. Cooke ME, Allon AA, Cheng T, Kuo AC, Kim HT, Vail TP, Marcucio RS, Schneider RA, Lotz JC, Alliston T. Structured three-dimensional co-culture of mesenchymal stem cells with chondrocytes promotes chondrogenic differentiation without hypertrophy. Osteoarthritis Cartilage. 2011 Oct; 19(10):1210-8.
        View in: PubMed
      13. Mitgutsch C, Wimmer C, Sánchez-Villagra MR, Hahnloser R, Schneider RA. Timing of ossification in duck, quail, and zebra finch: intraspecific variation, heterochronies, and life history evolution. Zoolog Sci. 2011 Jul; 28(7):491-500.
        View in: PubMed
      14. Solem RC, Eames BF, Tokita M, Schneider RA. Mesenchymal and mechanical mechanisms of secondary cartilage induction. Dev Biol. 2011 Aug 1; 356(1):28-39.
        View in: PubMed
      15. Zheng L, Zhang Y, He P, Kim J, Schneider R, Bronckers AL, Lyaruu DM, DenBesten PK. NBCe1 in mouse and human ameloblasts may be indirectly regulated by fluoride. J Dent Res. 2011 Jun; 90(6):782-7.
        View in: PubMed
      16. Chang JL, Brauer DS, Johnson J, Chen CG, Akil O, Balooch G, Humphrey MB, Chin EN, Porter AE, Butcher K, Ritchie RO, Schneider RA, Lalwani A, Derynck R, Marshall GW, Marshall SJ, Lustig L, Alliston T. Tissue-specific calibration of extracellular matrix material properties by transforming growth factor-ß and Runx2 in bone is required for hearing. EMBO Rep. 2010 Oct; 11(10):765-71.
        View in: PubMed
      17. He P, Zhang Y, Kim SO, Radlanski RJ, Butcher K, Schneider RA, DenBesten PK. Ameloblast differentiation in the human developing tooth: effects of extracellular matrices. Matrix Biol. 2010 Jun; 29(5):411-9.
        View in: PubMed
      18. Tokita M, Schneider RA. Developmental origins of species-specific muscle pattern. Dev Biol. 2009 Jul 15; 331(2):311-25.
        View in: PubMed
      19. Jheon AH, Schneider RA. The cells that fill the bill: neural crest and the evolution of craniofacial development. J Dent Res. 2009 Jan; 88(1):12-21.
        View in: PubMed
      20. Allon A, Schneider RA, Lotz JC. SAS Journal. Co-culture of adult mesenchymal stem cells and nucleus pulposus cells in bilaminar pellets for intervertebral disc regeneration. 2009; 2(3):41-49.
      21. Eames BF, Schneider RA. The genesis of cartilage size and shape during development and evolution. Development. 2008 Dec; 135(23):3947-58.
        View in: PubMed
      22. Merrill AE, Eames BF, Weston SJ, Heath T, Schneider RA. Mesenchyme-dependent BMP signaling directs the timing of mandibular osteogenesis. Development. 2008 Apr; 135(7):1223-34.
        View in: PubMed
      23. Lwigale PY, Schneider RA. Other chimeras: quail-duck and mouse-chick. Methods Cell Biol. 2008; 87:59-74.
        View in: PubMed
      24. Derynck R, Piek E, Schneider RA, Choy L, Alliston T. The TGF-ß Family. Derynck and Miyazono (Editors). Chapter 21: TGF-ß family signalling in mesenchymal differentiation. 2008; 613-666.
      25. Eames BF, Allen N, Young J, Kaplan A, Helms JA, Schneider RA. Skeletogenesis in the swell shark Cephaloscyllium ventriosum. J Anat. 2007 May; 210(5):542-54.
        View in: PubMed
      26. Schneider RA. How to tweak a beak: molecular techniques for studying the evolution of size and shape in Darwin's finches and other birds. Bioessays. 2007 Jan; 29(1):1-6.
        View in: PubMed
      27. Ye L, Le TQ, Zhu L, Butcher K, Schneider RA, Li W, Besten PK. Amelogenins in human developing and mature dental pulp. J Dent Res. 2006 Sep; 85(9):814-8.
        View in: PubMed
      28. Haggstrom AN, Lammer EJ, Schneider RA, Marcucio R, Frieden IJ. Patterns of infantile hemangiomas: new clues to hemangioma pathogenesis and embryonic facial development. Pediatrics. 2006 Mar; 117(3):698-703.
        View in: PubMed
      29. Noden DM, Schneider RA. Neural crest cells and the community of plan for craniofacial development: historical debates and current perspectives. Adv Exp Med Biol. 2006; 589:1-23.
        View in: PubMed
      30. Schneider RA. Developmental mechanisms facilitating the evolution of bills and quills. J Anat. 2005 Nov; 207(5):563-73.
        View in: PubMed
      31. Eames BF, Schneider RA. Quail-duck chimeras reveal spatiotemporal plasticity in molecular and histogenic programs of cranial feather development. Development. 2005 Apr; 132(7):1499-509.
        View in: PubMed
      32. Miclau T, Schneider RA, Eames BF, Helms JA. Bone Regeneration and Repair: Biology and Clinical Applications. Lieberman and Friedlaender (Editors). Common molecular mechanisms regulating fetal bone formation and adult fracture repair. 2005; 45-55.
      33. Radlanski RJ, Renz H, Lajvardi S, Schneider RA. Bone remodeling during prenatal morphogenesis of the human mental foramen. Eur J Oral Sci. 2004 Aug; 112(4):301-10.
        View in: PubMed
      34. Helms JA, Schneider RA. Cranial skeletal biology. Nature. 2003 May 15; 423(6937):326-31.
        View in: PubMed
      35. Schneider RA, Helms JA. The cellular and molecular origins of beak morphology. Science. 2003 Jan 24; 299(5606):565-8.
        View in: PubMed
      36. Radlanski RJ, Renz H, Müller U, Schneider RA, Marcucio RS, Helms JA. Eur J Oral Sci. Prenatal morphogenesis of the human mental foramen. 2002; 6(110):452-9.
      37. Schneider RA, Miclau T, Helms JA. Orthopaedics. Fitzgerald, Kaufer, and Malkani (Editors). Embryology of Bone. 2002; 143-146.
      38. Schneider RA, Hu D, Rubenstein JL, Maden M, Helms JA. Local retinoid signaling coordinates forebrain and facial morphogenesis by maintaining FGF8 and SHH. Development. 2001 Jul; 128(14):2755-67.
        View in: PubMed
      39. Cordero D, Schneider RA, Helms JA. Craniofacial Surgery: Science and Surgical Technique. Lin, Ogle, and Jane (Editors). Morphogenesis of the Face. 2001; 75-83.
      40. Young DL, Schneider RA, Hu D, Helms JA. Genetic and teratogenic approaches to craniofacial development. Crit Rev Oral Biol Med. 2000; 11(3):304-17.
        View in: PubMed
      41. Schneider RA. Neural crest can form cartilages normally derived from mesoderm during development of the avian head skeleton. Dev Biol. 1999 Apr 15; 208(2):441-55.
        View in: PubMed
      42. Schneider RA, Hu D, Helms JA. From head to toe: conservation of molecular signals regulating limb and craniofacial morphogenesis. Cell Tissue Res. 1999 Apr; 296(1):103-9.
        View in: PubMed
      43. Smith KK, Schneider RA. Have gene knockouts caused evolutionary reversals in the mammalian first arch? Bioessays. 1998 Mar; 20(3):245-55.
        View in: PubMed
      44. Schneider, RA Helms, JA. Current Opinion in Orthopedics. Development and regeneration of the musculoskeletal system. 1998; 6(9):20-24.
      45. Coppinger RP, Schneider RA. The Domestic Dog. Serpell J (Editor). Evolution of working dogs. 1995; 21-47.
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