Richard Schneider, PhD
|Address||513 Parnassus Ave, Med Sci|
San Francisco CA 94143
Dr. Rich Schneider grew up in Maplewood, New Jersey. He graduated from Hampshire College in Amherst, Massachusetts in 1991. Following an undergraduate internship at the Smithsonian Institution in Washington, DC, Rich published his first paper, which was on the development and evolution of the skull in wolves and domestic dogs. He then received his Master's Degree in 1994 and his Doctoral Degree in 1998 from Duke University in Durham, North Carolina. Both of his graduate thesis projects focused on skeletal development and evolution in birds and mammals. Rich also studied embryology at the Marine Biological Laboratory in Woods Hole, Massachusetts, and at the Cold Spring Harbor Laboratory on Long Island, New York. For his Postdoctoral work at the University of California at San Francisco (UCSF), Rich investigated molecular mechanisms that pattern the craniofacial skeleton. In 2001, Rich joined the faculty of the Department of Orthopaedic Surgery at UCSF.
To study skeletal patterning, Rich has developed an avian transplantation system using quail and duck embryos, which differ considerably in their growth rates and craniofacial anatomy. The experimental approach is simple: embryonic precursor cells destined to form the skeleton are exchanged between quail and duck embryos. This causes faster developing quail cells and relatively slower maturing duck cells to interact with one another continuously from the moment they first meet. Also, chimeras are challenged to deal with species-specific differences in size and shape. By looking for donor-induced changes to the formation of bone, cartilage, and other tissues, Rich’s lab has been able to identify molecular mechanisms that pattern the skeleton, and elucidate the role of development in evolution. A long-term goal of Rich’s research is to build a foundation for molecular-based therapies that can induce repair and regeneration of cartilages and bones affected by congenital defects, disease, and injury.
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