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    Roland Krug, PhD

    TitleAssistant Professor
    SchoolUCSF School of Medicine
    DepartmentRadiology
    Address185 Berry Street
    San Francisco CA 94143
    Phone415-353-4945
    vCardDownload vCard

      Collapse Biography 
      Collapse Education and Training
      University of California, San FranciscoPostdoctoral StudiesGraduate Division
      Collapse Awards and Honors
      Journal of Magnetic Resonance Imaging2015Cover Image "Variable flip angle three-dimensional fast spin-echo sequence"
      Magnetic Resonance in Medicine2014Editor's Pick: "Bone marrow fat quantification in the presence of trabecular bone"
      Radiological Society of North America2012RSNA Trainee Research Prize for research project
      International Society of Magnetic Resonance in Medicine2012Magna Cum Laude Merit Award
      German National Research Foundation2000Graduate Research Fellowship

      Collapse Overview 
      Collapse Overview
      Roland Krug, PhD, is an Assistant Professor in the Musculoskeletal Quantitative Imaging Research Group. He is Director of Krug Laboratory at the University of California, San Francisco China Basin, and he is an Assistant Professor in Orthopedic Surgery at UCSF. Dr. Krug obtained his PhD in Medical Physics in 2003 from the German Cancer Research Center in Heidelberg, Germany. Followed by a three-year postgraduate training as a postdoctoral fellow at UCSF in 2006. In July 2010, Dr. Krug accepted a position as Assistant Professor in Residence in the MQIR Group at UCSF China Basin.

      Dr. Krug’s research interests include technical development of Magnetic Resonance Imaging and Spectroscopy methods and advanced digital imaging processing algorithms. In particular, his laboratory develops new MR pulse sequences and image analysis methods for in vivo, high-resolution MRI at high and ultra-high strengths (7 Tesla). His clinical focus is the assessment of musculoskeletal health. In particular he is interested in bone and bone marrow health, muscle quality, ligament, tendon and meniscus imaging as well as MR imaging in the presence of metal hardware.

      Dr. Krug serves as a reviewer for 13 scientific journals, and he serves on 4 UCSF departmental committees. Dr. Krug has more than 30 peer-reviewed articles published in the highest ranking journals in the field.

      Expertise:
      Musculoskeletal Imaging

      Specialty:
      Advanced pulse sequence development for high field MR imaging and MR spectroscopy.

      Professional Interests:
      High-resolution MRI of trabecular and cortical bone, MR fat quantification based on Dixon techniques, image analysis techniques of trabecular bone microstructure. ultra-short-TE (UTE) MRI of bone, tendons and ligaments, high-intensity focused ultra-sound (HIFU) applications for bone ablation (temperature mapping of bone using UTE).

      Education and Training:
      • Undergraduate: University of Heidelberg Germany - Physics
      • Doctor of Philosophy: German Cancer Research Center, Heidelberg - Medical Physics
      • Postdoctoral Fellowship: University of California, San Francisco - Radiology

      Collapse Interests
      My main research interest relates to the assessment of lower back pain as well as bone health and fracture risk. In particular, we develop methods to assess spine health (such as spinal endplate, disk and marrow changes) as well as bone and marrow quality in the hip., We use advanced MRI techniques such as MR fat quantification imaging based on Dixon, ultra-short-echo time (UTE) and high-intensity focused ultra-sound (HIFU).

      Collapse ORNG Applications 
      Collapse Websites
      Collapse Awarded Grants
      Collapse Featured Publications

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Ozhinsky E, Han M, Bucknor M, Krug R, Rieke V. T2-based temperature monitoring in bone marrow for MR-guided focused ultrasound. J Ther Ultrasound. 2016; 4:26. PMID: 27882240.
        View in: PubMed
      2. Krug R, Do L, Rieke V, Wilson MW, Saeed M. Evaluation of MRI protocols for the assessment of lumbar facet joints after MR-guided focused ultrasound treatment. J Ther Ultrasound. 2016; 4:14. PMID: 27054038.
        View in: PubMed
      3. Saeed M, Krug R, Do L, Hetts SW, Wilson MW. Renal ablation using magnetic resonance-guided high intensity focused ultrasound: Magnetic resonance imaging and histopathology assessment. World J Radiol. 2016 Mar 28; 8(3):298-307. PMID: 27027736.
        View in: PubMed
      4. Nardo L, Carballido-Gamio J, Tang S, Lai A, Krug R. Quantitative assessment of morphology, T1?, and T2 of shoulder cartilage using MRI. Eur Radiol. 2016 Mar 18. PMID: 26993651.
        View in: PubMed
      5. Larson PE, Han M, Krug R, Jakary A, Nelson SJ, Vigneron DB, Henry RG, McKinnon G, Kelley DA. Ultrashort echo time and zero echo time MRI at 7T. MAGMA. 2016 Jun; 29(3):359-70. PMID: 26702940.
        View in: PubMed
      6. Nardo L, Han M, Kretzschmar M, Guindani M, Koch K, Vail T, Krug R, Link TM. Erratum to: Metal artifact suppression at the hip: diagnostic performance at 3.0 T versus 1.5 Tesla. Skeletal Radiol. 2015 Nov; 44(11):1617. PMID: 26298104.
        View in: PubMed
      7. Han M, Rieke V, Scott SJ, Ozhinsky E, Salgaonkar VA, Jones PD, Larson PE, Diederich CJ, Krug R. Quantifying temperature-dependent T1 changes in cortical bone using ultrashort echo-time MRI. Magn Reson Med. 2015 Dec; 74(6):1548-55. PMID: 26390357.
        View in: PubMed
      8. Saeed M, Van TA, Krug R, Hetts SW, Wilson MW. Cardiac MR imaging: current status and future direction. Cardiovasc Diagn Ther. 2015 Aug; 5(4):290-310. PMID: 26331113; PMCID: PMC4536478.
      9. Nardo L, Han M, Kretschmar M, Guindani M, Koch K, Vail T, Krug R, Link TM. Metal artifact suppression at the hip: diagnostic performance at 3.0 T versus 1.5 Tesla. Skeletal Radiol. 2015 Nov; 44(11):1609-16. PMID: 26201676.
        View in: PubMed
      10. Do L, Wilson MW, Krug R, Hetts SW, Saeed M. MRI monitoring of function, perfusion and viability in microembolized moderately ischemic myocardium. Int J Cardiovasc Imaging. 2015 Aug; 31(6):1179-90. PMID: 25951916.
        View in: PubMed
      11. Lee S, Lucas RM, Lansdown DA, Nardo L, Lai A, Link TM, Krug R, Ma CB. Magnetic resonance rotator cuff fat fraction and its relationship with tendon tear severity and subject characteristics. J Shoulder Elbow Surg. 2015 Sep; 24(9):1442-51. PMID: 25819731.
        View in: PubMed
      12. Kretzschmar M, Nardo L, Han MM, Heilmeier U, Sam C, Joseph GB, Koch KM, Krug R, Link TM. Metal artefact suppression at 3 T MRI: comparison of MAVRIC-SL with conventional fast spin echo sequences in patients with Hip joint arthroplasty. Eur Radiol. 2015 Aug; 25(8):2403-11. PMID: 25680728.
        View in: PubMed
      13. Gee CS, Nguyen JT, Marquez CJ, Heunis J, Lai A, Wyatt C, Han M, Kazakia G, Burghardt AJ, Karampinos DC, Carballido-Gamio J, Krug R. Validation of bone marrow fat quantification in the presence of trabecular bone using MRI. J Magn Reson Imaging. 2015 Aug; 42(2):539-44. PMID: 25425074; PMCID: PMC4442769 [Available on 08/01/16].
      14. Fields AJ, Han M, Krug R, Lotz JC. Cartilaginous end plates: Quantitative MR imaging with very short echo times-orientation dependence and correlation with biochemical composition. Radiology. 2015 Feb; 274(2):482-9. PMID: 25302832; PMCID: PMC4314292 [Available on 02/01/16].
      15. Han M, Chiba K, Banerjee S, Carballido-Gamio J, Krug R. Variable flip angle three-dimensional fast spin-echo sequence combined with outer volume suppression for imaging trabecular bone structure of the proximal femur. J Magn Reson Imaging. 2015 May; 41(5):1300-10. PMID: 24956149; PMCID: PMC4275424 [Available on 05/01/16].
      16. Liebl H, Heilmeier U, Lee S, Nardo L, Patsch J, Schuppert C, Han M, Rondak IC, Banerjee S, Koch K, Link TM, Krug R. In vitro assessment of knee MRI in the presence of metal implants comparing MAVRIC-SL and conventional fast spin echo sequences at 1.5 and 3 T field strength. J Magn Reson Imaging. 2015 May; 41(5):1291-9. PMID: 24912802; PMCID: PMC4297744 [Available on 05/01/16].
      17. Han M, Larson PE, Liu J, Krug R. Depiction of achilles tendon microstructure in vivo using high-resolution 3-dimensional ultrashort echo-time magnetic resonance imaging at 7 T. Invest Radiol. 2014 May; 49(5):339-45. PMID: 24500089; PMCID: PMC4143127.
      18. Karampinos DC, Melkus G, Baum T, Bauer JS, Rummeny EJ, Krug R. Bone marrow fat quantification in the presence of trabecular bone: initial comparison between water-fat imaging and single-voxel MRS. Magn Reson Med. 2014 Mar; 71(3):1158-65. PMID: 23657998; PMCID: PMC3759615.
      19. Nardo L, Karampinos DC, Lansdown DA, Carballido-Gamio J, Lee S, Maroldi R, Ma CB, Link TM, Krug R. Quantitative assessment of fat infiltration in the rotator cuff muscles using water-fat MRI. J Magn Reson Imaging. 2014 May; 39(5):1178-85. PMID: 24115490; PMCID: PMC3964138.
      20. Alizai H, Nardo L, Karampinos DC, Joseph GB, Yap SP, Baum T, Krug R, Majumdar S, Link TM. Comparison of clinical semi-quantitative assessment of muscle fat infiltration with quantitative assessment using chemical shift-based water/fat separation in MR studies of the calf of post-menopausal women. Eur Radiol. 2012 Jul; 22(7):1592-600. PMID: 22411305; PMCID: PMC3584153.
      21. Krug R, Larson PE, Wang C, Burghardt AJ, Kelley DA, Link TM, Zhang X, Vigneron DB, Majumdar S. Ultrashort echo time MRI of cortical bone at 7 tesla field strength: a feasibility study. J Magn Reson Imaging. 2011 Sep; 34(3):691-5. PMID: 21769960; PMCID: PMC3197976.
      22. Carballido-Gamio J, Folkesson J, Karampinos DC, Baum T, Link TM, Majumdar S, Krug R. Generation of an atlas of the proximal femur and its application to trabecular bone analysis. Magn Reson Med. 2011 Oct; 66(4):1181-91. PMID: 21432904; PMCID: PMC3596104.
      23. Folkesson J, Goldenstein J, Carballido-Gamio J, Kazakia G, Burghardt AJ, Rodriguez A, Krug R, de Papp AE, Link TM, Majumdar S. Longitudinal evaluation of the effects of alendronate on MRI bone microarchitecture in postmenopausal osteopenic women. Bone. 2011 Mar 1; 48(3):611-21. PMID: 21059422; PMCID: PMC4461063.
      24. Krug R, Burghardt AJ, Majumdar S, Link TM. High-resolution imaging techniques for the assessment of osteoporosis. Radiol Clin North Am. 2010 May; 48(3):601-21. PMID: 20609895; PMCID: PMC2901255.
      25. Ristow O, Stehling C, Krug R, Steinbach L, Sabo G, Ambekar A, Huber M, Link TM. Isotropic 3-dimensional fast spin echo imaging versus standard 2-dimensional imaging at 3.0 T of the knee: artificial cartilage and meniscal lesions in a porcine model. J Comput Assist Tomogr. 2010 Mar-Apr; 34(2):260-9. PMID: 20351518.
        View in: PubMed
      26. Stehling C, Liebl H, Krug R, Lane NE, Nevitt MC, Lynch J, McCulloch CE, Link TM. Patellar cartilage: T2 values and morphologic abnormalities at 3.0-T MR imaging in relation to physical activity in asymptomatic subjects from the osteoarthritis initiative. Radiology. 2010 Feb; 254(2):509-20. PMID: 20019141; PMCID: PMC2809928.
      27. Krug R, Stehling C, Kelley DA, Majumdar S, Link TM. Imaging of the musculoskeletal system in vivo using ultra-high field magnetic resonance at 7 T. Invest Radiol. 2009 Sep; 44(9):613-8. PMID: 19652609.
        View in: PubMed
      28. Wu B, Wang C, Krug R, Kelley DA, Xu D, Pang Y, Banerjee S, Vigneron DB, Nelson SJ, Majumdar S, Zhang X. 7T human spine imaging arrays with adjustable inductive decoupling. IEEE Trans Biomed Eng. 2010 Feb; 57(2):397-403. PMID: 19709956; PMCID: PMC2834655.
      29. Folkesson J, Krug R, Goldenstein J, Issever AS, Fang C, Link TM, Majumdar S. Evaluation of correction methods for coil-induced intensity inhomogeneities and their influence on trabecular bone structure parameters from MR images. Med Phys. 2009 Apr; 36(4):1267-74. PMID: 19472635.
        View in: PubMed
      30. Zhao J, Krug R, Xu D, Lu Y, Link TM. MRI of the spine: image quality and normal-neoplastic bone marrow contrast at 3 T versus 1.5 T. AJR Am J Roentgenol. 2009 Apr; 192(4):873-80. PMID: 19304689.
        View in: PubMed
      31. Stahl R, Krug R, Kelley DA, Zuo J, Ma CB, Majumdar S, Link TM. Assessment of cartilage-dedicated sequences at ultra-high-field MRI: comparison of imaging performance and diagnostic confidence between 3.0 and 7.0 T with respect to osteoarthritis-induced changes at the knee joint. Skeletal Radiol. 2009 Aug; 38(8):771-83. PMID: 19294379; PMCID: PMC2704950.
      32. Carballido-Gamio J, Krug R, Huber MB, Hyun B, Eckstein F, Majumdar S, Link TM. Geodesic topological analysis of trabecular bone microarchitecture from high-spatial resolution magnetic resonance images. Magn Reson Med. 2009 Feb; 61(2):448-56. PMID: 19161163; PMCID: PMC4445730.
      33. Ristow O, Steinbach L, Sabo G, Krug R, Huber M, Rauscher I, Ma B, Link TM. Isotropic 3D fast spin-echo imaging versus standard 2D imaging at 3.0 T of the knee--image quality and diagnostic performance. Eur Radiol. 2009 May; 19(5):1263-72. PMID: 19137309.
        View in: PubMed
      34. Bauer JS, Monetti R, Krug R, Matsuura M, Mueller D, Eckstein F, Rummeny EJ, Lochmueller EM, Raeth CW, Link TM. Advances of 3T MR imaging in visualizing trabecular bone structure of the calcaneus are partially SNR-independent: analysis using simulated noise in relation to micro-CT, 1.5T MRI, and biomechanical strength. J Magn Reson Imaging. 2009 Jan; 29(1):132-40. PMID: 19097112.
        View in: PubMed
      35. Carballido-Gamio J, Link TM, Li X, Han ET, Krug R, Ries MD, Majumdar S. Feasibility and reproducibility of relaxometry, morphometric, and geometrical measurements of the hip joint with magnetic resonance imaging at 3T. J Magn Reson Imaging. 2008 Jul; 28(1):227-35. PMID: 18581346.
        View in: PubMed
      36. Stahl R, Luke A, Ma CB, Krug R, Steinbach L, Majumdar S, Link TM. Prevalence of pathologic findings in asymptomatic knees of marathon runners before and after a competition in comparison with physically active subjects-a 3.0 T magnetic resonance imaging study. Skeletal Radiol. 2008 Jul; 37(7):627-38. PMID: 18463868.
        View in: PubMed
      37. Kazakia GJ, Hyun B, Burghardt AJ, Krug R, Newitt DC, de Papp AE, Link TM, Majumdar S. In vivo determination of bone structure in postmenopausal women: a comparison of HR-pQCT and high-field MR imaging. J Bone Miner Res. 2008 Apr; 23(4):463-74. PMID: 18052756.
        View in: PubMed
      38. Krug R, Carballido-Gamio J, Banerjee S, Burghardt AJ, Link TM, Majumdar S. In vivo ultra-high-field magnetic resonance imaging of trabecular bone microarchitecture at 7 T. J Magn Reson Imaging. 2008 Apr; 27(4):854-9. PMID: 18383263.
        View in: PubMed
      39. Banerjee S, Krug R, Carballido-Gamio J, Kelley DA, Xu D, Vigneron DB, Majumdar S. Rapid in vivo musculoskeletal MR with parallel imaging at 7T. Magn Reson Med. 2008 Mar; 59(3):655-60. PMID: 18224700.
        View in: PubMed
      40. Krug R, Carballido-Gamio J, Banerjee S, Stahl R, Carvajal L, Xu D, Vigneron D, Kelley DA, Link TM, Majumdar S. In vivo bone and cartilage MRI using fully-balanced steady-state free-precession at 7 tesla. Magn Reson Med. 2007 Dec; 58(6):1294-8. PMID: 17957777.
        View in: PubMed
      41. Krug R, Carballido-Gamio J, Burghardt AJ, Kazakia G, Hyun BH, Jobke B, Banerjee S, Huber M, Link TM, Majumdar S. Assessment of trabecular bone structure comparing magnetic resonance imaging at 3 Tesla with high-resolution peripheral quantitative computed tomography ex vivo and in vivo. Osteoporos Int. 2008 May; 19(5):653-61. PMID: 17992467.
        View in: PubMed
      42. Blumenfeld J, Carballido-Gamio J, Krug R, Blezek DJ, Hancu I, Majumdar S. Automatic prospective registration of high-resolution trabecular bone images of the tibia. Ann Biomed Eng. 2007 Nov; 35(11):1924-31. PMID: 17705036.
        View in: PubMed
      43. Bauer JS, Banerjee S, Henning TD, Krug R, Majumdar S, Link TM. Fast high-spatial-resolution MRI of the ankle with parallel imaging using GRAPPA at 3 T. AJR Am J Roentgenol. 2007 Jul; 189(1):240-5. PMID: 17579177.
        View in: PubMed
      44. Krug R, Carballido-Gamio J, Burghardt AJ, Haase S, Sedat JW, Moss WC, Majumdar S. Wavelet-based characterization of vertebral trabecular bone structure from magnetic resonance images at 3 T compared with micro-computed tomographic measurements. Magn Reson Imaging. 2007 Apr; 25(3):392-8. PMID: 17371730.
        View in: PubMed
      45. Bauer JS, Krause SJ, Ross CJ, Krug R, Carballido-Gamio J, Ozhinsky E, Majumdar S, Link TM. Volumetric cartilage measurements of porcine knee at 1.5-T and 3.0-T MR imaging: evaluation of precision and accuracy. Radiology. 2006 Nov; 241(2):399-406. PMID: 17057067.
        View in: PubMed
      46. Krug R, Han ET, Banerjee S, Majumdar S. Fully balanced steady-state 3D-spin-echo (bSSSE) imaging at 3 Tesla. Magn Reson Med. 2006 Nov; 56(5):1033-40. PMID: 16986110.
        View in: PubMed
      47. Krug R, Banerjee S, Han ET, Newitt DC, Link TM, Majumdar S. Feasibility of in vivo structural analysis of high-resolution magnetic resonance images of the proximal femur. Osteoporos Int. 2005 Nov; 16(11):1307-14. PMID: 15999292.
        View in: PubMed
      48. Banerjee S, Han ET, Krug R, Newitt DC, Majumdar S. Application of refocused steady-state free-precession methods at 1.5 and 3 T to in vivo high-resolution MRI of trabecular bone: simulations and experiments. J Magn Reson Imaging. 2005 Jun; 21(6):818-25. PMID: 15906346.
        View in: PubMed
      49. Krug R, Carballido-Gamio J, Burghardt A, Haase S, Sedat J, Moss W, Majumdar S. Wavelet Based Characterization of Vertebral Trabecular Bone Structure from MR Images of Specimen at 3 Tesla Compared to MicroCT Measurements. Conf Proc IEEE Eng Med Biol Soc. 2005; 7:7040-3. PMID: 17281896.
        View in: PubMed
      50. Krug R, Boese JM, Schad LR. Determination of aortic compliance from magnetic resonance images using an automatic active contour model. Phys Med Biol. 2003 Aug 7; 48(15):2391-404. PMID: 12953905.
        View in: PubMed
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