Yadong Huang, MD, PhD

Title(s)Professor, Neurology
SchoolSchool of Medicine
Address35 Medical Center Way, #1038
San Francisco CA 94143
Phone415-734-2511
ORCID ORCID Icon0000-0002-5871-4589 Additional info
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoClinical Fellowship

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Decoding the Multifactorial Etiology of Neural Network Dysfunction in Alzheimer's Disease
    NIH P01AG073082Aug 15, 2021 - Jul 31, 2026
    Role: Co-Principal Investigator
    Neuronal ApoE Drives Selective Neurodegeneration in Alzheimer's Disease
    NIH R01AG071697Aug 1, 2021 - May 31, 2026
    Role: Principal Investigator
    Study the Protective Roles of ApoE2 in Alzheimer's Disease Using Reprogrammed Isogenic Cells
    NIH R01AG065540May 1, 2020 - Mar 31, 2025
    Role: Principal Investigator
    ApoE Genotype-Directed Drug Repositioning and Combination Therapy for Alzheimer's Disease
    NIH R01AG057683Sep 15, 2017 - May 31, 2022
    Role: Principal Investigator
    Study ApoE4's Effects on Hippocampal Network Activity in Alzheimer's Disease
    NIH R01AG055682Aug 15, 2017 - Apr 30, 2022
    Role: Principal Investigator
    Modeling Alzheimer?s disease using directly reprogrammed isogenic neural cells
    NIH R01AG056305Aug 1, 2017 - Apr 30, 2022
    Role: Co-Principal Investigator
    Roles of ApoE4 in Brain Aging and Alzheimer's Disease
    NIH RF1AG055421Apr 15, 2017 - Mar 31, 2022
    Role: Principal Investigator
    Apolipoprotein E in Alzheimer's Disease: Molecular Mechanism
    NIH R01AG048017Apr 15, 2015 - Mar 31, 2020
    Role: Principal Investigator
    Studying Alzheimer's Disease Using Human iPS Cells
    NIH RF1AG048030Sep 1, 2014 - Jun 30, 2019
    Role: Principal Investigator
    Optogenetic Study of ApoE4-Related Alzheimers Disease
    NIH RF1AG047655Jun 15, 2014 - May 31, 2019
    Role: Principal Investigator
    Frontotemporal Dementia Induced Pluripotent Stem Cell Consortium
    NIH R01NS079725Sep 30, 2013 - Jun 30, 2017
    Role: Principal Investigator
    New Approaches to Dementia Heterogeneity
    NIH P50AG023501Apr 1, 2004 - Mar 31, 2019
    Role: Co-Investigator
    Proteinopathies of the Aging Central Nervous System
    NIH P01AG022074Jun 15, 2003 - Nov 30, 2013
    Role: Co-Investigator
    APOE EXPRESSION LEVEL MODULATES VLDL METABOLISM
    NIH R01HL064162May 1, 2000 - Apr 30, 2005
    Role: Principal Investigator
    Regulation of Apolipoprotein Synthesis
    NIH R01HL037063Jul 1, 1986 - Mar 31, 2005
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Apolipoprotein E and Alzheimer's Disease: Findings, Hypotheses, and Potential Mechanisms. Annu Rev Pathol. 2022 01 24; 17:73-99. Koutsodendris N, Nelson MR, Rao A, Huang Y. PMID: 34460318.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    2. Early Hippocampal Sharp-Wave Ripple Deficits Predict Later Learning and Memory Impairments in an Alzheimer's Disease Mouse Model. Cell Rep. 2019 11 19; 29(8):2123-2133.e4. Jones EA, Gillespie AK, Yoon SY, Frank LM, Huang Y. PMID: 31747587; PMCID: PMC7437815.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    3. An Alzheimer's-disease-protective APOE mutation. Nat Med. 2019 11; 25(11):1648-1649. Zalocusky KA, Nelson MR, Huang Y. PMID: 31686033.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    4. Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer's disease. Mol Neurodegener. 2019 06 11; 14(1):24. Najm R, Jones EA, Huang Y. PMID: 31186040; PMCID: PMC6558779.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    5. Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector. Nat Med. 2018 05; 24(5):647-657. Wang C, Najm R, Xu Q, Jeong DE, Walker D, Balestra ME, Yoon SY, Yuan H, Li G, Miller ZA, Miller BL, Malloy MJ, Huang Y. PMID: 29632371; PMCID: PMC5948154.
      View in: PubMed   Mentions: 155     Fields:    Translation:HumansCells
    6. Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case-control study. PLoS Med. 2017 Mar; 14(3):e1002272. Steele NZ, Carr JS, Bonham LW, Geier EG, Damotte V, Miller ZA, Desikan RS, Boehme KL, Mukherjee S, Crane PK, Kauwe JS, Kramer JH, Miller BL, Coppola G, Hollenbach JA, Huang Y, Yokoyama JS. PMID: 28350795; PMCID: PMC5369701.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    7. Approaching Alzheimer's disease from a network level. Oncotarget. 2017 Feb 07; 8(6):9003-9004. Gillespie AK, Jones EA, Huang Y. PMID: 28099927; PMCID: PMC5354704.
      View in: PubMed   Mentions:    Fields:    
    8. Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability. Stem Cell Reports. 2016 09 13; 7(3):325-340. Silva MC, Cheng C, Mair W, Almeida S, Fong H, Biswas MHU, Zhang Z, Huang Y, Temple S, Coppola G, Geschwind DH, Karydas A, Miller BL, Kosik KS, Gao FB, Steen JA, Haggarty SJ. PMID: 27594585; PMCID: PMC5032560.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    9. Apolipoprotein E4 Causes Age-Dependent Disruption of Slow Gamma Oscillations during Hippocampal Sharp-Wave Ripples. Neuron. 2016 05 18; 90(4):740-51. Gillespie AK, Jones EA, Lin YH, Karlsson MP, Kay K, Yoon SY, Tong LM, Nova P, Carr JS, Frank LM, Huang Y. PMID: 27161522; PMCID: PMC5097044.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    10. Pharmacological Reprogramming of Fibroblasts into Neural Stem Cells by Signaling-Directed Transcriptional Activation. Cell Stem Cell. 2016 05 05; 18(5):653-67. Zhang M, Lin YH, Sun YJ, Zhu S, Zheng J, Liu K, Cao N, Li K, Huang Y, Ding S. PMID: 27133794; PMCID: PMC4864020.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    11. Enhancing GABA Signaling during Middle Adulthood Prevents Age-Dependent GABAergic Interneuron Decline and Learning and Memory Deficits in ApoE4 Mice. J Neurosci. 2016 Feb 17; 36(7):2316-22. Tong LM, Yoon SY, Andrews-Zwilling Y, Yang A, Lin V, Lei H, Huang Y. PMID: 26888940; PMCID: PMC4756160.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    12. Direct Reprogramming of RESTing Astrocytes. Cell Stem Cell. 2015 Jul 02; 17(1):1-3. Wang C, Fong H, Huang Y. PMID: 26140600.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    13. Stem cell therapy for Alzheimer's disease and related disorders: current status and future perspectives. Exp Mol Med. 2015 Mar 13; 47:e151. Tong LM, Fong H, Huang Y. PMID: 25766620; PMCID: PMC4351411.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    14. Apolipoprotein E4 produced in GABAergic interneurons causes learning and memory deficits in mice. J Neurosci. 2014 Oct 15; 34(42):14069-78. Knoferle J, Yoon SY, Walker D, Leung L, Gillespie AK, Tong LM, Bien-Ly N, Huang Y. PMID: 25319703; PMCID: PMC4198545.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    15. Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases. Neurobiol Dis. 2014 Dec; 72 Pt A:3-12. Huang Y, Mahley RW. PMID: 25173806; PMCID: PMC4253862.
      View in: PubMed   Mentions: 287     Fields:    Translation:HumansAnimalsCells
    16. Inhibitory interneuron progenitor transplantation restores normal learning and memory in ApoE4 knock-in mice without or with Aβ accumulation. J Neurosci. 2014 Jul 16; 34(29):9506-15. Tong LM, Djukic B, Arnold C, Gillespie AK, Yoon SY, Wang MM, Zhang O, Knoferle J, Rubenstein JL, Alvarez-Buylla A, Huang Y. PMID: 25031394; PMCID: PMC4099537.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    17. Genetic correction of tauopathy phenotypes in neurons derived from human induced pluripotent stem cells. Stem Cell Reports. 2013; 1(3):226-34. Fong H, Wang C, Knoferle J, Walker D, Balestra ME, Tong LM, Leung L, Ring KL, Seeley WW, Karydas A, Kshirsagar MA, Boxer AL, Kosik KS, Miller BL, Huang Y. PMID: 24319659; PMCID: PMC3849235.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCells
    18. Greater medial temporal hypometabolism and lower cortical amyloid burden in ApoE4-positive AD patients. J Neurol Neurosurg Psychiatry. 2014 Mar; 85(3):266-73. Lehmann M, Ghosh PM, Madison C, Karydas A, Coppola G, O'Neil JP, Huang Y, Miller BL, Jagust WJ, Rabinovici GD. PMID: 23965289; PMCID: PMC3946299.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    19. Cellular source-specific effects of apolipoprotein (apo) E4 on dendrite arborization and dendritic spine development. PLoS One. 2013; 8(3):e59478. Jain S, Yoon SY, Leung L, Knoferle J, Huang Y. PMID: 23527202; PMCID: PMC3602301.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    20. Apolipoprotein E4 causes age- and sex-dependent impairments of hilar GABAergic interneurons and learning and memory deficits in mice. PLoS One. 2012; 7(12):e53569. Leung L, Andrews-Zwilling Y, Yoon SY, Jain S, Ring K, Dai J, Wang MM, Tong L, Walker D, Huang Y. PMID: 23300939; PMCID: PMC3534053.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    21. Apolipoprotein e sets the stage: response to injury triggers neuropathology. Neuron. 2012 Dec 06; 76(5):871-85. Mahley RW, Huang Y. PMID: 23217737; PMCID: PMC4891195.
      View in: PubMed   Mentions: 173     Fields:    Translation:HumansAnimals
    22. Small-molecule structure correctors target abnormal protein structure and function: structure corrector rescue of apolipoprotein E4-associated neuropathology. J Med Chem. 2012 Nov 08; 55(21):8997-9008. Mahley RW, Huang Y. PMID: 23013167; PMCID: PMC4904786.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    23. Arf4 determines dentate gyrus-mediated pattern separation by regulating dendritic spine development. PLoS One. 2012; 7(9):e46340. Jain S, Yoon SY, Zhu L, Brodbeck J, Dai J, Walker D, Huang Y.
    24. Arf4 determines dentate gyrus-mediated pattern separation by regulating dendritic spine development. PLoS One. 2012; 7(9):e46340. Jain S, Yoon SY, Zhu L, Brodbeck J, Dai J, Walker D, Huang Y. PMID: 23050017; PMCID: PMC3457985.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    25. Hilar GABAergic interneuron activity controls spatial learning and memory retrieval. PLoS One. 2012; 7(7):e40555. Andrews-Zwilling Y, Gillespie AK, Kravitz AV, Nelson AB, Devidze N, Lo I, Yoon SY, Bien-Ly N, Ring K, Zwilling D, Potter GB, Rubenstein JL, Kreitzer AC, Huang Y. PMID: 22792368; PMCID: PMC3390383.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    26. Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor. Cell Stem Cell. 2012 Jul 06; 11(1):100-9. Ring KL, Tong LM, Balestra ME, Javier R, Andrews-Zwilling Y, Li G, Walker D, Zhang WR, Kreitzer AC, Huang Y. PMID: 22683203; PMCID: PMC3399516.
      View in: PubMed   Mentions: 272     Fields:    Translation:HumansAnimalsCells
    27. ApoE and TDP-43 neuropathology in two siblings with familial FTLD-motor neuron disease. Neurocase. 2013; 19(3):295-301. Vossel KA, Bien-Ly N, Bernardo A, Rascovsky K, Karydas A, Rabinovici GD, Sidhu M, Huang EJ, Miller BL, Huang Y, Seeley WW. PMID: 22512241; PMCID: PMC3655113.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    28. Reducing human apolipoprotein E levels attenuates age-dependent Aβ accumulation in mutant human amyloid precursor protein transgenic mice. J Neurosci. 2012 Apr 04; 32(14):4803-11. Bien-Ly N, Gillespie AK, Walker D, Yoon SY, Huang Y. PMID: 22492035; PMCID: PMC3433173.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimals
    29. Alzheimer mechanisms and therapeutic strategies. Cell. 2012 Mar 16; 148(6):1204-22. Huang Y, Mucke L. PMID: 22424230; PMCID: PMC3319071.
      View in: PubMed   Mentions: 721     Fields:    
    30. Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons. J Biol Chem. 2012 Feb 17; 287(8):5253-66. Chen HK, Liu Z, Meyer-Franke A, Brodbeck J, Miranda RD, McGuire JG, Pleiss MA, Ji ZS, Balestra ME, Walker DW, Xu Q, Jeong DE, Budamagunta MS, Voss JC, Freedman SB, Weisgraber KH, Huang Y, Mahley RW. PMID: 22158868; PMCID: PMC3285306.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCells
    31. Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse models. Biochem Soc Trans. 2011 Aug; 39(4):924-32. Huang Y. PMID: 21787325.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    32. Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration. Cell. 2011 Jun 10; 145(6):863-74. Zwilling D, Huang SY, Sathyasaikumar KV, Notarangelo FM, Guidetti P, Wu HQ, Lee J, Truong J, Andrews-Zwilling Y, Hsieh EW, Louie JY, Wu T, Scearce-Levie K, Patrick C, Adame A, Giorgini F, Moussaoui S, Laue G, Rassoulpour A, Flik G, Huang Y, Muchowski JM, Masliah E, Schwarcz R, Muchowski PJ. PMID: 21640374; PMCID: PMC3118409.
      View in: PubMed   Mentions: 230     Fields:    Translation:HumansAnimals
    33. Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors. J Biol Chem. 2011 May 13; 286(19):17217-26. Brodbeck J, McGuire J, Liu Z, Meyer-Franke A, Balestra ME, Jeong DE, Pleiss M, McComas C, Hess F, Witter D, Peterson S, Childers M, Goulet M, Liverton N, Hargreaves R, Freedman S, Weisgraber KH, Mahley RW, Huang Y. PMID: 21454574; PMCID: PMC3089564.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    34. C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-beta (Abeta) and acts in concert with Abeta to elicit neuronal and behavioral deficits in mice. Proc Natl Acad Sci U S A. 2011 Mar 08; 108(10):4236-41. Bien-Ly N, Andrews-Zwilling Y, Xu Q, Bernardo A, Wang C, Huang Y. PMID: 21368138; PMCID: PMC3053957.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    35. Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease. J Biol Chem. 2011 Feb 18; 286(7):5215-21. Chen HK, Ji ZS, Dodson SE, Miranda RD, Rosenblum CI, Reynolds IJ, Freedman SB, Weisgraber KH, Huang Y, Mahley RW. PMID: 21118811; PMCID: PMC3037634.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimalsCells
    36. Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice. J Neurosci. 2010 Oct 13; 30(41):13707-17. Andrews-Zwilling Y, Bien-Ly N, Xu Q, Li G, Bernardo A, Yoon SY, Zwilling D, Yan TX, Chen L, Huang Y. PMID: 20943911; PMCID: PMC2988475.
      View in: PubMed   Mentions: 186     Fields:    Translation:AnimalsCells
    37. Mechanisms linking apolipoprotein E isoforms with cardiovascular and neurological diseases. Curr Opin Lipidol. 2010 Aug; 21(4):337-45. Huang Y. PMID: 20531185.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimals
    38. Cellular source of apolipoprotein E4 determines neuronal susceptibility to excitotoxic injury in transgenic mice. Am J Pathol. 2010 Aug; 177(2):563-9. Buttini M, Masliah E, Yu GQ, Palop JJ, Chang S, Bernardo A, Lin C, Wyss-Coray T, Huang Y, Mucke L. PMID: 20595630; PMCID: PMC2913361.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    39. Abeta-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease. Trends Mol Med. 2010 Jun; 16(6):287-94. Huang Y. PMID: 20537952.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    40. GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice. Cell Stem Cell. 2009 Dec 04; 5(6):634-45. Li G, Bien-Ly N, Andrews-Zwilling Y, Xu Q, Bernardo A, Ring K, Halabisky B, Deng C, Mahley RW, Huang Y. PMID: 19951691; PMCID: PMC2992822.
      View in: PubMed   Mentions: 131     Fields:    Translation:HumansAnimalsCells
    41. Bioactive TGF-beta can associate with lipoproteins and is enriched in those containing apolipoprotein E3. J Neurochem. 2009 Aug; 110(4):1254-62. Tesseur I, Zhang H, Brecht W, Corn J, Gong JS, Yanagisawa K, Michikawa M, Weisgraber K, Huang Y, Wyss-Coray T. PMID: 19549280; PMCID: PMC2915937.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    42. Alzheimer disease: multiple causes, multiple effects of apolipoprotein E4, and multiple therapeutic approaches. Ann Neurol. 2009 Jun; 65(6):623-5. Mahley RW, Huang Y. PMID: 19557874.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    43. Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS. J Lipid Res. 2009 Apr; 50 Suppl:S183-8. Mahley RW, Weisgraber KH, Huang Y. PMID: 19106071; PMCID: PMC2674716.
      View in: PubMed   Mentions: 249     Fields:    Translation:HumansAnimalsCells
    44. Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression. Proc Natl Acad Sci U S A. 2008 Jun 24; 105(25):8718-23. Burt TD, Agan BK, Marconi VC, He W, Kulkarni H, Mold JE, Cavrois M, Huang Y, Mahley RW, Dolan MJ, McCune JM, Ahuja SK. PMID: 18562290; PMCID: PMC2438419.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansCells
    45. Intron-3 retention/splicing controls neuronal expression of apolipoprotein E in the CNS. J Neurosci. 2008 Feb 06; 28(6):1452-9. Xu Q, Walker D, Bernardo A, Brodbeck J, Balestra ME, Huang Y. PMID: 18256266; PMCID: PMC6671590.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    46. Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons. Proc Natl Acad Sci U S A. 2008 Jan 29; 105(4):1343-6. Brodbeck J, Balestra ME, Saunders AM, Roses AD, Mahley RW, Huang Y. PMID: 18212130; PMCID: PMC2234140.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    47. Detrimental effects of apolipoprotein E4: potential therapeutic targets in Alzheimer's disease. Curr Alzheimer Res. 2007 Dec; 4(5):537-40. Mahley RW, Huang Y, Weisgraber KH. PMID: 18220516.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    48. Atherogenic remnant lipoproteins: role for proteoglycans in trapping, transferring, and internalizing. J Clin Invest. 2007 Jan; 117(1):94-8. Mahley RW, Huang Y. PMID: 17200713; PMCID: PMC1716223.
      View in: PubMed   Mentions: 75     Fields:    Translation:Humans
    49. Molecular and cellular mechanisms of apolipoprotein E4 neurotoxicity and potential therapeutic strategies. Curr Opin Drug Discov Devel. 2006 Sep; 9(5):627-41. Huang Y. PMID: 17002223.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    50. Complex disease-associated pharmacogenetics: drug efficacy, drug safety, and confirmation of a pathogenetic hypothesis (Alzheimer's disease). Pharmacogenomics J. 2007 Feb; 7(1):10-28. Roses AD, Saunders AM, Huang Y, Strum J, Weisgraber KH, Mahley RW. PMID: 16770341.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    51. Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus. J Neurosci. 2006 May 10; 26(19):4985-94. Xu Q, Bernardo A, Walker D, Kanegawa T, Mahley RW, Huang Y. PMID: 16687490; PMCID: PMC6674234.
      View in: PubMed   Mentions: 222     Fields:    Translation:AnimalsCells
    52. Putting cholesterol in its place: apoE and reverse cholesterol transport. J Clin Invest. 2006 May; 116(5):1226-9. Mahley RW, Huang Y, Weisgraber KH. PMID: 16670767; PMCID: PMC1451226.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    53. Commentary on "Perspective on a pathogenesis and treatment of Alzheimer's disease." Apolipoprotein E and the mitochondrial metabolic hypothesis. Alzheimers Dement. 2006 Apr; 2(2):71-3. Huang Y, Mahley RW. PMID: 19595858.
      View in: PubMed   Mentions: 3     Fields:    
    54. Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease. Proc Natl Acad Sci U S A. 2006 Apr 11; 103(15):5644-51. Mahley RW, Weisgraber KH, Huang Y. PMID: 16567625; PMCID: PMC1414631.
      View in: PubMed   Mentions: 376     Fields:    Translation:HumansCells
    55. Apolipoprotein E and Alzheimer disease. Neurology. 2006 Jan 24; 66(2 Suppl 1):S79-85. Huang Y. PMID: 16432152.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    56. Apolipoprotein (apo) E4 and Alzheimer's disease: unique conformational and biophysical properties of apoE4 can modulate neuropathology. Acta Neurol Scand Suppl. 2006; 185:8-14. Mahley RW, Huang Y. PMID: 16866905.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    57. Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18694-9. Chang S, ran Ma T, Miranda RD, Balestra ME, Mahley RW, Huang Y. PMID: 16344479; PMCID: PMC1311737.
      View in: PubMed   Mentions: 159     Fields:    Translation:AnimalsCells
    58. Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18700-5. Ye S, Huang Y, Müllendorff K, Dong L, Giedt G, Meng EC, Cohen FE, Kuntz ID, Weisgraber KH, Mahley RW. PMID: 16344478; PMCID: PMC1311738.
      View in: PubMed   Mentions: 119     Fields:    Translation:HumansAnimalsCells
    59. Reactivity of apolipoprotein E4 and amyloid beta peptide: lysosomal stability and neurodegeneration. J Biol Chem. 2006 Feb 03; 281(5):2683-92. Ji ZS, Müllendorff K, Cheng IH, Miranda RD, Huang Y, Mahley RW. PMID: 16298992.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    60. Effect of domain interaction on apolipoprotein E levels in mouse brain. J Neurosci. 2005 Nov 16; 25(46):10658-63. Ramaswamy G, Xu Q, Huang Y, Weisgraber KH. PMID: 16291938; PMCID: PMC6725862.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    61. Apolipoprotein A-V: a potential modulator of plasma triglyceride levels in Turks. J Lipid Res. 2006 Jan; 47(1):144-53. Hodoglugil U, Tanyolaç S, Williamson DW, Huang Y, Mahley RW. PMID: 16258166.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    62. Common polymorphisms of ATP binding cassette transporter A1, including a functional promoter polymorphism, associated with plasma high density lipoprotein cholesterol levels in Turks. Atherosclerosis. 2005 Dec; 183(2):199-212. Hodoglugil U, Williamson DW, Huang Y, Mahley RW. PMID: 15935359.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    63. Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc. J Biol Chem. 2004 Oct 22; 279(43):44795-801. Harris FM, Brecht WJ, Xu Q, Mahley RW, Huang Y. PMID: 15322121.
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    64. ApoE genotype accounts for the vast majority of AD risk and AD pathology. Neurobiol Aging. 2004 May-Jun; 25(5):641-50. Raber J, Huang Y, Ashford JW. PMID: 15172743.
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    65. Apolipoprotein E4 domain interaction occurs in living neuronal cells as determined by fluorescence resonance energy transfer. J Biol Chem. 2004 Jun 11; 279(24):25511-6. Xu Q, Brecht WJ, Weisgraber KH, Mahley RW, Huang Y. PMID: 15054100.
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    66. Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice. J Neurosci. 2004 Mar 10; 24(10):2527-34. Brecht WJ, Harris FM, Chang S, Tesseur I, Yu GQ, Xu Q, Dee Fish J, Wyss-Coray T, Buttini M, Mucke L, Mahley RW, Huang Y. PMID: 15014128; PMCID: PMC6729489.
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    67. Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease. J Mol Neurosci. 2004; 23(3):189-204. Huang Y, Weisgraber KH, Mucke L, Mahley RW. PMID: 15181247.
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    68. Astroglial regulation of apolipoprotein E expression in neuronal cells. Implications for Alzheimer's disease. J Biol Chem. 2004 Jan 30; 279(5):3862-8. Harris FM, Tesseur I, Brecht WJ, Xu Q, Mullendorff K, Chang S, Wyss-Coray T, Mahley RW, Huang Y. PMID: 14585838.
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    69. Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice. Proc Natl Acad Sci U S A. 2003 Sep 16; 100(19):10966-71. Harris FM, Brecht WJ, Xu Q, Tesseur I, Kekonius L, Wyss-Coray T, Fish JD, Masliah E, Hopkins PC, Scearce-Levie K, Weisgraber KH, Mucke L, Mahley RW, Huang Y. PMID: 12939405; PMCID: PMC196910.
      View in: PubMed   Mentions: 161     Fields:    Translation:HumansAnimalsCells
    70. Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation. J Neurosci. 2002 Dec 15; 22(24):10539-48. Buttini M, Yu GQ, Shockley K, Huang Y, Jones B, Masliah E, Mallory M, Yeo T, Longo FM, Mucke L. PMID: 12486146; PMCID: PMC6758409.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    71. Evidence for differential effects of apoE3 and apoE4 on HDL metabolism. J Lipid Res. 2002 Nov; 43(11):1881-9. Hopkins PC, Huang Y, McGuire JG, Pitas RE. PMID: 12401887.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    72. Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells. J Biol Chem. 2002 Jun 14; 277(24):21821-8. Ji ZS, Miranda RD, Newhouse YM, Weisgraber KH, Huang Y, Mahley RW. PMID: 11912196.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    73. Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons. Proc Natl Acad Sci U S A. 2001 Jul 17; 98(15):8838-43. Huang Y, Liu XQ, Wyss-Coray T, Brecht WJ, Sanan DA, Mahley RW. PMID: 11447277; PMCID: PMC37522.
      View in: PubMed   Mentions: 166     Fields:    Translation:HumansCells
    74. Endogenous apolipoprotein E modulates cholesterol efflux and cholesteryl ester hydrolysis mediated by high-density lipoprotein-3 and lipid-free apolipoproteins in mouse peritoneal macrophages. J Mol Med (Berl). 2000; 78(4):217-27. Langer C, Huang Y, Cullen P, Wiesenhütter B, Mahley RW, Assmann G, von Eckardstein A. PMID: 10933584.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    75. Overexpression of apolipoprotein E3 in transgenic rabbits causes combined hyperlipidemia by stimulating hepatic VLDL production and impairing VLDL lipolysis. Arterioscler Thromb Vasc Biol. 1999 Dec; 19(12):2952-9. Huang Y, Ji ZS, Brecht WJ, Rall SC, Taylor JM, Mahley RW. PMID: 10591675.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    76. Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia). Questions, quandaries, and paradoxes. J Lipid Res. 1999 Nov; 40(11):1933-49. Mahley RW, Huang Y, Rall SC. PMID: 10552997.
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    77. Apolipoprotein E: from atherosclerosis to Alzheimer's disease and beyond. Curr Opin Lipidol. 1999 Jun; 10(3):207-17. Mahley RW, Huang Y. PMID: 10431657.
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    78. Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia. J Biol Chem. 1998 Oct 09; 273(41):26388-93. Huang Y, Liu XQ, Rall SC, Taylor JM, von Eckardstein A, Assmann G, Mahley RW. PMID: 9756870.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    79. Apolipoprotein E2 reduces the low density lipoprotein level in transgenic mice by impairing lipoprotein lipase-mediated lipolysis of triglyceride-rich lipoproteins. J Biol Chem. 1998 Jul 10; 273(28):17483-90. Huang Y, Liu XQ, Rall SC, Mahley RW. PMID: 9651338.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    80. Increased expression of apolipoprotein E in transgenic rabbits results in reduced levels of very low density lipoproteins and an accumulation of low density lipoproteins in plasma. J Clin Invest. 1998 May 15; 101(10):2151-64. Fan J, Ji ZS, Huang Y, de Silva H, Sanan D, Mahley RW, Innerarity TL, Taylor JM. PMID: 9593771; PMCID: PMC508803.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    81. Lipid-free apolipoprotein (apo) A-I is converted into alpha-migrating high density lipoproteins by lipoprotein-depleted plasma of normolipidemic donors and apo A-I-deficient patients but not of Tangier disease patients. Atherosclerosis. 1998 May; 138(1):25-34. von Eckardstein A, Huang Y, Kastelein JJ, Geisel J, Real JT, Kuivenhoven JA, Miccoli R, Noseda G, Assmann G. PMID: 9678768.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    82. Genetic factors precipitating type III hyperlipoproteinemia in hypolipidemic transgenic mice expressing human apolipoprotein E2. Arterioscler Thromb Vasc Biol. 1997 Nov; 17(11):2817-24. Huang Y, Rall SC, Mahley RW. PMID: 9409260.
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    83. Effects of genotype and diet on cholesterol efflux into plasma and lipoproteins of normal, apolipoprotein A-I-, and apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 1997 Oct; 17(10):2010-9. Huang Y, Zhu Y, Langer C, Raabe M, Wu S, Wiesenhütter B, Seedorf U, Maeda N, Assmann G, von Eckardstein A. PMID: 9351366.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    84. Apolipoprotein E2 transgenic rabbits. Modulation of the type III hyperlipoproteinemic phenotype by estrogen and occurrence of spontaneous atherosclerosis. J Biol Chem. 1997 Sep 05; 272(36):22685-94. Huang Y, Schwendner SW, Rall SC, Sanan DA, Mahley RW. PMID: 9312550.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    85. A natural apolipoprotein A-I variant, apoA-I (L141R)Pisa, interferes with the formation of alpha-high density lipoproteins (HDL) but not with the formation of pre beta 1-HDL and influences efflux of cholesterol into plasma. J Lipid Res. 1997 Jun; 38(6):1242-53. Miccoli R, Zhu Y, Daum U, Wessling J, Huang Y, Navalesi R, Assmann G, von Eckardstein A. PMID: 9215551.
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    86. Hypolipidemic and hyperlipidemic phenotypes in transgenic mice expressing human apolipoprotein E2. J Biol Chem. 1996 Nov 15; 271(46):29146-51. Huang Y, Schwendner SW, Rall SC, Mahley RW. PMID: 8910571.
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    87. High-density lipoprotein cholesterol as a predictor of coronary heart disease risk. The PROCAM experience and pathophysiological implications for reverse cholesterol transport. Atherosclerosis. 1996 Jul; 124 Suppl:S11-20. Assmann G, Schulte H, von Eckardstein A, Huang Y. PMID: 8831911.
      View in: PubMed   Mentions: 166     Fields:    Translation:Humans
    88. Phospholipid transfer protein mediated conversion of high density lipoproteins generates pre beta 1-HDL. Biochim Biophys Acta. 1996 Jun 11; 1301(3):255-62. von Eckardstein A, Jauhiainen M, Huang Y, Metso J, Langer C, Pussinen P, Wu S, Ehnholm C, Assmann G. PMID: 8664337.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    89. Uptake, transfer, and esterification of cell-derived cholesterol in plasma of patients with familial HDL-deficiency. Z Gastroenterol. 1996 Jun; 34 Suppl 3:143-4. von Eckardstein A, Huang Y, Wu S, Assmann G. PMID: 8767492.
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    90. Effects of the apolipoprotein E polymorphism on uptake and transfer of cell-derived cholesterol in plasma. J Clin Invest. 1995 Dec; 96(6):2693-701. Huang Y, von Eckardstein A, Wu S, Assmann G. PMID: 8675636; PMCID: PMC185976.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    91. Lipoproteins containing apolipoprotein A-IV but not apolipoprotein A-I take up and esterify cell-derived cholesterol in plasma. Arterioscler Thromb Vasc Biol. 1995 Oct; 15(10):1755-63. von Eckardstein A, Huang Y, Wu S, Sarmadi AS, Schwarz S, Steinmetz A, Assmann G. PMID: 7583553.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    92. Generation of pre-beta 1-HDL and conversion into alpha-HDL. Evidence for disturbed HDL conversion in Tangier disease. Arterioscler Thromb Vasc Biol. 1995 Oct; 15(10):1746-54. Huang Y, von Eckardstein A, Wu S, Langer C, Assmann G. PMID: 7583552.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    93. Cholesterol efflux, cholesterol esterification, and cholesteryl ester transfer by LpA-I and LpA-I/A-II in native plasma. Arterioscler Thromb Vasc Biol. 1995 Sep; 15(9):1412-8. Huang Y, von Eckardstein A, Wu S, Assmann G. PMID: 7670956.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    94. Reverse cholesterol transport in plasma of patients with different forms of familial HDL deficiency. Arterioscler Thromb Vasc Biol. 1995 May; 15(5):691-703. von Eckardstein A, Huang Y, Wu S, Funke H, Noseda G, Assmann G. PMID: 7749883.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    95. Physiological role and clinical relevance of high-density lipoprotein subclasses. Curr Opin Lipidol. 1994 Dec; 5(6):404-16. von Eckardstein A, Huang Y, Assmann G. PMID: 7712045.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    96. A plasma lipoprotein containing only apolipoprotein E and with gamma mobility on electrophoresis releases cholesterol from cells. Proc Natl Acad Sci U S A. 1994 Mar 01; 91(5):1834-8. Huang Y, von Eckardstein A, Wu S, Maeda N, Assmann G. PMID: 8127890; PMCID: PMC43258.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    97. Cell-derived unesterified cholesterol cycles between different HDLs and LDL for its effective esterification in plasma. Arterioscler Thromb. 1993 Mar; 13(3):445-58. Huang Y, von Eckardstein A, Assmann G. PMID: 8443149.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
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