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Ashutosh Lal, MD

Title(s)Professor, Pediatrics
SchoolSchool of Medicine
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Cappellini MD, Viprakasit V, Taher AT, Georgiev P, Kuo KHM, Coates T, Voskaridou E, Liew HK, Pazgal-Kobrowski I, Forni GL, Perrotta S, Khelif A, Lal A, Kattamis A, Vlachaki E, Origa R, Aydinok Y, Bejaoui M, Ho PJ, Chew LP, Bee PC, Lim SM, Lu MY, Tantiworawit A, Ganeva P, Gercheva L, Shah F, Neufeld EJ, Thompson A, Laadem A, Shetty JK, Zou J, Zhang J, Miteva D, Zinger T, Linde PG, Sherman ML, Hermine O, Porter J, Piga A. A Phase 3 Trial of Luspatercept in Patients with Transfusion-Dependent ß-Thalassemia. N Engl J Med. 2020 03 26; 382(13):1219-1231. PMID: 32212518.
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    2. Bansal D, Lal A. Taking Stock of Hemophilia, Immune Thrombocytopenia, and Bone Marrow Failure. Indian J Pediatr. 2020 02; 87(2):132-133. PMID: 31900847.
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    3. Bansal D, Lal A. Iron Metabolism, Hemolytic Anemia, and Thalassemia. Indian J Pediatr. 2020 01; 87(1):56-57. PMID: 31828597.
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    4. Lal A, Bansal D. Thalassemia: Common Clinical Queries in Management. Indian J Pediatr. 2020 01; 87(1):75-81. PMID: 31620986.
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    5. Lal A. Iron in Health and Disease: An Update. Indian J Pediatr. 2020 01; 87(1):58-65. PMID: 31520313.
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    6. A. E. Kulozik, F. Locatelli, E. Yannaki, J. B. Porter, I. Thuret, M. G. Sauer, A. Lal, J. L. Kwiatkowski, H. Elliot, G. Tao, R. A. Colvin, A. A. Thompson. RESULTS FROM THE PHASE 3 NORTHSTAR-3 STUDY EVALUATING LENTIGLOBIN GENE THERAPY IN PATIENTS WITH TRANSFUSION-DEPENDENT ß-THALASSAEMIA AND A ß0 OR IVS-I-110 MUTATION AT BOTH ALLELES OF THE HBB GENE. HemaSphere. 2019 Jun 1; 3:21-22.
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    7. Franco Locatelli, Mark C. Walters, Janet L. Kwiatkowski, John Porter, Martin G. Sauer, Isabelle Thuret, Suradej Hongeng, Andreas E. Kulozik, Ashutosh Lal, Adrian J. Thrasher, Evangelia Yannaki, Heidi Elliot, Ge Tao, Mohammed Asmal, Alexis A. Thompson. Lentiglobin Gene Therapy for Patients with Transfusion-Dependent ß-Thalassemia (TDT): Results from the Phase 3 Northstar-2 and Northstar-3 Studies. Blood. 2018 Nov 29; 132(Supplement 1):1025-1025.
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    8. Ashutosh Lal, William Avrin, Viktoriia Kolotovska, Lisa Calvelli, Marcela Weyhmiller. Advances in Biomagnetic Liver Susceptometry Allow the Measurement of Liver Iron Concentration with a Room Temperature Sensor. Blood. 2018 Nov 29; 132(Supplement 1):4890-4890.
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    9. Ashutosh Lal, Sujit Sheth, Sandra Gilbert, Janet L. Kwiatkowski. Thalassemia Management Checklists: Quick Reference Guides to Reduce Disparities in the Care of Patients with Transfusion-Dependent Thalassemia. Blood. 2018 Nov 29; 132(Supplement 1):2233-2233.
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    10. Goldberg EK, Neogi S, Lal A, Higa A, Fung E. Nutritional Deficiencies Are Common in Patients with Transfusion-Dependent Thalassemia and Associated with Iron Overload. J Food Nutr Res (Newark). 2018; 6(10):674-681. PMID: 30569002.
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    11. Lal A, Wong TE, Andrews J, Balasa VV, Chung JH, Forester CM, Ikeda AK, Keel SB, Pagano MB, Puthenveetil G, Shah SJ, Yu JC, Vichinsky EP. Transfusion practices and complications in thalassemia. Transfusion. 2018 12; 58(12):2826-2835. PMID: 30260477.
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    12. Bseikri M, McCann JC, Lal A, Fong E, Graves K, Goldrich A, Block D, Gildengoren GL, Mietus-Snyder M, Shigenaga M, Suh J, Hardy K, Ames BN. A novel nutritional intervention improves lung function in overweight/obese adolescents with poorly controlled asthma: the Supplemental Nutrition in Asthma Control (SNAC) pilot study. FASEB J. 2018 Jul 19; fj201700338. PMID: 30024788.
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    13. Vichinsky E, Cohen A, Thompson AA, Giardina PJ, Lal A, Paley C, Cheng WY, McCormick N, Sasane M, Qiu Y, Kwiatkowski JL. Epidemiologic and clinical characteristics of nontransfusion-dependent thalassemia in the United States. Pediatr Blood Cancer. 2018 07; 65(7):e27067. PMID: 29637688.
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    14. Kreger EM, Singer ST, Witt RG, Sweeters N, Lianoglou B, Lal A, Mackenzie TC, Vichinsky E. Favorable outcomes after in utero transfusion in fetuses with alpha thalassemia major: a case series and review of the literature. Prenat Diagn. 2016 Dec; 36(13):1242-1249. PMID: 27862048.
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    15. Melissa Cervantes, Ashutosh Lal, Anne M Marsh, Ellen B. Fung. Assessing Bone Quality Using Trabecular Bone Score in Patients with Hemoglobinopathies. Blood. 2016 Dec 2; 128(22):3629-3629.
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    16. Ashutosh Lal, Marcela G Weyhmiller, Elliott Vichinsky. Threshold Ferritin Values to Predict Control of Liver Iron Burden in Thalassemia. Blood. 2016 Dec 2; 128(22):4824-4824.
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    17. Katie Carlberg, Nikhil Bose, Jingyi Deng, Ashutosh Lal, Henry Erlich, Cassandra Calloway. Towards the Development of a Noninvasive Prenatal Test for Beta-Thalassemia: Utilization of Probe Capture Enrichment and Next Generation Sequencing. Blood. 2016 Dec 2; 128(22):3622-3622.
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    18. Patrick B Walter, Michael Minkley, Caitlin Curtis, Hodge Maeve, Razavi Morty, Sarah Ewing, Ashutosh Lal, Anne Higa, David Killilea, Terry Pearson, Ellen B. Fung. Implications of Low Zinc and Copper Levels As Well As Altered Iron Trafficking Proteins on Oxidant Stress in Patients with Transfusion Dependant Thalassemia. Blood. 2016 Dec 2; 128(22):1289-1289.
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    19. Patrick B Walter, Michael Minkley, Caitlin Curtis, Maeve Hodge, Razavi Morty, Sarah Ewing, Zoe Ennis, Ashutosh Lal, Annie Higa, David Killilea, Terry Pearson, Ellen Fung. 469 Implications of Altered Trace Minerals and Iron Trafficking Proteins on Oxidant Stress in Thalassemia. Free Radical Biology and Medicine. 2016 Nov 1; 100:s194-s195.
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    20. Lal A, Gomez E, Calloway C. Increased mitochondrial DNA deletions and copy number in transfusion-dependent thalassemia. JCI Insight. 2016 Aug 04; 1(12). PMID: 27583305.
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    21. Lal A. Assessment and treatment of pain in thalassemia. Ann N Y Acad Sci. 2016 03; 1368(1):65-72. PMID: 27124110.
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    22. E.B. Fung, C. Schroepfer, A. Lal. 19. Nutrition for patients with thalassemia. Handbook of nutrition and diet in leukemia and blood disease therapy. 2016 Feb 9; 12:315-334.
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    23. Patrick B. Walter, Nick Slater, Paul Harmatz, Annie Higa, Vivian Ng, Marcels Weyhmiller, Patricia Evans, John B Porter, Nancy Sweeters, Jackson Price, David Killilea, Lynne Neumayr, Ashutosh Lal, Elliott Vichinsky. Iron Level and Monocyte Morphology Predict TLR4 Expression and Reactive Oxygen Species Production Which Influences Chronic Inflammation in ß-Thalassemia. Blood. 2015 Dec 3; 126(23):950-950.
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    24. Ellen Fung, Nan Luo, Ginny Gildengorin, Ashutosh Lal. The effect of iron chelators on bone health in patients with thalassemia. Bone Abstracts. 2015 Jun 9.
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    25. Fung EB, Gildengorin G, Talwar S, Hagar L, Lal A. Zinc status affects glucose homeostasis and insulin secretion in patients with thalassemia. Nutrients. 2015 Jun 02; 7(6):4296-307. PMID: 26043030.
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    26. McCann JC, Shigenaga MK, Mietus-Snyder ML, Lal A, Suh JH, Krauss RM, Gildengorin GL, Goldrich AM, Block DS, Shenvi SV, McHugh TH, Olson DA, Ames BN. A multicomponent nutrient bar promotes weight loss and improves dyslipidemia and insulin resistance in the overweight/obese: chronic inflammation blunts these improvements. FASEB J. 2015 Aug; 29(8):3287-301. PMID: 25900806.
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    27. Lal A, Patterson L, Goldrich A, Marsh A. Point-of-care end-tidal carbon monoxide reflects severity of hemolysis in sickle cell anemia. Pediatr Blood Cancer. 2015 May; 62(5):912-4. PMID: 25683629.
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    28. Ashutosh Lal, Kristen Yen, Lasandra Patterson, Alisa Goldrich, Anne M Marsh, Anish Bhatnagar. Elevated End-Tidal Carbon Monoxide Concentration in Children with Sickle Cell Anemia. Blood. 2014 Dec 6; 124(21):1390-1390.
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    29. Ellen B. Fung, Neogi Sushrita, Drucilla Haines, Connie Schroepfer, Ashutosh Lal. Dietary Intake Insufficient to Support Nutritional Adequacy in Patients with Thalassemia. Blood. 2014 Dec 6; 124(21):1361-1361.
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    30. Nicholas Richard Slater, Paul Harmatz, Annie Higa, Vivian Ng, Marcela G G Weyhmiller, Patricia Evans, John B Porter, Nancy Sweeters, Jackson Price, Alisha Manji, Angela Manocha, David W Killilea, Ashutosh Lal, Lynne Neumayr, Elliot Vichinsky, Patrick B Walter. 138 Iron Overload and Hemolysis Modulate Monocytes and Inflammation in ß-Thalassemia. Free Radical Biology and Medicine. 2014 Nov 1; 76:s65.
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    31. Esteban Gomez, Cassandra Calloway, Sang Hoon Lee, Jay Kim, Navpreet Dhillon, Ginny Gildengorin, Ashutosh Lal. Mitochondrial Genome Changes As a Measure Of Iron-Induced Mitochondrial Stress In Transfusion-Dependent Thalassemia. Blood. 2013 Nov 15; 122(21):2256-2256.
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    32. Patrick B Walter, Annie Higa, Vivian Ng, Marcela G Weyhmiller, Nick R Slater, Patricia Evans, John B Porter, Nancy Sweeters, Jackson Price, Alisha Manji, David Killilea, Ashutosh Lal, Elliott Vichinsky. Association Of Cardiac Iron By T2* With Innate Immune Markers In Transfusion-Dependent Thalassemia Patients Undergoing Combined Chelation Therapy. Blood. 2013 Nov 15; 122(21):3450-3450.
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    33. Haven M. Allard, Marcela G. Weyhmiller, Ashutosh Lal, Ellen B. Fung. In-Accuracy Of Bone Density Measurements By DXA In Patients With Hemoglobinopathies and Iron Overload. Blood. 2013 Nov 15; 122(21):966-966.
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    34. Patrick B Walter, Paul Harmatz, Annie Higa, Vivian Ng, Marcela G Weyhmiller, Patricia Evans, John B. Porter, Nancy Sweeters, Jackson Price, Alisha Manji, David Killilea, Ashutosh Lal, Elliott Vichinsky. Innate Immune Cell Expression of Pattern Recognition Receptors From ß-Thalassemia Patients During Intensive Combination Chelation Therapy. Blood. 2012 Nov 16; 120(21):1025-1025.
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    35. Lal A, Porter J, Sweeters N, Ng V, Evans P, Neumayr L, Kurio G, Harmatz P, Vichinsky E. Combined chelation therapy with deferasirox and deferoxamine in thalassemia. Blood Cells Mol Dis. 2013 Feb; 50(2):99-104. PMID: 23151373.
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    36. Mietus-Snyder ML, Shigenaga MK, Suh JH, Shenvi SV, Lal A, McHugh T, Olson D, Lilienstein J, Krauss RM, Gildengoren G, McCann JC, Ames BN. A nutrient-dense, high-fiber, fruit-based supplement bar increases HDL cholesterol, particularly large HDL, lowers homocysteine, and raises glutathione in a 2-wk trial. FASEB J. 2012 Aug; 26(8):3515-27. PMID: 22549511.
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    37. Ellen B Fung, Kathryn N Reget, Drucilla Haines, Aenor Sawyer, Ashutosh Lal. Exploring Vertebral Height Deficits in Patients with Thalassemia and Sickle Cell Disease,. Blood. 2011 Nov 18; 118(21):3198-3198.
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    38. Sylvia T Singer, Elliott Vichinsky, Marcelle Cedars, Ginny Gildengorin, Jung H Suh, Ashutosh Lal. Oxidative Stress and Reproductive Capacity in Iron Overload Thalassemia Major Women. Blood. 2011 Nov 18; 118(21):2155-2155.
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    39. Fung EB, Aguilar C, Micaily I, Haines D, Lal A. Treatment of vitamin D deficiency in transfusion-dependent thalassemia. Am J Hematol. 2011 Oct; 86(10):871-3. PMID: 21818763.
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    40. Lal A, Goldrich ML, Haines DA, Azimi M, Singer ST, Vichinsky EP. Heterogeneity of hemoglobin H disease in childhood. N Engl J Med. 2011 Feb 24; 364(8):710-8. PMID: 21345100.
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    41. Lal A, Ames BN. Association of chromosome damage detected as micronuclei with hematological diseases and micronutrient status. Mutagenesis. 2011 Jan; 26(1):57-62. PMID: 21164183.
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    42. Ashutosh Lal, Nancy Sweeters, Vivian Ng, Drucilla Foote, Patricia Evans, Lynne Neumayr, Gregory Kurio, Paul Harmatz, John B. Porter, Elliott Vichinsky. Combined Chelation Therapy with Deferasirox and Deferoxamine In Transfusion-Dependent Thalassemia. Blood. 2010 Nov 19; 116(21):4269-4269.
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    43. Catherine Garie´py, Ashutosh Lal, Ellen Fung. Reduced Physical Activity In Adult and Pediatric Patients with Thalassemia. Blood. 2010 Nov 19; 116(21):5174-5174.
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    44. Ashutosh Lal, Michael Lee Goldrich, Drucilla Foote, Mahin Azimi, Sylvia Titi Singer, Elliott Vichinsky. Longitudinal Follow-up From Newborn Screening Reveals Deletional Hemoglobin H Disease and Hemoglobin H Constant Spring Disease Are Distinct Thalassemia Syndromes. Blood. 2010 Nov 19; 116(21):4260-4260.
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    45. Ashutosh Lal, Ida Micaily, Drucilla Foote, Ellen Fung. A Simple Regimen to Correct Vitamin D Deficiency In Transfusion-Dependent Thalassemia with High-Dose Ergocalciferol. Blood. 2010 Nov 19; 116(21):4261-4261.
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    46. Ashutosh Lal, Elliott P Vichinsky. Sickle Cell Disease. Postgraduate Haematology. 2010 Oct 28; 109-125.
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    47. Anurag K. Agrawal, Jung H. Suh, Bruce N. Ames, Elliott P. Vichinsky, Ashutosh Lal. Heightened Sulfur Amino Acid Oxidation in Plasma and Erythrocytes in ß-Thalassemia Major. Blood. 2009 Nov 20; 114(22):4065-4065.
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    48. Ashutosh Lal, Nancy Sweeters, Matt Herz, Dru Foote, Lynne Neumayr, Greg Kurio, Paul R Harmatz, Elliott P Vichinsky. Safety of Combined Chelation Therapy with Deferasirox and Deferoxamine in Transfusion-Dependent Thalassemia. Blood. 2009 Nov 20; 114(22):2021-2021.
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    49. Suh JH, Kim R, Yavuz B, Lee D, Lal A, Ames BN, Shigenaga MK. Clinical assay of four thiol amino acid redox couples by LC-MS/MS: utility in thalassemia. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Oct 15; 877(28):3418-27. PMID: 19616487.
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    50. Ellen Fung, Yan Xu, Janet Kwiatkowski, Sylvia Titi Singer, Ashutosh Lal, Maria G Vogiatzi, Nancy F. Olivieri, Ellis J. Neufeld, Elliott Vichinsky, Patricia Giardina. Body Composition and Its Relationship to Growth and Bone Mass in Patients with Thalassemia. Blood. 2008 Nov 16; 112(11):3890-3890.
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    51. Lal A, Atamna W, Killilea DW, Suh JH, Ames BN. Lipoic acid and acetyl-carnitine reverse iron-induced oxidative stress in human fibroblasts. Redox Rep. 2008; 13(1):2-10. PMID: 18284845.
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    52. Lal A, Fung EB, Pakbaz Z, Hackney-Stephens E, Vichinsky EP. Bone mineral density in children with sickle cell anemia. Pediatr Blood Cancer. 2006 Dec; 47(7):901-6. PMID: 16317761.
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    53. A. Lal, E.B. Fung, Z. Pakbaz, E.P. Vichinsky. Bone mineral density in children and young adults with beta-thalassemia major conventionally treated—RESPONSE. Pediatric Blood & Cancer. 2006 Jul 1; 47(1):115-115.
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    54. Schmidt ML, Lal A, Seeger RC, Maris JM, Shimada H, O'Leary M, Gerbing RB, Matthay KK. Favorable prognosis for patients 12 to 18 months of age with stage 4 nonamplified MYCN neuroblastoma: a Children's Cancer Group Study. J Clin Oncol. 2005 Sep 20; 23(27):6474-80. PMID: 16116154.
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    55. Ashutosh Lal, Elliott P Vichinsky. Sickle Cell Disease. Postgraduate Haematology. 2005 Mar 30; 104-118.
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    56. Offer T, Bhagat A, Lal A, Atamna W, Singer ST, Vichinsky EP, Kuypers FA, Ames BN. Measuring chromosome breaks in patients with thalassemia. Ann N Y Acad Sci. 2005; 1054:439-44. PMID: 16339694.
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    57. Lal A, Vichinsky E. The role of fetal hemoglobin-enhancing agents in thalassemia. Semin Hematol. 2004 Oct; 41(4 Suppl 6):17-22. PMID: 15534853.
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