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Mark Jacobson, MD

Address1001 Potrero Ave
San Francisco CA 94110
Phone415-476-4082
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoM.D.1981 Medicine
    Kaiser Foundation Hospital, Oakland, CAInternship/Residency1984Medicine
    University of California, Los AngelesFellowship1986Infectious Diseases
    Collapse Awards and Honors
    UCSF2007Positive Health Program Teaching Award
    UCSF2013AIDS Research Institute Sarlo Award for Teaching Excellence

    Collapse Overview 
    Collapse Overview
    Dr. Jacobson is a clinician, educator, and researcher who has specialized in HIV/AIDS and its complications since joining the UCSF faculty in 1986. His earlier career involved leading multicenter, interventional trials that focused on developing effective treatments for AIDS-associated opportunistic infections. His subsequent research was translational, investigating protective immunity against chronic viral infections, in particular cytomegalovirus (CMV), HIV, and human papillomavirus (HPV). He now teaches medicine residents and medical students, provides clinical care and directs urgent care medical services for the Ward 86 HIV clinic at San Francisco General Hospital, and is the editor for the Ward 86 Medical Management Recommendations posted on UCSF’s HIV InSite website. Dr. Jacobson is also the author of Sensing Light, a novel about the unfolding of the AIDS epidemic in 1980s San Francisco from the perspective of front-line, treating physicians (see http://markajacobsonauthor.com/).


    Collapse Research 
    Collapse Research Activities and Funding
    Aberrant T Cell Function and Immunopathogenesis of CMV Immune Recovery Uveitis
    NIH/NEI R21EY018559Sep 1, 2007 - Aug 31, 2010
    Role: Principal Investigator
    HIV Epitope Specific T Cell Responses and Control of HIV Replication
    NIH/NIAID R21AI068549May 15, 2007 - Apr 30, 2010
    Role: Principal Investigator
    CMV Immune Response &Long-Term Outcome of CMV Retinitis
    NIH/NEI R01EY015651Feb 1, 2004 - Jan 31, 2007
    Role: Principal Investigator
    Adjunct rhIL-12 enhance THI response to viral vaccine?
    NIH/NIAID R01AI049538May 1, 2002 - Oct 31, 2005
    Role: Principal Investigator
    High Performance Computing for Biomedical Research
    NIH P41RR006009Sep 1, 1990 - Jul 31, 2013
    Role: Co-Investigator
    UCSF-GVI Center for AIDS Research
    NIH/NIAID P30AI027763Sep 30, 1988 - Aug 31, 2017
    Role: Co-Investigator
    UCSF-GIVI CENTER FOR AIDS RESEARCH
    NIH/NIMH P30MH059037Sep 30, 1988 - Feb 28, 2003
    Role: Co-Principal Investigator
    ADULT AIDS CLINICAL TRIALS UNIT
    NIH/NIAID U01AI027663Jun 30, 1986 - Dec 31, 2006
    Role: Co-Principal Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000083Oct 1, 1974 - Nov 30, 2007
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse Faculty Mentoring
    Collapse Clinical Trials
    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Wu J, Baxt R, Jacobson M. Polycyclic Eruption of the Thighs. JAMA Dermatol. 2017 Jan 01; 153(1):83-84. PMID: 27653457.
      View in: PubMed
    2. Weinberg A, Bosch R, Bennett K, Tovar-Salazar A, Benson CA, Collier AC, Zolopa A, Gulick RM, Wohl D, Polsky B, Erice A, Jacobson M. Regulatory T cells and the risk of CMV end-organ disease in patients with AIDS. J Acquir Immune Defic Syndr. 2014 May 1; 66(1):25-32. PMID: 24378728; PMCID: PMC3981937.
    3. Wohl DA, Kendall MA, Feinberg J, Alston-Smith B, Owens S, Chafey S, Marco M, Maxwell S, Benson C, Keiser P, van der Horst C, Jacobson M. The clinical impact of continuing to prescribe antiretroviral therapy in patients with advanced AIDS who manifest no virologic or immunologic benefit. PLoS One. 2013; 8(11):e78676. PMID: 24260125; PMCID: PMC3829816.
    4. Meyer AC, Jacobson M. Asymptomatic cryptococcemia in resource-limited settings. Curr HIV/AIDS Rep. 2013 Sep; 10(3):254-63. PMID: 23715897; PMCID: PMC3809900.
    5. Jacobson M, Lurain N, Hunt P. Cytomegalovirus viraemia in the modern antiretroviral era(*). HIV Med. 2011 Aug; 12(7):387-8. PMID: 21729228.
      View in: PubMed
    6. Hunt PW, Martin JN, Sinclair E, Epling L, Teague J, Jacobson M, Tracy RP, Corey L, Deeks SG. Valganciclovir reduces T cell activation in HIV-infected individuals with incomplete CD4+ T cell recovery on antiretroviral therapy. J Infect Dis. 2011 May 15; 203(10):1474-83. PMID: 21502083; PMCID: PMC3080892.
    7. Hartigan-O'Connor DJ, Jacobson M, Tan QX, Sinclair E. Development of cytomegalovirus (CMV) immune recovery uveitis is associated with Th17 cell depletion and poor systemic CMV-specific T cell responses. Clin Infect Dis. 2011 Feb 1; 52(3):409-17. PMID: 21189271; PMCID: PMC3060886.
    8. Jagannathan P, Davis E, Jacobson M, Huang L. Life-threatening immune reconstitution inflammatory syndrome after Pneumocystis pneumonia: a cautionary case series. AIDS. 2009 Aug 24; 23(13):1794-6. PMID: 19684486.
      View in: PubMed
    9. Wohl DA, Kendall MA, Andersen J, Crumpacker C, Spector SA, Feinberg J, Alston-Smith B, Owens S, Chafey S, Marco M, Maxwell S, Lurain N, Jabs D, Benson C, Keiser P, Jacobson M. Low rate of CMV end-organ disease in HIV-infected patients despite low CD4+ cell counts and CMV viremia: results of ACTG protocol A5030. HIV Clin Trials. 2009 May-Jun; 10(3):143-52. PMID: 19632953; PMCID: PMC2754189.
    10. Jacobson M, Ditmer DP, Sinclair E, Martin JN, Deeks SG, Hunt P, Mocarski ES, Shiboski C. Human herpesvirus replication and abnormal CD8+ T cell activation and low CD4+ T cell counts in antiretroviral-suppressed HIV-infected patients. PLoS One. 2009; 4(4):e5277. PMID: 19381272; PMCID: PMC2667217.
    11. Jacobson M, Adler SP, Sinclair E, Black D, Smith A, Chu A, Moss RB, Wloch MK. A CMV DNA vaccine primes for memory immune responses to live-attenuated CMV (Towne strain). Vaccine. 2009 Mar 4; 27(10):1540-8. PMID: 19168107.
      View in: PubMed
    12. Graber CJ, Jacobson M, Perdreau-Remington F, Chambers HF, Diep BA. Recurrence of skin and soft tissue infection caused by methicillin-resistant Staphylococcus aureus in a HIV primary care clinic. J Acquir Immune Defic Syndr. 2008 Oct 1; 49(2):231-3. PMID: 18820536.
      View in: PubMed
    13. Jacobson M, Tan QX, Girling V, Poon C, Van Natta M, Jabs DA, Inokuma M, Maecker HT, Bredt B, Sinclair E. Poor predictive value of cytomegalovirus (CMV)-specific T cell assays for the development of CMV retinitis in patients with AIDS. Clin Infect Dis. 2008 Feb 1; 46(3):458-66. PMID: 18173357; PMCID: PMC2666016.
    14. Owen RE, Sinclair E, Emu B, Heitman JW, Hirschkorn DF, Epling CL, Tan QX, Custer B, Harris JM, Jacobson M, McCune JM, Martin JN, Hecht FM, Deeks SG, Norris PJ. Loss of T cell responses following long-term cryopreservation. J Immunol Methods. 2007 Sep 30; 326(1-2):93-115. PMID: 17707394; PMCID: PMC2065759.
    15. Rajendran PM, Young DM, Maurer T, Chambers HF, Jacobson M, Harris HW. Antibiotic use in the treatment of soft tissue abscesses: a survey of current practice. Surg Infect (Larchmt). 2007 Apr; 8(2):237-8. PMID: 17437370.
      View in: PubMed
    16. Jacobson M. Do CD4+ T cell functional responses to Epstein-Barr virus provide protective immunity against CNS lymphoma in AIDS? PLoS Med. 2007 Mar 27; 4(3):e110. PMID: 17388670; PMCID: PMC1831741.
    17. Sinclair E, Tan QX, Sharp M, Girling V, Poon C, Natta MV, Jabs DA, Inokuma M, Maecker HT, Bredt B, Jacobson M. Protective immunity to cytomegalovirus (CMV) retinitis in AIDS is associated with CMV-specific T cells that express interferon- gamma and interleukin-2 and have a CD8+ cell early maturational phenotype. J Infect Dis. 2006 Dec 1; 194(11):1537-46. PMID: 17083038.
      View in: PubMed
    18. Jacobson M, Sinclair E, Bredt B, Agrillo L, Black D, Epling CL, Carvidi A, Ho T, Bains R, Girling V, Adler SP. Safety and immunogenicity of Towne cytomegalovirus vaccine with or without adjuvant recombinant interleukin-12. Vaccine. 2006 Jun 19; 24(25):5311-9. PMID: 16701925.
      View in: PubMed
    19. Jacobson M, Sinclair E, Bredt B, Agrillo L, Black D, Epling CL, Carvidi A, Ho T, Bains R, Adler SP. Antigen-specific T cell responses induced by Towne cytomegalovirus (CMV) vaccine in CMV-seronegative vaccine recipients. J Clin Virol. 2006 Mar; 35(3):332-7. PMID: 16387547.
      View in: PubMed
    20. Jacobson M, Nicolau DP, Sutherland C, Smith A, Aweeka F. Pharmacokinetics of clarithromycin extended-release (ER) tablets in patients with AIDS. HIV Clin Trials. 2005 Sep-Oct; 6(5):246-53. PMID: 16306031.
      View in: PubMed
    21. Wohl DA, Kendall MA, Owens S, Holland G, Nokta M, Spector SA, Schrier R, Fiscus S, Davis M, Jacobson M, Currier JS, Squires K, Alston-Smith B, Andersen J, Freeman WR, Higgins M, Torriani FJ. The safety of discontinuation of maintenance therapy for cytomegalovirus (CMV) retinitis and incidence of immune recovery uveitis following potent antiretroviral therapy. HIV Clin Trials. 2005 May-Jun; 6(3):136-46. PMID: 16192248.
      View in: PubMed
    22. Jabs DA, Holbrook JT, Van Natta ML, Clark R, Jacobson M, Kempen JH, Murphy RL. Risk factors for mortality in patients with AIDS in the era of highly active antiretroviral therapy. Ophthalmology. 2005 May; 112(5):771-9. PMID: 15878056.
      View in: PubMed
    23. Jacobson M. Editorial comment: failure of HAART to reconstitute CMV-specific protective immunity. AIDS Read. 2005 Apr; 15(4):188. PMID: 15844239.
      View in: PubMed
    24. D'Amico R, Yang Y, Mildvan D, Evans SR, Schnizlein-Bick CT, Hafner R, Webb N, Basar M, Zackin R, Jacobson M. Lower CD4+ T lymphocyte nadirs may indicate limited immune reconstitution in HIV-1 infected individuals on potent antiretroviral therapy: analysis of immunophenotypic marker results of AACTG 5067. J Clin Immunol. 2005 Mar; 25(2):106-15. PMID: 15821887.
      View in: PubMed
    25. Winter HR, Trapnell CB, Slattery JT, Jacobson M, Greenspan DL, Hooton TM, Unadkat JD. The effect of clarithromycin, fluconazole, and rifabutin on dapsone hydroxylamine formation in individuals with human immunodeficiency virus infection (AACTG 283). Clin Pharmacol Ther. 2004 Dec; 76(6):579-87. PMID: 15592329.
      View in: PubMed
    26. Winter HR, Trapnell CB, Slattery JT, Jacobson M, Greenspan DL, Hooton TM, Unadkat JD. The effect of clarithromycin, fluconazole, and rifabutin on sulfamethoxazole hydroxylamine formation in individuals with human immunodeficiency virus infection (AACTG 283). Clin Pharmacol Ther. 2004 Oct; 76(4):313-22. PMID: 15470330.
      View in: PubMed
    27. Shacklett BL, Cox CA, Quigley MF, Kreis C, Stollman NH, Jacobson M, Andersson J, Sandberg JK, Nixon DF. Abundant expression of granzyme A, but not perforin, in granules of CD8+ T cells in GALT: implications for immune control of HIV-1 infection. J Immunol. 2004 Jul 1; 173(1):641-8. PMID: 15210827.
      View in: PubMed
    28. Jacobson M, Maecker HT, Orr PL, D'Amico R, Van Natta M, Li XD, Pollard RB, Bredt BM. Results of a cytomegalovirus (CMV)-specific CD8+/interferon- gamma+ cytokine flow cytometry assay correlate with clinical evidence of protective immunity in patients with AIDS with CMV retinitis. J Infect Dis. 2004 Apr 15; 189(8):1362-73. PMID: 15073672.
      View in: PubMed
    29. Marshall BC, Jacobson M, Adler SP. Avidity of antibodies to cytomegalovirus in HIV-seropositive patients with and without CMV retinitis. Viral Immunol. 2004; 17(1):101-8. PMID: 15018666.
      View in: PubMed
    30. Sinclair E, Black D, Epling CL, Carvidi A, Josefowicz SZ, Bredt BM, Jacobson M. CMV antigen-specific CD4+ and CD8+ T cell IFNgamma expression and proliferation responses in healthy CMV-seropositive individuals. Viral Immunol. 2004; 17(3):445-54. PMID: 15357911; PMCID: PMC1993826.
    31. Jacobson JM, Lederman MM, Spritzler J, Valdez H, Tebas P, Skowron G, Wang R, Jackson JB, Fox L, Landay A, Gilbert MJ, O'Neil D, Bancroft L, Al-Harthi L, Jacobson M, Merigan TC, Glesby MJ. Granulocyte-macrophage colony-stimulating factor induces modest increases in plasma human immunodeficiency virus (HIV) type 1 RNA levels and CD4+ lymphocyte counts in patients with uncontrolled HIV infection. J Infect Dis. 2003 Dec 15; 188(12):1804-14. PMID: 14673758.
      View in: PubMed
    32. Shacklett BL, Cox CA, Sandberg JK, Stollman NH, Jacobson M, Nixon DF. Trafficking of human immunodeficiency virus type 1-specific CD8+ T cells to gut-associated lymphoid tissue during chronic infection. J Virol. 2003 May; 77(10):5621-31. PMID: 12719554; PMCID: PMC154016.
    33. Jacobson M, Liu L, Khayam-Bashi H, Deeks SG, Hecht FM, Kahn J. Absolute or total lymphocyte count as a marker for the CD4 T lymphocyte criterion for initiating antiretroviral therapy. AIDS. 2003 Apr 11; 17(6):917-9. PMID: 12660541.
      View in: PubMed
    34. Jacobson M, Khayam-Bashi H, Martin JN, Black D, Ng V. Effect of long-term highly active antiretroviral therapy in restoring HIV-induced abnormal B-lymphocyte function. J Acquir Immune Defic Syndr. 2002 Dec 15; 31(5):472-7. PMID: 12473834.
      View in: PubMed
    35. Jacobson M, Bredt BM. Association of cytomegalovirus (CMV)-specific CD4+ T lymphocyte reactivity and protective immunity against acquired immunodeficiency syndrome-related CMV retinitis. J Infect Dis. 2002 Dec 1; 186(11):1701-2; author reply 1702-3. PMID: 12447752.
      View in: PubMed
    36. Lalezari JP, Aberg JA, Wang LH, Wire MB, Miner R, Snowden W, Talarico CL, Shaw S, Jacobson M, Drew WL. Phase I dose escalation trial evaluating the pharmacokinetics, anti-human cytomegalovirus (HCMV) activity, and safety of 1263W94 in human immunodeficiency virus-infected men with asymptomatic HCMV shedding. Antimicrob Agents Chemother. 2002 Sep; 46(9):2969-76. PMID: 12183255; PMCID: PMC127448.
    37. Nokta MA, Holland F, De Gruttola V, Emery VC, Jacobson M, Griffiths P, Pollard RB, Feinberg JE. Cytomegalovirus (CMV) polymerase chain reaction profiles in individuals with advanced human immunodeficiency virus infection: relationship to CMV disease. J Infect Dis. 2002 Jun 15; 185(12):1717-22. PMID: 12085316.
      View in: PubMed
    38. Jacobson M, Spritzler J, Landay A, Chan E, Katzenstein D, Schock B, Fox L, Roe J, Kundu S, Pollard R. A Phase I, placebo-controlled trial of multi-dose recombinant human interleukin-12 in patients with HIV infection. AIDS. 2002 May 24; 16(8):1147-54. PMID: 12004273.
      View in: PubMed
    39. Aberg JA, Wong MK, Flamm R, Notario GF, Jacobson M. Presence of macrolide resistance in respiratory flora of HIV-Infected patients receiving either clarithromycin or azithromycin for Mycobacterium avium complex prophylaxis. HIV Clin Trials. 2001 Nov-Dec; 2(6):453-9. PMID: 11742432.
      View in: PubMed
    40. Jacobson M, Schrier R, McCune JM, Torriani FJ, Holland GN, O'Donnell JJ, Freeman WR, Bredt BM. Cytomegalovirus (CMV)-specific CD4+ T lymphocyte immune function in long-term survivors of AIDS-related CMV end-organ disease who are receiving potent antiretroviral therapy. J Infect Dis. 2001 May 1; 183(9):1399-404. PMID: 11294673.
      View in: PubMed
    41. Chin-Hong PV, Sutton DA, Roemer M, Jacobson M, Aberg JA. Invasive fungal sinusitis and meningitis due to Arthrographis kalrae in a patient with AIDS. J Clin Microbiol. 2001 Feb; 39(2):804-7. PMID: 11158158; PMCID: PMC87827.
    42. Angel JB, Jacobson M, Skolnik PR, Giordano M, Shapiro L, LeBeaut A, Greaves W, Fuchs AC. A multicenter, randomized, double-blind, placebo-controlled trial of recombinant human interleukin-10 in HIV-infected subjects. AIDS. 2000 Nov 10; 14(16):2503-8. PMID: 11101061.
      View in: PubMed
    43. Jacobson M, Hardy D, Connick E, Watson J, DeBruin M. Phase 1 trial of a single dose of recombinant human interleukin-12 in human immunodeficiency virus-infected patients with 100-500 CD4 cells/microL. J Infect Dis. 2000 Oct; 182(4):1070-6. PMID: 10979901.
      View in: PubMed
    44. Jacobson M, Stanley H, Holtzer C, Margolis TP, Cunningham ET. Natural history and outcome of new AIDS-related cytomegalovirus retinitis diagnosed in the era of highly active antiretroviral therapy. Clin Infect Dis. 2000 Jan; 30(1):231-3. PMID: 10619774.
      View in: PubMed
    45. Aweeka FT, Jacobson M, Martin-Munley S, Hedman A, Schoenfeld P, Omachi R, Tsunoda S, Gambertoglio JG. Effect of renal disease and hemodialysis on foscarnet pharmacokinetics and dosing recommendations. J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Apr 1; 20(4):350-7. PMID: 10096579.
      View in: PubMed
    46. Jacobson M, Wilson S, Stanley H, Holtzer C, Cherrington J, Safrin S. Phase I study of combination therapy with intravenous cidofovir and oral ganciclovir for cytomegalovirus retinitis in patients with AIDS. Clin Infect Dis. 1999 Mar; 28(3):528-33. PMID: 10194072.
      View in: PubMed
    47. Jacobson M. Editorial comment: when to discontinue maintenance therapy for OIs in patients on HAART. AIDS Read. 1999 Mar-Apr; 9(2):124. PMID: 12728895.
      View in: PubMed
    48. Robles R, Lugo D, Gee L, Jacobson M. Effect of antiviral drugs used to treat cytomegalovirus end-organ disease on subsequent course of previously diagnosed Kaposi's sarcoma in patients with AIDS. J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Jan 1; 20(1):34-8. PMID: 9928727.
      View in: PubMed
    49. Aberg JA, Yajko DM, Jacobson M. Eradication of AIDS-related disseminated mycobacterium avium complex infection after 12 months of antimycobacterial therapy combined with highly active antiretroviral therapy. J Infect Dis. 1998 Nov; 178(5):1446-9. PMID: 9780266.
      View in: PubMed
    50. Gambertoglio J, Kumar P, Dieterich D, Jacobson M. Absence of effect of glutamic acid hydrochloride on the bioavailability of oral ganciclovir in AIDS patients with cytomegalovirus disease. J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Aug 1; 18(4):394-6. PMID: 9704949.
      View in: PubMed
    51. Komanduri KV, Viswanathan MN, Wieder ED, Schmidt DK, Bredt BM, Jacobson M, McCune JM. Restoration of cytomegalovirus-specific CD4+ T-lymphocyte responses after ganciclovir and highly active antiretroviral therapy in individuals infected with HIV-1. Nat Med. 1998 Aug; 4(8):953-6. PMID: 9701250.
      View in: PubMed
    52. Whitley RJ, Jacobson M, Friedberg DN, Holland GN, Jabs DA, Dieterich DT, Hardy WD, Polis MA, Deutsch TA, Feinberg J, Spector SA, Walmsley S, Drew WL, Powderly WG, Griffiths PD, Benson CA, Kessler HA. Guidelines for the treatment of cytomegalovirus diseases in patients with AIDS in the era of potent antiretroviral therapy: recommendations of an international panel. International AIDS Society-USA. Arch Intern Med. 1998 May 11; 158(9):957-69. PMID: 9588429.
      View in: PubMed
    53. Jacobson M. AIDS-related cytomegalovirus retinitis. Drugs Today (Barc). 1998 May; 34(5):409-13. PMID: 15010704.
      View in: PubMed
    54. Zegans ME, Walton RC, Holland GN, O'Donnell JJ, Jacobson M, Margolis TP. Transient vitreous inflammatory reactions associated with combination antiretroviral therapy in patients with AIDS and cytomegalovirus retinitis. Am J Ophthalmol. 1998 Mar; 125(3):292-300. PMID: 9512145.
      View in: PubMed
    55. Kuritzkes DR, Parenti D, Ward DJ, Rachlis A, Wong RJ, Mallon KP, Rich WJ, Jacobson M. Filgrastim prevents severe neutropenia and reduces infective morbidity in patients with advanced HIV infection: results of a randomized, multicenter, controlled trial. G-CSF 930101 Study Group. AIDS. 1998 Jan 1; 12(1):65-74. PMID: 9456256.
      View in: PubMed
    56. Jacobson M, French M. Altered natural history of AIDS-related opportunistic infections in the era of potent combination antiretroviral therapy. AIDS. 1998; 12 Suppl A:S157-63. PMID: 9632998.
      View in: PubMed
    57. Feinberg JE, Hurwitz S, Cooper D, Sattler FR, MacGregor RR, Powderly W, Holland GN, Griffiths PD, Pollard RB, Youle M, Gill MJ, Holland FJ, Power ME, Owens S, Coakley D, Fry J, Jacobson M. A randomized, double-blind trial of valaciclovir prophylaxis for cytomegalovirus disease in patients with advanced human immunodeficiency virus infection. AIDS Clinical Trials Group Protocol 204/Glaxo Wellcome 123-014 International CMV Prophylaxis Study Group. J Infect Dis. 1998 Jan; 177(1):48-56. PMID: 9419169.
      View in: PubMed
    58. Jacobson M. Ganciclovir therapy for severe cytomegalovirus infection in immunocompetent patients. Clin Infect Dis. 1997 Dec; 25(6):1487-8. PMID: 9431412.
      View in: PubMed
    59. Fredricks DN, Rojanasthien N, Jacobson M. AIDS-related disseminated histoplasmosis in San Francisco, California. West J Med. 1997 Nov; 167(5):315-21. PMID: 9392979; PMCID: PMC1304617.
    60. Jacobson M, Liu RC, Davies D, Cohen PT. Human immunodeficiency virus disease-related neutropenia and the risk of hospitalization for bacterial infection. Arch Intern Med. 1997 Sep 8; 157(16):1825-31. PMID: 9290541.
      View in: PubMed
    61. Holtzer CD, Stanley HD, Jacobson M. Severe reversible thrombocytopenia caused by recombinant human granulocyte colony-stimulating factor in an AIDS patient receiving chronic ganciclovir therapy. AIDS. 1997 Sep; 11(11):1403-5. PMID: 9302457.
      View in: PubMed
    62. Jacobson M. Treatment of cytomegalovirus retinitis in patients with the acquired immunodeficiency syndrome. N Engl J Med. 1997 Jul 10; 337(2):105-14. PMID: 9211681.
      View in: PubMed
    63. Jacobson M, Zegans M, Pavan PR, O'Donnell JJ, Sattler F, Rao N, Owens S, Pollard R. Cytomegalovirus retinitis after initiation of highly active antiretroviral therapy. Lancet. 1997 May 17; 349(9063):1443-5. PMID: 9164318.
      View in: PubMed
    64. Mueller AJ, Jacobson M, Hurwitz S, Chuang EL, Friedberg DN, Haidt SJ, Heinemann MH, Jabs DA, Kaplan HJ, Freeman WR. Re-evaluation of time to progression of foscarnet salvage therapy for cytomegalovirus retinitis in AIDS patients clinically resistant to ganciclovir. AIDS. 1997 Mar; 11(3):397-9. PMID: 9147441.
      View in: PubMed
    65. Kohl S, Sigaroudinia M, Charlebois ED, Jacobson M. Interleukin-12 administered in vivo decreases human NK cell cytotoxicity and antibody-dependent cellular cytotoxicity to human immunodeficiency virus-infected cells. J Infect Dis. 1996 Nov; 174(5):1105-8. PMID: 8896517.
      View in: PubMed
    66. Marra CM, Gary DW, Kuypers J, Jacobson M. Diagnosis of neurosyphilis in patients infected with human immunodeficiency virus type 1. J Infect Dis. 1996 Jul; 174(1):219-21. PMID: 8655999.
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    67. Harb GE, Mandema JW, Delahunty T, Benowitz NB, Coleman R, Sheiner LB, Jacobson M. Population pharmacokinetics of didanosine in patients with human immunodeficiency virus infection. J Infect Dis. 1996 Jan; 173(1):273. PMID: 8537676.
      View in: PubMed
    68. Jacobson M. Current management of cytomegalovirus retinitis in AIDS update on ganciclovir and foscarnet for CMV infections. Adv Exp Med Biol. 1996; 394:85-92. PMID: 8815712.
      View in: PubMed
    69. Jacobson M, Gundacker H, Hughes M, Fischl M, Volberding P. Zidovudine side effects as reported by black, Hispanic, and white/non-Hispanic patients with early HIV disease: combined analysis of two multicenter placebo-controlled trials. J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jan 1; 11(1):45-52. PMID: 8528732.
      View in: PubMed
    70. Jacobson M, De Gruttola V, Reddy M, Arduino JM, Strickland S, Reichman RC, Bartlett JA, Phair JP, Hirsch MS, Collier AC. The predictive value of changes in serologic and cell markers of HIV activity for subsequent clinical outcome in patients with asymptomatic HIV disease treated with zidovudine. AIDS. 1995 Jul; 9(7):727-34. PMID: 7546418.
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    71. Spector SA, Busch DF, Follansbee S, Squires K, Lalezari JP, Jacobson M, Connor JD, Jung D, Shadman A, Mastre B. Pharmacokinetic, safety, and antiviral profiles of oral ganciclovir in persons infected with human immunodeficiency virus: a phase I/II study. AIDS Clinical Trials Group, and Cytomegalovirus Cooperative Study Group. J Infect Dis. 1995 Jun; 171(6):1431-7. PMID: 7769276.
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    72. Holland GN, Levinson RD, Jacobson M. Dose-related difference in progression rates of cytomegalovirus retinopathy during foscarnet maintenance therapy. AIDS Clinical Trials Group Protocol 915 Team. Am J Ophthalmol. 1995 May; 119(5):576-86. PMID: 7733183.
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    73. Aweeka FT, Gambertoglio JG, Kramer F, van der Horst C, Polsky B, Jayewardene A, Lizak P, Emrick L, Tong W, Jacobson M. Foscarnet and ganciclovir pharmacokinetics during concomitant or alternating maintenance therapy for AIDS-related cytomegalovirus retinitis. Clin Pharmacol Ther. 1995 Apr; 57(4):403-12. PMID: 7712668.
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    74. Jacobson M. Update (1995) on clinical trials of antiviral therapy and prophylaxis for AIDS-related cytomegalovirus disease. Scand J Infect Dis Suppl. 1995; 99:96-9. PMID: 8668951.
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    75. Flexner C, van der Horst C, Jacobson M, Powderly W, Duncanson F, Ganes D, Barditch-Crovo PA, Petty BG, Baron PA, Armstrong D. Relationship between plasma concentrations of 3'-deoxy-3'-fluorothymidine (alovudine) and antiretroviral activity in two concentration-controlled trials. J Infect Dis. 1994 Dec; 170(6):1394-403. PMID: 7995977.
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    76. Burack JH, Hahn JA, Saint-Maurice D, Jacobson M. Microbiology of community-acquired bacterial pneumonia in persons with and at risk for human immunodeficiency virus type 1 infection. Implications for rational empiric antibiotic therapy. Arch Intern Med. 1994 Nov 28; 154(22):2589-96. PMID: 7979856.
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    77. Jacobson M. Current management of cytomegalovirus disease in patients with AIDS. AIDS Res Hum Retroviruses. 1994 Aug; 10(8):917-23. PMID: 7811543.
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    78. Jacobson M, Kramer F, Bassiakos Y, Hooton T, Polsky B, Geheb H, O'Donnell JJ, Walker JD, Korvick JA, van der Horst C. Randomized phase I trial of two different combination foscarnet and ganciclovir chronic maintenance therapy regimens for AIDS patients with cytomegalovirus retinitis: AIDS clinical Trials Group Protocol 151. J Infect Dis. 1994 Jul; 170(1):189-93. PMID: 8014496.
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    79. Jacobson M, Gallant J, Wang LH, Coakley D, Weller S, Gary D, Squires L, Smiley ML, Blum MR, Feinberg J. Phase I trial of valaciclovir, the L-valyl ester of acyclovir, in patients with advanced human immunodeficiency virus disease. Antimicrob Agents Chemother. 1994 Jul; 38(7):1534-40. PMID: 7979285; PMCID: PMC284589.
    80. Jacobson M, Polsky B, Causey D, Davis R, Tong W, O'Donnell JJ, Kuppermann BD, Heinemann MH, Feinberg J, Lizak P. Pharmacodynamic relationship of pharmacokinetic parameters of maintenance doses of foscarnet and clinical outcome of cytomegalovirus retinitis. Antimicrob Agents Chemother. 1994 May; 38(5):1190-3. PMID: 8067763; PMCID: PMC188177.
    81. Jacobson M, Wulfsohn M, Feinberg JE, Davis R, Power M, Owens S, Causey D, Heath-Chiozzi ME, Murphy RL, Cheung TW. Phase II dose-ranging trial of foscarnet salvage therapy for cytomegalovirus retinitis in AIDS patients intolerant of or resistant to ganciclovir (ACTG protocol 093). AIDS Clinical Trials Group of the National Institute of Allergy and Infectious Diseases. AIDS. 1994 Apr; 8(4):451-9. PMID: 8011248.
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    82. Stanley HD, Charlebois E, Harb G, Jacobson M. Central venous catheter infections in AIDS patients receiving treatment for cytomegalovirus disease. J Acquir Immune Defic Syndr. 1994 Mar; 7(3):272-8. PMID: 8106966.
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    83. Jacobson M, Besch CL, Child C, Hafner R, Matts JP, Muth K, Wentworth DN, Neaton JD, Abrams D, Rimland D. Primary prophylaxis with pyrimethamine for toxoplasmic encephalitis in patients with advanced human immunodeficiency virus disease: results of a randomized trial. Terry Beirn Community Programs for Clinical Research on AIDS. J Infect Dis. 1994 Feb; 169(2):384-94. PMID: 8106772.
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    84. Chin DP, Hopewell PC, Yajko DM, Vittinghoff E, Horsburgh CR, Hadley WK, Stone EN, Nassos PS, Ostroff SM, Jacobson M. Mycobacterium avium complex in the respiratory or gastrointestinal tract and the risk of M. avium complex bacteremia in patients with human immunodeficiency virus infection. J Infect Dis. 1994 Feb; 169(2):289-95. PMID: 7906290.
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    85. Jacobson M, Causey D, Polsky B, Hardy D, Chown M, Davis R, O'Donnell JJ, Kuppermann BD, Heinemann MH, Holland GN. A dose-ranging study of daily maintenance intravenous foscarnet therapy for cytomegalovirus retinitis in AIDS. J Infect Dis. 1993 Aug; 168(2):444-8. PMID: 8393058.
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    86. Harb GE, Alldredge BK, Coleman R, Jacobson M. Pharmacoepidemiology of adverse drug reactions in hospitalized patients with human immunodeficiency virus disease. J Acquir Immune Defic Syndr. 1993 Aug; 6(8):919-26. PMID: 8315576.
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    87. Jacobson M, Yajko D, Northfelt D, Charlebois E, Gary D, Brosgart C, Sanders CA, Hadley WK. Randomized, placebo-controlled trial of rifampin, ethambutol, and ciprofloxacin for AIDS patients with disseminated Mycobacterium avium complex infection. J Infect Dis. 1993 Jul; 168(1):112-9. PMID: 8515098.
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    88. Harb GE, Jacobson M. Human immunodeficiency virus (HIV) infection. Does it increase susceptibility to adverse drug reactions? Drug Saf. 1993 Jul; 9(1):1-8. PMID: 8347288.
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    89. Dyner TS, Lang W, Geaga J, Golub A, Stites D, Winger E, Galmarini M, Masterson J, Jacobson M. An open-label dose-escalation trial of oral dehydroepiandrosterone tolerance and pharmacokinetics in patients with HIV disease. J Acquir Immune Defic Syndr. 1993 May; 6(5):459-65. PMID: 8097787.
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    90. Jacobson M, Owen W, Campbell J, Brosgart C, Abrams DI. Tolerability of combined ganciclovir and didanosine for the treatment of cytomegalovirus disease associated with AIDS. Clin Infect Dis. 1993 Feb; 16 Suppl 1:S69-73. PMID: 8381032.
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    91. Jacobson M. Valaciclovir (BW256U87): the L-valyl ester of acyclovir. J Med Virol. 1993; Suppl 1:150-3. PMID: 8245883.
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    92. Bayard PJ, Berger TG, Jacobson M. Drug hypersensitivity reactions and human immunodeficiency virus disease. J Acquir Immune Defic Syndr. 1992 Dec; 5(12):1237-57. PMID: 1453334.
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    93. Reddy MM, Grieco MH, McKinley GF, Causey DM, van der Horst CM, Parenti DM, Hooton TM, Davis RB, Jacobson M. Effect of foscarnet therapy on human immunodeficiency virus p24 antigen levels in AIDS patients with cytomegalovirus retinitis. J Infect Dis. 1992 Sep; 166(3):607-10. PMID: 1323624.
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    94. Aweeka FT, Gambertoglio JG, van der Horst C, Raasch R, Jacobson M. Pharmacokinetics of concomitantly administered foscarnet and zidovudine for treatment of human immunodeficiency virus infection (AIDS Clinical Trials Group protocol 053). Antimicrob Agents Chemother. 1992 Aug; 36(8):1773-8. PMID: 1416864; PMCID: PMC192046.
    95. Jacobson M, Stanley HD, Heard SE. Ganciclovir with recombinant methionyl human granulocyte colony-stimulating factor for treatment of cytomegalovirus disease in AIDS patients. AIDS. 1992 May; 6(5):515-7. PMID: 1377475.
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    96. Jacobson M. Maintenance therapy for cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome: foscarnet. Am J Med. 1992 Feb 14; 92(2A):26S-29S. PMID: 1310573.
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    97. Jacobson M, Besch CL, Child C, Hafner R, Matts JP, Muth K, Wentworth DN, Deyton L. Toxicity of clindamycin as prophylaxis for AIDS-associated toxoplasmic encephalitis. Community Programs for Clinical Research on AIDS. Lancet. 1992 Feb 8; 339(8789):333-4. PMID: 1346413.
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    98. Bacchetti P, Moss AR, Andrews JC, Jacobson M. Early predictors of survival in symptomatic HIV-infected persons treated with high-dose zidovudine. J Acquir Immune Defic Syndr. 1992; 5(7):732-6. PMID: 1535375.
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    99. Jacobson M. Review of the toxicities of foscarnet. J Acquir Immune Defic Syndr. 1992; 5 Suppl 1:S11-7. PMID: 1534839.
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    100. Jacobson M, Hopewell PC, Yajko DM, Hadley WK, Lazarus E, Mohanty PK, Modin GW, Feigal DW, Cusick PS, Sande MA. Natural history of disseminated Mycobacterium avium complex infection in AIDS. J Infect Dis. 1991 Nov; 164(5):994-8. PMID: 1682396.
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    101. Jacobson M, Fusaro RE, Galmarini M, Lang W. Decreased serum dehydroepiandrosterone is associated with an increased progression of human immunodeficiency virus infection in men with CD4 cell counts of 200-499. J Infect Dis. 1991 Nov; 164(5):864-8. PMID: 1682393.
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    102. Harb GE, Bacchetti P, Jacobson M. Survival of patients with AIDS and cytomegalovirus disease treated with ganciclovir or foscarnet. AIDS. 1991 Aug; 5(8):959-65. PMID: 1663770.
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    103. Jacobson M, Mills J, Rush J, Peiperl L, Seru V, Mohanty PK, Hopewell PC, Hadley WK, Broadus VC, Leoung G. Morbidity and mortality of patients with AIDS and first-episode Pneumocystis carinii pneumonia unaffected by concomitant pulmonary cytomegalovirus infection. Am Rev Respir Dis. 1991 Jul; 144(1):6-9. PMID: 1648316.
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    104. Jacobson M, Drew WL, Feinberg J, O'Donnell JJ, Whitmore PV, Miner RD, Parenti D. Foscarnet therapy for ganciclovir-resistant cytomegalovirus retinitis in patients with AIDS. J Infect Dis. 1991 Jun; 163(6):1348-51. PMID: 1645385.
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    105. Jacobson M, Gambertoglio JG, Aweeka FT, Causey DM, Portale AA. Foscarnet-induced hypocalcemia and effects of foscarnet on calcium metabolism. J Clin Endocrinol Metab. 1991 May; 72(5):1130-5. PMID: 1827127.
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    106. Jacobson M, Besch CL, Child C, Hafner R, Muth K, Deyton L. Clinical programs for clinical research on AIDS: description of a randomized prospective study of clindamycin versus pyrimethamine for prevention of Toxoplasma gondii infection. Eur J Clin Microbiol Infect Dis. 1991 Mar; 10(3):195-8. PMID: 1676364.
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    107. Jacobson M, Bacchetti P, Kolokathis A, Chaisson RE, Szabo S, Polsky B, Valainis GT, Mildvan D, Abrams D, Wilber J. Surrogate markers for survival in patients with AIDS and AIDS related complex treated with zidovudine. BMJ. 1991 Jan 12; 302(6768):73-8. PMID: 1671651; PMCID: PMC1668875.
    108. Jacobson M, O'Donnell JJ. Approaches to the treatment of cytomegalovirus retinitis: ganciclovir and foscarnet. J Acquir Immune Defic Syndr. 1991; 4 Suppl 1:S11-5. PMID: 1848616.
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    109. Wilcox CM, Diehl DL, Cello JP, Margaretten W, Jacobson M. Cytomegalovirus esophagitis in patients with AIDS. A clinical, endoscopic, and pathologic correlation. Ann Intern Med. 1990 Oct 15; 113(8):589-93. PMID: 2169217.
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    110. Wilcox CM, Byford BA, Forsmark CE, Hadley WK, Cello JP, Jacobson M. Campylobacter-like organisms are uncommon pathogens in patients infected with the human immunodeficiency virus. J Clin Microbiol. 1990 Oct; 28(10):2370-1. PMID: 2229366; PMCID: PMC268182.
    111. Leoung GS, Feigal DW, Montgomery AB, Corkery K, Wardlaw L, Adams M, Busch D, Gordon S, Jacobson M, Volberding PA. Aerosolized pentamidine for prophylaxis against Pneumocystis carinii pneumonia. The San Francisco community prophylaxis trial. N Engl J Med. 1990 Sep 20; 323(12):769-75. PMID: 1975426.
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    112. Farese RV, Schambelan M, Hollander H, Stringari S, Jacobson M. Nephrogenic diabetes insipidus associated with foscarnet treatment of cytomegalovirus retinitis. Ann Intern Med. 1990 Jun 15; 112(12):955-6. PMID: 2160217.
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    113. Jacobson M, Peiperl L, Volberding PA, Porteous D, Toy PT, Feigal D. Red cell transfusion therapy for anemia in patients with AIDS and ARC: incidence, associated factors, and outcome. Transfusion. 1990 Feb; 30(2):133-7. PMID: 2305441.
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    114. Hassanzadeh MK, Aweeka FT, Wu S, Jacobson M, Gambertoglio JG. Determination of phosphonoformic acid in human plasma and urine by high-performance liquid chromatography with electrochemical detection. J Chromatogr. 1990 Jan 26; 525(1):133-40. PMID: 2140113.
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    115. Jacobson M, O'Donnell JJ, Rousell R, Dionian B, Mills J. Failure of adjunctive cytomegalovirus intravenous immune globulin to improve efficacy of ganciclovir in patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis: a phase 1 study. Antimicrob Agents Chemother. 1990 Jan; 34(1):176-8. PMID: 2158273; PMCID: PMC171546.
    116. Jacobson M, Abrams DI, Volberding PA, Bacchetti P, Wilber J, Chaisson RE, Crowe S, Howard W, Moss A. Serum beta 2-microglobulin decreases in patients with AIDS or ARC treated with azidothymidine. J Infect Dis. 1989 Jun; 159(6):1029-36. PMID: 2566637.
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    117. Jacobson M, O'Donnell JJ, Mills J. Foscarnet treatment of cytomegalovirus retinitis in patients with the acquired immunodeficiency syndrome. Antimicrob Agents Chemother. 1989 May; 33(5):736-41. PMID: 2546490; PMCID: PMC172524.
    118. Erlich KS, Jacobson M, Koehler JE, Follansbee SE, Drennan DP, Gooze L, Safrin S, Mills J. Foscarnet therapy for severe acyclovir-resistant herpes simplex virus type-2 infections in patients with the acquired immunodeficiency syndrome (AIDS). An uncontrolled trial. Ann Intern Med. 1989 May 1; 110(9):710-3. PMID: 2522751.
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    119. Aweeka F, Gambertoglio J, Mills J, Jacobson M. Pharmacokinetics of intermittently administered intravenous foscarnet in the treatment of acquired immunodeficiency syndrome patients with serious cytomegalovirus retinitis. Antimicrob Agents Chemother. 1989 May; 33(5):742-5. PMID: 2546491; PMCID: PMC172525.
    120. Small PM, McPhaul LW, Sooy CD, Wofsy CB, Jacobson M. Cytomegalovirus infection of the laryngeal nerve presenting as hoarseness in patients with acquired immunodeficiency syndrome. Am J Med. 1989 Jan; 86(1):108-10. PMID: 2535917.
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    121. Jacobson M, McGrath MS, Joseph P, Molaghan JB, Tadepalli S, Quinn R. Zidovudine-induced fever. J Acquir Immune Defic Syndr. 1989; 2(4):382-8. PMID: 2666640.
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    122. O'Donnell JJ, Jacobson M. Cotton-wool spots and cytomegalovirus retinitis in AIDS. Int Ophthalmol Clin. 1989; 29(2):105-7. PMID: 2541095.
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    123. Jacobson M, Mills J, Rush J, O'Donnell JJ, Miller RG, Greco C, Gonzales MF. Failure of antiviral therapy for acquired immunodeficiency syndrome-related cytomegalovirus myelitis. Arch Neurol. 1988 Oct; 45(10):1090-2. PMID: 2845899.
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    124. Jacobson M, Crowe S, Levy J, Aweeka F, Gambertoglio J, McManus N, Mills J. Effect of Foscarnet therapy on infection with human immunodeficiency virus in patients with AIDS. J Infect Dis. 1988 Oct; 158(4):862-5. PMID: 2844921.
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    125. Jacobson M, de Miranda P, Gordon SM, Blum MR, Volberding P, Mills J. Prolonged pancytopenia due to combined ganciclovir and zidovudine therapy. J Infect Dis. 1988 Aug; 158(2):489-90. PMID: 3261316.
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    126. Jacobson M, Gellermann H, Chambers H. Staphylococcus aureus bacteremia and recurrent staphylococcal infection in patients with acquired immunodeficiency syndrome and AIDS-related complex. Am J Med. 1988 Aug; 85(2):172-6. PMID: 3400693.
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    127. Jacobson M, O'Donnell JJ, Brodie HR, Wofsy C, Mills J. Randomized prospective trial of ganciclovir maintenance therapy for cytomegalovirus retinitis. J Med Virol. 1988 Jul; 25(3):339-49. PMID: 2844981.
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    128. Mills J, Jacobson M, O'Donnell JJ, Cederberg D, Holland GN. Treatment of cytomegalovirus retinitis in patients with AIDS. Rev Infect Dis. 1988 Jul-Aug; 10 Suppl 3:S522-31. PMID: 2847289.
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    129. Ng VL, Jacobson M, Khayam-Bashi H, McGrath MS. Lymphoma in an HIV-positive man after disappearance of a paraprotein. N Engl J Med. 1988 Jun 30; 318(26):1761. PMID: 3259675.
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    130. Jacobson M, O'Donnell JJ, Porteous D, Brodie HR, Feigal D, Mills J. Retinal and gastrointestinal disease due to cytomegalovirus in patients with the acquired immune deficiency syndrome: prevalence, natural history, and response to ganciclovir therapy. Q J Med. 1988 Jun; 67(254):473-86. PMID: 2854894.
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    131. Jacobson M, Mills J. Serious cytomegalovirus disease in the acquired immunodeficiency syndrome (AIDS). Clinical findings, diagnosis, and treatment. Ann Intern Med. 1988 Apr; 108(4):585-94. PMID: 2831765.
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    132. Jacobson M, Cello JP, Sande MA. Cholestasis and disseminated cytomegalovirus disease in patients with the acquired immunodeficiency syndrome. Am J Med. 1988 Feb; 84(2):218-24. PMID: 2841850.
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    133. Jacobson M, de Miranda P, Cederberg DM, Burnette T, Cobb E, Brodie HR, Mills J. Human pharmacokinetics and tolerance of oral ganciclovir. Antimicrob Agents Chemother. 1987 Aug; 31(8):1251-4. PMID: 2820301; PMCID: PMC174913.
    134. O'Donnell JJ, Jacobson M, Mills J. Development of cytomegalovirus (CMV) retinitis in a patient with AIDS during ganciclovir therapy of CMV colitis. N Engl J Med. 1987 Jun 18; 316(25):1607-8. PMID: 3035374.
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