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Celine Taglang, PhD

Title(s)Postdoctoral Scholar, Physical Therapy
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    University of California San Francisco, Department of Physical Therapy, San FranciscoPostdoctoral researchCurrentEvaluation of strategies to attenuate primary CNS lymphoma growth by testing promising agents
    University of California San Francisco, Department of Radiology and Biomedical Imaging, San FranciscoPostdoctoral research201913C labeling and hyperpolarization of biocompatible agents for MRI
    French Atomic Energy Commission - Paris Saclay University, Saclay, FrancePh.D in Organic Chemistry2015Enantiospecific C(sp3)-H activation catalyzed by ruthenium nanoparticles and isotopic labeling
    French Atomic Energy Commission - Paris Saclay University, Saclay, France2012Synthesis of chitosan NHC-N heterogeneous catalysts and study of their reactivity
    GlaxoSmithKline, Research Center, Les Ulis , Les Ulis, France2011Synthesis of anti-diabetic therapeutic molecules
    Sanofi, Medicinal Chemistry – Oncology, Vitry-sur-Seine, France2010Synthesis of kinase inhibitors
    Collapse Awards and Honors
    US Department of Defense Office of the Congressionally Directed Medical Research Programs2017  - 20192016 Prostate Cancer Research Program - Early Investigator Research Award
    French Atomic Energy Commission2012  - 2015IRTELIS-CEA PhD Program-Life Sciences Division

    Collapse Overview 
    Collapse Overview
    Post-doctoral researcher at UCSF, with a background in chemistry, working on 13C labeling and hyperpolarization of biocompatible agents for MRI with applications from enzymatic activity to animal models, my current research, in Chaumeil Lab, focuses on the evaluation of strategies to attenuate primary CNS lymphoma growth by testing promising agents with or without established therapies.

    I completed my PhD degree in 2015 at the Paris Saclay University, after three internships in organic and medicinal chemistry in two private companies (GSK, Sanofi) and one public institution (CEA). In the course of my trainings, I worked on the synthesis of anti-cancer and anti-diabetic therapeutic molecules and discovered my passion for Research in life sciences.

    During my PhD, my research focused on the enantiospecific C(sp3)-H activation followed by the deuterium incorporation onto stereogenic centers of small molecules. Using ruthenium nanoparticles, I applied this powerful and general method on 25 important chemical and biological compounds such as amines, aminoacids and small peptides. The mechanism of this fully stereoretentive process was investigated by a set of chemical experiments and DFT calculations which led to infer the reaction implied an unprecedented mechanism involving multiple ruthenium atoms and a s-complex-assisted metathesis.

    After these diverse experiences, I decided to join Dr. Wilson's lab at UCSF: in hyperpolarized 13C MRI, one of the fundamental limitations is the effective lifetime of the signal, called T1. I developed a robust late stage deuteration methodology, which is broadly applicable to amino, and a-hydroxyl acids, like alanine and lactate. Incorporation of deuterium in these substrates led to a significant T1 prolongation, ranging from 16-29% at a position adjacent to the 13C nucleus. Moreover, when applied to directly attached 13C nuclei, this led to a greater than 4 fold increase in T1. Most importantly, when applied to in vivo imaging, [1-13C,2-2H]alanine demonstrated a greater than doubling of effective signal to noise ratio. I was also working with Dr. Flavell's lab on molecular strategies to image the acidic tumoral microenvironment. For example, [2-13C,D10]diethylmalonic acid is a strong potential candidate for high spatial resolution in vivo pH mapping. Instead of using a ratiometric method, it uses differences in chemical shifts and allows for the detection of multiple pH compartments within the same voxel in mice kidneys imaging experiments.

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    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Wang S, Korenchan DE, Perez PM, Taglang C, Hayes TR, Sriram R, Bok R, Hong AS, Wu Y, Li H, Wang Z, Kurhanewicz J, Wilson DM, Flavell RR. Amino Acid-Derived Sensors for Specific Zn2+ Detection Using Hyperpolarized 13 C Magnetic Resonance Spectroscopy. Chemistry. 2019 Sep 12; 25(51):11842-11846. PMID: 31338914.
      View in: PubMed
    2. Taglang C, Korenchan DE, von Morze C, Yu J, Najac C, Wang S, Blecha JE, Subramaniam S, Bok R, VanBrocklin HF, Vigneron DB, Ronen SM, Sriram R, Kurhanewicz J, Wilson DM, Flavell RR. Late-stage deuteration of 13C-enriched substrates for T1 prolongation in hyperpolarized 13C MRI. Chem Commun (Camb). 2018 May 17; 54(41):5233-5236. PMID: 29726563.
      View in: PubMed
    3. Mutch CA, Ordonez AA, Qin H, Parker M, Bambarger LE, Villanueva-Meyer JE, Blecha J, Carroll V, Taglang C, Flavell R, Sriram R, VanBrocklin H, Rosenberg O, Ohliger MA, Jain SK, Neumann KD, Wilson DM. [11C]Para-Aminobenzoic Acid: A Positron Emission Tomography Tracer Targeting Bacteria-Specific Metabolism. ACS Infect Dis. 2018 07 13; 4(7):1067-1072. PMID: 29712422.
      View in: PubMed
    4. Gao L, Perato S, Garcia-Argote S, Taglang C, Martínez-Prieto LM, Chollet C, Buisson DA, Dauvois V, Lesot P, Chaudret B, Rousseau B, Feuillastre S, Pieters G. Ruthenium-catalyzed hydrogen isotope exchange of C(sp3)-H bonds directed by a sulfur atom. Chem Commun (Camb). 2018 Mar 25; 54(24):2986-2989. PMID: 29505052.
      View in: PubMed
    5. Korenchan DE, Taglang C, von Morze C, Blecha JE, Gordon JW, Sriram R, Larson PEZ, Vigneron DB, VanBrocklin HF, Kurhanewicz J, Wilson DM, Flavell RR. Dicarboxylic acids as pH sensors for hyperpolarized 13C magnetic resonance spectroscopic imaging. Analyst. 2017 May 02; 142(9):1429-1433. PMID: 28322385.
      View in: PubMed
    6. Taglang C, Martínez-Prieto LM, del Rosal I, Maron L, Poteau R, Philippot K, Chaudret B, Perato S, Sam Lone A, Puente C, Dugave C, Rousseau B, Pieters G. Enantiospecific C-H Activation Using Ruthenium Nanocatalysts. Angew Chem Int Ed Engl. 2015 Sep 01; 54(36):10474-7. PMID: 26371960.
      View in: PubMed
    7. Pieters G, Taglang C, Bonnefille E, Gutmann T, Puente C, Berthet JC, Dugave C, Chaudret B, Rousseau B. Regioselective and stereospecific deuteration of bioactive aza compounds by the use of ruthenium nanoparticles. Angew Chem Int Ed Engl. 2014 Jan 03; 53(1):230-4. PMID: 24254536.
      View in: PubMed