Celine Taglang, PhD

Title(s)Postdoctoral Scholar, Physical Therapy
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    University of California San Francisco, Department of Radiology and Biomedical Imaging, San FranciscoPostdoctoral researchCurrentDevelopment of new hyperpolarized 13C agents
    French Atomic Energy Commission - Paris Saclay University, Saclay, FrancePh.D in Organic Chemistry2015Enantiospecific C(sp3)-H activation catalyzed by ruthenium nanoparticles and isotopic labeling
    French Atomic Energy Commission - Paris Saclay University, Saclay, France2012Synthesis of chitosan NHC-N heterogeneous catalysts and study of their reactivity
    GlaxoSmithKline, Research Center, Les Ulis , Les Ulis, France2011Synthesis of anti-diabetic therapeutic molecules
    Sanofi, Medicinal Chemistry – Oncology, Vitry-sur-Seine, France2010Synthesis of kinase inhibitors
    Collapse Awards and Honors
    US Department of Defense Office of the Congressionally Directed Medical Research Programs2017  - 20192016 Prostate Cancer Research Program - Early Investigator Research Award
    French Atomic Energy Commission2012  - 2015IRTELIS-CEA PhD Program-Life Sciences Division

    Collapse Overview 
    Collapse Overview
    During my graduate work at Paris-Sud University, I learned an exceptional amount of chemistry and physics as part of my thesis project. Activation of C-H bonds and conversion to C-C or C-X bonds has revolutionized modern synthetic chemistry. My research focused on a smooth, selective (in a position relative to nitrogen of amines) and enantiospecific C(sp3)-H activation method followed by deuterium incorporation onto stereogenic centers using 1.1 nm ruthenium nanoparticles. This powerful and general method was applied on 25 important chemical and biological compounds such as amines, amino acids and peptides. Those deuterium labeled compounds are crucial and promising targets for numerous applications such as: drug metabolism and toxicity studies, metabolomics, material chemistry and the determination of chemical mechanisms. The methods that I developed are highly relevant to hyperpolarized 13C spectroscopy, an emerging diagnostic method with tremendous potential in the treatment of prostate cancer patients.
    I joined UCSF to strengthen my training in biomarker and drug development by taking on a project that focused on developing new hyperpolarized 13C agents, applying them to prostate cancer, and establishing their potential for near-term clinical translation. I chose to work on prostate cancer, owing to the established role of nuclear imaging and medicine in standard of care. Moreover, beyond Dr. Wilson’s, Dr. Flavell’s and Pr. Kurhanewicz’s expertise in prostate cancer imaging, treatment and biology, the excellent research and clinical environment made UCSF an obvious choice to conduct my postdoctoral training.

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Taglang C, Korenchan DE, von Morze C, Yu J, Najac C, Wang S, Blecha JE, Subramaniam S, Bok R, VanBrocklin HF, Vigneron DB, Ronen SM, Sriram R, Kurhanewicz J, Wilson DM, Flavell RR. Late-stage deuteration of 13C-enriched substrates for T1 prolongation in hyperpolarized 13C MRI. Chem Commun (Camb). 2018 May 17; 54(41):5233-5236. PMID: 29726563.
      View in: PubMed
    2. Mutch CA, Ordonez AA, Qin H, Parker M, Bambarger LE, Villanueva-Meyer JE, Blecha J, Carroll V, Taglang C, Flavell R, Sriram R, VanBrocklin H, Rosenberg O, Ohliger MA, Jain SK, Neumann KD, Wilson DM. [11C]Para-Aminobenzoic Acid: A Positron Emission Tomography Tracer Targeting Bacteria-Specific Metabolism. ACS Infect Dis. 2018 07 13; 4(7):1067-1072. PMID: 29712422.
      View in: PubMed
    3. Gao L, Perato S, Garcia-Argote S, Taglang C, Martínez-Prieto LM, Chollet C, Buisson DA, Dauvois V, Lesot P, Chaudret B, Rousseau B, Feuillastre S, Pieters G. Ruthenium-catalyzed hydrogen isotope exchange of C(sp3)-H bonds directed by a sulfur atom. Chem Commun (Camb). 2018 Mar 25; 54(24):2986-2989. PMID: 29505052.
      View in: PubMed
    4. Korenchan DE, Taglang C, von Morze C, Blecha JE, Gordon JW, Sriram R, Larson PEZ, Vigneron DB, VanBrocklin HF, Kurhanewicz J, Wilson DM, Flavell RR. Dicarboxylic acids as pH sensors for hyperpolarized 13C magnetic resonance spectroscopic imaging. Analyst. 2017 May 02; 142(9):1429-1433. PMID: 28322385.
      View in: PubMed
    5. Taglang C, Martínez-Prieto LM, del Rosal I, Maron L, Poteau R, Philippot K, Chaudret B, Perato S, Sam Lone A, Puente C, Dugave C, Rousseau B, Pieters G. Enantiospecific C-H Activation Using Ruthenium Nanocatalysts. Angew Chem Int Ed Engl. 2015 Sep 01; 54(36):10474-7. PMID: 26371960.
      View in: PubMed
    6. Pieters G, Taglang C, Bonnefille E, Gutmann T, Puente C, Berthet JC, Dugave C, Chaudret B, Rousseau B. Regioselective and stereospecific deuteration of bioactive aza compounds by the use of ruthenium nanoparticles. Angew Chem Int Ed Engl. 2014 Jan 03; 53(1):230-4. PMID: 24254536.
      View in: PubMed