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Michael Ohliger, MD, PhD

TitleAssociate Professor
InstitutionUniversity of California San Francisco
DepartmentRadiology
Address1001 Potrero Ave
San Francisco CA 94110
Phone415-206-8024
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    Collapse Biography 
    Collapse Education and Training
    University of Calufornia, San FranciscoFellowship2013Abdominal Imaging
    University of California, San FranciscoResidency 2012Radiology
    Harvard Medical SchoolMD2007Medicine
    Massachusetts Institute of TrchnologyPhD2005Medical Physics
    Collapse Awards and Honors
    Radiological Society of North America2014  - 2016Research Scholar Award
    Radiological Society of North America 2011Cum Laude Award
    Radiological Society of North America 2011Molecular Imaging Travel Award
    Beth Israel Deaconess Medical Center Department of Radiology, Boston, MA2005Fleischner Research Award

    Collapse Overview 
    Collapse Overview
    Michael Ohliger, MD, PhD, is an Associate Professor in Residence in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. Dr. Ohliger obtained his PhD in Medical Physics from the Massachusetts Institute of Technology Harvard/MIT Division of Health Sciences and Technology in 2005, and he received his MD in Medicine from Harvard Medical School in Cambridge, Massachusetts in 2007. He completed his residency in Diagnostic Radiology from UCSF in 2012, followed by a fellowship in Abdominal Imaging from UCSF in 2013. He accepted the position of Assistant Professor in Residence at UCSF and SFGH, in July 2013.

    Dr. Ohliger’s main research interest is the development and clinical translation of new MRI techniques for the abdomen and pelvis, with a focus on molecular imaging with hyperpolarized carbon-13 compounds. His active research projects include the development of hyperpolarized 13C methods for detecting liver injury as well as developing novel methods for assessing liver tumors. Dr. Ohliger also has a major research effort (together with Dr. David Wilson and Oren Rosenberg) developing novel methods for imaging bacterial injection.



    Expertise:
    Abdominal Imaging

    Specialty:
    Abdomen and pelvis

    Professional Interests:
    Cancer, abdominal imaging, genitourinary imaging, magnetic resonance imaging, physics, radiation, molecular imaging, hyperpolarized carbon, nuclear magnetic resonance, liver, kidney, prostate, bowel

    Education and Training:
    • Medical School: Harvard Medical School, Boston, Massachusetts - Medicine
    • Internship: Brigham and Women’s Hospital, Boston, Massachusetts - Medicine
    • Residency: University of California, San Francisco - Diagnostic Radiology
    • Fellowship: University of California, San Francisco - Abdominal Imaging
    • Doctor of Philosophy: Massachusetts Institute of Technology Harvard/MIT, Boston, Division of Health Sciences and Technology - Medical Physics
    • California Physician and Surgeon License
    • California X-ray Supervisor and Operator Certificate
    • American Board of Radiology Certificate in Diagnostic Radiology


    Collapse Research 
    Collapse Research Activities and Funding
    Clinical translation of D-amino acid derived PET tracers for imaging spinalinfection
    NIH/NIBIB R01EB024014Sep 20, 2017 - Jun 30, 2021
    Role: Co-Principal Investigator
    Exploring combined hyperpolarized 13C MRI with liver-specific gadolinium contrast agents for improved metabolic assessment of liver tumors
    NIH R21EB023605Aug 1, 2017 - May 31, 2019
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse Featured Presentations

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Yeh BM, Obmann MM, Westphalen AC, Ohliger MA, Yee J, Sun Y, Wang ZJ. Dual Energy Computed Tomography Scans of the Bowel: Benefits, Pitfalls, and Future Directions. Radiol Clin North Am. 2018 Sep; 56(5):805-819. PMID: 30119775.
      View in: PubMed
    2. Bailey JJ, Jordan EJ, Burke C, Ohliger MA, Wang ZJ, Loon KV, Varma MG, Hope TA. Does Extended PET Acquisition in PET/MRI Rectal Cancer Staging Improve Results? AJR Am J Roentgenol. 2018 Aug 14; 1-5. PMID: 30106609.
      View in: PubMed
    3. Wang ZJ, Behr S, Consunji MV, Yeh BM, Ohliger MA, Gao K, Ko AH, Cinar P, Tempero MA, Collisson EA. Early Response Assessment in Pancreatic Ductal Adenocarcinoma Through Integrated PET/MRI. AJR Am J Roentgenol. 2018 Jul 31; 1-10. PMID: 30063366.
      View in: PubMed
    4. Mutch CA, Ordonez AA, Qin H, Parker M, Bambarger LE, Villanueva-Meyer JE, Blecha J, Carroll V, Taglang C, Flavell R, Sriram R, VanBrocklin H, Rosenberg O, Ohliger MA, Jain SK, Neumann KD, Wilson DM. [11C]Para-Aminobenzoic Acid: A Positron Emission Tomography Tracer Targeting Bacteria-Specific Metabolism. ACS Infect Dis. 2018 May 08. PMID: 29712422.
      View in: PubMed
    5. Hicks RM, Loening AM, Ohliger MA, Vasanawala SS, Hope TA. Variable refocusing flip angle single-shot fast spin echo imaging of liver lesions: increased speed and lesion contrast. Abdom Radiol (NY). 2018 Mar; 43(3):593-599. PMID: 28689221.
      View in: PubMed
    6. von Morze C, Reed GD, Larson PE, Mammoli D, Chen AP, Tropp J, Van Criekinge M, Ohliger MA, Kurhanewicz J, Vigneron DB, Merritt ME. In vivo hyperpolarization transfer in a clinical MRI scanner. Magn Reson Med. 2018 Feb 27. PMID: 29488244.
      View in: PubMed
    7. Sriram R, Sun J, Villanueva-Meyer J, Mutch C, De Los Santos J, Peters J, Korenchan DE, Neumann K, Van Criekinge M, Kurhanewicz J, Rosenberg O, Wilson D, Ohliger MA. Detection of Bacteria-Specific Metabolism Using Hyperpolarized [2-13C]Pyruvate. ACS Infect Dis. 2018 Feb 13. PMID: 29405697.
      View in: PubMed
    8. Morze CV, Allu PKR, Chang GY, Marco-Rius I, Milshteyn E, Wang ZJ, Ohliger MA, Gleason CE, Kurhanewicz J, Vigneron DB, Pearce D. Non-invasive detection of divergent metabolic signals in insulin deficiency vs. insulin resistance in vivo. Sci Rep. 2018 Feb 01; 8(1):2088. PMID: 29391429.
      View in: PubMed
    9. von Morze C, Ohliger MA, Marco-Rius I, Wilson DM, Flavell RR, Pearce D, Vigneron DB, Kurhanewicz J, Wang ZJ. Direct assessment of renal mitochondrial redox state using hyperpolarized 13 C-acetoacetate. Magn Reson Med. 2018 Apr; 79(4):1862-1869. PMID: 29314217.
      View in: PubMed
    10. Baghdanian AH, Baghdanian AA, Puppala S, Tana M, Ohliger MA. Imaging Manifestations of Peptic Ulcer Disease on Computed Tomography. Semin Ultrasound CT MR. 2018 Apr; 39(2):183-192. PMID: 29571554.
      View in: PubMed
    11. von Morze C, Tropp J, Chen AP, Marco-Rius I, Van Criekinge M, Skloss TW, Mammoli D, Kurhanewicz J, Vigneron DB, Ohliger MA, Merritt ME. Sensitivity enhancement for detection of hyperpolarized 13 C MRI probes with 1 H spin coupling introduced by enzymatic transformation in vivo. Magn Reson Med. 2018 Jul; 80(1):36-41. PMID: 29193287.
      View in: PubMed
    12. Tang A, Bashir MR, Corwin MT, Cruite I, Dietrich CF, Do RKG, Ehman EC, Fowler KJ, Hussain HK, Jha RC, Karam AR, Mamidipalli A, Marks RM, Mitchell DG, Morgan TA, Ohliger MA, Shah A, Vu KN, Sirlin CB. Evidence Supporting LI-RADS Major Features for CT- and MR Imaging-based Diagnosis of Hepatocellular Carcinoma: A Systematic Review. Radiology. 2018 Jan; 286(1):29-48. PMID: 29166245.
      View in: PubMed
    13. Neumann KD, Villanueva-Meyer JE, Mutch CA, Flavell RR, Blecha JE, Kwak T, Sriram R, VanBrocklin HF, Rosenberg OS, Ohliger MA, Wilson DM. Imaging Active Infection in vivo Using D-Amino Acid Derived PET Radiotracers. Sci Rep. 2017 Aug 11; 7(1):7903. PMID: 28801560.
      View in: PubMed
    14. Horowitz JM, Venkatesh SK, Ehman RL, Jhaveri K, Kamath P, Ohliger MA, Samir AE, Silva AC, Taouli B, Torbenson MS, Wells ML, Yeh B, Miller FH. Evaluation of hepatic fibrosis: a review from the society of abdominal radiology disease focus panel. Abdom Radiol (NY). 2017 Aug; 42(8):2037-2053. PMID: 28624924.
      View in: PubMed
    15. Leelakanok N, Phelps AS, Zapala MA, Kato K, Ohliger M, Li Y, Courtier J. Assessing 3D T2 FSE sequence for identification of the normal appendix: working toward a single-sequence MR appendicitis protocol. Emerg Radiol. 2017 Dec; 24(6):653-660. PMID: 28725923.
      View in: PubMed
    16. Ohliger MA, Hope TA, Chapman JS, Chen LM, Behr SC, Poder L. PET/MR Imaging in Gynecologic Oncology. Magn Reson Imaging Clin N Am. 2017 Aug; 25(3):667-684. PMID: 28668166.
      View in: PubMed
    17. Wilson DM, Di Gialleonardo V, Wang ZJ, Carroll V, Von Morze C, Taylor A, Sai V, VanCriekinge M, Bok R, Ohliger MA, Keshari KR. Hyperpolarized 13C Spectroscopic Evaluation of Oxidative Stress in a Rodent Model of Steatohepatitis. Sci Rep. 2017 Apr 20; 7:46014. PMID: 28425467.
      View in: PubMed
    18. Marco-Rius I, Gordon JW, Mattis AN, Bok R, Delos Santos R, Sukumar S, Larson PEZ, Vigneron DB, Ohliger MA. Diffusion-weighted imaging of hyperpolarized [13 C]urea in mouse liver. J Magn Reson Imaging. 2018 Jan; 47(1):141-151. PMID: 28419644.
      View in: PubMed
    19. Lambert JW, Sun Y, Gould RG, Ohliger MA, Li Z, Yeh BM. An Image-Domain Contrast Material Extraction Method for Dual-Energy Computed Tomography. Invest Radiol. 2017 04; 52(4):245-254. PMID: 27875338.
      View in: PubMed
    20. Dotson B, Lambert JW, Wang ZJ, Sun Y, Ohliger MA, Winklhofer S, Yeh BM. Benefit of iodine density images to reduce out-of-field image artifacts at rapid kVp switching dual-energy CT. Abdom Radiol (NY). 2017 Mar; 42(3):735-741. PMID: 27847997.
      View in: PubMed
    21. Marco-Rius I, von Morze C, Sriram R, Cao P, Chang GY, Milshteyn E, Bok RA, Ohliger MA, Pearce D, Kurhanewicz J, Larson PE, Vigneron DB, Merritt M. Monitoring acute metabolic changes in the liver and kidneys induced by fructose and glucose using hyperpolarized [2-13 C]dihydroxyacetone. Magn Reson Med. 2017 Jan; 77(1):65-73. PMID: 27859575.
      View in: PubMed
    22. Ehman EC, Umetsu SE, Ohliger MA, Fidelman N, Ferrell LD, Yeh BM, Yee J, Hope TA. Imaging prediction of residual hepatocellular carcinoma after locoregional therapy in patients undergoing liver transplantation or partial hepatectomy. Abdom Radiol (NY). 2016 Nov; 41(11):2161-2168. PMID: 27484789.
      View in: PubMed
    23. Shang H, Sukumar S, von Morze C, Bok RA, Marco-Rius I, Kerr A, Reed GD, Milshteyn E, Ohliger MA, Kurhanewicz J, Larson PEZ, Pauly JM, Vigneron DB. Spectrally selective three-dimensional dynamic balanced steady-state free precession for hyperpolarized C-13 metabolic imaging with spectrally selective radiofrequency pulses. Magn Reson Med. 2017 Sep; 78(3):963-975. PMID: 27770458.
      View in: PubMed
    24. Gordon JW, Milshteyn E, Marco-Rius I, Ohliger M, Vigneron DB, Larson PEZ. Mis-estimation and bias of hyperpolarized apparent diffusion coefficient measurements due to slice profile effects. Magn Reson Med. 2017 Sep; 78(3):1087-1092. PMID: 27735082.
      View in: PubMed
    25. Ehman EC, Phelps AS, Ohliger MA, Rhee SJ, MacKenzie JD, Courtier JL. Detection of bowel inflammation with fused DWI/T2 images versus contrast-enhanced images in pediatric MR enterography with histopathologic correlation. Clin Imaging. 2016 Nov - Dec; 40(6):1135-1139. PMID: 27497037.
      View in: PubMed
    26. Ohliger MA, von Morze C, Marco-Rius I, Gordon J, Larson PEZ, Bok R, Chen HY, Kurhanewicz J, Vigneron D. Combining hyperpolarized 13 C MRI with a liver-specific gadolinium contrast agent for selective assessment of hepatocyte metabolism. Magn Reson Med. 2017 Jun; 77(6):2356-2363. PMID: 27298073.
      View in: PubMed
    27. Hicks RM, Yee J, Ohliger MA, Weinstein S, Kao J, Ikram NS, Hope TA. Comparison of diffusion-weighted imaging and T2-weighted single shot fast spin-echo: Implications for LI-RADS characterization of hepatocellular carcinoma. Magn Reson Imaging. 2016 09; 34(7):915-21. PMID: 27108359.
      View in: PubMed
    28. Marco-Rius I, Cao P, von Morze C, Merritt M, Moreno KX, Chang GY, Ohliger MA, Pearce D, Kurhanewicz J, Larson PE, Vigneron DB. Multiband spectral-spatial RF excitation for hyperpolarized [2-13 C]dihydroxyacetone 13 C-MR metabolism studies. Magn Reson Med. 2017 Apr; 77(4):1419-1428. PMID: 27017966.
      View in: PubMed
    29. Shang H, Larson PEZ, Kerr A, Reed G, Sukumar S, Elkhaled A, Gordon JW, Ohliger MA, Pauly JM, Lustig M, Vigneron DB. Multiband RF pulses with improved performance via convex optimization. J Magn Reson. 2016 Jan; 262:81-90. PMID: 26754063.
      View in: PubMed
    30. Feng Y, Gordon JW, Shin PJ, von Morze C, Lustig M, Larson PEZ, Ohliger MA, Carvajal L, Tropp J, Pauly JM, Vigneron DB. Development and testing of hyperpolarized (13)C MR calibrationless parallel imaging. J Magn Reson. 2016 Jan; 262:1-7. PMID: 26679288; PMCID: PMC4864033 [Available on 01/01/17].
      View in: PubMed, PubMed Central
    31. Hope TA, Verdin EF, Bergsland EK, Ohliger MA, Corvera CU, Nakakura EK. Correcting for respiratory motion in liver PET/MRI: preliminary evaluation of the utility of bellows and navigated hepatobiliary phase imaging. EJNMMI Phys. 2015 Dec; 2(1):21. PMID: 26501822; PMCID: PMC4573645.
      View in: PubMed, PubMed Central
    32. Lee SA, Plett SK, Luetkemeyer AF, Borgo GM, Ohliger MA, Conrad MB, Cookson BT, Sengupta DJ, Koehler JE. Bartonella quintana Aortitis in a Man with AIDS, Diagnosed by Needle Biopsy and 16S rRNA Gene Amplification. J Clin Microbiol. 2015 Aug; 53(8):2773-6. PMID: 26063867; PMCID: PMC4508458.
      View in: PubMed, PubMed Central
    33. von Morze C, Bok RA, Ohliger MA, Zhu Z, Vigneron DB, Kurhanewicz J. Hyperpolarized [(13)C]ketobutyrate, a molecular analog of pyruvate with modified specificity for LDH isoforms. Magn Reson Med. 2016 May; 75(5):1894-900. PMID: 26059096; PMCID: PMC4868134 [Available on 05/01/17].
      View in: PubMed, PubMed Central
    34. Shin PJ, Larson PE, Uecker M, Reed GD, Kerr AB, Tropp J, Ohliger MA, Nelson SJ, Pauly JM, Lustig M, Vigneron DB. Chemical shift separation with controlled aliasing for hyperpolarized (13) C metabolic imaging. Magn Reson Med. 2015 Oct; 74(4):978-89. PMID: 25298086; PMCID: PMC4390401 [Available on 10/01/16].
      View in: PubMed, PubMed Central
    35. Hope TA, Ohliger MA, Qayyum A. MR imaging of diffuse liver disease: from technique to diagnosis. Radiol Clin North Am. 2014 Jul; 52(4):709-24. PMID: 24889168.
      View in: PubMed
    36. Shin PJ, Larson PE, Ohliger MA, Elad M, Pauly JM, Vigneron DB, Lustig M. Calibrationless parallel imaging reconstruction based on structured low-rank matrix completion. Magn Reson Med. 2014 Oct; 72(4):959-70. PMID: 24248734; PMCID: PMC4025999.
      View in: PubMed, PubMed Central
    37. Courtier J, Ohliger M, Rhee SJ, Terreblanche O, Heyman MB, MacKenzie JD. Shooting a moving target: use of real-time cine magnetic resonance imaging in assessment of the small bowel. J Pediatr Gastroenterol Nutr. 2013 Oct; 57(4):426-31. PMID: 24080754.
      View in: PubMed
    38. Ohliger MA, Larson PE, Bok RA, Shin P, Hu S, Tropp J, Robb F, Carvajal L, Nelson SJ, Kurhanewicz J, Vigneron DB. Combined parallel and partial fourier MR reconstruction for accelerated 8-channel hyperpolarized carbon-13 in vivo magnetic resonance Spectroscopic imaging (MRSI). J Magn Reson Imaging. 2013 Sep; 38(3):701-13. PMID: 23293097; PMCID: PMC3759833.
      View in: PubMed, PubMed Central
    39. Lattanzi R, Grant AK, Polimeni JR, Ohliger MA, Wiggins GC, Wald LL, Sodickson DK. Performance evaluation of a 32-element head array with respect to the ultimate intrinsic SNR. NMR Biomed. 2010 Feb; 23(2):142-51. PMID: 19904727; PMCID: PMC2830315.
      View in: PubMed, PubMed Central
    40. Ohliger MA, Sodickson DK. An introduction to coil array design for parallel MRI. NMR Biomed. 2006 May; 19(3):300-15. PMID: 16705631.
      View in: PubMed
    41. Ohliger MA, Greenman RL, Giaquinto R, McKenzie CA, Wiggins G, Sodickson DK. Concentric coil arrays for parallel MRI. Magn Reson Med. 2005 Nov; 54(5):1248-60. PMID: 16206147.
      View in: PubMed
    42. Willig-Onwuachi JD, Yeh EN, Grant AK, Ohliger MA, McKenzie CA, Sodickson DK. Phase-constrained parallel MR image reconstruction. J Magn Reson. 2005 Oct; 176(2):187-98. PMID: 16027017.
      View in: PubMed
    43. Yeh EN, Stuber M, McKenzie CA, Botnar RM, Leiner T, Ohliger MA, Grant AK, Willig-Onwuachi JD, Sodickson DK. Inherently self-calibrating non-Cartesian parallel imaging. Magn Reson Med. 2005 Jul; 54(1):1-8. PMID: 15968671.
      View in: PubMed
    44. Yeh EN, McKenzie CA, Ohliger MA, Sodickson DK. Parallel magnetic resonance imaging with adaptive radius in k-space (PARS): constrained image reconstruction using k-space locality in radiofrequency coil encoded data. Magn Reson Med. 2005 Jun; 53(6):1383-92. PMID: 15906283.
      View in: PubMed
    45. Sodickson DK, Hardy CJ, Zhu Y, Giaquinto RO, Gross P, Kenwood G, Niendorf T, Lejay H, McKenzie CA, Ohliger MA, Grant AK, Rofsky NM. Rapid volumetric MRI using parallel imaging with order-of-magnitude accelerations and a 32-element RF coil array: feasibility and implications. Acad Radiol. 2005 May; 12(5):626-35. PMID: 15866137; PMCID: PMC2819014.
      View in: PubMed, PubMed Central
    46. Zhu Y, Hardy CJ, Sodickson DK, Giaquinto RO, Dumoulin CL, Kenwood G, Niendorf T, Lejay H, McKenzie CA, Ohliger MA, Rofsky NM. Highly parallel volumetric imaging with a 32-element RF coil array. Magn Reson Med. 2004 Oct; 52(4):869-77. PMID: 15389961; PMCID: PMC2819016.
      View in: PubMed, PubMed Central
    47. Ohliger MA, Ledden P, McKenzie CA, Sodickson DK. Effects of inductive coupling on parallel MR image reconstructions. Magn Reson Med. 2004 Sep; 52(3):628-39. PMID: 15334584.
      View in: PubMed
    48. Ohliger MA, Grant AK, Sodickson DK. Ultimate intrinsic signal-to-noise ratio for parallel MRI: electromagnetic field considerations. Magn Reson Med. 2003 Nov; 50(5):1018-30. PMID: 14587013.
      View in: PubMed
    49. McKenzie CA, Yeh EN, Ohliger MA, Price MD, Sodickson DK. Self-calibrating parallel imaging with automatic coil sensitivity extraction. Magn Reson Med. 2002 Mar; 47(3):529-38. PMID: 11870840.
      View in: PubMed
    50. Sodickson DK, McKenzie CA, Ohliger MA, Yeh EN, Price MD. Recent advances in image reconstruction, coil sensitivity calibration, and coil array design for SMASH and generalized parallel MRI. MAGMA. 2002 Jan; 13(3):158-63. PMID: 11755091.
      View in: PubMed
    51. McKenzie CA, Ohliger MA, Yeh EN, Price MD, Sodickson DK. Coil-by-coil image reconstruction with SMASH. Magn Reson Med. 2001 Sep; 46(3):619-23. PMID: 11550258.
      View in: PubMed
    52. Foster MH, Kieber-Emmons T, Ohliger M, Madaio MP. Molecular and structural analysis of nuclear localizing anti-DNA lupus antibodies. Immunol Res. 1994; 13(2-3):186-206. PMID: 7775809.
      View in: PubMed
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