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Matthew Kutys, PhD

Title(s)Assistant Professor, Cell and Tissue Biology
SchoolSchool of Dentistry
Phone415-502-2247
EmailMatthew.Kutys@ucsf.edu
ORCID ORCID Icon0000-0002-0752-649X Additional info
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    Collapse Biography 
    Collapse Education and Training
    Pennsylvania State UniversityB.S.2009Bioengineering
    University of North Carolina Chapel HillPh.D.12/2014Cell and Developmental Biology
    National Institutes of HealthPh.D12/2014Cell and Developmental Biology
    Boston UniversityPostdoc12/2019Bioengineering, Cell Biology
    Collapse Awards and Honors
    Pennsylvania State University2009Schreyer Honors Scholar
    NIH2010NIH-GPP Graduate Fellowship
    NIH2013Fellow's Award for Research Excellence (FARE)
    Boston University2015NIBIB T32 NRSA Postdoctoral Fellowship
    The Hartwell Foundation2016The Hartwell Foundation Postdoctoral Fellowship
    Boston University2018Wallace H. Coulter Translational Research Partnership Award
    NIH2018NCI K99/R00 Pathway to Independence Award National Cancer Institute

    Collapse Overview 
    Collapse Overview
    The Kutys Lab spans disciplinary boundaries between cell biology and engineering to investigate tissue morphogenic processes associated with human development, regeneration and disease. Ultimately, we are interested in uncovering fundamental molecular and mechanical mechanisms that conspire across time and length scales to organize and shape human tissues. To do so, we develop microfluidic, biomimetic human tissue models that recapitulate 3D in vivo architectures, microenvironments, cellular heterogeneity, and morphogenic behaviors that can be examined mechanistically by biochemical and cell biological approaches. Combined with advanced microscopy, cellular and molecular engineering, and 'omic' technologies, our multidisciplinary approach allows us to model, control, and dissect complex multicellular behaviors at a level previously only accessible in vivo.

    At the molecular level, we are experts in elucidating new mechanisms underlying adhesion biology, the interactions of cells with their neighbors and their microenvironment. We study how core adhesion molecules like cadherins and integrins integrate and orchestrate chemical and mechano-signaling to specify multicellular behavior, proper organization and differentiation of complex tissues, as well as facilitate the progression of disease.

    At the cellular level, we develop and apply quantitative imaging and molecular tools (optogenetics, synthetic biology, microenvironment biomaterials/patterning) that allow us to measure, direct, and perturb cellular behaviors to understand how collective decisions initiate and propagate within tissues.

    At the tissue level, we engineer organotypic 3D microfluidic models of human tissues with defined architectures and microenvironments in vitro that permit the simulation, molecular dissection, and quantitative analysis of in vivo-like morphogenic processes. We are working to combine these platforms with organoid systems, unbiased proteomics, and single-cell analyses to build spatio-temporal road maps of human development and disease.

    Collapse Research 
    Collapse Research Activities and Funding
    Non-canonical Notch1 regulation of proliferation and adherens junctions in breast cancer
    NIH/NCI R00CA226366Feb 1, 2020 - Jan 31, 2023
    Role: Principal Investigator
    Non-canonical Notch1 regulation of proliferation and adherens junctions in breast cancer
    NIH/NCI K99CA226366Sep 1, 2018 - Aug 31, 2020
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Polacheck WJ, Kutys ML, Tefft JB, Chen CS. Microfabricated blood vessels for modeling the vascular transport barrier. Nat Protoc. 2019 05; 14(5):1425-1454. PMID: 30953042.
      View in: PubMed
    2. Wang WY, Pearson AT, Kutys ML, Choi CK, Wozniak MA, Baker BM, Chen CS. Extracellular matrix alignment dictates the organization of focal adhesions and directs uniaxial cell migration. APL Bioeng. 2018 Dec; 2(4):046107. PMID: 31069329.
      View in: PubMed
    3. Chopra A, Kutys ML, Zhang K, Polacheck WJ, Sheng CC, Luu RJ, Eyckmans J, Hinson JT, Seidman JG, Seidman CE, Chen CS. Force Generation via ß-Cardiac Myosin, Titin, and a-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions. Dev Cell. 2018 01 08; 44(1):87-96.e5. PMID: 29316444.
      View in: PubMed
    4. Polacheck WJ, Kutys ML, Yang J, Eyckmans J, Wu Y, Vasavada H, Hirschi KK, Chen CS. A non-canonical Notch complex regulates adherens junctions and vascular barrier function. Nature. 2017 12 14; 552(7684):258-262. PMID: 29160307.
      View in: PubMed
    5. Kutys ML, Chen CS. Forces and mechanotransduction in 3D vascular biology. Curr Opin Cell Biol. 2016 10; 42:73-79. PMID: 27209346.
      View in: PubMed
    6. Kutys ML, Yamada KM. Rho GEFs and GAPs: emerging integrators of extracellular matrix signaling. Small GTPases. 2015; 6(1):16-9. PMID: 25862162.
      View in: PubMed
    7. Kutys ML, Yamada KM. An extracellular-matrix-specific GEF-GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration. Nat Cell Biol. 2014 Sep; 16(9):909-17. PMID: 25150978.
      View in: PubMed
    8. Doyle AD, Petrie RJ, Kutys ML, Yamada KM. Dimensions in cell migration. Curr Opin Cell Biol. 2013 Oct; 25(5):642-9. PMID: 23850350.
      View in: PubMed
    9. Kutys ML, Doyle AD, Yamada KM. Regulation of cell adhesion and migration by cell-derived matrices. Exp Cell Res. 2013 Oct 01; 319(16):2434-9. PMID: 23751565.
      View in: PubMed
    10. Li X, Zhou Q, Sunkara M, Kutys ML, Wu Z, Rychahou P, Morris AJ, Zhu H, Evers BM, Huang C. Ubiquitylation of phosphatidylinositol 4-phosphate 5-kinase type I ? by HECTD1 regulates focal adhesion dynamics and cell migration. J Cell Sci. 2013 Jun 15; 126(Pt 12):2617-28. PMID: 23572508.
      View in: PubMed
    11. Doyle AD, Kutys ML, Conti MA, Matsumoto K, Adelstein RS, Yamada KM. Micro-environmental control of cell migration--myosin IIA is required for efficient migration in fibrillar environments through control of cell adhesion dynamics. J Cell Sci. 2012 May 01; 125(Pt 9):2244-56. PMID: 22328520.
      View in: PubMed
    12. Kutys ML, Fricks J, Hancock WO. Monte Carlo analysis of neck linker extension in kinesin molecular motors. PLoS Comput Biol. 2010 Nov 04; 6(11):e1000980. PMID: 21079666.
      View in: PubMed