Matthew Kutys, PhD

Title(s)Assistant Professor, Cell and Tissue Biology
SchoolSchool of Dentistry
Address513 Parnassus Avenue, HSW, #613
San Francisco CA 94143
Phone415-502-2247
Emailmatthew.kutys@ucsf.edu
ORCID ORCID Icon0000-0002-0752-649X Additional info
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    Collapse Biography 
    Collapse Education and Training
    Pennsylvania State UniversityB.S.2009Bioengineering
    University of North Carolina Chapel HillPh.D.12/2014Cell and Developmental Biology
    National Institutes of HealthPh.D12/2014Cell and Developmental Biology
    Boston UniversityPostdoc12/2019Bioengineering, Cell Biology
    University of California, San Francisco, CA2021Diversity, Equity, and Inclusion Champion Training
    Collapse Awards and Honors
    NIH2010NIH-GPP Graduate Fellowship
    NIH2013Fellow's Award for Research Excellence (FARE)
    The Hartwell Foundation2016The Hartwell Foundation Postdoctoral Fellowship
    Boston University2018Wallace H. Coulter Translational Research Partnership Award
    NIH2018NCI K99/R00 Pathway to Independence Award National Cancer Institute
    UCSF2020Program for Breakthrough Biomedical Research New Frontiers Research Award
    UCSF2022Program for Breakthrough Biomedical Research New Frontiers Research Award

    Collapse Overview 
    Collapse Overview
    The Kutys Lab spans disciplinary boundaries between cell biology and engineering to investigate tissue morphogenic processes associated with human development, regeneration and disease. Ultimately, we are interested in uncovering fundamental molecular and mechanical mechanisms that conspire across time and length scales to organize and shape human tissues. To do so, we develop microfluidic, biomimetic human tissue models that recapitulate 3D in vivo architectures, microenvironments, cellular heterogeneity, and morphogenic behaviors that can be examined mechanistically by biochemical and cell biological approaches. Combined with advanced microscopy, cellular and molecular engineering, and 'omic' technologies, our multidisciplinary approach allows us to model, control, and dissect complex multicellular behaviors at a level previously only accessible in vivo. ​Our lab broadly investigates how biochemical and mechanical signals at cell-cell and cell-extracellular matrix adhesions are coordinated across biological scales (molecules to cells to tissues) to maintain normal tissue structure or drive pathology.

    Collapse Research 
    Collapse Research Activities and Funding
    3D biomimetic human tuberculosis granulomas to identify novel host-pathogen interactions
    NIH R21AI176234Dec 1, 2023 - Oct 31, 2025
    Role: Principal Investigator
    Decoding cortical Notch signaling and morphogenic instruction at cell-cell interfaces
    NIH R35GM150987Jul 20, 2023 - Jun 30, 2028
    Role: Principal Investigator
    Notch1 and APP signaling in cerebral microvascular dysfunction
    NIH R21AG072232Apr 15, 2021 - Mar 31, 2023
    Role: Principal Investigator
    Non-canonical Notch1 regulation of proliferation and adherens junctions in breast cancer
    NIH R00CA226366Feb 1, 2020 - Jan 31, 2023
    Role: Principal Investigator
    Non-canonical Notch1 regulation of proliferation and adherens junctions in breast cancer
    NIH K99CA226366Sep 1, 2018 - Aug 31, 2020
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Proinflammatory immune cells disrupt angiogenesis and promote germinal matrix hemorrhage in prenatal human brain. Nat Neurosci. 2024 Sep 30. Chen J, Crouch EE, Zawadzki ME, Jacobs KA, Mayo LN, Choi JJ, Lin PY, Shaikh S, Tsui J, Gonzalez-Granero S, Waller S, Kelekar A, Kang G, Valenzuela EJ, Birrueta JO, Diafos LN, Wedderburn-Pugh K, Di Marco B, Xia W, Han CZ, Coufal NG, Glass CK, Fancy SPJ, Alfonso J, Kriegstein AR, Oldham MC, Garcia-Verdugo JM, Kutys ML, Lehtinen MK, Combes AJ, Huang EJ. PMID: 39349662.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Arp2/3 complex activity enables nuclear YAP for naïve pluripotency of human embryonic stem cells. Elife. 2024 Sep 25; 13. Meyer NP, Singh T, Kutys ML, Nystul TG, Barber DL. PMID: 39319536.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    3. Quantitative Comparison of Monomeric StayGold Variants Using Protein Nanocages in Living Cells. bioRxiv. 2024 Sep 17. Viola G, Jacobs KA, Lemière J, Kutys ML, Wittmann T. PMID: 39345619; PMCID: PMC11429717.
      View in: PubMed   Mentions:
    4. Doublecortin reinforces microtubules to promote growth cone advance in soft environments. bioRxiv. 2024 Feb 29. Dema A, Charafeddine RA, van Haren J, Rahgozar S, Viola G, Jacobs KA, Kutys ML, Wittmann T. PMID: 38464100; PMCID: PMC10925279.
      View in: PubMed   Mentions: 1  
    5. Notch1 cortical signaling regulates epithelial architecture and cell-cell adhesion. J Cell Biol. 2023 12 04; 222(12). White MJ, Jacobs KA, Singh T, Mayo LN, Lin A, Chen CS, Jun YW, Kutys ML. PMID: 37796194; PMCID: PMC10555887.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    6. A 3D biomimetic model of lymphatics reveals cell-cell junction tightening and lymphedema via a cytokine-induced ROCK2/JAM-A complex. Proc Natl Acad Sci U S A. 2023 10 10; 120(41):e2308941120. Lee E, Chan SL, Lee Y, Polacheck WJ, Kwak S, Wen A, Nguyen DT, Kutys ML, Alimperti S, Kolarzyk AM, Kwak TJ, Eyckmans J, Bielenberg DR, Chen H, Chen CS. PMID: 37782785; PMCID: PMC10576061.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    7. 'Chip'-ing away at morphogenesis - application of organ-on-chip technologies to study tissue morphogenesis. J Cell Sci. 2023 10 01; 136(19). White MJ, Singh T, Wang E, Smith Q, Kutys ML. PMID: 37795818; PMCID: PMC10565497.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. A convolutional neural network STIFMap reveals associations between stromal stiffness and EMT in breast cancer. Nat Commun. 2023 06 15; 14(1):3561. Stashko C, Hayward MK, Northey JJ, Pearson N, Ironside AJ, Lakins JN, Oria R, Goyette MA, Mayo L, Russnes HG, Hwang ES, Kutys ML, Polyak K, Weaver VM. PMID: 37322009; PMCID: PMC10272194.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    9. Modeling collective cell behavior in cancer: Perspectives from an interdisciplinary conversation. Cell Syst. 2023 04 19; 14(4):252-257. Adler FR, Anderson ARA, Bhushan A, Bogdan P, Bravo-Cordero JJ, Brock A, Chen Y, Cukierman E, DelGiorno KE, Denis GV, Ferrall-Fairbanks MC, Gartner ZJ, Germain RN, Gordon DM, Hunter G, Jolly MK, Karacosta LG, Mythreye K, Katira P, Kulkarni RP, Kutys ML, Lander AD, Laughney AM, Levine H, Lou E, Lowenstein PR, Masters KS, Pe'er D, Peyton SR, Platt MO, Purvis JE, Quon G, Richer JK, Riddle NC, Rodriguez A, Snyder JC, Lee Szeto G, Tomlin CJ, Yanai I, Zervantonakis IK, Dueck H. PMID: 37080161; PMCID: PMC10760508.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    10. Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation. Sci Adv. 2023 02 15; 9(7):eade8939. Aw WY, Cho C, Wang H, Cooper AH, Doherty EL, Rocco D, Huang SA, Kubik S, Whitworth CP, Armstrong R, Hickey AJ, Griffith B, Kutys ML, Blatt J, Polacheck WJ. PMID: 36791204; PMCID: PMC9931220.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    11. Notch1 cortical signaling regulates epithelial architecture and cell-cell adhesion. bioRxiv. 2023 Jan 23. White MJ, Jacobs KA, Singh T, Kutys ML. PMID: 36747830; PMCID: PMC9900753.
      View in: PubMed   Mentions:
    12. Adherens junctions organize size-selective proteolytic hotspots critical for Notch signalling. Nat Cell Biol. 2022 12; 24(12):1739-1753. Kwak M, Southard KM, Kim WR, Lin A, Kim NH, Gopalappa R, Lee HJ, An M, Choi SH, Jung Y, Noh K, Farlow J, Georgakopoulos A, Robakis NK, Kang MK, Kutys ML, Seo D, Kim HH, Kim YH, Cheon J, Gartner ZJ, Jun YW. PMID: 36456828; PMCID: PMC10665132.
      View in: PubMed   Mentions: 6     Fields:    
    13. Conversation before crossing: dissecting metastatic tumor-vascular interactions in microphysiological systems. Am J Physiol Cell Physiol. 2022 11 01; 323(5):C1333-C1344. Mayo LN, Kutys ML. PMID: 36121131; PMCID: PMC9602802.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    14. 3D mesenchymal cell migration is driven by anterior cellular contraction that generates an extracellular matrix prestrain. Dev Cell. 2021 03 22; 56(6):826-841.e4. Doyle AD, Sykora DJ, Pacheco GG, Kutys ML, Yamada KM. PMID: 33705692; PMCID: PMC8082573.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    15. Uncovering mutation-specific morphogenic phenotypes and paracrine-mediated vessel dysfunction in a biomimetic vascularized mammary duct platform. Nat Commun. 2020 07 06; 11(1):3377. Kutys ML, Polacheck WJ, Welch MK, Gagnon KA, Koorman T, Kim S, Li L, McClatchey AI, Chen CS. PMID: 32632100; PMCID: PMC7338408.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    16. Microfabricated blood vessels for modeling the vascular transport barrier. Nat Protoc. 2019 05; 14(5):1425-1454. Polacheck WJ, Kutys ML, Tefft JB, Chen CS. PMID: 30953042; PMCID: PMC7046311.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansCells
    17. Extracellular matrix alignment dictates the organization of focal adhesions and directs uniaxial cell migration. APL Bioeng. 2018 Dec; 2(4):046107. Wang WY, Pearson AT, Kutys ML, Choi CK, Wozniak MA, Baker BM, Chen CS. PMID: 31069329; PMCID: PMC6481732.
      View in: PubMed   Mentions: 46  
    18. Force Generation via β-Cardiac Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions. Dev Cell. 2018 01 08; 44(1):87-96.e5. Chopra A, Kutys ML, Zhang K, Polacheck WJ, Sheng CC, Luu RJ, Eyckmans J, Hinson JT, Seidman JG, Seidman CE, Chen CS. PMID: 29316444; PMCID: PMC6421364.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansCells
    19. A non-canonical Notch complex regulates adherens junctions and vascular barrier function. Nature. 2017 12 14; 552(7684):258-262. Polacheck WJ, Kutys ML, Yang J, Eyckmans J, Wu Y, Vasavada H, Hirschi KK, Chen CS. PMID: 29160307; PMCID: PMC5730479.
      View in: PubMed   Mentions: 175     Fields:    Translation:HumansAnimalsCells
    20. Forces and mechanotransduction in 3D vascular biology. Curr Opin Cell Biol. 2016 10; 42:73-79. Kutys ML, Chen CS. PMID: 27209346; PMCID: PMC5064809.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    21. Rho GEFs and GAPs: emerging integrators of extracellular matrix signaling. Small GTPases. 2015; 6(1):16-9. Kutys ML, Yamada KM. PMID: 25862162; PMCID: PMC4601481.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    22. An extracellular-matrix-specific GEF-GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration. Nat Cell Biol. 2014 Sep; 16(9):909-17. Kutys ML, Yamada KM. PMID: 25150978; PMCID: PMC4150836.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    23. Dimensions in cell migration. Curr Opin Cell Biol. 2013 Oct; 25(5):642-9. Doyle AD, Petrie RJ, Kutys ML, Yamada KM. PMID: 23850350; PMCID: PMC3758466.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    24. Regulation of cell adhesion and migration by cell-derived matrices. Exp Cell Res. 2013 Oct 01; 319(16):2434-9. Kutys ML, Doyle AD, Yamada KM. PMID: 23751565; PMCID: PMC3780580.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    25. Ubiquitylation of phosphatidylinositol 4-phosphate 5-kinase type I γ by HECTD1 regulates focal adhesion dynamics and cell migration. J Cell Sci. 2013 Jun 15; 126(Pt 12):2617-28. Li X, Zhou Q, Sunkara M, Kutys ML, Wu Z, Rychahou P, Morris AJ, Zhu H, Evers BM, Huang C. PMID: 23572508; PMCID: PMC3687698.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    26. Micro-environmental control of cell migration--myosin IIA is required for efficient migration in fibrillar environments through control of cell adhesion dynamics. J Cell Sci. 2012 May 01; 125(Pt 9):2244-56. Doyle AD, Kutys ML, Conti MA, Matsumoto K, Adelstein RS, Yamada KM. PMID: 22328520; PMCID: PMC3367941.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    27. Monte Carlo analysis of neck linker extension in kinesin molecular motors. PLoS Comput Biol. 2010 Nov 04; 6(11):e1000980. Kutys ML, Fricks J, Hancock WO. PMID: 21079666; PMCID: PMC2973807.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
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