Matthew Kutys, PhD
Biography Pennsylvania State University | B.S. | 2009 | Bioengineering | University of North Carolina Chapel Hill | Ph.D. | 12/2014 | Cell and Developmental Biology | National Institutes of Health | Ph.D | 12/2014 | Cell and Developmental Biology | Boston University | Postdoc | 12/2019 | Bioengineering, Cell Biology |
Pennsylvania State University | 2009 | | Schreyer Honors Scholar | NIH | 2010 | | NIH-GPP Graduate Fellowship | NIH | 2013 | | Fellow's Award for Research Excellence (FARE) | Boston University | 2015 | | NIBIB T32 NRSA Postdoctoral Fellowship | The Hartwell Foundation | 2016 | | The Hartwell Foundation Postdoctoral Fellowship | Boston University | 2018 | | Wallace H. Coulter Translational Research Partnership Award | NIH | 2018 | | NCI K99/R00 Pathway to Independence Award National Cancer Institute |
Overview The Kutys Lab spans disciplinary boundaries between cell biology and engineering to investigate tissue morphogenic processes associated with human development, regeneration and disease. Ultimately, we are interested in uncovering fundamental molecular and mechanical mechanisms that conspire across time and length scales to organize and shape human tissues. To do so, we develop microfluidic, biomimetic human tissue models that recapitulate 3D in vivo architectures, microenvironments, cellular heterogeneity, and morphogenic behaviors that can be examined mechanistically by biochemical and cell biological approaches. Combined with advanced microscopy, cellular and molecular engineering, and 'omic' technologies, our multidisciplinary approach allows us to model, control, and dissect complex multicellular behaviors at a level previously only accessible in vivo.
At the molecular level, we are experts in elucidating new mechanisms underlying adhesion biology, the interactions of cells with their neighbors and their microenvironment. We study how core adhesion molecules like cadherins and integrins integrate and orchestrate chemical and mechano-signaling to specify multicellular behavior, proper organization and differentiation of complex tissues, as well as facilitate the progression of disease.
At the cellular level, we develop and apply quantitative imaging and molecular tools (optogenetics, synthetic biology, microenvironment biomaterials/patterning) that allow us to measure, direct, and perturb cellular behaviors to understand how collective decisions initiate and propagate within tissues.
At the tissue level, we engineer organotypic 3D microfluidic models of human tissues with defined architectures and microenvironments in vitro that permit the simulation, molecular dissection, and quantitative analysis of in vivo-like morphogenic processes. We are working to combine these platforms with organoid systems, unbiased proteomics, and single-cell analyses to build spatio-temporal road maps of human development and disease.
Research ORNG Applications Bibliographic
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Uncovering mutation-specific morphogenic phenotypes and paracrine-mediated vessel dysfunction in a biomimetic vascularized mammary duct platform. Nat Commun. 2020 07 06; 11(1):3377.
Kutys ML, Polacheck WJ, Welch MK, Gagnon KA, Koorman T, Kim S, Li L, McClatchey AI, Chen CS. PMID: 32632100.
View in: PubMed Mentions: 1 Fields: Translation: HumansCells
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Microfabricated blood vessels for modeling the vascular transport barrier. Nat Protoc. 2019 05; 14(5):1425-1454.
Polacheck WJ, Kutys ML, Tefft JB, Chen CS. PMID: 30953042.
View in: PubMed Mentions: 9 Fields: Translation: HumansCells
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Extracellular matrix alignment dictates the organization of focal adhesions and directs uniaxial cell migration. APL Bioeng. 2018 Dec; 2(4):046107.
Wang WY, Pearson AT, Kutys ML, Choi CK, Wozniak MA, Baker BM, Chen CS. PMID: 31069329.
View in: PubMed Mentions:
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Force Generation via ß-Cardiac Myosin, Titin, and a-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions. Dev Cell. 2018 01 08; 44(1):87-96.e5.
Chopra A, Kutys ML, Zhang K, Polacheck WJ, Sheng CC, Luu RJ, Eyckmans J, Hinson JT, Seidman JG, Seidman CE, Chen CS. PMID: 29316444.
View in: PubMed Mentions: 22 Fields: Translation: HumansCells
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A non-canonical Notch complex regulates adherens junctions and vascular barrier function. Nature. 2017 12 14; 552(7684):258-262.
Polacheck WJ, Kutys ML, Yang J, Eyckmans J, Wu Y, Vasavada H, Hirschi KK, Chen CS. PMID: 29160307.
View in: PubMed Mentions: 38 Fields: Translation: HumansAnimalsCells
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Forces and mechanotransduction in 3D vascular biology. Curr Opin Cell Biol. 2016 10; 42:73-79.
Kutys ML, Chen CS. PMID: 27209346.
View in: PubMed Mentions: 11 Fields: Translation: HumansAnimalsCells
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Rho GEFs and GAPs: emerging integrators of extracellular matrix signaling. Small GTPases. 2015; 6(1):16-9.
Kutys ML, Yamada KM. PMID: 25862162.
View in: PubMed Mentions: 3 Fields: Translation: HumansCells
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An extracellular-matrix-specific GEF-GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration. Nat Cell Biol. 2014 Sep; 16(9):909-17.
Kutys ML, Yamada KM. PMID: 25150978.
View in: PubMed Mentions: 35 Fields: Translation: HumansCells
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Dimensions in cell migration. Curr Opin Cell Biol. 2013 Oct; 25(5):642-9.
Doyle AD, Petrie RJ, Kutys ML, Yamada KM. PMID: 23850350.
View in: PubMed Mentions: 64 Fields: Translation: HumansAnimalsCells
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Regulation of cell adhesion and migration by cell-derived matrices. Exp Cell Res. 2013 Oct 01; 319(16):2434-9.
Kutys ML, Doyle AD, Yamada KM. PMID: 23751565.
View in: PubMed Mentions: 21 Fields: Translation: HumansAnimalsCells
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Ubiquitylation of phosphatidylinositol 4-phosphate 5-kinase type I ? by HECTD1 regulates focal adhesion dynamics and cell migration. J Cell Sci. 2013 Jun 15; 126(Pt 12):2617-28.
Li X, Zhou Q, Sunkara M, Kutys ML, Wu Z, Rychahou P, Morris AJ, Zhu H, Evers BM, Huang C. PMID: 23572508.
View in: PubMed Mentions: 28 Fields: Translation: HumansAnimalsCells
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Micro-environmental control of cell migration--myosin IIA is required for efficient migration in fibrillar environments through control of cell adhesion dynamics. J Cell Sci. 2012 May 01; 125(Pt 9):2244-56.
Doyle AD, Kutys ML, Conti MA, Matsumoto K, Adelstein RS, Yamada KM. PMID: 22328520.
View in: PubMed Mentions: 45 Fields: Translation: AnimalsCells
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Monte Carlo analysis of neck linker extension in kinesin molecular motors. PLoS Comput Biol. 2010 Nov 04; 6(11):e1000980.
Kutys ML, Fricks J, Hancock WO. PMID: 21079666.
View in: PubMed Mentions: 14 Fields: Translation: Cells
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Year | Publications |
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2010 | 1 | 2012 | 1 | 2013 | 3 | 2014 | 1 | 2015 | 1 | 2016 | 1 | 2017 | 1 | 2018 | 2 | 2019 | 1 | 2020 | 1 |
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