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The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity. J Cell Biol. 2022 04 04; 221(4).
Stormo AED, Shavarebi F, FitzGibbon M, Earley EM, Ahrendt H, Lum LS, Verschueren E, Swaney DL, Skibinski G, Ravisankar A, van Haren J, Davis EJ, Johnson JR, Von Dollen J, Balen C, Porath J, Crosio C, Mirescu C, Iaccarino C, Dauer WT, Nichols RJ, Wittmann T, Cox TC, Finkbeiner S, Krogan NJ, Oakes SA, Hiniker A. PMID: 35266954; PMCID: PMC8919618.
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Translation:
HumansCells
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Optogenetic EB1 inactivation shortens metaphase spindles by disrupting cortical force-producing interactions with astral microtubules. Curr Biol. 2022 03 14; 32(5):1197-1205.e4.
Dema A, van Haren J, Wittmann T. PMID: 35090591; PMCID: PMC8930524.
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Translation:
AnimalsCells
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Controlling Cell Shape and Microtubule Organization by Extracellular Matrix Micropatterning. Methods Mol Biol. 2022; 2430:467-481.
Dema A, Rahgozar S, Siquier L, van Haren J, Wittmann T. PMID: 35476350.
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PubMed Mentions: Fields:
Translation:
Cells
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pHLARE: a new biosensor reveals decreased lysosome pH in cancer cells. Mol Biol Cell. 2021 01 15; 32(2):131-142.
Webb BA, Aloisio FM, Charafeddine RA, Cook J, Wittmann T, Barber DL. PMID: 33237838; PMCID: PMC8120692.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency. Nature. 2020 12; 588(7838):459-465.
Zhang J, Velmeshev D, Hashimoto K, Huang YH, Hofmann JW, Shi X, Chen J, Leidal AM, Dishart JG, Cahill MK, Kelley KW, Liddelow SA, Seeley WW, Miller BL, Walther TC, Farese RV, Taylor JP, Ullian EM, Huang B, Debnath J, Wittmann T, Kriegstein AR, Huang EJ. PMID: 32866962; PMCID: PMC7746606.
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PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
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Lights, cytoskeleton, action: Optogenetic control of cell dynamics. Curr Opin Cell Biol. 2020 10; 66:1-10.
Wittmann T, Dema A, van Haren J. PMID: 32371345; PMCID: PMC7577957.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Filament assembly by the liver phosphofructokinase-1, the “gatekeeper” of glycolysis. The FASEB Journal. 2020 Apr 1; 34(S1):1-1.
Webb WB, Dosey DA, Wittmann WT, Kollmann KJ, Barber BD. .
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Optogenetic Control of Microtubule Dynamics. Methods Mol Biol. 2020; 2101:211-234.
van Haren J, Adachi LS, Wittmann T. PMID: 31879907; PMCID: PMC7278073.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Tau repeat regions contain conserved histidine residues that modulate microtubule-binding in response to changes in pH. J Biol Chem. 2019 05 31; 294(22):8779-8790.
Charafeddine RA, Cortopassi WA, Lak P, Tan R, McKenney RJ, Jacobson MP, Barber DL, Wittmann T. PMID: 30992364; PMCID: PMC6552421.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Microtubule Plus End Dynamics - Do We Know How Microtubules Grow?: Cells boost microtubule growth by promoting distinct structural transitions at growing microtubule ends. Bioessays. 2019 03; 41(3):e1800194.
van Haren J, Wittmann T. PMID: 30730055; PMCID: PMC7021488.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Conserved tau microtubule-binding repeat histidines confer pH-dependent tau-microtubule association. bioRxiv. 2018 Dec 4; 486688.
Charafeddine CR, Cortopassi CW, Lak LP, Jacobson JM, Barber BD, Wittmann WT. .
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Optical Control of EB1 Reveals Local Functions of the Microtubule +TIP Complex During Cell Migration and Division. Biophysical Journal. 2018 Feb 1; 114(3):382a.
van Haren vJ, Charafeddine CR, Ettinger EA, Wang WH, Hahn HK, Wittmann WT. .
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The Glycolytic Enzyme Phosphofructokinase-1 Assembles into Filaments. Biophysical Journal. 2018 Feb 1; 114(3):228a.
Webb WB, Dosey DA, Wittmann WT, Kollman KJ, Barber BD. .
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Local control of intracellular microtubule dynamics by EB1 photodissociation. Nat Cell Biol. 2018 03; 20(3):252-261.
van Haren J, Charafeddine RA, Ettinger A, Wang H, Hahn KM, Wittmann T. PMID: 29379139; PMCID: PMC5826794.
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PubMed Mentions:
28 Fields:
Translation:
HumansCells
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The glycolytic enzyme phosphofructokinase-1 assembles into filaments. J Cell Biol. 2017 08 07; 216(8):2305-2313.
Webb BA, Dosey AM, Wittmann T, Kollman JM, Barber DL. PMID: 28646105; PMCID: PMC5551713.
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PubMed Mentions:
34 Fields:
Translation:
HumansCells
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GSK3-mediated CLASP2 phosphorylation modulates kinetochore dynamics. J Cell Sci. 2017 04 15; 130(8):1404-1412.
Pemble H, Kumar P, van Haren J, Wittmann T. PMID: 28232523; PMCID: PMC5399784.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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Autophagy in adhesion and migration. J Cell Sci. 2016 10 15; 129(20):3685-3693.
Kenific CM, Wittmann T, Debnath J. PMID: 27672021; PMCID: PMC5087656.
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PubMed Mentions:
41 Fields:
Translation:
HumansAnimalsCells
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Doublecortin Is Excluded from Growing Microtubule Ends and Recognizes the GDP-Microtubule Lattice. Curr Biol. 2016 06 20; 26(12):1549-1555.
Ettinger A, van Haren J, Ribeiro SA, Wittmann T. PMID: 27238282; PMCID: PMC5023073.
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PubMed Mentions:
20 Fields:
Translation:
HumansCells
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NBR1 enables autophagy-dependent focal adhesion turnover. J Cell Biol. 2016 Feb 29; 212(5):577-90.
Kenific CM, Stehbens SJ, Goldsmith J, Leidal AM, Faure N, Ye J, Wittmann T, Debnath J. PMID: 26903539; PMCID: PMC4772495.
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PubMed Mentions:
64 Fields:
Translation:
HumansAnimalsCells
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Migration of Founder Epithelial Cells Drives Proper Molar Tooth Positioning and Morphogenesis. Dev Cell. 2015 Dec 21; 35(6):713-24.
Prochazka J, Prochazkova M, Du W, Spoutil F, Tureckova J, Hoch R, Shimogori T, Sedlacek R, Rubenstein JL, Wittmann T, Klein OD. PMID: 26702830; PMCID: PMC4710359.
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PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
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Enzymatically Generated CRISPR Libraries for Genome Labeling and Screening. Dev Cell. 2015 Aug 10; 34(3):373-8.
Lane AB, Strzelecka M, Ettinger A, Grenfell AW, Wittmann T, Heald R. PMID: 26212133; PMCID: PMC4536113.
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PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
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Acetylcholine receptor (AChR) clustering is regulated both by glycogen synthase kinase 3β (GSK3β)-dependent phosphorylation and the level of CLIP-associated protein 2 (CLASP2) mediating the capture of microtubule plus-ends. J Biol Chem. 2014 Oct 31; 289(44):30857-30867.
Basu S, Sladecek S, Pemble H, Wittmann T, Slotman JA, van Cappellen W, Brenner HR, Galjart N. PMID: 25231989; PMCID: PMC4215261.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Neuronal deletion of GSK3β increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2. BMC Biol. 2014 Jun 12; 12:47.
Liz MA, Mar FM, Santos TE, Pimentel HI, Marques AM, Morgado MM, Vieira S, Sousa VF, Pemble H, Wittmann T, Sutherland C, Woodgett JR, Sousa MM. PMID: 24923837; PMCID: PMC4229956.
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PubMed Mentions:
29 Fields:
Translation:
AnimalsCells
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CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover. Nat Cell Biol. 2014 Jun; 16(6):561-73.
Stehbens SJ, Paszek M, Pemble H, Ettinger A, Gierke S, Wittmann T. PMID: 24859005; PMCID: PMC4108447.
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PubMed Mentions:
104 Fields:
Translation:
HumansCells
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Host cell polarity proteins participate in innate immunity to Pseudomonas aeruginosa infection. Cell Host Microbe. 2014 May 14; 15(5):636-43.
Tran CS, Eran Y, Ruch TR, Bryant DM, Datta A, Brakeman P, Kierbel A, Wittmann T, Metzger RJ, Mostov KE, Engel JN. PMID: 24832456; PMCID: PMC4062193.
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PubMed Mentions:
24 Fields:
Translation:
HumansCells
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Expression of an expanded CGG-repeat RNA in a single pair of primary sensory neurons impairs olfactory adaptation in Caenorhabditis elegans. Hum Mol Genet. 2014 Sep 15; 23(18):4945-59.
Juang BT, Ludwig AL, Benedetti KL, Gu C, Collins K, Morales C, Asundi A, Wittmann T, L'Etoile N, Hagerman PJ. PMID: 24821701; PMCID: PMC4140470.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Concepts in quantitative fluorescence microscopy. Methods Cell Biol. 2014; 123:1-18.
Waters JC, Wittmann T. PMID: 24974019.
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PubMed Mentions:
9 Fields:
Translation:
Cells
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Analysis of focal adhesion turnover: a quantitative live-cell imaging example. Methods Cell Biol. 2014; 123:335-46.
Stehbens SJ, Wittmann T. PMID: 24974036; PMCID: PMC4198331.
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PubMed Mentions:
18 Fields:
Translation:
HumansCells
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Quantitative imaging in cell biology. Preface. Methods Cell Biol. 2014; 123:xix-xx.
Waters JC, Wittmann T. PMID: 24974047.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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Fluorescence live cell imaging. Methods Cell Biol. 2014; 123:77-94.
Ettinger A, Wittmann T. PMID: 24974023; PMCID: PMC4198327.
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PubMed Mentions:
64 Fields:
Translation:
HumansAnimalsCells
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Light-Modulated Cell Adhesion to Control Cell and Tissue Morphogenesis. Biophysical Journal. 2014 Jan 1; 106(2):789a.
van Haren vJ, Wittmann WT. .
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LIS1 controls mitosis and mitotic spindle organization via the LIS1-NDEL1-dynein complex. Hum Mol Genet. 2014 Jan 15; 23(2):449-66.
Moon HM, Youn YH, Pemble H, Yingling J, Wittmann T, Wynshaw-Boris A. PMID: 24030547; PMCID: PMC3869364.
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PubMed Mentions:
34 Fields:
Translation:
HumansAnimalsCells
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Host microtubule plus-end binding protein CLASP1 influences sequential steps in the Trypanosoma cruzi infection process. Cell Microbiol. 2013 Apr; 15(4):571-84.
Zhao X, Kumar P, Shah-Simpson S, Caradonna KL, Galjart N, Teygong C, Blader I, Wittmann T, Burleigh BA. PMID: 23107073; PMCID: PMC3582772.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Microtubule dynamics regulation contributes to endothelial morphogenesis. Bioarchitecture. 2012 Nov-Dec; 2(6):220-7.
Lyle KS, Corleto JA, Wittmann T. PMID: 23267416; PMCID: PMC3527317.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Targeting and transport: how microtubules control focal adhesion dynamics. J Cell Biol. 2012 Aug 20; 198(4):481-9.
Stehbens S, Wittmann T. PMID: 22908306; PMCID: PMC3514042.
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PubMed Mentions:
104 Fields:
Translation:
HumansAnimalsCells
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+TIPs: SxIPping along microtubule ends. Trends Cell Biol. 2012 Aug; 22(8):418-28.
Kumar P, Wittmann T. PMID: 22748381; PMCID: PMC3408562.
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PubMed Mentions:
68 Fields:
Translation:
HumansAnimalsCells
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EB1-recruited microtubule +TIP complexes coordinate protrusion dynamics during 3D epithelial remodeling. Curr Biol. 2012 May 08; 22(9):753-62.
Gierke S, Wittmann T. PMID: 22483942; PMCID: PMC3350573.
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PubMed Mentions:
33 Fields:
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Multisite phosphorylation disrupts arginine-glutamate salt bridge networks required for binding of cytoplasmic linker-associated protein 2 (CLASP2) to end-binding protein 1 (EB1). J Biol Chem. 2012 May 18; 287(21):17050-17064.
Kumar P, Chimenti MS, Pemble H, Schönichen A, Thompson O, Jacobson MP, Wittmann T. PMID: 22467876; PMCID: PMC3366819.
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PubMed Mentions:
50 Fields:
Translation:
HumansCells
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Imaging intracellular protein dynamics by spinning disk confocal microscopy. Methods Enzymol. 2012; 504:293-313.
Stehbens S, Pemble H, Murrow L, Wittmann T. PMID: 22264541; PMCID: PMC3495241.
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PubMed Mentions:
34 Fields:
Translation:
HumansAnimalsCells
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Dynamic actin remodeling during epithelial-mesenchymal transition depends on increased moesin expression. Mol Biol Cell. 2011 Dec; 22(24):4750-64.
Haynes J, Srivastava J, Madson N, Wittmann T, Barber DL. PMID: 22031288; PMCID: PMC3237619.
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PubMed Mentions:
107 Fields:
Translation:
HumansAnimalsCells
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Chlamydia trachomatis co-opts GBF1 and CERT to acquire host sphingomyelin for distinct roles during intracellular development. PLoS Pathog. 2011 Sep; 7(9):e1002198.
Elwell CA, Jiang S, Kim JH, Lee A, Wittmann T, Hanada K, Melancon P, Engel JN. PMID: 21909260; PMCID: PMC3164637.
View in:
PubMed Mentions:
104 Fields:
Translation:
HumansCells
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Analysis of microtubule dynamic instability using a plus-end growth marker. Nat Methods. 2010 Sep; 7(9):761-8.
Matov A, Applegate K, Kumar P, Thoma C, Krek W, Danuser G, Wittmann T. PMID: 20729842; PMCID: PMC3032800.
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PubMed Mentions:
103 Fields:
Translation:
HumansCells
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Analysis of microtubule polymerization dynamics in live cells. Methods Cell Biol. 2010; 97:15-33.
Gierke S, Kumar P, Wittmann T. PMID: 20719263; PMCID: PMC3495240.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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GSK3beta phosphorylation modulates CLASP-microtubule association and lamella microtubule attachment. J Cell Biol. 2009 Mar 23; 184(6):895-908.
Kumar P, Lyle KS, Gierke S, Matov A, Danuser G, Wittmann T. PMID: 19289791; PMCID: PMC2699158.
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PubMed Mentions:
103 Fields:
Translation:
HumansCells
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SnapShot: Microtubule regulators II. Cell. 2009 Feb 06; 136(3):566, 566.e1.
Lyle K, Kumar P, Wittmann T. PMID: 19203588; PMCID: PMC4019436.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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SnapShot: Microtubule Regulators I. Cell. 2009 Jan 23; 136(2):380, 380.e1.
Lyle K, Kumar P, Wittmann T. PMID: 19167337; PMCID: PMC4019432.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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EBs clip CLIPs to growing microtubule ends. J Cell Biol. 2008 Dec 29; 183(7):1183-5.
Wittmann T. PMID: 19103811; PMCID: PMC2606966.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Cofilin activity downstream of Pak1 regulates cell protrusion efficiency by organizing lamellipodium and lamella actin networks. Dev Cell. 2007 Nov; 13(5):646-662.
Delorme V, Machacek M, DerMardirossian C, Anderson KL, Wittmann T, Hanein D, Waterman-Storer C, Danuser G, Bokoch GM. PMID: 17981134; PMCID: PMC2170459.
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PubMed Mentions:
103 Fields:
Translation:
HumansCells
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Adenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1. Mol Biol Cell. 2006 May; 17(5):2331-45.
Kita K, Wittmann T, Näthke IS, Waterman-Storer CM. PMID: 16525027; PMCID: PMC1446093.
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PubMed Mentions:
50 Fields:
Translation:
HumansAnimalsCells
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Correction. The Journal of Cell Biology. 2005 Oct 24; 171(2):393-393.
Wittmann WT, Waterman-Storer WC. .
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Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3beta in migrating epithelial cells. J Cell Biol. 2005 Jun 20; 169(6):929-39.
Wittmann T, Waterman-Storer CM. PMID: 15955847; PMCID: PMC2171640.
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PubMed Mentions:
101 Fields:
Translation:
AnimalsCells
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Microtubule cytoskeleton: a new twist at the end. Curr Biol. 2005 Feb 22; 15(4):R126-9.
Wittmann T, Desai A. PMID: 15723782.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Eg5 causes elongation of meiotic spindles when flux-associated microtubule depolymerization is blocked. Curr Biol. 2004 Nov 09; 14(21):1941-5.
Shirasu-Hiza M, Perlman ZE, Wittmann T, Karsenti E, Mitchison TJ. PMID: 15530396.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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Characterization of the TPX2 domains involved in microtubule nucleation and spindle assembly in Xenopus egg extracts. Mol Biol Cell. 2004 Dec; 15(12):5318-28.
Brunet S, Sardon T, Zimmerman T, Wittmann T, Pepperkok R, Karsenti E, Vernos I. PMID: 15385625; PMCID: PMC532013.
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PubMed Mentions:
54 Fields:
Translation:
AnimalsCells
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Regulation of Microtubule Dynamics in Migrating Cells: A New Role for Rho GTPases. Cell Motility. 2004 Jan 29; 203-217.
Wittmann WT, Waterman-Storer WC. .
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Regulation of microtubule destabilizing activity of Op18/stathmin downstream of Rac1. J Biol Chem. 2004 Feb 13; 279(7):6196-203.
Wittmann T, Bokoch GM, Waterman-Storer CM. PMID: 14645234.
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PubMed Mentions:
103 Fields:
Translation:
HumansAnimalsCells
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Regulation of leading edge microtubule and actin dynamics downstream of Rac1. J Cell Biol. 2003 Jun 09; 161(5):845-51.
Wittmann T, Bokoch GM, Waterman-Storer CM. PMID: 12796474; PMCID: PMC2172968.
View in:
PubMed Mentions:
111 Fields:
Translation:
AnimalsCells
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A high-speed multispectral spinning-disk confocal microscope system for fluorescent speckle microscopy of living cells. Methods. 2003 Jan; 29(1):29-41.
Adams MC, Salmon WC, Gupton SL, Cohan CS, Wittmann T, Prigozhina N, Waterman-Storer CM. PMID: 12543069.
View in:
PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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Toward reconstitution of in vivo microtubule dynamics in vitro. Bioessays. 2002 Apr; 24(4):305-7.
Andersen SS, Wittmann T. PMID: 11948616.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Cell motility: can Rho GTPases and microtubules point the way? J Cell Sci. 2001 Nov; 114(Pt 21):3795-803.
Wittmann T, Waterman-Storer CM. PMID: 11719546.
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PubMed Mentions:
161 Fields:
Translation:
HumansAnimalsCells
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The spindle: a dynamic assembly of microtubules and motors. Nat Cell Biol. 2001 Jan; 3(1):E28-34.
Wittmann T, Hyman A, Desai A. PMID: 11146647.
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PubMed Mentions:
165 Fields:
Translation:
HumansAnimalsCells
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TPX2, A novel xenopus MAP involved in spindle pole organization. J Cell Biol. 2000 Jun 26; 149(7):1405-18.
Wittmann T, Wilm M, Karsenti E, Vernos I. PMID: 10871281; PMCID: PMC2175143.
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PubMed Mentions:
159 Fields:
Translation:
AnimalsCells
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Motor proteins regulate force interactions between microtubules and microfilaments in the axon. Nat Cell Biol. 2000 May; 2(5):276-80.
Ahmad FJ, Hughey J, Wittmann T, Hyman A, Greaser M, Baas PW. PMID: 10806478.
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PubMed Mentions:
68 Fields:
Translation:
AnimalsCells
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Recombinant p50/dynamitin as a tool to examine the role of dynactin in intracellular processes. Methods Cell Biol. 1999; 61:137-43.
Wittmann T, Hyman T. PMID: 9891312.
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PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
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Localization of the kinesin-like protein Xklp2 to spindle poles requires a leucine zipper, a microtubule-associated protein, and dynein. J Cell Biol. 1998 Nov 02; 143(3):673-85.
Wittmann T, Boleti H, Antony C, Karsenti E, Vernos I. PMID: 9813089; PMCID: PMC2148133.
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PubMed Mentions:
84 Fields:
Translation:
HumansAnimalsCells
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Purification and characterization of full-length mammalian poly(A) polymerase. Biochim Biophys Acta. 1997 Feb 28; 1350(3):293-305.
Wittmann T, Wahle E. PMID: 9061026.
View in:
PubMed Mentions:
4 Fields:
Translation:
AnimalsCells