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Dyche Mullins, PhD

Title(s)Professor, Cellular Molecular Pharmacology
SchoolSchool of Medicine
Phone415-502-4838
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    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    Resource for Biocomputing, Visualization, and Informatics
    NIH/NCRR P41RR001081Jun 1, 1976 - Sep 14, 2012
    Role: Co-Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Yang B, Chen X, Wang Y, Feng S, Pessino V, Stuurman N, Cho NH, Cheng KW, Lord SJ, Xu L, Xie D, Mullins RD, Leonetti MD, Huang B. Epi-illumination SPIM for volumetric imaging with high spatial-temporal resolution. Nat Methods. 2019 06; 16(6):501-504. PMID: 31061492.
      View in: PubMed
    2. Mullins RD, Bieling P, Fletcher DA. From solution to surface to filament: actin flux into branched networks. Biophys Rev. 2018 Dec; 10(6):1537-1551. PMID: 30470968.
      View in: PubMed
    3. Hu X, Mullins RD. LC3 and STRAP regulate actin filament assembly by JMY during autophagosome formation. J Cell Biol. 2019 01 07; 218(1):251-266. PMID: 30420355.
      View in: PubMed
    4. Bieling P, Hansen SD, Akin O, Li TD, Hayden CC, Fletcher DA, Mullins RD. WH2 and proline-rich domains of WASP-family proteins collaborate to accelerate actin filament elongation. EMBO J. 2018 01 04; 37(1):102-121. PMID: 29141912.
      View in: PubMed
    5. Fritz-Laylin LK, Riel-Mehan M, Chen BC, Lord SJ, Goddard TD, Ferrin TE, Nicholson-Dykstra SM, Higgs H, Johnson GT, Betzig E, Mullins RD. Actin-based protrusions of migrating neutrophils are intrinsically lamellar and facilitate direction changes. Elife. 2017 09 26; 6. PMID: 28948912.
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    6. Fritz-Laylin LK, Lord SJ, Mullins RD. Our evolving view of cell motility. Cell Cycle. 2017 10 02; 16(19):1735-1736. PMID: 28820330.
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    7. Fritz-Laylin LK, Lord SJ, Mullins RD. WASP and SCAR are evolutionarily conserved in actin-filled pseudopod-based motility. J Cell Biol. 2017 06 05; 216(6):1673-1688. PMID: 28473602.
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    8. Bieling P, Li TD, Weichsel J, McGorty R, Jreij P, Huang B, Fletcher DA, Mullins RD. Force Feedback Controls Motor Activity and Mechanical Properties of Self-Assembling Branched Actin Networks. Cell. 2016 Jan 14; 164(1-2):115-127. PMID: 26771487.
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    9. Belin BJ, Goins LM, Mullins RD. Comparative analysis of tools for live cell imaging of actin network architecture. Bioarchitecture. 2014; 4(6):189-202. PMID: 26317264.
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    10. Hansen SD, Mullins RD. Lamellipodin promotes actin assembly by clustering Ena/VASP proteins and tethering them to actin filaments. Elife. 2015 Aug 21; 4. PMID: 26295568.
      View in: PubMed
    11. Belin BJ, Lee T, Mullins RD. DNA damage induces nuclear actin filament assembly by Formin -2 and Spire-½ that promotes efficient DNA repair. [corrected]. Elife. 2015 Aug 19; 4:e07735. PMID: 26287480.
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    12. Hsiao JY, Goins LM, Petek NA, Mullins RD. Arp2/3 complex and cofilin modulate binding of tropomyosin to branched actin networks. Curr Biol. 2015 Jun 15; 25(12):1573-82. PMID: 26028436.
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    13. Goins LM, Mullins RD. A novel tropomyosin isoform functions at the mitotic spindle and Golgi in Drosophila. Mol Biol Cell. 2015 Jul 01; 26(13):2491-504. PMID: 25971803.
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    14. Krishnan S, Miller RM, Tian B, Mullins RD, Jacobson MP, Taunton J. Design of reversible, cysteine-targeted Michael acceptors guided by kinetic and computational analysis. J Am Chem Soc. 2014 Sep 10; 136(36):12624-30. PMID: 25153195.
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    15. Polka JK, Kollman JM, Mullins RD. Accessory factors promote AlfA-dependent plasmid segregation by regulating filament nucleation, disassembly, and bundling. Proc Natl Acad Sci U S A. 2014 Feb 11; 111(6):2176-81. PMID: 24481252.
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    16. Petek NA, Mullins RD. Bacterial actin-like proteins: purification and characterization of self-assembly properties. Methods Enzymol. 2014; 540:19-34. PMID: 24630099.
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    17. Hansen SD, Kwiatkowski AV, Ouyang CY, Liu H, Pokutta S, Watkins SC, Volkmann N, Hanein D, Weis WI, Mullins RD, Nelson WJ. aE-catenin actin-binding domain alters actin filament conformation and regulates binding of nucleation and disassembly factors. Mol Biol Cell. 2013 Dec; 24(23):3710-20. PMID: 24068324.
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    18. Belin BJ, Mullins RD. What we talk about when we talk about nuclear actin. Nucleus. 2013 Jul-Aug; 4(4):291-7. PMID: 23934079.
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    19. Belin BJ, Cimini BA, Blackburn EH, Mullins RD. Visualization of actin filaments and monomers in somatic cell nuclei. Mol Biol Cell. 2013 Apr; 24(7):982-94. PMID: 23447706.
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    20. Ingerman E, Hsiao JY, Mullins RD. Arp2/3 complex ATP hydrolysis promotes lamellipodial actin network disassembly but is dispensable for assembly. J Cell Biol. 2013 Mar 04; 200(5):619-33. PMID: 23439681.
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    21. Hansen SD, Zuchero JB, Mullins RD. Cytoplasmic actin: purification and single molecule assembly assays. Methods Mol Biol. 2013; 1046:145-70. PMID: 23868587.
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    22. Mullins RD, Hansen SD. In vitro studies of actin filament and network dynamics. Curr Opin Cell Biol. 2013 Feb; 25(1):6-13. PMID: 23267766.
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    23. Vale RD, DeRisi J, Phillips R, Mullins RD, Waterman C, Mitchison TJ. Graduate education. Interdisciplinary graduate training in teaching labs. Science. 2012 Dec 21; 338(6114):1542-3. PMID: 23258877.
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    24. Mullins RD. The instability of stabilization. Proc Natl Acad Sci U S A. 2012 Jul 03; 109(27):10743-4. PMID: 22733745.
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    25. Zuchero JB, Belin B, Mullins RD. Actin binding to WH2 domains regulates nuclear import of the multifunctional actin regulator JMY. Mol Biol Cell. 2012 Mar; 23(5):853-63. PMID: 22262458.
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    26. Rivera CR, Kollman JM, Polka JK, Agard DA, Mullins RD. Architecture and assembly of a divergent member of the ParM family of bacterial actin-like proteins. J Biol Chem. 2011 Apr 22; 286(16):14282-90. PMID: 21339292.
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    27. Hansen SD, Mullins RD. VASP is a processive actin polymerase that requires monomeric actin for barbed end association. J Cell Biol. 2010 Nov 01; 191(3):571-84. PMID: 21041447.
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    28. Fletcher DA, Mullins RD. Cell mechanics and the cytoskeleton. Nature. 2010 Jan 28; 463(7280):485-92. PMID: 20110992.
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    29. Mullins RD. Cytoskeletal mechanisms for breaking cellular symmetry. Cold Spring Harb Perspect Biol. 2010 Jan; 2(1):a003392. PMID: 20182610.
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    30. Dayel MJ, Akin O, Landeryou M, Risca V, Mogilner A, Mullins RD. In silico reconstitution of actin-based symmetry breaking and motility. PLoS Biol. 2009 Sep; 7(9):e1000201. PMID: 19771152.
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    31. Galkin VE, Orlova A, Rivera C, Mullins RD, Egelman EH. Structural polymorphism of the ParM filament and dynamic instability. Structure. 2009 Sep 09; 17(9):1253-64. PMID: 19748346.
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    32. Polka JK, Kollman JM, Agard DA, Mullins RD. The structure and assembly dynamics of plasmid actin AlfA imply a novel mechanism of DNA segregation. J Bacteriol. 2009 Oct; 191(20):6219-30. PMID: 19666709.
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    33. Zuchero JB, Coutts AS, Quinlan ME, Thangue NB, Mullins RD. p53-cofactor JMY is a multifunctional actin nucleation factor. Nat Cell Biol. 2009 Apr; 11(4):451-9. PMID: 19287377.
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    34. Mullins RD. Bacterial Chromosome Segregation. Annu Rev Cell Dev Biol. 2009 Jan 12. PMID: 19575665.
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    35. LeClaire LL, Baumgartner M, Iwasa JH, Mullins RD, Barber DL. Phosphorylation of the Arp2/3 complex is necessary to nucleate actin filaments. J Cell Biol. 2008 Aug 25; 182(4):647-54. PMID: 18725535.
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    36. Choi CL, Claridge SA, Garner EC, Alivisatos AP, Mullins RD. Protein-nanocrystal conjugates support a single filament polymerization model in R1 plasmid segregation. J Biol Chem. 2008 Oct 17; 283(42):28081-6. PMID: 18658133.
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    37. Sallee NA, Rivera GM, Dueber JE, Vasilescu D, Mullins RD, Mayer BJ, Lim WA. The pathogen protein EspF(U) hijacks actin polymerization using mimicry and multivalency. Nature. 2008 Aug 21; 454(7207):1005-8. PMID: 18650806.
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    38. Akin O, Mullins RD. Capping protein increases the rate of actin-based motility by promoting filament nucleation by the Arp2/3 complex. Cell. 2008 May 30; 133(5):841-51. PMID: 18510928.
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    39. Mullins RD. Trapping fugitive filament formers. Structure. 2008 May; 16(5):661-3. PMID: 18462670.
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    40. Campbell CS, Mullins RD. In vivo visualization of type II plasmid segregation: bacterial actin filaments pushing plasmids. J Cell Biol. 2007 Dec 03; 179(5):1059-66. PMID: 18039937.
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    41. Quinlan ME, Hilgert S, Bedrossian A, Mullins RD, Kerkhoff E. Regulatory interactions between two actin nucleators, Spire and Cappuccino. J Cell Biol. 2007 Oct 08; 179(1):117-28. PMID: 17923532.
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    42. Orlova A, Garner EC, Galkin VE, Heuser J, Mullins RD, Egelman EH. The structure of bacterial ParM filaments. Nat Struct Mol Biol. 2007 Oct; 14(10):921-6. PMID: 17873883.
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    43. Iwasa JH, Mullins RD. Spatial and temporal relationships between actin-filament nucleation, capping, and disassembly. Curr Biol. 2007 Mar 06; 17(5):395-406. PMID: 17331727.
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    44. Garner EC, Campbell CS, Weibel DB, Mullins RD. Reconstitution of DNA segregation driven by assembly of a prokaryotic actin homolog. Science. 2007 Mar 02; 315(5816):1270-4. PMID: 17332412.
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    45. Loomis PA, Kelly AE, Zheng L, Changyaleket B, Sekerková G, Mugnaini E, Ferreira A, Mullins RD, Bartles JR. Targeted wild-type and jerker espins reveal a novel, WH2-domain-dependent way to make actin bundles in cells. J Cell Sci. 2006 Apr 15; 119(Pt 8):1655-65. PMID: 16569662.
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    46. Kelly AE, Kranitz H, Dötsch V, Mullins RD. Actin binding to the central domain of WASP/Scar proteins plays a critical role in the activation of the Arp2/3 complex. J Biol Chem. 2006 Apr 14; 281(15):10589-97. PMID: 16403731.
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    47. Quinlan ME, Heuser JE, Kerkhoff E, Mullins RD. Drosophila Spire is an actin nucleation factor. Nature. 2005 Jan 27; 433(7024):382-8. PMID: 15674283.
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    48. Garner EC, Campbell CS, Mullins RD. Dynamic instability in a DNA-segregating prokaryotic actin homolog. Science. 2004 Nov 05; 306(5698):1021-5. PMID: 15528442.
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    49. Dayel MJ, Mullins RD. Activation of Arp2/3 complex: addition of the first subunit of the new filament by a WASP protein triggers rapid ATP hydrolysis on Arp2. PLoS Biol. 2004 Apr; 2(4):E91. PMID: 15094799.
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    50. Welch MD, Mullins RD. Cellular control of actin nucleation. Annu Rev Cell Dev Biol. 2002; 18:247-88. PMID: 12142287.
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    51. Dayel MJ, Holleran EA, Mullins RD. Arp2/3 complex requires hydrolyzable ATP for nucleation of new actin filaments. Proc Natl Acad Sci U S A. 2001 Dec 18; 98(26):14871-6. PMID: 11752435.
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    52. Zalevsky J, Lempert L, Kranitz H, Mullins RD. Different WASP family proteins stimulate different Arp2/3 complex-dependent actin-nucleating activities. Curr Biol. 2001 Dec 11; 11(24):1903-13. PMID: 11747816.
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    53. Shahidain R, Mullins RD, Sisken JE. Calcium spiking activity and baseline calcium levels in ROS 17/2.8 cells exposed to extremely low frequency electromagnetic fields (ELF EMF). Int J Radiat Biol. 2001 Feb; 77(2):241-8. PMID: 11236931.
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    54. Pollard TD, Blanchoin L, Mullins RD. Actin dynamics. J Cell Sci. 2001 Jan; 114(Pt 1):3-4. PMID: 11112680.
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    55. Prehoda KE, Scott JA, Mullins RD, Lim WA. Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex. Science. 2000 Oct 27; 290(5492):801-6. PMID: 11052943.
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    56. Blanchoin L, Pollard TD, Mullins RD. Interactions of ADF/cofilin, Arp2/3 complex, capping protein and profilin in remodeling of branched actin filament networks. Curr Biol. 2000 Oct 19; 10(20):1273-82. PMID: 11069108.
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    57. Zalevsky J, Grigorova I, Mullins RD. Activation of the Arp2/3 complex by the Listeria acta protein. Acta binds two actin monomers and three subunits of the Arp2/3 complex. J Biol Chem. 2001 Feb 02; 276(5):3468-75. PMID: 11029465.
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    58. Mullins RD, Sisken JE. Mechanisms underlying spontaneous calcium spiking in aequorin-loaded ROS 17/2.8 cells. Bioelectromagnetics. 2000 Jul; 21(5):329-37. PMID: 10899768.
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    59. DeFea KA, Zalevsky J, Thoma MS, Déry O, Mullins RD, Bunnett NW. beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2. J Cell Biol. 2000 Mar 20; 148(6):1267-81. PMID: 10725339.
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    60. Mullins RD. How WASP-family proteins and the Arp2/3 complex convert intracellular signals into cytoskeletal structures. Curr Opin Cell Biol. 2000 Feb; 12(1):91-6. PMID: 10679362.
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    61. Mullins RD, Machesky LM. Actin assembly mediated by Arp2/3 complex and WASP family proteins. Methods Enzymol. 2000; 325:214-37. PMID: 11036606.
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    62. Pollard TD, Blanchoin L, Mullins RD. Molecular mechanisms controlling actin filament dynamics in nonmuscle cells. Annu Rev Biophys Biomol Struct. 2000; 29:545-76. PMID: 10940259.
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    63. Mullins RD, Pollard TD. Rho-family GTPases require the Arp2/3 complex to stimulate actin polymerization in Acanthamoeba extracts. Curr Biol. 1999 Apr 22; 9(8):405-15. PMID: 10226024.
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    64. Mullins RD, Pollard TD. Structure and function of the Arp2/3 complex. Curr Opin Struct Biol. 1999 Apr; 9(2):244-9. PMID: 10322212.
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    65. Machesky LM, Mullins RD, Higgs HN, Kaiser DA, Blanchoin L, May RC, Hall ME, Pollard TD. Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex. Proc Natl Acad Sci U S A. 1999 Mar 30; 96(7):3739-44. PMID: 10097107.
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    66. Mullins RD, Heuser JA, Pollard TD. The interaction of Arp2/3 complex with actin: nucleation, high affinity pointed end capping, and formation of branching networks of filaments. Proc Natl Acad Sci U S A. 1998 May 26; 95(11):6181-6. PMID: 9600938.
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    67. Mullins RD, Kelleher JF, Xu J, Pollard TD. Arp2/3 complex from Acanthamoeba binds profilin and cross-links actin filaments. Mol Biol Cell. 1998 Apr; 9(4):841-52. PMID: 9529382.
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    68. Kelleher JF, Mullins RD, Pollard TD. Purification and assay of the Arp2/3 complex from Acanthamoeba castellanii. Methods Enzymol. 1998; 298:42-51. PMID: 9751870.
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    69. Mullins RD, Stafford WF, Pollard TD. Structure, subunit topology, and actin-binding activity of the Arp2/3 complex from Acanthamoeba. J Cell Biol. 1997 Jan 27; 136(2):331-43. PMID: 9015304.
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    70. Mullins RD, Kelleher JF, Pollard TD. Actin' like actin? Trends Cell Biol. 1996 Jun; 6(6):208-12. PMID: 15157457.
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    71. McCoy KR, Mullins RD, Newcomb TG, Ng GM, Pavlínková G, Polinsky RJ, Nee LE, Sisken JE. Serum- and bradykinin-induced calcium transients in familial Alzheimer's fibroblasts. Neurobiol Aging. 1993 Sep-Oct; 14(5):447-55. PMID: 8247227.
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    72. Newcomb TG, Mullins RD, Sisken JE. Altered calcium regulation in SV40-transformed Swiss 3T3 fibroblasts. Cell Calcium. 1993 Jul; 14(7):539-49. PMID: 8402837.
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    73. Mullins RD, Sisken JE, Hejase HA, Sisken BF. Design and characterization of a system for exposure of cultured cells to extremely low frequency electric and magnetic fields over a wide range of field strengths. Bioelectromagnetics. 1993; 14(2):173-86. PMID: 8494558.
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