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Dyche Mullins, PhD

Title(s)Howard Hughes Investigator, Cellular Molecular Pharmacology
SchoolSchool of Medicine
Address600 16th Street
San Francisco CA 94158
Phone415-514-0133
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    Dyche Mullins studies the assembly and regulation of cytoskeletal networks—collections of molecules used by living cells to move molecular cargo, establish polarity, and propel themselves forward. Understanding how cells construct their internal molecular "skeletons" is key to understanding a wide variety of biological processes and human diseases.

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    Assembly and function of cytoskeletal systems in eukaryotic and prokaryotic cells
    NIH R35GM118119Apr 15, 2016 - Mar 31, 2021
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    Resource for Biocomputing, Visualization, and Informatics
    NIH/NCRR P41RR001081Jun 1, 1976 - Sep 14, 2012
    Role: Co-Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. From solution to surface to filament: actin flux into branched networks. Biophys Rev. 2018 Dec; 10(6):1537-1551. Mullins RD, Bieling P, Fletcher DA. PMID: 30470968.
      View in: PubMed   Mentions:
    2. WH2 and proline-rich domains of WASP-family proteins collaborate to accelerate actin filament elongation. EMBO J. 2018 01 04; 37(1):102-121. Bieling P, Hansen SD, Akin O, Li TD, Hayden CC, Fletcher DA, Mullins RD. PMID: 29141912.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    3. Cell mechanics and the cytoskeleton. Nature. 2010 Jan 28; 463(7280):485-92. Fletcher DA, Mullins RD. PMID: 20110992.
      View in: PubMed   Mentions: 489     Fields:    Translation:HumansAnimalsCells
    4. In silico reconstitution of actin-based symmetry breaking and motility. PLoS Biol. 2009 Sep; 7(9):e1000201. Dayel MJ, Akin O, Landeryou M, Risca V, Mogilner A, Mullins RD. PMID: 19771152.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    5. Structural polymorphism of the ParM filament and dynamic instability. Structure. 2009 Sep 09; 17(9):1253-64. Galkin VE, Orlova A, Rivera C, Mullins RD, Egelman EH. PMID: 19748346.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    6. p53-cofactor JMY is a multifunctional actin nucleation factor. Nat Cell Biol. 2009 Apr; 11(4):451-9. Zuchero JB, Coutts AS, Quinlan ME, Thangue NB, Mullins RD. PMID: 19287377.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansAnimalsCells
    7. Bacterial Chromosome Segregation. Annu Rev Cell Dev Biol. 2009 Jan 12. Mullins RD. PMID: 19575665.
      View in: PubMed   Mentions:    Fields:    
    8. Protein-nanocrystal conjugates support a single filament polymerization model in R1 plasmid segregation. J Biol Chem. 2008 Oct 17; 283(42):28081-6. Choi CL, Claridge SA, Garner EC, Alivisatos AP, Mullins RD. PMID: 18658133.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    9. Trapping fugitive filament formers. Structure. 2008 May; 16(5):661-3. Mullins RD. PMID: 18462670.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    10. Regulatory interactions between two actin nucleators, Spire and Cappuccino. J Cell Biol. 2007 Oct 08; 179(1):117-28. Quinlan ME, Hilgert S, Bedrossian A, Mullins RD, Kerkhoff E. PMID: 17923532.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    11. The structure of bacterial ParM filaments. Nat Struct Mol Biol. 2007 Oct; 14(10):921-6. Orlova A, Garner EC, Galkin VE, Heuser J, Mullins RD, Egelman EH. PMID: 17873883.
      View in: PubMed   Mentions: 40     Fields:    Translation:Cells
    12. Targeted wild-type and jerker espins reveal a novel, WH2-domain-dependent way to make actin bundles in cells. J Cell Sci. 2006 Apr 15; 119(Pt 8):1655-65. Loomis PA, Kelly AE, Zheng L, Changyaleket B, Sekerková G, Mugnaini E, Ferreira A, Mullins RD, Bartles JR. PMID: 16569662.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    13. Cellular control of actin nucleation. Annu Rev Cell Dev Biol. 2002; 18:247-88. Welch MD, Mullins RD. PMID: 12142287.
      View in: PubMed   Mentions: 159     Fields:    Translation:HumansAnimalsCells
    14. Calcium spiking activity and baseline calcium levels in ROS 17/2.8 cells exposed to extremely low frequency electromagnetic fields (ELF EMF). Int J Radiat Biol. 2001 Feb; 77(2):241-8. Shahidain R, Mullins RD, Sisken JE. PMID: 11236931.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    15. Actin dynamics. J Cell Sci. 2001 Jan; 114(Pt 1):3-4. Pollard TD, Blanchoin L, Mullins RD. PMID: 11112680.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    16. Interactions of ADF/cofilin, Arp2/3 complex, capping protein and profilin in remodeling of branched actin filament networks. Curr Biol. 2000 Oct 19; 10(20):1273-82. Blanchoin L, Pollard TD, Mullins RD. PMID: 11069108.
      View in: PubMed   Mentions: 91     Fields:    Translation:AnimalsCells
    17. Mechanisms underlying spontaneous calcium spiking in aequorin-loaded ROS 17/2.8 cells. Bioelectromagnetics. 2000 Jul; 21(5):329-37. Mullins RD, Sisken JE. PMID: 10899768.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    18. Molecular mechanisms controlling actin filament dynamics in nonmuscle cells. Annu Rev Biophys Biomol Struct. 2000; 29:545-76. Pollard TD, Blanchoin L, Mullins RD. PMID: 10940259.
      View in: PubMed   Mentions: 486     Fields:    Translation:HumansAnimalsCells
    19. Rho-family GTPases require the Arp2/3 complex to stimulate actin polymerization in Acanthamoeba extracts. Curr Biol. 1999 Apr 22; 9(8):405-15. Mullins RD, Pollard TD. PMID: 10226024.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    20. Structure and function of the Arp2/3 complex. Curr Opin Struct Biol. 1999 Apr; 9(2):244-9. Mullins RD, Pollard TD. PMID: 10322212.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    21. Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex. Proc Natl Acad Sci U S A. 1999 Mar 30; 96(7):3739-44. Machesky LM, Mullins RD, Higgs HN, Kaiser DA, Blanchoin L, May RC, Hall ME, Pollard TD. PMID: 10097107.
      View in: PubMed   Mentions: 240     Fields:    Translation:HumansAnimalsCells
    22. The interaction of Arp2/3 complex with actin: nucleation, high affinity pointed end capping, and formation of branching networks of filaments. Proc Natl Acad Sci U S A. 1998 May 26; 95(11):6181-6. Mullins RD, Heuser JA, Pollard TD. PMID: 9600938.
      View in: PubMed   Mentions: 444     Fields:    Translation:AnimalsCells
    23. Arp2/3 complex from Acanthamoeba binds profilin and cross-links actin filaments. Mol Biol Cell. 1998 Apr; 9(4):841-52. Mullins RD, Kelleher JF, Xu J, Pollard TD. PMID: 9529382.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    24. Purification and assay of the Arp2/3 complex from Acanthamoeba castellanii. Methods Enzymol. 1998; 298:42-51. Kelleher JF, Mullins RD, Pollard TD. PMID: 9751870.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    25. Structure, subunit topology, and actin-binding activity of the Arp2/3 complex from Acanthamoeba. J Cell Biol. 1997 Jan 27; 136(2):331-43. Mullins RD, Stafford WF, Pollard TD. PMID: 9015304.
      View in: PubMed   Mentions: 79     Fields:    Translation:Animals
    26. Actin' like actin? Trends Cell Biol. 1996 Jun; 6(6):208-12. Mullins RD, Kelleher JF, Pollard TD. PMID: 15157457.
      View in: PubMed   Mentions: 16     Fields:    
    27. Serum- and bradykinin-induced calcium transients in familial Alzheimer's fibroblasts. Neurobiol Aging. 1993 Sep-Oct; 14(5):447-55. McCoy KR, Mullins RD, Newcomb TG, Ng GM, Pavlínková G, Polinsky RJ, Nee LE, Sisken JE. PMID: 8247227.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    28. Altered calcium regulation in SV40-transformed Swiss 3T3 fibroblasts. Cell Calcium. 1993 Jul; 14(7):539-49. Newcomb TG, Mullins RD, Sisken JE. PMID: 8402837.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    29. Design and characterization of a system for exposure of cultured cells to extremely low frequency electric and magnetic fields over a wide range of field strengths. Bioelectromagnetics. 1993; 14(2):173-86. Mullins RD, Sisken JE, Hejase HA, Sisken BF. PMID: 8494558.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
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