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Elaine Ku, MD

Title(s)Associate Professor, Medicine
SchoolSchool of Medicine
AddressLocation Required
Varies CA 00000
Phone415-476-3546
ORCID ORCID Icon0000-0002-7774-2526 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California , Los Angeles BA/BS 06/2003English/Biology
    University of California , San Diego MD 06/2007Medicine
    LAC-USC Medical Center , Los Angeles 06/2011Medicine and Pediatrics Residency
    University of California , San Francisco MAS 06/2015Clinical Research
    University of California , San Francisco 06/2015Nephrology and Pediatric Nephrology Fellowship
    Collapse Awards and Honors
    Clinical Scientist in Nephrology Award2013  - 2014American Kidney Fund
    Young Investigator Award/Satellite Clinical Investigator2016  - 2018National Kidney Foundation
    UCSF School of Medicine2019Inquiry Mentor Award for Outstanding Mentorship

    Collapse Overview 
    Collapse Overview
    The global context of my research program focuses on understanding differences in the epidemiology, clinical management, and outcomes of children versus adults with kidney disease and the conduct of clinical trials to test interventions (such as blood pressure control) that will improve survival of patients with kidney disease. I am especially interested in transitions of care, such as that between adolescence and young adulthood, as well as that between advanced chronic kidney disease and end-stage renal disease (including dialysis and transplant).

    My specific areas of focus currently include 1) cardiovascular risk in patients with kidney disease; 2) disparities in access to kidney transplantation and transplant outcomes; and 3) risk factors for progression of chronic kidney disease.

    Collapse Research 
    Collapse Research Activities and Funding
    Acute declines in kidney function during blood pressure interventions in CKD
    NIH/NIDDK R01DK121904May 1, 2020 - Feb 28, 2025
    Role: Principal Investigator
    Reaching Equity for Adults and CHildren in Transplant (REACH-TRANSPLANT)
    NIH/NIDDK R01DK120886Sep 11, 2019 - Jun 30, 2024
    Role: Principal Investigator
    Racial and ethnic disparities in access to kidney transplantation.
    NIH/NIDDK R01DK115629Dec 6, 2017 - Nov 30, 2021
    Role: Principal Investigator
    UCSF Pilot for Junior Investigators
    Resource allocation program UCSFMay 1, 2017 - Apr 30, 2018
    Role: Co-PI
    Weight trajectory and its association with adverse outcomes
    National Kidney Foundation Young Investigator AwardJul 1, 2016 - Nov 30, 2017
    Role: PI
    Blood pressure trends, outcomes, and interventions in adolescents and young adults at increased cardiovascular risk
    NIH/NHLBI K23HL131023Feb 1, 2016 - Jan 31, 2021
    Role: Principal Investigator
    Role of pre-ESRD blood pressure management on post-ESRD outcomes
    NIH/NIDDK F32DK098871Dec 1, 2014 - Nov 30, 2016
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Faculty Mentoring
    Collapse Student Projects
    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Intensive BP Control and eGFR Declines: Are These Events Due to Hemodynamic Effects and Are Changes Reversible? Curr Cardiol Rep. 2020 Aug 09; 22(10):117. Chen DC, McCallum W, Sarnak MJ, Ku E. PMID: 32772196.
      View in: PubMed   Mentions:    Fields:    
    2. Recovery of Kidney Function Among Patients With Glomerular Disease Starting Maintenance Dialysis. Am J Kidney Dis. 2020 Aug 06. Kwong YD, Liu KD, Hsu RK, Johansen KL, McCulloch CE, Seth D, Fallahzadeh MK, Grimes BA, Ku E. PMID: 32771649.
      View in: PubMed   Mentions:    Fields:    
    3. eHealth in kidney care. Nat Rev Nephrol. 2020 Jul; 16(7):368-370. Wang CS, Ku E. PMID: 32238923.
      View in: PubMed   Mentions:    Fields:    
    4. Racial and Ethnic Disparities in Kidney Transplant Access Within a Theoretical Context of Medical Eligibility. Transplantation. 2020 Jul; 104(7):1437-1444. Ku E, Lee BK, McCulloch CE, Roll GR, Grimes B, Adey D, Johansen KL. PMID: 31568216.
      View in: PubMed   Mentions:    Fields:    
    5. Pretransplant dialysis exposure and outcomes after kidney transplantation - Where quantity and quality intersect? Am J Transplant. 2020 May 14. Dinh A, Ku E. PMID: 32406189.
      View in: PubMed   Mentions:    Fields:    
    6. Tubular secretion of creatinine and kidney function: an observational study. BMC Nephrol. 2020 Mar 30; 21(1):108. Zhang X, Rule AD, McCulloch CE, Lieske JC, Ku E, Hsu CY. PMID: 32228497.
      View in: PubMed   Mentions: 1     Fields:    
    7. Prognostic Value of Ambulatory Blood Pressure Load in Pediatric CKD. Clin J Am Soc Nephrol. 2020 Apr 07; 15(4):493-500. Lee J, McCulloch CE, Flynn JT, Samuels J, Warady BA, Furth SL, Seth D, Grimes BA, Mitsnefes MM, Ku E. PMID: 32160993.
      View in: PubMed   Mentions:    Fields:    
    8. Association Between APOL1 Genotype and Need for Kidney Replacement Therapy in Patients Without Diabetes: Does Age Matter? Am J Kidney Dis. 2020 02; 75(2):294-296. Wei J, Johansen KL, McCulloch CE, Lipkowitz M, Weir M, Lin F, Campese VM, Smogorzewski M, Ku E. PMID: 31837887.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Race and Mortality in CKD and Dialysis: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis. 2020 03; 75(3):394-403. Ku E, Yang W, McCulloch CE, Feldman HI, Go AS, Lash J, Bansal N, He J, Horwitz E, Ricardo AC, Shafi T, Sondheimer J, Townsend RR, Waikar SS, Hsu CY. PMID: 31732235.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Authors' Reply. J Am Soc Nephrol. 2019 12; 30(12):2474. Winnicki E, McCulloch CE, Ku E. PMID: 31649098.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Use of ambulatory blood pressure monitoring in kidney transplant recipients. Nephrol Dial Transplant. 2019 09 01; 34(9):1437-1439. Whelan AM, Ku E. PMID: 30838404.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Effect of Blood Pressure Control on Long-Term Risk of End-Stage Renal Disease and Death Among Subgroups of Patients With Chronic Kidney Disease. J Am Heart Assoc. 2019 08 20; 8(16):e012749. Ku E, Sarnak MJ, Toto R, McCulloch CE, Lin F, Smogorzewski M, Hsu CY. PMID: 31411082.
      View in: PubMed   Mentions: 2     Fields:    
    13. Higher eGFR at Dialysis Initiation Is Not Associated with a Survival Benefit in Children. J Am Soc Nephrol. 2019 08; 30(8):1505-1513. Winnicki E, Johansen KL, Cabana MD, Warady BA, McCulloch CE, Grimes B, Ku E. PMID: 31320460.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. Starting Renal Replacement Therapy: Is It About Time? Am J Nephrol. 2019; 50(2):144-151. Ku E, McCulloch CE, Johansen KL. PMID: 31269487.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Cardiovascular disease in young adults with incident ESRD. Nat Rev Nephrol. 2019 07; 15(7):390-391. Ku E, Mitsnefes MM. PMID: 31043718.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Magnitude of the Difference Between Clinic and Ambulatory Blood Pressures and Risk of Adverse Outcomes in Patients With Chronic Kidney Disease. J Am Heart Assoc. 2019 05 07; 8(9):e011013. Ku E, Hsu RK, Tuot DS, Bae SR, Lipkowitz MS, Smogorzewski MJ, Grimes BA, Weir MR. PMID: 31014164.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    17. Association between BMI changes and mortality risk in children with end-stage renal disease. Pediatr Nephrol. 2019 09; 34(9):1557-1563. Roberts MJ, Mitsnefes MM, McCulloch CE, Greenbaum LA, Grimes BA, Ku E. PMID: 30963283.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    18. Hypertension in CKD: Core Curriculum 2019. Am J Kidney Dis. 2019 07; 74(1):120-131. Ku E, Lee BJ, Wei J, Weir MR. PMID: 30898362.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    19. Complications of Chronic Kidney Disease in Adolescents. Adolescents with Chronic Kidney Disease. 2019 Jan 1; 1-15. Elaine Ku, Jonas Kwok. .
      View in: Publisher Site   Mentions:
    20. Sex Disparities in Risk of Mortality Among Children With ESRD. Am J Kidney Dis. 2019 02; 73(2):156-162. Ahearn P, Johansen KL, McCulloch CE, Grimes BA, Ku E. PMID: 30318132.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    21. Depressive Symptoms Associate With Race and All-Cause Mortality in Patients With CKD. Kidney Int Rep. 2019 Feb; 4(2):222-230. Tuot DS, Lin F, Norris K, Gassman J, Smogorzewski M, Ku E. PMID: 30775619.
      View in: PubMed   Mentions:
    22. Use of Antihypertensive Agents and Association With Risk of Adverse Outcomes in Chronic Kidney Disease: Focus on Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers. J Am Heart Assoc. 2018 10 02; 7(19):e009992. Ku E, McCulloch CE, Vittinghoff E, Lin F, Johansen KL. PMID: 30371331.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    23. Use of Renin-Angiotensin System Blockade in Advanced CKD: An NKF-KDOQI Controversies Report. Am J Kidney Dis. 2018 12; 72(6):873-884. Weir MR, Lakkis JI, Jaar B, Rocco MV, Choi MJ, Kramer HJ, Ku E. PMID: 30201547.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    24. Acute Declines in Renal Function during Intensive BP Lowering and Long-Term Risk of Death. J Am Soc Nephrol. 2018 09; 29(9):2401-2408. Ku E, Ix JH, Jamerson K, Tangri N, Lin F, Gassman J, Smogorzewski M, Sarnak MJ. PMID: 30006417.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. Time-Centered Approach to Understanding Risk Factors for the Progression of CKD. Clin J Am Soc Nephrol. 2018 05 07; 13(5):693-701. Ku E, Johansen KL, McCulloch CE. PMID: 29602779.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    26. Changes in Blood Pressure During Young Adulthood and Subsequent Kidney Function Decline: Findings From the Coronary Artery Risk Development in Young Adulthood (CARDIA) Study. Am J Kidney Dis. 2018 08; 72(2):243-250. Ku E, Vittinghoff E, Jacobs DR, Lewis CE, Allen NB, Bibbins-Domingo K, Shlipak M, Kramer H, Peralta CA. PMID: 29510922.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    27. Twenty-Four-Hour Ambulatory Blood Pressure versus Clinic Blood Pressure Measurements and Risk of Adverse Outcomes in Children with CKD. Clin J Am Soc Nephrol. 2018 03 07; 13(3):422-428. Ku E, McCulloch CE, Warady BA, Furth SL, Grimes BA, Mitsnefes MM. PMID: 29440119.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    28. Use of the Kidney Failure Risk Equation to Determine the Risk of Progression to End-stage Renal Disease in Children With Chronic Kidney Disease. JAMA Pediatr. 2018 02 01; 172(2):174-180. Winnicki E, McCulloch CE, Mitsnefes MM, Furth SL, Warady BA, Ku E. PMID: 29255845.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    29. Longitudinal Weight Change During CKD Progression and Its Association With Subsequent Mortality. Am J Kidney Dis. 2018 05; 71(5):657-665. Ku E, Kopple JD, Johansen KL, McCulloch CE, Go AS, Xie D, Lin F, Hamm LL, He J, Kusek JW, Navaneethan SD, Ricardo AC, Rincon-Choles H, Smogorzewski M, Hsu CY. PMID: 29217305.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    30. Associations Between Weight Loss, Kidney Function Decline, and Risk of ESRD in the Chronic Kidney Disease in Children (CKiD) Cohort Study. Am J Kidney Dis. 2018 05; 71(5):648-656. Ku E, Kopple JD, McCulloch CE, Warady BA, Furth SL, Mak RH, Grimes BA, Mitsnefes M. PMID: 29132947.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    31. Patterns of blood pressure response during intensive BP lowering and clinical events: results from the secondary prevention of small subcortical strokes trial. Blood Press. 2018 04; 27(2):73-81. Ku E, Scherzer R, Odden MC, Shlipak M, White CL, Field TS, Benavente O, Pergola PE, Peralta CA. PMID: 28952798.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    32. Acute Declines in Renal Function during Intensive BP Lowering: Implications for Future ESRD Risk. J Am Soc Nephrol. 2017 Sep; 28(9):2794-2801. Ku E, Bakris G, Johansen KL, Lin F, Sarnak MJ, Campese VM, Jamerson K, Gassman JJ, Smogorzewski M, Hsu CY. PMID: 28473636.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    33. Racial and Ethnic Disparities in Survival of Children with ESRD. J Am Soc Nephrol. 2017 May; 28(5):1584-1591. Ku E, McCulloch CE, Grimes BA, Johansen KL. PMID: 28034898.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    34. Strict blood pressure control associates with decreased mortality risk by APOL1 genotype. Kidney Int. 2017 02; 91(2):443-450. Ku E, Lipkowitz MS, Appel LJ, Parsa A, Gassman J, Glidden DV, Smogorzewski M, Hsu CY. PMID: 27927600.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    35. Association Between Blood Pressure and Adverse Renal Events in Type 1 Diabetes. Diabetes Care. 2016 Dec; 39(12):2218-2224. Ku E, McCulloch CE, Mauer M, Gitelman SE, Grimes BA, Hsu CY. PMID: 27872156.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    36. BP Control and Long-Term Risk of ESRD and Mortality. J Am Soc Nephrol. 2017 02; 28(2):671-677. Ku E, Gassman J, Appel LJ, Smogorzewski M, Sarnak MJ, Glidden DV, Bakris G, Gutiérrez OM, Hebert LA, Ix JH, Lea J, Lipkowitz MS, Norris K, Ploth D, Pogue VA, Rostand SG, Siew ED, Sika M, Tisher CC, Toto R, Wright JT, Wyatt C, Hsu CY. PMID: 27516235.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    37. Height at First RRT and Mortality in Children. Clin J Am Soc Nephrol. 2016 05 06; 11(5):832-9. Ku E, Fine RN, Hsu CY, McCulloch C, Glidden DV, Grimes B, Johansen KL. PMID: 26933189.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    38. Change in Measured GFR Versus eGFR and CKD Outcomes. J Am Soc Nephrol. 2016 Jul; 27(7):2196-204. Ku E, Xie D, Shlipak M, Hyre Anderson A, Chen J, Go AS, He J, Horwitz EJ, Rahman M, Ricardo AC, Sondheimer JH, Townsend RR, Hsu CY. PMID: 26604213.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    39. Association of Body Mass Index with Patient-Centered Outcomes in Children with ESRD. J Am Soc Nephrol. 2016 Feb; 27(2):551-8. Ku E, Glidden DV, Hsu CY, Portale AA, Grimes B, Johansen KL. PMID: 26054540.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    40. State level variations in nephrology workforce and timing and incidence of dialysis in the United States among children and adults: a retrospective cohort study. BMC Nephrol. 2015 Jan 15; 16:2. Ku E, Johansen KL, Portale AA, Grimes B, Hsu CY. PMID: 25589150.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    41. Association between strict blood pressure control during chronic kidney disease and lower mortality after onset of end-stage renal disease. Kidney Int. 2015 May; 87(5):1055-60. Ku E, Glidden DV, Johansen KL, Sarnak M, Tighiouart H, Grimes B, Hsu CY. PMID: 25493952.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    42. Index of suspicion. Case 1: fever, diarrhea, jaundice, and confusion in an 18-year-old male. Case 2: severe anemia in a 6-month-old girl. Case 3: red urine in a 4-month-old boy. Pediatr Rev. 2014 Mar; 35(3):129-35. Ku E, Thomas M, Ho CH, Whipple NS, Abdul-Rahman O, Megason GC, Herrington BL, Carmody JB, Charlton JR. PMID: 24585816.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    43. Regional variation in the incidence of dialysis-requiring AKI in the United States. Clin J Am Soc Nephrol. 2013 Sep; 8(9):1476-81. Hsu RK, McCulloch CE, Ku E, Dudley RA, Hsu CY. PMID: 23929923.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    44. Is lipid management effective for all stages of CKD?. Blood Purif. 2013; 35(1-3):26-30. Ku E, Campese V. PMID: 23343543.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    45. IgA nephropathy in a patient with ulcerative colitis, Graves' disease and positive myeloperoxidase ANCA. Clin Nephrol. 2012 Feb; 77(2):146-50. Ku E, Ananthapanyasut W, Campese VM. PMID: 22257545.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    46. Do HMG-CoA reductase inhibitors improve kidney function? The saga continues. J Nephrol. 2011 Sep-Oct; 24(5):550-3. Campese VM, Ku E, Bigazzi R, Bianchi S. PMID: 21887675.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    47. Metabolic and Dietary Influences on Sympathetic Nervous System Activity. Nutritional and Metabolic Bases of Cardiovascular Disease. 2011 Feb 18; 298-302. Elaine Ku, Tanzina Nasreen, Jeanie Park, Vito M. Campese. .
      View in: Publisher Site   Mentions:
    48. Sympathetic renal innervation and resistant hypertension. Int J Hypertens. 2011 Jan 20; 2011:814354. Campese VM, Ku E, Park J. PMID: 21331158.
      View in: PubMed   Mentions:
    49. Visual diagnosis: vaginal mass in a 16-month-old child. Pediatr Rev. 2010 Aug; 31(8):337-40. Ku E, Brotherton BJ, Parrish C, Zia SK, McKenna S. PMID: 20679100.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    50. Aldosterone in the pathogenesis of chronic kidney disease and proteinuria. Curr Hypertens Rep. 2010 Aug; 12(4):303-6. Lu Y, Ku E, Campese VM. PMID: 20596805.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    51. Aldosterone and hypertension in African Americans. Am J Hypertens. 2009 Dec; 22(12):1234. Ku E, Campese VM. PMID: 19924116.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    52. The Case for Dual Renin-Angiotensin System Inhibition—Reply. JAMA Internal Medicine. 2009 Nov 9; 169(20):1931-1931. Elaine Ku, Jeanie Park, Jay Vidhun, Vito Campese. .
      View in: Publisher Site   Mentions:
    53. Anion and osmolal gaps after alcohol intoxication. Am J Kidney Dis. 2009 Aug; 54(2):385-8. Ku E, Cheung EL, Khan A, Yu AS. PMID: 19560850.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    54. The hazards of dual renin-angiotensin blockade in chronic kidney disease. Arch Intern Med. 2009 Jun 08; 169(11):1015-8. Ku E, Park J, Vidhun J, Campese V. PMID: 19506167.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    55. Lixivaptan: a novel vasopressin receptor antagonist. Expert Opin Investig Drugs. 2009 May; 18(5):657-62. Ku E, Nobakht N, Campese VM. PMID: 19379124.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    56. Role of aldosterone in the progression of chronic kidney disease and potential use of aldosterone blockade in children. Pediatr Nephrol. 2009 Dec; 24(12):2301-7. Ku E, Campese VM. PMID: 19347366.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
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