Paul Brakeman, MD, PhD

Title(s)Professor, Pediatrics
SchoolSchool of Medicine
Address550 16th Street, #4355
San Francisco CA 94158
PronounsHe/Him/His
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency School of Medicine
    John Hopkins UniversityM.D.1997School of Medicine
    Collapse Awards and Honors
    San Francisco Magazine2019Top Doctor
    Marin Magazine2019Top Doctor
    Nephcure Kidney International2018Designated Nephrotic Syndrome Expert
    Haile T. Debas Academy of Medical Educators2016Excellence in Teaching Award

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    The Role of Nectin in Congenital Obstructive Nephropathy
    NIH K08DK068358Sep 1, 2004 - Nov 30, 2010
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Voices of Hope: Leveraging Think-Aloud Cognitive Interviews to Develop a Hope Assessment Tool for Young People Living with Chronic Health Conditions. Children (Basel). 2024 Nov 18; 11(11). von Scheven E, Braun M, Nahal B, Perito ER, Brakeman P, Soulsby WD, Quill L, Cuneo A, Franck LS. PMID: 39594971; PMCID: PMC11593005.
      View in: PubMed   Mentions:
    2. Healthcare Utilization Among Youth with Chronic Illness Receiving Care at a Large Urban Academic Healthcare System. Healthcare (Basel). 2024 Nov 14; 12(22). Soulsby WD, Franck LS, Perito E, Brakeman P, Cuneo A, Quill L, Boscardin J, von Scheven E. PMID: 39595475; PMCID: PMC11594139.
      View in: PubMed   Mentions:
    3. Feasibility of an implantable bioreactor for renal cell therapy using silicon nanopore membranes. Nat Commun. 2023 08 29; 14(1):4890. Kim EJ, Chen C, Gologorsky R, Santandreu A, Torres A, Wright N, Goodin MS, Moyer J, Chui BW, Blaha C, Brakeman P, Vartanian S, Tang Q, David Humes H, Fissell WH, Roy S. PMID: 37644033; PMCID: PMC10465514.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    4. Persistent Increase in Serum Ferritin Levels despite Converting to Permanent Vascular Access in Pediatric Hemodialysis Patients: Pediatric Nephrology Research Consortium Study. J Clin Med. 2023 Jun 25; 12(13). Onder AM, Ansari MAY, Deng F, Grinsell MM, Patterson L, Jetton J, Fathallah-Shaykh S, Ranch D, Aviles D, Copelovitch L, Ellis E, Chadha V, Elmaghrabi A, Lin JJ, Butani L, Haddad M, Marsenic O, Brakeman P, Quigley R, Shin HS, Garro R, Raina R, Langman CB. PMID: 37445286; PMCID: PMC10342380.
      View in: PubMed   Mentions:
    5. COVID-19 in pediatric kidney transplantation: a follow-up report of the Improving Renal Outcomes Collaborative. Pediatr Nephrol. 2023 02; 38(2):537-547. Varnell C, Harshman LA, Liu C, Smith L, Al-Akash S, Barletta GM, Brakeman P, Chaudhuri A, Fadakar P, Galea L, Garro R, Gluck C, Kershaw DB, Matossian D, Patel HP, Peterson C, Pruette C, Ranabothu S, Rodig N, Singer P, Sebestyen VanSickle J, Weng PL, Danziger-Isakov L, Seifert ME, Hooper DK. PMID: 35538239; PMCID: PMC9090538.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Urologic Considerations in Pediatric Chronic Kidney Disease. Adv Chronic Kidney Dis. 2022 05; 29(3):308-317. Lombel RM, Brakeman PR, Sack BS, Butani L. PMID: 36084977.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    7. Conversion to permanent vascular access is associated with improved markers of hemodialysis efficacy in children: Pediatric nephrology research consortium study. Clin Nephrol. 2021 Nov; 96(5):270-280. Onder AM, Flynn JT, Ansari MAY, Deng F, DeFreitas M, Katsoufis C, Grinsell MM, Patterson L, Jetton J, Fathallah-Shaykh S, Ranch D, Aviles D, Copelovitch L, Ellis E, Chadha V, Elmaghrabi A, Lin JJ, Butani L, Haddad M, Marsenic O, Brakeman P, Quigley R, Shin HS, Garro R, Raina R, Langman CB, Wood E, Pediatric Nephrology Research Consortium. PMID: 34190683.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. Association of Plasma Uremic Solute Levels with Residual Kidney Function in Children on Peritoneal Dialysis. Clin J Am Soc Nephrol. 2021 10; 16(10):1531-1538. Ganesan LL, O'Brien FJ, Sirich TL, Plummer NS, Sheth R, Fajardo C, Brakeman P, Sutherland SM, Meyer TW. PMID: 34233922; PMCID: PMC8499013.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    9. COVID-19 in pediatric kidney transplantation: The Improving Renal Outcomes Collaborative. Am J Transplant. 2021 08; 21(8):2740-2748. Varnell C, Harshman LA, Smith L, Liu C, Chen S, Al-Akash S, Barletta GM, Belsha C, Brakeman P, Chaudhuri A, Fadakar P, Garro R, Gluck C, Goebel J, Kershaw D, Matossian D, Nailescu C, Patel HP, Pruette C, Ranabothu S, Rodig N, Smith J, Sebestyen VanSickle J, Weng P, Danziger-Isakov L, Hooper DK, Seifert M. PMID: 33452854; PMCID: PMC8013281.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    10. Plasma pseudouridine levels reflect body size in children on hemodialysis. Pediatr Nephrol. 2020 02; 35(2):305-312. O'Brien FJ, Sirich TL, Taussig A, Fung E, Ganesan LL, Plummer NS, Brakeman P, Sutherland SM, Meyer TW. PMID: 31728748.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Predictors of time to first cannulation for arteriovenous fistula in pediatric hemodialysis patients: Midwest Pediatric Nephrology Consortium study. Pediatr Nephrol. 2020 02; 35(2):287-295. Onder AM, Flynn JT, Billings AA, Deng F, DeFreitas M, Katsoufis C, Grinsell MM, Patterson L, Jetton J, Fathallah-Shaykh S, Ranch D, Aviles D, Copelovitch L, Ellis E, Chadha V, Elmaghrabi A, Lin JJ, Butani L, Haddad M, Marsenic O, Brakeman P, Quigley R, Shin HS, Garro R, Liu H, Rahimikollu J, Raina R, Langman CB, Wood E, Midwest Pediatric Nephrology Consortium. PMID: 31696356.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    12. Simple Rules Determine Distinct Patterns of Branching Morphogenesis. Cell Syst. 2019 09 25; 9(3):221-227. Yu W, Marshall WF, Metzger RJ, Brakeman PR, Morsut L, Lim W, Mostov KE. PMID: 31557453; PMCID: PMC7577355.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    13. Correction to: Predictors of patency for arteriovenous fistulae and grafts in pediatric hemodialysis patients. Pediatr Nephrol. 2019 Aug; 34(8):1483-1484. Onder AM, Flynn JT, Billings AA, Deng F, DeFreitas M, Katsoufis C, Grinsell MM, Patterson LT, Jetton J, Fathallah-Shaykh S, Ranch D, Aviles D, Copelovitch L, Ellis E, Chadha V, Elmaghrabi A, Lin JJ, Butani L, Haddad M, Couloures OM, Brakeman P, Quigley R, Shin HS, Garro R, Liu H, Rahimikollu J, Raina R, Langman CB, Wood EG, Midwest Pediatric Nephrology Consortium. PMID: 30684015.
      View in: PubMed   Mentions:    Fields:    
    14. Application of physiological shear stress to renal tubular epithelial cells. Methods Cell Biol. 2019; 153:43-67. Ferrell N, Sandoval RM, Molitoris BA, Brakeman P, Roy S, Fissell WH. PMID: 31395384.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    15. Positive Cumulative Fluid Balance Is Associated With Mortality in Pediatric Acute Respiratory Distress Syndrome in the Setting of Acute Kidney Injury. Pediatr Crit Care Med. 2019 04; 20(4):323-331. Zinter MS, Spicer AC, Liu KD, Orwoll BE, Alkhouli MF, Brakeman PR, Calfee CS, Matthay MA, Sapru A. PMID: 30672838; PMCID: PMC6454886.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    16. Apical Shear Stress Enhanced Organic Cation Transport in Human OCT2/MATE1-Transfected Madin-Darby Canine Kidney Cells Involves Ciliary Sensing. J Pharmacol Exp Ther. 2019 06; 369(3):523-530. Jayagopal A, Brakeman PR, Soler P, Ferrell N, Fissell W, Kroetz DL, Roy S. PMID: 30910922; PMCID: PMC11047058.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    17. Outcome of participants with nephrotic syndrome in combined clinical trials of lupus nephritis. Lupus Sci Med. 2019; 6(1):e000308. Gomez Mendez LM, Cascino MD, Katsumoto TR, Brakeman P, Brunetta P, Jayne D, Dall'Era M, Rovin B, Garg J. PMID: 31080631; PMCID: PMC6485211.
      View in: PubMed   Mentions: 3     Fields:    
    18. Predictors of patency for arteriovenous fistulae and grafts in pediatric hemodialysis patients. Pediatr Nephrol. 2019 02; 34(2):329-339. Onder AM, Flynn JT, Billings AA, Deng F, DeFreitas M, Katsoufis C, Grinsell MM, Patterson LT, Jetton J, Fathallah-Shaykh S, Ranch D, Aviles D, Copelovitch L, Ellis E, Chanda V, Elmaghrabi A, Lin JJ, Butani L, Haddad M, Couloures OM, Brakeman P, Quigley R, Stella Shin H, Garro R, Liu H, Rahimikollu J, Raina R, Langman CB, Wood EG, Midwest Pediatric Nephrology Consortium. PMID: 30264215.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    19. Peripheral Blood B Cell Depletion after Rituximab and Complete Response in Lupus Nephritis. Clin J Am Soc Nephrol. 2018 10 08; 13(10):1502-1509. Gomez Mendez LM, Cascino MD, Garg J, Katsumoto TR, Brakeman P, Dall'Era M, Looney RJ, Rovin B, Dragone L, Brunetta P. PMID: 30089664; PMCID: PMC6218830.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    20. Renal function outcomes in pediatric patients with symptomatic reflux into the transplanted kidney treated with redo ureteroneocystostomy. J Pediatr Urol. 2018 06; 14(3):275.e1-275.e5. Wang MK, Chuang KW, Li Y, Gaither T, Brakeman P, Gonzalez L, Brennan J, Baskin LS. PMID: 29605164.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    21. Afadin orients cell division to position the tubule lumen in developing renal tubules. Development. 2017 10 01; 144(19):3511-3520. Gao L, Yang Z, Hiremath C, Zimmerman SE, Long B, Brakeman PR, Mostov KE, Bryant DM, Luby-Phelps K, Marciano DK. PMID: 28860115; PMCID: PMC5665479.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    22. Laser acupuncture reduces pain in pediatric kidney biopsies: a randomized controlled trial. Pain. 2017 01; 158(1):103-109. Oates A, Benedict KA, Sun K, Brakeman PR, Lim J, Kim C. PMID: 27749608; PMCID: PMC5234680.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    23. A modular microfluidic bioreactor with improved throughput for evaluation of polarized renal epithelial cells. Biomicrofluidics. 2016 Nov; 10(6):064106. Brakeman P, Miao S, Cheng J, Lee CZ, Roy S, Fissell WH, Ferrell N. PMID: 27917253; PMCID: PMC5116024.
      View in: PubMed   Mentions: 6  
    24. Preliminary Diffusive Clearance of Silicon Nanopore Membranes in a Parallel Plate Configuration for Renal Replacement Therapy. ASAIO J. 2016 Mar-Apr; 62(2):169-75. Kim S, Heller J, Iqbal Z, Kant R, Kim EJ, Durack J, Saeed M, Do L, Hetts S, Wilson M, Brakeman P, Fissell WH, Roy S. PMID: 26692401; PMCID: PMC4777646.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    25. Host cell polarity proteins participate in innate immunity to Pseudomonas aeruginosa infection. Cell Host Microbe. 2014 May 14; 15(5):636-43. Tran CS, Eran Y, Ruch TR, Bryant DM, Datta A, Brakeman P, Kierbel A, Wittmann T, Metzger RJ, Mostov KE, Engel JN. PMID: 24832456; PMCID: PMC4062193.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    26. Acute changes in blood pressure in patients with neuroblastoma treated with ¹³¹I-metaiodobenzylguanidine (MIBG). Pediatr Blood Cancer. 2013 Sep; 60(9):1424-30. Wong T, Matthay KK, Boscardin WJ, Hawkins RA, Brakeman PR, DuBois SG. PMID: 23613447.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCTClinical Trials
    27. De novo lumen formation and elongation in the developing nephron: a central role for afadin in apical polarity. Development. 2013 Apr; 140(8):1774-84. Yang Z, Zimmerman S, Brakeman PR, Beaudoin GM, Reichardt LF, Marciano DK. PMID: 23487309; PMCID: PMC3621492.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    28. Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cells. Nat Cell Biol. 2012 Aug; 14(8):838-49. Gálvez-Santisteban M, Rodriguez-Fraticelli AE, Bryant DM, Vergarajauregui S, Yasuda T, Bañón-Rodríguez I, Bernascone I, Datta A, Spivak N, Young K, Slim CL, Brakeman PR, Fukuda M, Mostov KE, Martín-Belmonte F. PMID: 22820376; PMCID: PMC3433678.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    29. Preso1 dynamically regulates group I metabotropic glutamate receptors. Nat Neurosci. 2012 Jun; 15(6):836-44. Hu JH, Yang L, Kammermeier PJ, Moore CG, Brakeman PR, Tu J, Yu S, Petralia RS, Li Z, Zhang PW, Park JM, Dong X, Xiao B, Worley PF. PMID: 22561452; PMCID: PMC3434267.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    30. p120 catenin is required for normal renal tubulogenesis and glomerulogenesis. Development. 2011 May; 138(10):2099-109. Marciano DK, Brakeman PR, Lee CZ, Spivak N, Eastburn DJ, Bryant DM, Beaudoin GM, Hofmann I, Mostov KE, Reichardt LF. PMID: 21521738; PMCID: PMC3082309.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    31. Nectin proteins are expressed at early stages of nephrogenesis and play a role in renal epithelial cell morphogenesis. Am J Physiol Renal Physiol. 2009 Mar; 296(3):F564-74. Brakeman PR, Liu KD, Shimizu K, Takai Y, Mostov KE. PMID: 19116242; PMCID: PMC2660185.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    32. Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity. EMBO Rep. 2008 Sep; 9(9):923-9. Yu W, Shewan AM, Brakeman P, Eastburn DJ, Datta A, Bryant DM, Fan QW, Weiss WA, Zegers MM, Mostov KE. PMID: 18660750; PMCID: PMC2529350.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    33. Renal repair and recovery. Crit Care Med. 2008 Apr; 36(4 Suppl):S187-92. Liu KD, Brakeman PR. PMID: 18382192.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimals
    34. Transient hyperglycemia affects the extent of ischemia-reperfusion-induced renal injury in rats. Anesthesiology. 2008 Mar; 108(3):402-14. Hirose R, Xu F, Dang K, Liu T, Behrends M, Brakeman PR, Wiener-Kronish J, Niemann CU. PMID: 18292678.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    35. Vesicoureteral reflux, reflux nephropathy, and end-stage renal disease. Adv Urol. 2008; 508949. Brakeman P. PMID: 18670633; PMCID: PMC2478704.
      View in: PubMed   Mentions: 12  
    36. Being overweight modifies the association between cardiovascular risk factors and microalbuminuria in adolescents. Pediatrics. 2008 Jan; 121(1):37-45. Nguyen S, McCulloch C, Brakeman P, Portale A, Hsu CY. PMID: 18166555; PMCID: PMC3722048.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    37. Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathway. Am J Physiol Renal Physiol. 2007 Nov; 293(5):F1633-40. Liu KD, Datta A, Yu W, Brakeman PR, Jou TS, Matthay MA, Mostov KE. PMID: 17804488.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    38. Polarity proteins PAR6 and aPKC regulate cell death through GSK-3beta in 3D epithelial morphogenesis. J Cell Sci. 2007 Jul 15; 120(Pt 14):2309-17. Kim M, Datta A, Brakeman P, Yu W, Mostov KE. PMID: 17606986.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    39. Formation of multicellular epithelial structures. Novartis Found Symp. 2005; 269:193-200; discussion 200-5, 223-30. Mostov K, Brakeman P, Datta A, Gassama A, Katz L, Kim M, Leroy P, Levin M, Liu K, Martin F, O'Brien LE, Verges M, Su T, Tang K, Tanimizu N, Yamaji T, Yu W. PMID: 16355541.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    40. The scaffold protein, Homer1b/c, regulates axon pathfinding in the central nervous system in vivo. Nat Neurosci. 2001 May; 4(5):499-506. Foa L, Rajan I, Haas K, Wu GY, Brakeman P, Worley P, Cline H. PMID: 11319558.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    41. Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron. 1999 Jul; 23(3):583-92. Tu JC, Xiao B, Naisbitt S, Yuan JP, Petralia RS, Brakeman P, Doan A, Aakalu VK, Lanahan AA, Sheng M, Worley PF. PMID: 10433269.
      View in: PubMed   Mentions: 437     Fields:    Translation:HumansAnimalsCells
    42. Homer: a protein that selectively binds metabotropic glutamate receptors. Nature. 1997 Mar 20; 386(6622):284-8. Brakeman PR, Lanahan AA, O'Brien R, Roche K, Barnes CA, Huganir RL, Worley PF. PMID: 9069287.
      View in: PubMed   Mentions: 371     Fields:    Translation:HumansAnimalsCells
    43. MR-based correction of brain PET measurements for heterogeneous gray matter radioactivity distribution. J Cereb Blood Flow Metab. 1996 Jul; 16(4):650-8. Meltzer CC, Zubieta JK, Links JM, Brakeman P, Stumpf MJ, Frost JJ. PMID: 8964805.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    44. Magnetohydrodynamics of blood flow. Magn Reson Med. 1990 Oct; 16(1):139-49. Keltner JR, Roos MS, Brakeman PR, Budinger TF. PMID: 2255234.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
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