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Paul Brakeman, MD, PhD

Title(s)Associate Professor, Pediatrics
SchoolSchool of Medicine
Address550 16th. Street
San Francisco CA 94158
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency School of Medicine
    John Hopkins UniversityM.D.1997School of Medicine
    Collapse Awards and Honors
    San Francisco Magazine2018Top Doctor
    Marin Magazine2018Top Doctor
    Nephcure Kidney International2018Designated Nephrotic Syndrome Expert
    Haile T. Debas Academy of Medical Educators2016Excellence in Teaching Award
    March of Dimes2010  - 2012Basil O’Connor Award

    Collapse Overview 
    Collapse Overview
    Dr. Brakeman is an Associate Professor at the the UCSF Benioff Children's Hospitals and the Medical Director of the Pediatric Kidney Transplant Program.

    The primary focus of his research is the development of medical devices for pediatric patients. Current projects include 1) the Neocare infant peritoneal dialysis machine (Funded by the UCSF Pediatric Device Consortium) 2) minimally invasive monitoring of serum analytes and 3) engineering of human renal epithelial cells for use in a bioartificial kidney in collaboration with Dr. Shuvo Roy’s lab.

    Collapse Research 
    Collapse Research Activities and Funding
    The Role of Nectin in Congenital Obstructive Nephropathy
    NIH/NIDDK K08DK068358Dec 18, 2009 - Nov 30, 2010
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Plasma pseudouridine levels reflect body size in children on hemodialysis. Pediatr Nephrol. 2020 02; 35(2):305-312. O'Brien FJ, Sirich TL, Taussig A, Fung E, Ganesan LL, Plummer NS, Brakeman P, Sutherland SM, Meyer TW. PMID: 31728748.
      View in: PubMed   Mentions:    Fields:    
    2. Predictors of time to first cannulation for arteriovenous fistula in pediatric hemodialysis patients: Midwest Pediatric Nephrology Consortium study. Pediatr Nephrol. 2020 02; 35(2):287-295. Onder AM, Flynn JT, Billings AA, Deng F, DeFreitas M, Katsoufis C, Grinsell MM, Patterson L, Jetton J, Fathallah-Shaykh S, Ranch D, Aviles D, Copelovitch L, Ellis E, Chadha V, Elmaghrabi A, Lin JJ, Butani L, Haddad M, Marsenic O, Brakeman P, Quigley R, Shin HS, Garro R, Liu H, Rahimikollu J, Raina R, Langman CB, Wood E. PMID: 31696356.
      View in: PubMed   Mentions:    Fields:    
    3. Simple Rules Determine Distinct Patterns of Branching Morphogenesis. Cell Syst. 2019 09 25; 9(3):221-227. Yu W, Marshall WF, Metzger RJ, Brakeman PR, Morsut L, Lim W, Mostov KE. PMID: 31557453.
      View in: PubMed   Mentions:    Fields:    
    4. Correction to: Predictors of patency for arteriovenous fistulae and grafts in pediatric hemodialysis patients. Pediatr Nephrol. 2019 Aug; 34(8):1483-1484. Onder AM, Flynn JT, Billings AA, Deng F, DeFreitas M, Katsoufis C, Grinsell MM, Patterson LT, Jetton J, Fathallah-Shaykh S, Ranch D, Aviles D, Copelovitch L, Ellis E, Chadha V, Elmaghrabi A, Lin JJ, Butani L, Haddad M, Couloures OM, Brakeman P, Quigley R, Shin HS, Garro R, Liu H, Rahimikollu J, Raina R, Langman CB, Wood EG. PMID: 30684015.
      View in: PubMed   Mentions:    Fields:    
    5. Application of physiological shear stress to renal tubular epithelial cells. Methods Cell Biol. 2019; 153:43-67. Ferrell N, Sandoval RM, Molitoris BA, Brakeman P, Roy S, Fissell WH. PMID: 31395384.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    6. Positive Cumulative Fluid Balance Is Associated With Mortality in Pediatric Acute Respiratory Distress Syndrome in the Setting of Acute Kidney Injury. Pediatr Crit Care Med. 2019 04; 20(4):323-331. Zinter MS, Spicer AC, Liu KD, Orwoll BE, Alkhouli MF, Brakeman PR, Calfee CS, Matthay MA, Sapru A. PMID: 30672838.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. Apical Shear Stress Enhanced Organic Cation Transport in Human OCT2/MATE1-Transfected Madin-Darby Canine Kidney Cells Involves Ciliary Sensing. J Pharmacol Exp Ther. 2019 06; 369(3):523-530. Jayagopal A, Brakeman PR, Soler P, Ferrell N, Fissell W, Kroetz DL, Roy S. PMID: 30910922.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    8. Outcome of participants with nephrotic syndrome in combined clinical trials of lupus nephritis. Lupus Sci Med. 2019; 6(1):e000308. Gomez Mendez LM, Cascino MD, Katsumoto TR, Brakeman P, Brunetta P, Jayne D, Dall'Era M, Rovin B, Garg J. PMID: 31080631.
      View in: PubMed   Mentions:
    9. Predictors of patency for arteriovenous fistulae and grafts in pediatric hemodialysis patients. Pediatr Nephrol. 2019 02; 34(2):329-339. Onder AM, Flynn JT, Billings AA, Deng F, DeFreitas M, Katsoufis C, Grinsell MM, Patterson LT, Jetton J, Fathallah-Shaykh S, Ranch D, Aviles D, Copelovitch L, Ellis E, Chanda V, Elmaghrabi A, Lin JJ, Butani L, Haddad M, Couloures OM, Brakeman P, Quigley R, Stella Shin H, Garro R, Liu H, Rahimikollu J, Raina R, Langman CB, Wood EG. PMID: 30264215.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Peripheral Blood B Cell Depletion after Rituximab and Complete Response in Lupus Nephritis. Clin J Am Soc Nephrol. 2018 10 08; 13(10):1502-1509. Gomez Mendez LM, Cascino MD, Garg J, Katsumoto TR, Brakeman P, Dall'Era M, Looney RJ, Rovin B, Dragone L, Brunetta P. PMID: 30089664.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    11. Renal function outcomes in pediatric patients with symptomatic reflux into the transplanted kidney treated with redo ureteroneocystostomy. J Pediatr Urol. 2018 06; 14(3):275.e1-275.e5. Wang MK, Chuang KW, Li Y, Gaither T, Brakeman P, Gonzalez L, Brennan J, Baskin LS. PMID: 29605164.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Afadin orients cell division to position the tubule lumen in developing renal tubules. Development. 2017 10 01; 144(19):3511-3520. Gao L, Yang Z, Hiremath C, Zimmerman SE, Long B, Brakeman PR, Mostov KE, Bryant DM, Luby-Phelps K, Marciano DK. PMID: 28860115.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    13. Laser acupuncture reduces pain in pediatric kidney biopsies: a randomized controlled trial. Pain. 2017 01; 158(1):103-109. Oates A, Benedict KA, Sun K, Brakeman PR, Lim J, Kim C. PMID: 27749608.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. A modular microfluidic bioreactor with improved throughput for evaluation of polarized renal epithelial cells. Biomicrofluidics. 2016 Nov; 10(6):064106. Brakeman P, Miao S, Cheng J, Lee CZ, Roy S, Fissell WH, Ferrell N. PMID: 27917253.
      View in: PubMed   Mentions:
    15. Preliminary Diffusive Clearance of Silicon Nanopore Membranes in a Parallel Plate Configuration for Renal Replacement Therapy. ASAIO J. 2016 Mar-Apr; 62(2):169-75. Kim S, Heller J, Iqbal Z, Kant R, Kim EJ, Durack J, Saeed M, Do L, Hetts S, Wilson M, Brakeman P, Fissell WH, Roy S. PMID: 26692401.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    16. Host cell polarity proteins participate in innate immunity to Pseudomonas aeruginosa infection. Cell Host Microbe. 2014 May 14; 15(5):636-43. Tran CS, Eran Y, Ruch TR, Bryant DM, Datta A, Brakeman P, Kierbel A, Wittmann T, Metzger RJ, Mostov KE, Engel JN. PMID: 24832456.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    17. Acute changes in blood pressure in patients with neuroblastoma treated with ¹³¹I-metaiodobenzylguanidine (MIBG). Pediatr Blood Cancer. 2013 Sep; 60(9):1424-30. Wong T, Matthay KK, Boscardin WJ, Hawkins RA, Brakeman PR, DuBois SG. PMID: 23613447.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    18. De novo lumen formation and elongation in the developing nephron: a central role for afadin in apical polarity. Development. 2013 Apr; 140(8):1774-84. Yang Z, Zimmerman S, Brakeman PR, Beaudoin GM, Reichardt LF, Marciano DK. PMID: 23487309.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    19. Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cells. Nat Cell Biol. 2012 Aug; 14(8):838-49. Gálvez-Santisteban M, Rodriguez-Fraticelli AE, Bryant DM, Vergarajauregui S, Yasuda T, Bañón-Rodríguez I, Bernascone I, Datta A, Spivak N, Young K, Slim CL, Brakeman PR, Fukuda M, Mostov KE, Martín-Belmonte F. PMID: 22820376.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    20. Preso1 dynamically regulates group I metabotropic glutamate receptors. Nat Neurosci. 2012 Jun; 15(6):836-44. Hu JH, Yang L, Kammermeier PJ, Moore CG, Brakeman PR, Tu J, Yu S, Petralia RS, Li Z, Zhang PW, Park JM, Dong X, Xiao B, Worley PF. PMID: 22561452.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    21. p120 catenin is required for normal renal tubulogenesis and glomerulogenesis. Development. 2011 May; 138(10):2099-109. Marciano DK, Brakeman PR, Lee CZ, Spivak N, Eastburn DJ, Bryant DM, Beaudoin GM, Hofmann I, Mostov KE, Reichardt LF. PMID: 21521738.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    22. Nectin proteins are expressed at early stages of nephrogenesis and play a role in renal epithelial cell morphogenesis. Am J Physiol Renal Physiol. 2009 Mar; 296(3):F564-74. Brakeman PR, Liu KD, Shimizu K, Takai Y, Mostov KE. PMID: 19116242.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    23. Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity. EMBO Rep. 2008 Sep; 9(9):923-9. Yu W, Shewan AM, Brakeman P, Eastburn DJ, Datta A, Bryant DM, Fan QW, Weiss WA, Zegers MM, Mostov KE. PMID: 18660750.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    24. Renal repair and recovery. Crit Care Med. 2008 Apr; 36(4 Suppl):S187-92. Liu KD, Brakeman PR. PMID: 18382192.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    25. Transient hyperglycemia affects the extent of ischemia-reperfusion-induced renal injury in rats. Anesthesiology. 2008 Mar; 108(3):402-14. Hirose R, Xu F, Dang K, Liu T, Behrends M, Brakeman PR, Wiener-Kronish J, Niemann CU. PMID: 18292678.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    26. Being overweight modifies the association between cardiovascular risk factors and microalbuminuria in adolescents. Pediatrics. 2008 Jan; 121(1):37-45. Nguyen S, McCulloch C, Brakeman P, Portale A, Hsu CY. PMID: 18166555.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    27. Vesicoureteral reflux, reflux nephropathy, and end-stage renal disease. Adv Urol. 2008; 508949. Brakeman P. PMID: 18670633.
      View in: PubMed   Mentions:
    28. Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathway. Am J Physiol Renal Physiol. 2007 Nov; 293(5):F1633-40. Liu KD, Datta A, Yu W, Brakeman PR, Jou TS, Matthay MA, Mostov KE. PMID: 17804488.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    29. Polarity proteins PAR6 and aPKC regulate cell death through GSK-3beta in 3D epithelial morphogenesis. J Cell Sci. 2007 Jul 15; 120(Pt 14):2309-17. Kim M, Datta A, Brakeman P, Yu W, Mostov KE. PMID: 17606986.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    30. Formation of multicellular epithelial structures. Novartis Found Symp. 2005; 269:193-200; discussion 200-5, 223-30. Mostov K, Brakeman P, Datta A, Gassama A, Katz L, Kim M, Leroy P, Levin M, Liu K, Martin F, O'Brien LE, Verges M, Su T, Tang K, Tanimizu N, Yamaji T, Yu W. PMID: 16355541.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    31. The scaffold protein, Homer1b/c, regulates axon pathfinding in the central nervous system in vivo. Nat Neurosci. 2001 May; 4(5):499-506. Foa L, Rajan I, Haas K, Wu GY, Brakeman P, Worley P, Cline H. PMID: 11319558.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    32. Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron. 1999 Jul; 23(3):583-92. Tu JC, Xiao B, Naisbitt S, Yuan JP, Petralia RS, Brakeman P, Doan A, Aakalu VK, Lanahan AA, Sheng M, Worley PF. PMID: 10433269.
      View in: PubMed   Mentions: 274     Fields:    Translation:HumansAnimalsCells
    33. Homer: a protein that selectively binds metabotropic glutamate receptors. Nature. 1997 Mar 20; 386(6622):284-8. Brakeman PR, Lanahan AA, O'Brien R, Roche K, Barnes CA, Huganir RL, Worley PF. PMID: 9069287.
      View in: PubMed   Mentions: 235     Fields:    Translation:HumansAnimalsCells
    34. MR-based correction of brain PET measurements for heterogeneous gray matter radioactivity distribution. J Cereb Blood Flow Metab. 1996 Jul; 16(4):650-8. Meltzer CC, Zubieta JK, Links JM, Brakeman P, Stumpf MJ, Frost JJ. PMID: 8964805.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    35. Magnetohydrodynamics of blood flow. Magn Reson Med. 1990 Oct; 16(1):139-49. Keltner JR, Roos MS, Brakeman PR, Budinger TF. PMID: 2255234.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
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