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Nirav Bhakta, MD

Title(s)Associate Professor, Medicine
SchoolSchool of Medicine
Address505 Parnassus Avenue
San Francisco CA 94117
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral fellowship2013Asthma Genomics
    University of California, San FranciscoFellowship2011Pulmonary and Critical Care Medicine
    University of California, San FranciscoResidency 2008School of Medicine - Internal Medicine
    Stanford UniversityM.D.2006School of Medicine
    Stanford UniversityPh.D.2006School of Medicine, Molecular and Cellular Physiology
    Massachusetts Institute of TechnologyElectrical Engineering and Electrical Science1998Electrical Engineering
    University of California, San Francisco, CA2018Diversity, Equity, and Inclusion Champion Training
    Collapse Awards and Honors
    UCSF2018Michael S. Stulbarg Outstanding Teaching Award
    University of Vermont, Department of Pathology2017Invited Grand Rounds Speaker
    UCSF2016Nina Ireland Program for Lung Health
    UCSF2011  - 2012Podell Hewett Fellowship in Translational Airway Research

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Translational research on the role of IL-17 cytokines in severe asthma
    NIH/NHLBI K23HL116657May 1, 2014 - Apr 30, 2019
    Role: Principal Investigator
    Using signatures of T-helper cell inflammation to phenotype human asthma
    NIH/NHLBI F32HL110720Jan 1, 2012 - Dec 31, 2012
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Restoring Pulmonary and Sleep Services as the COVID-19 Pandemic Lessens: From an Association of Pulmonary, Critical Care, and Sleep Division Directors and American Thoracic Society-coordinated Task Force. Ann Am Thorac Soc. 2020 Jul 14. Wilson KC, Kaminsky DA, Michaud G, Sharma S, Nici L, Folz RJ, Barjaktarevic I, Bhakta NR, Cheng G, Chupp GL, Cole A, Dixon AE, Finigan JH, Graham B, Hallstrand TS, Haynes J, Hankinson J, MacIntyre N, Mandel J, McCarthy K, McCormack M, Patil SP, Rosenfeld M, Senitko M, Sethi S, Swenson ER, Stanojevic S, Teodorescu M, Weiner DJ, Wiener RS, Powell CA. PMID: 32663071.
      View in: PubMed   Mentions:    Fields:    
    2. Deep neural network analyses of spirometry for structural phenotyping of chronic obstructive pulmonary disease. JCI Insight. 2020 Jun 18. Bodduluri S, Nakhmani A, Reinhardt JM, Wilson CG, McDonald MN, Rudraraju R, Jaeger BC, Bhakta NR, Castaldi PJ, Sciurba FC, Zhang C, Bangalore PV, Bhatt SP. PMID: 32554922.
      View in: PubMed   Mentions:    Fields:    
    3. Distinct associations of sputum and oral microbiota with atopic, immunologic, and clinical features in mild asthma. J Allergy Clin Immunol. 2020 Apr 13. Durack J, Christian LS, Nariya S, Gonzalez J, Bhakta NR, Ansel KM, Beigelman A, Castro M, Dyer AM, Israel E, Kraft M, Martin RJ, Mauger DT, Peters SP, Rosenberg SR, Sorkness CA, Wechsler ME, Wenzel SE, White SR, Lynch SV, Boushey HA, Huang YJ. PMID: 32298699.
      View in: PubMed   Mentions:    Fields:    
    4. Air Trapping Correlates with Increased Frequency of Albuterol Use and Severity of Wheeze in Persistent Asthma. Respir Care. 2020 Feb 04. Vempilly JJ, Abejie BA, Rashidian A, Jain VV, Bhakta N. PMID: 32019852.
      View in: PubMed   Mentions:    Fields:    
    5. Clinical Significance of Bronchodilator Responsiveness Evaluated by Forced Vital Capacity in COPD: SPIROMICS Cohort Analysis. Int J Chron Obstruct Pulmon Dis. 2019; 14:2927-2938. Barjaktarevic IZ, Buhr RG, Wang X, Hu S, Couper D, Anderson W, Kanner RE, Paine Iii R, Bhatt SP, Bhakta NR, Arjomandi M, Kaner RJ, Pirozzi CS, Curtis JL, O'Neal WK, Woodruff PG, Han MK, Martinez FJ, Hansel N, Wells JM, Ortega VE, Hoffman EA, Doerschuk CM, Kim V, Dransfield MT, Drummond MB, Bowler R, Criner G, Christenson SA, Ronish B, Peters SP, Krishnan JA, Tashkin DP, Cooper CB. PMID: 31908441.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. The Peak Index: Spirometry Metric for Airflow Obstruction Severity and Heterogeneity. Ann Am Thorac Soc. 2019 08; 16(8):982-989. Bhatt SP, Bodduluri S, Raghav V, Bhakta NR, Wilson CG, Kim YI, Eberlein M, Sciurba FC, Han MK, Dransfield MT, Nakhmani A. PMID: 30865842.
      View in: PubMed   Mentions:    Fields:    
    7. Conjugated bile acids attenuate allergen-induced airway inflammation and hyperresponsiveness by inhibiting UPR transducers. JCI Insight. 2019 05 02; 4(9). Nakada EM, Bhakta NR, Korwin-Mihavics BR, Kumar A, Chamberlain N, Bruno SR, Chapman DG, Hoffman SM, Daphtary N, Aliyeva M, Irvin CG, Dixon AE, Woodruff PG, Amin S, Poynter ME, Desai DH, Anathy V. PMID: 31045581.
      View in: PubMed   Mentions: 3     Fields:    
    8. Unique Circulating MicroRNA Profiles in HIV Infection. J Acquir Immune Defic Syndr. 2018 12 15; 79(5):644-650. Narla V, Bhakta N, Freedman JE, Tanriverdi K, Maka K, Deeks SG, Ganz P, Hsue P. PMID: 30204717.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    9. New Spirometry Indices for Detecting Mild Airflow Obstruction. Sci Rep. 2018 11 30; 8(1):17484. Bhatt SP, Bhakta NR, Wilson CG, Cooper CB, Barjaktarevic I, Bodduluri S, Kim YI, Eberlein M, Woodruff PG, Sciurba FC, Castaldi PJ, Han MK, Dransfield MT, Nakhmani A. PMID: 30504791.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup. J Clin Invest. 2019 01 02; 129(1):169-181. Christenson SA, van den Berge M, Faiz A, Inkamp K, Bhakta N, Bonser LR, Zlock LT, Barjaktarevic IZ, Barr RG, Bleecker ER, Boucher RC, Bowler RP, Comellas AP, Curtis JL, Han MK, Hansel NN, Hiemstra PS, Kaner RJ, Krishnanm JA, Martinez FJ, O'Neal WK, Paine R, Timens W, Wells JM, Spira A, Erle DJ, Woodruff PG. PMID: 30383540.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    11. Large Differences in Small RNA Composition Between Human Biofluids. Cell Rep. 2018 10 30; 25(5):1346-1358. Godoy PM, Bhakta NR, Barczak AJ, Cakmak H, Fisher S, MacKenzie TC, Patel T, Price RW, Smith JF, Woodruff PG, Erle DJ. PMID: 30380423.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    12. IFN-stimulated Gene Expression, Type 2 Inflammation, and Endoplasmic Reticulum Stress in Asthma. Am J Respir Crit Care Med. 2018 02 01; 197(3):313-324. Bhakta NR, Christenson SA, Nerella S, Solberg OD, Nguyen CP, Choy DF, Jung KL, Garudadri S, Bonser LR, Pollack JL, Zlock LT, Erle DJ, Langelier C, Derisi JL, Arron JR, Fahy JV, Woodruff PG. PMID: 29064281.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    13. Corticosteroid and long-acting ß-agonist therapy reduces epithelial goblet cell metaplasia. Clin Exp Allergy. 2017 Dec; 47(12):1534-1545. Lachowicz-Scroggins ME, Finkbeiner WE, Gordon ED, Yuan S, Zlock L, Bhakta NR, Woodruff PG, Fahy JV, Boushey HA. PMID: 28833774.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    14. More Than Meets the Eye: Cigarette Smoke Induces Genomic Changes in the Small Airway Epithelium Independent of Histologic Changes. Am J Respir Crit Care Med. 2017 08 01; 196(3):260-262. Bartel S, Bhakta N, Christenson S. PMID: 28762786.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    15. Effects of Age and Disease Severity on Systemic Corticosteroid Responses in Asthma. Am J Respir Crit Care Med. 2017 06 01; 195(11):1439-1448. Phipatanakul W, Mauger DT, Sorkness RL, Gaffin JM, Holguin F, Woodruff PG, Ly NP, Bacharier LB, Bhakta NR, Moore WC, Bleecker ER, Hastie AT, Meyers DA, Castro M, Fahy JV, Fitzpatrick AM, Gaston BM, Jarjour NN, Levy BD, Peters SP, Teague WG, Fajt M, Wenzel SE, Erzurum SC, Israel E. PMID: 27967215.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    16. By Expanding the Color Palette, CO-Oximetry Overcomes Some, but Not All, of the Uncommon Limitations of Pulse Oximetry. Ann Am Thorac Soc. 2017 04; 14(4):609. Bhakta NR. PMID: 28362526.
      View in: PubMed   Mentions:    Fields:    
    17. Natural killer cell-mediated inflammation resolution is disabled in severe asthma. Sci Immunol. 2017 Mar 10; 2(9). Duvall MG, Barnig C, Cernadas M, Ricklefs I, Krishnamoorthy N, Grossman NL, Bhakta NR, Fahy JV, Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Israel E, Levy BD. PMID: 28783702.
      View in: PubMed   Mentions: 9     Fields:    
    18. Insights from Recognition of a Contradiction in the Equations that Define the Diffusing Capacity of the Lung for Carbon Monoxide. Ann Am Thorac Soc. 2017 03; 14(3):473-474. Bhakta NR. PMID: 28248579.
      View in: PubMed   Mentions:    Fields:    
    19. Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations. Am J Respir Crit Care Med. 2017 02 01; 195(3):302-313. Denlinger LC, Phillips BR, Ramratnam S, Ross K, Bhakta NR, Cardet JC, Castro M, Peters SP, Phipatanakul W, Aujla S, Bacharier LB, Bleecker ER, Comhair SA, Coverstone A, DeBoer M, Erzurum SC, Fain SB, Fajt M, Fitzpatrick AM, Gaffin J, Gaston B, Hastie AT, Hawkins GA, Holguin F, Irani AM, Israel E, Levy BD, Ly N, Meyers DA, Moore WC, Myers R, Opina MT, Peters MC, Schiebler ML, Sorkness RL, Teague WG, Wenzel SE, Woodruff PG, Mauger DT, Fahy JV, Jarjour NN. PMID: 27556234.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCellsCTClinical Trials
    20. Grease fires turn up the heat in autoimmune disease. Sci Transl Med. 2017 01 25; 9(374). Bhakta NR. PMID: 28123070.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    21. Pitfalls of probiotics. Sci Transl Med. 2016 12 07; 8(368):368ec194. Bhakta NR. PMID: 27928020.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. Acute exacerbations of asthma. Pulmonary Emergencies. 2016 Dec 1; 66-85. Nirav R. Bhakta, Stephen C. Lazarus. .
      View in: Publisher Site   Mentions:
    23. Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment. J Allergy Clin Immunol. 2017 Jul; 140(1):63-75. Durack J, Lynch SV, Nariya S, Bhakta NR, Beigelman A, Castro M, Dyer AM, Israel E, Kraft M, Martin RJ, Mauger DT, Rosenberg SR, Sharp-King T, White SR, Woodruff PG, Avila PC, Denlinger LC, Holguin F, Lazarus SC, Lugogo N, Moore WC, Peters SP, Que L, Smith LJ, Sorkness CA, Wechsler ME, Wenzel SE, Boushey HA, Huang YJ. PMID: 27838347.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    24. Pairing the right ingredients for the perfect drug cocktail. Science Translational Medicine. 2016 Sep 14; 8(356):356ec146-356ec146. Nirav R. Bhakta. .
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    25. A shocking way to suppress inflammation. Science Translational Medicine. 2016 Aug 3; 8(350):350ec122-350ec122. Nirav R. Bhakta. .
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    26. Fire extinguishers turn down the gain on pain. Science Translational Medicine. 2016 Jun 22; 8(344):344ec98-344ec98. Nirav R. Bhakta. .
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    27. IFN-?-Producing T-Helper 17.1 Cells Are Increased in Sarcoidosis and Are More Prevalent than T-Helper Type 1 Cells. Am J Respir Crit Care Med. 2016 06 01; 193(11):1281-91. Ramstein J, Broos CE, Simpson LJ, Ansel KM, Sun SA, Ho ME, Woodruff PG, Bhakta NR, Christian L, Nguyen CP, Antalek BJ, Benn BS, Hendriks RW, van den Blink B, Kool M, Koth LL. PMID: 26649486.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    28. Safely accelerating past stop signs. Science Translational Medicine. 2016 May 11; 8(338):338ec74-338ec74. Nirav R. Bhakta. .
      View in: Publisher Site   Mentions:
    29. Scientists flip-flop: Vitamin C suppresses immunity. Science Translational Medicine. 2016 Mar 30; 8(332):332ec51-332ec51. Nirav R. Bhakta. .
      View in: Publisher Site   Mentions:
    30. 41 Asthma Pathogenesis and Phenotypes. Murray and Nadel\u0027s Textbook of Respiratory Medicine. 2016 Jan 1; (N Engl J Med365122011):713-730.e7. Prescott G. Woodruff, Nirav R. Bhakta, John V. Fahy. .
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    31. Protein disulfide isomerase-endoplasmic reticulum resident protein 57 regulates allergen-induced airways inflammation, fibrosis, and hyperresponsiveness. J Allergy Clin Immunol. 2016 Mar; 137(3):822-32.e7. Hoffman SM, Chapman DG, Lahue KG, Cahoon JM, Rattu GK, Daphtary N, Aliyeva M, Fortner KA, Erzurum SC, Comhair SA, Woodruff PG, Bhakta N, Dixon AE, Irvin CG, Janssen-Heininger YM, Poynter ME, Anathy V. PMID: 26435004.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    32. Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells. Nature. 2015 Oct 01; 526(7571):131-5. Lawson DA, Bhakta NR, Kessenbrock K, Prummel KD, Yu Y, Takai K, Zhou A, Eyob H, Balakrishnan S, Wang CY, Yaswen P, Goga A, Werb Z. PMID: 26416748.
      View in: PubMed   Mentions: 160     Fields:    Translation:HumansAnimalsCells
    33. UNIQUE CIRCULATING MICRORNA PROFILES AND ENDOTHELIAL FUNCTION IN HIV INFECTION. Journal of the American College of Cardiology. 2015 Mar 1; 65(10):a1478. Annie V. Narla, Nirav Bhakta, Jane Freedman, Kahraman Tanriverdi, Kristinalisa Maka, Steven Deeks, Peter Ganz, Priscilla Hsue. .
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    34. A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production. Nat Immunol. 2014 Dec; 15(12):1162-70. Simpson LJ, Patel S, Bhakta NR, Choy DF, Brightbill HD, Ren X, Wang Y, Pua HH, Baumjohann D, Montoya MM, Panduro M, Remedios KA, Huang X, Fahy JV, Arron JR, Woodruff PG, Ansel KM. PMID: 25362490.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    35. IL-17 and "TH2-high" asthma: Adding fuel to the fire? J Allergy Clin Immunol. 2014 Nov; 134(5):1187-8. Bhakta NR, Erle DJ. PMID: 25174869.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    36. Longitudinal analysis of sarcoidosis blood transcriptomic signatures and disease outcomes. Eur Respir J. 2014 Oct; 44(4):985-93. Su R, Li MM, Bhakta NR, Solberg OD, Darnell EP, Ramstein J, Garudadri S, Ho M, Woodruff PG, Koth LL. PMID: 25142485.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    37. Accumulation of BDCA1? dendritic cells in interstitial fibrotic lung diseases and Th2-high asthma. PLoS One. 2014; 9(6):e99084. Greer AM, Matthay MA, Kukreja J, Bhakta NR, Nguyen CP, Wolters PJ, Woodruff PG, Fahy JV, Shin JS. PMID: 24915147.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    38. Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma. J Allergy Clin Immunol. 2014 Feb; 133(2):388-94. Peters MC, Mekonnen ZK, Yuan S, Bhakta NR, Woodruff PG, Fahy JV. PMID: 24075231.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    39. A qPCR-based metric of Th2 airway inflammation in asthma. Clin Transl Allergy. 2013 Jul 17; 3(1):24. Bhakta NR, Solberg OD, Nguyen CP, Nguyen CN, Arron JR, Fahy JV, Woodruff PG. PMID: 23866775.
      View in: PubMed   Mentions:
    40. Altered microRNA profiles in bronchoalveolar lavage fluid exosomes in asthmatic patients. J Allergy Clin Immunol. 2013 Mar; 131(3):894-903. Levänen B, Bhakta NR, Torregrosa Paredes P, Barbeau R, Hiltbrunner S, Pollack JL, Sköld CM, Svartengren M, Grunewald J, Gabrielsson S, Eklund A, Larsson BM, Woodruff PG, Erle DJ, Wheelock ÅM. PMID: 23333113.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCellsPHPublic Health
    41. Airway epithelial miRNA expression is altered in asthma. Am J Respir Crit Care Med. 2012 Nov 15; 186(10):965-74. Solberg OD, Ostrin EJ, Love MI, Peng JC, Bhakta NR, Hou L, Nguyen C, Solon M, Nguyen C, Barczak AJ, Zlock LT, Blagev DP, Finkbeiner WE, Ansel KM, Arron JR, Erle DJ, Woodruff PG. PMID: 22955319.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansCellsCTClinical Trials
    42. Sarcoidosis blood transcriptome reflects lung inflammation and overlaps with tuberculosis. Am J Respir Crit Care Med. 2011 Nov 15; 184(10):1153-63. Koth LL, Solberg OD, Peng JC, Bhakta NR, Nguyen CP, Woodruff PG. PMID: 21852540.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    43. Human asthma phenotypes: from the clinic, to cytokines, and back again. Immunol Rev. 2011 Jul; 242(1):220-32. Bhakta NR, Woodruff PG. PMID: 21682748.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    44. Real-time measurement of signaling and motility during T cell development in the thymus. Semin Immunol. 2005 Dec; 17(6):411-20. Bhakta NR, Lewis RS. PMID: 16256363.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    45. Calcium oscillations regulate thymocyte motility during positive selection in the three-dimensional thymic environment. Nat Immunol. 2005 Feb; 6(2):143-51. Bhakta NR, Oh DY, Lewis RS. PMID: 15654342.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    46. Dynamics of thymocyte-stromal cell interactions visualized by two-photon microscopy. Science. 2002 Jun 07; 296(5574):1876-80. Bousso P, Bhakta NR, Lewis RS, Robey E. PMID: 12052962.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    47. The effect of dynamic compression on the response of articular cartilage to insulin-like growth factor-I. J Orthop Res. 2001 Jan; 19(1):11-7. Bonassar LJ, Grodzinsky AJ, Frank EH, Davila SG, Bhaktav NR, Trippel SB. PMID: 11332605.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
    48. The insulin-like growth factors (IGFs) I and II bind to articular cartilage via the IGF-binding proteins. J Biol Chem. 2000 Feb 25; 275(8):5860-6. Bhakta NR, Garcia AM, Frank EH, Grodzinsky AJ, Morales TI. PMID: 10681577.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
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