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Nirav Bhakta, MD

TitleAssistant Professor
SchoolUCSF School of Medicine
DepartmentMedicine
Address513 Parnassus Avenue
San Francisco CA 94117
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral fellowship2013Asthma Genomics
    University of California, San FranciscoFellowship2011Pulmonary and Critical Care Medicine
    University of California, San FranciscoResidency 2008School of Medicine - Internal Medicine
    Stanford UniversityM.D.2006School of Medicine
    Stanford UniversityPh.D.2006School of Medicine, Molecular and Cellular Physiology
    Massachusetts Institute of TechnologyElectrical Engineering and Electrical Science1998Electrical Engineering
    Collapse Awards and Honors
    University of Vermont, Department of Pathology2017Invited Grand Rounds Speaker
    UCSF2016Nina Ireland Program for Lung Health
    UCSF2011  - 2012Podell Hewett Fellowship in Translational Airway Research

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Translational research on the role of IL-17 cytokines in severe asthma
    NIH/NHLBI K23HL116657May 1, 2014 - Apr 30, 2019
    Role: Principal Investigator
    Using signatures of T-helper cell inflammation to phenotype human asthma
    NIH/NHLBI F32HL110720Jan 1, 2012 - Dec 31, 2012
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Bhakta N, Christenson SA, Nerella S, Solberg OD, Nguyen CP, Choy DF, Jung KL, Garudadri S, Bonser LR, Pollack JL, Zlock LT, Erle DJ, Langelier C, Derisi JL, Arron JR, Fahy JV, Woodruff PG. Interferon-stimulated Gene Expression, Type-2 Inflammation and Endoplasmic Reticulum Stress in Asthma. Am J Respir Crit Care Med. 2017 Oct 24. PMID: 29064281.
      View in: PubMed
    2. Lachowicz-Scroggins ME, Finkbeiner WE, Gordon ED, Yuan S, Zlock L, Bhakta N, Woodruff PG, Fahy JV, Boushey HA. Corticosteroid and long-acting ß-agonist therapy reduces epithelial goblet cell metaplasia. Clin Exp Allergy. 2017 Aug 22. PMID: 28833774.
      View in: PubMed
    3. Bartel S, Bhakta N, Christenson S. More Than Meets the Eye: Cigarette Smoke Induces Genomic Changes in the Small Airway Epithelium Independent of Histologic Changes. Am J Respir Crit Care Med. 2017 Aug 01; 196(3):260-262. PMID: 28762786.
      View in: PubMed
    4. Phipatanakul W, Mauger DT, Sorkness RL, Gaffin JM, Holguin F, Woodruff PG, Ly NP, Bacharier LB, Bhakta N, Moore WC, Bleecker ER, Hastie AT, Meyers DA, Castro M, Fahy JV, Fitzpatrick AM, Gaston BM, Jarjour NN, Levy BD, Peters SP, Teague WG, Fajt M, Wenzel SE, Erzurum SC, Israel E. Effects of Age and Disease Severity on Systemic Corticosteroid Responses in Asthma. Am J Respir Crit Care Med. 2017 Jun 01; 195(11):1439-1448. PMID: 27967215.
      View in: PubMed
    5. Bhakta N. By Expanding the Color Palette, CO-Oximetry Overcomes Some, but Not All, of the Uncommon Limitations of Pulse Oximetry. Ann Am Thorac Soc. 2017 Apr; 14(4):609. PMID: 28362526.
      View in: PubMed
    6. Duvall MG, Barnig C, Cernadas M, Ricklefs I, Krishnamoorthy N, Grossman NL, Bhakta N, Fahy JV, Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Israel E, Levy BD. Natural killer cell-mediated inflammation resolution is disabled in severe asthma. Sci Immunol. 2017 Mar 10; 2(9). PMID: 28783702.
      View in: PubMed
    7. Bhakta N. Insights from Recognition of a Contradiction in the Equations that Define the Diffusing Capacity of the Lung for Carbon Monoxide. Ann Am Thorac Soc. 2017 Mar; 14(3):473-474. PMID: 28248579.
      View in: PubMed
    8. Denlinger LC, Phillips BR, Ramratnam S, Ross K, Bhakta N, Cardet JC, Castro M, Peters SP, Phipatanakul W, Aujla S, Bacharier LB, Bleecker ER, Comhair SA, Coverstone A, DeBoer M, Erzurum SC, Fain SB, Fajt M, Fitzpatrick AM, Gaffin J, Gaston B, Hastie AT, Hawkins GA, Holguin F, Irani AM, Israel E, Levy BD, Ly N, Meyers DA, Moore WC, Myers R, Opina MT, Peters MC, Schiebler ML, Sorkness RL, Teague WG, Wenzel SE, Woodruff PG, Mauger DT, Fahy JV, Jarjour NN, et al. Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations. Am J Respir Crit Care Med. 2017 Feb 01; 195(3):302-313. PMID: 27556234.
      View in: PubMed
    9. Bhakta N. Grease fires turn up the heat in autoimmune disease. Sci Transl Med. 2017 Jan 25; 9(374). PMID: 28123070.
      View in: PubMed
    10. Bhakta N. Pitfalls of probiotics. Sci Transl Med. 2016 Dec 07; 8(368):368ec194. PMID: 27928020.
      View in: PubMed
    11. Durack J, Lynch SV, Nariya S, Bhakta N, Beigelman A, Castro M, Dyer AM, Israel E, Kraft M, Martin RJ, Mauger DT, Rosenberg SR, Sharp-King T, White SR, Woodruff PG, Avila PC, Denlinger LC, Holguin F, Lazarus SC, Lugogo N, Moore WC, Peters SP, Que L, Smith LJ, Sorkness CA, Wechsler M, Wenzel SE, Boushey HA, Huang YJ. Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment. J Allergy Clin Immunol. 2017 Jul; 140(1):63-75. PMID: 27838347.
      View in: PubMed
    12. Ramstein J, Broos CE, Simpson LJ, Ansel KM, Sun SA, Ho ME, Woodruff PG, Bhakta N, Christian L, Nguyen CP, Antalek BJ, Benn BS, Hendriks RW, van den Blink B, Kool M, Koth LL. IFN-?-Producing T-Helper 17.1 Cells Are Increased in Sarcoidosis and Are More Prevalent than T-Helper Type 1 Cells. Am J Respir Crit Care Med. 2016 Jun 01; 193(11):1281-91. PMID: 26649486; PMCID: PMC4910899 [Available on 06/01/17].
    13. Hoffman SM, Chapman DG, Lahue KG, Cahoon JM, Rattu GK, Daphtary N, Aliyeva M, Fortner KA, Erzurum SC, Comhair SA, Woodruff PG, Bhakta N, Dixon AE, Irvin CG, Janssen-Heininger YM, Poynter ME, Anathy V. Protein disulfide isomerase-endoplasmic reticulum resident protein 57 regulates allergen-induced airways inflammation, fibrosis, and hyperresponsiveness. J Allergy Clin Immunol. 2016 Mar; 137(3):822-32.e7. PMID: 26435004; PMCID: PMC4597791 [Available on 03/01/17].
    14. Lawson DA, Bhakta N, Kessenbrock K, Prummel KD, Yu Y, Takai K, Zhou A, Eyob H, Balakrishnan S, Wang CY, Yaswen P, Goga A, Werb Z. Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells. Nature. 2015 Oct 01; 526(7571):131-5. PMID: 26416748; PMCID: PMC4648562.
    15. Simpson LJ, Patel S, Bhakta N, Choy DF, Brightbill HD, Ren X, Wang Y, Pua HH, Baumjohann D, Montoya MM, Panduro M, Remedios KA, Huang X, Fahy JV, Arron JR, Woodruff PG, Ansel KM. A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production. Nat Immunol. 2014 Dec; 15(12):1162-70. PMID: 25362490; PMCID: PMC4233009.
    16. Bhakta N, Erle DJ. IL-17 and "TH2-high" asthma: Adding fuel to the fire? J Allergy Clin Immunol. 2014 Nov; 134(5):1187-8. PMID: 25174869.
      View in: PubMed
    17. Su R, Li MM, Bhakta N, Solberg OD, Darnell EP, Ramstein J, Garudadri S, Ho M, Woodruff PG, Koth LL. Longitudinal analysis of sarcoidosis blood transcriptomic signatures and disease outcomes. Eur Respir J. 2014 Oct; 44(4):985-93. PMID: 25142485.
      View in: PubMed
    18. Greer AM, Matthay MA, Kukreja J, Bhakta N, Nguyen CP, Wolters PJ, Woodruff PG, Fahy JV, Shin JS. Accumulation of BDCA1? dendritic cells in interstitial fibrotic lung diseases and Th2-high asthma. PLoS One. 2014; 9(6):e99084. PMID: 24915147; PMCID: PMC4051692.
    19. Peters MC, Mekonnen ZK, Yuan S, Bhakta N, Woodruff PG, Fahy JV. Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma. J Allergy Clin Immunol. 2014 Feb; 133(2):388-94. PMID: 24075231; PMCID: PMC3981552.
    20. Bhakta N, Solberg OD, Nguyen CP, Nguyen CN, Arron JR, Fahy JV, Woodruff PG. A qPCR-based metric of Th2 airway inflammation in asthma. Clin Transl Allergy. 2013 Jul 17; 3(1):24. PMID: 23866775; PMCID: PMC3724712.
    21. Levänen B, Bhakta N, Torregrosa Paredes P, Barbeau R, Hiltbrunner S, Pollack JL, Sköld CM, Svartengren M, Grunewald J, Gabrielsson S, Eklund A, Larsson BM, Woodruff PG, Erle DJ, Wheelock ÅM. Altered microRNA profiles in bronchoalveolar lavage fluid exosomes in asthmatic patients. J Allergy Clin Immunol. 2013 Mar; 131(3):894-903. PMID: 23333113; PMCID: PMC4013392.
    22. Solberg OD, Ostrin EJ, Love MI, Peng JC, Bhakta N, Hou L, Nguyen C, Solon M, Nguyen C, Barczak AJ, Zlock LT, Blagev DP, Finkbeiner WE, Ansel KM, Arron JR, Erle DJ, Woodruff PG. Airway epithelial miRNA expression is altered in asthma. Am J Respir Crit Care Med. 2012 Nov 15; 186(10):965-74. PMID: 22955319; PMCID: PMC3530212.
    23. Koth LL, Solberg OD, Peng JC, Bhakta N, Nguyen CP, Woodruff PG. Sarcoidosis blood transcriptome reflects lung inflammation and overlaps with tuberculosis. Am J Respir Crit Care Med. 2011 Nov 15; 184(10):1153-63. PMID: 21852540; PMCID: PMC3262024.
    24. Bhakta N, Woodruff PG. Human asthma phenotypes: from the clinic, to cytokines, and back again. Immunol Rev. 2011 Jul; 242(1):220-32. PMID: 21682748; PMCID: PMC3391010.
    25. Bhakta N, Lewis RS. Real-time measurement of signaling and motility during T cell development in the thymus. Semin Immunol. 2005 Dec; 17(6):411-20. PMID: 16256363.
      View in: PubMed
    26. Bhakta N, Oh DY, Lewis RS. Calcium oscillations regulate thymocyte motility during positive selection in the three-dimensional thymic environment. Nat Immunol. 2005 Feb; 6(2):143-51. PMID: 15654342.
      View in: PubMed
    27. Bousso P, Bhakta N, Lewis RS, Robey E. Dynamics of thymocyte-stromal cell interactions visualized by two-photon microscopy. Science. 2002 Jun 07; 296(5574):1876-80. PMID: 12052962.
      View in: PubMed
    28. Bonassar LJ, Grodzinsky AJ, Frank EH, Davila SG, Bhaktav NR, Trippel SB. The effect of dynamic compression on the response of articular cartilage to insulin-like growth factor-I. J Orthop Res. 2001 Jan; 19(1):11-7. PMID: 11332605.
      View in: PubMed
    29. Bhakta N, Garcia AM, Frank EH, Grodzinsky AJ, Morales TI. The insulin-like growth factors (IGFs) I and II bind to articular cartilage via the IGF-binding proteins. J Biol Chem. 2000 Feb 25; 275(8):5860-6. PMID: 10681577.
      View in: PubMed
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