Elvira Mennillo, PhD

Title(s)Specialist, Medicine
SchoolSchool of Medicine
Address513 Parnassus Avenue, MSB, #1071A
San Francisco CA 94143
Phone415-502-4444
ORCID ORCID Icon0000-0002-3210-1004 Additional info
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    As a Specialist in the Medicine department at UCSF, my career has been focused on conducting impactful research in the field of medicine. My current studies involve detailed multi-omics analysis of intestinal tissue and peripheral blood in patients with Inflammatory Bowel Disease (IBD) as well as establishing and characterizing primary human intestinal organoids from patients.

    I have authored a range of research publications that delve into various topics exploring the role of microbial signals and molecular pathways in intestinal tissue damage, the protective effects of UDP-Glucuronosyltransferase 1A1 against irinotecan-induced toxicity, and the role of nuclear receptor corepressor 1 (NCoR1) in maintaining intestinal homeostasis and protecting from ulcerative colitis.

    Additionally, my work has investigated the regulation of gene expression and the impact of environmental factors on cellular responses in various organisms, including fish and avian species. Through my research efforts, I aim to contribute to the understanding of disease mechanisms and develop novel approaches for improved patient care and outcomes.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Single-cell spatial transcriptomics of fixed, paraffin-embedded biopsies reveals colitis-associated cell networks. bioRxiv. 2024 Nov 11. Mennillo E, Lotstein ML, Lee G, Johri V, Ekstrand C, Tsui J, Hou J, Leet DE, He JY, Mahadevan U, Eckalbar W, Oh DY, Fragiadakis GK, Kattah MG, Combes AJ. PMID: 39605355; PMCID: PMC11601222.
      View in: PubMed   Mentions:
    2. Triclosan administration to humanized UDP-glucuronosyltransferase 1 neonatal mice induces UGT1A1 through a dependence on PPARα and ATF4. J Biol Chem. 2024 Jun; 300(6):107340. Weber AA, Yang X, Mennillo E, Wong S, Le S, Ashley Teo JY, Chang M, Benner CW, Ding J, Jain M, Chen S, Karin M, Tukey RH. PMID: 38705390; PMCID: PMC11152660.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    3. Dysregulation of CD4+ and CD8+ resident memory T, myeloid, and stromal cells in steroid-experienced, checkpoint inhibitor colitis. J Immunother Cancer. 2024 Apr 19; 12(4). He JY, Kim YJ, Mennillo E, Rusu I, Bain J, Rao AA, Andersen C, Law K, Yang H, Tsui J, Shen A, Davidson B, Kushnoor D, Shi Y, Fan F, Cheung A, Zhang L, Fong L, Combes AJ, Pisco AO, Kattah MG, Oh DY. PMID: 38642938; PMCID: PMC11033653.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    4. Single-cell and spatial multi-omics highlight effects of anti-integrin therapy across cellular compartments in ulcerative colitis. Nat Commun. 2024 Feb 19; 15(1):1493. Mennillo E, Kim YJ, Lee G, Rusu I, Patel RK, Dorman LC, Flynn E, Li S, Bain JL, Andersen C, Rao A, Tamaki S, Tsui J, Shen A, Lotstein ML, Rahim M, Naser M, Bernard-Vazquez F, Eckalbar W, Cho SJ, Beck K, El-Nachef N, Lewin S, Selvig DR, Terdiman JP, Mahadevan U, Oh DY, Fragiadakis GK, Pisco A, Combes AJ, Kattah MG. PMID: 38374043; PMCID: PMC10876948.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    5. Single-cell and spatial multi-omics highlight effects of anti-integrin therapy across cellular compartments in ulcerative colitis. bioRxiv. 2024 Jan 03. Mennillo E, Kim YJ, Lee G, Rusu I, Patel RK, Dorman LC, Flynn E, Li S, Bain JL, Andersen C, Rao A, Tamaki S, Tsui J, Shen A, Lotstein ML, Rahim M, Naser M, Bernard-Vazquez F, Eckalbar W, Cho SJ, Beck K, El-Nachef N, Lewin S, Selvig DR, Terdiman JP, Mahadevan U, Oh DY, Fragiadakis GK, Pisco A, Combes AJ, Kattah MG. PMID: 36711576; PMCID: PMC9882264.
      View in: PubMed   Mentions:
    6. Effects of Early Life Oral Arsenic Exposure on Intestinal Tract Development and Lipid Homeostasis in Neonatal Mice: Implications for NAFLD Development. Environ Health Perspect. 2023 09; 131(9):97001. Yang X, Weber AA, Mennillo E, Secrest P, Chang M, Wong S, Le S, Liu J, Benner CW, Karin M, Gordts PLSM, Tukey RH, Chen S. PMID: 37668303; PMCID: PMC10478510.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    7. Oral arsenic administration to humanizedUDP-glucuronosyltransferase1 neonatal mice induces UGT1A1 through a dependence on Nrf2 and PXR. J Biol Chem. 2023 03; 299(3):102955. Yang X, Weber AA, Mennillo E, Paszek M, Wong S, Le S, Teo JYA, Chang M, Benner CW, Tukey RH, Chen S. PMID: 36720308; PMCID: PMC9996368.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    8. Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice. Nat Commun. 2022 07 27; 13(1):4346. Weber AA, Yang X, Mennillo E, Ding J, Watrous JD, Jain M, Chen S, Karin M, Tukey RH. PMID: 35896521; PMCID: PMC9329322.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    9. Microbial signals, MyD88, and lymphotoxin drive TNF-independent intestinal epithelial tissue damage. J Clin Invest. 2022 03 01; 132(5). Rusu I, Mennillo E, Bain JL, Li Z, Sun X, Ly KM, Rosli YY, Naser M, Wang Z, Advincula R, Achacoso P, Shao L, Razani B, Klein OD, Marson A, Turnbaugh JA, Turnbaugh PJ, Malynn BA, Ma A, Kattah MG. PMID: 35077396; PMCID: PMC8884902.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    10. Intestinal UDP-Glucuronosyltransferase 1A1 and Protection against Irinotecan-Induced Toxicity in a Novel UDP-Glucuronosyltransferase 1A1 Tissue-Specific Humanized Mouse Model. Drug Metab Dispos. 2022 01; 50(1):33-42. Mennillo E, Yang X, Weber AA, Maruo Y, Verreault M, Barbier O, Chen S, Tukey RH. PMID: 34697081; PMCID: PMC8969198.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    11. Potential of therapeutic bile acids in the treatment of neonatal Hyperbilirubinemia. Sci Rep. 2021 05 27; 11(1):11107. van der Schoor LWE, Verkade HJ, Bertolini A, de Wit S, Mennillo E, Rettenmeier E, Weber AA, Havinga R, Valášková P, Jašprová J, Struik D, Bloks VW, Chen S, Schreuder AB, Vítek L, Tukey RH, Jonker JW. PMID: 34045606; PMCID: PMC8160219.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    12. Novel organ-specific effects of Ketoprofen and its enantiomer, dexketoprofen on toxicological response transcripts and their functional products in salmon. Aquat Toxicol. 2020 Dec; 229:105677. Mennillo E, Pretti C, Cappelli F, Luci G, Intorre L, Meucci V, Arukwe A. PMID: 33181407.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    13. Regulation of Intestinal UDP-Glucuronosyltransferase 1A1 by the Farnesoid X Receptor Agonist Obeticholic Acid Is Controlled by Constitutive Androstane Receptor through Intestinal Maturation. Drug Metab Dispos. 2021 01; 49(1):12-19. Weber AA, Mennillo E, Yang X, van der Schoor LWE, Jonker JW, Chen S, Tukey RH. PMID: 33154041; PMCID: PMC7745083.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    14. NCoR1 Protects Mice From Dextran Sodium Sulfate-Induced Colitis by Guarding Colonic Crypt Cells From Luminal Insult. Cell Mol Gastroenterol Hepatol. 2020; 10(1):133-147. Mennillo E, Yang X, Paszek M, Auwerx J, Benner C, Chen S. PMID: 32044398; PMCID: PMC7229481.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    15. Differential Role of Liver X Receptor (LXR) α and LXRβ in the Regulation of UDP-Glucuronosyltransferase 1A1 in Humanized UGT1 Mice. Drug Metab Dispos. 2020 04; 48(4):255-263. Hansmann E, Mennillo E, Yoda E, Verreault M, Barbier O, Chen S, Tukey RH. PMID: 31980500; PMCID: PMC7065491.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    16. Quality screening of the Lagos lagoon sediment by assessing the cytotoxicity and toxicological responses of rat hepatoma H4IIE and fish PLHC-1 cell-lines using different extraction approaches. Environ Res. 2020 03; 182:108986. Mennillo E, Adeogun AO, Arukwe A. PMID: 31812937.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    17. Biotransformation and oxidative stress responses in rat hepatic cell-line (H4IIE) exposed to organophosphate esters (OPEs). Toxicol Appl Pharmacol. 2019 05 15; 371:84-94. Mennillo E, Cappelli F, Arukwe A. PMID: 30974155.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    18. Assessing the effects of Awba dam sediment (Nigeria) on the steroidogenesis of H295R cells using different extraction methods. Sci Total Environ. 2019 Feb 10; 650(Pt 1):121-131. Natoli L, Luci G, Mennillo E, Adeogun AO, Arukwe A. PMID: 30196212.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    19. Biotransformation and oxidative stress responses in rat hepatic cell-line (H4IIE) exposed to racemic ketoprofen (RS-KP) and its enantiomer, dexketoprofen (S(+)-KP). Environ Toxicol Pharmacol. 2018 Apr; 59:199-207. Mennillo E, Krøkje Å, Pretti C, Meucci V, Arukwe A. PMID: 29626791.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    20. Ecotoxicological properties of ketoprofen and the S(+)-enantiomer (dexketoprofen): Bioassays in freshwater model species and biomarkers in fish PLHC-1 cell line. Environ Toxicol Chem. 2018 01; 37(1):201-212. Mennillo E, Arukwe A, Monni G, Meucci V, Intorre L, Pretti C. PMID: 28796322.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    21. Oxidative stress responses in relationship to persistent organic pollutant levels in feathers and blood of two predatory bird species from Pakistan. Sci Total Environ. 2017 Feb 15; 580:26-33. Abbasi NA, Arukwe A, Jaspers VLB, Eulaers I, Mennilo E, Ibor OR, Frantz A, Covaci A, Malik RN. PMID: 27939994.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    22. Suitability of cholinesterase of polychaete Diopatra neapolitana as biomarker of exposure to pesticides: In vitro characterization. Comp Biochem Physiol C Toxicol Pharmacol. 2017 Jan; 191:152-159. Mennillo E, Casu V, Tardelli F, De Marchi L, Freitas R, Pretti C. PMID: 27777085.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCellsPHPublic Health
    23. The serpulid Ficopomatus enigmaticus () as candidate organisms for ecotoxicological assays in brackish and marine waters. Ecotoxicol Environ Saf. 2018 Feb; 148:1096-1103. Oliva M, Mennillo E, Barbaglia M, Monni G, Tardelli F, Casu V, Pretti C. PMID: 26598046.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    24. Photopolymerized Network Polysiloxane Films with Dangling Hydrophilic/Hydrophobic Chains for the Biofouling Release of Invasive Marine Serpulid Ficopomatus enigmaticus. ACS Appl Mater Interfaces. 2015 Apr 22; 7(15):8293-301. Martinelli E, Del Moro I, Galli G, Barbaglia M, Bibbiani C, Mennillo E, Oliva M, Pretti C, Antonioli D, Laus M. PMID: 25835588.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsPHPublic Health
    25. An ecotoxicological study on tin- and bismuth-catalysed PDMS based coatings containing a surface-active polymer. Ecotoxicol Environ Saf. 2013 Dec; 98:250-6. Pretti C, Oliva M, Mennillo E, Barbaglia M, Funel M, Reddy Yasani B, Martinelli E, Galli G. PMID: 24125869.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCellsPHPublic Health
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