Michael Kattah, MD, PhD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
ORCID ORCID Icon0000-0002-6067-6585 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Stanford UniversityMD/PhD2010Medicine
    Brigham and Women's HospitalMedicine Residency2012Medicine
    UCSFGastroenterology Fellowship2016Gastroenterology/Medicine
    Collapse Awards and Honors
    Stanford University2008Hugh McDevitt Award
    Brigham and Women's Hospital2012Resident Mentoring Award
    DDW 20162016Recognition for Scientific Accomplishment as an Early Stage Investigator
    American Society for Clinical Investigation2021Young Physician Scientist Award

    Collapse Overview 
    Collapse Overview
    As an Assistant Professor in the Division of GI at UCSF, I am interested in the molecular underpinnings of intestinal inflammation and Inflammatory Bowel Disease (IBD). We employ a variety of tools to study intestinal epithelial cells and death signaling pathways in mouse models, patient-derived biopsies, and organoids.
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    Collapse Research 
    Collapse Research Activities and Funding
    Tabula Sapiens
    Chan-Zuckerberg Biohub Sep 1, 2022 - Aug 31, 2023
    Role: Intestine lead, co-investigator
    Description: Creation of a multiple-organ, human, single-cell transcriptomic atlas
    AutoImmunoprofiler (AutoIPI)
    Eli Lilly P0542258Mar 1, 2021 - Jun 28, 2023
    Role: IBD lead, co-Investigator
    Description: To profile a range of autoimmune diseases using a combination of proteomic, transcriptomic, epigenomic, and structural analyses.
    Mechanisms of intestinal epithelial injury in intestinal inflammation
    NIH K08DK123202Jan 16, 2020 - Nov 30, 2024
    Role: Principal Investigator
    A20 and ABIN-1 cooperatively preserve intestinal integrity
    Burroughs Wellcome Fund Career Awards for Medical Scientists 1019583.01Jan 1, 2020 - Aug 31, 2025
    Role: Principal Investigator
    Clinical cohort and corresponding cell atlas for patients with intestinal inflammation
    Department of Medicine UCSF DOM Cohort GrantJul 1, 2019 - Jun 30, 2021
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Single-cell and spatial multi-omics identify innate and stromal modules targeted by anti-integrin therapy in ulcerative colitis. bioRxiv. 2023 Jul 15. Mennillo E, Kim YJ, Rusu I, Lee G, Dorman LC, Bernard-Vazquez F, Bain JL, Patel R, Andersen C, Rao A, Tamaki S, Tsui J, Shen A, Naser M, Eckalbar W, Cho SJ, Beck K, El-Nachef N, Lewin S, Selvig DR, Terdiman JP, Mahadevan U, Oh D, Fragiadakis GK, Pisco A, Combes A, Kattah MG. PMID: 36711576; PMCID: PMC9882264.
      View in: PubMed   Mentions:
    2. 630 SINGLE-CELL AND SPATIAL MULTI-OMICS IDENTIFY INNATE AND STROMAL MODULES TARGETED BY ANTI-INTEGRIN THERAPY IN ULCERATIVE COLITIS. Gastroenterology. 2023 May 1; 164(6):s-124. Mennillo ME, Kim KY, Rusu RI, Lee LG, Dorman DL, Bernard-Vazquez BF, Bain BJ, Patel PR, Andersen AC, Tamaki TS, Tsui TJ, Beck BK, El-Nachef EN, Lewin LS, Selvig SD, Terdiman TJ, Mahadevan MU, Oh OD, Fragiadakis FG, Pisco PA, Combes CA, Kattah KM. .
      View in: Publisher Site   Mentions:
    3. A20 Restricts NOS2 Expression and Intestinal Tumorigenesis in a Mouse Model of Colitis-Associated Cancer. Gastro Hep Adv. 2023; 2(1):96-107. Basta DW, Vong M, Beshimova A, Nakamura BN, Rusu I, Kattah MG, Shao L. PMID: 36636264; PMCID: PMC9833806.
      View in: PubMed   Mentions:
    4. Vedolizumab Antagonizes MAdCAM-1-Dependent Human Placental Cytotrophoblast Adhesion and Invasion In Vitro. Inflamm Bowel Dis. 2022 08 01; 28(8):1219-1228. Blaisdell A, Zhou Y, Kattah MG, Fisher SJ, Mahadevan U. PMID: 35349682.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    5. Intestinal inflammation alters the antigen-specific immune response to a skin commensal. Cell Rep. 2022 05 31; 39(9):110891. Merana GR, Dwyer LR, Dhariwala MO, Weckel A, Gonzalez JR, Okoro JN, Cohen JN, Tamaki CM, Han J, Tasoff P, Palacios-Calderon Y, Ha CWY, Lynch SV, Segre JA, Kong HH, Kattah MG, Ma A, Scharschmidt TC. PMID: 35649365; PMCID: PMC9248974.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    6. Tu1517: MICROBIAL SIGNALS, MYD88, AND LYMPHOTOXIN DRIVE TNFINDEPENDENT DEATH OF A20 AND ABIN-1 DEFICIENT EPITHELIUM. Gastroenterology. 2022 May 1; 162(7):s-995. Rusu RI, Mennillo ME, Bain BJ, Li LZ, Sun SX, Ly LK, Rosli RY, Naser NM, Wang WZ, Advincula AR, Achacoso AP, Shao SL, Razani RB, Klein KO, Marson MA, Turnbaugh TJ, Turnbaugh TP, Malynn MB, Ma MA, Kattah KM. .
      View in: Publisher Site   Mentions:
    7. Microbial signals, MyD88, and lymphotoxin drive TNF-independent intestinal epithelial tissue damage. J Clin Invest. 2022 03 01; 132(5). Rusu I, Mennillo E, Bain JL, Li Z, Sun X, Ly KM, Rosli YY, Naser M, Wang Z, Advincula R, Achacoso P, Shao L, Razani B, Klein OD, Marson A, Turnbaugh JA, Turnbaugh PJ, Malynn BA, Ma A, Kattah MG. PMID: 35077396; PMCID: PMC8884902.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    8. Importance of Not MSing Cerebral White Matter Disease in Patients with Inflammatory Bowel Disease. Dig Dis Sci. 2020 09; 65(9):2527-2532. Regner EH, Green AJ, Bain JL, Kattah MG, Mahadevan U. PMID: 32651742.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. A20 in dendritic cells restrains intestinal anti-bacterial peptide expression and preserves commensal homeostasis. PLoS One. 2019; 14(7):e0218999. Talpin A, Kattah MG, Advincula R, Fadrosh D, Lynch K, LaMere B, Fujimura KE, Nagalingam NA, Malynn BA, Lynch SV, Ma A. PMID: 31295268; PMCID: PMC6622485.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    10. Balancing the Checkpoint: Managing Colitis Associated with Dual Checkpoint Inhibitors and High-Dose Aspirin. Dig Dis Sci. 2019 03; 64(3):685-688. Hammami MB, Gill R, Thiruvengadam N, Oh DY, Beck K, Mahadevan U, Kattah MG. PMID: 30778872.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Correction: Anti-TNF and thiopurine therapy in pregnant IBD patients does not significantly alter a panel of B-cell and T-cell subsets in 1-year-old infants. Clin Transl Gastroenterol. 2018 07 31; 9(7):172. Kattah MG, Milush JM, Burt T, McCabe RP, Whang MI, Ma A, Mahadevan U. PMID: 30065242; PMCID: PMC6068199.
      View in: PubMed   Mentions:    Fields:    
    12. A20 and ABIN-1 synergistically preserve intestinal epithelial cell survival. J Exp Med. 2018 07 02; 215(7):1839-1852. Kattah MG, Shao L, Rosli YY, Shimizu H, Whang MI, Advincula R, Achacoso P, Shah S, Duong BH, Onizawa M, Tanbun P, Malynn BA, Ma A. PMID: 29930103; PMCID: PMC6028510.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    13. Effect of I-scan Electronic Chromoendoscopy on Detection of Adenomas During Colonoscopy. Clin Gastroenterol Hepatol. 2019 03; 17(4):701-708.e1. Kidambi TD, Terdiman JP, El-Nachef N, Singh A, Kattah MG, Lee JK. PMID: 29935326.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    14. A20 regulates canonical wnt-signaling through an interaction with RIPK4. PLoS One. 2018; 13(5):e0195893. Nakamura BN, Glazier A, Kattah MG, Duong B, Jia Y, Campo D, Shao L. PMID: 29718933; PMCID: PMC5931457.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    15. Anti-TNF and thiopurine therapy in pregnant IBD patients does not significantly alter a panel of B-cell and T-cell subsets in 1-year-old infants. Clin Transl Gastroenterol. 2018 04 03; 9(4):143. Kattah MG, Milush JM, Burt T, McCabe RP, Whang MI, Ma A, Mahadevan U. PMID: 29618720; PMCID: PMC5886978.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    16. A20 upregulation during treated HIV disease is associated with intestinal epithelial cell recovery and function. PLoS Pathog. 2018 03; 14(3):e1006806. Chitre AS, Kattah MG, Rosli YY, Pao M, Deswal M, Deeks SG, Hunt PW, Abdel-Mohsen M, Montaner LJ, Kim CC, Ma A, Somsouk M, McCune JM. PMID: 29505600; PMCID: PMC5854440.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    17. Ubiquitin-Modifying Enzymes and Regulation of the Inflammasome. J Mol Biol. 2017 11 10; 429(22):3471-3485. Kattah MG, Malynn BA, Ma A. PMID: 29031697; PMCID: PMC5675782.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    18. 332e Multiparameter Flow Cytometry Reveals Differences in B Cells Subsets among Infants Born to Mothers being Treated for IBD. Gastroenterology. 2017 Apr 1; 152(5):s86. Kattah KM, Milush MJ, Burt BT, Mahadevan MU. .
      View in: Publisher Site   Mentions:
    19. The Ubiquitin Binding Protein TAX1BP1 Mediates Autophagasome Induction and the Metabolic Transition of Activated T Cells. Immunity. 2017 03 21; 46(3):405-420. Whang MI, Tavares RM, Benjamin DI, Kattah MG, Advincula R, Nomura DK, Debnath J, Malynn BA, Ma A. PMID: 28314591; PMCID: PMC5400745.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    20. P-285 A20 and ABIN-1 Cooperate to Preserve Intestinal Epithelial Homeostasis. Inflammatory Bowel Diseases. 2017 Feb 1; 23(&NA;):s92. Kattah KM, Shao SL, Rosli RY, Whang WM, Advincula AR, Malynn MB, Ma MA. .
      View in: Publisher Site   Mentions:
    21. Effect of Intense Exercise on Inflammatory Bowel Disease Activity. The American Journal of Gastroenterology. 2016 Oct 1; 111:s312. Hassid HB, Lamere LB, Kattah KM, Mahadevan MU. .
      View in: Publisher Site   Mentions:
    22. 245 A20 and ABIN-1 Cooperate to Restrict Intestinal Epithelial Cell Death and Maintain Mucosal Immune Homeostasis. Gastroenterology. 2016 Apr 1; 150(4):s59. Shao SL, Kattah KM, Whang WM, Duong DB, Onizawa OM, Abbasi AS, Rosli RY, Callahan CJ, Pendse PM, Barrera BJ, Glazier GA, Advincula AR, Malynn MB, Ma MA. .
      View in: Publisher Site   Mentions:
    23. Confocal laser endomicroscopy for membrane-bound tumor necrosis factor predicts response to therapy in Crohn's disease. Gastroenterology. 2015 May; 148(5):1067-9. Kattah MG, Mahadevan U. PMID: 25824357.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    24. Tetramers reveal IL-17-secreting CD4+ T cells that are specific for U1-70 in lupus and mixed connective tissue disease. Proc Natl Acad Sci U S A. 2015 Mar 10; 112(10):3044-9. Kattah NH, Newell EW, Jarrell JA, Chu AD, Xie J, Kattah MG, Goldberger O, Ye J, Chakravarty EF, Davis MM, Utz PJ. PMID: 25713364; PMCID: PMC4364210.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    25. Measurement of mast cell surface molecules by high-throughput immunophenotyping using transcription (HIT). Methods Mol Biol. 2015; 1220:381-400. Haddon DJ, Jarrell JA, Hughes MR, Snyder K, McNagny KM, Kattah MG, Utz PJ. PMID: 25388264.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    26. Insights into the molecular pathophysiology of inflammatory bowel disease: ATG16L1 suppresses nod-driven inflammation. Gastroenterology. 2014 Aug; 147(2):528-30. Kattah MG, Mahadevan U. PMID: 24953625.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    27. The U1-snRNP complex: structural properties relating to autoimmune pathogenesis in rheumatic diseases. Immunol Rev. 2010 Jan; 233(1):126-45. Kattah NH, Kattah MG, Utz PJ. PMID: 20192997; PMCID: PMC3074261.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    28. Antigen Specific T Cells in Lupus Recognize U1-70 and Produce IL-17 by Tetramer Staining. Clinical Immunology. 2010 Jan 1; 135:s9. Kattah KN, Newell NE, Chu CA, Kattah KM, Davis DM. .
      View in: Publisher Site   Mentions:
    29. Naive CD4 t cell proliferation is controlled by mammalian target of rapamycin regulation of GRAIL expression. J Immunol. 2009 May 15; 182(10):5919-28. Lin JT, Lineberry NB, Kattah MG, Su LL, Utz PJ, Fathman CG, Wu L. PMID: 19414743; PMCID: PMC2853371.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    30. OR.85. Regulation of GRAIL Expression by mTOR Controls Naive CD4 T Cell Proliferation. Clinical Immunology. 2009 Jan 1; 131:s35-s36. Lin LJ, Lineberry LN, Kattah KM, Su SL, Utz UP, Fathman FC. .
      View in: Publisher Site   Mentions:
    31. Differential regulation of chemokines by IL-17 in colonic epithelial cells. J Immunol. 2008 Nov 01; 181(9):6536-45. Lee JW, Wang P, Kattah MG, Youssef S, Steinman L, DeFea K, Straus DS. PMID: 18941244.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    32. Protein microarrays with carbon nanotubes as multicolor Raman labels. Nat Biotechnol. 2008 Nov; 26(11):1285-92. Chen Z, Tabakman SM, Goodwin AP, Kattah MG, Daranciang D, Wang X, Zhang G, Li X, Liu Z, Utz PJ, Jiang K, Fan S, Dai H. PMID: 18953353.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimals
    33. HIT: a versatile proteomics platform for multianalyte phenotyping of cytokines, intracellular proteins and surface molecules. Nat Med. 2008 Nov; 14(11):1284-9. Kattah MG, Coller J, Cheung RK, Oshidary N, Utz PJ. PMID: 18849997; PMCID: PMC3334282.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    34. Protein microarrays address the elephant in the room. Clin Chem. 2008 Jun; 54(6):937-9. Kattah MG, Utz PJ, Balboni I. PMID: 18509011.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    35. Cytokines secreted in response to Toll-like receptor ligand stimulation modulate differentiation of human Th17 cells. Arthritis Rheum. 2008 Jun; 58(6):1619-29. Kattah MG, Wong MT, Yocum MD, Utz PJ. PMID: 18512782; PMCID: PMC4124044.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    36. Sa.95. HIT: A Novel Protein Array Platform Identifies Down-regulation of CD26 on Regulatory T Cell Subsets. Clinical Immunology. 2008 Jan 1; 127:s111-s112. Kattah KM, Coller CJ, Cheung CR, Oshidary ON, Utz UP. .
      View in: Publisher Site   Mentions:
    37. OR.40. Cytokines Secreted in Response to TLR-ligand Stimulation Modulate Human Th17 Differentiation. Clinical Immunology. 2008 Jan 1; 127:s18. Kattah KM, Wong WM, Yocum YM, Utz UP. .
      View in: Publisher Site   Mentions:
    38. Sa.12. Profiling Epigenetic Biomarkers for the Study and Treatment of Lupus. Clinical Immunology. 2008 Jan 1; 127:s84. Liu LC, Kattah KM, Kuo KA, Shi SX, Balboni BI, Utz UP, Gozani GO. .
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    39. Free-solution oligonucleotide separation in nanoscale channels. Anal Chem. 2007 Nov 01; 79(21):8316-22. Pennathur S, Baldessari F, Santiago JG, Kattah MG, Steinman JB, Utz PJ. PMID: 17883279.
      View in: PubMed   Mentions: 17     Fields:    
    40. Antibody-oligo Arrays for Multiplex Surface Marker Profiling of Immune Cells Subsets. Clinical Immunology. 2007 Jan 1; 123:s185. Kattah KM, Coller CJ, Alemi AG, Oshidary ON, Utz UP. .
      View in: Publisher Site   Mentions:
    41. A new two-color Fab labeling method for autoantigen protein microarrays. Nat Methods. 2006 Sep; 3(9):745-51. Kattah MG, Alemi GR, Thibault DL, Balboni I, Utz PJ. PMID: 16929321.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    42. Medicine on a need-to-know basis. Nat Immunol. 2006 Jun; 7(6):543-7. Busch R, Byrne B, Gandrud L, Sears D, Meyer E, Kattah M, Kurihara C, Haertel E, Parnes JR, Mellins ED. PMID: 16715061.
      View in: PubMed   Mentions: 4     Fields:    
    43. Multiplexed protein array platforms for analysis of autoimmune diseases. Annu Rev Immunol. 2006; 24:391-418. Balboni I, Chan SM, Kattah M, Tenenbaum JD, Butte AJ, Utz PJ. PMID: 16551254.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    44. Sa.127. A Novel Two-Color Fab Labeling Method for Autoantigen Protein Microarrays. Clinical Immunology. 2006 Jan 1; 119:s150. Kattah KM, Alemi AG, Thibault TD, Utz UP. .
      View in: Publisher Site   Mentions:
    45. Structure-based discovery of nonpeptidic small organic compounds to block the T cell response to myelin basic protein. J Med Chem. 2004 Oct 07; 47(21):4989-97. Koehler NK, Yang CY, Varady J, Lu Y, Wu XW, Liu M, Yin D, Bartels M, Xu BY, Roller PP, Long YQ, Li P, Kattah M, Cohn ML, Moran K, Tilley E, Richert JR, Wang S. PMID: 15456243.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    46. Crystal structure of the human myeloid cell activating receptor TREM-1. Structure. 2003 Dec; 11(12):1527-35. Radaev S, Kattah M, Rostro B, Colonna M, Sun PD. PMID: 14656437.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    47. Generating isomorphous heavy-atom derivatives by a quick-soak method. Part I: test cases. Acta Crystallogr D Biol Crystallogr. 2002 Jul; 58(Pt 7):1092-8. Sun PD, Radaev S, Kattah M. PMID: 12077427.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells