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Farid Chehab, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentLaboratory Medicine
Address185 Berry Street Bldg B
San Francisco CA 94158
Phone415-476-0310
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    LEPTIN AND INITIATION OF REPRODUCTIVE FUNCTION
    NIH/NICHD R01HD035142May 1, 1998 - Apr 30, 2004
    Role: Principal Investigator
    GENE THERAPY STRATEGIES FOR SICKLE CELL DISEASE
    NIH/NHLBI P01HL053762Sep 30, 1994 - Aug 31, 2007
    Role: Co-Investigator
    GENE THERAPY CORE--CYSTIC FIBROSIS &NON-CF GENETIC DIS
    NIH/NIDDK P30DK047766Sep 30, 1993 - Aug 31, 1999
    Role: Co-Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Jai SR, Farah RH, Hamdaoui B, Boufettal R, Chehab F. Pleomorphous leiomyosarcoma of the mesocolon: a case report. Pan Afr Med J. 2015; 22:322. PMID: 26977231; PMCID: PMC4769802.
    2. Lasater EA, Massi ES, Stecula A, Politi J, Tan SK, Smith CC, Gunthorpe M, Holmes JP, Chehab F, Sali A, Shah NP. Novel TKI-resistant BCR-ABL1 gatekeeper residue mutations retain in vitro sensitivity to axitinib. Leukemia. 2016 Jun; 30(6):1405-9. PMID: 26511402.
      View in: PubMed
    3. Boufettal R, Fahmi Y, Jai SR, Chehab F. Videocapsule retention: role of surgical treatment (a case report). Pan Afr Med J. 2015; 22:64. PMID: 26834917; PMCID: PMC4725649.
    4. Eljai RS, Boufettal R, Farah RH, Chehab F. [Pancreatic hydatid cyst: a case about]. Pan Afr Med J. 2015; 21:273. PMID: 26587123; PMCID: PMC4634024.
    5. Boufettal R, Elbakouri A, Jai SR, Chehab F. [Pancreatic heterotopia as an unusual cause of upper gastrointestinal bleeding]. Presse Med. 2015 Mar; 44(3):368-9. PMID: 25534468.
      View in: PubMed
    6. Zouheir Habbal M, Bou-Assi T, Zhu J, Owen R, Chehab F. First report of a deletion encompassing an entire exon in the homogentisate 1,2-dioxygenase gene causing alkaptonuria. PLoS One. 2014; 9(9):e106948. PMID: 25233259; PMCID: PMC4169433.
    7. Chehab F. 20 years of leptin: leptin and reproduction: past milestones, present undertakings, and future endeavors. J Endocrinol. 2014 Oct; 223(1):T37-48. PMID: 25118207; PMCID: PMC4184910.
    8. Zhu J, Jiang X, Chehab F. FoxO4 interacts with the sterol regulatory factor SREBP2 and the hypoxia inducible factor HIF2a at the CYP51 promoter. J Lipid Res. 2014 Mar; 55(3):431-42. PMID: 24353279; PMCID: PMC3934728.
    9. Zhu J, Qiu J, Magrane G, Abedalthagafi M, Zanko A, Golabi M, Chehab F. Duplication of C7orf58, WNT16 and FAM3C in an obese female with a t(7;22)(q32.1;q11.2) chromosomal translocation and clinical features resembling Coffin-Siris Syndrome. PLoS One. 2012; 7(12):e52353. PMID: 23300646; PMCID: PMC3531478.
    10. Van Ziffle J, Yang W, Chehab F. Homozygous deletion of six olfactory receptor genes in a subset of individuals with Beta-thalassemia. PLoS One. 2011 Feb 24; 6(2):e17327. PMID: 21390308; PMCID: PMC3044735.
    11. Zhu J, Mounzih K, Chehab EF, Mitro N, Saez E, Chehab F. Effects of FoxO4 overexpression on cholesterol biosynthesis, triacylglycerol accumulation, and glucose uptake. J Lipid Res. 2010 Jun; 51(6):1312-24. PMID: 20037138; PMCID: PMC3035494.
    12. Wang B, Zhu J, Mounzih K, Chehab EF, Ke Y, Chehab F. Overexpression of the transcription factor Foxo4 is associated with rapid glucose clearance. Mol Cell Endocrinol. 2009 Aug 13; 307(1-2):217-23. PMID: 19410631.
      View in: PubMed
    13. Chehab F. Obesity and lipodystrophy--where do the circles intersect? Endocrinology. 2008 Mar; 149(3):925-34. PMID: 18202137; PMCID: PMC2275358.
    14. Wang B, Chehab F. Deletion of the serotonin 2c receptor from transgenic mice overexpressing leptin does not affect their lipodystrophy but exacerbates their diet-induced obesity. Biochem Biophys Res Commun. 2006 Dec 15; 351(2):418-23. PMID: 17064660; PMCID: PMC1941709.
    15. Han XD, Powell BR, Phalin JL, Chehab F. Mosaicism for a full mutation, premutation, and deletion of the CGG repeats results in 22% FMRP and elevated FMR1 mRNA levels in a high-functioning fragile X male. Am J Med Genet A. 2006 Jul 01; 140(13):1463-71. PMID: 16761284.
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    16. Chehab F, Qiu J, Ogus S. The use of animal models to dissect the biology of leptin. Recent Prog Horm Res. 2004; 59:245-66. PMID: 14749505.
      View in: PubMed
    17. Ke Y, Qiu J, Ogus S, Shen WJ, Kraemer FB, Chehab F. Overexpression of leptin in transgenic mice leads to decreased basal lipolysis, PKA activity, and perilipin levels. Biochem Biophys Res Commun. 2003 Dec 26; 312(4):1165-70. PMID: 14651995.
      View in: PubMed
    18. Ogus S, Ke Y, Qiu J, Wang B, Chehab F. Hyperleptinemia precipitates diet-induced obesity in transgenic mice overexpressing leptin. Endocrinology. 2003 Jul; 144(7):2865-9. PMID: 12810541.
      View in: PubMed
    19. Chehab F, Qiu J, Mounzih K, Ewart-Toland A, Ogus S. Leptin and reproduction. Nutr Rev. 2002 Oct; 60(10 Pt 2):S39-46; discussion S68-84, 85-7. PMID: 12403083.
      View in: PubMed
    20. Qiu J, Ogus S, Mounzih K, Ewart-Toland A, Chehab F. Leptin-deficient mice backcrossed to the BALB/cJ genetic background have reduced adiposity, enhanced fertility, normal body temperature, and severe diabetes. Endocrinology. 2001 Aug; 142(8):3421-5. PMID: 11459786.
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    21. Qiu J, Ogus S, Lu R, Chehab F. Transgenic Mice Overexpressing Leptin Accumulate Adipose Mass at an Older, But Not Younger, Age* * This work was funded by NIH Grant HD-35142. Endocrinology. 2001 Jan 01; 142(1):348-358. PMID: 28201341.
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    22. Qiu J, Ogus S, Lu R, Chehab F. Transgenic mice overexpressing leptin accumulate adipose mass at an older, but not younger, age. Endocrinology. 2001 Jan; 142(1):348-58. PMID: 11145598.
      View in: PubMed
    23. Chehab F. Leptin as a regulator of adipose mass and reproduction. Trends Pharmacol Sci. 2000 Aug; 21(8):309-14. PMID: 10918637.
      View in: PubMed
    24. Ewart-Toland A, Mounzih K, Qiu J, Chehab F. Effect of the genetic background on the reproduction of leptin-deficient obese mice. Endocrinology. 1999 Feb; 140(2):732-8. PMID: 9927300.
      View in: PubMed
    25. Mounzih K, Qiu J, Ewart-Toland A, Chehab F. Leptin is not necessary for gestation and parturition but regulates maternal nutrition via a leptin resistance state. Endocrinology. 1998 Dec; 139(12):5259-62. PMID: 9832467.
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    26. Chehab F, Khaiz D, Lakhloufi A, Bouzidi A. [Ovarian teratoma prolapsed into the rectum]. Ann Chir. 1998; 52(1):101. PMID: 9752424.
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    27. Vuillaumier S, Dixmeras I, Messa√Į H, Lapoum√©roulie C, Lallemand D, Gekas J, Chehab F, Perret C, Elion J, Denamur E. Cross-species characterization of the promoter region of the cystic fibrosis transmembrane conductance regulator gene reveals multiple levels of regulation. Biochem J. 1997 Nov 01; 327 ( Pt 3):651-62. PMID: 9581539; PMCID: PMC1218840.
    28. Ballas SK, Gay RN, Chehab F. Is Hb A2 elevated in adults with sickle-alpha-thalassemia (beta(S)/beta(S); -alpha/-alpha)? Hemoglobin. 1997 Sep; 21(5):405-50. PMID: 9322076.
      View in: PubMed
    29. Chehab F. The reproductive side of leptin. Nat Med. 1997 Sep; 3(9):952-3. PMID: 9288714.
      View in: PubMed
    30. Ballas SK, Cai SP, Gabuzda T, Chehab F. Molecular basis of asymptomatic beta-thalassemia major in an African American individual. Am J Med Genet. 1997 Mar 17; 69(2):196-9. PMID: 9056561.
      View in: PubMed
    31. Mounzih K, Lu R, Chehab F. Leptin treatment rescues the sterility of genetically obese ob/ob males. Endocrinology. 1997 Mar; 138(3):1190-3. PMID: 9048626.
      View in: PubMed
    32. Chehab F, Mounzih K, Lu R, Lim ME. Early onset of reproductive function in normal female mice treated with leptin. Science. 1997 Jan 03; 275(5296):88-90. PMID: 8974400.
      View in: PubMed
    33. Hofferbert S, Schanen NC, Chehab F, Francke U. Trinucleotide repeats in the human genome: size distributions for all possible triplets and detection of expanded disease alleles in a group of Huntington disease individuals by the repeat expansion detection method. Hum Mol Genet. 1997 Jan; 6(1):77-83. PMID: 9002673.
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    34. Chehab F. A broader role for leptin. Nat Med. 1996 Jul; 2(7):723-4. PMID: 8673906.
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    35. Chehab F, Lim ME, Lu R. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet. 1996 Mar; 12(3):318-20. PMID: 8589726.
      View in: PubMed
    36. York MK, Gibbs L, Chehab F, Brooks GF. Comparison of PCR detection of mecA with standard susceptibility testing methods to determine methicillin resistance in coagulase-negative staphylococci. J Clin Microbiol. 1996 Feb; 34(2):249-53. PMID: 8788995; PMCID: PMC228777.
    37. Cai S, Chehab F. New frameshift mutation, insertion of A, at codon 95 of the beta-globin gene causes beta-thalassemia in two Vietnamese families. Hum Mutat. 1996; 8(3):293-4. PMID: 8889595.
      View in: PubMed
    38. McLean LK, Chehab F, Goldberg JD. Detection of viral deoxyribonucleic acid in the amniotic fluid of low-risk pregnancies by polymerase chain reaction. Am J Obstet Gynecol. 1995 Oct; 173(4):1282-6. PMID: 7485338.
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    39. Denamur E, Chehab F. Methylation status of CpG sites in the mouse and human CFTR promoters. DNA Cell Biol. 1995 Sep; 14(9):811-5. PMID: 7545404.
      View in: PubMed
    40. Wall J, Cai S, Chehab F. A 31-mutation assay for cystic fibrosis testing in the clinical molecular diagnostics laboratory. Hum Mutat. 1995; 5(4):333-8. PMID: 7627189.
      View in: PubMed
    41. Eggerding FA, Schonberg SA, Chehab F, Norton ME, Cox VA, Epstein CJ. Uniparental isodisomy for paternal 7p and maternal 7q in a child with growth retardation. Am J Hum Genet. 1994 Aug; 55(2):253-65. PMID: 7913578; PMCID: PMC1918369.
    42. Denamur E, Chehab F. Analysis of the mouse and rat CFTR promoter regions. Hum Mol Genet. 1994 Jul; 3(7):1089-94. PMID: 7526924.
      View in: PubMed
    43. Kawasaki ES, Chehab F. Analysis of gene sequences by hybridization of PCR-amplified DNA to covalently bound oligonucleotide probes. The reverse dot blot method. Methods Mol Biol. 1994; 28:225-36. PMID: 8118512.
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    44. Jain PK, Dozy AM, Verma IC, Chehab F. A new frameshift mutation, insertion of ATCT, at codon 48 in the beta-globin gene causes beta-thalassemia in an Indian proband. Hum Mutat. 1994; 3(4):397-8. PMID: 8081396.
      View in: PubMed
    45. Cai SP, Wall J, Kan YW, Chehab F. Reverse dot blot probes for the screening of beta-thalassemia mutations in Asians and American blacks. Hum Mutat. 1994; 3(1):59-63. PMID: 8118466.
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    46. Chehab F. Molecular diagnostics: past, present, and future. Hum Mutat. 1993; 2(5):331-7. PMID: 8257984.
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    47. Maggio A, Giambona A, Cai SP, Wall J, Kan YW, Chehab F. Rapid and simultaneous typing of hemoglobin S, hemoglobin C, and seven Mediterranean beta-thalassemia mutations by covalent reverse dot-blot analysis: application to prenatal diagnosis in Sicily. Blood. 1993 Jan 01; 81(1):239-42. PMID: 8417793.
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    48. Chehab F, Wall J. Detection of multiple cystic fibrosis mutations by reverse dot blot hybridization: a technology for carrier screening. Hum Genet. 1992 May; 89(2):163-8. PMID: 1587526.
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    49. Fiss EH, Chehab F, Brooks GF. DNA amplification and reverse dot blot hybridization for detection and identification of mycobacteria to the species level in the clinical laboratory. J Clin Microbiol. 1992 May; 30(5):1220-4. PMID: 1583123; PMCID: PMC265254.
    50. Chehab F, Wall J, Kan YW. Amplification and detection of specific DNA sequences with fluorescent PCR primers: application to delta F508 mutation in cystic fibrosis. Methods Enzymol. 1992; 216:135-43. PMID: 1479898.
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    51. Chehab F, Johnson J, Louie E, Goossens M, Kawasaki E, Erlich H. A dimorphic 4-bp repeat in the cystic fibrosis gene is in absolute linkage disequilibrium with the delta F508 mutation: implications for prenatal diagnosis and mutation origin. Am J Hum Genet. 1991 Feb; 48(2):223-6. PMID: 1990833; PMCID: PMC1683013.
    52. Embury SH, Kropp GL, Stanton TS, Warren TC, Cornett PA, Chehab F. Detection of the hemoglobin E mutation using the color complementation assay: application to complex genotyping. Blood. 1990 Aug 01; 76(3):619-23. PMID: 2378988.
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    53. Chehab F, Kan YW. Detection of sickle cell anaemia mutation by colour DNA amplification. Lancet. 1990 Jan 06; 335(8680):15-7. PMID: 1967329.
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    54. Dozy AM, Cai SP, Chehab F, Kan YW. The use of direct gene analysis to define beta-thalassemia. Ann N Y Acad Sci. 1990; 612:22-30. PMID: 2291549.
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    55. Chehab F, Kan YW. Detection of specific DNA sequences by fluorescence amplification: a color complementation assay. Proc Natl Acad Sci U S A. 1989 Dec; 86(23):9178-82. PMID: 2594760; PMCID: PMC298457.
    56. Chehab F, Winterhalter KH, Kan YW. Characterization of a spontaneous mutation in beta-thalassemia associated with advanced paternal age. Blood. 1989 Aug 01; 74(2):852-4. PMID: 2665856.
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    57. Chehab F, Xiao X, Kan YW, Yen TS. Detection of cytomegalovirus infection in paraffin-embedded tissue specimens with the polymerase chain reaction. Mod Pathol. 1989 Mar; 2(2):75-8. PMID: 2542930.
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    58. Zhang JZ, Cai SP, He X, Lin HX, Lin HJ, Huang ZG, Chehab F, Kan YW. Molecular basis of beta thalassemia in south China. Strategy for DNA analysis. Hum Genet. 1988 Jan; 78(1):37-40. PMID: 3338793.
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    59. Chehab F, Kan YW, Law ML, Hartz J, Kao FT, Blostein R. Human placental Na+,K+-ATPase alpha subunit: cDNA cloning, tissue expression, DNA polymorphism, and chromosomal localization. Proc Natl Acad Sci U S A. 1987 Nov; 84(22):7901-5. PMID: 2891135; PMCID: PMC299443.
    60. Chehab F, Doherty M, Cai SP, Kan YW, Cooper S, Rubin EM. Detection of sickle cell anaemia and thalassaemias. Nature. 1987 Sep 24-30; 329(6137):293-4. PMID: 3627274.
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    61. Shelton-Inloes BB, Chehab F, Mannucci PM, Federici AB, Sadler JE. Gene deletions correlate with the development of alloantibodies in von Willebrand disease. J Clin Invest. 1987 May; 79(5):1459-65. PMID: 3033024; PMCID: PMC424419.
    62. Chehab F, Der Kaloustian V, Khouri FP, Deeb SS, Kan YW. The molecular basis of beta-thalassemia in Lebanon: application to prenatal diagnosis. Blood. 1987 Apr; 69(4):1141-5. PMID: 3828533.
      View in: PubMed
    63. Chehab F, Honig GR, Kan YW. Spontaneous mutation in beta-thalassaemia producing the same nucleotide substitution as that in a common hereditary form. Lancet. 1986 Jan 04; 1(8471):3-5. PMID: 2867271.
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    64. Khouri FP, Chehab F, Deeb SS, Habbal ZM, Muallem HE. Genetic studies in a selected group of Lebanese beta-thalassemic patients. J Med Liban. 1986; 36(2):69-71. PMID: 3783632.
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    65. Chehab F, Khouri FP, Deeb SS. Globin synthetic ratios in homozygous beta-thalassemia patients from Lebanon. Hemoglobin. 1984; 8(2):151-62. PMID: 6206028.
      View in: PubMed
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